JP5280801B2 - Dental composition - Google Patents
Dental composition Download PDFInfo
- Publication number
- JP5280801B2 JP5280801B2 JP2008279157A JP2008279157A JP5280801B2 JP 5280801 B2 JP5280801 B2 JP 5280801B2 JP 2008279157 A JP2008279157 A JP 2008279157A JP 2008279157 A JP2008279157 A JP 2008279157A JP 5280801 B2 JP5280801 B2 JP 5280801B2
- Authority
- JP
- Japan
- Prior art keywords
- eugenol
- zinc oxide
- agent
- dental composition
- main agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Description
この発明は、例えば歯牙根管充填材、仮封材、歯髄鎮痛消炎剤、覆髄剤等として用いられる歯科用組成物に関する。 The present invention relates to a dental composition used as, for example, a tooth root canal filling material, a temporary sealing material, a pulp analgesic / antiinflammatory agent, a pulp capping agent, and the like.
酸化亜鉛ユージノールセメントは、歯科用の例えば歯牙根管充填材、仮封材、歯髄鎮痛消炎剤、覆髄剤等として用いられている。例えば歯牙根管充填用の酸化亜鉛ユージノールセメントとしては、酸化亜鉛及びクロルヘキシジン塩を含有してなる第１剤と、ユージノールを主成分とする第２剤とからなり、充填時に両方を混練して用いる酸化亜鉛ユージノールセメントが公知である（特許文献１参照）。含有成分のユージノールにより殺菌、鎮痛作用等の薬理効果が得られる。
ところで、従来より、ユージノールは組織為害性を有するという報告がなされている。本発明者らの研究により、酸化亜鉛ユージノールセメントから遊離したユージノールの含有濃度が高い場合には組織為害性を呈しやすくなることが判った。 By the way, conventionally, it has been reported that Eugenol has a tissue harmful effect. According to the study by the present inventors, it has been found that when the concentration of eugenol released from the zinc oxide eugenol cement is high, the tissue damage is likely to be exhibited.
そこで、ユージノールの含有比率を低減せしめた処方を種々検討したが、単にユージノールを減らしただけでは、組成物としての操作性が悪くなるし、硬化も十分に行わせることができないという問題があることが判明した。 Therefore, various prescriptions with a reduced content ratio of eugenol were studied, but simply reducing eugenol has a problem that the operability as a composition is deteriorated and curing cannot be performed sufficiently. There was found.
この発明は、かかる技術的背景に鑑みてなされたものであって、組織為害性を低減することができ、良好な操作性が得られると共に、十分に硬化させることができ、且つ適度な硬化時間を確保できる歯科用組成物を提供することを目的とする。 The present invention has been made in view of such a technical background, and can reduce tissue damage, obtain good operability, can be sufficiently cured, and has an appropriate curing time. An object of the present invention is to provide a dental composition capable of ensuring the above.
前記目的を達成するために、本発明は以下の手段を提供する。 In order to achieve the above object, the present invention provides the following means.
［１］主剤と硬化剤とからなり、主剤と硬化剤とを混合することによって硬化する歯科用組成物であって、
前記主剤は、ユージノール、オレイン酸及びイソステアリン酸を含有してなり、
前記硬化剤は、酸化亜鉛を含有してなり、
これらの配合割合が、ユージノール３μＬ当たりに対し、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇの配合割合であることを特徴とする歯科用組成物。
[1] A dental composition comprising a main agent and a hardener, which is hardened by mixing the main agent and the hardener,
The main agent comprises eugenol, oleic acid and isostearic acid,
The curing agent contains zinc oxide,
A dental composition characterized in that these blending ratios are blending ratios of oleic acid 10 to 16.5 μL, isostearic acid 0.5 to 7 μL, and zinc oxide 10 to 25 mg per 3 μL of Eugenol.
