JP5039338B2 - Chemical solution for piezo nebulizer - Google Patents

Description

  The present invention relates to a chemical solution for a piezo nebulizer that exhibits excellent diffusibility and pest control effect without using a heating device or a blower.

  Conventionally, as a method for controlling a pest by evaporating a pest control agent, a method of heating and evaporating a chemical solution or a mat containing the pest control agent, a pest control agent held by a carrier by an air flow generated by rotation of a fan. A method of transpiration is known. In these transpiration systems, in particular, studies have been made on pharmaceutical compositions for obtaining good transpiration. For example, a pesticide composition for a liquid absorbent core in which a compound such as 3,5-di-t-butyl-4-hydroxytoluene is blended in an organic solvent solution of an insecticide (for example, see Patent Document 1). Are known.

On the other hand, in addition to the transpiration system, a method of transpiration of a drug using a piezo nebulizer is known. In this method, ultrasonic waves generated by an ultrasonic oscillator are transmitted to a liquid absorption device through a vibrator, and the chemical liquid absorbed by the liquid absorption device is evaporated (see, for example, Patent Document 2). Patent Document 2 shows that a liquid fragrance and an insecticide can be applied to a piezo-type sprayer, but no specific pharmaceutical composition or effect is described.
JP-A-60-161902 (page 1-9) JP-A-8-215308 (page 1-4)

In a piezo-type sprayer, a blower is used to obtain drug diffusibility. This is trying to achieve the desired effect by increasing the diffusibility of the drug, but it consumes more power and lacks sustainability to drive with only the battery, and it is difficult to miniaturize the entire nebulizer. .
Therefore, the present inventors have come up with the idea that using a drug composition that provides drug diffusibility without using a blower can reduce power consumption, can be driven by a battery, and can be downsized.
This invention is providing the chemical | medical solution for piezo-type nebulizers which exhibits the outstanding diffusibility and pest control effect, without using an air blower.

  As a result of diligent investigations to solve the above problems, the present inventors have demonstrated high volatility and diffusibility when vaporized with a piezo nebulizer using a chemical solution that combines a specific pest control agent and an organic solvent. As a result, the present inventors have found that an excellent pest control effect is exhibited and have completed the present invention.

That is, the medicine for a piezo nebulizer according to the present invention is characterized by containing (1) transfluthrin or methofluthrin having the following constitution and isoparaffin, silicone oil or glycol ether having a boiling point of 150 to 250 ° C. A chemical solution for a piezo-type sprayer.
(2) The chemical solution for a piezo-type sprayer according to (1), which is a chemical solution for controlling Culex pipiens .
(3) Fill the container having a liquid absorption core with the chemical liquid for the piezo type sprayer according to (1) or (2), set the piezo type sprayer, and store the chemical liquid absorbed in the liquid absorption core. A pest control method that controls the pests by transpiration.

  The chemical solution for a piezo-type sprayer according to the present invention can exhibit an excellent pest control effect by diffusing a drug over a wide range without using a heating device or a blower. In addition, since the piezo-type sprayer can be driven with less electric power because no blower is used, the battery can be used as a power source, and pests can be controlled indoors and outdoors, in the vehicle, etc. by being miniaturized and carried.

The pest control agent of the present invention is a pest control agent having a vapor pressure of 1 × 10 ⁻⁵ mmHg or more at 25 ° C. Dinotefuran, hydroprene, metoprene and the like can be mentioned, and one or more of these can be mixed and used. Among these, transfluthrin having a vapor pressure of 2.6 × 10 ⁻⁵ mmHg at 25 ° C., metfurthrin having a vapor pressure of 1.4 × 10 ⁻⁵ mmHg at 25 ° C., vapor pressure at 25 ° C. Is preferably 7.7 × 10 ⁻⁵ mmHg when applied to a piezo nebulizer because of its good transpiration, excellent pest control effect, and good solubility in the organic solvent of the present invention.

