JP5086377B2 - A micro-bubble generating device in which the micro-bubble particle size and the micro-bubble concentration are variable, and a method for changing (scaling up / down) the micro-bubble generating device using the device. - Google Patents

Description

  The present invention relates to a microbubble generator called microbubble and nanobubble.

  It is said that so-called “microbubbles” have different properties from ordinary bubbles. This “microbubble” is a low concentration type: there is a distribution peak around 30 μm in diameter, and the bubble concentration is about several hundreds / mL. It looks like a little cloudy water. And high-concentration type: There is a bubble distribution peak near 10μm, and the number of bubbles is more than several thousand / mL. It looks like milk.

  Here, the difference in the effect on the desired organism or non-organism due to the difference in bubbles such as the low concentration type (30 μm) and the high concentration type (10 μm) is varied and cannot be generally described.

  In other words, for organisms such as oysters, fish and humans, the high concentration type (10 μm) is a low concentration type (10 μm) that promotes the uptake of foreign substances (endocytosis) and has a health promoting effect such as increased blood flow. It is much larger than that of 30 μm).

  On the other hand, for a single cell of a living organism such as fibroblasts, osteoblasts, and E. coli, single-celled organisms, or micro organisms such as corals, scavengers against radicals that are thought to be generated by high concentration type (10 μm) bowling. Since the defense means such as generation is weak, the high concentration type (10 μm) is not always good.

  In this case, conversely, a low-concentration type (30 μm) region area that is more effective than normal millimeter-scale bubbling is found experimentally and used.

  In other words, when microbubbles called microbubbles and nanobubbles are put to practical use, the relatively large organisms (oysters, fish, and human bodies) are microscopically called the high-concentration type (10 μm). Although the bubble size distribution is relatively small and the concentration of microbubbles may be high, one cell or single cell organism such as fibroblast, osteoblast or E. coli, or coral When targeting micro-organisms such as, because the defense of the body such as radical scavenger generation is fragile, the desired effect of promoting or activating foreign body uptake (endocytosis) cannot be obtained, rather, Since it has adverse effects such as cell destruction and sterilization, it is necessary to search for an effective area with a low concentration type that is close to normal millimeter-scale bubbling. .

  Of course, in the latter case, there is no problem if the desired effects such as cell destruction and sterilization are achieved. For example, the use of microbubbles and nanobubbles has been proposed for combating influenza viruses and killing antibiotic-resistant bacteria such as MRSA, and these are considered to be better in high concentration type (10 μm).

  The inventor has proposed a wider range of applications. In other words, in addition to sterilization and disinfection applications, the promotion and activation of foreign body uptake (endocytosis) for single cells of single organisms such as fibroblasts, osteoblasts, and E. coli, single cell organisms, and micro organisms such as corals We are also studying ways to make this possible.

  A technique for generating high-concentration type (10 μm) microbubbles is described in Patent Document 1, for example. On the other hand, a low-concentration type (30 μm) or a lower (millimeter-scale) type device having a larger bubble diameter is described in Patent Document 2, and a device including applications is described in Patent Document 3.

  There is also a brief explanation on the microbubble generator on the public web (http://staff.aist.go.jp/m.taka/Research.html) of Masayoshi Takahashi of AIST. Here, the description of the relevant part as of December 2009 is reprinted as follows.

<Quotation> (http://staff.aist.go.jp/m.taka/Research.html)
There are three main types of microbubble creation methods.

  A) Method of using chemicals: This may include the generation of gas by chemical reaction, but microscopically utilizing the phenomenon that bubbles are precipitated from the crevice between crystals when pumice-like galactose is dissolved in water. How to generate a bubble. Particular feature is the use of palmitic acid as a stabilizer for bubbles, and it is used as an echo source in ultrasound diagnosis in the medical field. After preparing in a small bottle, it is sent into the blood vessel with a syringe. Do tens of minutes exist as bubbles in the body? When it hits the ultrasonic wave, the bubble vibrates and sends back the ultrasonic wave. By detecting this, blood flow can be measured. Research has been done on diagnosing cancer and destroying cancer cells using the phenomenon that occurs when bubbles break.

