JP5275570B2 - Hair swell improver - Google Patents
Hair swell improver Download PDFInfo
- Publication number
- JP5275570B2 JP5275570B2 JP2007019044A JP2007019044A JP5275570B2 JP 5275570 B2 JP5275570 B2 JP 5275570B2 JP 2007019044 A JP2007019044 A JP 2007019044A JP 2007019044 A JP2007019044 A JP 2007019044A JP 5275570 B2 JP5275570 B2 JP 5275570B2
- Authority
- JP
- Japan
- Prior art keywords
- hair
- scalp
- extract
- external preparation
- swell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Landscapes
- Cosmetics (AREA)
Description
本発明は、加齢の進行に伴い増加する毛髪のうねりを改善できる毛髪うねり改善剤に関する。 The present invention relates to a hair waviness improving agent that can improve hair waviness that increases with the progress of aging.
加齢に伴う毛髪の老化現象として、毛髪径の低下や生毛密度の低下によって薄毛が進行したり、白髪が増加したりすることが広く知られている。しかし本発明者らは、加齢に伴う毛髪の老化現象を詳しく調べた結果、加齢に伴って、上記の薄毛の進行、白髪の増加以外に、うねった形状の毛髪(うねり毛)の割合が増加することを見出した。更に、このようなうねり毛においては、直毛と比較して、毛髪内部の細胞構造に差異が生じていることを見出した。このようなうねり毛が増加すると、髪のまとまりが悪化すると同時に、髪の艶が低下し、加齢者の髪悩みにつながっていると考えられる。 As aging phenomenon of hair with aging, it is widely known that thin hair progresses or white hair increases due to a decrease in hair diameter or a reduction in raw hair density. However, as a result of examining the aging phenomenon of hair with aging in detail, the present inventors have found that the proportion of undulating hair (undulation hair) in addition to the above-mentioned progress of thinning hair and increase in gray hair with aging Found to increase. Furthermore, it has been found that in such wavy hair, there is a difference in the cell structure inside the hair compared to straight hair. If such waviness increases, it is considered that the hair mass deteriorates and at the same time the gloss of the hair decreases, leading to the hair problems of the aged.
従来、加齢者が訴える、毛髪径の低下や生毛密度の低下といった髪悩みの対策として、毛髪のハリ・コシを補強する処理(例えば特許文献1)やボリューム感を与える処理(例えば特許文献2)等が提案されているが、これらはいずれも一時的な対処法にすぎなかった。また、うねり毛にストレートパーマ処理することにより直毛化することも、従来広く行われているが、毛髪そのものに対するダメージが避けがたく、十分満足できるものではなかった。 Conventionally, as a countermeasure against hair problems such as a decrease in hair diameter and a decrease in raw hair density, which is appealed by aging people, a process for reinforcing the firmness and stiffness of hair (for example, Patent Document 1) and a process for giving a sense of volume (for example, Patent Document) 2) etc. have been proposed, but these were only temporary countermeasures. In addition, straight hair treatment by treating the wavy hair with a straight perm has also been widely performed, but damage to the hair itself is unavoidable and not fully satisfactory.
従って、本発明の目的は、加齢に伴う毛髪のうねりを、一時的でなく、永続的に改善することができる毛髪うねり改善剤を提供することにある。 Accordingly, an object of the present invention is to provide a hair undulation improving agent capable of improving hair undulation accompanying aging not permanently but permanently.
本発明者らは、ユーカリ属植物の抽出物(以下ユーカリエキスという)を頭皮に連用することにより、加齢に伴う毛髪のうねりを改善できることを見出した。 The present inventors have found that undulation of hair accompanying aging can be improved by continuously using an extract of Eucalyptus plant (hereinafter referred to as Eucalyptus extract) on the scalp.
本発明は、ユーカリエキスを有効成分とする毛髪うねり改善剤、及びユーカリエキスの毛髪うねり改善剤としての使用を提供するものである。 The present invention provides a hair swell improver comprising eucalyptus extract as an active ingredient, and the use of eucalyptus extract as a hair swell improver.
本発明の毛髪うねり改善剤は、頭皮に連用することにより、何らの副作用を伴うことなく、毛髪のうねりを改善し、加齢に伴う髪悩みを軽減できる。 The hair swell improving agent of the present invention can improve hair swell and reduce the worries associated with aging without any side effects by being used on the scalp.
以下、本明細書において、単に毛髪うねりという場合は、加齢の進行に伴い増加するうねりを意味する。 Hereinafter, in this specification, the term “hair swell” simply means swell that increases with the progress of aging.
<ユーカリエキス>
本発明の毛髪うねり改善剤の有効成分であるユーカリエキスの原料としては、例えばフトモモ科ユーカリ属植物であるユーカリプタス・グロブラス(Eucalyptus globulus)が挙げられる。ユーカリ属植物は,世界各地の温暖な地域に分布する常緑高木の広葉樹であり、近年は、パルプ用材とすることを目的としてオーストラリア、ニュージーランド等で積極的に植林されている樹種である。パルプ用材や薬用として用いられる以外に、公園樹、庭園樹、建築材、器具材等の広い用途をもつ。
<Eucalyptus extract>
Examples of the raw material of the eucalyptus extract that is an active ingredient of the hair swell improving agent of the present invention include Eucalyptus globulus, which is a plant belonging to the genus Eucalyptus. Eucalyptus plants are hardwood evergreen trees distributed in temperate regions around the world, and in recent years have been actively planted in Australia, New Zealand, etc. for the purpose of making pulp. Besides being used for pulp and medicinal purposes, it has a wide range of uses such as park trees, garden trees, building materials, and instrument materials.
本発明の毛髪うねり改善剤の有効成分であるユーカリエキスは、例えば、ユーカリ属植物の葉や枝などから、溶剤抽出によって得ることができる。このユーカリ属植物の枝や葉等は、そのままあるいは乾燥粉砕して溶剤による抽出に用いることができる。 The eucalyptus extract which is an active ingredient of the hair swell improving agent of the present invention can be obtained, for example, from the leaves or branches of Eucalyptus plants by solvent extraction. The branches, leaves, etc. of the Eucalyptus plant can be used as they are or after dry pulverization for extraction with a solvent.
抽出用の溶剤としては、極性溶剤が好ましく、水、低級アルコール類、グリコール類、ケトン類、エステル類等が挙げられる。低級アルコール類としては、炭素数1〜6の炭化水素基を有するアルコール類、具体的にはメタノール、エタノール、プロパノール等が挙げられ;グリコール類としては、エチレングリコール、ジエチレングリコール、ブチレングリコール、プロピレングリコール等が挙げられ;ケトン類としては、アセトン、メチルエチルケトン等が挙げられ;エステル類としては、酢酸エチル、酢酸プロピル、ギ酸エチル等が挙げられる。これらの溶剤は単独で、若しくは水溶液として用いてもよく、又は任意の2種若しくは3種以上の混合溶剤として用いてもよい。 The solvent for extraction is preferably a polar solvent, and examples thereof include water, lower alcohols, glycols, ketones, and esters. Examples of lower alcohols include alcohols having a hydrocarbon group having 1 to 6 carbon atoms, specifically methanol, ethanol, propanol, etc .; examples of glycols include ethylene glycol, diethylene glycol, butylene glycol, propylene glycol, etc. Examples of the ketones include acetone and methyl ethyl ketone; Examples of the esters include ethyl acetate, propyl acetate, and ethyl formate. These solvents may be used alone or as an aqueous solution, or may be used as any two or three or more mixed solvents.
好ましいユーカリエキスは、ユーカリプタス・グロブラス(Eucalyptus globulus)の葉の極性溶剤抽出物であり、市販品をそのまま用いることもできる。市販品としては、ファルコレックス ユーカリB(一丸ファルコス社)、ユーカリエキスTH(長谷川香料社)、ユーカリ抽出液BGF(丸善製薬社)等がある。これらはいずれも、固形分を0.1〜2重量%程度、ブチレングリコール(1,3-ブタンジオール)及び/又はエタノールを40〜90重量%程度含み、残余水のものである。 A preferred eucalyptus extract is a polar solvent extract of Eucalyptus globulus leaves, and commercially available products can also be used as they are. Commercially available products include Falco Rex Eucalyptus B (Ichimaru Falcos), Eucalyptus Extract TH (Hasegawa Fragrance), Eucalyptus Extract BGF (Maruzen Pharmaceutical). All of them contain about 0.1 to 2% by weight of the solid content, about 40 to 90% by weight of butylene glycol (1,3-butanediol) and / or ethanol, and the residual water.