  As the organic solvent, an organic solvent having a boiling point of 150 to 250 ° C. (including an amphiphilic solvent), for example, paraffin such as normal paraffin, isoparaffin, naphthene, and a mixture thereof, decamethylcyclopentasiloxane, etc. Examples include silicone oil and glycol ethers such as butylpropylene glycol. Specifically, the boiling point is a boiling point at 1 atm. For example, the trade name “Marcazole” (manufactured by Maruzen Petroleum Co., Ltd.), the trade name “Neothiozole” (manufactured by Chuo Kasei Co., Ltd.), the trade name “liquid paraffin 40S” (Manufactured by Chuo Kasei Co., Ltd.), trade name “SH344” (manufactured by Toray Silicon Co., Ltd.), trade name “BFG” (manufactured by Nippon Emulsifier Co., Ltd.), etc., and these may be used alone or in combination. it can. Among these, paraffin is preferable because it can stably maintain the transpiration of the pest control agent and there is no unpleasant odor. Moreover, as long as it is practicable, it may contain water.

  The chemical solution for a piezo nebulizer according to the present invention (hereinafter also referred to as “chemical solution”) contains at least a pest control agent having a specific vapor pressure as described above and an organic solvent having a specific boiling point. As a result, these combine to exhibit high volatility and diffusibility, and to exhibit an excellent pest control effect. In contrast, a chemical solution containing only one of them cannot achieve both volatility and diffusibility.

The chemical | medical solution of this invention is obtained by dissolving said pest control agent in said organic solvent so that it may become 1-20 weight%, Preferably 2-10 weight%.
Further, the chemical solution of the present invention may contain a fragrance, a deodorant, a bactericide, a pigment, a stabilizer, a volatilization regulator, a preservative, an antioxidant, etc. as necessary as long as the effects of the invention are exhibited. it can.

  What is necessary is just to fill the chemical | medical solution of this invention into the suitable container provided with the liquid absorption (liquid absorption core), and to set and use it for a piezo type sprayer. Thereby, the ultrasonic wave generated by the ultrasonic oscillator is transmitted to the liquid absorption core via the vibrator, and the chemical liquid absorbed by the liquid absorption core can be evaporated.

  As the piezo type sprayer for evaporating the chemical solution of the present invention, for example, a piezo type sprayer as shown in FIG. 1 can be used. As shown in the figure, this piezo-type sprayer includes a container 1 containing a chemical liquid 2, a liquid absorbent core 3 whose upper part protrudes from the upper opening of the container 1 and whose lower part is immersed in the chemical liquid 2 in the container 1, An ultrasonic vibrator 5 in contact with the upper end of the liquid absorbent core 3 and an ultrasonic oscillator 7 connected to the vibrator 5 are provided. A joining piece 6 made of metal, ceramic or the like is disposed between the upper end portion of the liquid absorbent core 3 and the vibrator 5, whereby the vibrator 5 is indirectly attached to the liquid absorbent core 3 (via the joint piece 6). ) Touching. Reference numeral 8 denotes a battery as a power source. The liquid absorbent core 3 is supported by a hollow disk type core support 4 fitted in the upper opening of the container 1.

  The absorbent core 3 is made of a material having a large surface tension, such as felt, sponge, cotton, or a porous material (for example, a molded body mainly composed of carbonaceous fine powder and made of a mixture of this and a binder). The core material formed in the above can be used. Among these, the molded body using the carbonaceous fine powder exhibits a liquid absorbing function only when an ultrasonic wave is applied, and functions as a plug when no voltage is applied.

  In a state where the chemical liquid 2 is sufficiently absorbed to the upper end of the liquid absorbent core 3 as described above, a signal is sent from the oscillator 7 to the vibrator 5 to vibrate the vibrator 5 and the joining piece 6 ultrasonically. As a result, ultrasonic vibration energy equal to or higher than the surface tension of the chemical liquid 2 and higher than the viscosity is applied to the upper end portion of the liquid absorbent core 3, and the chemical liquid 2 is atomized into the air as fine droplets from the liquid absorbent core 3. Can be evaporated. In the piezo-type sprayer, the vibrator 5 may be in direct contact with the upper end portion of the liquid absorbent core 3 without arranging the joining piece 6.

  Further, as a piezo type sprayer for evaporating the chemical solution of the present invention, the piezo type sprayer shown in FIG. 2 as described in US Pat. No. 6,450,419 B1 can also be used. As shown in the figure, this piezo-type sprayer includes a container 1 containing a chemical liquid 2, a liquid absorbent core 3 whose upper part protrudes from the upper opening of the container 1 and whose lower part is immersed in the chemical liquid 2 in the container 1, An ultrasonic vibrator 10 that is in contact with the upper end of the liquid absorbent core 3, a lid 11 that is fixed to the vibrator 10 and is fitted into the upper opening of the container 1, and an ultrasonic oscillator that is connected to the vibrator 10. (Not shown).

