JP5490350B2 - Endurance improver - Google Patents
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- JP5490350B2 JP5490350B2 JP2006184447A JP2006184447A JP5490350B2 JP 5490350 B2 JP5490350 B2 JP 5490350B2 JP 2006184447 A JP2006184447 A JP 2006184447A JP 2006184447 A JP2006184447 A JP 2006184447A JP 5490350 B2 JP5490350 B2 JP 5490350B2
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Description
本発明は、広義の運動に対して、持久力向上作用及び抗疲労作用を発揮する持久力向上剤及び抗疲労剤、並びに脂質燃焼促進効果を発揮する脂質燃焼促進剤に関する。 The present invention relates to an endurance improving agent and an anti-fatigue agent that exhibit endurance enhancing action and anti-fatigue action, and a lipid combustion promoting agent that exhibits lipid burning promoting effect with respect to exercise in a broad sense.
持久力はスポーツ競技において必要とされるだけでなく、我々の日常生活においては歩く、走る等の単純な動作や、筋肉労作を繰り返し行う労働においても必要不可欠なものである。持久力の向上には運動トレーニングが有効であることは広く認識されているが、時間の確保やモチベーションの維持の困難さ、高齢者においては怪我の恐れがあるため、トレーニングによる持久力の維持・向上は決して容易なことではない。また、競技スポーツにおいては、持久力は極めて重要であり、それが競技の勝敗を決めるといっても過言ではない。 Endurance is not only necessary in sports competitions, but in our daily life, it is indispensable for simple movements such as walking and running, and for labor involving repeated muscle work. Although it is widely recognized that exercise training is effective in improving endurance, it is difficult to maintain time and maintain motivation, and injuries may occur in elderly people. Improvement is not easy. In competitive sports, endurance is extremely important, and it is no exaggeration to say that it determines the outcome of the competition.
そこで、食品成分を日常的に摂取することにより持久力を向上させる試みがなされている。ヒトは糖質、脂質、アミノ酸をエネルギー源として利用しているが、それらはグリコーゲン、脂肪、タンパク質として生体に貯蔵されている。グリコーゲンは筋肉及び肝臓に一定量貯蔵されているが、長時間の持久運動には十分でなく、またグリコーゲンが枯渇すると運動は継続できなくなる。すなわち持久力を向上させ、疲労を抑制するためには、グリコーゲンの消費を抑制し、効率的に糖質エネルギーを補給・利用することが重要であると考えられる(非特許文献1、2)。 Thus, attempts have been made to improve endurance by daily intake of food ingredients. Humans use carbohydrates, lipids, and amino acids as energy sources, but they are stored in the living body as glycogen, fat, and protein. A certain amount of glycogen is stored in muscle and liver, but it is not sufficient for long-term endurance exercise, and when glycogen is depleted, exercise cannot be continued. That is, in order to improve endurance and suppress fatigue, it is considered important to suppress glycogen consumption and efficiently replenish and utilize carbohydrate energy (Non-patent Documents 1 and 2).
これまでに、持久力向上作用を有する成分として、例えば茶カテキン(特許文献1)、サンザシ抽出物(特許文献2)やコエンザイムQ10及び、(−)−ヒドロキシクエン酸及びアミノ酸(特許文献3)、カプサイシノイド様物質(特許文献4)等が報告されている。しかしながら、これらの成分を飲食品に配合する場合、飲食品本来の持つ外観、味、歯触り、滑らかさなどの食感の点から、食品中に十分な量で含有させることが困難であり、その結果、実質的に効果が発現できない場合も多いと考えられる。 So far, as a component having endurance-improving action, for example, tea catechin (Patent Document 1), hawthorn extract (Patent Document 2), coenzyme Q10, and (−)-hydroxycitric acid and amino acid (Patent Document 3), Capsaicinoid-like substances (Patent Document 4) have been reported. However, when blending these ingredients in food and drink, it is difficult to contain in a sufficient amount in the food from the viewpoint of food texture such as appearance and taste inherent to food and drink, taste, texture, As a result, it is considered that there are many cases where the effect cannot be substantially exhibited.
