JP5268519B2 - Analysis equipment - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an analyzer equipped with a rotation driving device capable of executing stable rocking treatment, even if deformations, such as, abrasion of a component are produced. <P>SOLUTION: This analyzer is provided with a memory (122) for storing the rocking frequency of the second driving means (D2), in correspondence with a set value, and a control device (123) for reading out a set value, necessary for imparting rocking in a target frequency to an analysis device (1) and executing a rocking treatment routine to be supplied to the second driving means (D2). The control device (123) is constituted so as to measure the rocking frequency, by supplying a set value for learning to the second driving means (D2), and to executes a load fluctuation learning routine for updating a memory (122) content, in a direction where the fluctuation &Delta;f of the rocking frequency is reduced, corresponding to the measured value. <P>COPYRIGHT: (C)2010,JPO&amp;INPIT

Description

  The present invention relates to an analyzer for analyzing an analysis device containing a sample solution collected from a living organism or the like by transferring it toward a measurement chamber by centrifugal force.

  Conventionally, as a method for analyzing a liquid collected from a living organism or the like, a method for analyzing using a device for analysis in which a liquid channel is formed is known. The analytical device can control the fluid using a rotating device, and utilizes centrifugal force to dilute the sample liquid, measure the solution, separate the solid component, transfer and distribute the separated fluid, Since a solution and a reagent can be mixed, various biochemical analyzes can be performed.

  The analytical device 50 described in Patent Document 1 that transfers a solution using centrifugal force injects a sample liquid as a specimen into the measuring chamber 52 from an injection port 51 using an insertion instrument such as a pipette as shown in FIG. After the sample liquid is held by the capillary force of the measuring chamber 52, the sample liquid is transferred to the separation chamber 53 by the rotation of the analyzing device. An analytical device that uses such centrifugal force as a power source for liquid feeding can be used as a preferred shape because microchannels for liquid feeding control can be arranged radially by using a disk shape, and no wasted area is generated. It is done.

The sample solution and the diluting solution are mixed and stirred by accelerating / decelerating or rotating forward and backward in the same rotation direction of the turntable on which the analysis device 50 is set.
Although the analysis device as in Patent Document 1 is not handled, the centrifuge of Patent Document 2 is rotationally driven by a motor 302 in a hole 301 formed in a substrate 300 as shown in FIG. A technique for vibrating the substrate 300 by inserting an eccentric cam 303 is described.
JP 7-500910 Gazette Japanese Patent No. 2866404

  However, in the configuration of Patent Document 1, the inertial force of the analytical device and the response of the driving device are problems, and sufficient acceleration for mixing and stirring cannot be obtained in a short time. What is needed is the current situation.

This is particularly noticeable in the case of mixing a very small amount of fluid, and there is a case where mixing and stirring are insufficient even if sufficient time is spent.
Therefore, a rotation drive device 106 shown in FIG. 21 is conceivable, which can cause the analyzing device to reciprocate left and right in a predetermined amplitude range and cycle of the analyzing device at a predetermined stop position.

  As shown in FIG. 21, the turntable 101 on which the analysis device is set is attached to the output shaft of the first motor 71a of the first drive means D1, and by operating the first motor 71a, The analytical device can be continuously rotated to the right or continuously to the left.

  The chassis 75 to which the first motor 71a is attached has a second motor 72a of the second drive means D2 that selectively engages the first drive means D1 and reciprocates the analyzing device; A third motor 73a of the third driving means D3 that is relatively moved to a position where the first driving means D1 and the second driving means D2 are engaged and a position where they are not engaged is attached. A support shaft 78 is attached to a support table 77 that is slidably attached to the chassis 75 in the direction of arrow 76 (see FIG. 22A).

  A lever 79 is pivotally supported on the support shaft 78. A second gear portion 80 that can mesh with the first gear portion 74 of the turntable 101 is formed at one end of the lever 79 on the turntable 101 side. A recess 81 is formed at the other end of the lever 79. An eccentric cam 83 attached to the output shaft 82 of the second motor 72a is engaged with the recess 81.

  When the analysis device is continuously rotated by the first motor 71a, the support table 77 is pulled by the tension coil spring 88 interposed between the chassis 75 and the turntable 101 as shown in FIG. The support table 77 is retracted so that the second gear portion 80 does not mesh with the first gear portion 74.

