JP5335857B2 - Sheet for introducing active ingredient into subject and method for producing the same - Google Patents

Description

  The present invention relates to an iontophoresis device capable of efficiently introducing an active ingredient into a living body, and more specifically, utilizing a surface potential difference between two different parts of a living body surface, and an electrolyte and an electrode on the body surface. To provide an iontophoresis device that is low in cost, easy to use, safe, highly effective in introducing active ingredients, compact, portable, and disposable .

The following patents are already known for iontophoresis devices.
An iontophoresis device that delivers the activator of the second reservoir when current flows in a different direction (see Patent Document 1).
A portable transdermal drug administration applicator (see Patent Document 2).
A drug supply device by an iontophoresis method and a method for using the same (see Patent Document 3).
An electronic skin beautifier and an ion introduction method using the electronic skin beautifier (see Patent Document 4).
An iontophoresis device including a two-core cable that electrically connects the main body and the holding tool (see Patent Document 5).
An iontophoresis machine in which the electrode portion is less likely to be charged by being biased to a negative potential or a positive potential (see Patent Document 6).
A combination of an iontophoresis device and an ultrasonic facial device (see Patent Document 7).
Since these devices use a dry battery or the like for the power source even if they are portable, they are heavy, have a complicated internal structure, are expensive, and are complicated to use.
In addition, since the voltage is high and the amount of current is large, burns and rashes may occur, which causes safety problems.

  These iontophoresis machines are at least 100 g in weight, have a capacity of 100 CC or more, are large and heavy, and are inexpensive at a cost of 1000 yen or more. In addition, the method of use is complicated and difficult to understand, and since a high current is used, there is a risk of burns, and skin irritation occurs frequently, which is dangerous. In particular, the high cost of the iontophoresis device is inconvenient for daily use such as beauty.

JP-T 9-503136 Japanese National Patent Publication No. 8-505799 Special Table 2000-510012 JP 2001-259045 A JP 2003-19214 A JP 2004-202022 A JP-A-2005-245521

  Therefore, the inventors of the present invention are to provide an iontophoresis device that is extremely inexpensive, easy to use, safe, highly effective in introducing active ingredients, small and light, portable, and disposable. is there.

  When a simple substance in the solution and ions of another element exist, if a redox reaction occurs between them, the simple substance is oxidized and ionized, while the other is reduced and precipitated as a simple substance. At this time, “the oxidized element has a higher ionization tendency than the reduced element”. Which is oxidized and which is reduced depends on the magnitude of the oxidation-reduction potential, so that the elements arranged in the order of this potential are in the order of ionization tendency.

The smaller the ionization tendency, the easier the ions are reduced and precipitate as metal.
Further, even a metal having a large ionization tendency can be obtained by molten salt electrolysis.
Regarding the ionization tendency, cesium (Cs) is the largest and iridium (Ir) .tantalum (Ta) is the smallest, but the order of the ionization tendency of the general-purpose substances is as follows. Lithium (Li)> Rubidium (Rb)> Potassium (K)> Barium (Ba)> Strontium (Sr)> Calcium (Ca)> Sodium (Na)> Magnesium (Mg)> Aluminum (Al)> Manganese (Mn)> Zinc (Zn)> Chromium (Cr)> Iron (Fe)> Cadmium (Cd)> Cobalt (Co)> Nickel (Ni)> Tin (Sn)> Lead (Pb)> (Hydrogen (H2))> Antimony (Sb )> Bismuth (Bi)> copper (Cu)> mercury (Hg)> silver (Ag)> palladium (Pd)> platinum (Pt)> gold (Au)

  When two different types of metals and an electrolytic solution are combined, a potential difference is generated between the two types of metal electrodes. At this time, the metal with the larger ionization tendency becomes the negative electrode, and the smaller one becomes the positive electrode. In addition, the greater the difference in ionization tendency between the two types of metals, the greater the electromotive force between the electrodes. For example, when copper and a zinc plate are immersed in sweat, zinc becomes a negative electrode and copper becomes a positive electrode (the electrolyte is sweat).

Since the biggest problem of the iontophoresis device is the volume, weight, and cost occupied by the power supply device, the present inventors considered whether the current that is naturally generated in the living body can be used for the iontophoresis device.
Therefore, as a result of measuring the potential difference instantaneously generated in each part of the human body with a voltmeter at two different points of the human body, it is found that an average voltage difference of 90 mV for the DC voltage and 65 mV for the maximum AC voltage is generated. I found it. Furthermore, when the voltage was measured between the living body surface and the earth (underground), the maximum DC voltage difference -901 mV to +912 mV, and the maximum AC voltage 1.223v, which are higher than the voltage difference measured at two locations in the human body. A voltage was observed. These voltages are due to physiological biochemical reactions in the body, due to the interaction of organic acids and electrolyte components in body fluids such as sweat and electrode metal, and due to static electricity on the body surface and clothes. It was estimated to be static electricity stored in weather conditions and buildings.

  The maximum voltage of 900 mV between the human body and the ground is high enough for ion introduction, but these voltages not only change with time but also positive and negative are reversed due to climate change and ground current, etc., and the voltage is not stable. . In addition, since the amount of current is very small, there is a problem that it is difficult to generate an electromotive force that sufficiently exhibits the effect of ion introduction. Therefore, the present inventors utilize the potential difference between the electrodes by installing a circuit composed of a power storage device such as a relay and a capacitor, and a rectifier such as a diode in order to secure power sufficient to maintain ion introduction for a long time. Thus, the present invention was completed by devising a device that increases the voltage while storing the voltage in G and maintaining one of the electrodes negatively or positively.

  Furthermore, the electromotive force was secured by the oxidation-reduction reaction of the ion electrode and sweat, which is a biological component, by making the electrode to be brought into contact with the human body from a combination of metals having different ionization tendencies. For example, since the component of human sweat is an electrolyte, a stable voltage of about 400 to 1000 mV is generated if the skin is not extremely dry by a combination of a copper and zinc electrode or a copper and aluminum electrode. Since copper becomes positive and zinc or aluminum electrode becomes negative, negatively charged molecules such as ascorbic acid need to be introduced from the aluminum electrode side. If the skin is dry, apply a small amount of water to the skin to energize it. These waters can also be replenished by applying cosmetic ingredients containing active ingredients to the skin.

  In addition to copper, gold, silver, platinum, etc., which are safe for the skin and important as micronutrients, can be selected as the material for the positive electrode. The negative electrode may be calcium, iron, nickel, or an alloy containing potassium, sodium, magnesium and the like in addition to zinc and aluminum. Furthermore, a power storage device such as a capacitor can be incorporated in the circuit in order to effectively use the weak power. As a matter of course, a stable power supply necessary for ion introduction can be supplemented by incorporating a power source such as a photovoltaic power generation device, a temperature difference power generation device, or a micro dry battery.

That is, the present invention comprises the following claims.
[Claim 1]
Electronically record and capture an image of a subject, electronically process the image to identify one or more locations with a specific tone or absorption wavelength, and map one or more to the mapped position A method for producing a sheet for introducing a single-layer or multiple-layer active ingredient into a subject, wherein a solution containing a plurality of active ingredients is accurately printed on a mask sheet in μm units using a printing apparatus.
[Claim 2]
Electronically record and capture an image of a subject, electronically process the image to identify one or more locations with a specific tone or absorption wavelength, and map one or more to the mapped position As a single-layer or multi-layer sheet obtained by printing a solution containing a plurality of components on a mask sheet accurately in units of μm using a printing apparatus, the components are different and the printing positions are the same. A plurality of sheets are produced, and a plurality of the sheets are accurately stacked so that the positions of the prints coincide with each other, thereby causing a chemical reaction with the components of the plurality of sheets, and generating or A method for producing a sheet for introducing an active ingredient into a subject, wherein the changed active ingredient is accurately arranged on a mask sheet in units of μm.
[Claim 3]
Electronically record and capture an image of a subject, electronically process the image to identify one or more locations with a specific tone or absorption wavelength, and map one or more to the mapped position A method for producing a sheet for introducing a single-layer or multiple-layer active ingredient into a subject, wherein a liquid solvent containing a plurality of conductive substances is accurately printed on a mask sheet in μm units using a printing apparatus.
[Claim 4]
A single or multi-layer sheet obtained by accurately printing a solution containing a single component or a plurality of components on a mask sheet in units of μm, and using a plurality of sheets having different components and the same printing position. The above-described sheets are accurately stacked so that the printing positions coincide with each other, thereby causing a chemical reaction with the components of the plurality of sheets, and an active ingredient generated or changed depending on the result of the reaction, in μm units. A sheet for introducing the active ingredient into the subject accurately placed on the mask sheet.