一方、ヒドロキシプロピル化澱粉は、食感改善などの目的で広く用いられており、加工特性に優れ、安全性も極めて高い食品素材である。本発明者らはこれまでにヒドロキシプロピル化澱粉の生理作用に関する研究を重ね、抗肥満効果(特許文献5)や便秘改善効果(特許文献6)等を見出しているが、上記の澱粉が持久力向上作用や抗疲労作用、脂質燃焼促進作用を有することはこれまでに知られていない。
本発明は、優れた持久力向上作用、抗疲労作用等を有し、安全性が高く且つ適用範囲が広い素材を用いた医薬品、医薬部外品及び食品を提供することに関する。 The present invention relates to providing pharmaceuticals, quasi-drugs, and foods using materials that have excellent endurance-improving action, anti-fatigue action, etc., high safety, and wide application range.
本発明者らは、食品等に利用されているヒドロキシプロピル化澱粉が、持久力向上剤及び抗疲労剤として有用であること、また、生体のエネルギー代謝を活性化し、脂質燃焼促進作用を有することを見出した。 The present inventors show that hydroxypropylated starch used in foods and the like is useful as an endurance improver and an anti-fatigue agent, and also activates energy metabolism in the living body and has a lipid burning promoting action. I found.
すなわち、本発明は、下記1)〜6)の発明に係るものである。
1)ヒドロキシプロピル化澱粉を有効成分とする持久力向上剤。
2)ヒドロキシプロピル化澱粉を有効成分とする抗疲労剤。
3)ヒドロキシプロピル化澱粉を有効成分とする脂質燃焼促進剤。
4)ヒドロキシプロピル化澱粉を含有し、持久力向上作用を有することを特徴とし、持久力向上のために用いられる旨の表示を付した食品。
5)ヒドロキシプロピル化澱粉を含有し、抗疲労作用を有することを特徴とし、抗疲労のために用いられる旨の表示を付した食品。
6)ヒドロキシプロピル化澱粉を含有し、脂質燃焼促進作用を有することを特徴とし、脂質燃焼促進のために用いられる旨の表示を付した食品。
That is, the present invention relates to the following items 1) to 6).
1) Endurance improver comprising hydroxypropylated starch as an active ingredient.
2) An anti-fatigue agent comprising hydroxypropylated starch as an active ingredient.
3) A lipid burning accelerator containing hydroxypropylated starch as an active ingredient.
4) A food containing a hydroxypropylated starch, characterized by having an endurance-improving action, and labeled as being used to improve endurance.
5) A food containing a hydroxypropylated starch, having an anti-fatigue action, and labeled as being used for anti-fatigue.
6) A food containing a hydroxypropylated starch, having a lipid burning promoting action, and labeled as being used for promoting lipid burning.
本発明の持久力向上剤及び抗疲労剤は、持久力を必要とする運動や、筋肉労作を繰り返し行う必要のある労働等を始めとする広義の運動に対する持久力の向上、疲労の抑制又は回復を発揮する食品、医薬品等として、また、脂質代謝促進作用を発揮する食品、医薬品等として有用である。特に有効成分であるヒドロキシプロピル化澱粉は食品への適用範囲が広く、食品に配合した場合、それらが本来持つ食感を損なうことが少なく、また耐凍結性に優れ、解凍しても変質しにくいことから、各種食品として使用する場合にその有用性が高い。 The endurance improver and anti-fatigue agent of the present invention improve endurance for exercise in a broad sense, including exercise that requires endurance, labor that requires repeated muscular work, and suppression or recovery of fatigue. It is useful as a food, a pharmaceutical, etc. that exerts a function of promoting lipid metabolism and as a food, a pharmaceutical, etc. that exhibits an action of promoting lipid metabolism. In particular, hydroxypropylated starch, which is an active ingredient, has a wide range of application to foods, and when blended in foods, it hardly damages the original texture of the foods, has excellent freezing resistance, and is not easily altered by thawing. Therefore, it is highly useful when used as various foods.
本発明の持久力向上剤における「持久力向上」とは、持久力を必要とする運動や、筋肉労作を繰り返し行う必要のある労働等を始めとする広義の運動に対して、持久力を向上することを意味し、抗疲労剤における「抗疲労」とは、当該運動によって生じる疲労を抑制又は回復することを意味する。
また、脂質燃焼促進剤における「脂質燃焼促進」とは、食事由来あるいは体内に蓄積された脂肪由来の脂質、特に脂肪酸の燃焼を促進することを意味する。
“Endurance improvement” in the endurance improver of the present invention means improvement of endurance for exercise in a broad sense, including exercise that requires endurance and labor that requires repeated muscle work. "Anti-fatigue" in an anti-fatigue agent means to suppress or recover fatigue caused by the exercise.
