JP5141881B2 - Intranasal medication device - Google Patents

Description

  The present invention relates to an intranasal administration device used for intranasal administration of a powdery or liquid drug encapsulated in a capsule.

  For patients with diseases such as rhinitis and nasal allergies, dedicated medication devices are used that spray and administer drugs encapsulated in capsules into the nasal cavity.

  As a conventional intranasal administration device, a capsule storage chamber for storing a capsule encapsulating a powdered drug is disposed between a spray nozzle for the drug and a pressure pump for supplying air to the capsule storage chamber. The drug outlet and air supply port are drilled with pins or blades at one end and the other end of the tube, and the pump is pressed to inject air into the capsule and eject the drug from the nozzle Is known (see, for example, Patent Document 1, Permitted Document 2, and Patent Document 3).

Japanese Patent No. 2881605 Japanese Patent No. 3308425 JP 2004-129823 A

  In the dosing device described in Patent Document 1, after loading a capsule containing a powdered medicine into a capsule storage chamber, an upper outflow hole and a lower inflow hole are formed in the capsule by a long needle provided in the cap by attaching and detaching the cap. It is set as the structure which makes a through-opening in the ejection axis direction. In Patent Document 2, the capsule is loaded into the capsule holder, and at the same time, the first perforation pin provided in the capsule holder is used to pierce the air inlet at the lower part of the capsule and join the chemical spraying portion. A device for opening a medicine outflow hole by reciprocating a movable second drilling pin provided in a medicine spraying section is disclosed.

  In patent document 3, it has a capsule accommodating part arrange | positioned between the spray part of a chemical | medical agent, and a press pump part, and a capsule accommodating part is comprised from the drawer-like capsule insertion / extraction part and the capsule accommodation holding | maintenance part, The medicine outlet and the air inlet are cut and opened by a cutter-like cutting tool at the upper and lower ends of the capsule by being attached to the capsule inlet / outlet and being pushed into the capsule housing / holding part.

However, in any of the above-described devices, an air injection port is formed on one end side of the capsule, and a drug injection port is formed on the other end side of the capsule. There is a possibility that the medicine leaks out from the capsule and accumulates in the air flow path, resulting in insufficient ejection. In other words, the accumulated medicine blocks the air passage from the pressure pump, and it becomes impossible to supply a sufficient amount of air to eject the entire amount of medicine in the capsule by a single pressing operation. There is a problem that it takes time and effort. Therefore, it is necessary to frequently clean the inside of the apparatus, which is inconvenient. In addition, the devices described in Patent Document 1 and Patent Document 2 require operations of at least four steps of loading a capsule, joining a nozzle, and piercing a drilling tool before dosing.
The present invention has been made in view of the problems of the prior art as described above, and preparation of a medicine ejection is completed in one procedure, and accumulation of medicine leaking from the capsule causes the air passage from the pressure pump to be blocked. An object of the present invention is to provide an intranasal dosing device capable of preventing, making a dosing preparation operation simple, and always stably administering an appropriate amount of drug.

Therefore, an intranasal administration device according to the present invention includes an ejection nozzle formed so as to be insertable into the nasal cavity, a capsule housing portion in which a capsule in which a powdery or liquid medicine is sealed, and a capsule housing portion. The invention according to claim 1, further comprising: a pressure pump unit that communicates and blows air into the capsule; and a perforating member that forms an air supply / exhaust hole through which air can enter and exit the capsule. provided with the piercing member only on the nozzle side, the air passage for circulating the air that is blown from the pressing pump unit only ejection nozzle side is provided, wherein the piercing member is is formed in a tubular, the tip tube diameter Is formed to be larger than the shaft tube diameter .

  According to a second aspect of the present invention, in the intranasal administration device according to the first aspect, the piercing member is formed so that the air inlet to the capsule and the drug outlet from which the drug is jetted are formed as a single hole. It is characterized by being configured.

According to a third aspect of the present invention, in the intranasal administration device according to the first or second aspect, the piercing member is formed in a double coaxial manner of the inner tube and the outer tube. .

According to a fourth aspect of the present invention, in the intranasal administration device according to the first or second aspect, the inside of the piercing member is partitioned into two passages (double lumen-like). To do.

According to a fifth aspect of the present invention, in the intranasal administration device according to the first or second aspect, a groove is formed on the outer surface of the piercing member so as to follow the air ejection direction. To do.

According to a sixth aspect of the present invention, in the intranasal administration device according to the first aspect, the piercing member is composed of at least two tubes .

