JP5311060B2 - 固形腫瘍の治療のためのＥｐｈＡ３抗体 - Google Patents

固形腫瘍の治療のためのＥｐｈＡ３抗体 Download PDF

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JP5311060B2
JP5311060B2 JP2009552761A JP2009552761A JP5311060B2 JP 5311060 B2 JP5311060 B2 JP 5311060B2 JP 2009552761 A JP2009552761 A JP 2009552761A JP 2009552761 A JP2009552761 A JP 2009552761A JP 5311060 B2 JP5311060 B2 JP 5311060B2
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epha3
antibody
pharmaceutical composition
tumor
composition according
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JP2010520290A (ja
JP2010520290A5 (Direct
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マルティン ラックマン
アンドリュー マーク スコット
クリストファー アール． ベッビングトン
ジェフリー ティー． ヤーラントン
キャサリン トー
カーメリナ ムローン
Original Assignee
カロバイオス ファーマシューティカルズ インコーポレイティッド
モナシュ ユニバーシティー
ラディック インスティテュート フォー キャンサー リサーチ リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
    • A61K47/6849—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A61K51/1033—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants against receptors for cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Optics & Photonics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2009552761A 2007-03-08 2008-03-10 固形腫瘍の治療のためのＥｐｈＡ３抗体 Active JP5311060B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US89384807P 2007-03-08 2007-03-08
US60/893,848 2007-03-08
PCT/US2008/003149 WO2008112192A2 (en) 2007-03-08 2008-03-10 Epha3 antibodies for the treatment of solid tumors

Publications (3)

Publication Number Publication Date
JP2010520290A JP2010520290A (ja) 2010-06-10
JP2010520290A5 JP2010520290A5 (Direct) 2011-04-21
JP5311060B2 true JP5311060B2 (ja) 2013-10-09

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JP2009552761A Active JP5311060B2 (ja) 2007-03-08 2008-03-10 固形腫瘍の治療のためのＥｐｈＡ３抗体

Country Status (13)

Country Link
US (1) US8637016B2 (Direct)
EP (2) EP2136838B1 (Direct)
JP (1) JP5311060B2 (Direct)
CN (1) CN101641115B (Direct)
AU (1) AU2008226905C1 (Direct)
CA (1) CA2679986C (Direct)
DK (1) DK3199180T3 (Direct)
ES (1) ES2910298T3 (Direct)
IL (1) IL200764A (Direct)
NZ (1) NZ579478A (Direct)
PL (1) PL3199180T3 (Direct)
PT (1) PT3199180T (Direct)
WO (1) WO2008112192A2 (Direct)

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AU2008287426B2 (en) 2007-08-10 2014-06-26 Protelica, Inc. Universal fibronectin type III binding-domain libraries
US8834870B2 (en) * 2009-03-06 2014-09-16 Kalobios Pharmaceuticals, Inc. Treatment of leukemias and chronic myeloproliferative diseases with antibodies to EphA3
WO2011053465A1 (en) * 2009-10-14 2011-05-05 Kalobios Pharmaceuticals, Inc. Antibodies to epha3
WO2011123819A2 (en) * 2010-04-01 2011-10-06 Kalobios Pharmaceuticals, Inc. Epha3 antibodies for the treatment of multiple myeloma
WO2011160132A2 (en) * 2010-06-18 2011-12-22 Kalobios Pharmaceuticals, Inc. Detection of epha3 as a marker of the presence of a solid tumor
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JP6400470B2 (ja) 2011-05-16 2018-10-03 ジェネロン（シャンハイ）コーポレイション リミテッド 多重特異性Ｆａｂ融合タンパク質および使用法
JP2014527054A (ja) * 2011-08-12 2014-10-09 カロバイオス ファーマシューティカルズ インコーポレイティッド 骨髄内の異常血管系上に発現したＥｐｈＡ３を標的とすることによる、血液増殖性疾患を処置する方法
CA2930243A1 (en) 2013-11-11 2015-05-14 Wake Forest University Health Sciences Epha3 and multi-valent targeting of tumors
US10870701B2 (en) 2016-03-15 2020-12-22 Generon (Shanghai) Corporation Ltd. Multispecific fab fusion proteins and use thereof
EP3847196A4 (en) 2018-09-07 2023-01-04 ITabMed (HK) Limited BISPECIFIC ANTIGEN BINDING PROTEINS AND USES THEREOF
IL291937A (en) * 2019-10-09 2022-06-01 Council Queensland Inst Medical Res Targeting epha3 and uses thereof

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Also Published As

Publication number Publication date
AU2008226905A1 (en) 2008-09-18
PL3199180T3 (pl) 2022-08-08
EP3199180B1 (en) 2022-01-05
AU2008226905C1 (en) 2014-11-06
IL200764A (en) 2017-01-31
EP2136838A2 (en) 2009-12-30
CN101641115A (zh) 2010-02-03
US8637016B2 (en) 2014-01-28
ES2910298T3 (es) 2022-05-12
WO2008112192A2 (en) 2008-09-18
AU2008226905B2 (en) 2014-05-01
EP2136838B1 (en) 2017-03-08
JP2010520290A (ja) 2010-06-10
WO2008112192A3 (en) 2008-11-13
IL200764A0 (en) 2010-05-17
PT3199180T (pt) 2022-04-01
CN101641115B (zh) 2013-04-24
CA2679986A1 (en) 2008-09-18
NZ579478A (en) 2012-08-31
EP3199180A1 (en) 2017-08-02
DK3199180T3 (da) 2022-03-21
CA2679986C (en) 2018-03-06
US20080286272A1 (en) 2008-11-20

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