JP4973507B2 - Chromatography apparatus and control apparatus for chromatography apparatus - Google Patents

Description

  The present invention relates to a chromatography column apparatus in which a piston (lid) of a column is moved up and down by a plurality of jacks arranged around the column, and a control apparatus used therefor.

  Conventionally, a liquid chromatography apparatus has been used to separate and purify each component from a mixed solution containing a plurality of components. The chromatography apparatus is configured by filling a cylindrical column with an adsorbent, and both ends of the column are covered with a pair of lids. In general, one of the lids is fixed to the column, and the other functions as a piston configured to reciprocate inside the column.

  A device such as a jack attached to a lid that reciprocates inside the column (movable lid) is often arranged in series with the column (for example, Patent Document 1). However, when the column and the jack are arranged in series, a space having a height that is a combination of the height of the column and the jack is required as a space for installing the chromatography apparatus. In addition, when using a large-diameter column having a diameter exceeding 1 m, in the configuration as in Patent Document 1, the central portion of the movable lid is pushed by a single jack, so that the entire movable lid can be pushed uniformly. It becomes difficult. Furthermore, in order to apply pressure to a large movable lid, it is necessary to increase the rod diameter of the jack to ensure the strength, which increases the weight.

  Therefore, a chromatographic apparatus in which a plurality of jacks are arranged around the column so as to be parallel to the column has been proposed (Patent Document 2). In the chromatography apparatus described in Patent Document 2, the movable lid cannot be moved up and down in a horizontal state unless the movements of a plurality of jacks are synchronized.

In Patent Document 2, an electromagnetic valve is provided in a hydraulic line that supplies hydraulic oil to each of a plurality of jacks in order to cope with the above problem. Moreover, the sensor which measures the rod height of each of several jacks is provided. The solenoid valve is controlled by a control unit that receives the measured value obtained by the sensor.
JP-A-2005-321302 JP-A-8-94602

  In Patent Document 2, the control unit turns on / off the solenoid valve (that is, controls the flow of the hydraulic oil itself) or whether the solenoid valve opens (controls the flow rate of the hydraulic oil) ) Is not listed. In the former case, for example, when the movable lid is raised by 20 cm, after opening all the solenoid valves, the control unit detects the rod position of each jack with a sensor, and the hydraulic oil is applied to the jack whose rod height is raised by 20 cm. The supply is considered to be stopped sequentially. In this case, since the flow rate of the hydraulic oil supplied to each jack tends to be non-uniform, the stroke length of the rod of each jack is displaced in the ascending process, and the level of the movable lid tends to be impaired.

  On the other hand, when the flow rate is controlled for each hydraulic oil supply line to each jack using an electromagnetic flow rate adjusting valve, the movable lid can be moved while maintaining the level more accurately than the former. However, the electromagnetic flow rate adjusting valve is more complicated in configuration than the electromagnetic open / close valve and the manual flow rate valve, and is expensive.

  This invention is made | formed in view of this subject, and it aims at providing the chromatography apparatus which can be moved keeping a cover body horizontal at low cost. In particular, the present invention aims to reduce the manufacturing cost with a simple apparatus configuration for a chromatography apparatus capable of reciprocating a lid of a chromatography column having a large diameter exceeding 1 m while maintaining the horizontal. To do.

  In the present invention, an electromagnetic valve that opens and closes the flow path is provided in a flow path that supplies hydraulic oil to a plurality of jacks arranged around the column, and the rod that has reached a predetermined position after opening the electromagnetic valves of all the flow paths The operation to stop the movement is repeated in order. Each channel is provided with an inexpensive manual flow rate adjusting valve downstream of the solenoid valve to equalize the flow rate. Specifically, the present invention provides the following.