According to a seventh aspect of the present invention, in the intranasal administration device according to the first aspect, the perforating member is composed of at least one rod body and one tube body, and the distal end diameter of the rod body is a shaft portion diameter. It is characterized by being formed larger than.

  According to the present invention, the drug contained in the capsule can be used in powder or liquid form, and is not limited to powder drug.

The present invention has the following excellent effects.
(1) Since the opening is perforated only in the direction in which the medicine is ejected in the capsule in which the medicine is encapsulated, the air passage is prevented from being blocked by the accumulation of powder medicine leaking from the inside of the capsule. An appropriate amount of drug can be stably administered.
(2) The medicine in the capsule can be efficiently ejected into the nasal cavity without waste.
(3) There is no accumulation of chemicals in the ventilation path, and there is no need to frequently clean the inside of the apparatus.
(4) The possibility of obstructing the ejection of the medicine due to the obstruction of the vent due to the runny nose is eliminated.
(5) The medication preparation operation is simplified.

Next, embodiments of the present invention will be described based on examples shown in the drawings.
1 to 3 are longitudinal sectional views showing an embodiment of an intranasal medication device according to the present invention, FIG. 4 is an exploded perspective view of a main part of the intranasal medication device according to the present invention, and FIG. FIG. 6A is a longitudinal sectional view showing another embodiment, FIG. 6B is a transverse sectional view, FIG. 6A is a longitudinal sectional view showing another embodiment of the perforated member, FIG. ) Is a longitudinal sectional view showing another embodiment of the piercing member, (b) is a transverse sectional view, FIG. 8 (a) is a longitudinal sectional view showing another embodiment of the piercing needle, (b) is a transverse sectional view, FIG. 9 is a longitudinal sectional view of a main part showing a perforation pattern, FIG. 10 is a longitudinal sectional view showing another embodiment of the press pump section, and FIG. 11 is a longitudinal sectional view showing another embodiment of the press pump section and the ejection nozzle. is there.

  As shown in FIGS. 1 to 4, a capsule K in which a powdery medicine 7 is sealed can be loaded in the capsule holding portion 6 of the capsule holder 8 of the intranasal medication device S according to the present invention. When the cap 1 to which the ejection nozzle 2 formed so as to be insertable into the nasal cavity is connected to the distal end side of the capsule holder 8, the piercing member (piercing needle) 4 provided in the cap 1 pierces the capsule K. The air supply / exhaust hole H1 is opened. Here, the perforating member 4 is formed in a tubular shape with a sharp tip, and the tube diameter of the tip portion 4a is formed larger than the tube diameter of the shaft portion 4b. A hole H1 having the same diameter as the diameter of the portion 4a is opened, but when the cap 1 is further pushed in, a gap Z is formed between the edge of the opened hole H1 and the outer surface of the shaft tube portion 4b of the piercing member 4. (Exhaust passage 5b) is formed.

  That is, according to the device S of the present invention, the capsule K is provided with the air supply / exhaust hole H1 through which the air pushed out from the pressure pump 14 can enter and exit only on the ejection nozzle 2 side. In addition, the cap 1 and the capsule holder 8 are provided with air passages 5 and 8 a through which the air A <b> 1 supplied from the press pump 14 flows only to the ejection nozzle 2 side.

  Further, the lower end of the capsule holder 8 is connected by a cylindrical connecting member 11 having an end partition wall 13 having a substantially inverted cone-shaped skirt portion that is fitted and fixed to the pressure pump 14 in a sealed state. An air chamber 11b is formed in the connecting member 11, an air passage 12 for introducing outside air 16 from both sides of the air chamber 11b, and an air inlet 15 through which the air blown from the pressure pump 14 flows into the air chamber 11b. Then, a vent hole 11 a for feeding this fumarole to the lower end of the capsule holder 8 is drilled.

  Furthermore, the first movable valve 10 that can move up and down in the air chamber 11b is accommodated in the air chamber 11b. Similarly, a recess 8b opened downward is formed at the lower end of the capsule holder 8, and a disc-shaped second movable valve 9 capable of moving up and down the recess 8b is accommodated. Here, the first movable valve 10 is provided with a flange portion 10b around it, and a vent hole 10a is formed in the center thereof.