  B) Using supersaturation: Gases such as oxygen dissolve in water. The amount of gas to be dissolved varies depending on the type of gas, but the basic characteristic is that the amount of gas to be dissolved increases in proportion to the pressure. The microbubble generation method called the pressure dissolution (pressurization / decompression) method uses this property. In other words, if a sufficient amount of gas is dissolved in water at a certain high pressure and then the pressure is released, the water will be called supersaturated (relative to the dissolved gas). This is a very unstable state, so the supersaturated gas molecules try to jump out of the water. As a result, a large amount of bubbles can be generated in the water. (Since this bubble (gas phase) generation has a slightly complicated mechanism, I would like to introduce it one day.) With this mechanism, the pressure-dissolving type microbubble generator continuously generates microbubbles. It is possible to. In addition, it seems that there are many machines that use about 4 atm as pump extrusion pressure. I think this pressure is probably the most efficient. There seems to be know-how in generating fine bubbles from supersaturated water. If this doesn't work, the concentration of bubbles may be low, or the microbubbles that are generated will be too large.

  C) Gas-liquid two-phase flow swirl method: Microbubbles can be created by stirring water and gas. Various methods are used, but all have a common point, and the secret of microbubble generation is hidden there. The point is the effect of entraining the gas in the vortex, stopping the vortex, and releasing the entrained gas. Hydrodynamic studies are a topic for the future, but this type of microbubble generator includes this mechanism. On the other hand, it is possible to make microbubbles easily by including this mechanism. However, there is an important point in how the gas is entrained in the vortex, and if it does not work well, microbubbles will not be generated. The point seems to have know-how. As a method of stopping the eddy current, it is possible to stop the eddy current by using an obstacle or by ejecting it into the relatively stopped bulk water.

  There are two types of microbubble generators of this type. One is to generate a water flow using a pump and to generate a vortex using a rotary drive (such as a bell or a circular inclined plate). In this case, simply making the gas self-sufficient does not generate dense microbubbles. On the other hand, when the pressure at the nozzle is released by making good use of the pump drive pressure, it is possible to generate very dense microbubbles. The other type has a shaft in the cylinder and agitation of water and gas with a propeller attached to the shaft. This type can generate only a low concentration of bubbles, but since the gas and liquid are mixed directly, the water flow is large, and as a result, microbubbles can be generated very efficiently. There is little risk of clogging with floating substances, and it is not affected by subtle pressure fluctuations, so it is recommended for practical use such as improving the environment of closed water areas.

<End of quotation> (http://staff.aist.go.jp/m.taka/Research.html)
Reviewing the device of Patent Document 1 in light of the above citation, this is a clever device that skillfully combines B) a method using supersaturation and C) a gas-liquid two-phase swirl method. Conceivable.

  The present inventor analyzed this apparatus, and reached the present invention by trial and error of a method for easily adjusting the particle size and amount (concentration) of microbubbles (nanobubbles).

  This is because, as motivation, a method of easily adjusting the particle size (particle size distribution) and amount (concentration) of microbubbles (nanobubbles) is important in practical use.

  Here, its importance will be explained. In the above description, the description of high concentration type (10 μm) and low concentration type (30 μm) roughly categorizes the particle size (particle size distribution) and amount (concentration) of microbubbles (nanobubbles), Strictly speaking, there are two data, that is, the particle size (particle size distribution) and the amount (concentration) of a plurality of bubble generation type micro bubble generation devices and / or the input energy limit (device capacity) in the same bubble generation method. It must be collected by different microbubble generators.

  These data measurements have good optical techniques and are available on the market. As such measuring devices, there are products such as a particle measuring instrument KL-30A in the liquid phase of Rion Corporation, a light scattering particle counter in liquid from Particle Measuring Systems, and an in-liquid particle counter APSS-200 from Sysmex. Some of the manufacturers of microbubble generators have released measurement data on the particle size (particle size distribution) and amount (concentration) of microbubbles produced by commercial microbubble generator products using these measuring instruments. ing.

  Patent Documents 4 to 20 mainly obtain microbubbles having a nanoscale particle size which is electrochemically stable in a liquid without crushing, starting from microbubbles, and applying various effects peculiar to such nanobubbles. Proposals have been made.

  However, there is no description about adjusting the particle size distribution and concentration of micro / nano and micro / nano bubbles which are intermediate between them.

  Patent Documents 21 to 26 are proposals for improving the microbubble generator proposed by the inventor of the present invention, and for microbubble applications such as culturing one cell of a living organism, cell change, and the like. Some of these have combined use with the present invention. This will be described later.