(1) A fixed lid, a movable lid facing the fixed lid, a cylindrical column arranged between the fixed lid and the movable lid, and a round trip arranged in the extending direction of the column arranged around the side of the column A chromatography apparatus comprising a plurality of jacks having reciprocating rods that move,
A plurality of sensors provided for each of the plurality of jacks, each detecting a stroke length of a reciprocating rod of each jack and outputting an electric signal;
A plurality of flow paths connected to each of the plurality of jacks and through which a working fluid flows;
A plurality of electromagnetic switching valves provided in each of the plurality of flow paths to open and close the flow paths;
A control unit that individually controls ON-OFF of the plurality of electromagnetic switching valves using an electrical signal output from each of the plurality of sensors as an input value;
A chromatographic apparatus further comprising: a manual flow rate adjustment valve provided in each of the plurality of flow paths for adjusting the flow rate of the fluid .
( 2 ) The control unit outputs a full valve opening signal that opens all of the plurality of flow paths to the plurality of electromagnetic switching valves, and then the stroke length of the plurality of reciprocating rods reaches a predetermined expansion / contraction width. The chromatography apparatus according to (1), which is configured to move the movable lid to a predetermined position by repeating an operation of outputting a sequential stop signal for stopping the reciprocation in order from the reciprocating rod.
( 3 ) a fixed lid, a movable lid facing the fixed lid, a cylindrical column arranged between the fixed lid and the movable lid, and a round trip arranged in the extending direction of the column arranged around the side of the column A control device for a chromatography apparatus comprising a plurality of jacks each having a reciprocating rod that moves and a flow path through which a working fluid flows .
A plurality of sensors provided for each of the plurality of jacks, each detecting a stroke length of a reciprocating rod of each jack and outputting an electric signal;
A plurality of electromagnetic switching valves provided in each of the working fluid flow paths connected to each of the plurality of jacks and opening and closing the fluid flow paths;
A control unit that individually controls ON-OFF of the plurality of electromagnetic switching valves using an electrical signal output from each of the plurality of sensors as an input value;
A control device for a chromatography apparatus , comprising: a manual flow rate adjustment valve that adjusts the flow rate of the fluid provided in each of the plurality of flow paths .

  ADVANTAGE OF THE INVENTION According to this invention, the chromatography apparatus which can be moved keeping a cover body horizontal can be provided at low cost.

  Hereinafter, the present invention will be described in detail with reference to the drawings. In the following, the same members are denoted by the same reference numerals, and description thereof is omitted or simplified. FIG. 1 is an overall perspective view of a chromatography apparatus 1 including a control device 5 according to an embodiment of the present invention.

  The chromatography apparatus 1 is installed in a state where the column 20 is supported by the support pressure unit 10. The column 20 is cylindrical, and a movable lid 21 and a fixed lid 22 are attached to both ends that open. The movable lid 21 has substantially the same size as the inner diameter of the column 20 and can reciprocate in the vertical direction (the extending direction of the column 20) in contact with the inner wall of the column 20. The diameter of the fixed lid 22 is larger than the diameter of the column 20 and is fixed so as to close the open end of the column 20. Note that the fixed lid 22 may be reciprocally movable by arranging a jack for moving the fixed lid 22.

  The support pressure unit 10 includes a movable frame 11, a fixed frame 12, a jack 17 and a support base 30. The movable frame 11 is connected to the movable lid 21 and moves the movable lid 21 up and down. The fixed frame 12 is connected to the fixed lid 22 and placed on the support base 30. The support base 30 supports the fixed frame 12 that supports the column 20 and supports the plurality of jacks 17.

  A plurality of jacks 17 are arranged so as to surround the side surface of the column 20, and in this example, four jacks 17 are arranged. As shown in FIG. 2, each jack 17 has a cylinder 172 to which oil as a fluid is supplied, and a reciprocating rod 171 connected to a piston 173 in the cylinder 172. Each jack 17 is a fluid pressure drive type in which the reciprocating rod 171 is reciprocated in the extending direction of the cylinder 172 by fluid pressure. The jack 17 is a jack that moves the movable lid 21. In the present embodiment, a jack 18 that moves the column 20 is also provided in order to attach and detach the column 20.

