JP5379005B2 - 光吸収係数の決定 - Google Patents
光吸収係数の決定 Download PDFInfo
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- JP5379005B2 JP5379005B2 JP2009529810A JP2009529810A JP5379005B2 JP 5379005 B2 JP5379005 B2 JP 5379005B2 JP 2009529810 A JP2009529810 A JP 2009529810A JP 2009529810 A JP2009529810 A JP 2009529810A JP 5379005 B2 JP5379005 B2 JP 5379005B2
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N29/00—Investigating or analysing materials by the use of ultrasonic, sonic or infrasonic waves; Visualisation of the interior of objects by transmitting ultrasonic or sonic waves through the object
- G01N29/22—Details, e.g. general constructional or apparatus details
- G01N29/24—Probes
- G01N29/2418—Probes using optoacoustic interaction with the material, e.g. laser radiation, photoacoustics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
- A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1702—Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/47—Scattering, i.e. diffuse reflection
- G01N21/4795—Scattering, i.e. diffuse reflection spatially resolved investigating of object in scattering medium
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
- A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1702—Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids
- G01N2021/1706—Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids in solids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/024—Mixtures
- G01N2291/02466—Biological material, e.g. blood
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2291/00—Indexing codes associated with group G01N29/00
- G01N2291/02—Indexing codes associated with the analysed material
- G01N2291/024—Mixtures
- G01N2291/02475—Tissue characterisation
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- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Biochemistry (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Optics & Photonics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Biophysics (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Acoustics & Sound (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Ultra Sonic Daignosis Equipment (AREA)
- Investigating Or Analyzing Materials By The Use Of Ultrasonic Waves (AREA)
Description
・測定位置に加熱光ビームが送られる前および後にそれぞれ測定された第一および第二のパルス・エコーから、前記測定位置における関心のある光学的係数を決定する「評価ユニット」。評価ユニットは典型的には、専用のハードウェアおよび/またはソフトウェアをもつマイクロコンピュータによって実現される。たとえば加熱光ビームのあとに光放出のない期間が続いて、その間に第二のパルス・エコーが測定されてもよい。あるいはたとえば加熱光ビームがさらなる光ビーム(特に前記加熱光ビームと同じ性質のもの)によって継続され、該さらなる光ビームが第二のパルス・エコーの測定の間、優勢となってもよい。
・測定位置に送られる超音波パルスの第一のパルス・エコー(first pulse echoes)を測定する。
・前記測定位置に加熱光ビームを送る。
・加熱光ビームが送られたのちに前記測定位置に送られる超音波パルスの第二のパルス・エコー(second pulse echoes)を測定する。
・前記第一および第二のパルス・エコーから関心のある光学的係数を決定する。
1)光照射露光の前およびすぐ後に超音波パルス・エコー画像が取得される。ここで、照射の前および後の一つのパルス・エコー線が、その線に沿ったOACを得るために十分でありうる。
2)同じOACを共有する組織区画に属する少なくとも二つの空間的に離間した点において温度変化が同定される。
3)前述の点の間の温度変化の比およびそれらの点の間隔から、前記温度変化およびその深さ情報の少なくとも一つと組み合わせて、光吸収係数が得られる。関連する点の最小の必要とされる間隔は、温度取得プロセスの解像度によってのみ決定される。
Claims (10)
- 対象中の少なくとも一つの測定位置における光学的係数の決定のための検査装置であって、
・前記測定位置に加熱光ビームを選択的に送る光源と;