  When the pressure pump 14 is pressed and blown, the first movable valve 10 sitting on the end partition wall 13 of the connecting member 11 and closing the air flow inlet 15 is lifted, and the air intake path 12 of the air chamber 11b is the first. Closed by the flange 10b of the movable valve 10, the fumarole A1 passes through the vent hole 10a and the vent hole 11a of the first movable valve 10, pushes up the second movable valve 9 upward (in the direction of the arrow W1), and capsule holder 8 The air is divided into the air supply passage 5 of the cap 1 through the air passage 8a, and is supplied downward (in the direction of arrow Y1) through the air supply passage 5a in the piercing member 4, and is injected into the capsule K. . As a result, the drug 7 in the capsule K rises upward (in the direction indicated by arrow Y2) while diffusing, and is discharged from the ejection nozzle 2 through the air passage 3 of the cap 1 from the gap Z (exhaust passage 5b) and sprayed into the nasal cavity. Is done.

  Here, when the pump 14 narrowed by the pumping operation is restored (in the direction of arrow X2), the second movable valve 9 is sucked downward at the same time as the outside air is sucked, whereby the vent hole 11a is closed and the first movable valve is closed. The valve 10 is seated on the end partition wall 13 of the press pump 14, the closed intake passage 12 is opened again, and the outside air 16 is sucked into the pump 14.

  Hereinafter, although other examples of intranasal medication device S concerning the present invention are shown, the same referential mark is attached and explained to the same component as Example 1 for convenience.

  As shown in FIG. 5, by forming the punching member 4 for opening the air supply / exhaust hole H1 in the capsule K in a double coaxial manner of the inner tube 4e and the outer tube 4f, the inner tube 4e and the outer tube 4f are formed. FIG. 6 shows a configuration in which the air supplied from the gap (air supply path) 5a flows into the capsule K and flows out so that the medicine 7 in the capsule K is pushed out from the exhaust path 5b of the inner tube 4e. Similarly, the air supplied to the inner tube 4e can flow into the capsule K and be discharged so that the medicine 7 in the capsule K is pushed out from the gap 5a.

  As shown in FIG. 7, by forming the inside of the piercing member 4 for opening the air supply / exhaust hole H1 in the capsule K into at least two passages 5a and 5b (double lumen-like) by the partition wall 4d, It is also possible to adopt a configuration in which the air fed into one passage 5a flows into the capsule K and flows out so as to push out the medicine 7 from the other passage 5b.

  As shown in FIG. 8, the punching member 4 for opening the air supply / exhaust hole H1 in the capsule K is formed in the shape of a single tube 4e in which grooves 4g are formed on the outer surface of the capsule K along the air ejection direction. A configuration in which air sent through the air supply path 5a formed by the groove 4g flows into the capsule K and flows out so that the medicine 7 in the capsule K is pushed out from the exhaust path 5b of the single tube 4e; Or conversely, the air sent into the single tube 4e may flow into the capsule K and flow out so that the medicine 7 in the capsule K is pushed out from the groove 4g.

  As shown in FIG. 9A, the piercing member 4 for opening the air supply / exhaust hole H1 in the capsule K is composed of at least two adjacent pipe bodies 4e and 4f, and air is supplied to one pipe body 4e. It is also possible to adopt a configuration in which the air A1 thus flowed flows into the capsule K and the medicine in the capsule is pushed out together with the air A2 from the other tube body 4f. Further, as shown in FIG. 9B, the piercing member 4 for opening the air supply / exhaust hole H1 in the capsule K is composed of a rod body 4h and a tube body 4e, and the rod diameter of the tip end portion of the rod body 4h is pivoted. It is formed larger than the part bar diameter. By this rod 4h, an air supply / exhaust H1 through which air A1 can enter and exit the capsule K is established, and a gap Z is formed between the edge of the air supply / exhaust H1 and the outer surface of the shaft portion of the rod 4h. The Then, the air A1 sent to the tube 4e flows into the capsule K, and the medicine 7 in the capsule K is pushed out together with the air A2 from the gap Z, or as shown in FIG. Alternatively, the air A1 fed into the gap Z may flow into the capsule K and the medicine 7 in the capsule K may be pushed out from the tube 4f.

[Experimental Example 1]
The capsule was loaded into the dosing device, and the ejection rate was measured by the number of pumping pumps.
In this experiment, 60 mg of calcium carbonate powder was sealed in a No. 2 size (capacity 0.37 ml) capsule. Table 1 shows the results of the experiment conducted with the single nozzle type shown in FIG. 10, and Table 2 shows the results of the experiment conducted with the double nozzle type having the two nozzles 2a and 2b shown in FIG. The outer diameter of the tube portion at the tip of the piercing needle 4 is 1.25 mm, the outer diameter of the shaft tube portion is 0.9 mm, and the gap width between the edge of the opening drilled in the capsule K and the middle shaft portion is 0. .175 mm. Here, the intake valve 10a is provided in order to suck the outside air into the pressure pump 14a which is narrowed by the pumping.