  The tip of the reciprocating rod 171 is connected to a connecting rod 112 that constitutes the movable frame 11. Two connecting rods 112 are provided so as to face each other across the column 20. In this example, four supporting rods 111 extend from the connecting rod 112 to the movable lid 21. The two connecting rods 112 are connected to two reinforcing rods 113 orthogonal to them.

  In this example, the support rod 111 extends obliquely with respect to the lid surface of the movable lid 21, and the angle formed by the lid surface and the support rod 111 is approximately 45 to 75 °. The connection point between the support rod 111 and the movable lid 21 is 60% of the length from the liquid introduction path 211 provided at substantially the center of the movable lid 21 to the outer edge (that is, substantially the same length as the radius of the movable lid 21). It is in the range of 70% or less. More specifically, the mounting position of the support rod 111 draws a circle having a radius of about 60% to 70% of the radius of the circle drawn by the outer edge of the movable lid 21.

  If the mounting position of the support rod 111 is moved inward in this way, deformation of the movable lid can be prevented and pressure applied in the column cross-sectional direction can be equalized. Therefore, since the necessity of increasing the strength by increasing the thickness of the movable lid 21 is reduced, the chromatography device 1 can be reduced in weight by reducing the thickness of the movable lid 21. Similarly, the fixed lid 22 supported by the fixed frame 12 having the same configuration as that of the movable frame 11 can be reduced in weight. Furthermore, by configuring the movable frame 11 and the fixed frame 12 with a frame body, the mechanism (support pressure unit) that supports and pressurizes the column 20 can be reduced in weight compared to a conventional apparatus such as Patent Document 1.

  In this way, the column 20 is disposed between the movable lid 21 and the fixed lid 22, and the column 20 is installed so as to float from the installation surface by supporting the fixed lid 22 on the support frame 12. The extending direction of the column 20 is perpendicular to the installation surface, and the cross section of the column 20 is substantially horizontal to the installation surface. Since the chromatography apparatus 1 has the movable lid 21 as the upper side and the fixed lid 22 as the lower side, the following description will be made with the movable lid 21 side as the upper side and the fixed lid 22 side as the lower side.

  In the chromatography apparatus 1 of this embodiment, since the plurality of jacks 17 are arranged around the column 20, the apparatus can be reduced in height as compared with the apparatus of Patent Document 1 in which the piston engine is arranged in series with respect to the column 20. . On the other hand, when a plurality of jacks 17 are used, it is necessary that the length of each reciprocating rod 171 varies so that the level of the movable lid 21 is not impaired. Therefore, in the present invention, the plurality of jacks 17 are provided with sensors 41 for measuring the stroke lengths of the respective forward double-acting rods 171, and the stroke lengths of the plurality of jacks 17 are made uniform by controlling the opening / closing of electromagnetic switching valves 44 described later. Like that.

  FIG. 2 is a hydraulic circuit diagram showing a configuration of a hydraulic drive system that drives the jack 17 with hydraulic oil. Hereinafter, when differentiating a plurality of members having the same configuration (jack 17, sensor 41, electromagnetic switching valve 44, flow path 53, etc.), they are referred to as first, second,. Further, in FIG. 2, reference numerals A to D are attached in order from the first member so that a plurality of members having the same configuration can be distinguished, and part of the reference numerals for the members having the same configuration are omitted. A hydraulic oil flow path 53 is connected to the cylinder 172 of each jack 17. Each flow path 53 includes a lower flow path 531 that supplies and discharges hydraulic oil in the lower chamber 172b of the cylinder 172, and an upper flow path 532 that supplies and discharges hydraulic oil in the upper chamber 172a of the cylinder 172. It has two flow paths.

