JP5009701B2 - Underwear for patients with atopic dermatitis - Google Patents

Description

The present invention relates to an atopic dermatitis patient's underwear that can be used safely even when a patient with atopic dermatitis wears it for a long period of time.

In recent years, an increase in the number of patients with atopic dermatitis has become remarkable and has become a social phenomenon. There are many unclear points in the pathogenesis of such atopic dermatitis, and a treatment method has not yet been established.

When there is a disease such as atopic dermatitis, since the skin is in a very sensitive state, the safety of an underwear that is in direct contact with the skin for a long time is extremely important. In particular, pruritus in atopic dermatitis is remarkable, and if it is scratched, the symptoms worsen and further itching leads to a vicious circle. Therefore, the underwear worn by patients with atopic dermatitis should have a low burden on the skin. It is said.
In general, patients with atopic dermatitis generally wear cotton underwear, but cotton underwear causes symptoms worsening such as increased itchiness and enlarged affected areas when worn for a long time. There was a thing. In particular, this tendency was remarkable in infants because of their sensitive skin.

On the other hand, Patent Document 1 discloses an anti-atopic fiber structure in which glycyrrhizic acid or the like is fixed to the fiber surface. Patent Document 2 discloses an undergarment that uses long fibers made of a specific ethylene-vinyl alcohol copolymer and has a coefficient of variation in mental sweat displacement within a predetermined range. However, in the underwear described in Patent Documents 1 and 2, skin irritation reduction and symptom suppression effects for patients with atopic dermatitis have not been sufficiently verified, and skin irritation and symptoms of atopic dermatitis patients are not fully verified. Inhibition or the like was not sufficiently achieved.
Japanese Patent Laid-Open No. 10-131043 JP 2004263331 A

In view of the above situation, the present invention is atopic dermatitis that is less likely to cause discomfort and worsening of symptoms even when a patient with atopic dermatitis wears for a long time and can be used safely. The object is to provide patient underwear.

The present invention is an underwear for atopic dermatitis patients having fibers made of a thermoplastic elastomer having a bending resistance of 1 to 10 cN measured by a method according to JIS L 1018, and immersed in water for 1 hour. After dehydration for 5 minutes, when left in an atmosphere of 20 ° C. and 65% RH, the time until the moisture content reaches 5% is 60 minutes or less, and the water absorption rate measured by the method according to JIS L 1907 is 5 It is an underwear for atopic dermatitis patients having a diffusion diameter of 1.8 to 6.0 cm after lapse of 1 minute after adding 100 μL of ˜15 cm or 2 g / L benzoperpurine aqueous solution.
The present invention is described in detail below.

The underwear for atopic dermatitis patients of the present invention has fibers made of a thermoplastic elastomer. Since the fiber made of the thermoplastic elastomer has high flexibility and water absorption, an underwear having an excellent texture and touch can be obtained while giving a refreshing feeling.

Although it does not specifically limit as said thermoplastic elastomer, A polyamide-type elastomer and / or a polyester-type elastomer are suitable.

The polyamide-based elastomer is not particularly limited, and examples thereof include a polyether block amide copolymer, a polyether amide copolymer, and a polyester amide copolymer. These may be used independently and 2 or more types may be used together.
Among these polyamide-based elastomers that are commercially available, for example, Pebax (manufactured by Arkema), UBE nylon (manufactured by Ube Industries), Grilon ELX, Grillamide ELY (above, manufactured by MMS Showa Denko), Daiamide, Bestamide (above, manufactured by Daicel Dexa Corporation) and the like can be mentioned.

It does not specifically limit as said polyester-type elastomer, For example, a polyetherester copolymer, a polyesterester copolymer, etc. are mentioned. These may be used independently and 2 or more types may be used together.
Among these polyester elastomers that are commercially available, for example, Gleasing (Dainippon Ink Chemical Co., Ltd., Nouvelan (Teijin Chemicals), Perprene (Toyobo), Hytrel (Toray DuPont) Product), Primalloy (manufactured by Mitsubishi Chemical Corporation), and the like.