The present invention also relates to the following (1) to (14).
(1) A voltage difference is generated between the electrodes CD due to a natural voltage difference between different parts of the body surface of the organism, whereby an active ingredient is selected from one of C, E, and D, or a plurality selected from them, on the body surface of the organism. An iontophoresis device that introduces ions. (A represents a body surface of a human body or a living organism and has a conductive property because it is filled with a body fluid of an electrolyte. F is a target site into which an active ingredient existing on the surface of the organism is to be introduced. The solvent which can ionize the component which comprises the electrode of C, or the solvent containing the effective component which can be electrophoresed effective for the solvent and the biological tissue F, and the support | carrier or molding which hold | maintains the solvent are represented. Represents electrodes placed at different locations on the body surface, B represents a conductive wire connecting the two electrodes, Electrode D is in contact with the body surface, Electrode C contained body surface F and active ingredients It is in contact via the electrolyte solution E. A slight potential difference is instantaneously generated between D and C due to physiological activities of the living body, and the electrodes C and D may be made of the same material. Power storage devices such as relays and capacitors, A circuit comprising a rectifying device such as a diode, it is also possible to charge the electrode C increases the power storage and voltage weak current not only starts and stops the flow of current to the negative or positive electrode.)
[Figure 1]
(2) Due to a natural voltage difference between the body surface of the living organism and the earth, a voltage difference is generated between the electrode C and the earth D, so that the active ingredient is selected from one of C and E or a plurality selected from them. An iontophoresis device that introduces ions into (A represents a body surface of a human body or a living organism and is electrically conductive because it is filled with an electrolyte body fluid. E is a solvent capable of ionizing components constituting the electrode of C or its solvent and biological tissue. F represents a solvent containing an electrophoretic active ingredient effective for F, and a carrier or molded product that holds the solvent, F is a target site into which an active ingredient existing on the surface of the organism is to be introduced, and C is a body surface. B represents a conductive wire, D represents a final contact with the earth such as the ground surface, etc. Electrode C passes through body surface F and electrolyte solution E containing active ingredients. G is a circuit composed of a conductive wire or a power storage device such as a relay or a capacitor, or a rectifier device such as a diode, which not only stops and flows the current but also stores a weak current and stores the voltage at a high electrode. C minus or plus It can also be charged.)
[Figure 2]
(3) Electricity is generated using the difference in ionization tendency between two different electrodes from the electrolyte solution that exists naturally or artificially on the body surface of the organism, causing a voltage difference between electrode C and electrode D. An iontophoresis device that introduces an active ingredient from one of C, E, D, and F or a plurality selected from them from the body surface. (A represents the body surface of a human body or a living body. C and D represent metal electrodes selected from materials having different ionization tendency installed at different locations on the body surface. E and F represent C or D electrodes. Represents a solvent capable of ionizing the components constituting the solvent, or a solvent containing the solvent and an effective component capable of electrophoresis that is effective for the living tissue G, and a carrier or a molded product that holds the solvent. Natural electrolyte solution may be used.)
[Figure 3]
(4) Electricity is generated by utilizing a difference in ionization tendency between two electrodes different from an electrolyte solution that is naturally or artificially present on the body surface of a living organism, and a voltage difference is generated between the electrodes CD. , D and F, or an iontophoresis device for introducing an active ingredient from the body surface from a plurality selected from them. (E and F are solvents that can ionize components constituting the C or D electrode, or a solvent containing the solvent and an effective component that can be electrophoresed for the biological tissue G, and a carrier or molding that holds the solvent. F may be a natural electrolyte solution present on the body surface, and G is a circuit composed of a conductive wire or a power storage device such as a relay or a capacitor, or a rectifier device such as a diode, which stops or flows current. In addition to storing a weak current, the voltage can be increased and the electrode C can be negatively or positively charged, so that the ionized active component in E is more easily transferred to A, improving efficiency and safety. The iontophoresis device of (1) in FIG.
[Fig. 4]
(5) The composition for an iontophoresis device according to (1) to (4), wherein the electrodes C and D are composed of one or a mixture of two or more selected from components that can be ionized and eluted by E and F in contact therewith. .
(6) The composition for an iontophoresis device according to (5), wherein the ionizable and eluting component is selected from the following atoms or components containing atoms.
C (carbon), Sn (tin), Pb (lead), Cu (copper), Ag (silver), Pt (platinum), Au (gold), K (potassium), Ca (calcium), Na (sodium), Mg (magnesium), Al (aluminum), Zn (zinc), Fe (iron), Ni (nickel)
(7) One or two types of electrode metal selected from either of the following groups A or B, and a gold poison of the D electrode selected from a group having a different ionization tendency from the metal of the C electrode The composition for iontophoresis devices of (1) to (6) comprising the above mixture.
Group A) K, Ca, Na, Mg, Al, Zn, Fe, Ni
B group) Sn, Cu, Ag, Pt, Au
(8) E or F or both are exchangeable carriers, solvents, and active ingredients that exert physiological effects on biological tissues and cells, and these active ingredients are selected from simple substances or two kinds selected from substances that can be electrophoresed The iontophoresis device of (1) to (4) selected from the above composites.
(9) Electronically record and capture an object image, electronically process the image to identify one or a plurality of locations having a specific color tone or absorption wavelength, and map the position. A sheet for introducing a single-layer or multiple-layer active ingredient into a subject, in which a solution containing one or a plurality of active ingredients is printed on a mask sheet accurately in units of μm using a printing apparatus.
(10) A plurality of different components are printed on a plurality of sheets of (9), and finally a chemical reaction is caused by accurately stacking those sheets, and the active ingredient generated or changed by the result of the reaction is expressed in μm. A sheet that accurately introduces the active ingredients on the mask sheet to the subject.
(11) Electronically record and capture an object image, electronically process the image to identify one or a plurality of locations having a specific color tone or absorption wavelength, and map the position. A method for producing a sheet for introducing a single-layer or multi-layer active ingredient into a subject, wherein a solution containing one or more active ingredients is printed on a mask sheet accurately in units of μm using a printing apparatus.
(12) The active ingredient introduction sheet according to (9) to (10), which is printed by including a conductive liquid solvent and is a single layer or multiple layers for ion introduction.
(13) A method for producing a sheet for introducing an active ingredient according to (9) to (10), which is a single-layer or multi-layer for ion introduction printed containing a conductive liquid solvent.
(14) The iontophoresis device according to any one of (1) to (4), wherein the iontophoresis device is a single-layer or multilayer (12) iontophoresis sheet printed containing a conductive liquid solvent.

In the present invention (1) to (7), two or more electrodes can be connected as shown in the following figure, and the area of the electrodes can be increased. The electromotive force can be increased by expanding the electrode area, and the amount of active ingredient introduced per unit area can be increased by increasing the flow rate of electrons per unit area of the electrode by reducing the electrode on the side where the active ingredient is introduced. Can be increased.
[Figure 5]

Iontophoresis device of the present invention Iontophoresis device of the present invention Iontophoresis device of the present invention Iontophoresis device of the present invention Iontophoresis device of the present invention having multiple electrodes Cap type iontophoresis device Example of using a cap type iontophoresis device Iontophoretic patch Iontophoretic patch Iontophoretic patch Iontophoresis mask sheet

The Δ _γ G ^o of a given total reaction is equal to the difference in Δ _γ G ^o of the reduction half reaction that constitutes it. Thus, the value of E ^{o for} the total reaction combining the two reduction half reactions is equal to the difference in E ^o for those half reactions. For example, the electromotive force of the iontophoresis device of the present invention using copper and zinc electrodes is obtained as follows. Each reduction half reaction formula is
(Chemical formula 1)
(1) ... Cu ²⁺ (aq) + 2e ⁻ → Cu (s) E ^o = + 0.34V
(Chemical formula 2)
(2) ... Zn ²⁺ (aq) + 2e ⁻ → Zn (s) E ^o = −0.76 V
It is. Taking this difference,
(Chemical formula 3)
(1-2) ... Cu ²⁺ (aq) + Zn (s) → Cu (s) + Zn ²⁺ (aq)
E ^o = + 1.1V

As the metal material of the electrode used in the iontophoresis device of the present invention (1), a simple substance selected from the following metals or a composite composition of two or more types is suitable. preferable. Carbon, fullerene, graphite, potassium (K), barium (Ba), strontium (Sr), calcium (Ca), sodium (Na), magnesium (Mg), aluminum (Al), manganese (Mn), zinc (Zn) , Chromium (Cr), iron (Fe), cadmium (Cd), cobalt (Co), nickel (Ni), tin (Sn), antimony (Sb), bismuth (Bi), copper (Cu), silver (Ag) , Palladium (Pd), platinum (Pt), gold (Au). In particular, a metal selected from K, Ca, Na, Mg, Al, Zn, Fe, Ni, Sn, Cu, Ag, Pt, and Au is desirable.
As the metal material of the electrode used in the iontophoresis device of the present invention (2), a simple substance selected from the following metals or a composite composition of two or more kinds is suitable, and different metals having different ionization tendencies even with different electrodes or Metal composites with different compositions are preferred. Carbon, fullerene, graphite, potassium (K), barium (Ba), strontium (Sr), calcium (Ca), sodium (Na), magnesium (Mg), aluminum (Al), manganese (Mn), zinc (Zn) , Chromium (Cr), iron (Fe), cadmium (Cd), cobalt (Co), nickel (Ni), tin (Sn), antimony (Sb), bismuth (Bi), copper (Cu), silver (Ag) , Palladium (Pd), platinum (Pt), gold (Au). Particularly considering safety and nutritional effects on cells, different combinations of metals selected from K, Ca, Na, Mg, Al, Zn, Fe, Ni, Sn, Cu, Ag, Pt, and Au are desirable.

Among the above metals, the metal of the electrode is selected from one of the following groups A or B because of its superiority as a nutrient as a safety and trace metal mineral, and the gold poison of the other electrode is different from the former It is desirable that the metal is composed of a single substance or a mixture of two or more selected from these metals.
Group A) K, Ca, Na, Mg, Al, Zn, Fe, Ni
B group) Sn, Cu, Ag, Pt, Au
These metals are metal plates or metal molded products, metal films obtained by rolling metal, metal porous molded products, metal composites, metal wires, and metal wires that are knitted into a cloth shape in the iontophoresis device of the present invention. Or metal powder or metal vapor-deposited molded body, metal powder dispersed in resin, metallic paint dispersed in paint, metal plating coated on an insulating molded body such as plastic it can. Further, the electrode of the present invention includes a cold-rolled steel sheet, a hot-dip galvanized steel sheet, an electrogalvanized steel sheet, a molten 5% Al-Zn alloy-plated steel sheet, a molten 55% Al-Zn alloy-plated steel sheet, and a molten Zn-Al-Mg alloy plating. Various metal plates such as a steel plate, a hot-dip aluminized steel plate, a stainless steel plate, an aluminum plate, an aluminum alloy plate, a copper plate, and a copper alloy plate can be used. Moreover, in order to improve coating film adhesion and corrosion resistance, pre-coating treatments such as degreasing, surface conditioning, chromate treatment, chromium-free treatment, and phosphate treatment can be applied to the electrode. For metallic paints, one or more resin paints selected from polyester, acrylic, silicone polyester, and urethane can be used, and metal flakes such as aluminum are added as metallic pigments. Aluminum flakes having an average particle diameter (major axis) of 10 to 20 μm and an aspect ratio (ratio of major axis / thickness) of 50 to 100 can be used. You may mix | blend aluminum flakes in the ratio of 0.5-20 mass parts with respect to 100 mass parts of coating resin. If the metal flakes are less than 0.5 parts by mass, the electroconductivity is poor. Conversely, if the metal flakes exceed 20 parts by mass, the viscosity of the paint becomes high and the paintability is poor, and the coating film tends to have poor appearance.
Further, a hindered amine light stabilizer can be added to improve weather resistance. However, liquid disperse seeds (TINUVIN 292, TINUVIN 123, ADK STAB LA-62, Adekastab LA-67) is preferred. Each of the hindered amine light stabilizers is an amine compound that is basified in a moisture-containing atmosphere, and one or more of them are blended at a ratio of 0.1 to 2 parts by mass with respect to 100 parts by mass of the coating resin. You can also If the amount is less than 0.1 parts by mass, the effect of improving the weather resistance is poor. However, excessive blending exceeding 2 parts by mass causes bleeding on the surface of the coating film, and it cannot be expected to improve the performance corresponding to the amount of addition. May cause a rise. As a dehydrating agent for removing water from paints in which hindered amine light stabilizers and aluminum flakes coexist, one or more of trialkyl orthoformate, trialkyl orthoacetate, trialkyl orthoborate is preferably 1 to 20 masses. It can also be added at a ratio of parts. In addition to the metallic paint, inorganic pigments such as titanium oxide and iron oxide, and organic pigments such as phthalocyanine and anthocyan may be blended as color pigments. Extender pigments such as barium sulfate and talc can also be added. Addition of aggregates such as glass beads, glass flakes, acrylic beads, PAN beads and nylon beads, and matting agents such as silica and fine urea resin to add design and wrinkle resistance. You may do it.
As the metallic paint that can be used in the present invention, an acrylic urethane-based acrylic polyol, a cellulose-based resin paint, a polyisocyanate-based curing agent, and the like, in which an aluminum pigment is dispersed, can be used as a specific example. Mr. Color, Mr. Metal color, Mr. Spray silver (silver), gold (gold), metallic red, talic blue, metallic green, metal black, copper (copper), super silver, gun chrome, paint, Taiei Sangyo Co., Ltd., Acrytop # 500, poly wrap G41, polywrap GX81-X, polywrap No. 1. Polywrap K101, Acryshine # 1000, Thin Track Series, Metal Star TS-260, Silver Metal Star TS-260, Silver Hyper Metal Star SP8 Silver, Metal Star BC-2000 Silver, etc., made by Suzuka Fine Co., Ltd., acrylic resin paint . Rafton Acrienamel. Acrylic resin metallic paint. Rafton metallic. Elastic acrylic resin paint. Rafton elastic enamel. Acrylic resin clear. Rafton Clear. Although there is a Rafton metallic paint, it is not particularly limited.
Further, as the metal electrode material of the present invention, water-soluble or solvent-based conductive silver paint, conductive graphite paint, conductive nickel paint, conductive copper paint, conductive silver-plated copper paint, conductive silver paint, conductive silver A plated copper paint or the like can be used. Specific examples include ELECTRODAG550, JEF-603, JEF-606, nickel-containing paints, and ELECTRODAG SP-029, which are nickel-containing paints, among conductive paint products manufactured by Moritex Corporation.

  The substance that can be ion-introduced using the iontophoresis device of the present invention may be any substance that can be dissolved as an ion in an electrolytic solution that can sufficiently ensure safety even when it comes in contact with a living body. Even if it can disperse | distribute in a solvent as an emulsified particle by the combination with a cation or an anionic surfactant, it will not specifically limit.

