JP5371424B2 - Ｒｎａ干渉のためのオリゴヌクレオチドおよびその生物学的適用 - Google Patents

Ｒｎａ干渉のためのオリゴヌクレオチドおよびその生物学的適用 Download PDF

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JP5371424B2
JP5371424B2 JP2008514036A JP2008514036A JP5371424B2 JP 5371424 B2 JP5371424 B2 JP 5371424B2 JP 2008514036 A JP2008514036 A JP 2008514036A JP 2008514036 A JP2008514036 A JP 2008514036A JP 5371424 B2 JP5371424 B2 JP 5371424B2
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nucleic acid
oligonucleotide
oligomerized
sequence
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JP2008541745A5 (enMedlin
JP2008541745A (ja
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ジャン ポール ベア
ベルマン アンヌ ロール ボルカト
パトリック エルバッハー
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ポリプラス トランスフェクション エスアー
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/50—Physical structure
    • C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers
    • C—CHEMISTRY; METALLURGY
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    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/51—Methods for regulating/modulating their activity modulating the chemical stability, e.g. nuclease-resistance
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    • C12N2320/00—Applications; Uses
    • C12N2320/50—Methods for regulating/modulating their activity
    • C12N2320/52—Methods for regulating/modulating their activity modulating the physical stability, e.g. GC-content

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
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  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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  • Plant Pathology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
JP2008514036A 2005-06-01 2006-06-01 Ｒｎａ干渉のためのオリゴヌクレオチドおよびその生物学的適用 Expired - Fee Related JP5371424B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US68601005P 2005-06-01 2005-06-01
US60/686,010 2005-06-01
PCT/EP2006/006340 WO2006128739A1 (en) 2005-06-01 2006-06-01 Oligonucleotides for rna interference and biological applications thereof

Publications (3)

Publication Number Publication Date
JP2008541745A JP2008541745A (ja) 2008-11-27
JP2008541745A5 JP2008541745A5 (enMedlin) 2009-07-09
JP5371424B2 true JP5371424B2 (ja) 2013-12-18

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JP2008514036A Expired - Fee Related JP5371424B2 (ja) 2005-06-01 2006-06-01 Ｒｎａ干渉のためのオリゴヌクレオチドおよびその生物学的適用

Country Status (6)

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US (2) US8802640B2 (enMedlin)
EP (1) EP1888749B1 (enMedlin)
JP (1) JP5371424B2 (enMedlin)
CN (1) CN101213300B (enMedlin)
DK (1) DK1888749T3 (enMedlin)
WO (1) WO2006128739A1 (enMedlin)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5371424B2 (ja) 2005-06-01 2013-12-18 ポリプラス トランスフェクション エスアー Ｒｎａ干渉のためのオリゴヌクレオチドおよびその生物学的適用
SI2056845T1 (en) * 2006-08-08 2018-02-28 Rheinische Friedrich-Wilhelms-Universitaet Bonn STRUCTURE AND USE 5 'PHOSPHATE OF OLIGONUCLEOTES
CA2682135A1 (en) 2007-04-17 2008-10-30 Baxter International Inc. Nucleic acid microparticles for pulmonary delivery
JP5689413B2 (ja) 2008-05-21 2015-03-25 ライニッシュ フリードリッヒ−ウィルヘルムズ−ユニバーシタット ボン 平滑末端を有する５’三リン酸オリゴヌクレオチドおよびその使用
EP2508530A1 (en) 2011-03-28 2012-10-10 Rheinische Friedrich-Wilhelms-Universität Bonn Purification of triphosphorylated oligonucleotides using capture tags
EP2712870A1 (en) 2012-09-27 2014-04-02 Rheinische Friedrich-Wilhelms-Universität Bonn Novel RIG-I ligands and methods for producing them
DK3119887T3 (da) * 2014-03-20 2019-05-20 Oommen Varghese Forbedrede korte interfererende ribonukleinsyremolekyler
WO2016110691A1 (en) * 2015-01-06 2016-07-14 The University Court Of The University Of Aberdeen Enhanced rnai mediated gene regulation

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6506559B1 (en) * 1997-12-23 2003-01-14 Carnegie Institute Of Washington Genetic inhibition by double-stranded RNA
US20030212022A1 (en) * 2001-03-23 2003-11-13 Jean-Marie Vogel Compositions and methods for gene therapy
IL151928A0 (en) 2000-03-30 2003-04-10 Whitehead Biomedical Inst Rna sequence-specific mediators of rna interference
EP1873259B1 (en) 2000-12-01 2012-01-25 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. RNA interference mediated by 21 and 22nt RNAs
EP1386004A4 (en) * 2001-04-05 2005-02-16 Ribozyme Pharm Inc MODULATION OF GENE EXPRESSION ASSOCIATED WITH INFLAMMATORY PROLIFERATION AND GROWTH OF NEURITIES BY METHODS INVOLVING NUCLEIC ACID
JP5371424B2 (ja) 2005-06-01 2013-12-18 ポリプラス トランスフェクション エスアー Ｒｎａ干渉のためのオリゴヌクレオチドおよびその生物学的適用

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Publication number Publication date
CN101213300A (zh) 2008-07-02
US20080153772A1 (en) 2008-06-26
US8802640B2 (en) 2014-08-12
EP1888749A1 (en) 2008-02-20
EP1888749B1 (en) 2014-10-15
US9243248B2 (en) 2016-01-26
JP2008541745A (ja) 2008-11-27
DK1888749T3 (en) 2015-01-05
US20140343125A1 (en) 2014-11-20
CN101213300B (zh) 2013-01-23
WO2006128739A1 (en) 2006-12-07

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