Among these thermoplastic elastomers, the polyether block amide copolymer represented by the following formula (1) is excellent in spinnability and provides an underwear having high flexibility, water absorption and moisture diffusibility. Particularly preferred. Examples of such polyether block amide copolymers that are commercially available include Pebax (manufactured by Arkema).

In formula (1), PA represents polyamide and PE represents polyether.

The preferable lower limit of the single yarn fineness of the fiber made of the thermoplastic elastomer is 0.5 dtex, and the preferable upper limit is 5 dtex. Moreover, the preferable minimum of a total fineness is 20 dtex, and a preferable upper limit is 150 dtex. By setting the single yarn fineness and the total fineness within the above ranges, the effects of the present invention can be realized more favorably.

The resin component contained in the fiber used in the underwear for patients with atopic dermatitis of the present invention may be the above thermoplastic elastomer alone, but the fiber consisting only of the thermoplastic elastomer as the resin component is generally sticky. And spinning may be difficult, and may be used in combination with other resins than the thermoplastic elastomer.

When the resin component contained in the fiber used in the underwear for atopic dermatitis patients of the present invention is composed of the thermoplastic elastomer and another resin, a mixture of these resins may be spun. It may have a core-sheath structure in which the resin containing the thermoplastic elastomer covers the surroundings of the fibers, covering, and the like.
The other resin is not particularly limited. For example, in the case of mixing and spinning, a polyamide-based resin such as nylon 12, etc .; in the case of a core-sheath structure, nylon 6, polyester, cotton, rayon, etc. Can be mentioned.

Further, the underwear for patients with atopic dermatitis of the present invention may be formed by knitting only fibers made of the above thermoplastic elastomer, but is necessary for the underwear such as the touch within the range not impairing the object of the present invention. May be knitted with other fibers to improve requirements. Examples of such other fibers include, but are not limited to, polyamide resins such as cotton, nylon 6, and nylon 12; polyester, rayon, and the like.

When the fiber made of the thermoplastic elastomer and other fibers are knitted, the preferred lower limit of the ratio of the fiber made of the thermoplastic elastomer is 5% by weight. If it is less than 5% by weight, the effects of the present invention may not be achieved.

The underwear for patients with atopic dermatitis of the present invention has a lower limit of the bending resistance measured by a method according to JIS L 1018 of 1 cN and an upper limit of 10 cN. If it is less than 1 cN, the texture of the underwear becomes too soft, clings to the skin, and worsens the symptoms of atopic dermatitis. When it exceeds 10 cN, the texture of the underwear becomes too hard, the affected part of atopic dermatitis is stimulated, and the burden on the skin increases. The bending resistance is measured in accordance with JIS L1018 8.22.5 E method (handle ohmmeter method).

Moreover, the underwear for patients with atopic dermatitis of the present invention has a lower limit of bending resistance of 5 cN and an upper limit of 30 cN measured by a method based on JIS L 1018 after washing 10 times. Although the cotton underwear is characterized by being easily hardened after washing, the underwear for atopic dermatitis patients of the present invention has high flexibility even after washing. In addition, the said washing is performed by the method based on JISL0844.

The underwear for patients with atopic dermatitis of the present invention is immersed in water for 1 hour, dehydrated for 5 minutes, and then left in an atmosphere of 20 ° C. and 65% RH until the moisture content reaches 5% (hereinafter referred to as “underwater”) , Simply referred to as drying time) is 60 minutes. When it exceeds 60 minutes, when it is worn for a long time, it becomes sticky or feels bad, and discomfort for atopic dermatitis patients increases. A preferred upper limit is 50 minutes.
The drying time is determined by cutting the dough into a predetermined size, immersing the dough in water for 1 hour, dehydrating using a dehydrator for 5 minutes, and then leaving it in an atmosphere of 20 ° C. and 65% RH. It can be determined by measuring the time until the moisture content reaches 5%. The dehydration is performed at 1700 rpm using a round meter dehydrator (LM-12D manufactured by Suga Test Instruments Co., Ltd.).

