JP5156998B2 - Drug gel and drug diffusion method using the same - Google Patents

Description

  The present invention provides a drug gel used by stirring in water and a method for diffusing the drug into the air using the drug gel.

  As a method of diffusing oily chemicals such as fragrance and deodorant components in the air, fill the tank of a chemical diffusion device such as an atomizer or electric fragrance diffuser, add fragrance or essential oil to the water, and stir By making it, the method of diffusing an aromatic component in the air is known (for example, patent documents 1-3). As a method for adding chemicals to these apparatuses, a method in which a fragrance or an essential oil is directly added to water as it is.

  On the other hand, it is known that a hydrogel is used as a base material for volatilizing a fragrance component and a deodorant component (for example, Patent Documents 4 and 5). These hydrogels are prepared using a surfactant in order to obtain the stability of the preparation and the sustained release of the drug, and the drug is incorporated into the gel.

Japanese Patent Publication No. 32-4393 Japanese Utility Model Publication No. 45-7757 JP 2004-147799 A JP 2007-119556 A JP 2007-291145 A

  However, the conventional drug diffusion method in which fragrances, essential oils, and the like are directly added to the water in the tank in the drug diffusion apparatus and stirred is difficult to see how the water in the tank is moving, and is not interesting to the eye. In order to increase the diffusibility of the drug, it is necessary to increase the stirring power of water. To increase the stirring power, increasing the motor and fan and increasing the rotational speed increase the power consumption and operating noise. There was a problem of becoming. It would be desirable to provide a method for diffusing a drug that is easier and more visually appealing and that is more visually appealing and beautiful.

  As a result of various studies, the present inventors have obtained a drug gel in which an oily drug such as a fragrance or an essential oil is retained on the surface of a granular gel swollen with water without using a surfactant, and this is added to water. It has been found that the above-mentioned problems can be solved by stirring water and gel and diffusing an oily drug in the air. That is, the present invention relates to the following configurations (1) to (4).

(1) A granular gel swollen with water in which at least an oily drug is held on the surface, substantially free from a surfactant, and stirred in water.
(2) The drug gel according to claim 1, wherein the granular gel is a water-absorbing polymer swollen with water.

(3) The drug gel according to claim 1 or 2, further comprising a polyhydric alcohol.
(4) A drug diffusion method, wherein the drug gel according to any one of (1) to (3) is added to water, and the oil and drug are diffused in the air by stirring the water and the gel.

  In the present invention, since the oily drug such as a fragrance component or deodorant component is held on at least the surface of the granular gel swollen with water, the oily drug on the surface is quickly released into the water when added to water. . Addition of multiple drug gels in water and stirring together with the gel increases the diffusibility of the drug in water and allows the drug components to diffuse efficiently compared to adding the drug directly to water. . In addition, since the behavior of the gel is visible, the operation of the apparatus can be confirmed, and the appearance is also beautiful and enjoyable.

  The drug gel of the present invention is different from a conventionally known hydrous gel containing an oily drug in that it is used in a completely different manner and does not substantially contain a surfactant. Conventional water-containing gels are not used by being added to water, but are prepared using a surfactant in order to obtain the stability of the preparation and the sustained release of the drug, and the drug is taken into the gel. Therefore, even when a gel containing a conventional surfactant is added to water and stirred, the drug inside the gel is not released into the water, and since the surfactant is present, the drug is emulsified and solubilized in water. Therefore, the effect of quick diffusion into the air cannot be expected. Moreover, since the surfactant is eluted in water, foaming occurs during stirring, which is not preferable in appearance.

  In the present invention, the fact that it does not substantially contain a surfactant does not exclude even a compound having a surface active action until it is added for the purpose of imparting other effects. This means that the compound may be contained within a range that does not inhibit the above effect of the present invention.

1 shows a schematic perspective view of a drug diffusion device that can be used to diffuse the drug gel of the present invention into the air.

  In the drug gel of the present invention, the oily drug is retained on at least the surface of the granular gel swollen with water, and the surfactant gel does not substantially contain a surfactant. The drug is quickly released into water. For example, the drug gel of the present invention is added to the water in the tank of the drug diffusion device shown in FIG. be able to.

  The oily drug of the present invention is not particularly limited as long as it can express a desired function when the drug gel of the present invention is stirred in water and diffused in the air. It is appropriately selected according to the application. For example, an aromatic component, a deodorant component, an insecticide / insecticide component, an antibacterial component, etc. are mentioned.

