JP5576062B2 - Topical skin preparation - Google Patents

Description

  The present invention relates to an external preparation for skin formed by mixing two types of emulsions having different particle diameters, in particular, an external preparation for massage, and a massage method using such an external preparation for skin.

  Applying the skin external preparation for massage using oil-in-water emulsified cosmetics to the skin and massaging the emulsion composition on the skin, changing from an oil-in-water emulsion to a water-in-oil emulsion It has a unique feeling that the elongation becomes very light. This type of oil-in-water emulsion is known as described in Patent Document 1.

  The emulsion having a fine particle size is obtained from the fineness of the particle size to obtain a transparent emulsion (Patent Document 2), improving the emulsion stability (Patent Document 3), and promoting the penetration of active ingredients into the skin. Various studies have been made for the purpose of (Patent Document 4).

JP 2007-153754 A JP-A-8-92059 JP-A-2005-103421 JP 2004-168702 A

  Conventional external preparations that phase-invert from an oil-in-water emulsion to a water-in-oil emulsion on the skin suddenly become lighter after use, and no further massage effect can be expected. An object of the present invention is to provide an external preparation for skin that can provide a massage effect even after phase inversion from an oil-in-water emulsion to a water-in-oil emulsion.

  The skin external preparation of the present invention comprises (A) an oil-in-water emulsion having an average particle diameter of 0.2 μm or more and less than 20 μm, and (B) an average particle diameter of 5 to 1.0% by mass with respect to the total amount of the skin external preparation. And an oil-in-water emulsion of less than 200 nm. The skin external preparation of the present invention is optimally used as a skin external preparation for massage.

  The present invention also provides a massage method using such an external preparation for skin.

  The external preparation for skin of the present invention exhibits a massage effect even after phase inversion from an oil-in-water emulsion to a water-in-oil emulsion, and exhibits a high massage effect.

It is a figure which shows the increase rate of the blood flow rate before and behind performing massage using Example 1 and Comparative Example 1. FIG. It is a figure which shows the feeling of resistance at the time of using Example 1 and the comparative example 1. FIG. It is a figure which shows the dynamic viscoelasticity of Example 1 and Comparative Example 1. It is a figure which shows the shape of the skin external preparation after the dynamic viscoelasticity measurement of Example 1 and Comparative Example 1.

  The skin external preparation of the present invention comprises (A) an oil-in-water emulsion having an average particle diameter of 0.2 μm or more and less than 20 μm, and (B) an average particle diameter of 5 to 1.0% by mass with respect to the total amount of the skin external preparation. And an oil-in-water emulsion of less than 200 nm.

  When the blending amount of the emulsion of (B) exceeds 5.0% by mass, a problem may occur in the emulsification stability of the external preparation for skin. On the other hand, when the amount is less than 1.0% by mass, the massage effect after phase inversion is significantly reduced.

  Each of the emulsions (A) and (B) of the present invention contains an aqueous component, an oily component and a surface active component as essential components.

  As an aqueous component, what can be normally used for a skin external preparation can be mix | blended in the range which does not impair the stability of an emulsion. In addition to purified water, such components include 1,3-butylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, hexylene glycol, glycerin, diglycerin, xylitol, maltitol, maltose, D- Mannit, trehalose, etc. Water-soluble polymers include gum-based polymers such as gum arabic, carrageenan, pectin, agar, quince seed (quince), starch, and alge colloid (brown algae extract), microbial polymers such as dextran and pullulan, collagen, and casein. Animal polymers such as gelatin, starch polymers such as carboxymethyl starch and methylhydroxypropyl starch, alginic acid polymers such as sodium alginate, vinyl polymers such as carboxyvinyl polymer, polyoxyethylene polymers, Examples thereof include polyoxyethylene polyoxypropylene copolymer-based polymers, acrylic polymers such as sodium polyacrylate and polyacrylamide, and inorganic water-soluble polymers such as bentonite, aluminum magnesium silicate, and laponite.