  Examples of substances that can be ionized using the iontophoresis device of the present invention include salts of vitamin derivatives. As specific examples, for example, sodium L-ascorbate, magnesium aluminum L-ascorbate, magnesium potassium L-ascorbate, magnesium calcium L-ascorbate, magnesium germanium ascorbate, magnesium zinc ascorbate, L- Ascorbic acid-2-sodium magnesium sulfate, L-ascorbic acid-2-magnesium sulfate aluminum, L-ascorbic acid-2-magnesium sulfate potassium, L-ascorbic acid-2-magnesium sulfate calcium, L-ascorbic acid-2-sulfate Magnesium germanium, L-ascorbic acid-2-glucoside magnesium sodium, L-ascorbic acid-2-glucoside magnesium aluminum, L-ascorbine 2-glucoside magnesium potassium, L- ascorbic acid 2-glucoside magnesium calcium, L- ascorbic acid 2-glucoside magnesium germanate Niu, may be a constant.

  Furthermore, examples of those that can be dispersed in a solvent as emulsified particles in combination with a cationic or anionic surfactant include endothelin antagonists, glutathione and derivatives thereof, salts thereof, cysteine and derivatives thereof, salts thereof, resorcin and derivatives thereof Derivatives and salts thereof, hydroquinone and derivatives thereof and salts thereof, glabrizine, glabrene, liquiritin, isoliquiritin and licorice extract containing these, placenta extract, carotenoids and animal and plant extracts containing these, neoagarobiose , Agarose oligosaccharides, asparagus extract, Ibukitorano extract, pea extract, Ages extract, Ogon extract, Ononis extract, seaweed extract, raspberry extract, cucumber extract, caquette extract , Scallop extract, plant oil containing linoleic acid, saicin extract, hawthorn extract, sampens extract, shirayuri extract, peonies extract, sempukuka extract, sohakuhi extract, soybean extract, tea extract, toki Extract, molasses extract, beechlen extract, beech extract, grape seed extract, flow demanita extract, hop extract, squid extract, mokka extract, yukinoshita extract, yokuinin extract and rakan fruit extract, Astaxanthin, glabrizine, glabrene, liquiritin, isoliquiritin and licorice extract, placenta extract, neo agarobiose, agarose oligosaccharide, ibukitorano extract, seaweed extract, caquette extract, gokahi extract, sun penz extract Product, Sempukuka extract, Tea, black tea, tea extracts such as oolong tea, molasses extract, Byakuren extract, grape seed extract, Maikaika extract include currently extract and Coix extract. The above seaweed extracts include kombu, macombu, wakame, hijiki, hibamata, umiuchiwa, matsumo, mozuku, ishige, havanori, kumodomo, fukuronori, iwahige, kagomenori, aname, sujime, trorokonbu, kajime, tsuraarazo, chigae Brown algae such as trumpet, hondawala, monarch kelp, giant kelp, and Japanese primrose, larva, onyxa, duckweed, crested beetle, giraffe, horned beetle, tochiyaka, sugi nori, shinkinori, kainori, usbanori, oxenobi, ashnosori Red algae such as centipede, pine, pine, funeral, ibranori, ogonori, spider, duls, igis, egonori, konohanori, himegoke, and chlorella, aonori, donna Ella, chloro Lactococcus, Ulva pertusa, Kawanori, Marimo, Cladophora, Acetabularia acetabulum, Futojuzumo, Tamajuzumo, Hitoegusa, there is Spirogyra.

  Furthermore, as examples of components that are effective for the iontophoresis device of the present invention and can be dispersed in a solvent as an emulsified particle in combination with a cation or an anionic surfactant, the following cell activator, active oxygen scavenger, humectant, There are skin astringents, vitamins and amino acids and their derivatives and salts.

For example, cell activators include deoxyribonucleic acid and salts thereof, adenylic acid derivatives such as adenosine triphosphate and adenosine monophosphate and salts thereof, ribonucleic acid and salts thereof, cyclic AMP, cyclic GMP, flavin adenine nucleotides Nucleic acid-related substances such as guanine, adenine, cytosine, thymine, xanthine and their derivatives caffeine, theoferrin and their salts, calves blood extract, serum deproteinized extract, spleen extract, avian eggs, etc. Ingredients, chicken crown extract, shell extract, shell extract, royal jelly, silk protein and its degradation product or derivatives thereof, hemoglobin or degradation product thereof, lactoferrin or degradation product thereof, mollusc extract such as squid, fish meat extraction Things, mammals, birds, shellfish, insects, fish, molluscs, shellfish Extracts from animal etc., yeast extract, lactic bacteria extract, extracts derived from microorganisms selected from fermentation metabolites of bifidobacteria extract, and the like.
Further, as cell activators, retinol and its derivatives (retinol palmitate, retinol acetate, etc.), retinal and its derivatives, vitamin A such as carotenoids such as dehydroretinal, tretinoin, carotene, thiamines (thiamine hydrochloride, thiamine sulfate) ), Riboflavins (riboflavin, riboflavin acetate, etc.), pyridoxines (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), flavin adenine nucleotides, cyanocobalamin, folic acids, nicotinic acids (nicotinamide, benzyl nicotinate, etc.), cholines Such as vitamin B, apricot extract, ginkgo biloba extract, ginseng extract, barley extract, orange extract, cucumber extract, kiwi extract, shiitake extract, cedar extract, assembly extract, sweet potato Extracts from plants such as extract, pepper extract, garlic extract, carrot extract, bukkuri extract, peach extract, lettuce extract, lemon extract, ganoderma extract, rosemary extract, hinokitiol, cephalanthin , Α- and γ-linolenic acid, eicosapentaenoic acid and derivatives thereof, estradiol and derivatives thereof and salts thereof, organic acids such as glycolic acid, succinic acid, lactic acid and salicylic acid and derivatives thereof and salts thereof Can be mentioned. One or two or more cell activators listed above can be appropriately selected and blended.

  As active oxygen scavengers, superoxide dismutase, mannitol, bilirubin, cholesterol, tryptophan, histidine, quercetin, fullerene, fullerene hydroxide, quercitrin, catechin, catechin derivatives, rutin, rutin derivatives, taurine, thiotaurine, eggshell membrane extract , Gallic acid, gallic acid derivatives, yeast extract, ganoderma lucidum extract, yashajitsu extract, genus shochu extract, buttonpi extract, melissa extract, parsley extract and dicoppi extract, retinol and its derivatives (retinol palmitate, Retinol acetate, etc.), retinal and its derivatives, vitamin A such as dehydroretinal; thiamines (thiamine hydrochloride, thiamine sulfate, etc.), riboflavins (riboflavin, riboflavin acetate, etc.), pyrido Vitamin Bs such as syns (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), flavin adenine nucleotides, cyanocobalamin, folic acids, nicotinic acids (nicotinamide, benzyl nicotinate, etc.), cholines, etc .; ergocalciferol, cholecalci Vitamin Ds such as ferrol and dihydroxystannal; tocopherol and derivatives thereof (dl-α (β, γ) -tocopherol, dl-α-tocopherol acetate, nicotinic acid-dl-α-tocopherol, linoleic acid-dl-α- Tocopherol, dl-α-tocopherol succinate, etc.), vitamin E such as ubiquinones; dibutylhydroxytoluene and butylhydroxyanisole.

  Examples of moisturizing agents include alkaline simple hot spring water, deep layer water, hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate, or salts thereof, proteins such as collagen, elastin and keratin, or their Derivatives and salts thereof, phospholipids derived from soybeans and eggs, glycolipids, ceramides, mucins, honey, erythritol, maltose, maltitol, xylitol, xylose, pentaerythritol, fructose, dextrin and its derivatives, mannitol, sorbitol, inositol, Sugars such as trehalose and glucose, urea, asparagine, aspartic acid, alanine, arginine, isoleucine, ortinin, glutamine, glycine, glutamic acid and derivatives thereof, and their Amino acids such as cysteine, cystine, citrulline, threonine, serine, tyrosine, tryptophan, theanine, valine, histidine, hydroxylysine, hydroxyproline, pyrrolidone carboxylic acid and salts thereof, proline, phenylalanine, methionine, lysine and the like or their derivatives And the like. Furthermore, as a humectant, D-panthenol, avocado extract, almond oil, carob extract, rice extract, strawberry extract, fennel extract, euglena extract, olive oil extract, olive oil, odorifera extract, cacao butter, Oat extract, Kizuta extract, Kumaza extract, Gardenia extract, Grapefruit extract, Gentian shochu extract, Gentian extract, Burdock extract, Kokopachiru extract, Sesame extract, Cactus extract, Cactus extract, Ginger extract , Ginger extract, Shea butter, Citrus extract, Senkyu extract, Zeni mushroom extract, Periwinkle extract, Camellia extract, Corn extract, Red pepper extract, Tormentilla extract, Dokudami extract, Bakumondou extract, Hauchi bean extract, ham Squirrel extract, mint extract, green mint extract, Atlantic mint extract, parsley extract, rose extract, sunflower extract, cypress extract, loofah extract, prune extract, butcher's bloom extract, borage oil, button Extract, Jojoba oil, Bodaige extract, Hop extract, Pine extract, Maronier extract, Macadamia nut oil, Quince extract, Murasaki extract, Meadow home oil, Melissa extract, Cornflower extract, Lily extract, Yuzu Examples include an extract, a lime extract, a lavender extract, a gentian extract, a bitumen extract, and an apple extract. One or two or more moisturizers listed above can be appropriately selected and blended.

  Examples of vitamins and derivatives and salts thereof include vitamin Ks such as phytonadione, menaquinone, menadione and menadiol, vitamins P such as eriocitrin and hesperidin, biotin, carcinine and ferulic acid. Examples of the blood circulation promoter include nonyl acid wallenylamide, capsaicin, gingerone, cantalis tincture, ictamol, α-borneol, inositol hexanicotinate, cyclandrate, cinnarizine, trazoline, acetylcholine, verapamil, γ-oryzanol and the like. Examples thereof include esters, sulfate esters, palmitic acid esters, stearic acid esters, succinic acid esters and salts thereof such as sodium, potassium and magnesium. Examples of skin astringents include tannic acid, examples of antiseborrheic agents include thianthol, and examples of enzymes include lipase and papain.

The specific iontophoresis device of the present invention may be structured to be combined with other active ingredient introducers. The other active ingredient introducer may be a simple substance or complex active ingredient introducer selected from a humidifying introducer, a vibration introducing device, an ion introducing device, a sound wave introducing device, and an electromagnetic wave introducing device.
Specifically, those that spray steam on the skin to open pores and introduce medicinal ingredients, those that promote minute blood flow by applying minute vibrations to the skin surface and promote the introduction of medicinal ingredients, ultrasonic vibrations Promotes blood circulation by applying to the skin, promotes the diffusion state of the substance, introduces the substance into the skin, promotes blood circulation by exposing low frequency, high frequency, and medium frequency electromagnetic waves and enhances the permeability of the active ingredient There are things. These may be used in combination of a plurality of these functions instead of a single one. For example, the skin permeability of the components can be increased by simultaneously adding vibration and ultrasonic waves to the iontophoresis device of the present invention.