In addition, the “facilitation of lipid burning” in the lipid burning promoter means promoting the burning of fat-derived lipids, particularly fatty acids derived from meals or accumulated in the body.
本発明におけるヒドロキシプロピル化澱粉とは、澱粉を構成する糖残基中の水酸基の少なくとも一部がヒドロキシプロピル化された澱粉を意味する。
ヒドロキシプロピル化の程度としては、置換度(澱粉中の無水グルコース1残基当たりのヒドロキシプロピル基の数)が0.001〜1であるのが好ましく、より好ましくは0.05〜0.5であり、更に0.1〜0.3であるのが好ましい。
The hydroxypropylated starch in the present invention means a starch in which at least a part of hydroxyl groups in the sugar residue constituting the starch is hydroxypropylated.
As the degree of hydroxypropylation, the degree of substitution (number of hydroxypropyl groups per anhydroglucose residue in starch) is preferably 0.001 to 1, more preferably 0.05 to 0.5. Yes, and preferably 0.1 to 0.3.
本発明のヒドロキシプロピル化澱粉は、澱粉又は加工澱粉を通常の方法によりヒドロキシプロピル化することにより得ることができる。具体的にはプロピレンオキサイドを澱粉に反応させることにより得ることができる(J Nutr 1998 128(5):848-54)。
ここで、澱粉の由来は、特に限定されないが、例えばワキシーコーン澱粉、コーン澱粉、小麦澱粉、米澱粉、糯米澱粉、馬鈴薯澱粉、甘露澱粉、タピオカ澱粉、サゴ澱粉由来のもの等が挙げられる。特にアミロペクチン含量が70重量%以上、好ましくは75〜100%、更に好ましくは90〜100%であるものが、糊液の透明性が高く、飲食品に応用した場合にその外観を損わず、適用範囲が広くなることより好ましい。中でもワキシーコーン澱粉、タピオカ澱粉が好ましい。
The hydroxypropylated starch of the present invention can be obtained by hydroxypropylating starch or processed starch by a conventional method. Specifically, it can be obtained by reacting propylene oxide with starch (J Nutr 1998 128 (5): 848-54).
Here, the origin of the starch is not particularly limited, and examples thereof include those derived from waxy corn starch, corn starch, wheat starch, rice starch, glutinous rice starch, potato starch, sweet dew starch, tapioca starch, and sago starch. In particular, the amylopectin content is 70% by weight or more, preferably 75 to 100%, more preferably 90 to 100%, the paste liquid has high transparency, and does not impair the appearance when applied to food and drink, It is more preferable that the application range becomes wider. Of these, waxy corn starch and tapioca starch are preferred.
本発明においては、当該ヒドロキシプロピル化澱粉として、市販品を用いることもできる。例えば、ナショナルフリジェックス(タピオカ由来、ナショナルスターチアンドケミカル社)、ナショナル1658(コーン由来、ナショナルスターチアンドケミカル社)、サームフロー(ワキシーコーン由来、ナショナルスターチアンドケミカル社)、サームテックス(ワキシーコーン由来、ナショナルスターチアンドケミカル社)等を用いることができる。 In this invention, a commercial item can also be used as the said hydroxypropylated starch. For example, National Frigex (from Tapioca, National Starch and Chemical), National 1658 (from Corn, National Starch and Chemical), Therm Flow (from Waxy Corn, National Starch and Chemical), Thermtex (from Waxy Corn, National Starch and Chemical Co.) can be used.