The underwear for patients with atopic dermatitis of the present invention has a water absorption rate of 5 to 15 cm measured by a method according to JIS L 1907, or 100 μL of a 2 g / L benzoperpurine aqueous solution, and a diffusion diameter after 1 minute has passed. Is 1.8 to 6.0 cm.
The underwear for atopic dermatitis patients of the present invention can reduce the burden on the affected area by satisfying the water absorption speed or diffusion diameter in the above-described range, thereby suppressing the stuffiness caused by sweat or the like.

The underwear for patients with atopic dermatitis of the present invention has a lower limit of water absorption rate of 5 cm and an upper limit of 15 cm as measured by a method according to JIS L 1907. If the distance is less than 5 cm, the water absorption is poor, so that sweating or the like causes stuffiness and the burden on the affected area increases. If the distance exceeds 15 cm, the burden on the affected area increases by taking more water than necessary. In addition, the said water absorption speed shall be measured according to the Pyreck method of JISL1907.

The underwear for patients with atopic dermatitis of the present invention has a lower limit of the diffusion diameter of 1.8 cm and an upper limit of 6.0 cm after 100 μL of a 2 g / L benzoperpurine aqueous solution is dropped. If the distance is less than 1.8 cm, the diffusibility is poor, so sweating or the like causes stuffiness and the burden on the affected area increases, and if it exceeds 6.0 cm, more moisture is taken away than necessary, resulting in a burden on the affected area. growing. A preferred lower limit is 2.5 cm and a preferred upper limit is 5.0 cm. The diffusion diameter is determined by suspending 100 μL of a benzoperpurine aqueous solution from the top of a test piece of a predetermined size, leaving it for 1 minute, and then leaving it for another 3 minutes. It can be determined by measuring the length.

Although it does not specifically limit as a method of manufacturing the underwear for atopic dermatitis patients of this invention, For example, the raw yarn which consists of thermoplastic elastomers is produced by performing melt spinning using the resin pellet which consists of thermoplastic elastomers. . Next, by using the obtained raw yarn and knitting with natural fibers such as cotton and synthetic fibers such as polyester, a method for producing an underwear for patients with atopic dermatitis can be used.

According to the present invention, even when a patient with atopic dermatitis wears for a long time, the discomfort of the affected area and the deterioration of symptoms are unlikely to occur, and the underwear for patients with atopic dermatitis can be used safely. Can be provided.

Hereinafter, the present invention will be described in more detail with reference to examples. However, the present invention is not limited to these examples.

(Implementation group)
Using resin pellets made of a polyether block amide copolymer ("Pebax 1041SA01" manufactured by Arkema Co., Ltd.), which is a thermoplastic polyamide-based elastomer, yarn was produced by a melt spinning method to obtain an original yarn having a fineness of 80 dtex.
Next, fibers (80 dtex / 34 filaments) using the raw yarn made of polyether block amide copolymer are placed on the skin side, cotton (60th single yarn) is placed on the outside, and reversible with a milling machine. A knitted fabric having a structure was knitted, and an undergarment was produced using the knitted fabric. In addition, the composition of the obtained underwear was 42% for fibers using raw yarn made of a polyether block amide copolymer and 58% for cotton.

(Control group)
An underwear made of 100% cotton (60th single yarn) was produced.

(Evaluation)
The following evaluation was performed about the underwear obtained in the implementation group and the control group.

(1) Flexibility According to JIS L 1018 8.22.5 E method (handle ohmmeter method), set the vertical direction of a 20 cm x 20 cm test piece on a 20 mm wide slit so that it is perpendicular to the slit. The blade of the penetrator was lowered by 8 mm at a position of 6.7 cm (1/3 of the test width) from the test piece, and the resistance value at this time was evaluated as an average value of n = 3.
Further, in accordance with JIS L0844, the bending resistance after 10 washings was measured in the same manner.