Non-Patent Documents 1 to 5 are technical explanations of microbubbles and nanobubbles, and Non-Patent Document 5 is relatively latest information. I want to be referred.
Japanese Patent No. 3620797, “Microbubble generator”, IPMS Japanese Patent No. 2762372 “Microbubble Generator” Komatsu Ltd. Japanese Patent Publication No. 5-60353 “Culture method and apparatus by aeration in liquid” Hitachi, Ltd. JP 2009-189307 A “Sterilization or Inactivation Method of Spore Bacteria” JP 2009-131770 “Method for producing carbon dioxide nanobubble water” JP 2009-131769 A “Method for Producing Nitrogen Nanobubble Water” JP 2009-084258 A "Drug for treatment or prevention of cancer containing nanobubbles" Japanese Unexamined Patent Publication No. 2009-039600 “Ultrafine Bubble Generation Device” JP 2008-259456 A “Method for Preserving Seafood” JP 2008-237950 A “Method for producing water containing hydroxyl radicals and water containing hydroxyl radicals” JP 2008-093612 A "Method for producing water containing reactive active species and water containing reactive active species" JP 2008-093611 A "Method for producing water containing extremely fine bubbles and water containing extremely fine bubbles" JP 2008-063258 A "Tissue preservation solution" JP 2007-275089 A "Long-lasting ozone water, environmental sterilization / deodorizing purification method using long-lasting ozone water" Japanese Patent Application Laid-Open No. 2006-223239 “A method for extracting active ingredients of roasted seafood using oxygen nanobubbles and a processed fish meat material to which active ingredients obtained by the extraction method are added” Japanese Patent Application Laid-Open No. 2005-246294 “Oxygen Nano Bubble Water and Method for Producing the Same” Japanese Patent Application Laid-Open No. 2005-246293 “Ozone water and method for producing the same” JP 2005-245817 A “Method for producing nanobubbles” Japanese Patent Application Laid-Open No. 2005-110552 “Pressurized Multilayer Micro-Ozone Sterilization / Purification / Animal Sterilization System” No. 2005/030649 publication "Crushing of microbubbles" Japanese Patent Application No. 2009-234683, “Composition containing microbubbles for promoting cell change, apparatus for producing the composition containing microbubbles, and method for promoting cell change using the composition containing microbubbles” Tomotaka Marui Japanese Patent Application No. 2009-243940 “Composition of microbubbles and microbubble generator” Tomotaka Marui Japanese Patent Application No. 2009-249900 “Apparatus for generating microbubbles in liquid” Tomotaka Marui Japanese Patent Application No. 2009-282840 “A device for promoting cell change with a liquid composition containing microbubbles and a method for promoting cell change with a liquid composition containing microbubbles” Tomotaka Marui Japanese Patent Application No. 2009-265832 “Apparatus and method for generating heat by generating microbubbles in liquid” Tomotaka Marui Japanese Patent Application No. 2009-294499, “System for Promoting Carbon Dioxide Absorption by Ground Plants and Underwater Plants, Method for Promoting Carbon Dioxide Absorption by Plants” Tomotaka Marui Ichiro Nagao, Ken Muramatsu, Kenji Sato “Histological study on tissue preservation of oxygen nanobubble water (1st report)” The 111th Annual Meeting of the Japanese Anatomy Society 2005 New Energy and Industrial Technology Development Organization Commissioned Research Study Survey on Industrial Use of Nano Bubble Water in Biotechnology Results Report 38-40 “Evaluation Research on Preservation of Living Tissue Using Nano Bubble Water” Hojo Y, et al. “Anti-inflammability Property of Oxygen Nano-bubbles” Circulation Journal vol. 70, supplement I, p276 (The 70th Annual Meeting of the Japanese Circulation Society) 2005 New Energy and Industrial Technology Development Organization Commissioned Research Study on Industrial Use of Nano Bubble Water in Biotechnology Results Report 40-45 “Evaluation of Nano Bubble Water Effects on Cell Physiology” The Multiphase Flow Lecture Series 35th “The Characteristics of Micro / Nano Bubbles and Their Applications” December 5, 2009 (distributed at Kansai University)

  An object of the present invention is to generate microbubbles (microbubbles / nanobubbles) generated by a microbubble generator in order to increase the application targets in applications of microbubble generation for living organisms or microbubbles for non-living organisms. ) To change physical characteristics such as bubble particle size distribution and bubble concentration.