  The absorbent core 3 is supported by a hollow disk-shaped core support 4 fitted in the upper opening of the container 1, and the vibrator 10 is fixed to the lid portion 11 by the claw portion 12 and the fixing member 13 of the lid portion 11. Has been. The vibrator 10 has a diameter of 5 to 10 mm at the center. A joining piece 15 is disposed between the upper end portion of the liquid absorbent core 3 and the vibrator 10, whereby the vibrator 10 is in contact with the liquid absorbent core 3 indirectly (via the joint piece 15). As the joining piece 15, an orifice plate having a diameter of 3 to 20 μm at the center is used.

The lid 11 is provided with a spray port 14, and a signal is sent from the oscillator to the vibrator 10 in a state where the chemical liquid 2 is sufficiently absorbed by the upper end of the liquid absorbent core 3, and the vibrator 10 is When ultrasonically vibrated, the chemical liquid 2 can be atomized into the air as fine droplets from the spray port 14 and evaporated.
Although the vibrator 5 having a predetermined diameter at the center has been described, a vibrator having a large number of holes on the entire surface may be used instead.

The piezo-type sprayer is preferably provided with one or more of the following conditions, more preferably a sprayer provided with all.
(1) Do not use a blower.
(2) The frequency of the ultrasonic oscillator is 50 to 300 kHz.
(3) Intermittent transpiration in which driving for 5 milliseconds to 1 second and stopping for 1 to 180 seconds are alternately performed per time can be performed.
(4) The amount of the chemical solution that is evaporated by one driving is 0.01 to 1 μL.
(5) Power consumption in one driving is 0.3 to 10 W.
(6) It can be driven by the following battery.
Alkaline batteries: LR20 (single 1), LR14 (single 2), LR6 (single 3), LR3 (single 4),
LR1 (single 5)
Manganese batteries: R20P (single 1), R14P (single 2), R6P (single 3), R3P (single 4),
R1P (AA)

  EXAMPLES The present invention will be described in more detail with reference to examples below, but the present invention is not limited to these examples.

  The chemical solution of the present invention is evaporated by a piezo-type sprayer as shown in FIG. 1 without using a blower, and the knockdown (upside down) rate, etc. with respect to the test insect is examined, and the diffusibility and the pest control effect of the chemical solution are confirmed. .

<Adjustment of chemical solution>
(1) Example 1
A chemical solution in which transfluthrin is dissolved in isoparaffin having a boiling point of 178 to 181 ° C. (trade name “Marcazole” manufactured by Maruzen Petroleum Co., Ltd.) to 4% by weight.
(2) Example 2
A medicinal solution in which metfurthrin is dissolved in isoparaffin having a boiling point of 178 to 181 ° C. (trade name “Marcazole” manufactured by Maruzen Petroleum) to 4% by weight.
(3) Comparative Example 1
A chemical solution obtained by dissolving praretrin so as to be 4% by weight in isoparaffin having a boiling point of 178 to 181 ° C. (trade name “Marcazole” manufactured by Maruzen Petroleum).

<Driving conditions for piezo sprayer>
The piezo-type sprayer in this example was used under the driving conditions shown below without using a blower.
・ Frequency of ultrasonic oscillator: 150 kHz
・ Driving condition: Intermittent driving that drives for 10 msec and stops for 8 sec. ・ Amount of chemical solution: 0.05 μL of transpiration by one driving
・ Power consumption: 10W during oscillation
・ Battery: One LR6 (AA) (1.5V)

<Test Example 1>
As shown in FIG. 3, a metal cage (16 mesh) containing test insects (15 adult female mosquitoes) is placed from the ceiling so that the height from the floor is 75 cm and 150 cm in a 6-tatami room. It was hung at two corners. Then, a piezo-type sprayer was installed in the center of the floor of the living room, a container equipped with a liquid absorbing solution containing 10 mL of chemical solution was set, and transpiration was started under the above test conditions. 60 minutes after the start, the number of test insects knocked down in the cage was counted to determine the knockdown rate (%).
The test results are shown in Table 1. As shown in Table 1, Example 1 of the present invention has a high knockdown rate in each cage, and has been demonstrated to be excellent in diffusibility and pest control effect.