  The lower flow path 531 of each flow path 53 has one end connected to the lower chamber 172 b of the cylinder 172 and the other end connected to the electromagnetic switching valve 44. Further, one end of the upper flow path 532 of each flow path 53 is connected to the upper chamber 172 a of each cylinder 172, and the other end is connected to the electromagnetic switching valve 44.

  When the raising solenoid 441 is turned on, the electromagnetic switching valve 44 is connected to the lower flow path 531 and the supply pipe 511, and is connected to the upper flow path 532 and the return pipe 521, and the lowering solenoid 442 is turned on. In this case, the lower flow path 531 and the return pipe 521 are connected, and the upper flow path 532 and the supply pipe 511 are connected. In this embodiment, since a double pilot operated check valve 42 described later is provided in each flow path 53, when both the lifting solenoid 441 and the lowering solenoid 442 are turned off, the lower flow path 531 and Although the upper flow path 532 is configured to be connected to the return pipe 521, both the lower flow path 531 and the upper flow path 532 may be configured to be blocked from the supply pipe 511 and the return pipe 521. Good.

  The electromagnetic switching valve 44 is controlled by the control unit 45, and the connection between the lower flow path 531 and the upper flow path 532, the supply pipe 511 and the return pipe 521 is switched by ON / OFF of the raising solenoid 441 and the lowering solenoid 442. Open and close the hydraulic oil flow path. In this way, by supplying the hydraulic oil to the upper chamber 172a or the lower chamber 172b in the cylinder 172, the piston 173 in the cylinder 172 is moved up and down. The flow rate of the hydraulic oil flowing through each flow path 53 is adjusted by manually adjusting the flow rate adjustment valve 43.

  Each supply pipe 511 is connected to a supply main pipe 51 whose other end is connected to the oil tank 50, and each return pipe 521 is connected to a return main pipe 52 led to the oil tank 50 at the other end. A pump P is provided in the middle of the supply main pipe 51, and hydraulic oil in the oil tank 50 is sent from the supply main pipe 51 to each supply pipe 511 by the pump P driven by the motor M, and each lower flow It is sent to each cylinder 172 via the path 531 or each upper flow path 532. The hydraulic oil discharged from each cylinder 172 is sent from each return pipe 521 to the return main pipe 52 via the upper flow path 532 or the lower flow path 531 and returned to the oil tank 50.

  A check valve 42 is provided in the middle of each flow path 53. Each lower flow path 531 is provided with a manual flow rate adjustment valve 43 between the electromagnetic switching valve 44 and the check valve 42. When the solenoid for raising 441 and the solenoid for lowering 442 of the electromagnetic switching valve 44 are OFF, that is, when the movable lid 21 is stopped, the hydraulic oil slightly leaks when trying to block the flow path 53 with the electromagnetic switching valve 44 alone. The piston may move due to the load, but by providing the check valve 42, the flow path 53 can be reliably shut off, so that such a possibility can be avoided.

  In the present embodiment, a double pilot operated check valve is used as the check valve 42. In a normal check valve, the hydraulic oil flows from the electromagnetic switching valve 44 side to the cylinder 172 side, but only shuts off in the opposite direction so that it does not flow. However, the double pilot operated check valve , When a pressure equal to or higher than the set pressure is detected in the lower flow path 531 between the electromagnetic switching valve 44 and the check valve 42, the valve 422 on the upper flow path 532 side is opened and the cylinder 172 is connected to the electromagnetic switching valve 44. The upper flow path 532 is in communication. When a pressure equal to or higher than the set pressure is detected in the upper flow path 532 between the electromagnetic switching valve 44 and the check valve 42, the valve 421 on the lower flow path 531 side opens and the lower flow between the cylinder 172 and the electromagnetic switching valve is opened. The path 531 is configured to communicate.