  Examples of the oily agent include fragrance ingredients, for example, animal fragrances such as musk fragrance, ghost cat fragrance, and Ryunobu fragrance, Abies oil, Akjon oil, almond oil, Angelica root oil, pagele oil, bergamot oil, perch oil, boad rose oil , Kayabuchi oil, Gananga oil, Capsicum oil, Caraway oil, Cardamom oil, Cassia oil, Celery oil, Cinnamon oil, Citronella oil, Cognac oil, Coriander oil, Cumin oil, Camphor oil, Jill oil, Estgolan oil, Eucalyptus oil, Examples of plant flavors such as fennel oil, garlic oil, ginger oil, grapefruit oil, hop oil, lemon oil, lemongrass oil, nutmeg oil, mandarin oil, mint oil, orange oil, sage oil, star anise oil, turpentine oil be able to. Artificial fragrances such as synthetic fragrances or extracted fragrances can also be used as these fragrances. For example, hydrocarbon fragrances such as pinene and limonene, linalool, geraniol, citronellol, menthol, borneol, benzyl alcohol, anis alcohol, β-phenethyl Alcohol-based fragrances such as alcohol, phenol-based fragrances such as anethole and eugenol, aldehyde-based fragrances such as n-butyraldehyde, isobutyraldehyde, hexyl aldehyde, citral, citronellal, benzaldehyde, cinnamic aldehyde, carvone, menthone, camphor, acetophenone, Ketone flavors such as ionone, lactone flavors such as γ-butyl lactone, coumarin, cineol, octyl acetate, benzyl acetate, cinnamyl acetate, propionic acid Examples include ester-based fragrances such as butyl and methyl benzoate.

  Other oily agents include, for example, plant extracts such as ethylhexyl glyceryl, flavonoid compounds, catechins, polyphenols or derivatives thereof, deodorant components such as cyclodextrins or derivatives thereof, empentrin, transfluthrin, allethrin, phenothrin, methofurrine, Examples include insecticide / insecticidal components such as pyrethroid compounds such as profluthrin, and antibacterial components such as isopropylmethylphenol.

  These oily drugs may be used alone or in combination of two or more. As the oily agent of the present invention, an aromatic component and a deodorizing component are preferable.

  In the present invention, the “granular gel swollen with water” is not particularly limited as long as it forms a granular gel by swelling with water. For example, gelatin, collagen, carrageenan, pectin, gellan gum, agar, xanthan gum A granular gel can be obtained by swelling a natural gelling agent such as alginic acid and a synthetic gelling agent such as a water-absorbing polymer with water.

  Examples of the water-absorbing polymer that can be used in the present invention include a polymerizable monomer that becomes water-soluble or water-soluble by hydrolysis, for example, polysaccharides such as starch and cellulose, such as acrylic acid, methacrylic acid, and acrylic. Acid salt, methacrylic acid salt, acrylic acid ester, methacrylic acid ester, acrylic acid amide, methacrylic acid amide, acrylonitrile, methacrylonitrile, maleic acid, sulfonated styrene, polyvinyl pyridine, etc., or oligomers or co-oligomers thereof Graft-polymerized hydrophilic polymer and hydrophilic polymer hydrolyzed if necessary after kraft polymerization, or polyethylene oxide, polypropylene oxide, polyvinyl pyrrolidone, sulfonated polystyrene, polyvinyl pyridine, polyacrylamide, poly Methacrylic acid salts, such as a hydrophilic polymer such as polyacrylic acid amide that three-dimensionally polymerized by cross-linking agent is used. Methods for producing these water-absorbing polymers are well known.

  These gelling agents can appropriately set the material, shape, and other characteristics in consideration of the shape and size of the target granular gel.

The drug gel of the present invention can be prepared by causing water (or an aqueous solution when an additive component is present) to be absorbed and swollen by the gelling agent. The oily drug may be contained in the water (aqueous solution) to be swollen and held in the gel together with the water (aqueous solution), or a solution containing the oily drug may be contained in the gel swollen with water (aqueous solution). Further, it may be absorbed and held on at least the surface of the gel.
When glycerin or the like is used, it cannot be further absorbed in the gel swollen with water, and therefore, it is necessary to swell the gel prepared as an aqueous solution by absorbing it as described above.

  The granular drug gel can be used by appropriately adjusting its size according to the size of the drug diffusing device, the diffusion method, etc., but the particle size is preferably about 5 to 20 mm. By this, when stirring with water, the stirring property of water is enhanced, the diffusibility of the oily drug is improved, the gel moves in the water, and the appearance is beautiful and enjoyable.