<Test Example 2>
The test was performed in the same manner as in Test Example 1 except that Example 1 was replaced with Example 2. Then, after the start of transpiration, the time until half of the test insects were knocked down was measured to determine the half knockdown time (minutes).
The test results are shown in Table 2. As shown in Table 2, Example 2 of the present invention demonstrated that the half-knockdown time in each cage was fast, and was excellent in diffusibility and pest control effect. In Comparative Example 1, the number of test insects knocked down within 120 minutes did not reach half.

<Discussion>
Table 3 shows the half-lethal dose (μg / head) of the insect pest control squid used in the chemical solution. Although transfluthrin used in Example 1 had a half-lethal dose equivalent to or higher than that of praretrin used in Comparative Example 1, in Test Example 1, 60 minutes later The knockdown rate in Example 1 was 100% compared to 0-30% in Comparative Example 1. In addition, the half-lethal dose of methfluthrin used in Example 2 is smaller than that of praretrin used in Comparative Example 1, but the half-knockdown time (minutes) in Comparative Example 1 is higher than that in Comparative Example 1. The result was 2 to 4 times faster.
From the consideration of the above combined results of Test Examples 1 and 2, it was found that the chemical solution of the present invention is suitable for use in a piezo nebulizer.

<Test Example 3>
In Test Example 3, a test for examining the transpiration amount of the organic solvent was performed. The organic solvents used in Test Example 3 are as shown below.
Paraffin 1: Isoparaffin (trade name “Marcazole” manufactured by Maruzen Petroleum Corporation)
Paraffin 2: Normal paraffin (trade name “Neothiozole” manufactured by Chuo Kasei Co., Ltd.)
Paraffin 3: Isoparaffin / naphthene mixture (trade name “liquid paraffin 40S” manufactured by Chuo Kasei Co., Ltd.)
Silicone oil: Decamethylcyclopentasiloxane (trade name “SH344” manufactured by Toray Silicon Co., Ltd.)
Glycol ether: butyl propylene glycol (trade name “BFG” manufactured by Nippon Emulsifier Co., Ltd.)
Table 4 shows the boiling points and transpiration amounts of these solvents.
Methofluthrin was dissolved in these solvents, and each solution was adjusted to 4% by weight to prepare medicinal solutions. 10 mL of each of these chemical solutions was put into a container equipped with a liquid absorption wick and evaporated using a piezo-type sprayer. The amount of transpiration of the chemical solution was determined as an average transpiration amount of 0 to 300 hours by measuring the amount of decrease in the bottle weight every predetermined time. The driving conditions of the piezo nebulizer were the same as in Test Example 1.

The results of Test Example 3 are shown in Table 4. As shown in Table 4, it was shown that when an organic solvent having a boiling point of 165 to 250 ° C was used, the average transpiration amount was 3 to 5 times that of an organic solvent having a boiling point of 270 to 360 ° C. From this, it was found that if an organic solvent having a boiling point of about 150 to 250 ° C. is used, it is energy efficient to evaporate the drug and is suitable for use in a piezo nebulizer.

<Test Example 4>
In Test Example 4, a test for examining the boiling point of the organic solvent was performed. The chemical solution used in Test Example 4, the piezo nebulizer and its driving conditions, and the test conditions are as shown below.
<Adjustment of chemical solution>
(1) Example 3
A chemical solution in which transfluthrin is dissolved in isoparaffin having a boiling point of 178 to 181 ° C. (trade name “Marcazole” manufactured by Maruzen Petroleum Co., Ltd.) to 5.6% by weight.
(2) Comparative Example 2
A chemical solution in which transfluthrin is dissolved in liquid paraffin having a boiling point of 270 to 360 ° C. (trade name “liquid paraffin 40S”, manufactured by Chuo Kasei Co., Ltd.) to 5.6% by weight.

<Piezo type sprayer and its driving conditions>
An apparatus as shown in FIG. 2 was used as a piezo type sprayer. This piezo-type sprayer includes a vibrator 10 having a diameter of 8.5 mm at the center and an orifice plate having a diameter of 6 μm at the center as the joining piece 15. The driving conditions of this piezo-type sprayer were the same as in Test Example 1.

<Test conditions>
As shown in FIG. 3, metal cages 30 and 30 (16 mesh) containing test insects (15 adult female mosquitoes) so that the height from the floor is 75 cm and 150 cm in a 6-tatami room. It was hung from the ceiling at two locations diagonally. And the container provided with the liquid absorption which contained 10 mL of chemical | medical solutions in the piezo type sprayer installed in the predetermined position was set, and transpiration was started on the said test conditions. 60 minutes after the start, the number of test insects knocked down in the cage was counted to determine the knockdown rate (%).