  As a result, when the raising solenoid 441 of the electromagnetic switching valve 44 is turned ON and the hydraulic oil is supplied to the lower chamber 172b of the cylinder 17 by the pump P via the lower flow path 531, the upper flow path 532 is generated by the supply pressure of the hydraulic oil. The side valve 422 is opened, and the hydraulic oil pushed out from the upper chamber 171a of the cylinder 17 is sent to the return pipe 521 and the return main pipe 52 via the upper flow path 532 and returned to the oil tank 50, so that smooth The piston 173 rises. On the contrary, when the lowering solenoid 442 of the electromagnetic switching valve 44 is turned on and the hydraulic oil is supplied to the upper chamber 171a of the cylinder 17 by the pump P via the upper flow path 532, the lower flow path 531 is caused by the supply pressure of the hydraulic oil. The side valve 421 is opened, and the hydraulic oil pushed out from the lower chamber 172b of the cylinder 17 is sent to the return pipe 521 and the return main pipe 52 via the lower flow path 532, and is returned to the oil tank 50, thereby smoothly The piston 173 descends.

  When the movable lid 21 is raised, hydraulic oil is supplied to the lower chamber 172b to raise the piston 173 and push up the reciprocating rod 171. At this time, the hydraulic oil pushed out from the upper chamber 172 a is discharged to the upper flow path 532 and returned to the oil tank 50. When the movable lid 21 is lowered, the hydraulic oil is supplied to the upper chamber 172a, the piston 173 is pushed down, and the reciprocating rod 171 is lowered. At this time, the hydraulic oil is pushed out from the lower chamber 172 b and discharged through the upper flow path 532.

  In the present invention, the control unit 45 individually controls the opening and closing of the plurality of electromagnetic switching valves 44 provided in each channel 53, so that the reciprocating rods of the plurality of jacks 17 are automatically controlled. Ascending / descending operations are performed in synchronization with the stroke length 171. FIG. 3 is a flowchart showing a control operation by the control device 40 in the present embodiment. FIG. 4 shows an example of an operation screen displayed on a computer or the like for performing a control operation.

  First, one of the plurality of jacks 17 is arbitrarily selected while all the plurality of jacks 17 are stopped. As a first step S1, the stroke length of the reciprocating rod 171A of the reference jack 17A is measured with reference to the selected jack (for example, the first jack 17A). The measured stroke length of the reciprocating rod 171A of the reference jack 17A is input to the control unit 45 and stored as the reference height (h1).

  The control unit 45 includes an input unit to which electric signals output from the sensors 41 and input values from input means such as a mouse and a keyboard are input, an arithmetic processing circuit such as a programmable logic controller, and an arithmetic unit. There is an output section that outputs the results. The reference height h1 is measured by a sensor (first sensor 41A) provided in the reference jack 17A, and is automatically input to the control unit 45 as an electric signal output from the first sensor 41A.

  In the subsequent step S2, the expansion / contraction width (hereinafter referred to as “lap height”) Δh of the reciprocating rod 171 per a continuous series of operations (referred to as “one lap”) is input to the control unit 45 and stored. FIG. 4 shows a state in which 20 mm is input as a lap height Δh on an operation screen such as a graphical user interface displayed on the display screen of the computer.

  After inputting the lap height Δh, the controller 45 sends a signal for opening all the channels to the electromagnetic switching valves 44 provided in the plurality of channels 53 (step S3). A full valve opening signal for “opening” all the electromagnetic switching valves 44 is sent to the electromagnetic switching valve 44 via a telecommunication line indicated by a broken line. Thereby, hydraulic oil is supplied to all the cylinders 171 of each jack 17, and the reciprocating rod 171 moves up or down.

  Here, as described above, each flow path 53 is provided with a manual flow rate adjustment valve 43, and before opening the electromagnetic switching valve 44, the flow rate adjustment valve 43 of each flow path 53 is manually operated in advance. Keep the set flow rate. Since the manual flow rate adjustment valve 43 is less expensive than the electromagnetic flow rate adjustment valve that can be automatically controlled, according to this embodiment, Patent Document 2 in which an electromagnetic flow rate adjustment valve is provided in each flow path is disclosed in Patent Document 2. A cheaper chromatographic apparatus can be obtained.