The present inventor recognizes that it is important to change physical characteristics such as the bubble particle size distribution and the bubble concentration, and in Patent Document 1, “B) a method using supersaturation, and C) The research was carried out with a practical device that realized a skillful combination of the "liquid two-phase flow swirl method". (Refer to “Technical field” for (B) C))
First, the apparatus of Patent Document 1 will be outlined in FIG. 2 and FIG. 3 which are photographs of the actual state of the discharge nozzle shown in the patent diagram of FIG. 1 and its practical apparatus. Since details are described in Patent Document 1, only the discharge nozzle will be described below, and the other configurations will be omitted here.

  The discharge nozzle of the practical device is composed of the members shown in the disassembled situation photographs in FIGS. 2 and 3, and specifically has the configuration shown in FIG.

  That is, the supersaturation is promoted by pressurizing the liquid mixed with gas (supersaturated) introduced from the lower left of FIG. 8 by a vortex pump (not shown) by the pressurizing means 40 such as 45, 46, 47, etc. .

  More specifically, 45, 46, 47 and the like are flow obstruction members that partially block the cross section of the liquid flow passage 42.

  Using this practical apparatus, the experiments shown in FIGS. 6 and 7 were conducted with particular attention to the discharge nozzle portion. The discharge nozzle used here does not have a hollow cylinder, which is a collision member that causes the jet-like discharge liquid discharged from the central portion 50 in FIG. (See FIG. 9. The discharge nozzle of FIG. 10 has almost the same result.)

The experiment in FIG. 6 is a reference experiment. For the experiment and its contents, refer to the section “Brief description of the drawing” in the figure. From this result, the following reference device was recalled.

In other words (see reference device , Fig. 4), generation of microbubbles by the pressure dissolution (pressurization / depressurization) method in which gas is supersaturated and mixed into liquid at high pressure, and then stimulated to appear as microbubbles and ejected by liquid ejection means In the apparatus, the pressurizing means for bringing the liquid included in the generating device into a high-pressure state is a flow obstruction member that partially closes a cross section of the liquid flow passage inside the liquid discharge means, and One or more flow obstruction members are arranged in the liquid flow passage inside the liquid discharge means, and further comprises means for moving at least one position of the flow obstruction member. A microbubble generator having variable particle size distribution and concentration, characterized in that the microbubble particle size distribution and microbubble concentration are adjusted by a change in liquid flow caused by movement of a moving means.

For this reference device , see FIG. 4 and the section “Brief description of the drawing” in the figure.

Next, the experiment of FIG. 7 related to claim 1 was conducted. For the experiment and its contents, refer to the “Short description of drawings” section of the figure. (Refer to FIG. 9 for the discharge nozzle used. The discharge nozzle of FIG. 10 has almost the same result.) From this result, claim 1 is recalled.

That is, (refer to claim 1 and FIG. 5), a microbubble of the pressure dissolution (pressurization / depressurization) method in which a gas is supersaturated and mixed in a liquid at high pressure, and then is stimulated to appear as a microbubble and ejected by a liquid ejection means. In the generator, a flow guiding path for stimulating the supersaturated mixed gas included in the generator to form microbubbles is disposed inside the liquid ejecting means, and changes the flow direction of the liquid substantially at right angles, and A collision member disposed at a discharge portion of the liquid discharge means, which collides with a jet-like liquid discharged from the guide path and changes the liquid flow direction to a substantially right angle again, and the flow guide path Moving means for moving the position of the liquid so that the liquid flow direction is not substantially perpendicularly changed, and / or moving the position of the collision member so that the liquid flow direction is not substantially perpendicularly changed. Means Provided La, a microbubble generating apparatus particle size distribution and density is variable, which was characterized by adjusting the microbubbles size distribution and microbubble concentration by changes in liquid flow due to movement of the mobile unit.

For this embodiment, see FIG. 5 and the section “Brief description of the drawings” in the figure. See also FIG. 11 for a reference diagram of claim 1 .

  As described above, the combination of the present invention and Patent Documents 23, 24, and 25 filed by the inventor is also important.

  First, Patent Document 23 discloses that good bubbling is achieved by controlling the rotational speed of the pump motor. The control system is also disclosed in FIG. 6 and FIG.

  This can be combined with the present invention. That is, in the present invention, it is claimed that adjustment is made to good bubbling by a change in the internal configuration of the discharge nozzle, but there is a limit only by the internal configuration of the discharge nozzle. Since the change in the rotational speed of the pump motor in Patent Document 23 gives yet another control parameter, the combination with this technique is effective.

