JP5378175B2 - Automatic analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To heighten reliability of an analysis result in an automatic analyzer. <P>SOLUTION: Steam generated in a steam generation device 30 is discharged into a reaction cell from a steam cleaning nozzle 202 having a cover 200a for covering an opening the reaction cell 10 to perform the cleaning, and a temperature of the reaction cell is monitored thereafter. Hereby, dirt adhering onto an inner wall of the reaction cell is washed away completely by high-temperature high-pressure steam, to improve a cleaning effect. Consequently, a function of a protein or enzyme of a sample subjected to the former analysis is vanished in the reaction cell to be reused, and reliability of an analysis result can be heightened, and a using amount of a detergent can be reduced. If the temperature of the reaction cell after steam cleaning is unusually high, the reaction cell is not reused, to thereby prevent beforehand generation of an error in the analysis result. <P>COPYRIGHT: (C)2011,JPO&amp;INPIT

Description

  The present invention relates to an automatic analyzer that automatically measures a component, an activity value, and the like of a sample by reacting the sample with a reagent.

  The automatic analyzer is a device that mixes a reagent with a sample such as blood or urine and reacts, and automatically analyzes the reaction state of the sample by, for example, spectroscopic analysis. This automatic analyzer is widely used in hospitals and medical examination institutions because it can perform a component analysis of a large number of items for a large number of samples in a short time.

  By the way, there is a strong demand for reducing the amount of a sample to be analyzed by an automatic analyzer recently. The reason is that, of course, you don't want to waste blood that is important to you, but if you have a large amount of sample, you need a lot of reagent to react with that sample. . That is, in the operation of the automatic analyzer, since the ratio of the reagent to the running cost is large, there is a circumstance that it is desired to reduce the amount of the reagent to be used as much as possible in order to reduce the running cost.

  The sample is dispensed into the reaction cell by a predetermined amount, and a predetermined amount of reagent according to the inspection item is dispensed and stirred to react. After the measurement is completed, the reaction cell is washed and reused for the next measurement. Is done. Therefore, in order to obtain an accurate reaction result, it is important that the previously used sample or reagent does not remain in the reaction cell to be used. Therefore, conventionally, the reaction cell after discharging the used reaction liquid has been washed sequentially several times using an alkaline detergent, an acidic detergent, pure water, or the like (see, for example, Patent Document 1).

  Moreover, when inject | pouring the washing | cleaning liquid into the reaction cell, the proposal which controls so that a washing | cleaning liquid flows along the inner wall side surface of a reaction cell was also made | formed (for example, refer patent document 2).

  Furthermore, it has also been proposed that a dispensing probe used for dispensing a sample or the like into a reaction cell is cleaned using high-temperature steam regardless of the drug (see, for example, Patent Document 3). In the cleaning of the dispensing probe with steam, the dispensing probe itself is heated to a high temperature, or the piping flow path leading to the dispensing probe is heated to a high temperature, so that the cleaning liquid boils instantaneously and expands rapidly due to boiling. Steam is discharged from the tip of the dispensing probe to clean the inside of the dispensing probe.

JP 2002-90372 A JP 2008-224538 A Japanese Patent Laid-Open No. 11-94843

  By the way, cleaning of the dispensing probe with steam is expected to eliminate the functions of proteins and enzymes contained in the sample to be dispensed, so the dispensing probe is washed in preparation for the next sample dispensing. Therefore, it is an effective means and is also desired to be applied to the cleaning of the reaction cell. However, in order to apply the cleaning means disclosed in Patent Document 3 to cleaning of reaction cells, it is difficult to generate steam by heating individual reaction cells, and the temperature of the reaction cells becomes high due to steam cleaning. If the reaction cell is used continuously, there may be an error in the analysis results, and the cleaning vapor may be scattered from the reaction cell and contaminate other reaction cells or contaminate other places. There were many problems.

  The present invention has been made for the purpose of providing an automatic analyzer that solves such problems.

In order to solve the above-mentioned problems, the invention according to claim 1 generates steam in an automatic analyzer that analyzes a component of the sample by reacting a mixture of a sample and a reagent in a reaction cell. Steam generating means, a nozzle for discharging the steam generated by the steam generating means, nozzle driving means for raising or lowering the nozzle and taking the nozzle into and out of the reaction cell, and the nozzle by the nozzle driving means And a cover that closes the inside of the reaction cell by coming into contact with the reaction cell when lowered by a predetermined length, and the nozzle is attached to the reaction cell by the nozzle driving means. When it further descends after contact, it slides against the cover and maintains the substantially closed state of the reaction cell.