  The flow rate adjustment valve 43 is preferably adjusted so that the flow rate of the hydraulic oil flowing through each flow path 53 is as constant as possible. However, it is completely possible that a difference in the flow rate of the hydraulic oil occurs in the plurality of flow path 53 pipes. It is difficult to avoid. In the present invention, the movement of the reciprocating rod 171 that has reached a predetermined stroke length is stopped by the sensor 41, the electromagnetic switching valve 44, and the control unit 45, so that the movable lid 21 can be operated even if there is a difference in the flow rate of each flow path 53. So that the level is maintained.

  Specifically, after the electromagnetic switching valves 44 of all the flow paths 53 are opened and all the reciprocating rods 171 start to rise or descend, the respective reciprocating rods 171 are detected by the sensors 41 provided in the jacks 17 in step S3. The stroke length is measured and the measurement result is output as an electrical signal. The electric signal sent from each sensor 41 is sent to the control unit 45 via an electric communication line indicated by a broken line and automatically inputted.

  If the value of the output signal received from the sensor 41 is a value obtained by adding the lap height Δh to the reference height h1 measured and input in step S1, the control unit 45 is a jack to be measured by the sensor 41. An output signal for switching the flow path from “open” to “closed” is output to the electromagnetic switching valve 44 provided in the flow path 53 connected to 17 (step S4). On the other hand, if the output signal from the sensor 41 does not reach the predetermined value (h1 + Δh), the electromagnetic switching valve 44 of the flow path 53 of the jack 17 to be measured by the sensor 41 is in a state in which the flow path remains open. To do.

  In this way, when all of the plurality of reciprocating rods 171 reach a predetermined expansion / contraction width (h1 + Δh), all the electromagnetic switching valves 44 are closed (step S5). When the controller 45 detects that all the electromagnetic switching valves 44 are closed, the process returns to step S1. Here, although steps S1 to S5 are one lap, steps S3 to S5 may be one lap. In this case, as shown in FIG. 3, instead of measuring the stroke length of the reference jack in step S1, the expansion / contraction width (h1 + Δh) of all the jacks moved by the previous lap is set as the stroke length h1 of the reference jack. What is necessary is just to update the value of h1.

  Alternatively, the extension length of the jack to be stopped in step S4 is obtained by adding the value obtained by multiplying the extension width (lap height) Δh per lap by the number of laps n and the reference height h1 measured in step S1. (H1 + Δh × n) may be used as a predetermined expansion / contraction width in the wrap. For example, first, steps S1 to S5 are executed, and after the stroke length of all the reciprocating rods 171 reaches (h1 + Δh), the process returns to step S3. Then, as the second lap, the movement is stopped from the reciprocating rod 171 whose stroke length has reached (h1 + Δh × 2) in step S4. In step S4 of the third lap that follows step S5 of the second lap, the stroke length is stopped from the reciprocating rod 171 that has reached (h1 + Δh × 3), and thereafter the same may be performed.

  While returning from step S5 to step S1 (or step S3), a free time (lap interval time) of several seconds to several tens of seconds may be provided, and a plurality of laps may be continued without providing a lap interval time. Also good. FIG. 4 shows a state where the lap interval time is set to 1 second. In the case of setting as shown in FIG. 4, after all the electromagnetic switching valves 44 are closed in step S5, the state where all the electromagnetic switching valves 44 are turned off is held for 1 second, and after one second, step S1 (or S3). To resume.

  When the above operation is repeated and the movable lid 21 reaches a desired position (step S6), the process ends instead of returning to step S1 (or step S3). If the value of Δh is decreased, the number of laps increases, but the stroke length error between the plurality of reciprocating rods 171 decreases.