  Next, Patent Document 24, which is a bubble utilization technique for cell change such as iPS cellization in particular, emphasizes the importance of temperature in this application. Specifically, “18A ”Discloses the provision of control means for the temperature (including other pressure, ion concentration, etc.) of the liquid tank that discharges microbubbles.

  This also means that, when applying the present invention to a single cell or a micro organism in a living body, how to alleviate biological shock due to temperature is practically important. It is indispensable to control the tank and use the data collection parameter as to how many times the temperature of the liquid is for the internal change of the discharge nozzle of the present invention.

  Therefore, the use in combination with the temperature control means disclosed in Patent Document 24 is practically effective, and is essential if cells are targeted.

  Patent Document 25 is similar to Patent Document 24 in terms of temperature. That is, since the bubbling itself generates heat in the temperature control described above, it is preferable to implement the heat generation technique disclosed in Patent Document 25 in various applications.

  Patent Documents 23, 24, and 25 disclose a system in which a sensor for evaluating a bubbling situation is incorporated. In practice, it is preferable to add the means for moving the position of the member inside or around the discharge nozzle of the present invention to the actuator by an optical sensor or acoustic sensor (Patent Document 25) in real time because the control becomes stable.

  That is, as an indirect control target of the bubbling control system disclosed in Patent Documents 23, 24, and 25, the system improvement using the discharge nozzle-related moving means of the present invention is suitable.

Based on these, a change design method (scale-up / scale-down) of the microbubble generator using the microbubble generator according to claim 2 is proposed. This is a method for scaling up the results of a small, experimental bubbling device to a practical scale.

That is, ( Claim 2 ), a plurality of microbubble generators having different bubble generation methods and / or a plurality of microbubble generators having different input energy limits (device capacities) in the same bubble generation method, A first step of preparing a database of the particle size distribution of the microbubbles generated by the microbubble generator and the concentration range of the microbubbles, and a desired method using the microbubble generator having variable particle size distribution and concentration according to claim 1 The second step of extracting the particle size distribution of the microbubbles and the concentration range of the microbubbles that have an effect on the living organism or the non-living organism, the microscopic portion that can obtain the influence on the desired organism or non-living organism obtained in the second step Both the bubble size distribution and the microbubble concentration range, and the microbubble size distribution generated by the plurality of microbubble generators in the database prepared in the first step and the microbubble concentration range are both The third step of extracting similar ones gives a desired organism or non-living body with different bubble generation methods and / or microbubble generation devices with different input energy limits (device capacity) in the same bubble generation method This is a method for designing a change (scale-up / scale-down) of the microbubble generator in anticipation of the effect.

  Even in such a method, it is ideal to use the temperature and other physical quantities disclosed in Patent Documents 23, 24, and 25 as parameters as a database.

  As a supplement, since temperature changes physical properties such as density and viscosity (viscosity coefficient) of the liquid to be bubbled as well as the above-mentioned biological shock problem, it is extremely important to fix the temperature conditions properly. That's it.

  Temperature may be one of the causes of the lack of reproducibility in conventional microbubble applications. Therefore, in the practice of the present invention, attention should be paid to the management of the liquid temperature.

  According to the present invention, representative physical characteristics such as the bubble particle size distribution and bubble concentration of microbubbles (microbubbles / nanobubbles) generated by a pressure bubble (pressure / decompression) method are rapidly changed. be able to. This is effective in both the application of microbubbles for living organisms and the application of microbubbles for non-living organisms.

  This is because if the typical physical characteristics such as the bubble particle size distribution and the bubble concentration are different, the effect is remarkably different even if the target is a living organism and the target is a non-living subject.

  In a simple example, a cell is activated by nanobubbles, but in a microbubble, the cell membrane is destroyed by the bactericidal action of radicals generated by crushing. If the particle size distribution can be changed, it is possible to activate / proliferate good cells and kill bad cells.

  Of course, not only the particle size distribution but also the concentration and temperature are important factors. Regarding the latter temperature, in the present invention, as a requirement of the device patent, the liquid temperature control means is further combined. However, it is technical common sense that organisms are sensitive to temperature. Absent.

Further, the method described in claim 2 has the following effects. In general, for unknown applications, it will usually be tried first with a small device. With the present invention apparatus in the trial experimental apparatus, as a parameter, since experiments Tsu Fu particle size distribution and density is easily performed, the most appropriate conditions are likely to extract the application target.