  Since the granular drug gel produced as described above is held on at least the surface of the granular gel in which the oily drug is swollen with water, the oily drug is easily released into the water by adding it to the water and stirring with the gel. And disperse. Furthermore, since the drug gel of the present invention does not substantially contain a surfactant, the oily drug released in water can be efficiently and quickly diffused into the air without being solubilized or emulsified in water. Can continue.

  In the present invention, when an aqueous gelling agent is swollen with water to prepare a granular gel, it is preferable to contain a polyhydric alcohol in the aqueous solution to be swollen. While preparing a drug gel, it functions as a solubilizing aid that assists in dissolving the drug in an aqueous solution, and effectively prevents water separation and freezing of the obtained drug gel. The polyhydric alcohol that can be used is not particularly limited as long as it can exhibit the above functions, and examples thereof include glycerin, propylene glycol, and butylene glycol.

  The content of the oily drug and polyhydric alcohol in the drug gel of the present invention may be used within the range in which the above effects are obtained, and is not limited, but is 0.1 to 5% by mass of the oily drug, and more preferably 1 to 1%. It is preferable that they are 2 mass%, polyhydric alcohol 1-50 mass%, and also about 5-10 mass%.

Furthermore, the drug gel of the present invention is, in addition to the above-described blending components, as long as it does not interfere with the effects of the present invention, if necessary, preservatives, antioxidants, ultraviolet absorbers, pigments, dyes, accidental ingestion prevention An appropriate amount of a component such as an agent can also be contained.
These other components can be easily contained and held in the drug gel by being contained in the aqueous solution used when the aqueous gelling agent is swollen, and can be appropriately set as necessary.

  The shape of the drug gel of the present invention is not particularly limited, and may be, for example, a spherical shape, a rectangular shape, a star shape, or a special shape such as an animal, a plant, or an anime character. .

  The device used for diffusing an oily drug into the air using the drug gel of the present invention is not particularly limited, and is conventionally known as an atomizer, an electric device that can diffuse a drug component in water in the air. Devices such as fragrance diffusers, humidifiers and air purifiers can be used. By putting the drug gel of the present invention together with water into tanks installed in these apparatuses and stirring the water and drug gel according to the specifications of the apparatus, the oily drug held in the drug gel of the present invention is According to the specifications of the drug diffusion device used, the oily drug is stirred together with water and efficiently diffused into the air.

When diffusing a drug into the air using the drug gel of the present invention, for example, a drug diffusing device shown as a schematic perspective view in FIG. 1 can be used. A drug diffusing device 1 shown in FIG. 1 includes a tapered water absorption pipe 3 provided with a water inlet 5 and an outlet 6, a fin 4 provided on the upper part thereof, and an electric motor for rotating the water absorption pipe and the fin (FIG. 1). (Not shown) is provided in such a form that covers the opening of the tank 2 for storing water, and the protective cover 7 is further provided with an air inlet 8 and an air outlet 9. Is provided.
In this drug diffusing device 1, by the rotation of the fins 4, the water that has entered from the water intake port 5 at the tip of the water absorption tube 3 moves up the tapered water absorption tube by centrifugal force and is ejected from the upper jet port 6. A water curtain is formed in the tank 2, and the air in the tank 2 is brought into contact with the water curtain, so that the air contains an oily chemical component and the air is discharged from the air discharge port 9.

The tank 2 stores water, and has an opening at the upper end. The fin 4 and the water absorption pipe 3 connected to the electric motor (not shown, inside the protective cover 7) are connected to the opening. It is set so that it is inserted and a lid is formed by the protective cover 7. The fin 4 and the water absorption pipe 3 are rotated by energization. A plurality of spouts 6 are formed above the water suction pipe 3 (near the connecting portion with the fins 4). When the fins 4 are rotated, air is once sucked into the tank 2 from the air suction port 8, and at this time Water stored in the tank is sucked into the water suction pipe 3 from the water suction port 5, rises in the tapered water suction pipe by the centrifugal force, and is ejected from the jet outlet 6. Since the spout 6 is rotating, a water curtain is formed in the tank 2, and the water curtain can clean the air in the tank 2, and can further contain an oily chemical in the air.
On the inner surface of the water absorption pipe 3, one or a plurality of flow guides are formed so as to rise along the axial length direction (not shown), and the current guide is used as a stirring member for water in the water absorption pipe. It is functioning. By stirring efficiently by this, the water in a water absorption pipe can be raised along a taper by centrifugal force.