本発明のヒドロキシプロピル化澱粉には、他の加工処理を組み合わせることにより得られる加工ヒドロキシプロピル化澱粉も含まれる。組み合わせることのできる加工処理としては酢酸、オクテニルコハク酸、リン酸等のエステル化処理やヒドロキシプロピル化以外のカルボキシメチルエーテル化等によるエーテル化処理、トリメタリン酸塩、ヘキサメタリン酸塩、オキシ塩化リン、アジピン酸、エピクロルヒドリン等、常用の架橋剤を用いた架橋化処理、酸化処理、酸処理、漂白処理、湿熱処理、熱処理、酵素処理等が挙げられ、その内1種又は2種以上の加工を組み合わせても良い。中でも、エステル化処理が好ましく、リン酸化処理、リン酸架橋処理が好ましい。リン酸化の程度としては、結合リン含量が0.0001〜2%の範囲が挙げられるが、好ましくは0.0001〜0.5%、更に好ましくは0.0001〜0.2%であるものが食感等の面から好ましい。 The hydroxypropylated starch of the present invention includes processed hydroxypropylated starch obtained by combining other processing treatments. Processing that can be combined includes esterification of acetic acid, octenyl succinic acid, phosphoric acid, etc., etherification by carboxymethyl etherification other than hydroxypropylation, trimetaphosphate, hexametaphosphate, phosphorus oxychloride, adipic acid , Epichlorohydrin and the like, crosslinking treatment using a conventional crosslinking agent, oxidation treatment, acid treatment, bleaching treatment, wet heat treatment, heat treatment, enzyme treatment, etc. may be mentioned, of which one or more of them may be combined good. Of these, esterification treatment is preferred, and phosphorylation treatment and phosphoric acid crosslinking treatment are preferred. Examples of the degree of phosphorylation include a range in which the bound phosphorus content is 0.0001 to 2%, preferably 0.0001 to 0.5%, more preferably 0.0001 to 0.2%. It is preferable in terms of texture.
本発明においては、澱粉の由来、ヒドロキシプロピル化の程度或いは上記加工処理が異なるヒドロキシプロピル化澱粉を、単一又は複数混合して用いることができる。 In the present invention, hydroxypropylated starches having different starch origins, hydroxypropylation levels, or different processings can be used singly or in combination.
上記ヒドロキシプロピル化澱粉は、澱粉から簡単な工程で、高純度で比較的安価に製造でき、また安全性が高く、従来の食物繊維や難消化性澱粉と比較して、各種食品(パン、麺類、焼き菓子(ケーキ、クッキー等)、ゼリー類、飲料等)、医薬品、ペットフード等に用いたときの違和感がない。また、耐冷凍性に優れているので、解凍による変質が起こりにくいという利点を有する。 The above hydroxypropylated starch can be produced from starch in a simple process, with high purity and at a relatively low cost, and with high safety. Compared with conventional dietary fiber and resistant starch, various foods (bread, noodles) , Baked goods (cakes, cookies, etc.), jelly, beverages, etc.), pharmaceuticals, pet foods, etc. Moreover, since it is excellent in refrigeration resistance, it has the advantage that alteration by thaw is unlikely to occur.
斯くして得られたヒドロキシプロピル化澱粉は、後記実施例に示すように、持久力向上効果、抗疲労効果及び脂質燃焼促進効果を有することから、持久力向上剤、抗疲労剤又は脂質燃焼促進剤として使用でき、また、持久力向上剤、抗疲労剤又は脂質燃焼促進剤を製造するために使用することができる。そして、当該持久力向上剤、抗疲労剤又は脂質燃焼促進剤は、各効果を発揮する、ヒト若しくは動物用の医薬品、医薬部外品、食品として使用可能である。
また、当該持久力向上剤、抗疲労剤又は脂質燃焼促進剤を、医薬部外品や食品として使用する場合には、持久力向上や抗疲労、脂質燃焼促進等の生理機能をコンセプトとする機能性食品、美容食品、病者用食品、特定保健用食品に応用できる。
The hydroxypropylated starch thus obtained has an endurance improving effect, an anti-fatigue effect, and a lipid burning promoting effect, as shown in the examples below. It can be used as an agent and can be used to produce endurance improvers, anti-fatigue agents or lipid combustion promoters. The endurance improver, anti-fatigue agent, or lipid combustion accelerator can be used as a human or veterinary drug, quasi-drug, or food that exhibits each effect.
In addition, when the endurance improver, anti-fatigue agent or lipid combustion promoter is used as a quasi-drug or food, the function is based on physiological functions such as endurance improvement, anti-fatigue and lipid combustion promotion. It can be applied to sex foods, beauty foods, foods for the sick, and foods for specified health use.
