JP5301449B2 - 有機アルセノキシド化合物およびその使用 - Google Patents

有機アルセノキシド化合物およびその使用 Download PDF

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JP5301449B2
JP5301449B2 JP2009533614A JP2009533614A JP5301449B2 JP 5301449 B2 JP5301449 B2 JP 5301449B2 JP 2009533614 A JP2009533614 A JP 2009533614A JP 2009533614 A JP2009533614 A JP 2009533614A JP 5301449 B2 JP5301449 B2 JP 5301449B2
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hydrogen
compound
methyl
alkyl
formula
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Japanese (ja)
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JP2010508245A (ja
JP2010508245A5 (https=
Inventor
フィリップ ジョン ホッグ
ピエール ディルダ
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ニューサウス イノベイションズ ピーティーワイ リミテッド
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Priority claimed from AU2006906220A external-priority patent/AU2006906220A0/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66—Arsenic compounds
    • C07F9/70—Organo-arsenic compounds
    • C07F9/74—Aromatic compounds
    • C07F9/76—Aromatic compounds containing hydroxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2009533614A 2006-11-01 2007-11-01 有機アルセノキシド化合物およびその使用 Active JP5301449B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2006906220 2006-11-01
AU2006906220A AU2006906220A0 (en) 2006-11-01 Arsenoxide compounds and use thereof
PCT/AU2007/001676 WO2008052279A1 (en) 2006-11-01 2007-11-01 Organo-arsenoxide compounds and use thereof

Publications (3)

Publication Number Publication Date
JP2010508245A JP2010508245A (ja) 2010-03-18
JP2010508245A5 JP2010508245A5 (https=) 2010-12-16
JP5301449B2 true JP5301449B2 (ja) 2013-09-25

Family

ID=39343707

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2009533614A Active JP5301449B2 (ja) 2006-11-01 2007-11-01 有機アルセノキシド化合物およびその使用

Country Status (8)

Country Link
US (2) US8268883B2 (https=)
EP (1) EP2069371B1 (https=)
JP (1) JP5301449B2 (https=)
CN (1) CN101595115B (https=)
AU (1) AU2007314076B2 (https=)
CA (1) CA2668010C (https=)
ES (1) ES2411094T3 (https=)
WO (1) WO2008052279A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6911471B2 (en) 2002-01-07 2005-06-28 The Texas A&M University System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
CA2504935C (en) 2002-11-07 2012-04-10 Newsouth Innovations Pty Limited Induction of the mitochondrial permeability transition
WO2009043114A1 (en) * 2007-10-04 2009-04-09 Newsouth Innovations Pty Limited Arsenoxide compound and method of use
TWI539493B (zh) 2010-03-08 2016-06-21 黛納羅伊有限責任公司 用於摻雜具有分子單層之矽基材之方法及組合物
US8853438B2 (en) * 2012-11-05 2014-10-07 Dynaloy, Llc Formulations of solutions and processes for forming a substrate including an arsenic dopant
WO2016201481A1 (en) * 2015-06-15 2016-12-22 Newsouth Innovations Pty Limited Pharmaceutical combinations of organo-arsenoxide compounds and mtor inhibitors
EP3953338A4 (en) 2019-04-12 2023-06-07 Centenary Institute Of Cancer Medicine And Cell Biology CONJUGATES AND THEIR USE AS IMAGING AGENTS

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2370092A (en) 1942-05-04 1945-02-20 Parke Davis & Co Organic amine derivatives and method of obtaining same
US2409291A (en) 1942-05-19 1946-10-15 Squibb & Sons Inc Chemotherapeutic sulfanilamide derivatives
US2465308A (en) 1946-11-27 1949-03-22 Hoffmann La Roche Arsenoso compounds and method of preparation
US2664432A (en) 1947-01-28 1953-12-29 Ernst A H Friedheim Heterocyclic metal and sulfur organic compounds
US2553515A (en) 1948-12-11 1951-05-15 Hoffmann La Roche N-(p-arsenoso-benzyl)-urea
US2951766A (en) 1957-07-15 1960-09-06 Le Roy A White Antiseptic plastic
BE786573A (fr) * 1971-07-20 1973-01-22 Hoechst Ag Medicament a base de composes arsenicaux organiques et de derives du benzimidazole
FR2640269B1 (fr) 1988-12-13 1991-03-15 Maes Ludo Composes organometalliques, leurs modes de preparation et compositions pharmaceutiques les contenant
US5270196A (en) 1989-10-20 1993-12-14 Bristol-Myers Squibb Company Arylsulfatase from streptomyces
FR2684382B1 (fr) 1991-12-02 1994-10-21 Rhone Merieux Medicaments et preparations pures de dichlorhydrate de melarsomine, leur procede d'obtention et produits intermediaires obtenus.
EP0981344A1 (en) 1997-05-14 2000-03-01 The University of New Mexico Inhibition of cell surface protein disulfide isomerase
JP2001519366A (ja) 1997-10-15 2001-10-23 ポーラクス バイオファーマシュティカルズ，インコーポレーテッド ヒ素化合物を用いた、原発性および転移性の腫瘍性疾患を治療するための組成物および方法
CN1233476A (zh) 1998-04-24 1999-11-03 陆道培 治疗急性白血病的药物及其制备方法
CA2349444A1 (en) 1998-11-03 2000-05-11 Mitokor Production of adenine nucleotide translocator (ant), novel ant ligands and screening assays therefor
US6191123B1 (en) 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
WO2000079274A2 (en) 1999-06-22 2000-12-28 Mitokor Methods for assaying subcellular conditions using energy transfer
AUPQ296799A0 (en) * 1999-09-20 1999-10-14 Unisearch Limited A cell-membrane impermeable trivalent organoarsenical derivative and use thereof
AUPR379801A0 (en) * 2001-03-19 2001-04-12 Unisearch Limited Use of a substantially cell membrane impermeable compound for treating arthritis
AUPR598901A0 (en) * 2001-06-28 2001-07-19 Unisearch Limited Inhibition of angiogenesis by targeting protein tyrosine phosphatases
AUPR874601A0 (en) * 2001-11-08 2001-11-29 Unisearch Limited Selective targeting of apoptotic cells
US6911471B2 (en) * 2002-01-07 2005-06-28 The Texas A&M University System S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer
CA2504935C (en) * 2002-11-07 2012-04-10 Newsouth Innovations Pty Limited Induction of the mitochondrial permeability transition
AU2002952526A0 (en) * 2002-11-07 2002-11-21 Unisearch Limited Induction of the mitochondrial permeability transition
WO2009043114A1 (en) * 2007-10-04 2009-04-09 Newsouth Innovations Pty Limited Arsenoxide compound and method of use

Also Published As

Publication number Publication date
US9765101B2 (en) 2017-09-19
CN101595115B (zh) 2012-07-18
EP2069371B1 (en) 2013-03-13
JP2010508245A (ja) 2010-03-18
AU2007314076B2 (en) 2012-07-19
CN101595115A (zh) 2009-12-02
CA2668010C (en) 2015-03-24
AU2007314076A1 (en) 2008-05-08
WO2008052279A1 (en) 2008-05-08
CA2668010A1 (en) 2008-05-08
US20130041027A1 (en) 2013-02-14
US20100041749A1 (en) 2010-02-18
EP2069371A4 (en) 2010-02-10
US8268883B2 (en) 2012-09-18
ES2411094T3 (es) 2013-07-04
EP2069371A1 (en) 2009-06-17

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