本発明の毛髪うねり改善剤は、水、水/エタノール混合溶剤等を媒体とし、頭皮化粧料や外用医薬品(以下、両者をあわせて単に頭皮外用剤という)に含有させることができる。頭皮外用剤中のユーカリエキスの含有量は、固形分換算で好ましくは0.0001〜0.5重量%、より好ましくは0.0005〜0.1重量%、更に好ましくは0.001〜0.05重量%である。 The hair swell improving agent of the present invention can be contained in scalp cosmetics or external medicines (hereinafter, both are simply referred to as scalp external preparations) using water, water / ethanol mixed solvent or the like as a medium. The content of the eucalyptus extract in the scalp external preparation is preferably 0.0001 to 0.5% by weight, more preferably 0.0005 to 0.1% by weight, and still more preferably 0.001 to 0.05% by weight in terms of solid content.
<溶剤>
また、かかる頭皮外用剤には、水のほか、溶剤、あるいは浸透促進剤として、エタノール、1-プロパノール、2-プロパノール、n-ブタノール等の脂肪族アルコール;2-フェノキシエタノール、ベンジルアルコール、2-フェニルエタノール、2-ベンジルオキシエタノール等の芳香族アルコール;トリエチレングリコール、1,3-ブチレングリコール、プロピレングリコール、ヘキシレングリコール、ジエチレングリコール等のグリコール類等のアルコール類を用いることができる。
<Solvent>
In addition to water, such a scalp external preparation includes, as a solvent or a penetration enhancer, an aliphatic alcohol such as ethanol, 1-propanol, 2-propanol, n-butanol; 2-phenoxyethanol, benzyl alcohol, 2-phenyl Aromatic alcohols such as ethanol and 2-benzyloxyethanol; alcohols such as glycols such as triethylene glycol, 1,3-butylene glycol, propylene glycol, hexylene glycol and diethylene glycol can be used.
これらアルコール類は、単独で又は2種類以上を組み合わせて使用することができ、またその含有量は、頭皮外用剤中、0.05〜60質量%、更には1〜50質量%、特に5〜40質量%が好ましい。 These alcohols can be used alone or in combination of two or more, and the content thereof is 0.05 to 60% by mass, further 1 to 50% by mass, particularly 5 to 40% by mass in the scalp external preparation. % Is preferred.
<粘度>
更に、頭皮外用剤の粘度は、適切な量の毛髪うねり改善剤が頭皮上に留まることで十分な効果を期待でき、かつ頭髪上に均一に塗布しやすくする観点から、ブルックフィールド型粘度計による測定値で、1〜90,000mPa・s、更には2〜50,000mPa・s、特に3〜10,000mPa・sの範囲内であることが望ましい。
<Viscosity>
Furthermore, the viscosity of the external preparation for scalp is determined by the Brookfield viscometer from the viewpoint that a sufficient amount of hair swell improver can remain on the scalp, and that it can be applied uniformly on the scalp. The measured value is preferably in the range of 1 to 90,000 mPa · s, more preferably 2 to 50,000 mPa · s, particularly 3 to 10,000 mPa · s.
<水溶性高分子>
頭皮外用剤の粘度を所望の範囲にするためには、合成又は天然の水溶性高分子を用いることができる。
<Water-soluble polymer>
In order to bring the viscosity of the scalp external preparation into a desired range, a synthetic or natural water-soluble polymer can be used.
合成又は天然の水溶性高分子としては、塩化ジメチルジアリルアンモニウム・アクリルアミド共重合体(例えば、Nalco社;マーコート100、マーコート550)、ビニルピロリドン・ジメチルアミノエチルメタクリレート共重合体(例えば、ISP社;コポリマー845、コポリマー937、コポリマー958)、アクリル酸・メタクリル酸アルキル共重合体(例えば、Noveon社;ペムレンTR-1、TR-2)、塩化o-[2-ヒドロキシ-3-(ラウリルジメチルアンモニオ)プロピル]ヒドロキシエチルセルロース(例えば、ザ・ダウ・ケミカル・カンパニー社;ポリマーJR-125、JR-30M、JR-400、ライオン社;レオガードG)、塩化o-[2-ヒドロキシ-3-(トリメチルアンモニオ)プロピル]グアーガム(例えば、大日本住友製薬社;ラボールガムCG-M、ラボールガムCG-6L、ラボールガムCG-M7、ラボールガムCG-M8M、ローディア社;ジャガーC-13S、ジャガーC-14S、ジャガーC-17、ジャガーC-210、ジャガーC-162、HI-CARE1000)、カチオン化デキストラン、メチルセルロース(例えば、信越化学社;メトローズSM)、エチルセルロース(例えば、Gattefosse社;ブリリアンス515)、ヒドロキシエチルセルロース(例えば、ザ・ダウ・ケミカル・カンパニー社;セロサイズQP4400H、QP52000H、ダイセル化学工業社;SE-600、SE-850)、ヒドロキシプロピルセルロース(例えば、日本曹達社;日曹HPC-H、HPC-M)、ヒドロキシプロピルメチルセルロース(例えば、信越化学社;メトローズ60SHシリーズ、メトローズ65SHシリーズ、メトローズ90SHシリーズ)、プルラン(例えば、林原社;プルランPF-20、プルランPI-20)、プルラン脂肪酸エステル、キサンタンガム(例えば、大日本住友製薬社;エコーガム)、ヒドロキシプロピルキサンタンガム(例えば、大日本住友製薬社;ラボールガムEX)等が挙げられる。 Synthetic or natural water-soluble polymers include dimethyldiallylammonium chloride / acrylamide copolymer (for example, Nalco; Marcote 100, Marcote 550), vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (for example, ISP; copolymer) 845, copolymer 937, copolymer 958), acrylic acid / alkyl methacrylate copolymer (for example, Noveon; Pemlene TR-1, TR-2), o- [2-hydroxy-3- (lauryldimethylammonio) chloride Propyl] hydroxyethylcellulose (for example, The Dow Chemical Company; Polymer JR-125, JR-30M, JR-400, Lion; Leogard G), o- [2-hydroxy-3- (trimethylammonio) chloride ) Propyl] guar gum (eg, Dainippon Sumitomo Pharma; Labor gum CG-M, Labor gum CG-6L, Labor gum CG-M7, Labor gum) CG-M8M, Rhodia; Jaguar C-13S, Jaguar C-14S, Jaguar C-17, Jaguar C-210, Jaguar C-162, HI-CARE1000), cationized dextran, methylcellulose (for example, Shin-Etsu Chemical Co., Ltd .; Metroles) SM), ethyl cellulose (for example, Gattefosse; Brilliance 515), hydroxyethyl cellulose (for example, The Dow Chemical Company; cellosize QP4400H, QP52000H, Daicel Chemical Industries; SE-600, SE-850), hydroxypropylcellulose (For example, Nippon Soda Co., Ltd .; Nisso HPC-H, HPC-M), hydroxypropyl methylcellulose (for example, Shin-Etsu Chemical Co., Ltd .; Metroles 60SH series, Metroles 65SH series, Metroles 90SH series), pullulan (for example, Hayashibara Corporation; -20, pullulan PI-20), pullulan fatty acid ester, xanthan gum (eg, Sumitomo Dainippon Pharma) Echo Gum), hydroxypropyl xanthan gum (for example, Dainippon Sumitomo Pharma; Labor Gum EX) and the like.
これら天然高分子及び合成高分子は、単独で又は2種類以上を組み合わせて使用することができ、またその含有量は、頭皮外用剤中の0.01〜20質量%、更には0.02〜10質量%、特に0.05〜5質量%が好ましい。 These natural polymers and synthetic polymers can be used alone or in combination of two or more thereof, and the content thereof is 0.01 to 20% by mass, further 0.02 to 10% by mass in the scalp external preparation, Especially 0.05-5 mass% is preferable.
<界面活性剤>
頭皮外用剤には、油性成分や香料の乳化、分散、可溶化等の目的で、非イオン界面活性剤、両性界面活性剤、カチオン界面活性剤、アニオン界面活性剤等の界面活性剤を含有させることができる。
<Surfactant>
The scalp external preparation contains surfactants such as nonionic surfactants, amphoteric surfactants, cationic surfactants and anionic surfactants for the purpose of emulsifying, dispersing and solubilizing oily components and fragrances. be able to.