  The voltage of the iontophoresis device of the present invention can be changed in voltage, current amount, current waveform, and the like by a circuit in the iontophoresis device. Preferably, it is sufficient to apply a voltage of about 0.01 to 10 V to the electrode, but if the DC voltage is used for a long time, it causes side effects such as burns. Positive and negative voltages can be applied. In the case of an AC voltage, 100 Hz to 0.1 Hz is preferable, and even when a DC voltage is applied with positive and negative voltages alternately, it is preferable that the DC voltage is 0.1 to 30 seconds after a length of 0.1 to 30 seconds. A reverse voltage of 01 to 10 seconds is applied, and this is repeated continuously or intermittently. This intermittent time is preferably from 0.01 seconds to 30 seconds. The electrode voltage in this case is preferably 0.01 to 10V. The positive and negative electrodes are placed on different parts of the skin, while one electrode is placed at the position of the skin where ions are introduced. It is desirable that the electrode area be larger so that it is less susceptible to irritation, and the electrode can be attached to the entire face. The electrolyte pack agent or cataplasm of the present invention can be used in place of the electrode. It is also possible to energize the whole skin or part of it by immersing it in the electrolyte bath or lotion of the present invention. The polarity of the electrode placed on the surface of the skin is generally determined by whether the substance to be introduced is charged positively or negatively. L-ascorbine using an electrolytic solution of L-ascorbic acid or an L-ascorbic acid derivative is used. When an acid and its derivative are introduced into the skin, a negative voltage is applied from the outside of the skin because L-ascorbic acid and its derivative are negatively charged. In the case of a complex salt containing a large amount of L-ascorbic acid magnesium phosphate or calcium salt or a derivative salt thereof, the binding force between magnesium or calcium and L-ascorbic acid phosphate is strong, so that it can be sufficiently dissociated in an aqueous solution state. In many cases, molecules are positively charged due to difficulty, and in this case, it is desirable to introduce a positive voltage from the outside of the skin. Further, it is more preferable to apply positive and negative voltages alternately with a time difference even between an AC voltage and a DC voltage because it can deal with any charged substance. In the case of AC voltage, either the type in which the voltage is suddenly switched or the type in which the voltage is gradually switched may be used, but the latter is more preferable because it causes less skin irritation.

  The concentration of the active ingredient used in the iontophoresis device of the present invention varies depending on the blending amount (content) of the salt, but preferably 0.001 to 50% by weight (hereinafter referred to as “% by weight”) as the dry solid content. Indicated by “%”). If the amount (content) of this salt is less than 0.001%, a sufficient effect may not be obtained, and even if it exceeds 50%, no further increase in effect is observed.

  An anti-inflammatory agent can also be added to the composition of active ingredients that can be used in the iontophoresis device of the present invention. Anti-inflammatory agents that can be used in the present invention include zinc oxide, sulfur and derivatives thereof, glycyrrhizic acid, dipotassium glycyrrhizinate, monoammonium glycyrrhizinate and derivatives thereof, and salts thereof, β-glycyrrhetinic acid, glycyrrhetinic acid Stearyl, glycyrrhetinic acid such as disodium 3-succinyloxyglycyrrhetinate and its derivatives, and salts thereof, tranexamic acid, chondroitin sulfate, mefenamic acid, phenylbutazone, indomethacin, ibuprofen, ketoprofen, allantoin, guaiazulene, and derivatives thereof Salt, ε-aminocaproic acid, diclofenac sodium, aloe extract, altea extract, arnica extract, ashitaba extract, ginseng extract, nettle extract Extracts, Turmeric extract, Oat extract, Hypericum extract, Chamomile extract, Snapdragon extract, Watercress extract, Comfrey extract, Salvia extract, Shikon extract, Perilla extract, Birch extract, Tokisenka An extract, an elder extract, a cinnamon extract, a mugwort extract, a forsythia extract, a mugwort extract, a eucalyptus extract, etc. are mentioned. One or two or more of these anti-inflammatory agents can be appropriately selected and blended.

  Among these anti-inflammatory agents, particularly preferred are glycyrrhizic acid, glycyrrhetinic acid, indomethacin, allantoin, guaiazulene and derivatives thereof, and their salts, aloe extract, ginseng extract, hypericum extract, comfrey extract, Examples include sicon extract and mukuroji extract. The blending amount (content) of the anti-inflammatory agent is not particularly limited, but is preferably 0.00001 to 20%, more preferably 0.0001 to 10%. When a plant extract or the like is used as an extract, the amount is in terms of dry solid content.

The dosage form of the composition which mix | blends the active ingredient which can be used for the iontophoresis device of this invention is not specifically limited. Specific examples thereof include skin care cosmetics such as emulsions, creams, gels, lotions, cosmetic liquids, packs, bath preparations, cleaning agents, etc., pharmaceuticals such as ointments, poultices, dispersions, creams, and liquids for external use. The dosage form is not particularly limited, and may be liquid, paste, mousse, gel, powder, solution, solubilization, emulsification, powder dispersion, or multilayer. it can. In particular, emulsions, creams, gels, lotions, cosmetics, and packs are suitable because of their high water content and good electrolyte conductivity. In addition, the dosage form containing an active ingredient that can be used in the iontophoresis device of the present invention is usually used for preparations such as cosmetics, quasi-drugs, and external medicines, as long as the effects of the present invention are not impaired. Ingredients, ie, water (purified water, hot spring water, deep layer water, etc.), oil agent, surfactant, metal soap, gelling agent, powder, alcohols, water-soluble polymer, film forming agent, resin, UV protection agent , Inclusion compounds, antibacterial agents, fragrances, deodorants, salts, pH adjusters, refreshing agents, animal / microbe-derived extracts, plant extracts, blood circulation promoters, astringents, antiseborrheic agents, active oxygen scavengers Cell activators, moisturizers, keratolytic agents, enzymes, hormones, vitamins and the like can be appropriately added singly or in combination. The amount of these components to be added is not particularly limited, but can usually be added in the range of 0.0001% to 80%. A plurality of these raw materials can be used in combination. The mask sheet functions as a carrier that supports the active ingredient, and can impart good operability and a feeling of use to the tissue. Although it can use without being specifically limited as a raw material of a mask sheet | seat, the sheet | seat or film which has moisture permeability is used suitably. For example, by using a porous film, moisture permeability can be further increased, and since bacterial invasion to the wound is suppressed, bacterial infection can be prevented. Examples of the material for the mask sheet of the present invention include paper, cloth, non-woven fabric, and plastic film. Examples of the material include cellulose and polyolefins such as polyethylene and polypropylene; polyesters such as polyethylene terephthalate and polybutylene terephthalate; nylons and the like. Polyamide; polyurethane and the like. Among these, polyurethane excellent in moisture permeability and stretchability is preferable. The plastic film may be either an unstretched film or a stretched (uniaxially stretched or biaxially stretched) film. For example, in the case of an unstretched film, additives for forming micropores are mixed and dispersed in the resin. And it can be made into a porous film by well-known methods, such as the extraction method which removes an additive after shaping | molding. Moreover, it is possible to obtain a porous film also by the well-known extending | stretching method of extending | stretching a resin composition. Here, the porous film means one in which micropores communicate with both surfaces of the film. Specific examples of materials that can be used as the mask sheet of the present invention include a face mask sheet (manufactured by ITO), tegaderm (manufactured by 3M), opsound (manufactured by Smith & Nephew), and IV3000 (manufactured by Smith & Nepnew). ), Polyurethane film and dressing materials such as bio-exclusive (manufactured by Johnson & Johnson). Hydrocolloid dressing materials such as Duoactive (manufactured by Convatec), Comfeel (manufactured by Coloplast), Tegasorb (manufactured by 3M), Absolute Cure (manufactured by Nitto Medical). Polyurethane foam dressing materials such as Hydrosite (Smith & Nephew). Polyurethane foam dressing materials such as Cultstat (manufactured by Convatec), Sorbusan (manufactured by Arcea), Algodame (manufactured by Medicon), Clavio AG (manufactured by Kuraray). Hydrogel dressing materials such as Jeripalm (Bamboo Tiger), New Gel (Johnson & Johnson), Intrasite (Smith & Nephew), Granugel (Convatec), Clearsite (Japan Sigmax). It is also possible to use a hydropolymer material of Thiers (manufactured by Johnson & Johnson). Moreover, although the magnitude | size of a mask sheet | seat can be suitably selected according to a use purpose, For example, thickness is 10 micrometers-5 mm normally. Thereby, operativity and usability can be made favorable. The mask sheet can be coated with an adhesive to improve the adhesion to the skin, and has a function of fixing the wound dressing to the skin surface. The pressure-sensitive adhesive is not particularly limited as long as it has water absorption or water swellability, but a hydrocolloid pressure-sensitive adhesive is suitable. Thereby, since cold flow property becomes favorable, it is excellent in the adhesiveness with respect to a skin surface, and can prevent the bacterial infection from the outside. In addition, when the water absorption is poor, the exudate is stored in the fabric when there is a large amount of exudate, which may adversely affect the wound. The hydrocolloid adhesive is composed of a mixed dispersion containing an elastomer and a water-absorbing substance. The elastomer imparts appropriate cohesiveness to the pressure-sensitive adhesive layer, and contributes to preventing the pressure-sensitive adhesive from bleeding after the pressure-sensitive adhesive layer is formed. Examples of elastomers include polyisobutylene, polyisoprene, polybutadiene, styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, natural rubber, silicone-based polymer mainly composed of polymethylsiloxane, polyvinyl Examples include ether polymers. Among these, from the viewpoint of cold flow resistance, polyisobutylene is preferable, and it is more preferable to use polyisoprene in combination in order to improve cohesion. In that case, it is desirable to blend polyisoprene within a range not exceeding 50% by weight with respect to the total weight of polyisobutylene and polyisoprene. In the present invention, the elastomers can be used alone or in combination of two or more. The viscosity average molecular weight (Mv) of the elastomer is preferably 35,000 to 1,500,000. When Mv is less than 10,000, the cohesive force of the pressure-sensitive adhesive layer tends to decrease, and when it exceeds 2,000,000, the water absorption property of the pressure-sensitive adhesive layer tends to decrease.

  As an oil agent, as long as it is used for normal cosmetics, it is a natural oil, a synthetic oil, or a solid, semi-solid, liquid, etc. , Waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorinated oils, and the like can be used. For example, hydrocarbons such as squalane, squalene, ceresin, paraffin, paraffin wax, liquid paraffin, pristane, polyisobutylene, microcrystalline wax, petrolatum; waxes such as beeswax, carnauba wax, candelilla wax, whale wax; beef tallow, cow Animal oils such as leg fat, beef bone fat, hard beef fat, hard oil, turtle oil, pork fat, horse fat, mink oil, liver oil, egg yolk oil; lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, lanolin acetate, Lanolin derivatives such as lanolin fatty acid isopropyl, POE lanolin alcohol ether, POE lanolin alcohol acetate, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether; lauric acid, myristic acid, palmitic acid, stearin , Behenic acid, undecylenic acid, oleic acid, arachidonic acid, docosahexaenoic acid (DHA), isostearic acid, fatty acids such as 12-hydroxystearic acid.

  As an oil agent, lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, oleyl alcohol, isostearyl alcohol, hexyl decanol, octyldodecanol, cetostearyl alcohol, 2-decyltetradecinol, Higher alcohols such as cholesterol, phytosterol, sitosterol, lanosterol, POE cholesterol ether, monostearyl glycerine ether (batyl alcohol); diisobutyl adipate, 2-hexyldecyl adipate, di-2-heptyl undecyl adipate, monoisostearin Acid-N-alkyl glycol, isocetyl isostearate, trimethylol triisostearate Bread, ethylene glycol di-2-ethylhexanoate, cetyl 2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, octyldodecyl gum ester, olein Oleyl acid, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, triethyl citrate, 2-ethylhexyl succinate, amyl acetate, ethyl acetate, butyl acetate, isocetyl stearate, butyl stearate, diisopropyl sebacate, Di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptyl palmitate Decyl, cholesteryl 12-hydroxystearylate, dipentaerythritol fatty acid ester, isopropyl myristate, octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, Examples include ester oils such as N-lauroyl-L-glutamic acid-2-octyldodecyl ester and diisostearyl malate.