  When reciprocating left and right at a predetermined amplitude range and cycle without continuously rotating the analysis device, when the third motor 73a attached to the chassis 75 is rotated, the output shaft of the third motor 73a The worm 85 attached to 84 is rotated, the worm wheel 86 is rotated, and a rack 87 formed on the support table 77 and meshing with the worm wheel 86 is driven, so that the support table 77 is shown in FIG. Advances, and the second gear portion 80 meshes with the first gear portion 74 of the turntable 101. Specifically, the third motor 73a is energized until the detection switch 91 detects the support table 77 as shown in FIG. 22B, and the worm wheel 86 is moved in the direction of arrow 89 (see FIG. 22A). When rotated, the support table 77 in which the rack 87 meshes with the worm wheel 86 slides so as to approach the turntable 101, and as shown in FIG. Meshes with the first gear portion 74 of the turntable 101.

  When the second motor 72a is further rotated in this state, the lever 79 swings in the tangential direction of the turntable 101 between the solid line position and the virtual line position shown in FIG. By increasing the rotation speed of the second motor 72a, an acceleration sufficient to stir a small amount of fluid in the analytical device set on the turntable 101 can be obtained in a short time.

  However, when the second gear portion 80 is engaged with the first gear portion 74 and the turntable 101 is reciprocated, the second gear is used when the analyzer is operated for a long period of time. The part 80 is worn, and the initial tooth shape indicated by the phantom line in FIG. 23 is deformed as indicated by the solid line.

  When the second gear portion 80 is worn in this manner, the frequency of the oscillation process for the purpose of stirring a small amount of fluid in the analysis device set on the turntable 101 fluctuates. There is a problem that the accuracy cannot be maintained.

  The present invention solves the above-described conventional problems, and is stable even when deformation such as wear of parts occurs when the turntable is engaged with a turntable on which an analysis device is set and the turntable is reciprocated. It is an object of the present invention to provide an analyzer equipped with a rotation drive device that can perform various swing processes.

  According to a first aspect of the present invention, there is provided an analyzing apparatus comprising: a first driving means for giving a rotational motion to a set analytical device; and a reciprocating motion to the analytical device selectively engaged with the first driving means. Analysis provided with a rotary drive device comprising: a second drive means for giving, and a third drive means for moving relative to a position where the first drive means and the second drive means are engaged and a position where they are not engaged A device that stores a rocking frequency of the second driving means corresponding to a set value, and reads a set value required to give a rocking of a target frequency to the analyzing device; A control device for executing a swing processing routine to be supplied to the second drive means, and the control device supplies the learning drive setting value to the second drive means to measure the swing frequency, The fluctuation of the oscillation frequency becomes small according to this measured value. Characterized by being configured to execute load fluctuation learning routine for updating the contents of the memory to the direction.

  The analyzer according to claim 2 of the present invention is the analyzer according to claim 1, wherein the control device cumulatively adds a count value corresponding to the content of the swing operation in the swing processing routine, and the cumulative added value is a threshold value. And a cumulative fluctuation value determination routine for resetting the cumulative addition value by instructing execution of the load fluctuation learning routine and detecting the load fluctuation learning routine.

  The analyzer according to claim 3 of the present invention is the analyzer according to claim 2, wherein the control device cumulatively adds a count value according to the content of the swing operation and a count value according to secular change in the swing processing routine. It is characterized by that.

  According to a fourth aspect of the present invention, there is provided the analyzer according to the first aspect, wherein the control device supplies a single set value for learning to the second driving means in the load fluctuation learning routine to provide the oscillation frequency. And the contents of the memory are updated in such a way that the fluctuation of the oscillation frequency becomes smaller in accordance with the measured value.

  The analyzer according to claim 5 of the present invention is the analyzer according to claim 1, wherein the control device supplies a plurality of set values for learning to the second driving means in a load fluctuation learning routine to each of the oscillation frequencies. And the contents of the memory are updated in a direction in which the fluctuation of the oscillation frequency becomes smaller by linearly approximating the two points of the actual measurement values.

  According to this configuration, even if a mechanical fluctuation accompanied by a load fluctuation occurs in at least one of the first driving means and the second driving means, the set value instructed by the control device to the second driving means is periodically set. Therefore, the fluctuation of the oscillation frequency of the analyzing device can be reduced, and the analysis accuracy can be maintained over a long period.

