JP5566677B2 - An androgen action inhibitor, prostate enlargement inhibitor, and androgen-dependent hair loss inhibitor containing whole plants other than banana fruit as active ingredients - Google Patents

Description

  The present invention relates to a composition for the purpose of suppressing androgen action, prostate hypertrophy, and androgen-dependent hair loss, and food and drink, animal feed, cosmetics or pharmaceuticals containing the composition.

  It is known that the prostate enlarges in an androgen-dependent manner. Since the age of 60 years, the prostate has enlarged, and more than half of men complain of problems such as nocturia and decreased urination, which is a serious problem for older men. Currently, saw palmetto, pumpkin seed extract, and alpha1-blocker and antiandrogen are used as foods for preventing and improving prostate hypertrophy. Is desired.

  Although it has already been reported that the banana peel has an antiandrogenic action (see Patent Document 1), it is not known about the medicinal effect in each part other than the banana peel, and therefore each part other than the banana peel is extracted. There is no report that the substance has a prostatic hypertrophy inhibitory effect and is effective in the prevention and treatment of prostatic hypertrophy.

Patent Publication 2008-174551

  The banana related to the present invention is the scientific name Musa spp. A banana is a plant consisting of leaf blades, petioles, leaf treetops, pseudostems and suckers corresponding to leaves and stems. Moreover, the pseudostem and sucker stem corresponding to the stem are referred to as a banana stem. In addition, the fruit axis of the root of the fruit follows this.

  The present invention provides a composition having an androgen action-inhibiting action, a prostatic hypertrophy-inhibiting action and an androgen-dependent hair loss inhibiting action, and thus providing a food, drink, animal feed, cosmetic or pharmaceutical product containing the composition. It is in.

As a result of intensive studies in order to solve the above-mentioned problems, it has been found that whole plant extracts excluding banana fruits such as banana stems and banana leaves have a remarkable prostatic hypertrophy inhibitory effect. That is, the present invention has the following configuration.
(1) A male hormone action-suppressing composition comprising whole plant excluding banana fruit and an extract thereof.
(2) A composition for suppressing prostatic hypertrophy, comprising whole plant excluding banana fruit and its extract.
(3) An androgen-dependent hair loss inhibitory composition comprising whole plant excluding banana fruit and an extract thereof.
(4) Food / beverage products, animal feed, cosmetics or pharmaceuticals containing the composition according to (1), (2) or (3) above.

  According to the present invention, an androgen action-suppressing composition, a prostatic hypertrophy-suppressing composition, an androgen-dependent hair loss suppressing composition, and a food and drink containing the composition, characterized by containing whole plants excluding banana fruits Animal feed, cosmetics or pharmaceuticals can be provided.

  The whole plant excluding banana fruit used in this study refers to the ground parts such as banana leaves and banana stems. Preferably, it is obtained by extraction from one or both of leaves and stems.

  The whole plant except the banana fruit according to the present invention may be used as it is, or may be used as a dried product obtained by drying, or after pulverization after drying. Moreover, what extracted these with water or organic solvents, such as alcohol, can also be used.

  In order to produce the prostatic hypertrophy inhibitor and the androgen action inhibitor according to the present invention, the whole plant excluding the banana fruit produced by the above method or an extract thereof is used and combined with a known non-toxic carrier according to a conventional method. Can be formulated. The prostatic hypertrophy inhibitor according to the present invention can be administered in various dosage forms. For example, oral administration agents include solid agents such as tablets, granules, powders, capsules, soft capsules, solutions, suspensions, and the like. Examples include suspensions, liquids such as emulsions, and parenteral preparations include injections, suppositories, sprays, transdermal absorption agents, and the like. can do. Examples of the non-toxic carrier include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, albumin, water, physiological Examples include saline. If necessary, conventional additives such as stabilizers, lubricants, wetting agents, emulsifiers, binders and the like can be appropriately added. In the prostatic hypertrophy inhibitor according to the present invention, the dose of whole plant excluding banana fruit or its extract is appropriately selected / determined according to the patient's age, weight, symptoms, disease severity, administration schedule, formulation form, etc. However, for example, it is about 0.01-10 g / kg body weight per day, and may be divided into several times a day.

