JP5584136B2 - 担体 - Google Patents
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- JP5584136B2 JP5584136B2 JP2010538906A JP2010538906A JP5584136B2 JP 5584136 B2 JP5584136 B2 JP 5584136B2 JP 2010538906 A JP2010538906 A JP 2010538906A JP 2010538906 A JP2010538906 A JP 2010538906A JP 5584136 B2 JP5584136 B2 JP 5584136B2
- Authority
- JP
- Japan
- Prior art keywords
- annexin
- vitamin
- pharmaceutical composition
- derivative
- tocopherol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 108050008874 Annexin Proteins 0.000 claims description 44
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- 150000003712 vitamin E derivatives Chemical class 0.000 claims description 32
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- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000005846 sugar alcohols Polymers 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 102000003137 synaptotagmin Human genes 0.000 description 1
- 108060008004 synaptotagmin Proteins 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- 229960005294 triamcinolone Drugs 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019168 vitamin K Nutrition 0.000 description 1
- 239000011712 vitamin K Substances 0.000 description 1
- 150000003721 vitamin K derivatives Chemical class 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229940046010 vitamin k Drugs 0.000 description 1
- 239000002478 γ-tocopherol Substances 0.000 description 1
- QUEDXNHFTDJVIY-DQCZWYHMSA-N γ-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-DQCZWYHMSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Ophthalmology & Optometry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0724772.9 | 2007-12-19 | ||
| GBGB0724772.9A GB0724772D0 (en) | 2007-12-19 | 2007-12-19 | Carrier |
| PCT/GB2008/004233 WO2009077769A2 (en) | 2007-12-19 | 2008-12-19 | Carrier |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011507820A JP2011507820A (ja) | 2011-03-10 |
| JP2011507820A5 JP2011507820A5 (cg-RX-API-DMAC7.html) | 2012-02-02 |
| JP5584136B2 true JP5584136B2 (ja) | 2014-09-03 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010538906A Expired - Fee Related JP5584136B2 (ja) | 2007-12-19 | 2008-12-19 | 担体 |
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| US (1) | US9539203B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2234596B1 (cg-RX-API-DMAC7.html) |
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| CN (1) | CN102083411B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2709259C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2612347T3 (cg-RX-API-DMAC7.html) |
| GB (1) | GB0724772D0 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009077769A2 (cg-RX-API-DMAC7.html) |
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| GB0905348D0 (en) * | 2009-03-27 | 2009-05-13 | Ucl Business Plc | Carrier |
| IL282113B2 (en) * | 2018-11-21 | 2024-11-01 | Knauf Gips Kg | Use of co2 as water demand reducer in gypsum stucco rehydration mortars |
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| US5198432A (en) * | 1988-01-29 | 1993-03-30 | Center For Innovative Technology | Method of preventing chlorohydrocarbon toxicity using sterol derivatives |
| WO1995030420A1 (en) * | 1994-05-06 | 1995-11-16 | Alcon Laboratories, Inc. | Use of vitamin e tocopheryl derivatives in ophthalmic compositions |
| WO2003090682A2 (en) * | 2002-04-25 | 2003-11-06 | The Scripps Research Institute | Treatment and prevention of pulmonary conditions |
| ITRM20030153A1 (it) * | 2003-04-03 | 2004-10-04 | Exall S R L | Formulazione idrosolubile contenente ubichinone per uso oftalmico. |
| US20110014270A1 (en) * | 2006-03-27 | 2011-01-20 | The Regents Of The University Of Colorado | Prevention and treatment of ischemia-reperfusion injury and related conditions |
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2007
- 2007-12-19 GB GBGB0724772.9A patent/GB0724772D0/en not_active Ceased
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2008
- 2008-12-19 EP EP08862245.1A patent/EP2234596B1/en not_active Not-in-force
- 2008-12-19 JP JP2010538906A patent/JP5584136B2/ja not_active Expired - Fee Related
- 2008-12-19 WO PCT/GB2008/004233 patent/WO2009077769A2/en not_active Ceased
- 2008-12-19 CN CN200880121274.9A patent/CN102083411B/zh not_active Expired - Fee Related
- 2008-12-19 CA CA2709259A patent/CA2709259C/en active Active
- 2008-12-19 ES ES08862245.1T patent/ES2612347T3/es active Active
- 2008-12-19 US US12/809,262 patent/US9539203B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011507820A (ja) | 2011-03-10 |
| US9539203B2 (en) | 2017-01-10 |
| US20100278747A1 (en) | 2010-11-04 |
| CN102083411A (zh) | 2011-06-01 |
| CA2709259A1 (en) | 2009-06-25 |
| EP2234596A2 (en) | 2010-10-06 |
| GB0724772D0 (en) | 2008-01-30 |
| EP2234596B1 (en) | 2016-10-19 |
| CA2709259C (en) | 2016-07-26 |
| CN102083411B (zh) | 2014-12-03 |
| WO2009077769A2 (en) | 2009-06-25 |
| WO2009077769A3 (en) | 2010-02-18 |
| ES2612347T3 (es) | 2017-05-16 |
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