［２］主剤と硬化剤とからなり、主剤と硬化剤とを混合することによって硬化する歯科用組成物であって、
前記主剤は、ユージノールを含有してなり、
前記硬化剤は、酸化亜鉛を含有してなり、
オレイン酸が、前記主剤及び前記硬化剤のうちの少なくともいずれか一方に含有せしめられ、
イソステアリン酸が、前記主剤及び前記硬化剤のうちの少なくともいずれか一方に含有せしめられ、
これらの配合割合が、ユージノール３μＬ当たりに対し、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇの配合割合であることを特徴とする歯科用組成物。
[2] A dental composition comprising a main agent and a hardener, which is hardened by mixing the main agent and the hardener,
The main agent contains eugenol,
The curing agent contains zinc oxide,
Oleic acid is contained in at least one of the main agent and the curing agent,
Isostearic acid is contained in at least one of the main agent and the curing agent,
A dental composition characterized in that these blending ratios are blending ratios of oleic acid 10 to 16.5 μL, isostearic acid 0.5 to 7 μL, and zinc oxide 10 to 25 mg per 3 μL of Eugenol.
［３］ユージノール、オレイン酸、イソステアリン酸及び酸化亜鉛を含有してなり、
これらの配合割合が、ユージノール３μＬ当たりに対し、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇの配合割合であることを特徴とする歯科用組成物。
[3] containing eugenol, oleic acid, isostearic acid and zinc oxide,
A dental composition characterized in that these blending ratios are blending ratios of oleic acid 10 to 16.5 μL, isostearic acid 0.5 to 7 μL, and zinc oxide 10 to 25 mg per 3 μL of Eugenol.
［１］、［２］及び［３］の発明では、ユージノールの含有率が従来よりも小さいので、組織為害性が殆ど認められないものとなる。また、ユージノールを減らしただけでは、操作性が悪くなるし、十分な硬化も行われ難くなるのであるが、本発明ではその分オレイン酸を上記特定割合含有せしめているので、良好な操作性が得られると共に十分に硬化させることができ、また適度な粘稠度も確保できる。更に、本発明では、イソステアリン酸を上記特定割合含有せしめているので、硬化時間を遅延させることができ、これにより適度な硬化時間（例えば約１時間程度の硬化時間）を確保できる。例えば歯科治療等において十分な操作時間を確保することができる。また、本発明の歯科用組成物の硬化物は、封鎖性に非常に優れているという利点がある。 In the inventions [1], [2] and [3], since the content of eugenol is smaller than that of the conventional one, the structural damage is hardly recognized. In addition, the operability is deteriorated only by reducing Eugenol, and sufficient curing is difficult to be performed, but in the present invention, since the oleic acid is contained in the above-mentioned proportion, the good operability is obtained. In addition to being obtained, it can be cured sufficiently, and an appropriate consistency can be secured. Furthermore, in the present invention, since the isostearic acid is contained in the above-mentioned specific ratio, the curing time can be delayed, and an appropriate curing time (for example, a curing time of about 1 hour) can be secured. For example, sufficient operation time can be ensured in dental treatment or the like. Moreover, the hardened | cured material of the dental composition of this invention has the advantage that it is very excellent in sealing property.
この発明に係る歯科用組成物は、ユージノール、オレイン酸、イソステアリン酸及び酸化亜鉛を含有してなり、これらの配合割合が、ユージノール３μＬ当たりに対し（ユージノールの体積を３μＬに換算した時に）、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇの配合割合であることを特徴とする。 The dental composition according to the present invention contains eugenol, oleic acid, isostearic acid, and zinc oxide, and the blending ratio thereof is 3 μL of eugenol (when the volume of eugenol is converted to 3 μL). It is characterized by being a blending ratio of 10 to 16.5 μL of acid, 0.5 to 7 μL of isostearic acid, and 10 to 25 mg of zinc oxide.
前記歯科用組成物の好適な構成は、主剤と硬化剤とからなり、主剤と硬化剤とを混合することによって硬化する歯科用組成物であって、前記主剤は、ユージノールを含有してなり、前記硬化剤は、酸化亜鉛を含有してなり、オレイン酸が、前記主剤及び前記硬化剤のうちの少なくともいずれか一方に含有せしめられ、イソステアリン酸が、前記主剤及び前記硬化剤のうちの少なくともいずれか一方に含有せしめられ、これらの配合割合が、ユージノール３μＬ当たりに対し（ユージノールの体積を３μＬに換算した時に）、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇの配合割合である構成である。 A preferred configuration of the dental composition is a dental composition comprising a main agent and a hardener, which is hardened by mixing the main agent and the hardener, the main agent containing eugenol, The curing agent contains zinc oxide, oleic acid is contained in at least one of the main agent and the curing agent, and isostearic acid is at least one of the main agent and the curing agent. These are contained in either of these, and the blending ratio thereof is 10 to 16.5 μL of oleic acid, 0.5 to 7 μL of isostearic acid, 10 to 10 of zinc oxide with respect to 3 μL of Eugenol (when the volume of Eugenol is converted to 3 μL). The composition is a blending ratio of 25 mg.