  Furthermore, as an oil agent, acetoglyceride, triisooctanoic acid glyceride, triisostearic acid glyceride, triisopalmitic acid glyceride, tri-2-ethylhexanoic acid glyceride, monostearic acid glyceride, di-2-heptylundecanoic acid glyceride, trimyristic acid Glyceride oil such as glyceride; dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydrogencyclotetrasiloxane, stearoxy Higher alkoxy-modified silicones such as silicone; higher fatty acid-modified silicones, silicone resins, silicone rubber, silicon Silicone-based oil agent over emissions oil; perfluoropolyether, perfluorodecalin, fluorine-based oils of perfluoro octane.

  In the active ingredient for mask sheet printing of the present invention, various pigments used for printing inks, paints and the like can be blended in the pigment. When these pigments are represented by color index, Pigment Black 7, Pigment Blue 15, 15: 1, 15: 3, 15: 4, 15: 6, 60, Pigment Green 7, 36, Pigment Red 9, 48, 49 , 52, 53, 57, 97, 122, 149, 168, 177, 178, 179, 206, 207, 209, 242, 254, 255, pigment violet 19, 23, 29, 30, 37, 40, 50, pigment Yellow 12, 13, 14, 17, 20, 24, 74, 83, 86, 93, 94, 95, 109, 110, 117, 120, 125, 128, 137, 138, 139, 147, 148, 150, 151 , 154, 155, 166, 168, 180, 185, pigment orange 36, 43, 51, 55, 59 61,71,74, and the like. As for carbon black, any carbon black such as neutral, acidic and basic can be used. These pigments are desirably contained in an amount of 0.01 to 10% by weight. In the present invention, it is preferable to add a dispersant in order to improve the dispersibility and storage stability of the active ingredient. Examples of the dispersant include a hydroxyl group-containing carboxylic acid ester, a salt of a long-chain polyaminoamide and a high molecular weight acid ester, a salt of a high molecular weight polycarboxylic acid, a salt of a long chain polyaminoamide and a polar acid ester, a high molecular weight unsaturated acid ester, Molecular copolymer, modified polyurethane, modified polyacrylate, polyether ester type anionic activator, naphthalene sulfonic acid formalin condensate salt, aromatic sulfonic acid formalin condensate salt, polyoxyethylene alkyl phosphate ester, polyoxyethylene nonyl Phenyl ether, stearylamine acetate, etc. can be used. Specific examples of the dispersant include “Anti-Terra-U (polyaminoamide phosphate)”, “Anti-Terra-203 / 204 (high molecular weight polycarboxylate)”, “Disperbyk-101” (polyamino) manufactured by BYK Chemie. Amide phosphate and acid ester), 107 (hydroxyl group-containing carboxylic acid ester), 110, 111 (copolymer containing acid group), 130 (polyamide), 161, 162, 163, 164, 165, 166, 170 (high Molecular copolymer) ”,“ 400 ”,“ Bykumen ”(high molecular weight unsaturated acid ester),“ BYK-P104, P105 (high molecular weight unsaturated acid polycarboxylic acid) ”,“ P104S, 240S (high molecular weight unsaturated) Acid polycarboxylic acid and silicon system "," Lactimon (long chain amine and unsaturated acid poly) Carboxylic acid and silicon) "can be mentioned. Also, “Efka CHEMICALS” “Efka 44, 46, 47, 48, 49, 54, 63, 64, 65, 66, 71, 701, 764, 766”, “Efka Polymer 100 (modified polyacrylate), 150 (aliphatic) System modified polymer), 400, 401, 402, 403, 450, 451, 452, 453 (modified polyacrylate), 745 (copper phthalocyanine system) "," Floren TG-710 (urethane oligomer) "," Flownon "manufactured by Kyoeisha Chemical Co., Ltd. “SH-290, SP-1000”, “Polyflow No. 50E, No. 300 (acrylic copolymer)”, “Disparon KS-860, 873SN, 874 (polymer dispersing agent), # 2150 (manufactured by Enomoto Kasei Co., Ltd.) Aliphatic polyvalent carboxylic acid), # 7004 (polyether ester type) ” That. Further, “Demol RN, N (Naphthalenesulfonic acid formalin condensate sodium salt), MS, C, SN-B (aromatic sulfonic acid formalin condensate sodium salt), EP”, “Homogenol L-18 (poly) Carboxylic acid type polymer), “Emulgen 920, 930, 931, 935, 950, 985 (polyoxyethylene nonyl phenyl ether)”, “Acetamine 24 (coconut amine acetate), 86 (stearyl amine acetate)”, manufactured by Lubrizol “Solspers 5000 (phthalocyanine ammonium salt type), 13940 (polyesteramine type), 17000 (fatty acid amine type), 24000”, “Nikkor T106 (polyoxyethylene sorbitan monooleate), MYS-IEX (polyoxyl) manufactured by Nikko Chemical Co., Ltd.” Ethylene monostearate), Hexagline 4-0 (hexaglyceryl ruthenate Huwei Rate) ", Ajinomoto Fine-Techno Co., Ltd.," AJISPER PB821, PB822 (basic dispersant) ", and the like. The dispersant is preferably contained in the ink in an amount of 0.1 to 10% by weight. In the present invention, a resin may be added to improve the adhesion to the mask sheet. Usable resins include acrylic resin, styrene-acrylic resin, styrene-maleic resin, rosin resin, rosin ester resin, ethylene-vinyl acetate resin, petroleum resin, coumarone indene resin, terpene phenol Resin, phenol resin, urethane resin, melamine resin, urea resin, epoxy resin, cellulose resin, vinyl acetate resin, xylene resin, alkyd resin, aliphatic hydrocarbon resin, butyral resin, maleic acid resin, fumaric acid Examples thereof include resins. Specific examples of the resin include Superester 75 manufactured by Arakawa Chemical Co., Ltd., Ester Gum HP, Malkid 33, YS Polystar T80 manufactured by Yasuhara, Hirtts HRT200X manufactured by Mitsui Chemicals, Jonkrill 586 manufactured by Johnson Polymer, Dow Chemicals Examples include Uker solution vinyl resins VYHD, VYHH, VMCA, VROH, VYLF-X, and solvin resins CL, CNL, C5R, and TA5R manufactured by Nissin Kagaku Kogyo. Various additives such as a plasticizer, a surface conditioner, an ultraviolet light inhibitor, a light stabilizer, an antioxidant and a hydrolysis inhibitor can be used as the active ingredient of the present invention. Examples of the non-absorbable substrate of the present invention include a polyvinyl chloride resin sheet, a polyolefin-based sheet, glass, metal and the like, and a polyvinyl chloride resin sheet is particularly preferable. Examples of the printing method of the active ingredient according to claim 1 of the present invention include gravure printing, flexographic printing, silk screen printing, ink jet printing, and the like, and the ink jet printing method is particularly preferable. The active ingredient of the present invention is obtained by first dispersing a pigment in a single or mixed solvent with a resin or a dispersant using a paint shaker, sand mill, roll mill, medialess disperser or the like for printing. It is manufactured by diluting with the solvent of the present invention.

As the surfactant that can be added to the composition containing the active ingredient of the present invention and the mask sheet, anionic, cationic, nonionic and amphoteric active agents are used, but the anionic or cationic active agent is more iontophoretic. It is more preferable because it is easy to do. However, non-ionic interfaces are effective for formulating to increase the stability of the formulation.
Examples of anionic surfactants include fatty acid soaps such as sodium stearate and triethanolamine palmitate, alkyl ether carboxylic acids and salts thereof, carboxylates such as condensates of amino acids and fatty acids, alkyl sulfonic acids, and alkene sulfonates. Sulfonates of fatty acid esters, sulfonates of fatty acid amides, sulfonates of alkyl sulfonates and their formalin condensates, alkyl sulfate esters, secondary higher alcohol sulfates, alkyl and allyl ether sulfates , Sulfate ester of fatty acid ester, sulfate ester of fatty acid alkylolamide, sulfate ester salt such as funnel oil, alkyl phosphate, ether phosphate, alkyl allyl ether phosphate, amide phosphate, N-acyl amino acid System active agents It is.

  Cationic surfactants that can be added to the composition and mask sheet containing the active ingredient of the present invention include alkylamine salts, amine salts such as polyamines and aminoalcohol fatty acid derivatives, alkyl quaternary ammonium salts, aromatic quaternary ammoniums. Salts, pyridium salts, imidazolium salts and the like. Nonionic surfactants include sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, propylene glycol fatty acid ester, polyethylene glycol fatty acid ester, sucrose fatty acid ester, polyoxyethylene alkyl ether, polyoxypropylene alkyl ether, poly Oxyethylene alkyl phenyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, polyoxyethylene sorbitol fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene propylene glycol fatty acid ester, polyoxyethylene castor oil, polyoxyethylene Hydrogenated castor oil, polyoxyethylene phytostanol ether, polyoxyethylene Down phytosterol ether, polyoxyethylene cholestanol ether, polyoxyethylene cholesteryl ether, polyoxyalkylene-modified organopolysiloxane, polyoxyalkylene-alkyl co-modified organopolysiloxane, alkanolamide, sugar ethers, and sugar amides. Examples of amphoteric surfactants include betaines, aminocarboxylates, imidazoline derivatives, and the like.

Examples of the metal soap that can be added to the composition and mask sheet containing the active ingredient of the present invention include 12-hydroxy aluminum stearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate Zinc cetyl phosphate, calcium cetyl phosphate, sodium cetyl phosphate, zinc laurate, zinc undecylenate and the like.
Gelling agents include amino acid derivatives such as N-lauroyl-L-glutamic acid, α, γ-di-n-butylamine, dextrins such as dextrin palmitate, dextrin stearate, dextrin 2-ethylhexanoate palmitate, etc. Fatty acid esters, sucrose palmitate, sucrose fatty acid esters such as sucrose stearate, monobenzylidene sorbitol, benzylidene derivatives of sorbitol such as dibenzylidene sorbitol, dimethylbenzyl dodecyl ammonium montmorillonite clay, dimethyl dioctadecyl ammonium montmorillonite clay, etc. Examples include organically modified clay minerals.

  As the powder that can be added to the composition and the mask sheet containing the active ingredient of the present invention, the shape (spherical, needle-like, plate-like, etc.) and particle diameter ( Any material such as inorganic powder, organic powder, and pigment can be used regardless of the shape of the smoke, fine particles, pigment grade, etc.) and particle structure (porous, non-porous, etc.). For example, as the inorganic powder, magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, synthetic mica, mica, kaolin, sericite, muscovite, synthetic mica, phlogopite, saucite, Biotite, lithia mica, silicic acid, anhydrous silicic acid, aluminum silicate, magnesium silicate, magnesium aluminum silicate, sulfur-containing aluminum silicate, calcium silicate, barium silicate, strontium silicate, metal tungstate, hydroxy Examples thereof include apatite, vermiculite, hydrite, montmorillonite, zeolite, ceramic powder, dicalcium phosphate, alumina, aluminum hydroxide, boron nitride, and boron nitride.

  Organic powders that can be added to the composition and mask sheet containing the active ingredient of the present invention include polyamide powder, polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene Powder, polymethylmethacrylate powder, silk powder, nylon powder, 12 nylon, 6 nylon, styrene / acrylic acid copolymer, divinylbenzene / styrene copolymer, vinyl resin, urea resin, phenol resin, fluorine resin, silicon resin, Acrylic resin, melamine resin, epoxy resin, polycarbonate resin, microcrystalline fiber powder, lauroyl lysine and the like can be mentioned.