  As shown in Tables 1 and 2, according to the present invention, 90% or more of the powder in the capsule can be ejected by the first pumping, and no powder was leaked into the administration device. .

  The single nozzle type can be selectively administered to the other nasal cavity when one of the nasal cavity causes a nasal congestion or runny nose. Moreover, it is possible to make a double-nozzle administration device only by changing the nozzle portion.

It is a longitudinal cross-sectional view which shows one Example of the intranasal medication apparatus which concerns on this invention. It is a longitudinal cross-sectional view which shows one Example of the intranasal medication apparatus which concerns on this invention. It is a longitudinal cross-sectional view which shows one Example of the intranasal medication apparatus which concerns on this invention. It is a principal part disassembled perspective view of the intranasal medication apparatus concerning this invention. (A) is the longitudinal cross-sectional view which shows the other Example of a piercing needle, (b) is a cross-sectional view of a piercing | piercing. (A) is the longitudinal cross-sectional view which shows the other Example of a piercing needle, (b) is a cross-sectional view of a piercing | piercing. (A) is the longitudinal cross-sectional view which shows the other Example of a piercing needle, (b) is a cross-sectional view of a piercing | piercing. (A) is the longitudinal cross-sectional view which shows the other Example of a piercing needle, (b) is a cross-sectional view of a piercing | piercing. It is a principal part longitudinal cross-sectional view which shows a drilling pattern. It is a longitudinal cross-sectional view which shows the other Example of a press pump part. It is a longitudinal cross-sectional view which shows the other Example of a press pump part and a jet nozzle.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Cap 2 Ejection nozzle 2a Ejection nozzle 2b Ejection nozzle 3 Fumarole path 4 Perforation member (perforation needle)
4a Front tube portion 4b of the piercing member 4b Shaft tube portion 4c of the piercing member 4d rear end tube portion 4d Partition wall 4e of the piercing member Inner tube (or single tube) of the piercing member
4f Outer tube (or single tube) of perforated member
4g Groove 4h of piercing member Rod body 5 of piercing member 5 Air supply path 5a Air supply path 5b Exhaust path 6 Capsule accommodating portion 7 Drug 8 Capsule holder 8a Air supply path 8b Recess 9 Second movable valve 10 First movable valve 10a 1st movable valve vent 10b 1st movable valve collar 11 Capsule holder and press pump connecting member 11a connecting member 11a connecting member vent hole 11b air chamber 12 inlet passage 13 end partition 14 press pump 14a press pump 15 connecting member Air inlet 16 Outside air K Capsule H1 Supply / exhaust hole Z Gap

Claims (7)

An ejection nozzle formed so as to be insertable into the nasal cavity, a capsule housing portion filled with a capsule filled with a powdery or liquid medicine, communicated with the capsule housing portion, and air is blown into the capsule In the intranasal medication device comprising a pressing pump unit that performs and a perforating member that forms an air supply / exhaust hole through which air can enter and exit from the capsule, the perforating member is provided only on the ejection nozzle side, and from the press pump unit An air passage is provided for circulating the air to be fed only to the ejection nozzle side , and the perforated member is formed in a tubular shape, and its tip end pipe diameter is formed larger than the shaft pipe diameter. Intranasal dosing device characterized. 2. The intranasal administration device according to claim 1, wherein the piercing member is configured so that the air inlet to the capsule and the medicine outlet from which the medicine is ejected become a single hole. The intranasal administration device according to claim 1 or 2, wherein the perforating member is formed in a double coaxial manner of an inner tube and an outer tube . The intranasal administration device according to claim 1 or 2 , wherein the inside of the piercing member is divided into two passages (double lumen-like) . The intranasal medication device according to claim 1 or 2, wherein a groove is formed on the outer surface of the piercing member along the direction of air ejection . 2. The intranasal administration device according to claim 1, wherein the piercing member is composed of at least two tubes . Piercing member is composed of at least a pair of rods, claim 1 tip shaft diameter of one of the rods is formed larger than the shaft portion diameter, the other rod is characterized straight tubular der Rukoto The intranasal dosing device as described.

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