中でも、前記歯科用組成物は、主剤と硬化剤とからなり、主剤と硬化剤とを混合することによって硬化する歯科用組成物であって、前記主剤は、ユージノール、オレイン酸及びイソステアリン酸を含有してなり、前記硬化剤は、酸化亜鉛を含有してなり、これらの配合割合が、ユージノール３μＬ当たりに対し（ユージノールの体積を３μＬに換算した時に）、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇである構成が特に好適である。 Among them, the dental composition comprises a main agent and a hardener, and is a dental composition that hardens by mixing the main agent and a hardener, and the main agent contains eugenol, oleic acid and isostearic acid. Thus, the curing agent contains zinc oxide, and the blending ratio thereof is 10 to 16.5 μL of oleic acid and isostearic acid with respect to 3 μL of Eugenol (when the volume of Eugenol is converted to 3 μL). A configuration of 0.5 to 7 μL and zinc oxide of 10 to 25 mg is particularly preferable.
前記ユージノールは、鎮痛消炎作用や静菌作用を発揮するものであり、硬化剤である酸化亜鉛とキレート反応することにより硬化する。ユージノールが高濃度では、組織刺激性があり、歯髄に対する為害性が懸念されることから、本発明では、上記特定の配合割合に設定してユージノール含有率を小さくすることにより、組織為害性が殆ど認められないものとなったものである。前記ユージノールとしては、丁字油より抽出された精油が一般的に用いられる。前記ユージノールの比重は１．０６６ｇ／ｍＬである。 Eugenol exhibits analgesic / anti-inflammatory and bacteriostatic effects, and is cured by chelating reaction with zinc oxide as a curing agent. At high concentrations of eugenol, there is tissue irritation and there is concern about harmfulness to the dental pulp. Therefore, in the present invention, the eugenol content is reduced by setting the above-mentioned specific blending ratio, so that there is almost no tissue damage. It was not allowed. As the Eugenol, an essential oil extracted from clove oil is generally used. The specific gravity of Eugenol is 1.066 g / mL.
前記オレイン酸は、上記特定割合含有せしめることで、良好な操作性を確保できるし、十分に硬化させることができ、また適度な粘稠度も付与できる。オレイン酸の比重は０．８９ｇ／ｍＬである。 When the oleic acid is contained in the specific ratio, good operability can be secured, it can be sufficiently cured, and an appropriate consistency can be imparted. The specific gravity of oleic acid is 0.89 g / mL.
前記イソステアリン酸は、上記特定割合含有せしめることで、他の特性に影響を及ぼすことなく、硬化時間を遅延させることができ、これにより適度な硬化時間（例えば約３０分〜約１２０分程度の硬化時間）を確保できる。前記イソステアリン酸の比重は０．８７８ｇ／ｍＬである。 The isostearic acid can be included in the above-mentioned specific proportion to delay the curing time without affecting other characteristics, thereby allowing an appropriate curing time (for example, about 30 minutes to about 120 minutes). Time). The specific gravity of the isostearic acid is 0.878 g / mL.
しかして、本発明において、必須成分（４成分）の配合割合は、ユージノール３μＬ当たりに対し、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇに設定される。 Thus, in the present invention, the blending ratio of the essential components (four components) is set to 10 to 16.5 μL of oleic acid, 0.5 to 7 μL of isostearic acid, and 10 to 25 mg of zinc oxide per 3 μL of Eugenol.
オレイン酸の配合割合が上記下限より小さくなると、操作性が悪くなるし、硬化も十分に行わせることができない。また、オレイン酸の配合割合が上記上限より大きくなると、相対的にユージノールの含有率が低下して鎮痛消炎作用や静菌作用が十分に得られなくなる。 When the blending ratio of oleic acid is smaller than the above lower limit, operability is deteriorated and curing cannot be performed sufficiently. Moreover, when the blending ratio of oleic acid is larger than the above upper limit, the content of eugenol is relatively lowered, and the analgesic / anti-inflammatory action and bacteriostatic action cannot be sufficiently obtained.