本発明の持久力向上剤、抗疲労剤又は脂質燃焼促進剤(以下、持久力向上剤等とも言う)を医薬品として使用する場合は、例えば、錠剤、顆粒剤、カプセル剤、散剤等の経口用固形製剤や、内服液剤、シロップ剤、エリキシル剤等の経口用液体製剤とすることができる。経口用固形製剤を調製する場合には、本発明のヒドロキシプロピル化澱粉を単独で、又は他の薬学的に許容される賦形剤、必要に応じて結合剤、崩壊剤、滑沢剤、着色剤、矯味剤、矯臭剤等を加えた後、常法により錠剤、被覆錠剤、顆粒剤、散剤、カプセル剤等を製造することができる。また、経口用液体製剤を調製する場合は、矯味剤、緩衝剤、安定化剤、矯味剤、担体、希釈剤等を加えて常法により製造することができる。 When the endurance improver, anti-fatigue agent or lipid combustion accelerator (hereinafter also referred to as endurance improver) of the present invention is used as a pharmaceutical product, for example, for oral use such as tablets, granules, capsules, powders, etc. Oral liquid preparations such as solid preparations, internal use liquid preparations, syrup preparations and elixirs can be used. When preparing an oral solid preparation, the hydroxypropylated starch of the present invention alone or other pharmaceutically acceptable excipient, if necessary, binder, disintegrant, lubricant, coloring Tablets, coated tablets, granules, powders, capsules and the like can be produced by conventional methods after adding an agent, flavoring agent, flavoring agent and the like. Moreover, when preparing an oral liquid formulation, it can manufacture by a conventional method, adding a corrigent, a buffering agent, a stabilizer, a corrigent, a support | carrier, a diluent, etc.
本発明の持久力向上剤等を食品として用いる場合の形態としては、パン類、ケーキ類、麺類、菓子類、ゼリー類、冷凍食品、アイスクリーム類、乳製品、飲料などの各種食品の他、上述した経口投与製剤と同様の形態(錠剤、カプセル剤、シロップ等)が挙げられる。
種々の形態の食品を調製するには、ヒドロキシプロピル化澱粉を単独で、又は他の食品材料や、溶剤、軟化剤、油、乳化剤、防腐剤、香科、安定剤、着色剤、紫外線吸収剤、酸化防止剤、保湿剤、増粘剤等を適宜組み合わせて用いることができる。
In the case of using the endurance improver of the present invention as food, in addition to various foods such as breads, cakes, noodles, confectionery, jelly, frozen foods, ice creams, dairy products, beverages, Examples include the same forms (tablets, capsules, syrups, etc.) as the above-mentioned oral administration preparations.
To prepare various forms of food, hydroxypropylated starch alone or other food ingredients, solvents, softeners, oils, emulsifiers, preservatives, fragrances, stabilizers, colorants, UV absorbers , Antioxidants, humectants, thickeners, and the like can be used in appropriate combinations.
上記製剤中のヒドロキシプロピル化澱粉の含有量は、一般的に通常5〜100重量%、好ましくは10〜95重量%、特に20〜80重量%とするのが好ましい。
また、本発明の持久力向上剤等の成人1人当たりの1日の投与量(有効摂取量)は、本発明のヒドロキシプロピル化澱粉として、例えば一日当り0.01g/kg体重以上とするのが好ましく、特に0.1g/kg体重以上、更に0.4g/kg体重以上とするのが好ましい。
The content of hydroxypropylated starch in the preparation is generally usually 5 to 100% by weight, preferably 10 to 95% by weight, and particularly preferably 20 to 80% by weight.
Moreover, the daily dose (effective intake) per adult, such as the endurance improver of the present invention, is, for example, 0.01 g / kg body weight or more per day as the hydroxypropylated starch of the present invention. It is particularly preferable that the weight is 0.1 g / kg body weight or more, more preferably 0.4 g / kg body weight or more.
試験例1 ヒドロキシプロピル化澱粉の持久力向上効果
ヒドロキシプロピル化澱粉として、ナショナルフリジェックス(ヒドロキシプロピル化タピオカ澱粉:ナショナルスターチアンドケミカル社)を用いた。比較する澱粉として、タピオカ澱(日澱化学(株))を用いた。
上記の澱粉を5重量%となるように蒸留水に懸濁し、120℃にて15分間、オートクレーブ(湿熱処理)した後、室温まで放置冷却した。
Test Example 1 Endurance Improvement Effect of Hydroxypropylated Starch As the hydroxypropylated starch, National Friexex (hydroxypropylated tapioca starch: National Starch and Chemical Co., Ltd.) was used. Tapioca starch (Nissho Chemical Co., Ltd.) was used as the starch to be compared.