  According to the present invention, the cleaning effect can be further improved by providing a steam generator and discharging the high-temperature and high-pressure steam generated here into the reaction cell.

It is the perspective view which showed the schematic structure of the analysis part of the automatic analyzer which concerns on this invention. It is the perspective view which showed an example of the washing | cleaning unit provided in the automatic analyzer which concerns on this invention. It is the system diagram which showed an example of the path | route which supplies the vapor | steam generator with which the automatic analyzer which concerns on this invention is equipped, and the vapor | steam generate | occur | produced with this vapor generator to a washing | cleaning unit. It is explanatory drawing which showed an example of the cover with which the steam cleaning nozzle was equipped, and an expansion-contraction member. It is explanatory drawing shown in order to demonstrate the operation | movement process of a vapor | steam washing nozzle. It is explanatory drawing of the operation | movement process which showed the state which the vapor cleaning nozzle further lowered | hung from the state of FIG. It is a timing chart explaining the discharge timing of the steam according to the vertical movement of the steam cleaning nozzle. It is explanatory drawing explaining the discharge direction of the vapor | steam from a vapor | steam washing nozzle. It is explanatory drawing of the other Example of the washing | cleaning unit which changed the arrangement | sequence of the washing nozzle.

  Hereinafter, embodiments of an automatic analyzer according to the present invention will be described in detail with reference to FIGS. In these drawings, the same portions are denoted by the same reference numerals.

  FIG. 1 is a perspective view showing a schematic configuration of an analysis unit of the automatic analyzer.

  The automatic analyzer includes a reaction disk 11 equipped with a large number of reaction cells 10, a sample disk 12 containing a large number of sample containers 12a, a first reagent container 13, a second reagent container 14, a sample dispensing mechanism 15, and a first reagent. The dispensing mechanism 16, the second reagent dispensing mechanism 17, the first stirring mechanism 18, the second stirring mechanism 19, the washing unit 20, the measurement unit 22, and the like, and the operation of each component device such as these units and mechanisms, It is controlled by an analyzer control unit (see FIG. 3) not shown in FIG. As an option, an electrode 21 can also be arranged.

  The reaction disk 11 is formed in a ring shape and is equipped with a large number of reaction cells 10 in the circumferential direction, and performs an intermittent rotation operation that rotates or stops by a predetermined angle according to a set program. . A sample disk 12 containing a large number of sample containers 12a containing samples to be analyzed is arranged near the reaction disk 11. The first reagent storage 13 is concentrically arranged inside the reaction disk 11 and stores a large number of reagent containers 13a containing reagents. Similarly, a second reagent storage 14 storing a large number of reagent containers 14 a containing reagents is arranged in the vicinity of the reaction disk 11 at a predetermined interval.

  A sample dispensing mechanism 15 is disposed between the reaction disk 11 and the sample disk 12. The sample dispensing mechanism 15 rotates between the reaction disk 11 and the sample disk 12 so as to draw an arc around the support column 15a. A first reagent dispensing mechanism 16 is disposed in the vicinity of the outer periphery of the reaction disk 11, and a second reagent dispensing mechanism 17 is disposed between the reaction disk 11 and the second reagent storage 14. The first reagent dispensing mechanism 16 and the second reagent dispensing mechanism 17 are also arranged between the reaction disk 11 and the first reagent container 13 or between the reaction disk 11 and the second reagent container 14 with the support columns 16a and 17a as axes. Rotate to draw an arc. Further, a first stirring mechanism 18, a second stirring mechanism 19, a cleaning unit 20, and an electrode 21 are disposed near the outer periphery of the reaction disk 11, and a measurement unit 22 is disposed at a predetermined position of the reaction disk 11.

  The sample disk 12 is formed in a disk shape, and the desired one of the sample container 12a is moved to the suction position of the sample dispensing mechanism 15 by rotating around its axis. The sample dispensing mechanism 15 has a needle-like sampling probe 15c (hereinafter simply referred to as probe 15c) on the tip side of a sampling arm 15b (hereinafter simply referred to as arm 15b). Then, by positioning the probe 15c at a predetermined suction position of the sample disk 12 and lowering the support column 15a, the probe 15c is lowered into the sample container 12a to suck the sample. Thereafter, the column 15a is raised, the arm 15b is rotated to the reaction disk 11 side, and the sample is discharged into a predetermined reaction cell 10 accommodated in the reaction disk 11.