また、イソステアリン酸の配合割合が上記下限より小さくなると、硬化時間を遅延させることが不十分となり、適度な硬化時間（例えば約３０分〜約１２０分程度の硬化時間）を確保することができない。一方、イソステアリン酸の配合割合が上記上限より大きくなると、硬化時間が遅くなり過ぎて、実用に適さないものとなる。 On the other hand, if the blending ratio of isostearic acid is smaller than the above lower limit, it is insufficient to delay the curing time, and an appropriate curing time (for example, a curing time of about 30 minutes to about 120 minutes) cannot be ensured. On the other hand, if the blending ratio of isostearic acid is larger than the above upper limit, the curing time becomes too slow and it is not suitable for practical use.
また、酸化亜鉛の配合割合が上記下限より小さくなると、十分な硬化を行わせることができない。一方、酸化亜鉛の配合割合が上記上限より大きくなると、相対的にユージノールの含有率が低下して鎮痛消炎作用や静菌作用が十分に得られなくなる。 Moreover, when the compounding ratio of zinc oxide is smaller than the above lower limit, sufficient curing cannot be performed. On the other hand, when the blending ratio of zinc oxide is larger than the above upper limit, the content of eugenol is relatively lowered, and the analgesic / anti-inflammatory action and bacteriostatic action cannot be sufficiently obtained.
なお、前記主剤には、この発明の効果を阻害しない範囲で、ユージノール以外の他の成分を含有せしめても良い。 In addition, you may make the said main ingredient contain other components other than eugenol in the range which does not inhibit the effect of this invention.
また、前記硬化剤には、この発明の効果を阻害しない範囲で、酸化亜鉛以外の他の成分を含有せしめても良い。例えば、ロジン、硫酸バリウム、炭酸ビスマス等を含有せしめても良い。 Moreover, you may make the said hardening | curing agent contain components other than zinc oxide in the range which does not inhibit the effect of this invention. For example, rosin, barium sulfate, bismuth carbonate and the like may be included.
また、前記主剤の性状としては、液状、ペースト状、固形状等のいずれであっても良い。また、前記硬化剤の性状としては、液状、ペースト状、固形状等のいずれであっても良い。 Further, the properties of the main agent may be any of liquid, paste, solid and the like. Further, the properties of the curing agent may be any of liquid, paste, solid and the like.
しかして、前記主剤と前記硬化剤とを混合することによって歯科用組成物を適度な硬化時間（例えば約３０分〜約１２０分程度の硬化時間）で硬化させることができる。上記混合操作としては、混練（練和）するのが好ましく、好適な混練時間は２０〜４０秒である。 Thus, the dental composition can be cured with an appropriate curing time (for example, a curing time of about 30 minutes to about 120 minutes) by mixing the main agent and the curing agent. The mixing operation is preferably kneading (kneading), and a suitable kneading time is 20 to 40 seconds.
次に、この発明の具体的実施例について説明するが、本発明はこれら実施例のものに特に限定されるものではない。 Next, specific examples of the present invention will be described, but the present invention is not particularly limited to these examples.
＜実施例１＞
ユージノール３μＬ、オレイン酸１６μＬ及びイソステアリン酸１μＬを混合して主剤（液剤）を得た。また、酸化亜鉛１６ｍｇ、ロジン１６ｍｇ、硫酸バリウム４ｍｇ及び炭酸ビスマス４ｍｇを混合して硬化剤（固形剤）を得た。次に、前記主剤と前記硬化剤とを金属スパチュラを用いて３０秒間混練（練和）して混練物（歯科用組成物）を得た。
<Example 1>
Eugenol (3 μL), oleic acid (16 μL) and isostearic acid (1 μL) were mixed to obtain a main agent (solution). Further, 16 mg of zinc oxide, 16 mg of rosin, 4 mg of barium sulfate and 4 mg of bismuth carbonate were mixed to obtain a curing agent (solid agent). Next, the main agent and the curing agent were kneaded (kneaded) for 30 seconds using a metal spatula to obtain a kneaded product (dental composition).