非イオン界面活性剤としては、ポリオキシアルキレンアルキルエーテル、ポリオキシアルキレンアルケニルエーテル、高級脂肪酸ショ糖エステル、ポリグリセリン脂肪酸エステル、高級脂肪酸モノ又はジエタノールアミド、ポリオキシエチレン硬化ヒマシ油、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレンソルビット脂肪酸エステル、アルキルサッカライド系界面活性剤、アルキルアミンオキサイド、アルキルアミドアミンオキサイド等が挙げられる。これらのうち、ポリオキシアルキレンアルキルエーテル、ポリオキシエチレン硬化ヒマシ油が好ましく、ポリオキシエチレンアルキルエーテルが特に好ましい。ポリオキシエチレンアルキルエーテルとしては、下記一般式で表されるものが好ましい。 Nonionic surfactants include polyoxyalkylene alkyl ether, polyoxyalkylene alkenyl ether, higher fatty acid sucrose ester, polyglycerin fatty acid ester, higher fatty acid mono- or diethanolamide, polyoxyethylene hydrogenated castor oil, polyoxyethylene sorbitan fatty acid Examples thereof include esters, polyoxyethylene sorbite fatty acid esters, alkyl saccharide surfactants, alkyl amine oxides, and alkyl amido amine oxides. Of these, polyoxyalkylene alkyl ether and polyoxyethylene hydrogenated castor oil are preferable, and polyoxyethylene alkyl ether is particularly preferable. As polyoxyethylene alkyl ether, what is represented by the following general formula is preferable.
〔式中、R1は炭素数8〜18の直鎖又は分岐鎖のアルキル基を示し、nは1〜25の数を示す。〕 [Wherein, R 1 represents a linear or branched alkyl group having 8 to 18 carbon atoms, and n represents a number of 1 to 25. ]
両性界面活性剤としては、イミダゾリン系、カルボベタイン系、アミドベタイン系、スルホベタイン系、ヒドロキシスルホベタイン系、アミドスルホベタイン系等が挙げられる。特に、アルキルジメチルアミノ酢酸ベタイン、脂肪酸アミドプロピルベタイン等のベタイン系界面活性剤がより好ましく、脂肪酸アミドプロピルベタインが特に好ましい。脂肪酸アミドプロピルベタインは、炭素数8〜18、特に炭素数10〜16のアシル基を有するものが好ましく、特にラウリン酸アミドプロピルベタイン、パーム核油脂肪酸アミドプロピルベタイン、ヤシ油脂肪酸アミドプロピルベタイン等が好ましい。 Examples of amphoteric surfactants include imidazoline series, carbobetaine series, amide betaine series, sulfobetaine series, hydroxysulfobetaine series, and amide sulfobetaine series. In particular, betaine surfactants such as alkyldimethylaminoacetic acid betaine and fatty acid amidopropyl betaine are more preferred, and fatty acid amidopropyl betaine is particularly preferred. The fatty acid amidopropyl betaine is preferably one having an acyl group having 8 to 18 carbon atoms, particularly 10 to 16 carbon atoms, and in particular, lauric acid amidopropyl betaine, palm kernel oil fatty acid amidopropyl betaine, coconut oil fatty acid amidopropyl betaine and the like. preferable.
カチオン界面活性剤としては、炭素数16以上のモノ又はジ長鎖アルキル四級アンモニウム塩が好ましく、具体的には、塩化ステアリルトリメチルアンモニウム、塩化アラキルトリメチルアンモニウム、塩化ベヘニルトリメチルアンモニウム、塩化アルキルベンザルコニウム等が挙げられ、特に塩化ステアリルトリメチルアンモニウム、塩化ベヘニルトリメチルアンモニウムが好ましい。 The cationic surfactant is preferably a mono- or di-long alkyl quaternary ammonium salt having 16 or more carbon atoms, and specifically, stearyltrimethylammonium chloride, aralkyltrimethylammonium chloride, behenyltrimethylammonium chloride, alkylbenzalkolo chloride. In particular, stearyltrimethylammonium chloride and behenyltrimethylammonium chloride are preferable.
アニオン界面活性剤としては、アルキルベンゼンスルホン酸塩、アルキル又はアルケニルエーテル硫酸塩、アルキル又はアルケニル硫酸塩、オレフィンスルホン酸塩、アルカンスルホン酸塩、飽和又は不飽和脂肪酸塩、アルキル又はアルケニルエーテルカルボン酸塩、α-スルホン脂肪酸塩、N-アシルアミノ酸型界面活性剤、リン酸モノ又はジエステル型界面活性剤、スルホコハク酸エステル等が挙げられる。これらのアニオン界面活性剤のアニオン性残基の対イオンとしては、ナトリウムイオン、カリウムイオン等のアルカリ金属イオン;カルシウムイオン、マグネシウムイオン等のアルカリ土類金属イオン;アンモニウムイオン;炭素数2又は3のアルカノール基を1〜3個有するアルカノールアミン(例えばモノエタノールアミン、ジエタノールアミン、トリエタノールアミン、トリイソプロパノールアミン等)を挙げることができる。 Anionic surfactants include alkyl benzene sulfonates, alkyl or alkenyl ether sulfates, alkyl or alkenyl sulfates, olefin sulfonates, alkane sulfonates, saturated or unsaturated fatty acid salts, alkyl or alkenyl ether carboxylates, Examples include α-sulfone fatty acid salts, N-acylamino acid type surfactants, phosphate mono- or diester type surfactants, and sulfosuccinate esters. Counter ions of anionic residues of these anionic surfactants include alkali metal ions such as sodium ions and potassium ions; alkaline earth metal ions such as calcium ions and magnesium ions; ammonium ions; Examples thereof include alkanolamines having 1 to 3 alkanol groups (for example, monoethanolamine, diethanolamine, triethanolamine, triisopropanolamine).
これらの界面活性剤は、単独で又は2種類以上を組み合わせて使用することができ、全含有量は、良好な感触の観点から、頭皮外用剤中の0.01〜20質量%が好ましく、更には0.05〜15質量%、特に0.1〜10質量%が好ましい。 These surfactants can be used alone or in combination of two or more, and the total content is preferably 0.01 to 20% by mass in the scalp external preparation from the viewpoint of good feel, and more preferably 0.05. -15% by mass, particularly 0.1-10% by mass is preferred.
<育毛・養毛成分>
頭皮外用剤は、更に育毛・養毛成分を含有することが好ましい。育毛・養毛成分を加えることにより、毛髪うねり改善効果を向上することができる。このような育毛・養毛成分としては、頭皮の血行を促進して毛髪の成長を促す血行促進剤や、毛包を活性化して毛髪の成長を促す毛包賦活剤に加え、抗男性ホルモン剤、カリウムイオンチャンネルオープナー等が挙げられる。
<Hair-growth / hair-restoring ingredients>
It is preferable that the scalp external preparation further contains a hair growth / hair growth component. The effect of improving hair swell can be improved by adding a hair growth / hair nourishing ingredient. As such hair growth and hair restoration ingredients, in addition to a blood circulation promoter that promotes blood circulation of the scalp and promotes hair growth, and a hair follicle activator that activates hair follicles and promotes hair growth, an anti-androgen agent And potassium ion channel opener.
血行促進剤としては、二酸化炭素、アセチルコリン、塩化カルプロニウム、スピロノラクトン、ビタミンB6塩酸塩、γ-オリザノール、サークレチン、クロマカリム、セファランチン、ニコランジル、ビタミンE類(DL-α-トコフェロール、D-α-トコフェロール、酢酸DL-α-トコフェロール、酢酸D-α-トコフェロール等)、ニコチン酸類(ニコチン酸、DL-α-トコフェロールニコチン酸エステル、ニコチン酸アミド、ニコチン酸ベンジル等)、ピナシジル、ミノキシジル、フタリド類、ジイソプロピルアミンジクロロアセテート、ニンジンエキス、センブリエキス、ヨウ化ニンニクエキス、イチョウエキス、キナエキス、ショウブ根エキス、ソフォラ抽出液、トウヒエキス、当薬エキス、トウガラシチンキ、ユズ抽出液、カンタリスチンキ、ショウキョウチンキ等が挙げられる。これらのうち、ビタミンE類、ニコチン酸類、ジイソプロピルアミンジクロロアセテート、センブリエキス、トウガラシチンキが好ましい。 Examples of the blood circulation promoter include carbon dioxide, acetylcholine, carpronium chloride, spironolactone, vitamin B 6 hydrochloride, γ-oryzanol, cerretin, cromakalim, cephalanthin, nicorandil, vitamin E (DL-α-tocopherol, D-α-tocopherol, DL-α-tocopherol acetate, D-α-tocopherol acetate, etc.), nicotinic acids (nicotinic acid, DL-α-tocopherol nicotinate, nicotinamide, benzyl nicotinate, etc.), pinacidil, minoxidil, phthalides, diisopropylamine Dichloroacetate, carrot extract, assembly extract, iodized garlic extract, ginkgo biloba extract, kina extract, ginger root extract, sophora extract, spruce extract, medicinal extract, capsicum tincture, yuzu extract, cantalis tincture, ginger Uchinki, and the like. Of these, vitamin Es, nicotinic acids, diisopropylamine dichloroacetate, assembly extract, and chili tincture are preferable.