  As a design example, instead of the electromagnetic switching valve 44 that opens and closes the flow path 53, an electromagnetic flow rate adjustment valve that automatically controls the flow rate is provided, and the manual flow rate adjustment valve 43 is not provided. In this case, the cost required to control one jack was 350,000 yen.

  On the other hand, as shown in FIG. 2, the electromagnetic flow rate adjustment valve is replaced by a manual flow rate adjustment valve 43, and an electromagnetic open / close control valve is provided upstream of the manual flow rate adjustment valve 43. As a result, one jack can be controlled with an inexpensive and simple member, and the cost required to control one jack is 35,000 yen. When four jacks 17 for moving the movable lid 21 and four jacks 18 for moving the column 20 to detach the column 20 from the fixed lid 22 are provided, a jack that requires 2.8 million yen is required if an electromagnetic flow valve is used. The tuning control cost is 280,000 yen according to the present invention.

  Thus, according to the present invention, it has been shown that a system for synchronizing a plurality of jacks for moving a chromatography apparatus can be simplified and the cost can be reduced.

  The present invention can be used in a liquid chromatography apparatus.

1 is a perspective view of a chromatography apparatus according to a first embodiment of the present invention. The hydraulic circuit diagram of the hydraulic system provided in the chromatography apparatus. The flowchart which shows the control action of the said hydraulic system. The figure which shows the operation screen which controls the said hydraulic system.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Chromatography apparatus 10 Supporting pressurization apparatus 11 Movable frame 12 Support frame 17 Movable lid up / down jack 18 Column up / down jack 20 Column 21 Movable lid 22 Fixed lid 30 Support base 111 Support rod 111 Contact rod 113 Reinforcing rod 113

Claims (3)

A fixed lid, a movable lid facing the fixed lid, a cylindrical column disposed between the fixed lid and the movable lid, and a reciprocating motion arranged around the side of the column and reciprocating in the extending direction of the column A chromatography apparatus comprising a plurality of jacks having moving rods,
A plurality of sensors provided for each of the plurality of jacks, each detecting a stroke length of a reciprocating rod of each jack and outputting an electric signal;
A plurality of flow paths connected to each of the plurality of jacks and through which a working fluid flows;
A plurality of electromagnetic switching valves provided in each of the plurality of flow paths to open and close the flow paths;
A control unit that individually controls ON-OFF of the plurality of electromagnetic switching valves using an electrical signal output from each of the plurality of sensors as an input value;
A chromatographic apparatus further comprising: a manual flow rate adjustment valve provided in each of the plurality of flow paths for adjusting the flow rate of the fluid . The control unit outputs a full valve opening signal that opens all of the plurality of flow paths to the plurality of electromagnetic switching valves, and then a reciprocating rod whose stroke length has reached a predetermined expansion / contraction width among the plurality of reciprocating rods. The chromatography apparatus according to claim 1, wherein the movable lid is moved to a predetermined position by repeating an operation of outputting a sequential stop signal for stopping the reciprocation in order. A fixed lid, a movable lid facing the fixed lid, a cylindrical column disposed between the fixed lid and the movable lid, and a reciprocating motion arranged around the side of the column and reciprocating in the extending direction of the column A control device for a chromatography apparatus comprising a plurality of jacks each having a moving rod and connected to a flow path through which a working fluid flows ,
A plurality of sensors provided for each of the plurality of jacks, each detecting a stroke length of a reciprocating rod of each jack and outputting an electric signal;
A plurality of electromagnetic switching valves provided in each of the working fluid flow paths connected to each of the plurality of jacks and opening and closing the fluid flow paths;
A control unit that individually controls ON-OFF of the plurality of electromagnetic switching valves using an electrical signal output from each of the plurality of sensors as an input value;
A control device for a chromatography apparatus , comprising: a manual flow rate adjustment valve that adjusts the flow rate of the fluid provided in each of the plurality of flow paths .

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