＜実施例２＞
ユージノール３μＬ、オレイン酸１３μＬ及びイソステアリン酸４μＬを混合して主剤を得た。また、酸化亜鉛１６ｍｇ、ロジン１６ｍｇ、硫酸バリウム４ｍｇ及び炭酸ビスマス４ｍｇを混合して硬化剤（固形剤）を得た。次に、前記主剤と前記硬化剤とを金属スパチュラを用いて３０秒間混練（練和）して混練物（歯科用組成物）を得た。
<Example 2>
Eugenol 3 μL, oleic acid 13 μL and isostearic acid 4 μL were mixed to obtain a main agent. Further, 16 mg of zinc oxide, 16 mg of rosin, 4 mg of barium sulfate and 4 mg of bismuth carbonate were mixed to obtain a curing agent (solid agent). Next, the main agent and the curing agent were kneaded (kneaded) for 30 seconds using a metal spatula to obtain a kneaded product (dental composition).
＜実施例３＞
ユージノール３μＬ、オレイン酸１１μＬ及びイソステアリン酸６μＬを混合して主剤を得た。また、酸化亜鉛１６ｍｇ、ロジン１６ｍｇ、硫酸バリウム４ｍｇ及び炭酸ビスマス４ｍｇを混合して硬化剤（固形剤）を得た。次に、前記主剤と前記硬化剤とを金属スパチュラを用いて３０秒間混練（練和）して混練物（歯科用組成物）を得た。
<Example 3>
Eugenol 3 μL, oleic acid 11 μL and isostearic acid 6 μL were mixed to obtain a main agent. Further, 16 mg of zinc oxide, 16 mg of rosin, 4 mg of barium sulfate and 4 mg of bismuth carbonate were mixed to obtain a curing agent (solid agent). Next, the main agent and the curing agent were kneaded (kneaded) for 30 seconds using a metal spatula to obtain a kneaded product (dental composition).
＜比較例１＞
ユージノール３μＬ及びオレイン酸１７μＬを混合して主剤を得た。また、酸化亜鉛１６ｍｇ、ロジン１６ｍｇ、硫酸バリウム４ｍｇ及び炭酸ビスマス４ｍｇを混合して硬化剤（固形剤）を得た。次に、前記主剤と前記硬化剤とを金属スパチュラを用いて３０秒間混練（練和）して混練物（歯科用組成物）を得た。
<Comparative Example 1>
Eugenol 3 μL and oleic acid 17 μL were mixed to obtain a main agent. Further, 16 mg of zinc oxide, 16 mg of rosin, 4 mg of barium sulfate and 4 mg of bismuth carbonate were mixed to obtain a curing agent (solid agent). Next, the main agent and the curing agent were kneaded (kneaded) for 30 seconds using a metal spatula to obtain a kneaded product (dental composition).
＜比較例２＞
ユージノール３μＬ、オレイン酸９μＬ及びイソステアリン酸８μＬを混合して主剤を得た。また、酸化亜鉛１６ｍｇ、ロジン１６ｍｇ、硫酸バリウム４ｍｇ及び炭酸ビスマス４ｍｇを混合して硬化剤（固形剤）を得た。次に、前記主剤と前記硬化剤とを金属スパチュラを用いて３０秒間混練（練和）して混練物（歯科用組成物）を得た。
<Comparative example 2>
Eugenol 3 μL, oleic acid 9 μL and isostearic acid 8 μL were mixed to obtain a main agent. Further, 16 mg of zinc oxide, 16 mg of rosin, 4 mg of barium sulfate and 4 mg of bismuth carbonate were mixed to obtain a curing agent (solid agent). Next, the main agent and the curing agent were kneaded (kneaded) for 30 seconds using a metal spatula to obtain a kneaded product (dental composition).
上記のようにして得られた各歯科用組成物（主剤と硬化剤が混練されたもの）について下記評価法に基づいて硬化時間及び硬化度並びに封鎖性を評価した。 Each dental composition obtained as described above (in which the main agent and the curing agent were kneaded) was evaluated for the curing time, the degree of curing, and the sealing property based on the following evaluation methods.