毛包賦活剤としては、フラバノノール類(トランス-3,4'-ジメチルフラバノノール等)、パントテン酸類(パントテン酸、パントテン酸エステル、パンテノール、パントテニルエチルエーテル等)、N-アシルアミノ酸、ペンタデカン酸グリセリド、6-ベンジルアミノプリン、プロシアニジン、アデノシン類(アデノシン、アデノシン5'-リン酸、アデノシン5'-リン酸の塩等)、アスパラギン酸カリウム、感光素301、ビオチン、モノニトログアヤコールナトリウム、N-アセチル-L-メチオニン、タマサキツヅラフジエキス、ニンジンエキス(チクセツニンジンエキス、オタネニンジンエキス等)、ブドウエキス、リンゴエキス、酵母エキス、ニンニク成分、真珠蛋白抽出液、プラセンタエキス、タイソウエキス、ローヤルゼリー等が挙げられる。これらのうち、フラバノノール類、パントテン酸類、N-アシルアミノ酸、ペンタデカン酸グリセリド、6-ベンジルアミノプリン、プロシアニジン、ビオチン、モノニトログアヤコールナトリウム、タマサキツヅラフジエキス、プラセンタエキス、ローヤルゼリーが好ましく、更にはフラバノノール類、パントテン酸類、N-アシルアミノ酸、ペンタデカン酸グリセリド、6-ベンジルアミノプリン、プロシアニジンが好ましく、特にフラバノノール類が好ましい。 Examples of hair follicle activators include flavonols (such as trans-3,4'-dimethylflavanol), pantothenic acids (such as pantothenic acid, pantothenic acid ester, panthenol, pantothenyl ethyl ether), N-acylamino acids, pentadecane Acid glycerides, 6-benzylaminopurine, procyanidins, adenosines (adenosine, adenosine 5'-phosphate, adenosine 5'-phosphate salts, etc.), potassium aspartate, photosensitizer 301, biotin, mononitroguaiacol sodium, N -Acetyl-L-methionine, Japanese cypress rafji extract, carrot extract (Chixet carrot extract, Panax ginseng extract, etc.), grape extract, apple extract, yeast extract, garlic component, pearl protein extract, placenta extract, peanut extract, royal jelly, etc. Is mentioned. Of these, flavonols, pantothenic acids, N-acylamino acids, pentadecanoic acid glycerides, 6-benzylaminopurine, procyanidins, biotin, mononitroguaiacol sodium, Japanese cypress raft extract, placenta extract, and royal jelly are preferred, and flavonanols , Pantothenic acids, N-acylamino acids, pentadecanoic acid glycerides, 6-benzylaminopurine and procyanidins are preferred, and flavonanols are particularly preferred.
抗男性ホルモン剤としては、サイプロテロンアセテート、11α-ハイドロキシプロゲステロン、フルタマイド、3-デオキシアデノシン、酢酸クロルマジノン、エチニルエストラジオール、スピロノラクトン、エピテステロン、フィナステライド、アロエ、サンショウ、チョウジエキス、クアチャララーテエキス、オタネニンジン等が挙げられる。 Anti-androgenic agents include cyproterone acetate, 11α-hydroxyprogesterone, flutamide, 3-deoxyadenosine, chlormadinone acetate, ethinyl estradiol, spironolactone, epitesterone, finasteride, aloe, salamander, clove extract, quacharate extract, ginseng Etc.
カリウムイオンチャンネルオープナーとしては、ミノキシジル、クロマカリム、ジアゾキシド及びその誘導体、ピナシジル等が挙げられる。 Examples of the potassium ion channel opener include minoxidil, cromakalim, diazoxide and derivatives thereof, and pinacidil.
頭皮外用剤に配合される育毛・養毛成分の含有量は、十分な育毛効果と刺激抑制の観点から、頭皮外用剤中の0.001〜10質量% 、特に0.01〜5質量%が好ましい。 The content of the hair-growth / hair-growth component blended in the scalp external preparation is preferably 0.001 to 10% by mass, particularly 0.01 to 5% by mass in the scalp external preparation from the viewpoint of sufficient hair-growth effect and suppression of irritation.
<薬効成分>
頭皮外用剤は、上記の育毛・養毛成分以外にも、種々の薬効成分を含むことができる。薬効成分としては、抗菌剤、抗炎症剤、保湿剤、角質溶解剤、抗脂漏剤、局所刺激剤、抗酸化剤、ビタミン類等が挙げられる。
<Medicinal ingredient>
The scalp external preparation can contain various medicinal ingredients in addition to the above-described hair growth and hair nourishing ingredients. Examples of medicinal ingredients include antibacterial agents, anti-inflammatory agents, moisturizers, keratolytic agents, antiseborrheic agents, local stimulants, antioxidants, vitamins and the like.
抗菌剤としては、イソプロピルメチルフェノール、塩化ベンザルコニウム、オクトピロックス、感光色素101、感光色素201、クロルヘキシジン、サリチル酸、ジンクピリチオン、ソルビン酸カリウム、ヒノキチオール、フェノール等が挙げられる。このうち、イソプロピルメチルフェノール、塩化ベンザルコニウム、ピロクトンオーラミン、ジンクピリチオン、ヒノキチオールが好ましい。 Antibacterial agents include isopropylmethylphenol, benzalkonium chloride, octopirox, photosensitive dye 101, photosensitive dye 201, chlorhexidine, salicylic acid, zinc pyrithione, potassium sorbate, hinokitiol, phenol and the like. Of these, isopropylmethylphenol, benzalkonium chloride, piroctone auramine, zinc pyrithione and hinokitiol are preferable.
抗炎症剤としては、甘草エキス、グリチルリチン酸及びその誘導体、グリチルレチン酸及びその誘導体、脂溶性グリチルレチン酸類、アズレン、グアイアズレン、ジフェンヒドラミン等の抗ヒスタミン剤、酢酸ヒドロコルチゾン、プレドニゾロン、オウゴンエキス、カミツレエキス、クマザサエキス、シラカバエキス、ゼニアオイエキス、桃葉エキス、セイヨウノコギリソウエキス、キキョウエキス、ビワ葉エキス、ボダイジュエキス等が挙げられる。このうち、甘草エキス、グリチルリチン酸及びその誘導体、グリチルレチン酸及びその誘導体、アズレン、グアイアズレン、オウゴンエキス、カミツレエキス、クマザサエキス、シラカバエキス、ゼニアオイエキス、桃葉エキス、セイヨウノコギリソウエキスが好ましい。 Anti-inflammatory agents include licorice extract, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, fat-soluble glycyrrhetinic acids, antihistamines such as azulene, guaiazulene and diphenhydramine, hydrocortisone acetate, prednisolone, ougon extract, chamomile extract, kumazasa extract, birch extract Examples include extract, mallow extract, peach leaf extract, yarrow extract, fennel extract, loquat leaf extract, bodaiju extract and the like. Among these, licorice extract, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, azulene, guaiazulene, urgonum extract, chamomile extract, columbum extract, birch extract, mallow extract, peach leaf extract, and yarrow extract are preferred.