Below, the analyzer of this invention is demonstrated based on each embodiment of FIGS.
First, an analysis device used for analysis will be described with reference to FIGS. This analysis device is set on the turntable 101 of the rotary drive device 106 described with reference to FIG. 18 of the analysis apparatus, and the analysis device is set in the analysis apparatus as shown in FIGS.

  FIGS. 9A and 9B show a state in which the protective cap 2 of the analytical device 1 is closed and opened. FIG. 10 shows a state of disassembly with the lower side in FIG. 9A facing upward.

  This analytical device 1 shown in FIG. 9 and FIG. 10 includes a base substrate 3 having a microchannel structure having fine irregularities on the surface, a cover substrate 4 covering the surface of the base substrate 3, and a diluent. Are composed of four parts including a diluent container 5 that holds a protective cap 2 and a protective cap 2 for preventing sample liquid scattering.

The base substrate 3 and the cover substrate 4 are joined with the diluent container 5 and the like set therein, and the protective cap 2 is attached to the joined substrate.
By covering the openings of several concave portions formed on the upper surface of the base substrate 3 with the cover substrate 4, a plurality of storage areas and a flow channel of a microchannel structure that connects between the storage areas are formed. . 11 is a diluting liquid container housing part, 23 is a separation cavity, 25a, 25b and 25c are air holes, 28 and 30 are overflow channels, 29 is an overflow cavity, 31 is a reference measurement chamber, 33 is a capillary cavity, and 34 is The connecting channel, 36 is an overflow cavity, 37 is a capillary channel, 38 is a metering channel, 40 is a measurement chamber, and 41 is a connecting channel.

  When the sample liquid to be examined is blood, the gap between the flow paths of the microchannel structure on which the capillary force acts is set to 50 μm to 300 μm. The sample liquid attached to the spotting section 13 in the state of FIG. 9B is configured to be sucked up and taken in by the capillary force of the flow path formed between the base substrate 3 and the cover substrate 4. One side of the protective cap 2 is pivotally supported so that it can be opened and closed by engaging with shafts 6a and 6b formed on the base substrate 3 and the cover substrate 4. As shown in FIG. By closing, the diluent contained in the diluent container 5 is released from the diluent container 5 into the analysis device 1 as the diluent container 5 moves in the analysis device 1. Necessary ones in the storage area of the analysis device 1 are loaded with reagents necessary for various analyses.

The outline of the analysis step is to measure at least a part of the sample liquid taken in this way by diluting with the diluting liquid and then transferring it to the measuring chamber 40.
This analysis device 1 is set on the rotation drive device 106 of the analysis apparatus 100 shown in FIG. A groove 102 is formed on the upper surface of the turntable 101, and is formed on the rotation support portion 15 and the protective cap 2 formed on the cover substrate 4 of the analysis device 1 when the analysis device 1 is set on the turntable 101. The rotation support portion 16 thus engaged engages with and accommodates the groove 102.

  When the analysis device 1 is set on the turntable 101 and the door 103 of the analysis apparatus 100 is closed before the turntable 101 is rotated, the analysis device 1 is placed on the side of the door 103 set as shown in FIG. The position of the turntable 101 on the rotational axis 107 is pressed against the turntable 101 by the urging force of the spring 105, and the analysis device 1 is rotationally driven by the rotational drive device 106. Rotate integrally with the turntable 101.

  In the analysis process of the analyzer 100, the turntable 101 is rotated at a high speed by the first motor 71a as described above, the sample liquid is transferred toward the measurement chamber 40 of the analysis device 1, and the first step is performed during that period. In order to temporarily stop the driving of the motor 71a and swing the analyzing device 1, the third motor 73a is operated to bring the second gear portion 80 closer to the turntable 101, and The second motor 72a is operated.

Here, a case where a DC motor is used as the second motor 72a and the rotation speed changes according to the applied voltage will be described as an example.
After that, when the sample liquid obtained by diluting a specific component of the sample liquid with the diluting liquid arrives at the measurement chamber 40, the driving of the first motor 71a is temporarily stopped and the second motor 72a is operated to perform the analysis device. The reagent set in the measurement chamber 40 and the sample liquid are stirred to react with each other.

  Then, while rotating the turntable 101 again at a high speed by the first motor 71a, the detection light emitted from the light source 112 and passing through the solution in the measurement chamber 40 is read by the photodetector 113 as shown in FIG. Reading is done.