＜硬化時間の測定方法＞
混練（練和）直後の歯科用組成物（ユージノールセメント）を５０ｍｍ×５０ｍｍのガラス板上に置いた内径８ｍｍ、深さ５ｍｍの上端面開放ガラス管に充填（填塞）した。このまま室温（２３℃）に放置し、経時的に、充填物（組成物）の表面に直径１ｍｍ、質量０．２５ポンドのギルモア針を静置させて、（混練開始から）針の侵入が生じなくなるまでの時間を計測し、これを硬化時間とした。
<Measurement method of curing time>
The dental composition (eugenol cement) immediately after kneading (kneading) was filled (filled) into an upper end surface open glass tube having an inner diameter of 8 mm and a depth of 5 mm placed on a 50 mm × 50 mm glass plate. This is allowed to stand at room temperature (23 ° C.), and over time, a Gilmore needle having a diameter of 1 mm and a mass of 0.25 pounds is allowed to stand on the surface of the filling (composition), and the penetration of the needle occurs (from the start of kneading). The time until disappearance was measured, and this was taken as the curing time.
＜硬化物の硬化度評価方法＞
混練（練和）直後の歯科用組成物（ユージノールセメント）を５０ｍｍ×５０ｍｍのガラス板上に置いた内径８ｍｍ、深さ５ｍｍの上端面開放ガラス管に充填（填塞）した。この試料を、３７℃、１００％湿度の恒温恒湿槽に６０分間静置した後、取り出して、先端径１ｍｍ、長さ１００ｍｍの測定針を装着したテクスチャーアナライザ（島津製作所製、品名：ＥＺ Ｔｅｓｔ）の試料台の上に、試料の上面が測定針に接触するように載置して固定し、且つ測定針が試料の中央部に進入するように調整した。試料に測定針が１ｍｍ／秒の速度で進入する際の荷重変化を専用データ処理ソフト（島津製作所製、品名：ＴＲＡＰＥＺＩＵＭ）で記録し、これより硬化度（硬さ）を求めた。なお、測定値は、各実施例及び各比較例毎に試料を３個（ｎ＝３）用意し、３試料の平均値を硬化度（ｋｇｆ）とした。
<Method for evaluating degree of cure of cured product>
The dental composition (eugenol cement) immediately after kneading (kneading) was filled (filled) into an upper end surface open glass tube having an inner diameter of 8 mm and a depth of 5 mm placed on a 50 mm × 50 mm glass plate. The sample was allowed to stand in a constant temperature and humidity chamber at 37 ° C. and 100% humidity for 60 minutes, and then removed, and a texture analyzer (product name: EZ Test, manufactured by Shimadzu Corporation) equipped with a measuring needle having a tip diameter of 1 mm and a length of 100 mm was attached. The sample was placed and fixed on the sample stage so that the upper surface of the sample was in contact with the measurement needle, and the measurement needle was adjusted so as to enter the center of the sample. The load change when the measuring needle entered the sample at a speed of 1 mm / second was recorded with dedicated data processing software (manufactured by Shimadzu Corporation, product name: TRAPEZIUM), and the degree of cure (hardness) was determined from this. In addition, the measured value prepared three samples (n = 3) for each Example and each comparative example, and made the average value of three samples the hardening degree (kgf).
＜封鎖性評価法＞
混練（練和）直後の歯科用組成物（ユージノールセメント）を、内面を粗造にした内径５ｍｍ、長さ３０ｍｍのガラス管（上下両端面が開放）内に深さ２０ｍｍで充填（填塞）した。３７℃、１００％湿度の恒温恒湿槽に２４時間静置した後、取り出して、ガラス管の下半部を３７℃の１％（質量％）メチレンブルー水溶液中に９６時間浸漬した。しかる後、前記充填ガラス管を取り出し、電子ノギスでガラス管下端からの色素の（上方への）侵入距離を測定した。なお、比較のために、市販の歯牙根管充填材であるキャナルス（商品名）（昭和薬品化工製、主成分はユージノール）及び同じく市販の歯牙根管充填材であるキャナルスＮ（商品名）（昭和薬品化工製、主成分はリノール酸）についても同様にして封鎖性を評価した。これらの結果を表２に示す。
<Evaluation method for blockage>
The dental composition (eugenol cement) immediately after kneading (kneading) was filled (filled) at a depth of 20 mm in a glass tube having a rough inner surface and an inner diameter of 5 mm and a length of 30 mm (both upper and lower end surfaces were open). . After leaving still in a constant temperature and humidity chamber of 37 ° C. and 100% humidity for 24 hours, it was taken out and the lower half of the glass tube was immersed in a 1% (mass%) methylene blue aqueous solution at 37 ° C. for 96 hours. Thereafter, the filled glass tube was taken out, and the penetration distance (upward) of the dye from the lower end of the glass tube was measured with an electronic caliper. In addition, for comparison, Canals (trade name) (manufactured by Showa Yakuhin Kako, the main component is Eugenol), which is a commercially available tooth root canal filler, and Canals N (trade name), which is also a commercially available tooth root canal filler ( The blocking property was also evaluated in the same manner for Showa Yakuhin Kako, whose main component is linoleic acid. These results are shown in Table 2.
