JP2007230983A - Prostatic hypertrophy inhibitor - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide foods and drinks, medicines and animal fodders, having prostatic hypertrophy inhibitory action. <P>SOLUTION: The foods and drinks, medicines and animal fodders, comprising components contained in Houttuynia cordata Thunb and for inhibiting prostatic hypertrophy are provided. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

The present invention relates to pharmaceuticals, foods and drinks or animal feeds for the purpose of suppressing prostate hypertrophy.

It is known that the prostate enlarges in an androgen-dependent manner. Since the age of 40 years old, the prostate began to enlarge, and more than half of the elderly men complained of problems such as nocturia and decreased urination, which is a serious problem for men. Currently, α1-blockers, antiandrogens, etc. are used as pharmaceuticals such as saw palmetto extract and pumpkin seed extract as foods for preventing and improving prostate hypertrophy. Development is desired.

Dokudami is a plant with a unique odor, and what is washed and sun-dried is called ten medicines. It is said to be effective for high blood pressure, prevention of arteriosclerosis, acute nephritis, and hot eczema, and is sold as tea. However, there is no report that Dokudami is effective in preventing and treating prostate enlargement.

It is to provide pharmaceuticals, foods and drinks or animal feeds for the purpose of suppressing prostate hypertrophy.

As a result of intensive studies in order to solve the above-mentioned problems, it was found that Dokudami has a remarkable effect of suppressing prostate hypertrophy. That is, the present invention provides pharmaceuticals, foods and drinks, or animal feeds for the purpose of suppressing prostatic hypertrophy with dokudami as an active ingredient.

ADVANTAGE OF THE INVENTION By this invention, the pharmaceutical, food-drinks, or animal feed aiming at the suppression of the prostatic hypertrophy which uses dokudami as an active ingredient can be provided.

The dokudami related to the present invention refers to Houttynia cordadata chumb.

The whole body or a leaf part may be used as it is for the damselfly related to the present invention, and a dried product obtained by drying these, or a powder obtained by pulverizing after drying can also be used. Moreover, what extracted these with water or organic solvents, such as alcohol, can also be used.

In order to produce the prostatic hypertrophy inhibitor according to the present invention, the dokudami produced by the above method or an extract thereof may be used in combination with a known non-toxic carrier according to a conventional method. The prostatic hypertrophy inhibitor according to the present invention can be administered in various dosage forms. For example, oral administration agents include solid agents such as tablets, granules, powders, capsules, and soft capsules, solutions, and suspensions. Examples of the parenteral preparation include injections, suppositories, sprays, and percutaneous absorption agents. These preparations are prepared by conventional means in the preparation. Can be adjusted. Examples of the non-toxic carrier include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, albumin, water, physiological Examples include saline. If necessary, conventional additives such as stabilizers, lubricants, wetting agents, emulsifiers, binders and the like can be appropriately added. In the prostatic hypertrophy inhibitor according to the present invention, the dose of dokudami is appropriately selected and determined according to the patient's age, weight, symptom, degree of disease, administration schedule, formulation form, etc. The dose is about 0.01-1 g / kg body weight, and may be administered in several divided doses a day.

In addition, the dokudami related to the present invention is highly safe because it has abundant eating experience, and can be taken as a food or drink for the purpose of suppressing prostate hypertrophy. The food / beverage products characterized by containing the dokudami concerning this invention can be positioned as a food for specific health, a nutritional functional food, or a health food. As food and drink, in addition to using the dokudami or extract produced by the above method as it is, for example, after adding a suitable auxiliary agent, using conventional means, a form suitable for food, for example, granular, granular , Tablets, capsules, pastes and the like can be used. This food and drink may be used for food as it is, and used by adding it to various foods and drinks (for example, ham, sausage, kamaboko, chikuwa, bread, butter, milk powder, confectionery, etc.), water, alcoholic beverages, fruit juice It may be used by adding to drinks such as milk and soft drinks. The amount of intake of the present invention in the form of such food and drink is appropriately selected and determined according to age, weight, symptoms, intake schedule, formulation form, etc., for example, about 0.001-1 g / kg body weight per day Is done.

Examples are given below to describe the present invention in more detail, but the present invention is not limited by these.

Example 1 Prostatic hypertrophy inhibitory effect of dokudami The following experiment was conducted to examine the prostatic hypertrophy inhibitory effect of dokudami. A rough cut leaf (100 g) of Dokudami was immersed in 10 times the amount of methanol for one day, the extract was dried under reduced pressure, and the resulting extract was used as a test sample. The testis of 7-week old male ddY mice was removed. Testis-extracted mice were divided into 3 groups (n = 8), corn oil B was administered to group A, and testosterone (52 mg / kg) dissolved in corn oil was intraperitoneally administered to group C for 2 weeks. In addition, water was administered to the A and B groups, and an aqueous solution (100 mg / kg) of a docamimethanol extract was orally administered to the C group for 2 weeks. Two weeks later, the animals were dissected and the sizes of the prostate and seminal vesicles were measured. Since the prostate of the testis-extracted mouse was very small and accurate weight measurement was difficult, the length of the major axis and the minor axis were measured using a precision caliper under a stereomicroscope without removing the prostate. The seminal vesicles were removed and weighed. The results are shown in Table 1. The measured value indicates an average value ± standard error. * Is attached to the case where p <0.05 with respect to Group A (Student's t-test).

From this result, it was shown that the extract of Dokudami remarkably suppresses the enlargement of the prostate due to testosterone. Therefore, Dokudami is useful for preventing and improving prostate enlargement.

ADVANTAGE OF THE INVENTION By this invention, the pharmaceutical or food-drinks aiming at the suppression of the prostatic hypertrophy which uses dokudami as an active ingredient can be provided.

Claims (8)

  A prostatic hypertrophy inhibitor, comprising a component contained in Houttuynia corda Thunb.   The prostatic hypertrophy inhibitor according to claim 1, wherein the component is contained as an extract of Houttuynia cordata chumb.   The prostatic hypertrophy inhibitor according to claim 2, wherein the extract is an extract of water or an organic solvent.   A health food having an action to suppress prostate hypertrophy characterized by containing a component contained in Houttuynia corda Thunb.   The health food according to claim 4, wherein the ingredient is contained as an extract of Houttuynia corda chumb.   The health food according to claim 4 or 5, which is in the form of food or beverage.   An animal feed having an action to suppress prostate hypertrophy characterized by containing an ingredient contained in Houttuynia cordata chumb.   The animal feed according to claim 7, wherein the ingredient is contained as an extract of Houttunia cordata chumb.