(2) Water absorption According to the “Pyrek method” of JIS L 1907, the lower end of a 200 mm × 25 mm test piece was adjusted to be immersed in water, and the rising height of water after standing for 10 minutes was measured. Measurement was performed in each of the vertical and horizontal directions (n = 5), and the average value was calculated.

(3) A test piece having a diffusibility of 10 cm × 5 cm is placed on an acrylic plate (11.5 cm × 6.2 cm, weight 28 g) having a fluororesin sheet attached to the surface, and 2 g from the top. An acrylic plate (11.5 cm × 6.2 cm, weight 28 g) having a fluororesin sheet attached to the surface is suspended on the fluororesin sheet side after 100 μL of / L benzoperpurine aqueous solution is dropped and left for 1 minute. It was placed in contact with the dough and left for another 3 minutes. After standing for 3 minutes, the maximum length and the minimum length of the portion dyed with the benzoperpurine aqueous solution were measured.

(4) After the dough cut into quick-drying vertical 10 × horizontal 20 cm was immersed in water for 1 hour, it was dehydrated at a rotation speed of 1700 rpm for 5 minutes using a round meter dehydrator (LM-12D manufactured by Suga Test Instruments Co., Ltd.). The dehydrated dough was hung and allowed to stand at 20 ° C. and 65% RH, and the time until the moisture content of the dough reached 5% was measured. The moisture content of the dough represents the ratio of the weight of water to the weight of the dough at the time of drying.

(5) Moisture permeability According to “A-2 water method” of JIS L 1099 (moisture permeability test method for textile products), moisture permeability is measured using a heat retention tester (YAMAGUCHI SCIENCE IND.CO., LTD). did.

(6) Wear test The following evaluation was performed after wearing the underwear of an implementation group and a comparison group to the child atopic dermatitis patient of sex, age, height, and weight shown in Table 1, respectively. Each evaluation was performed twice before wearing and twice after wearing (after 2 weeks and after 4 weeks), and the average value and standard deviation before and after wearing were calculated.
Moreover, about the average value after wearing, the p value within each group and between both groups was computed, and the statistical test using the t test was performed. All tests were performed by a two-sided test. When p <0.05, it was judged that there was a statistically significant difference.

(6-1) SCORAD (Scoring atomic dermatitis)
Evaluation of the severity of atopic dermatitis was evaluated based on the regulations of SCORAD. Evaluation was performed on the whole body and the underwear part.
SCORAD scored the extent of skin examination, the importance of each skin examination (erythema, edema / papules, exudation / scab, lichenification, scratching scar, dry skin), subjective symptoms (itchiness, insomnia) The determination of the range and importance of the skin examination was performed by a doctor, and the subjective symptoms were determined by the parent of the patient.

(6-2) Measurement of keratin water content (SCH)
The stratum corneum water content at the location (1) shown in FIG. 1 was measured using Corneometer CM820 (Courage and Kazaka). In addition, the measurement of the amount of keratin moisture was performed 5 times, and the average value was made into the measured value.

(6-3) Measurement of moisture transpiration (TEWL)
The amount of water transpiration at the location (1) shown in FIG. 1 was measured using a Tewmeter TM300 (Courage and Khazaka). The amount of water transpiration was measured 5 times, and the average value was taken as the measured value.

(6-4) Measurement of growth hormone Night urine was collected at the time of waking up, and as a reagent kit, Hitazyme CL GH-U (distributor: Kainos Co., Ltd., manufacturer: Hitachi) by the CLEIA method (chemical issuance and enzyme immunoassay) The growth hormone was measured by using Lumino meter MM-200 (manufactured by Corona Electric Co., Ltd.) as a measuring instrument. Urine was stored frozen and all analyzes were performed in the same laboratory. For the analysis, a creatinine correction value (pg / mg / Cr) was used.