保湿剤としては、オトギリソウエキス、オーツ麦エキス、桔梗エキス、可溶性コラーゲン、グリセリン、コンドロイチン硫酸、チューベロースポリサッカライド、プロピレングリコール、冬虫夏草エキス、延命草エキス、オオムギエキス、オレンジエキス、ブドウエキス、海藻エキス、ボタンピエキス、ジオウエキス、デュークエキス、マイカイ花エキス、ボタンピエキス、ヨクイニンエキス等が挙げられる。このうち、オトギリソウエキス、オーツ麦エキス、グリセリン、チューベロースポリサッカライド、冬虫夏草エキス、延命草エキス、オオムギエキス、ブドウエキス、プロピレングリコール、桔梗エキス、ヨクイニンエキスが好ましい。 As moisturizers, hypericum extract, oat extract, bellflower extract, soluble collagen, glycerin, chondroitin sulfate, tuberose polysaccharide, propylene glycol, cordyceps extract, life-extension grass extract, barley extract, orange extract, grape extract, seaweed extract , Button pi extract, diau extract, duke extract, maikai flower extract, button pi extract, yokuinin extract and the like. Among these, hypericum extract, oat extract, glycerin, tuberose polysaccharide, cordyceps extract, life-extending grass extract, barley extract, grape extract, propylene glycol, bellflower extract, and yokuinin extract are preferable.
角質溶解剤としてはアスピリン等が挙げられる。 Examples of keratolytic agents include aspirin.
抗脂漏剤としては、イオウ、レシチン、カシュウエキス、チオキソロン等が挙げられる。 Anti-seborrheic agents include sulfur, lecithin, cachet extract, thioxolone and the like.
局所刺激剤としては、カンファー、ノニル酸ワニリルアミド、オランダガラシ、サンショウエキス、ハッカ油、l-メントール、ワサビ大根エキス等が挙げられる。このうち、カンファーが好ましい。 Examples of the local stimulant include camphor, nonylic acid vanillylamide, Dutch pepper, salamander extract, peppermint oil, l-menthol, horseradish radish extract and the like. Of these, camphor is preferred.
抗酸化剤としては、紅茶エキス、茶エキス、エイジツエキス、黄杞エキス、ビタミンC及びその誘導体、エリソルビン酸、没食子酸プロピル、ジブチルヒドロキシトルエン等が挙げられる。 Examples of the antioxidant include black tea extract, tea extract, age extract, jaundice extract, vitamin C and its derivatives, erythorbic acid, propyl gallate, dibutylhydroxytoluene and the like.
これら薬効成分の含有量は、合計で頭皮外用剤中の0.001〜20質量%が好ましく、0.01〜8質量%がより好ましい。 The total content of these medicinal ingredients is preferably 0.001 to 20% by mass, more preferably 0.01 to 8% by mass in the scalp external preparation.
<コンディショニング成分>
頭皮外用剤は、毛髪への適用に好適なコンディショニング成分を含むことができる。コンディショニング成分は、通常は、頭皮外用剤に溶解又は分散可能なポリマー又はオイル類である。コンディショニング成分を用いる場合、その含有量は、頭皮外用剤中の0.01〜30質量%、好ましくは0.1〜20質量%、より好ましくは0.1〜10質量%である。
<Conditioning ingredients>
The scalp external preparation can contain a conditioning component suitable for application to the hair. The conditioning component is usually a polymer or oil that can be dissolved or dispersed in the scalp external preparation. When using a conditioning component, the content is 0.01-30 mass% in a scalp external preparation, Preferably it is 0.1-20 mass%, More preferably, it is 0.1-10 mass%.
頭皮外用剤に配合される好適なコンディショニング成分としては、カチオン性ポリマー、シリコーン類、有機コンディショニングオイル等、及びこれらの組み合わせが挙げられる。更には、これら以外に水性界面活性剤中に分散液体粒子を形成するコンディショニング剤が挙げられる。 Suitable conditioning components blended into the scalp external preparation include cationic polymers, silicones, organic conditioning oils, and combinations thereof. Furthermore, the conditioning agent which forms a dispersion liquid particle in aqueous | water-based surfactant other than these is mentioned.
・カチオン性ポリマー
カチオン性ポリマーとは、カチオン基又はカチオン基にイオン化され得る基を有するポリマーをいい、全体としてカチオン性となる両性ポリマーも含まれ、更には、前述の増粘剤として用いられるカチオン性ポリマーも含む。すなわち、カチオン性ポリマーとしては、ポリマー鎖の側鎖にアミノ基又はアンモニウム基を含むか、又はジアリル4級アンモニウム塩を構成単位として含む水溶液のもの、例えばカチオン化セルロース誘導体、カチオン性澱粉、カチオン化グアーガム誘導体、ジアリル4級アンモニウム塩の重合体又は共重合体、4級化ポリビニルピロリドン誘導体等が挙げられる。これらのうち、特に頭皮外用剤使用時の柔らかさ、滑らかさ及び指の通り易さ、乾燥時のまとまり易さ及び保湿性という効果及び頭皮外用剤の安定性の点から、ジアリル4級アンモニウム塩を構成単位として含むポリマー、4級化ポリビニルピロリドン誘導体、カチオン化セルロース誘導体が好ましく、ジアリル4級アンモニウム塩の重合体又は共重合体、カチオン化セルロース誘導体がより好ましい。
Cationic polymer The cationic polymer refers to a polymer having a cationic group or a group that can be ionized into a cationic group, including an amphoteric polymer that becomes cationic as a whole, and further includes a cation used as the aforementioned thickener. Also includes a functional polymer. That is, as the cationic polymer, an aqueous solution containing an amino group or an ammonium group in the side chain of the polymer chain or containing a diallyl quaternary ammonium salt as a structural unit, such as a cationized cellulose derivative, a cationic starch, a cationization Examples include guar gum derivatives, diallyl quaternary ammonium salt polymers or copolymers, and quaternized polyvinylpyrrolidone derivatives. Among these, diallyl quaternary ammonium salts are particularly advantageous in terms of softness, smoothness and ease of fingering when using an external preparation for scalp, ease of grouping and moisture retention during drying, and stability of the external preparation for scalp. , A quaternized polyvinylpyrrolidone derivative and a cationized cellulose derivative are preferred, and a diallyl quaternary ammonium salt polymer or copolymer, and a cationized cellulose derivative are more preferred.
ジアリル4級アンモニウム塩の重合体又は共重合体の具体例としては、ジメチルジアリルアンモニウムクロリド重合体(ポリクオタニウム-6、例えばマーコート100;Nalco社)、ジメチルジアリルアンモニウムクロリド/アクリル酸共重合体(ポリクオタニウム-22、例えばマーコート280、同295;Nalco社)、ジメチルジアリルアンモニウムクロリド/アクリル酸アミド共重合体(ポリクオタニウム-7、例えばマーコート550;Nalco社)等が挙げられる。 Specific examples of the polymer or copolymer of diallyl quaternary ammonium salt include dimethyldiallylammonium chloride polymer (polyquaternium-6, such as Marquat 100; Nalco), dimethyldiallylammonium chloride / acrylic acid copolymer (polyquaternium- 22, for example, Marquat 280, 295; Nalco), dimethyldiallylammonium chloride / acrylic acid amide copolymer (polyquaternium-7, for example, Marquat 550; Nalco), and the like.
4級化ポリビニルピロリドン誘導体の具体例としては、ビニルピロリドン(VP)とメタクリル酸ジメチルアミノエチルの共重合体と硫酸ジエチルから得られる4級アンモニウム塩〔ポリクオタニウム-11、例えばガフコート734、同755、同755N(以上、アイエスピー・ジャパン社)〕等が挙げられる。 Specific examples of the quaternized polyvinyl pyrrolidone derivative include a quaternary ammonium salt obtained from a copolymer of vinyl pyrrolidone (VP) and dimethylaminoethyl methacrylate and diethyl sulfate [Polyquaternium-11 such as Guffcoat 734, 755, 755N (above, IS Japan Co., Ltd.)].
カチオン化セルロース誘導体の具体例としては、ヒドロキシエチルセルロースに塩化グリシジルトリメチルアンモニウムを付加して得られる4級アンモニウム塩の重合体〔ポリクオタニウム-10、例えばレオガードG、同GP(以上、ライオン社)、ポリマーJR-125、同JR-400、同JR-30M、同LR-400、同LR-30M(以上、Amerchol社)〕、ヒドロキシエチルセルロース/ジメチルジアリルアンモニウムクロリド共重合体〔ポリクオタニウム-4、例えばセルコートH-100、同L-200(以上、ナショナルスターチアンドケミカル社)〕等が挙げられる。 Specific examples of the cationized cellulose derivative include polymers of quaternary ammonium salts obtained by adding glycidyltrimethylammonium chloride to hydroxyethyl cellulose [Polyquaternium-10, such as Leogard G, GP (above, Lion), polymer JR -125, JR-400, JR-30M, LR-400, LR-30M (above Amerchol)], hydroxyethylcellulose / dimethyldiallylammonium chloride copolymer [Polyquaternium-4, eg Cellcoat H-100 , L-200 (National Starch and Chemical Co., Ltd.)] and the like.