  In order to apply the drug gel of the present invention to the drug diffusion device, the protective cover is once removed, water is put into the tank up to a predetermined height (at least until the water inlet 5 at the tip of the water absorption pipe is immersed), and the water is added to the water. Add the appropriate amount of the inventive drug gel. After that, when the protective cover 7 provided with the water absorption pipe 3, the fin 4 and the electric motor is attached to the opening of the tank 2 and covered, the electric motor is operated and the fin 4 and the water absorption pipe 3 are rotated. As described above, the air containing the oily chemical is discharged from the air discharge port 9 of the apparatus.

  The drug gel of the present invention can be devised by appropriately setting the color and shape, and in this case, the tank portion for storing water as shown in FIG. 1 is made transparent so that it can be seen from the outside. It is preferable to make it.

  The amount of the drug gel of the present invention added to water is not particularly limited, and the performance of the apparatus used, its application location (indoors, outdoors, etc.), the nature of the oily drug used (degree of volatility, uses such as aroma and odor prevention, etc. ), Content is set as appropriate. For example, in the case of an indoor diffusion device, it is preferable to apply about 4 to 20 g of drug gel to 100 to 500 mL of water in order to obtain an effective stirring effect in water. The drug gel of the present invention also has an advantage that it can be easily quantified as compared with a method of directly adding a drug to water.

  Hereinafter, the present invention will be described in more detail with reference to examples. The present invention is not limited to the following examples.

Example 1
The Example which manufactured the spherical chemical | medical agent gel (fragrance bead) using the fragrance component as an oil-based chemical | medical agent is illustrated.

(1) Preparation of aroma beads By using an acrylamide-acrylate copolymer (particle size: about 1.5 to 2 mm) as a water-absorbing polymer, by absorbing water containing an aromatic liquid containing the following components, A drug gel according to the following prescription was obtained. The particle size of the drug gel after swelling was about 7 mm.

(2) Fragrance diffusion Two apparatuses shown in FIG. 1 were prepared, 200 mL of water was poured into the tank portion, and 8 g of the aroma beads prepared in the above formula 1 or formula 2 were added thereto. These were placed in chambers (non-ventilated conditions) having a volume of about 2000 L (0.8 × 1.3 × 1.9 m), respectively, and energization was started at the same time. The water in the tank was rotated at a rotational speed of about 1350 rpm and an air volume of about 0.00. Stirring was performed at 5 L / sec.
Five minutes after the start of energization, the intensity of the scent in the chamber was evaluated by a monitor test (13 persons).
The test was repeated twice, and a chamber in which the scent was felt 5 minutes after the start of energization was selected. The test results are as shown in Table 2 below.

It was confirmed that the use of the drug gel prepared according to the formulation 1 of the present invention clearly has a faster scent and is stronger.
In addition, when a drug gel prepared according to Formula 2 is used, a film with small bubbles is formed and looks bad, whereas when a drug gel prepared according to Formula 2 is used, such a small bubble is formed. I couldn't see it, and it was beautifully liked.

  When the drug gel of the present invention is added to water and stirred, the oily drug held on at least the surface of the drug gel is quickly released and dispersed in water, and the presence of the drug gel itself is effective in stirring in water. In order to improve the efficiency, the oily drug can be quickly and efficiently diffused into the air by adding the drug gel of the present invention to the water in the tank of the drug diffusion device instead of adding the conventional drug directly. Can do. In addition, by devising the shape and color of the drug gel, it is possible to easily design a good appearance, and the behavior of the gel is visible, so that the operation of the device can be confirmed and the appearance is also good. A drug diffusion method having a healing effect can be provided.

DESCRIPTION OF SYMBOLS 1 Drug diffusion apparatus 2 Tank 3 Water absorption pipe 4 Fin 5 Water intake 6 Jet outlet 7 Protective cover 8 Air inlet 9 Air outlet

Claims (4)

  A drug gel, which is a granular gel swollen with water in which an oily drug is held at least on the surface, which is substantially free from a surfactant and is stirred in water.   The drug gel according to claim 1, wherein the granular gel is a water-absorbing polymer swollen with water.   The drug gel according to claim 1 or 2, further comprising a polyhydric alcohol.   A drug diffusion method, wherein the drug gel according to any one of claims 1 to 3 is added to water, and the water and gel are stirred to diffuse the oily drug into the air.

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