  Even when the sample is discharged, the sample dispensing mechanism 15 lowers the support column 15a at a predetermined discharge position so that the probe 15c is lowered into the reaction cell 10 and the sample is removed from the probe 15c. Is discharged. Further, a tube is connected to the base of the probe 15c, that is, the arm 15b side. This tube passes through the arm 15b, further passes through the support column 15a, and the other end is connected to a pump (not shown).

  The reaction disk 11 rotates about its axis, and the predetermined reaction cell 10 is moved to the reagent discharge position of the first reagent dispensing mechanism 16 and the second reagent dispensing mechanism 17.

  The first reagent storage 13 and the second reagent storage 14 are both formed in an annular shape and rotate around the axis thereof. Desired reagent containers 13a and 14a stored in the first reagent storage 13 and the second reagent storage 14 are respectively arranged for the first reagent. The injection mechanism 16 and the second reagent dispensing mechanism 17 are moved to the suction position. Each of the first reagent dispensing mechanism 16 and the second reagent dispensing mechanism 17 has a needle-like nozzle, and the reagent is supplied from predetermined reagent containers 13a and 14a of the first reagent container 13 and the second reagent container 14, respectively. Aspirate and dispense a predetermined amount of the reagent into a predetermined reaction cell 10 accommodated in the reaction disk 11.

  When the reaction cell 10 reaches the first stirring position and the second stirring position by the rotation operation of the reaction disk 11, the first stirring mechanism 18 and the second stirring mechanism 19 are discharged into the corresponding reaction cell 10. The mixture is mixed with a reagent with a stir bar to promote the reaction. Furthermore, when the reaction cell 10 reaches the position of the measurement unit 22 as the reaction disk 11 rotates, the components of the liquid mixture in the reaction cell 10 are spectrally analyzed by the measurement unit 22. When the reaction cell 10 reaches the position of the cleaning unit 20 after the analysis is completed, the mixed liquid in the reaction cell 10 is first discharged, and the reaction cell 10 is sequentially cleaned by the cleaning unit 20 for analysis of the next sample. Provided.

  The cleaning unit 20 is disposed in the vicinity of the outer periphery of the reaction disk 11, and an example is shown in a perspective view in FIG. That is, the cleaning unit 20 includes a plurality of cleaning devices 201 to 208 positioned immediately above the reaction cell 10 that moves in accordance with the rotation operation of the reaction disk 11. On the other hand, a plurality of stages of cleaning operations are sequentially performed.

  The cleaning unit 20 includes, for example, a first cleaning nozzle 201, a second cleaning nozzle 202, a third cleaning nozzle 203, a fourth cleaning nozzle 204, a fifth cleaning nozzle 205, and a sixth cleaning order in order from the left side of FIG. The cleaning nozzle 206, the suction nozzle 207, and the drying nozzle 208 are arranged side by side, and the reaction cell 10 is positioned in each cleaning nozzle, and thus operates as follows.

  First, when the reaction cell 10 is positioned at the first cleaning nozzle 201, pure water is injected into the reaction cell 10 in which the high-concentration mixed liquid remains, and these are sucked and discharged. This first cleaning nozzle 202 is referred to as a first cleaning line. Next, in the second cleaning nozzle 202, high-pressure and high-temperature steam is discharged into the reaction cell 10 to wash away dirt adhering to the inner wall of the reaction cell 10, and proteins and enzymes contained in the sample remain. If so, these functions are lost. Therefore, the second cleaning nozzle 202 is referred to as a steam cleaning line.

  Subsequently, the third cleaning nozzle 203 discharges and cleans the alkaline detergent into the reaction cell 10 and then sucks and discharges it. Therefore, the third cleaning nozzle 203 is referred to as an alkali cleaning line. Further, the fourth cleaning nozzle 204 discharges and cleans the acidic detergent into the reaction cell 10, and then sucks and discharges it. Therefore, the fourth cleaning nozzle 204 is referred to as an acidic cleaning line. Thereafter, in the fifth cleaning nozzle 205, pure water is discharged into the reaction cell 10 for cleaning, and then this is sucked and discharged. Therefore, the fifth cleaning nozzle 205 is referred to as a pure water cleaning line. Further, since the sixth cleaning nozzle 206 repeats cleaning with pure water, the sixth cleaning nozzle 206 is also referred to as a pure water cleaning line.