・シリコーン類
シリコーン類としては、例えば以下に示すものが挙げられる。
(1) ジメチルポリシロキサン
R2(CH3)2SiO−[(CH3)2SiO]m−Si(CH3)2R2
〔式中、R1はメチル基又はヒドロキシ基を示し、mは1〜20,000の数を示す。〕
-Silicones Examples of silicones include those shown below.
(1) Dimethylpolysiloxane R 2 (CH 3 ) 2 SiO — [(CH 3 ) 2 SiO] m —Si (CH 3 ) 2 R 2
[Wherein, R 1 represents a methyl group or a hydroxy group, and m represents a number of 1 to 20,000. ]
ジメチルポリシロキサンの分散粒子の平均粒径は100μm未満が好ましく、更には50μm以下、特に4μm以下、とりわけ2μm以下であることが好ましい。また、平均粒径は、0.1μm以上であることが、使用感やコンディショニング効果の点で好ましい。 The average particle diameter of the dispersed particles of dimethylpolysiloxane is preferably less than 100 μm, more preferably 50 μm or less, particularly 4 μm or less, and particularly preferably 2 μm or less. In addition, the average particle size is preferably 0.1 μm or more from the viewpoint of usability and conditioning effect.
このようなジメチルポリシロキサンとしては、例えば、一般式(10)のmが300〜6,500のジメチルポリシロキサン油を60質量%含み、平均粒径が0.8μmである東レ・ダウコーニング社の「シリコーンCF2450」又はmが300〜6,500のジメチルポリシロキサン油を50質量%含み、平均粒径が50μmである東レ・ダウコーニング社の「シリコーンCF2460」として市販されているものを使用することができる。 Examples of such dimethylpolysiloxane include “Silicone CF2450” manufactured by Toray Dow Corning Co., Ltd., which contains 60% by mass of dimethylpolysiloxane oil of general formula (10) having an m of 300 to 6,500 and an average particle diameter of 0.8 μm. Or “Silicon CF2460” manufactured by Toray Dow Corning Co., which contains 50% by mass of dimethylpolysiloxane oil having an m of 300 to 6,500 and an average particle size of 50 μm, can be used.
(2) アミノ変性シリコーン
各種のアミノ変性シリコーンが使用できるが、特に平均分子量が約3,000〜100,000の、アモジメチコーン(Amodimethicone)の名称でCTFA辞典(米国,Cosmetic Ingredient Dictionary)第3版中に記載されているものが好ましい。市販品としては、SM 8704C(東レ・ダウコーニング社)、DC 929(ダウ・コーニング社)、KT 1989(GE東芝シリコーン社)、8500 Conditioning Agent、DOW CORNING TORAY SS-3588、DOW CORNING TORAY SILSTYLE 104(東レ・ダウコーニング社)等が挙げられる。
(2) Amino-modified silicone Various amino-modified silicones can be used, but are described in the third edition of the CTFA Dictionary (US, Cosmetic Ingredient Dictionary) under the name of Amodimethicone, particularly with an average molecular weight of about 3,000-100,000. Is preferred. Commercially available products include SM 8704C (Toray Dow Corning), DC 929 (Dow Corning), KT 1989 (GE Toshiba Silicone), 8500 Conditioning Agent, DOW CORNING TORAY SS-3588, DOW CORNING TORAY SILSTYLE 104 ( Toray Dow Corning).
(3) その他のシリコーン類
上記以外に、ポリエーテル変性シリコーン、メチルフェニルポリシロキサン、脂肪酸変性シリコーン、アルコール変性シリコーン、アルコキシ変性シリコーン、エポキシ変性シリコーン、フッ素変性シリコーン、環状シリコーン、アルキル変性シリコーン等が挙げられる。
(3) Other silicones Other than the above, polyether modified silicone, methylphenyl polysiloxane, fatty acid modified silicone, alcohol modified silicone, alkoxy modified silicone, epoxy modified silicone, fluorine modified silicone, cyclic silicone, alkyl modified silicone, etc. It is done.
・有機コンディショニングオイル
有機コンディショニングオイルとしては、例えば、炭化水素油、ポリオレフィン、脂肪酸エステルが挙げられる。
Organic conditioning oil Examples of the organic conditioning oil include hydrocarbon oil, polyolefin, and fatty acid ester.
炭化水素油としては、炭素数10以上の炭化水素油、例えば環状炭化水素や直鎖脂肪族炭化水素(飽和又は不飽和)や分枝鎖肪族炭化水素(飽和又は不飽和)が挙げられ、これらのポリマーや混合物も含まれる。直鎖炭化水素油は、好ましくは炭素数12〜19である。分枝鎖炭化水素油は、炭化水素ポリマーを含み、通常炭素数19を超える。 Examples of the hydrocarbon oil include hydrocarbon oils having 10 or more carbon atoms, such as cyclic hydrocarbons, straight chain aliphatic hydrocarbons (saturated or unsaturated) and branched chain aliphatic hydrocarbons (saturated or unsaturated), These polymers and mixtures are also included. The linear hydrocarbon oil preferably has 12 to 19 carbon atoms. Branched chain hydrocarbon oils contain hydrocarbon polymers and usually have more than 19 carbon atoms.
ポリオレフィンとしては、液状ポリオレフィン、更には液状ポリ-α-オレフィン、特に水素化液状ポリ-α-オレフィンが好ましい。ここで用いられるポリオレフィンは、C4〜C14、好ましくはC6〜C12のオレフィンモノマーを重合して調製する。 As the polyolefin, liquid polyolefin, further liquid poly-α-olefin, particularly hydrogenated liquid poly-α-olefin is preferable. The polyolefin used here is prepared by polymerizing C 4 to C 14 , preferably C 6 to C 12 olefin monomers.
脂肪族エステルとしては、例えば、脂肪酸とアルコールから誘導される炭化水素鎖を有するエステル(例えば、モノエステル、多価アルコールエステル、ジ−及びトリカルボン酸エステル)が挙げられる。これら脂肪族エステルの炭化水素基は、更にアミド基、アルコキシ基、ポリオキシアルキレン基等の他の相溶性官能部を有していてもよく、またそれらに共有結合していてもよい。好ましい脂肪族エステルの具体例としては、ミリスチン酸イソプロピル、ミリスチン酸オクチルドデシル等が挙げられる。 Examples of the aliphatic ester include esters having a hydrocarbon chain derived from a fatty acid and an alcohol (for example, monoester, polyhydric alcohol ester, di- and tricarboxylic acid ester). The hydrocarbon group of these aliphatic esters may further have other compatible functional parts such as an amide group, an alkoxy group, a polyoxyalkylene group, and may be covalently bonded to them. Specific examples of preferable aliphatic esters include isopropyl myristate, octyldodecyl myristate, and the like.
<極性油剤>
頭皮外用剤には、上記コンディショニング成分以外に、有効成分を可溶化して頭皮への浸透を促進すると共に、感触と安定性を向上する極性油剤を加えることができる。極性油剤としては、高級アルコール、及び脂肪酸グリセリドが挙げられる。高級アルコールとしては、ラウリルアルコール、ステアリルアルコール、オレイルアルコール、イソステアリルアルコール、セトステアリルアルコール等が挙げられる。脂肪酸グリセリドとしては、炭素数8〜18の脂肪酸のモノグリセリド、ジグリセリド及びトリグリセリドが挙げられる。これらのうち、有効成分の結晶化を防ぎ、頭皮の脂質からなる油膜を溶解し、皮膚浸透を促進する観点から、20℃において液体で、かつ100mPa・s以下、特に50mPa・s以下であるものが好ましい。
<Polar oil agent>
In addition to the conditioning ingredients described above, the scalp external preparation can be added with a polar oil that solubilizes the active ingredient to promote penetration into the scalp and improves the feel and stability. Examples of polar oils include higher alcohols and fatty acid glycerides. Examples of the higher alcohol include lauryl alcohol, stearyl alcohol, oleyl alcohol, isostearyl alcohol, cetostearyl alcohol and the like. Examples of fatty acid glycerides include monoglycerides, diglycerides and triglycerides of fatty acids having 8 to 18 carbon atoms. Of these, those that are liquid at 20 ° C and less than 100 mPa · s, especially less than 50 mPa · s, from the viewpoint of preventing the crystallization of active ingredients, dissolving the oil film consisting of lipids on the scalp, and promoting skin penetration Is preferred.