  As an oil component, what can be normally used for a skin external preparation can be mix | blended in the range which does not impair the stability of an emulsion. Such components are not particularly limited as oil components, and may be solid, semi-solid, or liquid, and may be volatile or non-volatile. For example, hydrocarbons such as paraffin, petrolatum, crystal oil, ceresin, ozokerite, montan wax, squalane, squalene; eucalyptus oil, peppermint oil, camellia oil, macadamia nut oil, avocado oil, beef tallow, tallow, horse fat, egg yolk fat, Beeswax, olive oil, carnauba wax, lanolin, jojoba oil, meadow foam oil, palm oil, palm kernel oil; glycerin monostearate, glyceryl distearate, glycerin monooleate, isopropyl palmitate, isopropyl stearate, stearic acid Butyl, isopropyl myristate, neopentyl glycol dicaprate, diethyl phthalate, myristyl lactate, diisopropyl adipate, cetyl myristate, myristyl lactate, diisopropyl adipate Pill, cetyl myristate, cetyl lactate, 1-isostearoyl-3-myristoyl glycerol, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, 2-octyldodecyl myristate, neopentyl di-2-ethylhexanoate Ester oil such as glycol, oleic acid-2-octyldodecyl, glycerol triisostearate, di-paramethoxycinnamic acid-mono-2-ethylhexanoic acid glyceryl; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, Higher fatty acids such as behenic acid, oleic acid, hydroxystearic acid, undecylenic acid; isostearyl alcohol, octyldodecanol, hexyldecanol, cholesterol, phytosterol, lauryl alcohol, myristic Alcohol, cetanol, stearyl alcohol, oleyl alcohol, and higher alcohols such as behenyl alcohol.

  Further, as silicones, those usually used in cosmetics, for example, octamethylpolysiloxane, tetradecamethylpolysiloxane, methylpolysiloxane, highly polymerized methylpolysiloxane, methylphenylpolysiloxane, octamethylcyclotetrasiloxane, Examples thereof include methyl polycyclosiloxanes such as decamethylcyclopentasiloxane, trimethylsiloxysilicic acid, and further modified silicones such as alkyl-modified silicone, polyether / alkyl-modified silicone, alkyl glyceryl ether-modified silicone, and modified organopolysiloxane.

  In addition, examples of the fluorinated oils include perfluoropolyethers and fluorine-modified silicones, which are perfluoro organic compounds that are liquid at room temperature, such as perfluorodecalin, perfluoroadamantane, perfluorobutyltetrahydrofuran, perfluorooctane, Examples thereof include fluorononane, perfluoropentane, perfluorodecane, perfluorododecane, and fluorine-modified silicone.

  In the external preparation for skin of the present invention, these oil components are used alone or in combination of two or more.

  The aqueous component and the oil component are preferably blended at a ratio of 30:70 to 70:30. When the ratio of the aqueous component is less than 30, there may be a problem in the emulsification stability of the oil-in-water emulsion before use. When the proportion of the aqueous component exceeds 70, phase inversion at the time of use becomes too slow, causing problems in actual use, and a good massage effect may not be obtained.

  Examples of the surfactant component include POE-branched alkyl ethers such as polyoxyethylene (hereinafter referred to as POE) -octyldodecyl alcohol and POE-2-decyltetradecyl alcohol; POEs such as POE-oleyl alcohol ether and POE-cetyl alcohol ether -Alkyl ethers; sorbitan esters such as sorbitan monooleate, sorbitan monoisostearate and sorbitan monolaurate; POE- such as POE-sorbitan monooleate, POE-sorbitan monoisostearate, and POE-sorbitan monolaurate Sorbitan ester; glycerol fatty acid ester such as glycerol monooleate, glycerol monostearate, and glycerol monomyristate; POE-glycerol monooleate, PO POE-glycerin fatty acid esters such as E-glycerin monostearate and POE-glycerin monomyristate; POE-cured castor oils such as POE-dihydrocholesterol ester, POE-cured castor oil, and POE-cured castor oil isostearate Fatty acid esters; POE-alkyl aryl ethers such as POE-octylphenyl ether; glycerin alkyl ethers such as monoisostearyl glyceryl ether and monomyristyl glyceryl ether; POE-glycerins such as POE-monostearyl glyceryl ether and POE-monomyristyl glyceryl ether Alkyl ethers; diglyceryl monostearate, decaglyceryl decastate, decaglyceryl decaisostearate, and diglyceryl diisos Various nonionic surfactants such as polyglycerol fatty acid esters such as allate; potassium, sodium, diethanolamine, triethanolamine of higher fatty acids such as myristic acid, stearic acid, palmitic acid, behenic acid, isostearic acid, and oleic acid, Various salts such as amino acids; potassium or sodium salts of ether carboxylic acids; salts of N-acyl amino acids; N-acyl sarconates; anionic surfactants such as higher alkyl sulfonates; alkylamine salts, polyamines, amino alcohols Examples include cationic surfactants such as fatty acid organic silicone resins and alkyl quaternary ammonium salts; amphoteric surfactants such as imidazolium betaine derivatives; naturally occurring surfactants such as lecithin and saponin. These surfactant components may be used alone or in any combination of two or more.