  In addition, the whole plant except the banana fruit related to the present invention is rarely used for food, but for the purpose of suppressing androgenic action, prostate hypertrophy and inhibiting androgenic hair loss It can also be taken as food. The functional food characterized by containing the whole plant excluding the banana fruit according to the present invention can be positioned as a food for specified health use, a nutritional functional food, or a health food. As the functional food, in addition to using the whole plant or extract excluding the banana fruit produced by the above method as it is, for example, after adding a suitable auxiliary agent, using a conventional means, a form suitable for food For example, those formed into granules, granules, tablets, capsules, pastes, and the like can be used. This functional food may be used for food as it is, or added to various foods (eg, ham, sausage, kamaboko, chikuwa, bread, butter, milk powder, confectionery, etc.), water, alcoholic beverages, fruit juice It may be used by adding to drinks such as milk and soft drinks. The amount of intake of the present invention in the form of such food is appropriately selected and determined according to age, weight, symptoms, intake schedule, formulation form, etc., for example, about 0.01-10 g / kg body weight per day. The

  Examples are given below to describe the present invention in more detail, but the present invention is not limited by these.

Example 1 Prostatic Hypertrophy Inhibition Action of Banana Leaf and Banana Stem The following experiment was conducted to examine the effect of inhibiting banana leaf methanol extract and banana stem methanol extract on prostatic hypertrophy. Banana leaves and stalks were each immersed in methanol for one day and dried under reduced pressure to obtain extracts of banana leaves and banana stems. The testis of 7-week-old male ddY mice (n = 5) was excised, and the banana leaf extract (100 mg / kg) and banana stem extract (100 mg / kg) were dissolved in 0.2 ml of distilled water from the next day. Was administered orally. At the same time, testosterone propionate (2.0 mg) dissolved in 0.1 ml of corn oil was injected intraperitoneally as a male hormone. This was performed once a day for 10 days and dissected on the day after the final administration day, and the short diameter and long diameter of the prostate were measured. The results are shown in Table 1. At the same time, seminal vesicle glands were removed and weighed. The results are shown in Table 2. Here, group A (control) was administered testosterone propionate only to the testis removed, group B was administered testosterone propionate and banana leaf extract to the testis removed, group C was testosterone propionate to the testis removed And banana stem extract.
Each value represents an average value ± standard error. The significance test was performed by Student's t-test. * Indicates p <0.05 with respect to the control, and *** indicates p <0.005 with respect to the control.

  From the results in Table 1, it was shown that the banana leaf and banana stem extracts markedly suppressed the enlargement of the prostate due to male hormones, respectively, relative to the control. In addition, the results in Table 2 showed that the banana leaf and banana stem extract suppressed the increase in seminal vesicle gland weight with respect to the control. The seminal vesicle gland is known to increase in size in a male hormone-dependent manner, similar to the prostate gland, and these results indicate that banana leaf extract and banana stem extract have an androgen-inhibiting action. Indicated. From these experimental results, it can be presumed that it clearly has an inhibitory effect on androgen-dependent hair loss.

Example 2 Inhibition of Prostatic Hypertrophy of Banana Leaves and Banana Stalks The following experiment was conducted to examine whether the methanol extract of banana leaves and the methanol extract of banana stems had an androgenic action, ie, an androgenic action. It was. The banana sample extract was prepared in the same manner as in Example 1. The ratio of the number of cells proliferated by adding androgen to human prostate cancer-derived LNCaP cells known to proliferate in an androgen-dependent manner and culturing for a certain period of time was examined. When cultured for 7 days in the absence of androgen, the number of cells increases to about 1.5 times, but increases to about 3 times when 2 mg / ml of testosterone (T) is added as an androgen. The number of viable cells was calculated by measuring the formazan dye produced in the cells by MTT treatment with an absorptiometer (550 nm). The antiandrogenic activity of the sample was evaluated by the change in cell growth rate when the sample was added simultaneously with androgen. As shown in FIG. 1, when a banana sample (25 μg / ml) was added as a sample, cell growth by androgen was remarkably suppressed depending on the concentration. It was shown that there is. Since it is known that male hormone-dependent hair loss can be suppressed by male hormone-inhibiting action, that is, antiandrogenic action, banana leaf / stalk extract with antiandrogenic action can also be used as an inhibitor of male hormone-dependent hair loss. It is clear that there is.

  According to the present invention, an androgen action-inhibiting composition, a prostatic hypertrophy-inhibiting composition and an androgen-dependent hair loss-inhibiting composition characterized by containing a whole plant extract excluding banana fruits, and the composition It has become possible to provide food, drink, animal feed, cosmetics or pharmaceuticals.

Claims (3)

A medicinal product for suppressing androgenic action, comprising whole plant excluding banana fruit and its extract. A medicinal product for suppressing prostate hypertrophy, comprising whole plant excluding banana fruit and an extract thereof. A male hormone-dependent hair loss-suppressing pharmaceutical comprising a whole plant excluding banana fruit and an extract thereof.