The above starch was suspended in distilled water to 5 wt%, autoclaved (wet heat treatment) at 120 ° C. for 15 minutes, and then allowed to cool to room temperature.
6週齢のC57BL/6J雄性マウス10匹(日本クレア)を前日より絶食させ、試験当日に、上記澱粉処理液を2mg澱粉/g体重となるように経口投与した。経口投与1時間後から28m/分の速度で走行運動を負荷し、限界走行時間(トレッドミルのベルト上で走れなくなるまでの時間)を測定した。各群の平均限界走行時間を表1に示した。 Ten 6-week-old C57BL / 6J male mice (CLEA Japan, Inc.) were fasted from the previous day, and on the day of the test, the above starch-treated solution was orally administered to 2 mg starch / g body weight. A running motion was loaded at a speed of 28 m / min from 1 hour after oral administration, and the limit running time (time until it could not run on the belt of the treadmill) was measured. Table 1 shows the average limit travel time for each group.
表1から、ヒドロキシプロピル化タピオカ澱粉溶液を経口投与したマウスでは、対照であるタピオカ澱粉溶液を投与したマウスと比較して限界走行時間が有意に延長しており、ヒドロキシプロピル化澱粉は持久力向上効果、抗疲労効果を有することがわかる。 From Table 1, the mice that were orally administered the hydroxypropylated tapioca starch solution had a significantly longer marginal running time than the mice that received the control tapioca starch solution, and hydroxypropylated starch improved endurance It turns out that it has an effect and an anti-fatigue effect.
試験例2 ヒドロキシプロピル化澱粉の脂質燃焼促進作用
ヒドロキシプロピル化澱粉として、サームフロー(ヒドロキシプロピル化ワキシーコーン澱粉:ナショナルスターチアンドケミカル社)を用いた。対照澱粉として、高アミロースコーン澱粉(ファイボース、日澱化学(株))を用いた。
上記の澱粉を50重量%となるように蒸留水に懸濁し、120℃にて15分間、オートクレーブ(湿熱処理)した後凍結乾燥し、試験澱粉を調製した。
Test Example 2 Lipid Combustion Promoting Action of Hydroxypropylated Starch Thermflow (hydroxypropylated waxy corn starch: National Starch and Chemical Co.) was used as the hydroxypropylated starch. As the control starch, high amylose corn starch (Phibose, Nippon Star Chemical Co., Ltd.) was used.
The above starch was suspended in distilled water to 50% by weight, autoclaved (wet heat treatment) at 120 ° C. for 15 minutes, and then freeze-dried to prepare a test starch.
8週齢のC57BL/6J雄性マウス(日本クレア)を1群10匹とし、表2に示す配合で調製した食餌を用い、容量2.5Lの代謝チャンバー内で飼育した。その際、マウスの酸素消費量(VO2)、呼吸商(RQ)は、Oxymaxシステム(コロンバス社)の8連チャンバーを用い、測定した。チャンバーへのAir流量を0.8L/分、チャンバーから排出するAirサンプリング量を0.4L/分とした。午後7:00にマウスをチャンバーに入れ、90時間、18分ごとに呼気測定を行った。脂質燃焼量は下記の式により算出した。
脂質燃焼量(mg/分/g体重)=1.67×(1−RQ)×VO2
90時間の総脂質燃焼量を表3に示した。
Eight-week-old C57BL / 6J male mice (CLEA Japan, Inc.) were grouped into 10 mice, and were bred in a metabolic chamber having a volume of 2.5 L using a diet prepared according to the formulation shown in Table 2. At that time, the oxygen consumption (VO 2 ) and the respiratory quotient (RQ) of the mouse were measured using an 8-series chamber of the Oxymax system (Columbus). The Air flow rate to the chamber was 0.8 L / min, and the Air sampling amount discharged from the chamber was 0.4 L / min. Mice were placed in the chamber at 7:00 pm and breath measurements were taken every 18 minutes for 90 hours. Lipid burning amount was calculated by the following formula.
Lipid burning amount (mg / min / g body weight) = 1.67 × (1−RQ) × VO 2
The total amount of lipid burn for 90 hours is shown in Table 3.
表3から、ヒドロキシプロピル化澱粉を10%配合した飼料を摂取したマウスでは、対照澱粉を配合した飼料を摂取したマウスと比較して、脂質燃焼量が高く、ヒドロキシプロピル化澱粉は脂質燃焼促進効果を有することがわかる。 From Table 3, the mice that ingested the diet containing 10% hydroxypropylated starch had higher lipid burning than the mice ingested the diet that contained control starch, and hydroxypropylated starch promoted lipid burning. It can be seen that
実施例1 製造例
(1)持久力向上/抗疲労/脂質燃焼促進用パスタ
小麦セモリナ粉(商品名「ジョーカーA」、日本製粉(株)製)7kgと熱処理ヒドロキシプロピル化タピオカ澱粉(商品名「ナショナルフリジェックス」、ナショナルスターチ&ケミカル(株)製)3kgに生地水分が30%になるように水を加えて混合し、パスタ用製麺機で製麺して生パスタを得た。これを麺水分が15%になるまで乾燥した後、120 ℃で10分間加熱殺菌した。その後、無菌環境下で50℃の無菌水に浸漬、含水膨潤させて包装し、持久力向上/抗疲労用パスタを得た。
Example 1 Production Example (1) Improving Endurance / Anti-fatigue / Fat Burning Promotion Pasta Wheat Semolina Powder (trade name “Joker A”, manufactured by Nippon Flour Mills Co., Ltd.) and heat treated hydroxypropylated tapioca starch (trade name “ Water was added to and mixed with 3 kg of “National Frigex” (manufactured by National Starch & Chemical Co., Ltd.) so that the moisture content of the dough was 30%, and noodles were made with a pasta noodle making machine to obtain fresh pasta. This was dried until the noodle water content was 15%, and then sterilized by heating at 120 ° C. for 10 minutes. Then, it was immersed in aseptic water at 50 ° C. in an aseptic environment, swollen with water, and packaged to obtain pasta for improving endurance / anti-fatigue.
(2) 持久力向上/抗疲労/脂質燃焼促進用パスタ
小麦セモリナ粉(商品名「ジョーカーA」、日本製粉(株)製)3kgと熱処理ヒドロキシプロピル化、ワキシーコーン澱粉(商品名「サームテックス」、ナショナルスターチ&ケミカル(株)製)7kgに生地水分が30%になるように水を加えて混合し、パスタ用製麺機で製麺、裁断して生パスタを得た。これを麺水分が15%になるまで乾燥した後、120 ℃で10分間加熱殺菌した。その後、無菌環境下で50℃の無菌水に浸漬、含水膨潤させて包装し、持久力向上/抗疲労用パスタを得た。
(2) Pasta for improving endurance / anti-fatigue / facilitating lipid combustion 3 kg of wheat semolina (trade name “Joker A”, manufactured by Nippon Flour Mills Co., Ltd.) and heat-treated hydroxypropylated, waxy corn starch (trade name “Thermtex”) (National Starch & Chemical Co., Ltd.) 7 kg, water was added and mixed so that the moisture content of the dough was 30%, and the pasta noodle making machine was cut into noodles and cut to obtain fresh pasta. This was dried until the noodle water content was 15%, and then sterilized by heating at 120 ° C. for 10 minutes. Then, it was immersed in aseptic water at 50 ° C. in an aseptic environment, swollen with water, and packaged to obtain pasta for improving endurance / anti-fatigue.
(3) 持久力向上/抗疲労/脂質燃焼促進用飲料
熱処理ヒドロキシプロピル化ワキシーコーン澱粉 (サームフロー:ナショナルスターチ&ケミカル(株)製)10重量%、ビタミンC 1%、クエン酸ナトリウム 0.07%、クエン酸 0.1%、グレープフルーツ果汁 5%、グレープフルーツ香料 0.05%、水(残量)を混合し、200mlの持久力向上/抗疲労/脂質燃焼促進用飲料を製造した。
(3) Beverage for improving endurance / anti-fatigue / facilitating lipid burning Heat treated hydroxypropylated waxy corn starch (Therm Flow: National Starch & Chemical Co., Ltd.) 10% by weight, vitamin C 1%, sodium citrate 0.07% Then, citric acid 0.1%, grapefruit juice 5%, grapefruit flavor 0.05%, and water (remaining amount) were mixed to prepare 200 ml of a beverage for improving endurance / anti-fatigue / lipid combustion promotion.
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