  If the swinging process is repeated, immediately after the start of use of the analyzer 100, the slidability of the members constituting the swinging mechanisms 81 and 83 and the surroundings is lubricated by grease. Since the load of the second motor 72a is drastically reduced as in the region a (load drastically decreasing region) shown in FIG. 2, the oscillation frequency of the analytical device 1 is maintained even when the voltage applied to the second motor 72a is the same. The content of the stirring process is not stable.

  In addition, even when the region a ends, the wear of the second gear portion 80 proceeds as in the region b (light load reducing region), and the engagement with the first gear portion 74 becomes gradually shallower, so that the second motor Due to the fact that the load of 72a gradually becomes lighter, as shown in FIG. 3, when the oscillation frequency at a certain time in the region b is compared with the characteristics at the final time in the region a, Δf (the oscillation frequency in FIG. The content of the stirring process is not stable even in the b region.

  In order to solve this problem, in the present invention, as shown in FIG. 1, the oscillation frequency of the first motor 71a during the oscillation process is detected by the oscillation frequency detection means 121, and this oscillation frequency detection means 121 detects the oscillation frequency. On the basis of the actually measured oscillation frequency read and the table written in the non-volatile memory 122, the microcomputer 123 as a control device reduces the second motor 72a via the oscillation motor driving means 124 so that the Δf is small. Control in the direction. In this embodiment, the first motor 71a is constituted by a brushless motor, and a hall sensor is mounted inside the first motor 71a for detecting the mechanical angle of the rotor. Voltage fluctuations occur in the detection output of the Hall sensor due to the reciprocating motion by stirring. Therefore, the oscillation frequency detecting means 121 detects the oscillation frequency from the fluctuation of the voltage of the detection output of the Hall sensor. Further, the microcomputer 123 controls the timing and direction of energization of the third motor 73a via the removable motor driving means 125 during the swinging operation.

  Immediately after manufacturing the analysis apparatus 100, the microcomputer 123 is set to the learning mode. In this learning mode, the microcomputer 123 reads the actual measurement value of the swing frequency detecting means 121 while changing the set value output to the swing motor driving means 124, and the microcomputer 123 stores the value in the area a shown in FIG. Write characteristics as a table.

  In this learning mode, it is ideal to learn the oscillation frequency by actually measuring the analysis device 1 set on the turntable 101. In this embodiment, however, the analysis device 1 is set on the turntable 101. It is assumed that learning is performed in a state where it is not.

When this learning is finished, the microcomputer 123 is switched to the analysis operation mode.
The microcomputer 123 set in the analysis operation mode executes the swing processing routine 400 of FIG. 4 in synchronization with the swing processing during the analysis process.

In step S1, the table of the set value-oscillation frequency relational expression written in the nonvolatile memory 122 is read.
In step S2, a setting value necessary for obtaining the target oscillation frequency during the analysis step is determined with reference to the table read in step S1, and this setting value is set in the oscillation motor driving means 124.

  In step S3, the third motor 73a is energized through the detachable motor driving means 125 to bring the second gear portion 80 closer to the turntable 101, and the swing driving motor driving means 124 is controlled to control the second gear section 80. A DC voltage having a voltage value corresponding to the set value is applied to the motor 72a, and the swing process of the analyzing device 1 is executed in step S4.

  In step S5, the microcomputer 123, which has detected that the specified time for the swing process has elapsed, ends the application of the DC voltage from the swing drive motor drive means 124 to the second motor 72a, and the detachable motor drive means. The third motor 73a is energized through 125 to separate the second gear portion 80 from the turntable 101, and the swing process for that time is completed.

  In step S6, a part or all of the addition value table 126 shown in FIG. 5 determined in advance by performing a wear experiment is referred to, and an appropriate value is applied to the register R based on the oscillation frequency of the oscillation processing at that time. Add additional values. Specifically, when the accumulated value of the register R is N1 by the previous swing process, and processing is performed with reference to the three rows on the addition value table 126, it is determined by the set value set in step S2. When the oscillation frequency at that time is 10 Hz to 20 Hz, the accumulated value (accumulated oscillation value) of the register R is incremented by 1 and updated to (N1 + 1) in the current step S6.

  In the case of processing with reference to the whole of the addition value table 126, the microcomputer 123 counts the elapsed time from the factory shipment of the analyzer, or the elapsed time from the difference between the date data and the factory date data. The time is calculated, the register R is updated with reference to the three rows on the addition value table 126 as described above, and an addition with a weight that increases as the elapsed time increases in accordance with the elapsed time Add the values. Specifically, when the elapsed time exceeds 3 years and reaches 4 years, it is configured to be +2. In this case, the cumulative fluctuation value is updated to (N1 + 1 + 2).

When step S6 of the swing processing routine 400 is completed, an accumulated swing value determination routine 600 shown in FIG. 6 is performed at an appropriate timing such as immediately after the end of the analysis process.
In step S7, the microcomputer 123 reads the accumulated fluctuation value from the register R. In step S8, it is checked whether the cumulative fluctuation value read in step S7 exceeds a preset threshold value.

When it is determined in step S8 that the cumulative fluctuation value does not exceed the threshold value, the cumulative fluctuation value determination routine 600 is terminated and the analysis process is returned to.
If it is determined in step S8 that the cumulative fluctuation value has exceeded the threshold value, the load fluctuation learning routine 700 in step S9 is executed. In this embodiment, the load variation learning routine 700 is performed in a state where the analysis device 1 is not set on the turntable 101.

FIG. 7 shows a load fluctuation learning routine 700 of the microcomputer 123.
In step S11, the load fluctuation learning routine 700 reads the table of the latest set value-oscillation frequency relational expression written in step S1 from the nonvolatile memory 122.

In step S12, a set value set in advance for learning is read. Here, it is assumed that the set value is 60.
In step S13, the third motor 73a is energized via the attach / detach motor driving means 125 to bring the second gear portion 80 closer to the turntable 101, and the set value 60 read in step S12 is driven by the swing motor. Set to means 124. Thus, the swing process is performed in step S14. During the swing, in step S15, the actually measured swing frequency output from the swing frequency detecting means 121 is read. If the actual reading value at this time is β shown in FIG. 8, in step S16,
β-α = Δf
In step S17, the table of the nonvolatile memory 122 is updated so that Δf approaches zero. Specifically, the set value is moved up and down by ΔV so that the current table (before update) of the nonvolatile memory 122 passes the point of the oscillation frequency β actually measured at the set value 60 in FIG. Rewrite to the one-dot chain line table (after update). At this time, the set value for learning used in the next step S12 is updated to 50, which is necessary for obtaining the oscillation frequency α in the updated table.

  When step S17 is completed, in step S10 shown in FIG. 6, the cumulative fluctuation value of the register R in which writing is performed in step S6 is reset to zero, and then the process returns to the analysis step.

  Thus, until the cumulative swing value exceeds the threshold value in step S8 in FIG. 6, every time the swing process is specified in the analysis process, the set value required for the swing operation at the specified swing frequency is set. Based on the latest table of the latest set value-oscillation frequency relational expression read from the non-volatile memory 122, the oscillation operation is performed in step S4, and the accumulated oscillation value is updated in step S6. Since the load fluctuation learning routine 700 shown in FIG. 7 is executed at an appropriate time according to the content of the dynamic operation to update the table of the nonvolatile memory 122, the second motor 72a in the a region and the b region is updated. Even if a load change occurs, the oscillation frequency in the oscillation process can be stabilized, and variations in the analysis process can be eliminated.

The point that the oscillation frequency in the oscillation process can be stabilized will be described in more detail.
Without executing the load fluctuation learning routine 700 shown in FIG. 7 described above, the analyzer is operated over a long period of time using the value set at the time of factory shipment as the setting value instructed to the swing motor driving means 124. In such a case, the swing motor driving means 124 continues to be instructed with the value set at the time of shipment from the factory as a set value despite the occurrence of deformation such as wear of parts. Even if the oscillation frequency is stabilized after the operation is started, the oscillation frequency at this time is higher than the required oscillation frequency by Δf because the deformation such as wear of parts has occurred as described above. While the feedback control is performed, the oscillation frequency reaches the target oscillation frequency, the response time from the start of oscillation to the required oscillation frequency increases, and the response time is disturbed. The contents of the process becomes unstable.

  In contrast, in this embodiment in which the cumulative fluctuation value determination routine 600 shown in FIG. 6 is executed to automatically execute the load fluctuation learning routine 700 shown in FIG. The value learned from the table in the direction in which Δf becomes smaller is adopted as the set value and instructed to the oscillating motor driving means 124, so that the value set at the time of shipment from the factory is set as the set value. Thus, the magnitude of Δf can be reduced, the response time when the oscillation frequency reaches the target oscillation frequency while performing feedback control can be shortened, and the content of the stirring process in the response time is stabilized.

  In the above embodiment, the swing process is performed in step S4 with reference to the set value-oscillation frequency relational expression table learned in a state where the analysis device 1 is not set on the turntable 101. When the oscillation frequency is measured while changing the set value with the analysis device 1 set on the turntable 101, the analysis device 1 is not set on the turntable 101 as shown by the characteristic P2 shown in FIG. Compared to the characteristic P1 in the case, both are substantially the same in the low-frequency oscillation region below 25 Hz. However, in the high-frequency oscillation range exceeding 25 Hz, the oscillation frequency in the state where the analysis device 1 is set on the turntable 101 is compared with the case where the analysis device 1 is not set even if the set value is the same. Therefore, the oscillation frequency tends to be low.

  Therefore, when the swing process extends to the high-frequency swing range, the characteristic P1 written in the non-volatile memory 122 is multiplied by a specific coefficient different for each swing frequency to calculate the characteristic P2. By rewriting the contents of the nonvolatile memory 122 and executing step S4, the analysis device 1 can be swung at an accurate swing frequency over a wide range from the low frequency swing range to the high frequency swing range.

  Alternatively, without performing the conversion process of the characteristic P1 to the characteristic P2, etc., the setting value is changed in a state where the analysis device 1 is set on the turntable 101 to learn the oscillation frequency, and the characteristic P2 is stored in the nonvolatile memory. It is also possible to write in 122 and execute step S4.

  In each of the above embodiments, the second driving means 72 is engaged with and driven by the first gear portion 74 provided on the turntable 101, but the outer rotor 90 of the first motor 71a is driven. A first gear portion 74 may be formed on the outer peripheral portion, and the second gear portion 80 of the second driving means 72 may be engaged therewith.

  In each of the above-described embodiments, the case where the second gear portion 80 of the rotation driving means 106 is gradually worn and the oscillation frequency fluctuates has been described as an example. However, the structure of the rotation driving means 106 is shown in FIG. As shown, the rotary drive device 106 configured to engage the turntable 101 and the lever 79 by bringing the friction member 202 also received at one end of the lever 79 into contact with the outer periphery of the turntable 101. In this case as well, there is a case where the oscillation frequency becomes unstable due to wear of the member 202 having friction as the operation progresses. In this case, the control can be similarly performed so as to reduce the Δf. . FIG. 15A shows a state in which the member 202 having friction is separated from the turntable 101, and FIG. 15B shows a state in which the member 202 having friction is in contact with the turntable 101.

  In the case of the rotation drive means 106 configured as shown in FIG. 14, the second drive means D2 is configured to reciprocate in the tangential direction of the turntable 101, and the drive source of the third drive means D3. Only the point that is a solenoid is different from the case of FIG. This difference will be described.

  As shown in FIGS. 14 and 15, the chassis 75 to which the first motor 71a is attached is provided with a second motor 72a, a solenoid 204, support shafts 203a and 203b, a support shaft 209, and the like.

  A lever 201 is slidably supported on the support shafts 203a and 203b by a spacer 210 and a fastening member 212. The side of the lever 201 on the turntable 101 side is bent and formed so as to be parallel to the rotor of the first motor 71a, and the rotor of the first motor 71a is formed at the tip of the bent side 201b. A friction member 202 made of cork, butyl rubber or the like that can be brought into frictional contact with is attached. The lever 201 has a recess 211 and is engaged with an eccentric cam 83 attached to the output shaft 82 of the second motor 72a.

  When the second motor 72a is energized in the state of FIG. 15B, the lever 201 reciprocates as shown by the arrow 213 in FIG. The third driving means D includes a solenoid 204 attached to the chassis 75, a lever 206 engaged with the solenoid 204, and an intermediate portion pivotally supported by a support shaft 209 implanted in the chassis 75, and one end of the lever 206. And a lever 205 that engages with a shaft 206b that is implanted. The other end 205b of the lever 205 is inserted into the hole 214 of the lever 201 and engaged with the tip of the bent side 201b.

  Further, the lever 205 biases the tip of the bent side 201b having the action of the leaf spring of the lever 201 in the direction of the arrow 215 in FIG.

  With this configuration, when the solenoid 204 is energized, the lever 206 is moved by the solenoid 204, and at the same time, the lever 205 rotates around the support shaft 209 as indicated by the arrow 216 in FIG. The leaf spring shape portion at the tip of the first member is restored, and the friction member 202 comes into contact with the rotor of the first motor 71a.

  When the second motor 72a is maintained in the energized state in this state, the turntable 101 is driven to swing by the lever 79 in the tangential direction of the turntable 101. Therefore, the rotational speed of the second motor 72a is increased. Thus, even in a short time, an acceleration sufficient to stir a minute amount of fluid in the analytical device 1 can be obtained in a short time.

  Although the lever 201 of the second driving means D2 is moved closer to the first motor 71a, the first motor 71a is moved closer to the lever 201 of the second driving means D2 and agitated. Alternatively, the first driving means D1 and the lever 201 of the second driving means D2 can be brought close to each other to agitate and shake the analysis device 1, and the third driving means D3 and the lever 201 are connected to the first driving means D3. It can be said that this can be realized by relatively moving the first driving means D1 and the second driving means D2 to a position where the motor 71a is engaged and a position where the motor 71a is not engaged.

  The friction member 202 is engaged with the first motor 71a. However, the friction member 202 of the lever 201 is changed to the second gear portion 80, and the turntable 101 or the first motor 71a is provided with the first friction member 202. Even if it is configured to engage with one gear portion 74, this can be realized.

  In the load fluctuation learning routine 700 of each of the above embodiments, the current table of the nonvolatile memory 122 indicated by the solid line in FIG. 8 is changed to a one-dot chain line table that is moved up and down by the set value ΔV. Although rewritten in step S17, more accurate control can be realized by updating the contents of the nonvolatile memory 122 to the result of learning at a plurality of points as shown in FIGS.

  Here, the current table of the nonvolatile memory 122 is the characteristic P1 shown in FIG. 8, and (x1, y1) (x2, y2) (x3, y3) (x4, y4) (x5, y5) is this characteristic. A plurality of points P1.

  In step S12-a in FIG. 16, the set values corresponding to a plurality (y1 to yn) of oscillation frequencies are stored in the table of the latest set value-oscillation frequency relational expressions read from the nonvolatile memory 122 in step S11. Determine based on. Here, a plurality of points will be described as five points y1 to y5. In this case, for example, set values y1 = 40, y2 = 60, y3 = 80, y4 = 100, and y5 = 120 shown in FIG. 17 are set.

  In step S13-a, the third motor 73a is energized through the attach / detach motor driving means 125 to bring the second gear portion 80 closer to the turntable 101, and the swing motor driving means 124 is instructed to operate.

In step S13b, the contents of a specific register in the microcomputer 123 storing the measurement completion point from the start of learning are set to yn = y1.
In step S14, based on y1 of the contents of the specific register, the set value 40 is set in the swing motor driving means 124 and the swing process is executed.

In step S15, the actually measured oscillation frequency xn = x11 of the oscillation frequency detecting means 121 at this time is read.
In step S16-a, x11 read in step S15 is stored in the RAM in the microcomputer 123 in association with the set value y1.

  In step S16-b, it is determined whether or not the number of actually measured points that have been learned has reached a prescribed value of five. If yn ≠ y5, the contents of the specific register are updated to yn + 1 in step S16-c, and the process returns to step S14. As a result, in the next step S14, the set value 60 is set in the swing motor driving means 124 and the swing process is executed. In step S15, the actually measured oscillation frequency xn = x21 of the oscillation frequency detecting means 121 is read. In step S16-a, x21 read in step S15 is stored in the RAM in the microcomputer 123 in association with the set value y2.

  The routine from step S16-c to step S16-a is repeated until yn = y5 is detected in step S16-b, and (x11, y1) (x21, y2) (x31, y3) (x41, y4) (x51, Learn y5).

  In step S16-d, the linear 1 between (x11, y1) (x21, y2) is linearly approximated, the linear 2 between (x21, y2) (x31, y3) is linearly approximated, and (x31, y3 ) Linearly approximate line 3 between (x41, y4), linearly approximate line 4 between (x41, y4) (x51, y5), linear 1, linear 2, linear 3, linear 4, The contents of the nonvolatile memory 122 are updated to a table in which (x11, y1) is linear 1 and (x51, y5) is linear 4. FIG. 18 shows a specific example in which linear 1 to linear 4 are calculated.

  In each of the above-described embodiments, the nonvolatile memory 122 is configured to be updated when the analysis device 1 is not set at the time of factory shipment and subsequent learning. The nonvolatile memory 122 can be updated to an optimum value during the standby time until the device 1 is set. As described above, the nonvolatile memory 122 can be configured to be updated while the analysis device 1 is set at the time of factory shipment and subsequent learning.

  The present invention contributes to the improvement of analysis efficiency by stably maintaining the analysis accuracy of an analyzer used for component analysis of a liquid collected from a living organism or the like over a long period of time.

Configuration diagram of the control system of the rotary drive device in the analyzer of the present invention Relationship diagram between the number of cumulative swing processes and the change in mechanical load of the same rotation drive unit Relationship diagram between set value and swing frequency for swing motor drive means of the same rotation drive unit Flow chart of swing processing routine of the same embodiment Explanatory drawing of the addition value table of the embodiment Flow chart of cumulative fluctuation value determination routine of the same embodiment Flow diagram of load variation learning routine of the embodiment Explanatory drawing of the update in the load fluctuation learning routine of the same embodiment External perspective view of the analytical device with the protective cap closed and open Exploded perspective view of the analysis device of the same embodiment The perspective view of the state which opened the door of the analyzer of the embodiment Cross-sectional view of the relevant part with the analysis device set in the analyzer Relationship between set value and oscillation frequency when analysis device is set and not set The perspective view of the rotation drive device of another embodiment The top view of the state which the engagement of the 1st drive means and the 2nd drive means of the rotational drive device was cancelled | released, and the top view of the state which the 1st drive means and the 2nd drive means engaged Load variation learning routine when learning by actually measuring the oscillation frequency at multiple points Explanatory drawing of FIG. Explanatory drawing of a specific calculation example of FIG. Partially cutaway perspective view of analysis device of Patent Document 1 Partially cutaway perspective view of Patent Document 2 Perspective view of rotation drive device 21 is a plan view of a state where the engagement between the first drive means and the second drive means is released, and a plan view where the first drive means and the second drive means are engaged. Figure Enlarged view of the second gear

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Analyzing device D1 1st drive means D2 2nd drive means D3 3rd drive means 71a 1st motor 72a 2nd motor 73a 3rd motor 74 1st gear part 79 Lever 80 2nd gear Part 80
83 Eccentric cam 85 Worm 86 Worm wheel 87 Rack 101 Turntable 106 Rotation drive device 121 Oscillation frequency detection means 122 Non-volatile memory (memory)
123 Microcomputer (control device)
124 swing motor drive means 125 detachable motor drive means 400 swing processing routine 600 cumulative swing value determination routine 700 load fluctuation learning routine

Claims (5)

First driving means for imparting rotational motion to the set analytical device; second driving means for selectively engaging the first driving means to provide reciprocating motion to the analytical device; An analyzer comprising a rotary drive device comprising a drive means and a third drive means for relative movement to a position where the drive means and the second drive means are engaged and a position where the drive means is not engaged,
A memory storing the oscillation frequency of the second driving means corresponding to a set value;
A control device that executes a swing processing routine that reads a set value necessary to give a swing of a target frequency to the analyzing device and supplies the set value to the second drive means; and A load fluctuation learning routine for supplying a set value for learning to the second driving means to actually measure the fluctuation frequency, and updating the contents of the memory in a direction in which fluctuation of the fluctuation frequency is reduced in accordance with the actual measurement value. An analyzer configured to perform The control device cumulatively adds a count value corresponding to the content of the swing operation in the swing processing routine, detects that the cumulative added value has exceeded a threshold value, and instructs the load variation learning routine to execute it. The analysis apparatus according to claim 1, wherein a cumulative fluctuation value determination routine for resetting the cumulative addition value is executed. The analyzer according to claim 2, wherein the control device cumulatively adds a count value corresponding to the content of the swing operation and a count value corresponding to a secular change in the swing processing routine. In the load fluctuation learning routine, the control device supplies a single set value for learning to the second driving means to measure the fluctuation frequency, and fluctuation of the fluctuation frequency is small according to the actually measured value. The analysis apparatus according to claim 1, wherein the contents of the memory are updated in the following direction. In the load fluctuation learning routine, the control device supplies a plurality of set values for learning to the second driving means to measure each oscillation frequency, and linearly approximates the two points of the actually measured values to perform oscillation. The analyzer according to claim 1, wherein the contents of the memory are updated in a direction in which fluctuations in dynamic frequency are reduced.

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