  Thereafter, the suction nozzle 207 (suction line) discharges pure water to empty the reaction cell 10, and finally the reaction cell 10 wet with pure water (cleaning liquid) is dried by the drying nozzle 208 (drying line). Let Note that the sixth cleaning nozzle 206 inspects whether or not the cleaning is sufficient by applying light to the reaction cell 10 into which pure water has been injected and measuring the transmittance. As described above, the cleaning unit 20 performs cleaning by sequentially injecting steam, various detergents, and the like into the reaction cell 10 while repeating vertical movement according to the rotation of the reaction disk 11.

  The cleaning unit 20 operates such that each cleaning nozzle performs a predetermined cleaning operation all at once while repeating vertical movement at a predetermined timing under the control of the analyzer control unit (see FIG. 3). However, the cleaning unit 20 itself is fixed so as to hold the cleaning instruments constituting each cleaning line, and the cleaning instruments constituting each cleaning line are individually controlled by the analyzer control unit (see FIG. 3). Then, the cleaning operation may be performed while repeating the vertical movement at a predetermined timing.

  Now, in the above-described cleaning unit 20, an alkali cleaning line, an acidic cleaning line, a pure water cleaning line, a suction line, a drying line, etc. are conventionally provided in an automatic analyzer, and the automatic analyzer of the present invention. Then, the second cleaning nozzle 202 is newly provided as a steam cleaning line. Then, next, the detail of the steam generator for supplying a steam to a steam cleaning line and this steam cleaning line is demonstrated.

  FIG. 3 is a system diagram showing an embodiment of a steam generator provided in the automatic analyzer according to the present invention and a path for supplying the steam generated by the steam generator to the cleaning unit 20.

  The steam generator 30 includes a sealed container 31, a heater 32 provided in the sealed container 31, and a temperature sensor 33, and a water supply pipe 34 and a steam discharge pipe 35 are coupled to the sealed container 31. The water supply pipe 34 is connected to a supply control valve 41, and the supply control valve 41 is connected to the cleaning water tank 40 via a pump 42. The cleaning water tank 40 stores cleaning pure water to be supplied to the pure water cleaning lines 205 and 206 of the cleaning unit 20. This pure water is also supplied to the sealed container 31 by the pump 42. The pure water introduced into the sealed container 31 is heated by the heater 32 to generate steam, and the temperature of the steam is monitored by the temperature sensor 33.

  The output signal of the temperature sensor 33 provided in the sealed container 31 is supplied to the analyzer control unit 50. The analyzer control unit 50 performs a central function of controlling the operation of the entire automatic analyzer, and includes the heater 32 of the steam generator 30, the opening and closing of the supply control valve 41 and the discharge control valve 43, and the pump 42. Also controls the driving of the. Further, a nozzle drive unit 60 is provided to drive the vertical movement of the cleaning unit 20 and a cleaning instrument constituting each cleaning line. The analyzer control unit 50 also controls the operation of the nozzle driving unit 60. .

  On the other hand, a discharge control valve 43 is connected to the steam discharge pipe 35 connected to the sealed container 31. Therefore, the steam generated in the sealed container 31 is supplied to the second cleaning nozzle 202 (steam cleaning line) via the discharge control valve 43. It should be noted that when discharging steam from the second cleaning nozzle 202 (steam cleaning line) to the reaction cell 10, the reaction cell is formed by the cover 200a and the expansion member 200b in order to prevent the steam from scattering out of the reaction cell 10. 10 open ends are covered. Details of these will be described later. The supply control valve 41 and the discharge control valve 43 are, for example, electromagnetically controlled to open and close. If the steam in the sealed container 31 is used by opening the discharge control valve 43, the supply control valve 41 is opened. At the same time, the pump 42 is operated to supply pure water from the washing water tank 40 to the sealed container 31.