表１から明らかなように、この発明の実施例１〜３の歯科用組成物は、高い硬化度が得られており十分に硬化させることができると共に、硬化時間は３０分〜１２０分の範囲内であり適度な硬化時間であった。即ち、例えば歯科治療等において十分な操作時間を確保できる。 As is apparent from Table 1, the dental compositions of Examples 1 to 3 of the present invention have a high degree of curing and can be sufficiently cured, and the curing time ranges from 30 minutes to 120 minutes. The curing time was moderate. That is, for example, sufficient operation time can be secured in dental treatment.
これに対し、イソステアリン酸を全く含有しない比較例１では、硬化時間が５分と短いために実用に適さない。即ち、例えば歯科治療等において十分な操作時間を確保できない。また、イソステアリン酸の含有割合がこの発明の規定範囲より多い比較例２では、硬化時間が遅くなり過ぎていて実用に適さない。 On the other hand, Comparative Example 1 containing no isostearic acid is not suitable for practical use because the curing time is as short as 5 minutes. That is, for example, sufficient operation time cannot be secured in dental treatment. Further, in Comparative Example 2 in which the content ratio of isostearic acid is larger than the specified range of the present invention, the curing time is too slow and is not suitable for practical use.
また、表２から明らかなように、この発明の実施例１〜３の歯科用組成物の硬化物は、色素が全く侵入しておらず、封鎖性に非常に優れていることがわかる。 Further, as is apparent from Table 2, it can be seen that the cured products of the dental compositions of Examples 1 to 3 of the present invention have very good sealing properties because no pigment has penetrated.
これに対し、参照例１のキャナルスでは、色素の侵入距離が２０ｍｍであり（即ち色素が上下に浸透貫通している）、封鎖性が悪かった。また、参照例２のキャナルスＮでは、色素の侵入距離が１．８ｍｍであり、封鎖性は良くなかった。 On the other hand, in the canals of Reference Example 1, the penetration distance of the dye was 20 mm (that is, the dye penetrated and penetrated up and down), and the blocking property was poor. Further, in Canals N of Reference Example 2, the penetration distance of the dye was 1.8 mm, and the sealing property was not good.
この発明に係る歯科用組成物は、例えば、歯牙根管充填材、仮封材、歯髄鎮痛消炎剤、覆髄剤等として好適に用いられる。 The dental composition according to the present invention is suitably used as, for example, a tooth root canal filling material, a temporary sealing material, a dental pulp analgesic / antiinflammatory agent, a pulp capping agent, and the like.
Claims (3)
前記主剤は、ユージノール、オレイン酸及びイソステアリン酸を含有してなり、
前記硬化剤は、酸化亜鉛を含有してなり、
これらの配合割合が、ユージノール３μＬ当たりに対し、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇの配合割合であることを特徴とする歯科用組成物。 A dental composition comprising a main agent and a hardener, which is cured by mixing the main agent and the hardener,
The main agent comprises eugenol, oleic acid and isostearic acid,
The curing agent contains zinc oxide,
A dental composition characterized in that these blending ratios are blending ratios of oleic acid 10 to 16.5 μL, isostearic acid 0.5 to 7 μL, and zinc oxide 10 to 25 mg per 3 μL of Eugenol.
前記主剤は、ユージノールを含有してなり、
前記硬化剤は、酸化亜鉛を含有してなり、
オレイン酸が、前記主剤及び前記硬化剤のうちの少なくともいずれか一方に含有せしめられ、
イソステアリン酸が、前記主剤及び前記硬化剤のうちの少なくともいずれか一方に含有せしめられ、
これらの配合割合が、ユージノール３μＬ当たりに対し、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇの配合割合であることを特徴とする歯科用組成物。 A dental composition comprising a main agent and a hardener, which is cured by mixing the main agent and the hardener,
The main agent contains eugenol,
The curing agent contains zinc oxide,
Oleic acid is contained in at least one of the main agent and the curing agent,
Isostearic acid is contained in at least one of the main agent and the curing agent,
A dental composition characterized in that these blending ratios are blending ratios of oleic acid 10 to 16.5 μL, isostearic acid 0.5 to 7 μL, and zinc oxide 10 to 25 mg per 3 μL of Eugenol.