・前記測定位置に送られた超音波パルスのパルス・エコーを測定する超音波スキャナと;
・前記測定位置に加熱光ビームを送る前および後に測定されたパルス・エコーから前記測定位置における前記光学的係数を決定する評価ユニットとを有しており、
前記評価ユニットが、前記測定位置における前記加熱光ビームの光強度を決定する強度推定モジュールを有することを特徴とする、
検査装置。 - 前記評価ユニットが、前記加熱光ビームによって前記対象中に誘起された温度上昇の空間的マップを決定する温度マッピング・モジュールを有することを特徴とする、
請求項1記載の検査装置。 - 前記評価ユニットが、前記対象中の有効光散乱属性の空間的マップを推定する散乱マッピング・モジュールを有することを特徴とする、
請求項1記載の検査装置。 - 前記光学的係数が、光吸収係数および/または光散乱係数を含むことを特徴とする、
請求項1記載の検査装置。 - 前記加熱光ビームが所与のスペクトル組成の光のみを含むことを特徴とする、
請求項1記載の検査装置。 - 前記光源および前記超音波スキャナが平行な放射方向をもつことを特徴とする、
請求項1記載の検査装置。 - 特定の光吸収属性をもつ造影剤を前記対象中に注入する注入装置を有することを特徴とする、
請求項1記載の検査装置。 - 対象中の少なくとも一つの測定位置における光学的係数の決定方法であって:
・前記測定位置に送られた超音波パルスの第一のパルス・エコーを測定する段階と;
・前記測定位置に加熱光ビームを送る段階と;
・前記測定位置に送られた超音波パルスの第二のパルス・エコーを測定する段階と;
・前記第一および第二のパルス・エコーから前記光学的係数を決定する段階とを有しており、
前記第一および第二のパルス・エコーから前記対象内の温度上昇のマップが決定され、
前記温度上昇のマップから前記測定位置における前記加熱光ビームの強度が決定される、
方法。 - 前記光学的係数が前記対象内の複数の位置において決定されることを特徴とする、
請求項8記載の方法。 - 対象内の少なくとも一つの測定位置における光学的係数の決定のためのコンピュータ・プログラムが記憶されている記録担体であって、前記プログラムが請求項8記載の方法を実行するよう適応されている、記録担体。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06121524.0 | 2006-09-29 | ||
EP06121524 | 2006-09-29 | ||
PCT/IB2007/053763 WO2008038182A2 (en) | 2006-09-29 | 2007-09-18 | Ultrasonic determination of optical absorption coefficients |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2010504791A JP2010504791A (ja) | 2010-02-18 |
JP5379005B2 true JP5379005B2 (ja) | 2013-12-25 |
Family
ID=39145029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009529810A Expired - Fee Related JP5379005B2 (ja) | 2006-09-29 | 2007-09-18 | 光吸収係数の決定 |
Country Status (7)
Country | Link |
---|---|
US (1) | US8328721B2 (ja) |
EP (1) | EP2074418B1 (ja) |
JP (1) | JP5379005B2 (ja) |
CN (1) | CN101523203B (ja) |
BR (1) | BRPI0717548A2 (ja) |
RU (1) | RU2437089C2 (ja) |
WO (1) | WO2008038182A2 (ja) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4279328B2 (ja) * | 2007-05-07 | 2009-06-17 | 株式会社日立製作所 | 超音波撮像システム |
US8882672B2 (en) | 2008-12-29 | 2014-11-11 | Perseus-Biomed Inc. | Method and system for tissue imaging and analysis |
US8870772B2 (en) | 2008-12-29 | 2014-10-28 | Perseus-Biomed Inc. | Method and system for tissue recognition |
US8864669B2 (en) | 2008-12-29 | 2014-10-21 | Perseus-Biomed Inc. | Method and system for tissue imaging and analysis |
JP5648957B2 (ja) | 2010-10-22 | 2015-01-07 | 浜松ホトニクス株式会社 | 乳房計測装置 |
US20150250388A1 (en) * | 2013-07-10 | 2015-09-10 | The Board Of Trustees Of The Leland Stanford Junior University | Remote sensing, imaging, or screening of embedded or concealed objects |
DE102014107261A1 (de) * | 2014-05-22 | 2015-11-26 | Nirlus Engineering Ag | Verfahren zur nichtinvasiven optischen Messung von Eigenschaften von fließendem Blut |
US20170079625A1 (en) | 2014-05-23 | 2017-03-23 | Koninklijke Philips N.V. | Motion gated-ultrasound thermometry using adaptive frame selection |
JP6512969B2 (ja) * | 2015-07-06 | 2019-05-15 | キヤノン株式会社 | 処理装置、光音響装置、処理方法、及びプログラム |
US9987089B2 (en) | 2015-07-13 | 2018-06-05 | University of Central Oklahoma | Device and a method for imaging-guided photothermal laser therapy for cancer treatment |
KR101734984B1 (ko) | 2015-12-10 | 2017-05-12 | 한밭대학교 산학협력단 | 광음향 측정기를 이용하여 주파수 영역에서 광흡수계수를 산출하는 방법 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
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JPS60199429A (ja) * | 1984-03-24 | 1985-10-08 | アロカ株式会社 | 生体内温度計測装置 |
JPH03258251A (ja) * | 1990-03-09 | 1991-11-18 | Gijutsu Kenkyu Kumiai Iryo Fukushi Kiki Kenkyusho | 温度分布測定装置 |
JP2001145628A (ja) * | 1999-11-19 | 2001-05-29 | Aloka Co Ltd | 音波計測装置 |
IL138073A0 (en) * | 2000-08-24 | 2001-10-31 | Glucon Inc | Photoacoustic assay and imaging system |
EP1364196A4 (en) * | 2001-01-26 | 2008-09-03 | Sensys Medical Inc | NONINVASIVE MEASUREMENT OF GLUCOSE BY THE OPTICAL PROPERTIES OF TISSUE |
US7179449B2 (en) * | 2001-01-30 | 2007-02-20 | Barnes-Jewish Hospital | Enhanced ultrasound detection with temperature-dependent contrast agents |
US20050085725A1 (en) * | 2001-08-09 | 2005-04-21 | Ron Nagar | Photoacoustic assay and imaging system |
US6692438B2 (en) * | 2001-12-18 | 2004-02-17 | Koninklijke Philips Electronics Nv | Ultrasonic imaging system and method for displaying tissue perfusion and other parameters varying with time |
WO2004086965A1 (en) | 2003-04-01 | 2004-10-14 | Glucon Inc. | Photoacoustic assay method and apparatus |
CA2671101C (en) * | 2006-01-20 | 2016-06-14 | Seno Medical Instruments, Inc. | Quantitative optoacoustic tomography with enhanced contrast |
JP4909132B2 (ja) * | 2006-08-28 | 2012-04-04 | 公立大学法人大阪府立大学 | 光トモグラフィ装置 |
JP4820239B2 (ja) * | 2006-08-28 | 2011-11-24 | 公立大学法人大阪府立大学 | 光トモグラフィ装置用プローブ |
US8108030B2 (en) * | 2006-10-20 | 2012-01-31 | Board Of Regents, The University Of Texas System | Method and apparatus to identify vulnerable plaques with thermal wave imaging of heated nanoparticles |
WO2009045885A2 (en) * | 2007-10-02 | 2009-04-09 | Board Of Regents, The University Of Texas System | Real-time ultrasound monitoring of heat-induced tissue interactions |
-
2007
- 2007-09-18 US US12/442,729 patent/US8328721B2/en not_active Expired - Fee Related
- 2007-09-18 BR BRPI0717548-5A patent/BRPI0717548A2/pt not_active Application Discontinuation
- 2007-09-18 CN CN2007800364557A patent/CN101523203B/zh not_active Expired - Fee Related
- 2007-09-18 EP EP07826422A patent/EP2074418B1/en not_active Not-in-force
- 2007-09-18 WO PCT/IB2007/053763 patent/WO2008038182A2/en active Application Filing
- 2007-09-18 JP JP2009529810A patent/JP5379005B2/ja not_active Expired - Fee Related
- 2007-09-18 RU RU2009116237/28A patent/RU2437089C2/ru not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
BRPI0717548A2 (pt) | 2013-10-22 |
RU2437089C2 (ru) | 2011-12-20 |
US8328721B2 (en) | 2012-12-11 |
WO2008038182A3 (en) | 2008-06-05 |
RU2009116237A (ru) | 2010-11-10 |
WO2008038182A2 (en) | 2008-04-03 |
US20100043557A1 (en) | 2010-02-25 |
CN101523203A (zh) | 2009-09-02 |
CN101523203B (zh) | 2012-09-05 |
EP2074418B1 (en) | 2013-03-06 |
JP2010504791A (ja) | 2010-02-18 |
EP2074418A2 (en) | 2009-07-01 |
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