極性油剤の含有量は、有効成分の浸透促進及び感触向上の観点から、頭皮外用剤中の0.01〜5質量%、特に0.1〜2質量%が好ましい。 The content of the polar oil agent is preferably 0.01 to 5% by mass, particularly 0.1 to 2% by mass in the scalp external preparation, from the viewpoint of promoting penetration of the active ingredient and improving touch.
<酸化防止剤>
頭皮外用剤には、更に酸化防止剤を含有させることができる。酸化防止剤としては、ビタミンC及びその誘導体、エリソルビン酸、没食子酸プロピル、BHT(ジ-n-ブチルヒドロキシトルエン)、BHA(ブチルヒドロキシアニソール)等が挙げられる。これらは、頭皮外用剤の保存安定性向上に効果的で、特に、高温(例えば50℃)での保存安定性向上に効果がある。酸化防止剤の含有量は、頭皮外用剤中の0.01〜0.5重量%、特に0.05〜0.3重量%が好ましい。
<Antioxidant>
The scalp external preparation can further contain an antioxidant. Examples of the antioxidant include vitamin C and its derivatives, erythorbic acid, propyl gallate, BHT (di-n-butylhydroxytoluene), BHA (butylhydroxyanisole) and the like. These are effective in improving the storage stability of the scalp external preparation, and are particularly effective in improving the storage stability at high temperatures (for example, 50 ° C.). The content of the antioxidant is preferably 0.01 to 0.5% by weight, particularly 0.05 to 0.3% by weight in the scalp external preparation.
<その他任意成分・剤型>
頭皮外用剤には、上記成分以外に、通常の化粧品分野で用いられる成分を、目的に応じて加えることができる。このような任意成分としては、無機アルカリ、油脂、アミノ酸誘導体、タンパク質誘導体、キレート剤、防腐剤、紫外線吸収剤、pH調整剤、前述の植物抽出物以外の植物抽出物、香料等が挙げられる。
<Other optional ingredients and dosage forms>
In addition to the above-described components, components for use in normal cosmetics can be added to the scalp external preparation according to the purpose. Examples of such optional components include inorganic alkalis, fats and oils, amino acid derivatives, protein derivatives, chelating agents, preservatives, ultraviolet absorbers, pH adjusters, plant extracts other than the aforementioned plant extracts, and fragrances.
頭皮外用剤は、頭皮に効果的に塗布される剤型が好ましく、通常は、液剤を主体とし、ローションやヘアトニックが代表的なものであり、噴射剤と共にエアゾール剤としても使用できる。また、クリーム、ジェル、ワックス、洗い流さないタイプのヘアトリートメント、ヘアフォーム剤、ヘアスプレー剤等の剤型で使用することもできる。 The scalp external preparation is preferably a dosage form that is effectively applied to the scalp. Usually, it is mainly composed of a liquid agent, and lotions and hair tonics are typical, and it can be used as an aerosol together with a propellant. Moreover, it can also be used in dosage forms such as creams, gels, waxes, non-washing hair treatments, hair foams, hair sprays and the like.
<使用方法>
本発明のうねり改善剤は、頭皮に浸透し毛根の完成層(安田利顕監修、須藤武雄・瀬田季茂共著 毛髪科学図説 1978年 P.13)に作用することにより、毛髪うねり改善剤塗布後に生えてくる毛髪のうねりを緩和する。それゆえ、本発明のうねり改善剤を含有する頭皮外用剤の使用方法としては、頭皮に塗布した後、洗い流さず放置することが必要である。
<How to use>
The swell improver of the present invention penetrates the scalp and acts on the completed root of the hair root (supervised by Toshiaki Yasuda, Takeo Sudo and Kiyoshi Seta, 1978, P.13). Alleviates the undulation of the growing hair. Therefore, as a method of using the scalp external preparation containing the swell improving agent of the present invention, it is necessary to leave it without being washed off after being applied to the scalp.
十分なうねり緩和効果を得るには、頭皮外用剤を頭皮に塗布した後、少なくとも3時間は洗い流さず放置することが好ましく、更には6時間以上、特に8時間以上放置することが望ましい。一方、頭皮を清潔に保つ観点から、頭皮外用剤を頭皮に塗布した後の放置時間は、72時間以下とすることが好ましく、更には48時間以下、特に24時間以下とすることが好ましい。 In order to obtain a sufficient swell mitigating effect, it is preferable that the external preparation for scalp is applied to the scalp and then left unwashed for at least 3 hours, more preferably 6 hours or more, particularly 8 hours or more. On the other hand, from the viewpoint of keeping the scalp clean, the standing time after applying the scalp external preparation to the scalp is preferably 72 hours or less, more preferably 48 hours or less, and particularly preferably 24 hours or less.
本発明の毛髪うねり改善剤を含有する頭皮外用剤は、洗髪直後に頭皮に塗布するのが好ましい。洗髪直後の頭皮は湿った状態であるため、洗髪前の乾燥状態の頭皮に比較して、頭皮外用剤が容易に頭皮へ浸透しやすく、その結果、毛髪うねり改善効果が向上する。 The scalp external preparation containing the hair swell improving agent of the present invention is preferably applied to the scalp immediately after washing. Since the scalp immediately after shampooing is in a moist state, the scalp external preparation easily penetrates into the scalp as compared with the dry scalp before shampooing, and as a result, the effect of improving hair swell is improved.
洗髪後、時間の経過と共に頭皮は徐々に乾燥した状態に戻るため、頭皮外用剤を頭皮に塗布するタイミングは、洗髪後できるだけ早い方が効果的である。具体的には、洗髪後1時間以内、より好ましくは30分以内、更に好ましくは15分以内に頭皮外用剤を頭皮に塗布することが望ましい。 Since the scalp gradually returns to a dry state as time passes after washing, it is more effective to apply the scalp external preparation to the scalp as soon as possible after washing the hair. Specifically, it is desirable to apply the scalp external preparation to the scalp within 1 hour, more preferably within 30 minutes, and even more preferably within 15 minutes after washing the hair.
本発明においては、洗髪後タオルドライした直後に頭皮外用剤を頭皮に塗布することにより、毛髪うねり改善効果を更に向上することができる。毛髪は束の状態で水に濡れた場合、毛髪自体の重量を超える量の水を保持している。それゆえ、洗髪後タオルドライする前に頭皮外用剤を頭皮に塗布すると、頭皮外用剤の濃度が毛髪の束に保持されている過剰な水で薄まり、頭皮上に残留する頭皮外用剤の量が低下する。洗髪後タオルドライすることにより、毛髪の束に保持されている過剰な水が取り除かれるため、頭皮に塗布した頭皮外用剤は薄まることなく頭皮上に残留し、毛髪うねり改善効果が向上する。 In the present invention, the hair swell improving effect can be further improved by applying the scalp external preparation to the scalp immediately after towel drying after washing the hair. When the hair gets wet with water in the form of a bundle, it retains an amount of water that exceeds the weight of the hair itself. Therefore, if the scalp external preparation is applied to the scalp before washing with towel after washing the hair, the concentration of the scalp external preparation will be diluted with excess water held in the hair bundle, and the amount of the scalp external preparation remaining on the scalp will be reduced. descend. By drying the towel after washing the hair, excess water held in the hair bundle is removed, so that the external preparation for scalp applied to the scalp remains on the scalp without diluting, and the effect of improving hair swell is improved.
上記の観点から、洗髪後タオルドライを行うことが好ましいが、頭皮外用剤の頭皮への浸透の観点からは、洗髪後できるだけ早いタイミングで、頭皮が湿っている状態で頭皮外用剤を頭皮に塗布することが望ましい。従って、洗髪・タオルドライ後1時間以内、より好ましくは30分以内、更に好ましくは15分以内に頭皮外用剤を頭皮に塗布することが望ましい。 From the above viewpoint, it is preferable to perform towel drying after washing the hair, but from the viewpoint of penetration of the scalp external preparation into the scalp, apply the scalp external preparation to the scalp while the scalp is wet as soon as possible after washing the hair. It is desirable to do. Therefore, it is desirable to apply the scalp external preparation to the scalp within 1 hour, more preferably within 30 minutes, and even more preferably within 15 minutes after washing and towel drying.