  The external preparation for skin according to the present invention contains an aqueous component, an oily component, a surface active component, which are essential components, a moisturizer, an anti-inflammatory agent, an antibacterial agent, a whitening agent, an anti-aging agent, an antioxidant, and the like. be able to.

  The external preparation for skin of the present invention can be produced by mixing the emulsion according to (A) with the emulsion according to (B) prepared in advance.

  The preparation method of each emulsion is not specifically limited, It can prepare according to a conventional method.

  The emulsion according to (B) is a fine emulsion having an average emulsion particle size of 5 nm or more and less than 200 nm. Examples of the emulsification method for obtaining the fine emulsion include a surface chemical method such as a phase inversion temperature emulsification method, an aggregation method, a liquid crystal emulsification method, and a D phase emulsification method, and a machine such as a high pressure emulsifier, a high shear disperser, and a colloid mill. The method of combining the individual methods or combining a plurality of methods.

  The skin external preparation of this invention can be utilized as a skin external preparation for massage. When used as an external preparation for massage, the oil-in-water emulsion can be used to obtain a good massage effect as usual, and even after phase inversion to a water-in-oil emulsion on the skin. You can get a massage effect.

  The skin external preparation of the present invention can be used as a cleansing skin external preparation that can be expected to have a cleansing effect simultaneously with a massage effect. When used as an external preparation for cleansing skin, it feels the same as before when using an oil-in-water emulsion, but there is no sudden change in elongation even after phase inversion to a water-in-oil emulsion on the skin. , You can get a whole new feeling of use.

  The skin external preparation of this invention can acquire the effect of both cleansing and a massage by one-time use.

  The present invention provides a massage method using the above-mentioned external preparation for skin. By performing massage using the external preparation for skin of the present invention, a new feeling of use that is completely different from the conventional one can be obtained. In other words, in the case of an oil-in-water emulsion, in addition to being a feeling of use that can realize a massage effect with a resistance feeling as before, when the phase is changed to a water-in-oil emulsion, the elongation suddenly becomes lighter. Therefore, it is possible to maintain a proper elongation and obtain a good massage effect. The specific method of massage is not particularly limited.

  Table 1 shows formulation examples of the external preparation for skin of the present invention. The skin external preparation according to Example 1 first prepares a fine emulsion of component C and component D using a liquid crystal emulsification method. Example 1 was prepared by further adding a fine emulsion to what was emulsified using the A component and B component homomixers. For comparison, a skin external preparation not containing a fine emulsion was prepared by emulsifying an aqueous component obtained by mixing the A component and the D component and an oily component obtained by mixing the B component and the C component with a homomixer. .

[Measurement of emulsion average particle size]
The average particle size of the fine emulsion of Example 1 was measured using “Zeta potential / particle size measurement system ELSZ” manufactured by Otsuka Electronics Co., Ltd. As a result, the average particle size was 55 nm. Moreover, as a result of measuring the average particle diameter of the emulsion emulsified using the A component and the C component in Example 1 using “SALD-300V Shimadzu Laser Diffraction Particle Size Distribution Measuring Device” manufactured by Shimadzu Corporation, the average particle size was obtained. Was 1.1 μm.