  On the other hand, if the particle size distribution / concentration of the generated bubbles in a large apparatus is known, there is an effect that it is easy to select a large size that fits a small case.

  In general, the present invention can broaden the practical applications of micro-nano bubbles and micro-nano bubbles, which are intermediate between them.

Further, as a small variation of the present invention, as a configuration around the discharge nozzle, a cylindrical body in which a flow obstacle 64 is further arranged on a part of the open circular surface 62 of FIG. Alternatively, an embodiment provided with means for moving either of them in the vertical direction of the drawing in combination with the configuration of FIG. 10 is also effective.

FIG. 3 of Patent Document 1 is an explanatory diagram relating to a discharge nozzle (41 or 22) which is a “liquid discharge means” of the present invention. (Photo) A disassembled photo of the discharge nozzle (41 or 22), which is the “liquid discharge means” of the microbubble generator product that implements Patent Document 1. (Photo) An enlarged view of a part of the dismantled photograph of FIG. 2, which is a photograph of a member obtained by laminating a three-hole orifice and a mesh (mesh) plate which are the “pressurizing means 40” of the present invention. It is an example figure of a reference device , Comprising: The clearance gap 48 between several 40 which changes with the movement of the moving means 44 is shown. Here, the moving means is illustrated as having a male screw and a female screw. As the screw turns, 43 moves up and down in the figure to widen or narrow the gap 48. This change changes the pressurization pressure and flow mode, and changes the microbubble particle size distribution and microbubble concentration. (A) is a state where the gap is widened, and (b) is a state where the gap is narrowed. In the latter case, milky-like microbubbles are observed, so it is considered that the particle size distribution is shifted to the smaller particle size side. A illustration of the merits invention according to claim 1, regulates whether or not to change the jet-like discharge flow vector 55 of liquid location discharged from 50 by moving means 52 for moving 51 to 53. This change becomes the intensity of stimulation given after gas is supersaturated in the liquid at high pressure, and changes the microbubble particle size distribution and microbubble concentration. Here, 52 is exemplified by a combination of push-up by fluid pressure and pull-down by spring. (A) is a state where the position of the collision member is moved so that the liquid flow direction is not substantially perpendicularly changed, and (b) is a case where the jet-like liquid discharged from the guide path collides with the collision member 51 and again. The state in which the liquid flow direction is changed to a substantially right angle. In the latter case, milky-like microbubbles are observed, so it is considered that the particle size distribution is shifted to the smaller particle size side. It is a figure explaining reference experiment, Comprising: (a) Preparatory state, 45 (an example of 40 which is a 3-hole orifice) or 46 (an example of 40 which is a metal net (mesh)) or 47 (resin) A part of the gap was widened by laminating a net (an example of 40 which is a circular plate having a large number of holes). (B) The vortex pump was turned on, but there was not much milky foam due to the gap expansion. The state of deviation from the so-called high-concentration particle size distribution and concentration. (C) Therefore, the gap was filled with metal cutting waste. As a result, milky-like bubbles appeared, approaching a so-called high concentration type particle size distribution. (D) Further, when 40 was additionally inserted into the gap, a Milky-like bubble was similarly produced, approaching a so-called high concentration type particle size distribution. FIG. 2 is a diagram for demonstrating the effect of claim 1 of the present invention with a simpler system, and when a nozzle is surrounded by a hand-cylinder-shaped cylindrical body 60 in which one circular surface is closed, a milky-like bubble appears, It approached the so-called high concentration type particle size distribution. The schematic diagram which redrawn the discharge nozzle of patent document 1 based on the actual condition illustrated in FIG. The schematic diagram of the nozzle which removed the collision member (cylindrical body which has a curved surface in a cylinder) of the discharge nozzle of patent document 1 shown in FIG. The schematic diagram of the nozzle which removed the site | part of the flow induction path 50 which changes the liquid flow direction in the nozzle of FIG. FIG. 10 is a schematic diagram of an embodiment using a cylindrical body 60 with one circular surface blocked (nozzle shape) in the nozzle (54) of FIG. 9, and in FIG. Has already moved and the jet-like liquid (vector 55) discharged from the guide path flows without colliding. For this reason, the particle size distribution of the bubbles is not stimulated and is shifted to a relatively large particle size. In (b), since the jet-like liquid (vector 55) discharged from the guide path collides with the inner surface of the cylinder 60 having a collision portion and is stimulated to generate more microbubbles, the particle size distribution of the bubbles is relatively high. The particle size is shifted to a smaller one, and the concentration is also high. The schematic diagram of the embodiment of the cylindrical body which further arrange | positioned the flow obstruction 64 in some open circular surfaces 62 of 60. FIG.