(6-5) Measurement of Cortisol and s-IgA Cortisol and s-IgA were measured by collecting saliva by a method including absorbent cotton in the mouth and by the following method. Before the measurement, the mouth was washed and the measurement time was unified to 1 minute 30 seconds. In addition, due to daily fluctuations, the measurement time was between 13:00 and 17:00, and it was unified as much as possible within the individual, and all analyzes were performed in the same laboratory.

(I) Measurement of cortisol in saliva It was measured by a method based on the RIA method (tube solid phase method). Specifically, using a kit for measuring cortisol in blood and urine (Gamma Coat ^™ Cortisol (manufactured by DiaSorin)), an anti-cortisol antibody coated with 125 I-cortisol labeled with cortisol and iodine 125 in a sample, and React competitively. After completion of the reaction, the unreacted solution is removed by suction, and then the radiation dose of the antigen-antibody reaction product remaining in the tube is measured with a γ counter. The cortisol concentration in the sample was read from the obtained standard curve.
In order to enable the measurement of salivary cortisol, improvements were made so that serum and urine that were diluted 20-fold could be detected by sampling saliva without dilution.

(Ii) Measurement of s-IgA in saliva It was measured by a method based on the EIA method (competitive method). Specifically, using a measurement kit (Salimary Secretory IgA (Salimetrics)), the HRP-labeled anti-human s-IgA antibody was first reacted with the specimen, and then the reaction solution was applied to a plate coated with human s-IgA. A secondary reaction was performed by dispensing. After washing, a coloring solution (enzyme substrate solution; TMB) was added to cause a coloring reaction, and a reaction stopping solution was dispensed to stop the reaction. Subsequently, it measured with wavelength 450nm with the plate reader, and calculated s-IgA density | concentration from the obtained standard curve.

As shown in Table 2, in the implementation group, good results were obtained in the SCORAD test, keratin moisture measurement (SCH), and moisture transpiration measurement (TEWL). Improvement was seen. Growth hormone was also significantly increased compared to the control group. The amount of stratum corneum and the amount of water transpiration has a direct influence on the symptoms of atopic dermatitis, and growth hormone is considered to have an indirect influence on the symptoms because it is related to the growth of the skin. Therefore, when the underwear of the working group is worn, it is considered that it greatly contributes to the improvement of symptoms.

According to the present invention, even when a patient with atopic dermatitis wears for a long time, the discomfort of the affected area and the deterioration of symptoms are unlikely to occur, and the underwear for patients with atopic dermatitis can be used safely. Can be provided.

In an Example, it is the schematic which shows the location which measures a keratin water content and a water | moisture content transpiration | evaporation amount.

Claims (3)

It is an underwear for atopic dermatitis patients comprising a knitted fabric of a reversible structure in which fibers made of thermoplastic elastomer and cotton are knitted,
Fibers made of the thermoplastic elastomer are arranged on the skin side, cotton is arranged on the outside,
The thermoplastic elastomer is a polyamide-based elastomer , and the proportion of fibers made of the thermoplastic elastomer is 5% by weight or more,
The bending resistance measured by a method according to JIS L 1018 is 1 to 10 cN, and
When immersed in water for 1 hour, dehydrated for 5 minutes, and then left in an atmosphere of 20 ° C. and 65% RH, the time until the moisture content reaches 5% is 60 minutes or less,
The water absorption rate measured by a method according to JIS L 1907 is 5 to 15 cm, or
An atopic dermatitis patient's underwear characterized by having a diffusion diameter of 1.8 to 6.0 cm after 1 minute of dropping a 100 gL of a 2 g / L benzoperpurine aqueous solution. 2. The atopic dermatitis patient according to claim 1, wherein the bending resistance measured by a method according to JIS L 1018 after washing 10 times according to a method according to JIS L0844 is 5 to 30 cN. underwear. The underwear for atopic dermatitis patients according to claim 1 or 2, wherein the thermoplastic elastomer is a polyether block amide copolymer.