The positions and number of the piezo-type sprayers installed in Example 3 and Comparative Example 2 are as follows.
Example 3: 1 unit in the center of the floor of a 6-tatami room Comparative Example 2: 3 units in the center of the floor of the same room

The test results are shown in Table 5. As shown in Table 5, Example 3 of the present invention has a high knockdown rate in each cage, and was proved to be excellent in diffusibility and pest control effect. On the other hand, although the comparative example 2 installed the piezo-type sprayer 3 times as much as Example 3, the knockdown rate was low and the diffusibility was inferior at a height of 150 cm from the floor surface.

<Test Example 5>
In Test Example 5, a test was conducted to examine the volatilization amount depending on the content of the pest control agent. The chemical solution used in Test Example 5 is as shown below.
<Adjustment of chemical solution>
(1) Example 4
A chemical solution in which transfluthrin is dissolved in isoparaffin having a boiling point of 178 to 181 ° C. (trade name “Marcazole” manufactured by Maruzen Petroleum Co., Ltd.) so as to be 5.3% by weight.
(2) Example 5
A chemical solution in which transfluthrin is dissolved in 2.3% by weight in isoparaffin having a boiling point of 178 to 181 ° C. (trade name “Marcazole” manufactured by Maruzen Petroleum Corporation).
(3) Example 6
A medicinal solution in which metfurthrin is dissolved in isoparaffin having a boiling point of 178 to 181 ° C. (trade name “Marcazole” manufactured by Maruzen Petroleum Co., Ltd.) to 1.2% by weight.
(4) Example 7
A chemical solution obtained by dissolving Metofluthrin to 1.7% by weight in isoparaffin having a boiling point of 178 to 181 ° C. (trade name “Marcazole” manufactured by Maruzen Petroleum Co., Ltd.).
(5) Example 8
A drug solution in which metfurthrin is dissolved to 2.3% by weight in isoparaffin having a boiling point of 178 to 181 ° C. (trade name “Marcazole” manufactured by Maruzen Petroleum Corporation).

10 ml of each of the chemical solutions obtained above was put into a container equipped with a liquid absorption core and evaporated with a piezo nebulizer, and the volatilization amount of the active ingredient was measured over 0 to 12 hours. The piezo nebulizer and its driving conditions were the same as in Test Example 4. In addition, it evaluated similarly about the chemical | medical solution of the said Example 3. FIG.
The results of Test Example 5 are shown in Tables 6 and 7. As shown in Tables 6 and 7, the chemical solution having a higher content of the pest control agent showed a larger amount of transpiration.

  As mentioned above, although one Embodiment of this invention was shown, it cannot be overemphasized that this invention is applicable to what was changed and improved in the range which does not deviate from the summary of this invention, without being limited to Embodiment mentioned above. For example, the piezo type sprayer is optional as long as the chemical solution according to the present invention can be implemented. In the above embodiment, the chemical solution used in the piezo type sprayer shown in FIG. 1 is used in the piezo type sprayer shown in FIG. The same effect can be obtained. Moreover, the same effect is acquired even if the chemical | medical solution evaporated in the 6-tatami room in the above-mentioned test example is evaporated in the 12-mat room.

It is a schematic sectional drawing which shows an example of the piezo type sprayer in this invention. It is a schematic sectional drawing which shows the piezo type sprayer used in the Example. It is a schematic explanatory drawing which shows the test method in an Example.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Container 2 Chemical solution 3 Liquid absorption core 4 Core support body 5 Ultrasonic vibrator 6 Joining piece 7 Ultrasonic oscillator 8 Battery

Claims (3)

A chemical solution for a piezo type nebulizer, characterized by containing transfluthrin or metfurflurin and isoparaffin, silicone oil or glycol ether having a boiling point of 150 to 250 ° C. The chemical solution for a piezo-type sprayer according to claim 1 , which is a chemical solution for controlling squid squid . The chemical solution for a piezo type sprayer according to claim 1 or 2 is filled in a container equipped with a liquid absorption core, set in the piezo type sprayer, and the chemical liquid absorbed in the liquid absorption core is evaporated to control pests. Pest control method to do.

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