  Examples of colored pigments that can be added to the composition containing the active ingredient of the present invention include inorganic red pigments such as iron oxide, iron hydroxide, and iron titanate, inorganic brown pigments such as γ-iron oxide, yellow iron oxide, and loess. Inorganic yellow pigments, inorganic black pigments such as black iron oxide and carbon black, inorganic purple pigments such as manganese violet and cobalt violet, inorganic green pigments such as chromium hydroxide, chromium oxide, cobalt oxide and cobalt titanate, bitumen, Examples thereof include inorganic blue pigments such as ultramarine blue, pigments obtained by lacquering tar pigments, pigments obtained by lacquering natural pigments, and composite powders obtained by combining these powders. Examples of the pearl pigment include titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, fish scale foil, and titanium oxide-coated colored mica. Examples of the metal powder pigment include aluminum powder, copper powder, and stainless steel powder.

  Examples of tar dyes that can be added to the composition containing the active ingredient of the present invention include Red No. 3, Red No. 104, Red No. 106, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red 226, Red 227, Red 228, Red 230, Red 401, Red 505, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Yellow 204, Yellow 401, Blue 1 No. 2, Blue No. 2, Blue No. 201, Blue No. 404, Green No. 3, Green No. 201, Green No. 204, Green No. 205, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 206, Orange No. 207, etc. Is mentioned. Examples of natural pigments include carminic acid, laccaic acid, calsamine, bradylin, and crocin. The above-mentioned powders such as inorganic powder, organic powder, pigment, and tar dye may be composited or surface-treated with an oil agent, silicone, or fluorine compound.

The ultraviolet absorber is also effective for enhancing the stability of the composition containing the active ingredient of the present invention and the mask sheet. Usable UV protection agents include: 2-methoxyhexyl paramethoxycinnamate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamic acid, diparamethoxycinnamic acid-glyceryl mono-2-ethylhexanoate Cinnamate UV absorbers such as octyl methoxycinnamate and methyl diisopropylcinnamate; 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfate, 2-hydroxy-4- Methoxybenzophenone-5-sodium sulfate, 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2′-dihydroxy-4-methoxybenzophenone, 2,2 ′, 4,4 '-Tetrahydroxybenzophenone, 2-hydride Benzophenone ultraviolet absorbers such as xyl-4-n-octoxybenzophenone; paraaminobenzoic acid, ethyl paraaminobenzoate, butyl paraaminobenzoate, paradimethylaminobenzoic acid-2-ethylhexyl, glyceryl paraaminobenzoate, amyl paraaminobenzoate And benzoic acid-based ultraviolet absorbers. Further, as UV protection agents, salicylic acid such as 2-ethylhexyl salicylate, triethanolamine salicylate, homomenthyl salicylate, dipropylene glycol salicylate, methyl salicylate, ethylene glycol salicylate, phenyl salicylate, amyl salicylate, benzyl salicylate, isopropylbenzyl salicylate, potassium salicylate, etc. Type ultraviolet absorbers; dibenzoyl such as 4-t-butyl-4′-methoxydibenzoylmethane, 4-isopropyldibenzoylmethane, 4-methoxydibenzoylmethane, 4-t-butyl-4′-hydroxydibenzoylmethane Methane ultraviolet absorber; menthyl-O-aminobenzoate, 2-phenyl-benzimidazole-5-sulfate, 2-phenyl-5-methylbenzoxazole, 3- (4- Tylbenzylidene) camphor, 2-ethylhexyl-2-cyano-3,3-diphenyl acrylate, 2-ethyl-2-cyano-3,3′-diphenyl acrylate, 2- (2′-hydroxy-5-methylphenyl) benzo Examples include anthranilic acid ultraviolet absorbers such as triazole and menthyl anthranilate; urocanic acid ultraviolet absorbers such as ethyl urocanate; titanium oxide, zirconium oxide, and cerium oxide.
Examples of alcohols include lower alcohols such as ethanol and isopropanol, polyhydric alcohols such as glycerin, diglycerin, ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, and polyethylene glycol. Is mentioned.

Examples of the water-soluble polymer that can be added to the composition and mask sheet containing the active ingredient of the present invention include gum arabic, tragacanth, galactan, carob gum, guar gum, caraya gum, carrageenan, pectin, agar, alge colloid, trant gum, locust bean gum Plant polymers such as galactomannan; microbial polymers such as xanthan gum, dextran, succinoglucan, pullulan; animal polymers such as casein, albumin, gelatin; starch, carboxymethyl starch, methylhydroxypropyl starch, etc. Starch polymer; methylcellulose, ethylcellulose, methylhydroxypropylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, nitrocellulose, Cellulose polymers such as sodium roulose sulfate, sodium carboxymethylcellulose, crystalline cellulose, cellulose powder; alginic acid polymers such as sodium alginate and propylene glycol alginate; vinyl systems such as polyvinyl methyl ether, carboxyvinyl polymer, and alkyl-modified carboxyvinyl polymer Polymer: Polyoxyethylene polymer; Polyoxyethylene polyoxypropylene copolymer polymer; Acrylic polymer such as sodium polyacrylate, polyethyl acrylate, polyacrylamide; polyethyleneimine, cationic polymer, bentonite, laponite, There are inorganic water-soluble polymers such as hectorite. Also included are film forming agents such as polyvinyl alcohol and polyvinyl pyrrolidone.
Antibacterial agents include benzoic acid, sodium benzoate, coalic acid, sorbic acid, potassium sorbate, paraoxybenzoic acid ester, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, Bis (2-pyridylthio-1-oxide) zinc, phenoxyethanol and thianthol, isopropylmethylphenol and the like can be mentioned. Examples of the pH adjusting agent include potassium carbonate, sodium hydrogen carbonate, ammonium hydrogen carbonate and the like. Examples of the refreshing agent include L-menthol and camphor.

Examples of the present invention will be described below.
Example 1
Small disposable iontophoresis device applied to cosmetic caps 8 ml of an aqueous solution of AP5 lotion manufactured by ITO Co., Ltd. dissolved in 5% weight of sodium ascorbate phosphate powder manufactured by ITO Co., Ltd. face manufactured by ITO Co., Ltd. The mask sheet was soaked into the mask sheet and attached to the face. Next, ion introduction was performed for 15 minutes from the top of the mask sheet with the following disposable iontophoresis device of the present invention.
A in the figure is a zinc electrode installed at a target site on the body surface such as the face. B is a copper electrode with which the finger of the hand is brought into contact. When the portion B was pinched with a fingertip and contacted with a face mask sheet with A attached to the face of the same person, a voltage of 535 mV was generated between AB and the A pole was negatively charged. As a result, negatively ionized ascorbic acid phosphate in the mask sheet near the A electrode could be effectively ionized into the skin by the following test. E is a screw hole for bonding to a cosmetic container containing a 3% solution of sodium ascorbate phosphate.
[Fig. 6]

Example 2 Efficacy Test for Acne Twelve men and women between the ages of 25 and 67 who suffer from acne were washed face by face twice a day in the morning and evening according to the method of Example 1 in the same manner as in Example 1 and sodium ascorbate phosphate. This was continued for 3 months. It should be noted that the right side of the face uses the iontophoresis device of Example 1 of the present invention, and the left side of the face uses a control device in which the electrode A and the electrode B are shorted with a copper wire to eliminate the ion introduction effect. The effect was compared.
Three months later, the number of acne was counted and compared with the number of acne at the start of the experiment. As a result, the number of acne on the right face using the iontophoresis device of the present invention was 100% at the start of the experiment. Compared with the average value, it decreased drastically to 14%, and acne improved. In the left control, the number of acne decreased on average to 43%, but the right side using the iontophoresis device of the present invention improved significantly more than the left side of the control.

Example 3 Percutaneous absorption test Phosphoric acid ascorbate was prepared in the same manner as in Example 1 using 1 square cm (1 cm × 1 cm) of the same face mask sheet as in Example 1 on the back skin surface of 20 5-week-old male hairless mice. Sodium acid was ion-introduced for 15 minutes. Three hours later, the ion-introduced skin was removed from the back of the mouse, and the sodium ascorbate phosphate concentration in the skin was measured by high performance liquid chromatography. Using the iontophoresis device in which the electrode A and the electrode B used in Example 2 were short-circuited with a copper wire as a control group, the sodium ascorbate phosphate concentration in the skin was similarly measured, and the effect of the iontophoresis device of the present invention It was confirmed. As a result, on average, ascorbic acid concentration in the skin was found to be 3.2 times higher on the skin using the iontophoresis device of the present invention than on the control skin, and the effectiveness of the iontophoresis device of the present invention was detected. Sex was confirmed.

Example 4
In place of the negative electrode of the present invention, the electrode of Al, Zn, Fe, Ni, and the electrode containing 0.1% by weight of trace metals of K, Ca, Na, Mg in the Fe electrode, plus Instead of the electrode copper electrode, Sn, Cu, Ag, Pt, and Au were also prototyped and the voltage was measured. As a result, in the same experimental system as in Example 1, an ion introduction voltage of 212 mV or higher was obtained in all combinations of the negative electrode metal and the positive electrode metal. From these results, it was confirmed that the same ion introduction effect was obtained even in the combination of these electrodes. When a similar experiment was performed in a combination of metals having almost no ionization tendency as a control group (a combination of metals having different minus poles and a combination of metals having different plus electrodes), the ion introduction voltage was −18 at the instantaneous maximum voltage. To +21 mV, which is 1/10 or less of the iontophoresis device of the present invention. In addition, it was found that the voltage of the control device was constantly fluctuating and not constant, sometimes becoming positive and sometimes negative, and could not be used as an iontophoresis device at all.

Example 5
When the iontophoresis device of the present invention was used in the same manner as in Example 1, the following medicinal components whitening effect, acne suppression effect, wrinkle improvement effect, pore reduction effect, tarmi improvement effect, bear suppression effect, moisture retention improvement effect, It was found that the wound healing effect, the infection improvement effect, and the atopy improvement effect are enhanced. However, the following medicinal ingredients are Nanomic capsules manufactured by ITO Co., Ltd. (glycerin 20%, ascorbic acid palmitate Na 1%, surfactin 3%, jojoba oil 40%, the following active ingredients 1%, purified water remaining Minute), an iontophoretic nanocapsule having an average particle diameter of 312 nm was prepared and ion-introduced. All the above are weight percent.
Ascorbic acid, citric acid, tryptophan, hydroxyproline, proline, cysteine, methionine, lysine, leucine, arginine, alanine, serotonin, glycine, tyrosine, serotonin, melatonin, tranexamic acid, glycolic acid, hydroquinone, retinoic acid, astaxanthin, ascorbic acid Mg phosphate, Na tocopheryl phosphate, tocopheryl dimethyl glycine, fullerene, linolenic acid, linoleic acid, tocotrienol, ceramide, hydrolyzed hyaluronic acid, hydrolyzed collagen, hydroxycitric acid, kojic acid, ellagic acid, lipopolysaccharide , Arbutin, boronophenylalanine

Examples of preparations of active ingredients that can be used in the iontophoresis device of the present invention are shown below.
Reference example. 1
Example of lotion preparation (formulation) (%)
(1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20E.O.) sorbitan 1.2 monolaurate (4) Ethyl alcohol 8.0 (5) L -Complex salt of ascorbic acid derivative * 1 1.0 (6) Astaxanthin * 2 0.001 (7) Preservative appropriate amount (8) Fragrance appropriate amount (9) Purified water remaining amount * 1 Manufactured in Reference Example 1 and Reference Example 2 * 2 Manufactured by Sigma
A. Components (3), (4), (6), (7) and (8) are mixed and dissolved.
B. Components (1), (2), (5) and (9) are mixed and dissolved.
C. A and B were mixed and uniformed to obtain a skin lotion.

