JP5490695B2 - インフルエンザウイルスｈ５亜型からのヘマグルチニンに特異的なモノクローナル抗体およびそれらの使用 - Google Patents
インフルエンザウイルスｈ５亜型からのヘマグルチニンに特異的なモノクローナル抗体およびそれらの使用 Download PDFInfo
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- JP5490695B2 JP5490695B2 JP2010524822A JP2010524822A JP5490695B2 JP 5490695 B2 JP5490695 B2 JP 5490695B2 JP 2010524822 A JP2010524822 A JP 2010524822A JP 2010524822 A JP2010524822 A JP 2010524822A JP 5490695 B2 JP5490695 B2 JP 5490695B2
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Classifications
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- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
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- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
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- Hematology (AREA)
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| Application Number | Priority Date | Filing Date | Title |
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| US97208707P | 2007-09-13 | 2007-09-13 | |
| US60/972,087 | 2007-09-13 | ||
| PCT/SG2008/000313 WO2009035412A1 (en) | 2007-09-13 | 2008-08-26 | Monoclonal antibodies specific to hemagglutinin from influenza virus h5-subtype and uses thereof |
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| JP2010539161A JP2010539161A (ja) | 2010-12-16 |
| JP2010539161A5 JP2010539161A5 (OSRAM) | 2011-10-20 |
| JP5490695B2 true JP5490695B2 (ja) | 2014-05-14 |
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| EP (1) | EP2207804B1 (OSRAM) |
| JP (1) | JP5490695B2 (OSRAM) |
| AU (1) | AU2008297586B2 (OSRAM) |
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| CN101687921A (zh) * | 2007-05-11 | 2010-03-31 | 淡马锡生命科学研究院有限公司 | 可用于h5禽流感诊断和监视的h5亚型特异性结合蛋白 |
| EP2947094B1 (en) | 2007-09-13 | 2018-11-14 | Temasek Life Sciences Laboratory Limited | Monoclonal antibodies specific to hemagglutinin and neuraminidase from influenza virus h5-subtype or n1-subtype and uses thereof |
| US9555093B2 (en) * | 2010-04-30 | 2017-01-31 | Temasek Life Sciences Laboratory Limited | Universal vaccine against H5N1 lineages |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| TWI702229B (zh) | 2014-12-19 | 2020-08-21 | 美商再生元醫藥公司 | 流行性感冒病毒血球凝集素之人類抗體 |
| EP3374390A1 (en) | 2015-11-13 | 2018-09-19 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| CA3015347A1 (en) | 2016-02-24 | 2017-08-31 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| US10766929B2 (en) | 2017-03-15 | 2020-09-08 | University Of Washington | De novo designed hemagglutinin binding proteins |
| CN107831306B (zh) * | 2017-10-10 | 2020-04-24 | 武汉科前生物股份有限公司 | 一种h7亚型禽流感病毒双抗体夹心elisa试剂盒及其检测方法 |
| JP7372925B2 (ja) | 2018-01-26 | 2023-11-01 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | インフルエンザヘマグルチニンに対するヒト抗体 |
| EP3946613A1 (en) | 2019-03-25 | 2022-02-09 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| CN113355344B (zh) * | 2021-08-10 | 2021-11-02 | 北京溯本源和生物科技有限公司 | 一种流感病毒ns1蛋白的表达质粒、重组蛋白和特异性单克隆抗体及应用 |
| CN117683126B (zh) * | 2023-11-08 | 2025-11-21 | 华南农业大学 | 纳米抗体蛋白、用途、表达载体、菌株和药物以及试剂盒 |
| CN120329427B (zh) * | 2025-06-19 | 2025-08-29 | 中国人民解放军军事科学院军事医学研究院 | 一种针对禽流感病毒h5n1血凝素单克隆抗体及其应用 |
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| CN101379397A (zh) * | 2006-01-26 | 2009-03-04 | Hx诊断公司 | H5亚型禽流感病毒血凝素蛋白的单克隆抗体或其结合活性片段及其用途 |
| MY170607A (en) * | 2006-09-07 | 2019-08-20 | Crucell Holland Bv | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| CN101687921A (zh) * | 2007-05-11 | 2010-03-31 | 淡马锡生命科学研究院有限公司 | 可用于h5禽流感诊断和监视的h5亚型特异性结合蛋白 |
| WO2008156763A2 (en) | 2007-06-15 | 2008-12-24 | The Board Of Trustees Of The Leland Stanford Junior University | Human neutralizing monoclonal antibodies to h5n1 influenza a virus |
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| EP2207804B1 (en) | 2015-07-22 |
| JP2010539161A (ja) | 2010-12-16 |
| AU2008297586A1 (en) | 2009-03-19 |
| WO2009035412A8 (en) | 2009-05-22 |
| AU2008297586B2 (en) | 2013-06-20 |
| EP2207804A4 (en) | 2012-04-18 |
| US8444986B2 (en) | 2013-05-21 |
| WO2009035412A1 (en) | 2009-03-19 |
| US20130251715A1 (en) | 2013-09-26 |
| US20100297126A1 (en) | 2010-11-25 |
| EP2207804A1 (en) | 2010-07-21 |
| US9115188B2 (en) | 2015-08-25 |
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