  Further, in the automatic analyzer according to the present invention, a temperature sensor 70 for detecting the temperature of the reaction cell 10 is provided in the vicinity of the cleaning unit 20, and an output signal of this temperature sensor 70 is also sent to the analyzer controller 50. Supplied. The temperature sensor 70 detects the temperature of the reaction cell 10 after being cleaned by the second cleaning nozzle 202 (steam cleaning line). The reason is that the reaction of the sample is usually performed in an environment of about 36 ° C., so that if the temperature of the reaction cell 10 is abnormally higher than this temperature, an error occurs in the analysis result of the sample. Is expected. Therefore, in such a case, the operation of the automatic analyzer is controlled by the analyzer control unit 50 so that the reaction cell 10 is not used for the next analysis. Further, for the high-temperature reaction cell 10 that has not been used for analysis by the control by the analysis control unit 50, internal cleaning by the cleaning unit 20 is started again after a certain period of time, and after the steam cleaning, the temperature sensor 70 is again connected. The temperature of the reaction cell 10 is detected. At that time, if the detected temperature is about 36 ° C., the analyzer control unit 50 controls to use the reaction cell 10 for the next analysis. Therefore, the temperature sensor 70 only needs to detect the temperature of the reaction cell 10 between the steam cleaning line and the drying line in the cleaning unit 20.

  Now, functions of the cover 200a and the elastic member 200b provided in the steam cleaning line will be described with reference to FIGS.

  FIG. 4 is a longitudinal sectional view showing the second cleaning nozzle 202 and the reaction cell 10 located thereunder in the vicinity of the cleaning unit 20. The reaction cell 10 has, for example, a U-shaped cross-section with an open upper end, and a cover 200a that closes the opening at the upper end of the reaction cell 10 is provided with the second cleaning nozzle 202 penetrating in the center. . The second cleaning nozzle 202 is slidable with respect to the cover 200a, and expands and contracts on the cover 200a according to the vertical movement of the second cleaning nozzle 202 by the nozzle driving unit 60 shown in FIG. The member 200b is interposed.

  Therefore, when the second cleaning nozzle 202 is lowered from the state of FIG. 4, the cover 200 a and the elastic member 200 b are also lowered together with the second cleaning nozzle 202, and the cover 200 a is opened at the upper end of the reaction cell 10 as shown in FIG. 5. To come into contact. At this time, the length of the elastic member 200b is D0. When the second cleaning nozzle 202 is further lowered from this state, the cover 200a is pressed by the expansion / contraction member 200b while being pressed against the opening at the upper end of the reaction cell 10, and as shown in FIG. The tip is inserted into the reaction cell 10. The length dimension of the elastic member 200b at this time is D1 (however, D0> D1). Thereafter, when the second cleaning nozzle 202 is raised, the state shown in FIG. 4 is restored. The cover 200a is formed of, for example, a heat resistant resin.

  Next, the discharge of steam according to the vertical movement of the second cleaning nozzle 202 will be described with reference to the timing chart of FIG. 7A shows the lowering operation timing of the second cleaning nozzle 202, FIG. 7B shows the vapor discharge operation timing of the second cleaning nozzle 202, and FIG. 7C shows the second cleaning nozzle 202. The ascending operation timing of the nozzle 202 is shown, and the horizontal axis t indicates time.

  Now, the second cleaning nozzle 202 that has been stopped until then starts to descend at time t1 by the operation of the nozzle drive unit 60 based on the instruction of the analyzer control unit 50. When the second cleaning nozzle 202 starts to descend, the cover 200a comes into contact with the opening at the upper end of the reaction cell 10 at time t2, and the state shown in FIG. At this timing, the analyzer control unit 50 opens the discharge control valve 43 and introduces the vapor in the sealed container 31 to the second cleaning nozzle 202. Therefore, high-temperature and high-pressure steam is discharged from the second cleaning nozzle 202 into the reaction cell 10 and cleaning is started.

  Thereafter, the second cleaning nozzle 202 is lowered until the time t3 is reached, and the discharge of steam is continued during this time. The state at this time is as shown in FIG. When the time t3 is reached, the analyzer control unit 50 closes the discharge control valve 43, stops the discharge of the vapor, and raises the second cleaning nozzle 202. Further, at time t4, the rising of the second cleaning nozzle 202 is stopped, and the steam cleaning operation for the reaction cell 10 is ended. In addition, at the time t3 when the second cleaning nozzle 202 starts to rise, the vapor discharge is still continued, and slightly before the cover 200a moves away from the upper end opening of the reaction cell 10 as the second cleaning nozzle 202 rises. The discharge control valve 43 may be closed.

  Note that the second cleaning nozzle 202 has an opening at the tip, and the steam is discharged from the opening. For example, the nozzle is arranged so as to discharge the steam in the left-right direction of the nozzle indicated by an arrow in FIG. An opening may be formed in the substrate. Further, an opening may be formed in the nozzle so as to discharge steam in the horizontal direction of the nozzle indicated by arrows in FIG. 8B, that is, front and rear, right and left, and when the reaction cell 10 is rectangular. In addition, openings may be formed in the nozzles so that steam is discharged in the four corner directions indicated by arrows in FIG.