本発明の毛髪うねり改善剤を含有する頭皮外用剤は、頭皮に塗布後、頭皮をマッサージすることにより、毛髪うねり改善効果を向上させることができる。 The scalp external preparation containing the hair swell improving agent of the present invention can improve the hair swell improving effect by massaging the scalp after application to the scalp.
頭皮外用剤を頭皮に塗布した後、頭皮を物理的にマッサージすることにより、塗布された頭皮外用剤が頭皮上で均一にのび拡がると共に、頭皮が物理的に刺激され、頭皮外用剤の頭皮への浸透も促進される。その結果、毛髪うねり改善効果が向上する。 After applying the scalp external preparation to the scalp, the scalp is physically massaged so that the applied scalp externally spreads evenly on the scalp and the scalp is physically stimulated to the scalp of the external scalp preparation. Penetration is also promoted. As a result, the hair swell improvement effect is improved.
頭皮マッサージの具体的な方法としては、頭皮を傷つけない櫛やブラシなどの道具を用いて、頭皮をなでる、こする、たたくなどの方法が挙げられる。また、指で直接、あるいは効率的にマッサージするための手袋などを用いて頭皮をなでる、こする、たたく、もむなどの方法が挙げられる。 Specific methods of scalp massage include stroking, rubbing and tapping the scalp using tools such as combs and brushes that do not damage the scalp. In addition, there are methods such as stroking, rubbing, tapping, and mumming the scalp directly with fingers or using gloves for efficient massage.
本発明の毛髪うねり改善剤を含有する頭皮外用剤は、頭皮上に留まり更に頭皮内に浸透することにより、毛髪うねり改善効果が発現する。頭皮上の頭皮外用剤は、頭皮に浸透する以外に皮脂や汗で流されてしまうため、頭皮上に残留する頭皮外用剤の量は経時的に低下する。従って、頭皮外用剤の使用頻度を高くすることにより、継続的な毛髪うねり改善効果を向上させることができる。 The scalp external preparation containing the hair swell improving agent of the present invention stays on the scalp and further penetrates into the scalp, thereby exhibiting a hair swell improving effect. Since the scalp external preparation on the scalp is washed away by sebum and sweat in addition to permeating the scalp, the amount of the scalp external preparation remaining on the scalp decreases with time. Therefore, the continuous hair waviness improvement effect can be improved by increasing the use frequency of the scalp external preparation.
具体的には、二日に一回以上、より好ましくは一日一回以上、更に好ましくは一日二回、頭皮外用剤を頭皮に塗布することが望ましい。 Specifically, it is desirable to apply the scalp external preparation to the scalp at least once every two days, more preferably at least once a day, and even more preferably twice a day.
更に、本発明の毛髪うねり改善剤を含有する頭皮外用剤は、毛髪うねり改善剤が頭皮に浸透し毛根の完成層に作用することにより、頭皮外用剤の塗布後に生える毛髪のうねり形状が緩和し、毛髪うねり改善効果が発現する。従って、毛髪うねり改善効果は、毛髪の成長に伴って徐々に認知されるようになる。具体的には、少なくとも2〜3cm毛髪が成長すると、毛髪うねり改善効果が認知され始める。毛髪の成長速度は約0.4mm/日であるため、2ヶ月以上継続処理することにより、毛髪うねり改善効果の認知されやすさを向上することができる。 Furthermore, the scalp external preparation containing the hair swell improving agent of the present invention has a hair swell improving agent that permeates into the scalp and acts on the finished layer of the hair root. , Hair undulation improvement effect is expressed. Therefore, the hair undulation improving effect is gradually recognized as the hair grows. Specifically, when hair of at least 2 to 3 cm grows, the effect of improving hair swell starts to be recognized. Since the hair growth rate is about 0.4 mm / day, it is possible to improve the ease of recognizing the effect of improving hair swell by continuous treatment for 2 months or more.
(被験試料)
ユーカリ抽出液BGF(丸善製薬社)を3質量%となるよう水と混合し、被験試料とした。
(Test sample)
Eucalyptus extract BGF (Maruzen Pharmaceutical Co., Ltd.) was mixed with water so as to be 3% by mass, and used as a test sample.
(毛髪処理とサンプリング)
41〜56歳の健康女性10名に、1日2回3gずつ、頭皮全体に被験試料を塗布してもらった。開始時と6ヶ月後に、頭頂部周辺より毛髪を、根元からカットした。サンプリングした毛髪は、頭皮面積にして縦7mm×横7mmの範囲の全ての毛髪であり、1人あたり40〜120本、平均70本前後である。
(Hair treatment and sampling)
Ten healthy women aged 41 to 56 years applied 3 g of the test sample to the entire scalp twice a day. At the start and 6 months later, the hair was cut from the root around the top of the head. The sampled hairs are all hairs in the scalp area in the range of 7 mm long x 7 mm wide, with 40 to 120 hairs per person, average around 70 hairs.
(形状の測定方法)
コンディショニング剤を含まないプレーンなシャンプーで洗髪し、自然乾燥後、サンプリングを行った。カールの形状測定には、半径が1mmずつ異なる同心円(半径1mm〜200mmで、1mm間隔)を描いた透明なフィルムを毛髪上に乗せ、根元から4cm、3cm、2cm及び1cmの部分について、毛髪の曲率半径を読み取り、その逆数(曲率)を求めた。ただし、曲率が0.05(単位:cm-1)より小さい(半径20cmの円に相当する円弧よりも真直ぐ)な場合には、その曲率を0.05と近似した。それぞれの毛髪について上記4部分における曲率の平均値を求め、その逆数をその毛髪のカール半径とした。7mm×7mmの部分からカットしたすべての毛髪について上記部分の曲率を測定し、その平均値を求め、平均値の逆数を平均カール半径とした。
下記式に基づいて、6ヶ月後と開始時の平均カール半径の比を「うねり改善度」として表した。
(Shape measurement method)
The hair was washed with a plain shampoo containing no conditioning agent, sampled after being dried naturally. To measure the shape of the curl, place a transparent film with concentric circles (radius 1 mm to 200 mm, 1 mm interval) with different radii by 1 mm on the hair, and 4 cm, 3 cm, 2 cm, and 1 cm from the root, The radius of curvature was read and its reciprocal (curvature) was determined. However, when the curvature was smaller than 0.05 (unit: cm −1 ) (straighter than an arc corresponding to a circle with a radius of 20 cm), the curvature was approximated to 0.05. For each hair, the average value of curvature in the above four parts was determined, and the reciprocal thereof was taken as the curl radius of the hair. The curvature of the above portion was measured for all hairs cut from a 7 mm × 7 mm portion, the average value was obtained, and the reciprocal of the average value was taken as the average curl radius.
Based on the following formula, the ratio of the average curl radius after 6 months and at the start was expressed as “swell improvement”.
また、毛髪カール半径が4cmより小さい毛髪をうねり毛と定義し、サンプリングした全毛髪本数に対するうねり毛本数の割合(うねり毛存在比)(単位:%)を調べた。6ヶ月後と開始時のうねり毛存在比の差を「うねり毛減少率」として表した。 Further, hair having a hair curl radius of less than 4 cm was defined as waviness, and the ratio of the number of waviness to the total number of sampled hairs (ratio of waviness) (unit:%) was examined. The difference in the waviness ratio after 6 months and at the start was expressed as “waviness reduction ratio”.
結果は表1に示すとおりであり、被験者全員において平均カール半径の増大、すなわちうねりの改善が認められた。また、被験者全員において正のうねり毛減少率、すなわちうねり毛の減少が認められた。 The results are as shown in Table 1. All subjects showed an increase in average curl radius, that is, improvement in undulation. Moreover, a positive waviness reduction rate, that is, a reduction in waviness was observed in all the subjects.
被験試料として、ユーカリ抽出液の入っていない水のみの剤を用い、実施例とは別の41〜56歳の健康女性10名に、実施例と同様の試験を行った。
結果は表2に示すとおりであり、被験者全員において平均カール半径の変化率は±10%の範囲内にあり、うねりの変化は認められなかった。また、被験者全員においてうねり毛減少率は±5%の範囲内にあり、うねり毛の割合の変化は認められなかった。
As a test sample, a water-only agent containing no eucalyptus extract was used, and 10 healthy women aged 41 to 56 different from the examples were tested in the same manner as in the examples.
The results are as shown in Table 2, and the change rate of the average curl radius was within a range of ± 10% in all the subjects, and no change in swell was observed. In all the subjects, the waviness reduction rate was in the range of ± 5%, and no change in the proportion of waviness was observed.
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