Reference example. 2 Example of preparation of lotion (formulation) (%)
(1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20E.O.) sorbitan 1.2 monolaurate (4) Ethyl alcohol 8.0 (5) L -Complex salt of ascorbic acid derivative * 1 1.0 (6) Oolong tea extract * 2 1.0 (7) Gokahi extract * 3 1.0 (8) Preservative appropriate amount (9) Fragrance appropriate amount (10) Purified water Residual amount * 1 Produced in Reference Example 1 and Reference Example 2 * 2 Made by Maruzen Pharmaceutical Co., Ltd. * 3 Made by Maruzen Pharmaceutical Co., Ltd. (production method)
A. Components (3), (4), (8) and (9) are mixed and dissolved.
B. Components (1), (2), (5) to (7) and (10) are mixed and dissolved.
C. A and B were mixed and uniformed to obtain a skin lotion.

Reference example. 3
Example of lotion preparation (formulation) (%)
(1) Glycerin 5.0 (2) 1,3-butylene glycol 6.5 (3) Polyoxyethylene (20E.O.) sorbitan 1.2 monolaurate (4) Ethyl alcohol 8.0 (5) L -Complex salt of ascorbic acid derivative * 1 1.0 (6) Aloe extract * 2 1.0 (7) Cayce extract * 3 1.0 (8) Preservative appropriate amount (9) Fragrance appropriate amount (10) Purified water Residual amount * 1 Produced in Reference Example 1 and Reference Example 2 * 2 Made by Maruzen Pharmaceutical Co., Ltd. * 3 Made by Maruzen Pharmaceutical Co., Ltd. (production method)
A. Components (3), (4), (8) and (9) are mixed and dissolved.
B. Components (1), (2), (5) to (7) and (10) are mixed and dissolved.
C. A and B were mixed and uniformed to obtain a skin lotion.

Reference example. 4). Emulsion preparation example (formulation) (%)
(1) Polyoxyethylene (10E.O.) sorbitan 1.0 monostearate (2) Polyoxyethylene (60E.O.) sorbit 0.5 tetraoleate (3) Glyceryl monostearate 1.0 (4 ) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) Complex salt of L-ascorbic acid derivative * 1 5.0 (8) Ibuquitorano extract * 2 0.1 (9 ) Preservative 0.1 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Purified water Remaining (14) Fragrance Appropriate amount * 1 Reference Example 1 and Manufactured in Reference Example 2 * 2 Made by Koei Kogyo Co., Ltd.
A. Ingredients (9) to (13) are heated and mixed and maintained at 70 ° C.
B. Ingredients (1) to (6) are heated and mixed and maintained at 70 ° C.
C. A is added to B, mixed and uniformly emulsified.
D. After cooling C, (7), (8) and (14) were added and mixed uniformly to obtain an emulsion.

Reference example. 5
Emulsion preparation example (formulation) (%)
(1) Polyoxyethylene (10E.O.) sorbitan 1.0 monostearate (2) Polyoxyethylene (60E.O.) sorbit 0.5 tetraoleate (3) Glyceryl monostearate 1.0 (4 ) Stearic acid 0.5 (5) behenyl alcohol 0.5 (6) squalane 8.0 (7) complex salt of L-ascorbic acid derivative * 1 5.0 (8) mucrodi extract * 2 1.0 (9) Preservative 0.1 (10) Carboxyvinyl polymer 0.1 (11) Sodium hydroxide 0.05 (12) Ethyl alcohol 5.0 (13) Purified water Remaining amount (14) Fragrance Appropriate amount * 1 Reference Example 1 and Reference Manufactured in Example 2 * 2 Made by Maruzen Pharmaceutical Co., Ltd. (Production method)
A. Ingredients (9) to (13) are heated and mixed and maintained at 70 ° C.
B. Ingredients (1) to (6) are heated and mixed and maintained at 70 ° C.
C. A is added to B, mixed and uniformly emulsified.
D. After cooling C, components (7), (8) and (14) were added and mixed uniformly to obtain an emulsion.

Reference example. 6
Emulsion preparation example (formulation) (%)
(1) Polyoxyethylene (10E.O.) sorbitan 1.0 monostearate (2) Polyoxyethylene (60E.O.) sorbit 0.5 tetraoleate (3) Glyceryl monostearate 1.0 (4 ) Stearic acid 0.5 (5) Behenyl alcohol 0.5 (6) Squalane 8.0 (7) Complex salt of L-ascorbic acid derivative * 1 5.0 (8) Shikon extract * 2 1.0 (9) Hypericum extract * 3 1.0 (10) Preservative 0.1 (11) Carboxyvinyl polymer 0.1 (12) Sodium hydroxide 0.05 (13) Ethyl alcohol 5.0 (14) Purified water remaining amount ( 15) Perfume Appropriate amount * 1 Produced in Reference Example 1 and Reference Example 2 * 2 Made by Maruzen Pharmaceutical Co., Ltd. * 3 Made by Maruzen Pharmaceutical Co., Ltd. (Production method)
A. Ingredients (10) to (13) are heated and mixed and maintained at 70 ° C.
B. Ingredients (1) to (6) are heated and mixed and maintained at 70 ° C.
C. A is added to B, mixed and uniformly emulsified.
D. After cooling C, components (7) to (9) and (14) were added and mixed uniformly to obtain an emulsion.

  Both the lotion and milky lotion of the above reference example are excellent in stability over time, and are applied to the iontophoresis device of the embodiment of the present invention to prevent skin dullness, spots and freckles due to sunburn, and have a transparent feeling. It was to make beautiful skin.

Reference Example 7 Pack preparation example (formulation) (%)
(1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerol 5.0 (4) Kaolin 6.0 (5) Complex salt of L-ascorbic acid derivative * 1 0.05 (6) Maika Extract * 2 0.2 (7) Preservative 0.2 (8) Fragrance 0.1 (9) Purified water Residual amount * 1 Produced in Reference Examples 1 and 2 * 2 Made by Maruzen Pharmaceutical Co., Ltd.

(Manufacturing method)
A. Ingredients (1), (3), (4) and (9) are mixed, heated to 70 ° C. and stirred.
B. Ingredients (2), (7) and (8) are mixed.
C. The above B was added to the previous A, mixed and then cooled to uniformly disperse (5) and (6) to obtain a pack.
Reference Example 7 The pack was excellent in stability over time, and applied to the skin to prevent “dullness” and spots on the skin and to make the skin beautiful and transparent.

Reference Example 8 Preparation Example (Prescription) of Cleaning Material (%)
(1) stearic acid 10.0 (2) palmitic acid 8.0 (3) myristic acid 12.0 (4) lauric acid 4.0 (5) oleyl alcohol 1.5 (6) purified lanolin 1.0 (7 ) Fragrance 0.1 (8) Preservative 0.2 (9) Glycerol 18.0 (10) Potassium hydroxide 6.0 (11) Complex salt of L-ascorbic acid derivative * 1 0.5 (12) Indomethacin * 2 0.01 (13) molasses extract * 3 0.5 (14) remaining amount of purified water * 1 manufactured in Reference Example 1 and Reference Example 2 * 2 manufactured by Sigma * 3 manufactured by Taiyo Kagaku (manufacturing method)
A. Ingredients (9), (10), (12) and (14) are mixed and heated to 70 ° C.
B. Components (1) to (6) and (8) are mixed and heated to 70 ° C.
C. The above B was added to the previous A and kept at 70 ° C. for a while. After the reaction was completed, the mixture was cooled to 50 ° C., components (7), (11) and (13) were added and cooled to obtain a washing material.
The cleaning material of Reference Example 8 was excellent in stability over time, and applied to the iontophoresis device of the present invention to make beautiful skin with no dullness and transparency.

Reference Example 9 Gel ointment preparation example (formulation) (%)
(1) Carboxyvinyl polymer 1.0 (2) Triethanolamine 1.0 (3) 1,3 butylene glycol 10.0 (4) Complex salt of L-ascorbic acid derivative * 1 0.01 (5) Allantoin * 2 0.02 (6) remaining amount of purified water * 1 manufactured in Reference Example 1 and Reference Example 2 * 2 manufactured by Merck & Co. (manufacturing method)
A. Components (1) and (3) to (6) are mixed and dissolved.
B. Component (2) was added to A and mixed to make a gel ointment.
The gel ointment of Reference Example 9 was excellent in stability over time, and applied to the skin to suppress erythema caused by sunburn and effectively prevent pigmentation.

Reference Example 10 Cream preparation example (formulation) (%)
(1) Polyoxyethylene (40E.O.) monostearate 2.0 (2) Glycerin monostearate (self-emulsifying type) 5.0 (3) Stearic acid 5.0 (4) Behenyl alcohol 0.5 (5 ) Squalane 15.0 (6) Cetyl isooctanoate 5.0 (7) Preservative appropriate amount (8) 1,3-butylene glycol 5.0 (9) Complex salt of L-ascorbic acid derivative * 1 0.2 (10 ) Mokka extract * 2 0.5 (11) Purified water Remaining amount (12) Fragrance Appropriate amount * 1 Produced in the above reference example * 2 Made by Maruzen Pharmaceutical Co., Ltd. (production method)
A. Components (1) to (7) are dissolved by heating at 70 ° C.
B. Ingredients (8) and (11) are heated to 70 ° C.
C. A is added to B, (9), (10) and (12) are mixed and then cooled to obtain a cream.
Reference Example 10 This cream was excellent in stability over time, and when applied to the skin, it became a beautiful skin with no dullness and transparency.

Example 6
Small disposable iontophoresis device 8 ml of an aqueous solution of AP5 lotion manufactured by ITO Co., Ltd. dissolved in 5% weight of sodium ascorbate phosphate powder manufactured by ITO Co., Ltd., which becomes negative ions in an aqueous solution as an active ingredient, ITO Co., Ltd. The mask sheet A was affixed to the face by soaking into a face mask sheet manufactured by the company. Next, ion introduction was performed for 15 minutes from the top of the mask sheet with the following disposable iontophoresis device of the present invention.
The figure below shows a zinc electrode B, which is a zinc paint containing 90% or more of zinc and made by spraying NOXDOL ZINK with a film thickness of 50 μm on a part of the molded body E made of polypropylene. It is in contact with the target site to which the active ingredient of the face is to be introduced through the mask sheet. C is an electrode portion coated with a film thickness of 50 μm by ELECTRODAG SP-029 manufactured by Moritex Co., Ltd., which is a conductive paint containing silver-plated copper fine particles, which is in contact with the finger of the same person's hand . At this time, a voltage of 632 mv was generated between CB between C and B, and the B pole was negatively charged. As a result, negatively ionized ascorbic acid phosphate in the mask sheet in the vicinity of the B electrode can be efficiently and effectively ionized into the facial target skin, and a high effect was observed in improving acne, whitening and wrinkles. Furthermore, the wound healing effect was enhanced by the effect of zinc eluted in a trace amount from the zinc electrode of B. Furthermore, the sterilization effect was recognized in the contact part by Ag ion discharge | released in a trace amount from C electrode.
[Fig. 7]

Example 7
Small Disposable Iontophoretic Patch The following figure is an example of ELECTRODAG SP-029 manufactured by Moritex Co., Ltd., which is a conductive paint in which fine particles of silver-plated copper are blended in advance on a part of the face mask sheet A manufactured by ITO Corporation. A film-like electrode B was adhered by spray coating with a film thickness of 50 μm. The electrode B was connected to the ground C with a conductive wire. The face mask sheet A was soaked with 8 ml of an aqueous solution in which 5% by weight of powder of magnesium ascorbate phosphate manufactured by ITO Co., Ltd., which becomes positive ions in the aqueous solution as an active ingredient. A voltage difference of 313 mV was generated between the face and B due to electricity generated by biological activity or static electricity of the human body. Using this potential difference, magnesium ascorbate phosphate soaked in the face mask sheet A was introduced into the face for 15 minutes.
[Fig. 8]