40 Pressurizing means for bringing the liquid into a high pressure state, more specifically, a flow obstruction member 41 that partially closes the cross section of the liquid flow passage 42, and the liquid discharge means of the microbubble generator 20 (same as 22)
42 Flow direction vector 43 of liquid flow path inside liquid discharge means (41 or 22) Example of flow obstruction member 40 movable by moving means 44 (example of 46 metal mesh (mesh))
44 Moving means 45 for moving the position of the flow obstruction member 40 Example of 40 which is a three-hole orifice 46 Example of 40 which is a metal net (mesh) 47 Example of 40 which is a resin net (circular plate having a large number of holes) 48 A gap between a plurality of 40 changed by movement of the moving means 44. This gap change changes the pressure and flow pattern, and changes the microbubble size distribution and microbubble concentration.
50 In-cylinder curved surface 52 (50 and / or) which is a collision member that changes the liquid flow direction to a substantially right angle again by colliding with a jet-like discharge liquid discharged from a flow guide path 51 that changes the liquid flow direction to a substantially right angle. ) The flow direction vector 54 after the jet-like discharge liquid discharged from 50 by the moving means 5351 for moving the position 51 again changes the liquid flow direction to a substantially right angle again. The discharge direction vector 54 shown in FIG. Flow vector 56 of the jet-like discharge liquid discharged from the nozzle 5550 from which the collision member (cylindrical body having a curved surface inside the cylinder) has been removed. In the nozzle shown in FIG. Nozzle 57 with 50 parts removed. Vector 60 of liquid flow in which gas is supersaturated at high pressure on the downstream side of pressurizing means 40. Occluded circular surface of the busy been pail-shaped cylindrical body 61 60 (bottom surface of the pail)
62 60 Open circular surface 63 Cylindrical body 64 in which a flow obstacle 64 is further arranged on a part of the open circular surface 62 of 60.

Claims (2)

In a microbubble generator using the pressure dissolution (pressurization / depressurization) method, in which gas is supersaturated and mixed in liquid at high pressure and then stimulated to appear as microbubbles and ejected by liquid ejection means.
Means for stimulating the supersaturated gas included in the generator to form microbubbles,
A flow guiding path that is disposed inside the liquid ejecting means and changes a liquid flow direction substantially at right angles; and
A collision member disposed at a discharge portion of the liquid discharge means, which collides with a jet-like liquid discharged from the guide path and changes the liquid flow direction to a substantially right angle again;
Moving means for moving the position of the flow guiding path so that a substantially right-angle change in the liquid flow direction is not made, and / or
Moving means for moving the position of the impingement member so that the liquid flow direction is not substantially perpendicularly changed;
A microbubble generator having a variable particle size distribution and concentration, wherein the microbubble particle size distribution and the microbubble concentration are adjusted by a change in liquid flow caused by the movement of the moving means. A change method (scale-up / scale-down) of a microbubble generator using the microbubble generator having variable particle size distribution and concentration according to claim 1 ,
In a plurality of microbubble generators with different bubble generation methods and / or a plurality of microbubble generators with different input energy limits (device capacities) in the same bubble generation method,
A first step of preparing a database of particle size distribution of microbubbles and concentration range of microbubbles generated by the plurality of microbubble generators;
A second step of extracting the particle size distribution of the microbubbles and the concentration range of the microbubbles, which can obtain an influence on a desired organism or non-living object, using the microbubble generator having variable particle size distribution and concentration according to claim 1. ,
The particle size distribution of the microbubbles and the concentration range of the microbubbles obtained in the second step and having an effect on the desired organism or non-organism, and
A third step of extracting a particle size distribution of microbubbles and a concentration range of the microbubbles which are generated by the plurality of microbubble generators of the database prepared in the first step,
Depending on the type of microbubbles, different bubble generation methods and / or microbubble generation devices with different input energy limits (device capacities) in the same bubble generation method can be expected to have an effect on a desired organism or non-living matter. A method of changing (scaling up / down) a bubble generator.