[Measurement of blood flow]
In order to quantitatively measure the massage effect, the blood flow before and after the massage was measured using Example 1 and Comparative Example 1.
Equipment used: LASER FLOWMETER Non-Contact ALF21N (ADVANCE Co., LTD)
Measurement site: 3-point test method on the center, outer and lower sides of the cheek:
The subject removes the makeup in advance, cleans with the facial cleanser, and stays still for 5 minutes. The blood flow before massage was measured after 5 minutes. Thereafter, 2 g of Example 1 or Comparative Example 1 was applied to the cheek and massaged for 2 minutes, and then the external preparation for skin was wiped off using tissue paper, and the blood flow after massage was measured.

  The results were calculated as relative values when the blood flow volume before massage was 1, and are shown in Table 2 and FIG. As a result, Example 1 in which the fine emulsion was blended was shown to have a higher blood flow improvement effect than Comparative Example 1 in which the fine emulsion was not blended.

[Measurement of resistance]
The resistance feeling of Example 1 and Comparative Example 1 was measured as an index quantitatively indicating the elongation of the external preparation for skin.
Equipment used: KES-SE friction tester (manufactured by Kato Tech)
Measurement condition:
* Sample amount: 70mg
* Load: 25mg
* Travel speed: 1mm / sec.
* Probe type: Artificial leather x Artificial leather * Repeated measurement without wiping 20 times: 2 times

  As a result, an average friction coefficient for each stretched number was calculated and shown in FIG. As shown in FIG. 2, it was shown that the skin external preparation of the present invention containing a fine emulsion has a high average friction coefficient and a high massage effect as compared with the case where no fine emulsion is contained.

[Measurement of dynamic viscoelasticity]
In order to quantitatively evaluate the feeling of use when massaging on the skin, dynamic viscoelasticity was measured using Example 1 and Comparative Example 1.
Equipment used: AR2000 (TA Instruments)
Measurement condition:
* Jig used = 2mm cone plate * Measurement mode = Applied strain sweep step mode * Applied strain = 0.01% to 1000%
* Measurement frequency = 1Hz
* Measurement temperature = 33 ℃
* Display mode during measurement = logarithm * Decade per point (display interval) = 10
* Sample amount = 5cm ³

  The results are shown in FIG. 3 as Tan δ with respect to the strain amount. Using Example 1 and Comparative Example 1, the difference caused by the presence or absence of the fine emulsion blending shows a clear difference in Tan δ when the strain amount [%] increases. Tanδ indicates how much energy the material absorbs (transforms into heat) when the material is deformed, and is an index indicating the heat conversion efficiency. As shown in the figure, as the amount of strain increases, the skin external preparation containing the fine emulsion of Example 1 becomes relatively high, and it is very effective for a massage that gives warmth and increases blood flow. It was done.

  The state of the external preparation for skin after the dynamic viscoelasticity measurement is shown in FIG. After straining up to 1000%, when the cone plate of the viscoelasticity measuring device is pulled up, Example 1 in which the fine emulsion is blended forms an angled state, and even inside the dynamic change (strain) The film formability was maintained by friction. On the other hand, in Comparative Example 1 in which no fine emulsion was blended, the formation of corners was not recognized, and the skin external preparation spread over the entire surface. This means that by using a fine emulsion in addition to a normal emulsion in addition to a normal emulsion, the bulk film can be maintained during the latter half of the massage in actual use. To do.

[Real use test]
Using Example 1 and Comparative Example 1, eight women in their 20s to 40s were used to evaluate the feeling of use. Each evaluator used Example 1 and Comparative Example 1, respectively, performed comparative evaluation on the following evaluation items, and summarized the evaluation results in Table 3 by consultation.

    The skin external preparation of the present invention is useful as a skin external preparation for massage that can provide a high blood flow promoting effect. Moreover, the massage method using the skin external preparation of this invention is useful as a massage method with which the high blood-flow promotion effect is acquired.

Claims (2)

(A) Oil-in-water emulsion having an average particle size of 0.2 μm or more and less than 20 μm, and (B) Oil-in-water emulsion having an average particle size of 5 nm or more and less than 200 nm of 1.0 to 5.0% by mass based on the total amount of the external preparation for skin. A skin external preparation of the type that phase-shifts from an oil-in-water emulsion to a water-in-oil emulsion on the skin, comprising an aqueous component and an oily component in a ratio of 30:70 to 70:30. The skin external preparation according to claim 1, which is a skin external preparation for massage.

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