Example 8
Small disposable ion-introduced patch The following figure is a part of the top face mask sheet A manufactured by ITO Co., Ltd., which is a zinc paint containing 90% or more of zinc in advance. The film-like zinc electrode B was adhered by spraying the coating. During ion introduction, a part of the body was brought into contact with earth C, which is a concrete wall of the building. The face mask sheet A was soaked with 8 ml of an aqueous solution in which 5% by weight of a powder of sodium ascorbate phosphate manufactured by ITO Co., which became negative ions in the aqueous solution as an active ingredient. A voltage difference of 432 mV occurred between the face and B due to electricity generated by ionization of the zinc electrode. Using this potential difference, sodium ascorbate phosphate soaked in the face mask sheet A was introduced into the face for 15 minutes.
[Fig. 9]

Example 9 Small Disposable Iontophoresis Device B and E in FIG. 15 are disk-shaped small mask sheets having a diameter of 1 cm cut from a face mask sheet manufactured by ITO Corporation. On one side of the mask sheet, Zinc electrode A, which is a zinc paint containing 90% or more of zinc, made by Shinshin Co., Ltd. and sprayed with NOxDOL ZINK with a film thickness of 50 μm, is coated on the mask sheet. Has been. On the other disk-shaped mask sheet E having a diameter of 1 cm, silver coated by spraying with a film thickness of 50 μm by ELECTRODAG SP-029 manufactured by Moritex Co., Ltd., which is a conductive paint containing silver-plated copper fine particles. A plated copper electrode D is painted on the mask sheet.
B is impregnated with 0.5 ml of an aqueous solution of AP5 lotion manufactured by ITO Co., Ltd. in which 5% by weight of a powder of sodium ascorbate phosphate manufactured by ITO Co., Ltd., which becomes negative ions as an active ingredient, is impregnated on the face. It is installed on acne lesion C. Further, E is impregnated with 0.5 ml of a 5% by weight tranexamic acid aqueous solution (citrate buffer solution, pH 5) which becomes a positive ion in an aqueous solution as an active ingredient, and is placed on the melasma lesion F on the face. At this time, a voltage of 572 mv was generated between AD between A and D, and the A pole was negatively charged and the D pole was positively charged. As a result, negatively ionized ascorbic acid phosphate in the mask sheet near the A electrode can be efficiently introduced into the acne lesion, and at the same time, positively charged tranexamic acid is effective for the measles lesion F. Introduced in, improved acne and melasma at the same time. When a plurality of AB and DE were installed on the face, a synergistic effect was observed. Furthermore, a 5% aqueous solution of magnesium zinc ascorbate manufactured by ITO Co., Ltd. was blended with tranexamic acid in E because it was found that the molecule was positively charged because magnesium was not completely dissociated in the aqueous solution. However, a synergistic effect was observed in the improvement of melasma. From the DE, Ag ions are eluted, and when AB is applied to the face and DE is applied to the face, an excellent odor control effect is observed, and when DE is applied to the foot, an improvement effect against athlete's foot is observed, When DE was applied to the scalp, an improvement effect against dandruff and kayumi was observed. Furthermore, when a plurality of ABs were applied to the scalp and a plurality of DEs were applied to the side and the foot, a hair growth effect was simultaneously observed in the scalp, and an odor suppression effect was observed in the armpits, while an athlete's foot suppression effect was observed in the foot.
[FIG. 10]
Explanation of figure: B and E are small mask sheets. The zinc electrode A is painted on one B of the mask sheet. On the other mask sheet E, a silver plated copper electrode D is coated on the mask sheet. B is impregnated with 0.5 ml of a 5% by weight aqueous solution of sodium ascorbate that becomes negative ions in the aqueous solution as an active ingredient, and is placed on the acne lesion C on the face. Further, E is impregnated with 0.5 ml of a 5% by weight tranexamic acid aqueous solution (citrate buffer solution, pH 5) which becomes a positive ion in an aqueous solution as an active ingredient, and is placed on the melasma lesion F on the face.

Example 10
Iontophoretic mask sheet Integral Co., Ltd. Skin Image Analysis Counseling System “VISIA” Two-point water-based ink with a 3-cm interval next to the nose on the right face of a 47-year-old adult male with pigmentation After marking with, take a photo of the face with visible light and UV light (black light), import the image data into "VISIA", analyze the image with the included software, and then check the face photo for spots, wrinkles, pores, skin The color homogeneity, the position, quantity and shape of porphyrin, hide-and-seek were identified.
Of these, vitamin C derivatives with the following composition are effective on the right side of an ITO face mask sheet cut in half vertically on the actual scale using the information specifying the position, quantity and shape of the stain as a reference point. The composition contained as a component was printed and used as a face mask A. On the face mask A, the reference point was simultaneously printed with the existing black ink. After printing, it was dried with warm air of 62 ° C. for 3 minutes.
APPS Ascorbic acid palmitate manufactured by Showa Denko Co., Ltd. 3.5 parts Ajisper PB821 (pigment dispersant manufactured by Ajinomoto Fine-Techno Co., Ltd.) 1.2 parts Diethylene glycol diethyl ether 5.3 parts Vinyl resin VYHD (produced by Dow Chemicals) 4.5 parts BYK-361N (acrylic resin manufactured by BYK Chemie) 0.5 parts diethylene glycol methyl ethyl ether 85 parts Similarly, the right face sheet obtained by cutting the ITO face mask sheet vertically in half is coated with silver-plated copper particles in advance. A face mask B was prepared by spraying and painting the periphery of the face mask sheet with a thickness of 50 μm with ELECTRODAG SP-029 manufactured by Moritex Co., Ltd., which is a blended conductive paint, and having a thickness of 5 mm. Similarly, this face mask B was printed with an active ingredient containing fine zinc powder having the following composition on an actual scale using information specifying the position, quantity and shape of the stain. As a result, zinc fine powder was printed on the face mask B at exactly the same position and size as the printed ascorbic acid palmitate printed on the face mask A. The reference point was also printed with the existing black ink. After printing, it was dried with warm air of 62 ° C. for 3 minutes.
Zinc fine powder (average particle size 100 μm) 3.5 parts Azisper PB821 (pigment dispersant manufactured by Ajinomoto Fine Techno Co., Ltd.) 1.2 parts diethylene glycol diethyl ether 5.3 parts Vinyl resin VYHD (vinyl chloride resin manufactured by Dow Chemicals) 4 .5 parts BYK-361N (acrylic resin manufactured by BYK Chemie) 0.5 parts diethylene glycol methyl ethyl ether 85 parts Next, a 1% NaCl solution is fogged from both sides so that the reference points of face masks A and B coincide with each other. A double AB face mask was brought into contact with the face so that the face mask A was in contact with the face by spraying in the shape of the face and the reference point of the face mask and the reference point of the face were overlapped. Ions were introduced by removing the trapped air bubble part by lightly acupressure and maintaining for 15 minutes.
[FIG. 11]

[Figure 1]
A represents a body surface such as a human body or a living organism. F is a target site such as a lesion where the drug is to penetrate. E represents a solvent containing an effective component capable of being electrophoresed and a carrier or a molded article holding the solvent. C and D are electrodes installed at different locations on the body surface. B represents a conductive line connecting two electrodes. G is a circuit composed of conductive wires or power storage devices such as relays and capacitors, and rectifiers such as diodes.
[Figure 2]
A represents a body surface such as a human body or a living organism. F is a target site such as a lesion where the drug is to penetrate. E represents a solvent containing an effective component capable of being electrophoresed and a carrier or a molded article holding the solvent. C is an electrode installed at a different location on the body surface. B represents a conductive line. G is a circuit composed of conductive wires or power storage devices such as relays and capacitors, and rectifiers such as diodes. D represents ground.
[Figure 3]
A represents a body surface such as a human body or a living organism. G is a target site such as a lesion where the drug is to penetrate. E and F represent a solvent containing an effective component capable of being electrophoresed and a carrier or a molded article holding the solvent. C and D are electrodes.
[Fig. 4]
A represents a body surface such as a human body or a living organism. G is a target site such as a lesion where the drug is to penetrate. E and F represent a solvent containing an effective component capable of being electrophoresed and a carrier or a molded product holding the solvent. C and D are electrodes installed at different locations on the body surface. B represents a conductive line. G is a circuit composed of conductive wires or power storage devices such as relays and capacitors, and rectifiers such as diodes.
[Figure 5]
A represents a body surface such as a human body or a living organism. E represents a solvent containing an effective component capable of being electrophoresed and a carrier or a molded article holding the solvent. C, C ′, D and D ′ are electrodes installed at different locations on the body surface. B represents a conductive line. G is a circuit composed of conductive wires or power storage devices such as relays and capacitors, and rectifiers such as diodes.
[Fig. 6]
A is a conductive electrode such as zinc. B is a copper electrode. E is a cross section of the thread for coupling to the cosmetic container.
[Fig. 7]
A zinc electrode B is in contact with the face through a mask sheet on a part of the molded body E made of polypropylene. C is an electrode part of silver-plated copper and is in contact with the finger of the hand.
[Fig. 8]
A silver-plated copper electrode B was adhered to a part of the face mask sheet A soaked with a 5% magnesium ascorbate aqueous solution. The electrode B was connected to the ground C with a conductive wire.
[Fig. 9]
A zinc electrode B was adhered to a part of the face mask sheet A soaked with a 5% magnesium ascorbate aqueous solution. During ion introduction, a part of the body (hand) was brought into contact with earth C, which is a concrete wall of the building.
[FIG. 10]
B and E are disk-shaped small mask sheets. A zinc electrode A is coated on a mask sheet on B containing 5% by weight aqueous solution of sodium ascorbate phosphate. On E, a silver plated copper electrode D is painted on a mask sheet. C is an acne lesion. Further, E has a mask sheet impregnated with a 5% by weight tranexamic acid aqueous solution as an active ingredient placed on the melasma lesion F on the face.
[FIG. 11]
Description of Figures: A: Face mask A, B: Face masks B and C are face masks superimposed on the face, E: Reference points printed on the face mask A, F: Reference points printed on the face mask B, G: Reference point applied with water-based ink on subject's face, H: Location where ascorbic acid palmitate was correctly printed, I: Location where zinc fine particles were printed correctly, D: Silver plated copper fine particles , J: Actual spot on the subject's face

Claims (4)

  Electronically record and capture an image of a subject, electronically process the image to identify one or more locations with a specific tone or absorption wavelength, and map one or more to the mapped position A method for producing a sheet for introducing a single-layer or multiple-layer active ingredient into a subject, wherein a solution containing a plurality of active ingredients is accurately printed on a mask sheet in μm units using a printing apparatus. Electronically record and capture an image of a subject, electronically process the image to identify one or more locations with a specific tone or absorption wavelength, and map one or more to the mapped position As a single-layer or multi-layer sheet obtained by printing a solution containing a plurality of components on a mask sheet accurately in units of μm using a printing apparatus, the components are different and the printing positions are the same. A plurality of sheets are produced, and a plurality of the sheets are accurately stacked so that the positions of the prints coincide with each other, thereby causing a chemical reaction with the components of the plurality of sheets, and generating or A method for producing a sheet for introducing an active ingredient into a subject, wherein the changed active ingredient is accurately arranged on a mask sheet in units of μm.   Electronically record and capture an image of a subject, electronically process the image to identify one or more locations with a specific tone or absorption wavelength, and map one or more to the mapped position A method for producing a sheet for introducing a single-layer or multiple-layer active ingredient into a subject, wherein a liquid solvent containing a plurality of conductive substances is accurately printed on a mask sheet in μm units using a printing apparatus. A single or multi-layer sheet obtained by accurately printing a solution containing a single component or a plurality of components on a mask sheet in units of μm, and using a plurality of sheets having different components and the same printing position. The above-described sheets are accurately stacked so that the printing positions coincide with each other, thereby causing a chemical reaction with the components of the plurality of sheets, and an active ingredient generated or changed depending on the result of the reaction, in μm units. A sheet for introducing the active ingredient into the subject accurately placed on the mask sheet.