これらの配合割合が、ユージノール３μＬ当たりに対し、オレイン酸１０〜１６．５μＬ、イソステアリン酸０．５〜７μＬ、酸化亜鉛１０〜２５ｍｇの配合割合であることを特徴とする歯科用組成物。 Containing eugenol, oleic acid, isostearic acid and zinc oxide;
A dental composition characterized in that these blending ratios are blending ratios of oleic acid 10 to 16.5 μL, isostearic acid 0.5 to 7 μL, and zinc oxide 10 to 25 mg per 3 μL of Eugenol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008279157A JP5280801B2 (en) | 2008-10-30 | 2008-10-30 | Dental composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2008279157A JP5280801B2 (en) | 2008-10-30 | 2008-10-30 | Dental composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010105953A JP2010105953A (en) | 2010-05-13 |
| JP5280801B2 true JP5280801B2 (en) | 2013-09-04 |
Family
ID=42295766
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008279157A Expired - Fee Related JP5280801B2 (en) | 2008-10-30 | 2008-10-30 | Dental composition |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5280801B2 (en) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2108132B (en) * | 1981-08-21 | 1985-05-30 | Double H International Marketi | Improvements in dental cements based on metal oxides or hydroxides and eugenol |
| JPS6291447A (en) * | 1985-10-17 | 1987-04-25 | 昭和薬品化工株式会社 | Cement composition |
-
2008
- 2008-10-30 JP JP2008279157A patent/JP5280801B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010105953A (en) | 2010-05-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| McMichen et al. | A comparative study of selected physical properties of five root‐canal sealers | |
| El Hachem et al. | Dentinal tubule penetration of AH Plus, BC Sealer and a novel tricalcium silicate sealer: a confocal laser scanning microscopy study | |
| Bresciani et al. | Compressive and diametral tensile strength of glass ionomer cements | |
| Butt et al. | Comparison of physical and mechanical properties of mineral trioxide aggregate and Biodentine | |
| DE2932823A1 (en) | MIXING COMPONENT FOR GLASIONOMER CEMENTS | |
| EP3111913B1 (en) | Single paste type dental hydraulic-setting filler composition | |
| Bernardi et al. | Effects of the addition of nanoparticulate calcium carbonate on setting time, dimensional change, compressive strength, solubility and pH of MTA | |
| JP2013053075A (en) | Dental cement composition | |
| JP2014529339A (en) | New hemostatic composition | |
| JP6744399B2 (en) | Dental cement | |
| JP2011213608A (en) | Dental hydraulic temporary sealing material composition | |
| Marquezan et al. | Effect of blood contamination on the push-out bond strength of calcium silicate cements | |
| JP2002087922A (en) | Alginate impression material composition for dental use | |
| JP5280801B2 (en) | Dental composition | |
| JP6152412B2 (en) | Dental filling composition containing zirconia powder | |
| El Briak et al. | Study of a hydraulic dicalcium phosphate dihydrate/calcium oxide‐based cement for dental applications | |
| Raggio et al. | Effect of insertion method on knoop hardness of high viscous glass ionomer cements | |
| JP5785956B2 (en) | Insert material for gingival crevice expansion | |
| Shashank et al. | Comparative pH and calcium ion release in newer calcium silicate-based root canal sealers | |
| JP5225566B2 (en) | Powdered dental alginate impression material | |
| Anderson Jr et al. | Physical properties of some zinc oxide-eugenol cements | |
| JPWO2014017360A1 (en) | Hardener paste and alginate curable composition preparation kit | |
| JP6099425B2 (en) | Dental alginate impression material | |
| JP6893148B2 (en) | Dental cement | |
| Kaul et al. | Evaluation of biological, physical and chemical properties of mineral trioxide aggregate mixed with 4-META/MMA-TBB |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20110809 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130514 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130523 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 5280801 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D02 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |