JP5178891B2 - Automatic analyzer - Google Patents

Description

  The present invention relates to an automatic analyzer that automatically performs qualitative / quantitative analysis of biological components such as blood and urine, and more particularly to an automatic analyzer that can be loaded with more reagents and has high throughput per hour.

  In the field of automatic analysis, a random access type automatic analyzer that uses a plurality of reaction lines at random has been developed, and the processing capacity of analysis has been dramatically improved. As a result, the speed of reagent consumption has increased, and the opportunity for reagent switching has increased. A method in which a plurality of reagent containers are placed on a rotating disk called a reagent disk, and the target reagent is dispensed from the target reagent container using a reagent dispensing probe by rotating the reagent disk. It is. In this case, set a plurality of reagent containers of frequently used reagent types on the reagent disk so that when the reagent in one reagent container is insufficient, the reagent can be separated from the other reagent container. An automatic analyzer that prevents the middle stage of analysis due to shortage is described in Patent Document 1. In addition, when replacing the reagent, information indicating an effective period after the start of use of the reagent is set, and an automatic analyzer that issues a warning when the elapsed time after the start of use of the reagent exceeds the effective period Is described in Patent Document 2.

Utility Model Registration Gazette No. 2503751 JP 2000-310443 A

  In the conventional technique, an operator must perform various operations such as setting of a reagent before analysis, checking of a remaining amount, and registration of a reagent when the reagent is not barcode-managed. In addition, if a reagent is set in the reagent storage by reagent barcode management, the operator interrupts the analysis if the reagent runs out during the analysis even if the system manages the reagent later. Then, new reagent bottles must be prepared and set in the reagent storage, and if necessary, reagent registration must be performed. In addition, in the case of a system that has multiple reagent storages to increase the amount of reagents that can be loaded, or a system in which the analysis processing capacity changes depending on the placement of reagents in the reagent storages, the operator must also manage the placement of reagents. There is a problem of not becoming.

  An object of the present invention is to provide an automatic analyzer that reduces the burden on an operator due to operations such as reagent registration and reagent replacement, and minimizes interruption of analysis without causing a shortage of reagents during analysis.

  The configuration of the present invention for achieving the above object is as follows.

  A first reagent container storage unit that can store a plurality of reagent containers, a reagent sorting mechanism that separates reagents from the reagent containers stored in the first reagent container storage unit, and a plurality of reagent containers can be stored A second reagent container storage unit and a reagent container transfer mechanism capable of transferring a reagent container selected from the reagent containers stored in the second reagent container storage unit to the first reagent container storage unit The reagent container transfer mechanism moves the reagent container from the second reagent container storage unit to the first reagent container storage unit based on a predetermined priority order. Automatic analyzer with a mechanism to transport.

  In the predetermined reagent movement priority order, the difference between the reagent amount necessary for starting the analysis stored in advance and the remaining reagent number in the reagent storage means may be sequentially determined.

  Moreover, you may provide the function in which a priority is registered by an operator. In this case, there is preferably a display device that can display a registration screen.

  As described above, according to the present invention, in addition to the reagent storage means for analysis, the reagent storage means for replenishment and the reagent bottle transport means are provided, thereby reducing the burden on the operator due to reagent management and registering the reagent. , It is possible to provide an automatic analyzer that minimizes interruption of analysis due to replacement, is loaded with many reagents, and has a high throughput per hour.

The top view of the analyzer of an example. Reagent input priority of the example. The reagent injection | flow_flow diagram of an Example. The figure which shows the example of calculation of reagent residual amount.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a top view of a first embodiment of the present invention. The reaction vessels 35 are arranged on the circumference of the reaction disk 36 on the housing 62. A reagent disk 42 is disposed inside the reaction disk 36 and a reagent disk 41 is disposed outside. A plurality of reagent containers 40 can be placed on the circumference of each of the reagent disks 41 and 42. Two reagents enter one reagent container 40. A transport mechanism 12 for moving the rack 11 on which the sample container 10 is placed is installed near the reaction disk 36. Rails 25 and 26 are arranged on the reagent disk 41 and the reagent disk 42. The rail 25 includes reagent probes 20 and 21 movable in a direction parallel to the rail and in the vertical direction. Removable reagent probes 22 and 23 are installed. The reagent probes 20, 21, 22, and 23 are connected to reagent pumps not shown in the figure. Between the reaction vessel 35 and the transport mechanism 12, sample probes 15 and 16 that can be rotated and moved up and down are installed. Each of the sample probes 15 and 16 is connected to a sample pump not explicitly shown in the figure. Around 36, stirring devices 30 and 31, a light source 50, a detection optical device 51, and a container cleaning mechanism 45 are arranged. The container cleaning mechanism 45 is connected to a cleaning pump not explicitly shown in the figure. A cleaning port 54 is installed in each operation range of the sample probes 15 and 16, the reagent probes 20, 21, 22 and 23, and the stirring devices 30 and 31. A replenishing reagent storage 71 is installed on the reagent disk 41. A plurality of reagent containers 40 can be mounted in the replenishment reagent storage 71. A rail 72 is disposed on the reagent storage 71 for replenishment. The rail 72 is provided with a reagent holding mechanism 73 and a reagent cap opening mechanism 74 that are movable in three axial directions. A reagent container 40 erection port 75 is installed in front of the replenishment reagent storage 71. In the vicinity of the reagent container 40 installation port 75, a barcode reader 76 is installed to read the reagent barcode. In the vicinity of the replenishing reagent storage 71, a disposal port 77 for discarding the reagent cap and the used reagent container 40 is provided. Sample pump, reagent pump, washing pump, detection optical device 51, reaction vessel 35, reagent disk 41, reagent probe 20, 21, 22, 23, sample probe 15, 16 and reagent holding not shown in the figure The mechanism 73, the reagent cap opening mechanism 74, and the reagent container installation port 75 are connected to the controller 60, respectively.

  An analysis procedure using this apparatus will be described.

  Before starting the analysis, the equipment is first maintained. For maintenance, in addition to inspection of the detection optical device 51, cleaning of the reaction container 35, cleaning of various probes such as the sample probes 15 and 16, and the like, the most important thing is the inside of the reagent container 40 mounted on the reagent disks 41 and 42. This is a reagent check. Information on the reagent container 40 is stored in a control computer in which reagent mounting positions, lots, expiration dates, reagent remaining amounts, etc. in the reagent disks 41 and 42 are not clearly shown in the figure. The operator checks the state of the reagent container 40 in the reagent disks 41 and 42 by a CRT or the like not explicitly shown in the figure. A reagent that has a small remaining amount of reagent and is likely to be lost during one day of analysis is set in the reagent container 40 installation port 75. The reagent information of the set reagent is read by the barcode reader 76 and conveyed to the replenishment reagent storage 71 by the reagent holding mechanism 73. The read reagent information and the loading position loaded in the replenishment reagent storage 71 are output to a control computer not shown in the figure.

  Next, a method of transporting the reagent from the replenishing reagent storage 71 to the reagent disks 41 and 42 is shown in FIGS. A plurality of reagents can be loaded in the replenishment reagent storage 71. The apparatus stores in advance a reagent and reagent amount necessary for starting analysis stored in the apparatus in advance, and a reagent and reagent amount essential for starting analysis stored in a control computer not explicitly shown in the figure. The means for storing may be input by an operator from a control computer not explicitly specified, or may be stored by an external storage medium. Further, the reagent and the reagent amount stored by the determination of the apparatus can be automatically changed according to the frequency of use of the apparatus. The apparatus inputs the reagent in accordance with the priority order shown in FIG. 2, for example, with respect to the reagent and reagent amount stored in advance in the apparatus. FIG. 4 shows an example relating to calculation of the priority order of reagents essential for starting analysis. In FIG. 4, first, the operator gives an input instruction (109). The apparatus calculates the difference between the reagent amount necessary for starting the analysis stored in advance and the reagent amount in the reagent disks 41 and 42 (110, 111). FIG. 3 shows a flow chart of input. The apparatus calculates the priority order of the reagents to be charged for the reagents in the replenishment reagent storage 71 after being instructed to input the reagents (102). Subsequently, the presence / absence of an empty position in the reagent disks 41 and 42 is confirmed (103). If there is no empty position, the reagent stays in the replenishing reagent storage 71 until the condition of 108 occurs (107). On the other hand, if there is an empty reagent arrangement position in the reagent disks 41 and 42 due to the condition 103, the apparatus transports the reagent from the replenishing reagent storage 71 to the reagent disk 41 or 42 by the reagent holding mechanism 73. (104). If there are more reagents to be transferred to the reagent disk in the replenishment reagent storage 71 even after the transfer is completed (105), the flow after 103 is repeated. If there is no reagent in the replenishment reagent storage 71, the operation is terminated (106).

  A sample to be inspected, such as blood, is placed in the sample container 10, placed on a rack 11, and carried by a transport mechanism 12. A sample collected by the sample probe 15 is dispensed into a reaction container 35 arranged in a certain amount on the reaction disk 36, and a certain amount of reagent is supplied from the reagent container 40 installed on the reagent disk 41 or 42 to the reagent probe 21 or After being dispensed from No. 22, stirred by the stirring devices 30 and 31, reacted for a predetermined time, measured by the detection optical device 51, and output as a measurement result to a control computer not explicitly shown in the figure. If more measurement items are requested, the above sampling is repeated. Similarly, the process is repeated for all the samples on the rack 11 until sampling of the set measurement items is completed.

  DESCRIPTION OF SYMBOLS 10 ... Sample container, 11 ... Rack, 12 ... Conveyance mechanism, 14 ... Sample pump, 15, 16 ... Sample probe, 20, 21, 22, 23 ... Reagent probe, 24 ... Reagent pump, 25, 26, 72 ... Rail, 30, 31 ... Stirrer, 35 ... Reaction vessel, 36 ... Reaction disc, 40 ... Reagent vessel, 41, 42 ... Reagent disc, 45 ... Container cleaning mechanism, 46 ... Cleaning pump, 50 ... Light source, 51 ... Detection Optical device 54 ... Washing port 60 ... Controller 62 ... Housing 71 ... Replenishing reagent storage 73 ... Reagent holding mechanism 74 ... Reagent cap opening mechanism 75 ... Reagent container installation port 76 ... Bar code Reader, 77 ... Disposal port, 78 ... Reagent loading port.

Claims (3)

A first reagent container storage unit capable of storing a plurality of reagent containers;
A reagent dispensing mechanism for dispensing a reagent from a reagent container stored in the first reagent container storage;
A second reagent container storage unit capable of storing a plurality of reagent containers;
A reagent container transfer mechanism capable of transferring a reagent container selected from among the reagent containers stored in the second reagent container storage unit to the first reagent container storage unit;
An automatic analyzer equipped with
When the reagent container transfer mechanism transfers a reagent container from the second reagent container storage unit to the first reagent container storage unit, control is performed so that a reagent having an effective calibration curve result is transferred with priority. Control means to
The control means, when there are a plurality of reagents already having an effective calibration curve result, selects a reagent to be preferentially transferred based on the expiration date of those reagents. The automatic analyzer according to claim 1, wherein
An empty position check mechanism for checking whether there is an empty position in which the reagent container of the first reagent container storage unit is not placed;
The reagent container of the reagent transferred with priority to the empty position detected by the empty position check mechanism is transferred using the reagent container transfer mechanism, and further, the next empty position detected by the empty position check mechanism. The reagent container of the reagent that is transported next is transported using the reagent container transport mechanism, and the reagent container is placed on the first reagent container storage unit. The automatic analyzer according to claim 2,
When the empty position check mechanism detects that there is no empty position in the first reagent container storage unit,
Causing the second reagent container storage unit to wait for the reagent container having the highest priority,
As soon as the empty position check mechanism detects that an empty position has occurred in the first reagent container storage unit, the reagent container having the highest priority is transferred to the first container using the reagent container transfer mechanism. An automatic analyzer characterized by being transferred to a reagent container storage unit.

Images