  As described above in detail, according to the present invention, the steam generator 30 is provided, and the high-temperature and high-pressure steam generated here is discharged into the reaction cell 10, so that dirt adhering to the inner wall of the reaction cell is removed. It can be washed out to every corner, and the cleaning effect can be further improved. Therefore, regarding the reaction cell 10 to be reused, the functions of proteins, enzymes, etc. of the sample previously subjected to analysis can be lost, a good analysis result can be obtained, and the amount of detergent used can be reduced. Further, by providing the cover 200a on the nozzle of the steam cleaning line, it is possible to prevent the cleaning steam from being scattered and mixed into other reaction cells 10 or contaminating other places.

  Further, when the temperature of the reaction cell 10 after the steam cleaning is detected by the temperature sensor 70 and the reaction cell 10 becomes a high temperature exceeding a predetermined temperature, the reaction cell 10 is not subjected to the next analysis. As described above, an automatic analyzer with high reliability can be provided, for example, by rejecting the analyzer by the analyzer controller 50, an error can be prevented from occurring in the analysis result of the sample.

  In addition, this invention is not limited to the above-mentioned Example, Implementation in a various aspect is possible within the range of a summary. For example, in the above embodiment, the second cleaning nozzle 202 is used as a steam cleaning line for steam cleaning, and the subsequent third cleaning nozzle 203 to sixth cleaning nozzle 206 perform alkali cleaning, acidic cleaning, and pure water cleaning. However, it is not necessarily limited to performing the cleaning in this order.

  That is, as schematically shown in FIG. 9 the nozzles provided in the cleaning unit 20, the high-concentration mixed solution remaining in the reaction cell 10 is discharged by the first cleaning nozzle 201, but the second The cleaning nozzle 202 is used as an alkali cleaning line to perform alkaline cleaning with an alkaline detergent, the third cleaning nozzle 203 is used as an acidic cleaning line to perform acidic cleaning, and the next fourth cleaning nozzle 204 is used as a steam cleaning line to perform steam cleaning. You may do it. Thereafter, the fifth cleaning nozzle 205 performs cleaning with pure water as a pure water cleaning line. In this case, since the fourth cleaning nozzle 204 performs steam cleaning, the sixth cleaning nozzle 206 is It can be abolished and the pure water cleaning can be completed only once. In this way, pure water for cleaning can be saved.

DESCRIPTION OF SYMBOLS 10 Reaction cell 30 Steam generator 31 Sealed container 32 Heater 33 Temperature sensor 34 Water supply pipe 35 Steam discharge pipe 40 Washing water tank 41 Supply control valve 42 Pump 43 Discharge control valve 50 Analyzer control part 60 Nozzle drive part 70 Temperature sensor 200a Cover 200b Elastic member 202 Second cleaning nozzle (steam cleaning line)

Claims (4)

In an automatic analyzer that analyzes the components of the sample by reacting a mixture of the sample and reagent dispensed in a reaction cell,
Steam generating means for generating steam;
A nozzle for discharging the steam generated by the steam generating means ;
Nozzle driving means for raising or lowering the nozzle and taking the nozzle into and out of the reaction cell;
When the nozzle is lowered by a predetermined length by the nozzle driving means, a cover that closes the inside of the reaction cell by contacting the reaction cell;
Comprising
The nozzle is the case where the cover by a nozzle drive means further lowered after contact with the reaction cell, and slide relative to the cover, an automatic analyzer Ru is maintaining the substantially closed state of the reaction cell. 2. The automatic analyzer according to claim 1, further comprising an expansion / contraction member provided at an upper portion of the cover portion and extending until the nozzle is lowered by the predetermined length and contracting when the nozzle is further lowered . The automatic analyzer according to claim 1 , wherein the nozzle discharges vapor when the inside of the reaction cell is in the substantially closed state . A temperature sensor for detecting the temperature of the reaction cell in which the steam is discharged by said nozzle,
Means for controlling the operation of the automatic analyzer so that the reaction cell is not subjected to the next analysis when the temperature of the reaction cell detected by the temperature sensor exceeds a predetermined temperature;
The more automated analyzer according to any one of claims 1 to 3 you Bei immediately.

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