JP4958275B2 - Needle integrated sensor - Google Patents

Description

  The present invention relates to a biosensor used in a simple body fluid measuring device or the like for collecting a liquid sample such as blood by piercing a subject such as a human and simply analyzing its characteristics. The present invention relates to a needle-integrated sensor in which a puncture needle and a sensor are integrated so that a subject can easily perform measurement.

  Conventionally, as a simple body fluid measuring device that punctures a needle such as a human to collect a body fluid such as blood and easily analyzes its characteristics, for example, a blood glucose level measuring device for a diabetic patient to measure a blood glucose level is used. It has been put into practical use.

  The blood glucose level measurement device that is currently in practical use has a puncture needle for draining blood, a sensor that collects the drained blood and converts it into a current value, etc., and a measuring instrument are separated. Because it is a measurement kit, blood is discharged by inserting a needle into the skin using a puncture device, then a sensor is attached to the measuring instrument, and the discharged blood is collected and measured in the cavity of the sensor. ing.

  In this way, in the measurement kit in which the puncture needle is separated from the measuring instrument and the sensor, the blood must be discharged with the puncturing needle and then transferred to the measuring instrument. It is inconvenient for oneself to drain blood and measure. For this reason, a measurement kit that can attach a sensor and a puncture needle to a measuring instrument is desired.

As a measurement kit in which a sensor and a puncture needle can be detachably attached to a measuring instrument, there is a kit using a lancet integrated sensor proposed in Patent Document 1.
Specifically, as shown in FIG. 11, the lancet-integrated sensor disclosed in Patent Document 1 forms a substrate 50 on which an electrode pattern 51 is printed and a reaction reagent is applied, and a space 53 in which a lancet 52 can be accommodated. The lancet 52 is accommodated in the space 53 of the sensor body in combination with the substrate 54, and the lancet 52 is driven in the longitudinal direction in the space 53 by an external driving means. The needle 52a can be moved in and out from the sensor body tip 53a.

  With such a lancet-integrated sensor attached to the measurement device, the lancet 52 is driven and the needle 52a is pierced into the skin with the tip of the sensor body pressed against the subject. As a result, blood is discharged to the skin surface, and further, the needle 52a is stored in the space 53 in the sensor body, so that blood is collected in the space 53, and the potential difference generated by reacting with the reagent there. Is detected by the electrode.

WO2002-056769

  However, since such a lancet-integrated sensor drives the needle 52a in the space 53 that accommodates the sample, the size of the space 53 is the size necessary for driving the needle 52a, and the amount of blood required for measurement However, it becomes more than the measurement kit in which the sensor and the puncture needle are separated. This makes the needle thicker or pierces the needle deeper, and increases the pain when the subject is collected. In addition, it is difficult to reduce the size of the lancet-integrated sensor provided with the sensor body and the needle drive mechanism in an integrated manner.

  On the other hand, Patent Document 1 also proposes providing a cavity for storing blood separately from the lancet storage space in the sensor body. In this case, since the cavity size can be set independently of the lancet, it can be considered that the amount of collected blood can be reduced. However, despite the fact that the piercing position by the lancet and the cavity entrance are arranged at different positions, the mechanism for effectively accommodating the blood discharged on the skin surface and the blood adhering to the needle into the cavity is as follows: Nothing is disclosed.

  The present invention has been made in view of the circumstances as described above, and an object of the present invention is to provide a needle-integrated sensor in which a puncture needle is fixed to a sensor, and to obtain a sample reaction space (cavity) size and sampling necessary for measurement. Provided is a needle integrated sensor capable of reducing blood volume and effectively introducing blood discharged to the skin surface into the cavity even when the needle piercing position and the cavity entrance are separated from each other. There is.

  In the needle-integrated sensor in which the puncture needle is fixed to the sensor, the puncture needle is fixed in a protruding state in order to perform a puncture necessary for discharging a liquid sample such as blood from the subject to the skin surface. It will be. For this reason, the tip of the puncture needle and the entrance of the sample reaction space must be spaced apart from each other. However, a flow path through which the liquid sample can flow is provided from the tip of the puncture needle to the entrance of the sample reaction space. This can be solved. Therefore, the inventors attach a flow path forming body that forms a flow path through which the liquid sample can flow from the tip of the puncture needle to the entrance of the sample reaction space, and the liquid sample is effectively passed through the flow path. Various configurations introduced into the sample reaction space have been studied, and the present invention has been completed.

That is, the needle-integrated sensor of the present invention, Ru integrally includes a detector for detecting reaction portion the puncture needle for discharging the liquid sample from the subject, wherein the liquid sample is contained, and the result of the reaction unit And a needle-integrated sensor main body provided so that the puncture needle, the reaction portion, and the detection portion are integrally movable, and a flow path from the contact portion of the subject to the reaction portion, A needle-integrated sensor provided with a flow path forming body in which the through hole is provided, and the puncture needle is inserted into the through hole, and communicates the through hole and the outside of the flow path forming body. A ventilation path is provided in the flow path forming body.

The needle-integrated sensor of the present invention is used as a needle-integrated sensor main body, not a single puncture needle, and is pierced into the subject's skin to discharge a liquid sample. The material of the flow path forming body is not particularly limited, and may be a rigid body, an elastic body, or a viscoelastic body . It is composed of an elastic body or a viscoelastic body that changes the length in the puncture direction so that the puncture needle can be projected and retracted from the through hole. This is because, by pulling out the puncture needle that has pierced the skin with the elastic restoring force of the flow path forming body itself, the measuring instrument only needs to have a drive mechanism for piercing the puncture needle.

  The air passage may be provided at any position of the flow path forming body as long as it is provided so as to communicate the through hole and the outside of the flow path forming body. Therefore, the air passage may be a communication hole penetrating at an appropriate position on the peripheral wall surface of the through-hole constituting the through-hole, or may be a recess provided in a mounting portion of the sensor body. It may also be a gap formed in the attachment part between the sensor body and the flow path forming body with the needle-integrated sensor body attached, or in a state in contact with the subject, It may be a notch provided on the subject contact surface of the flow path forming body or a combination thereof so that the through hole communicates with the outside of the flow path forming body.

  Preferably, the ventilation path is provided in a sensor main body attachment portion of the flow path forming body. Here, the attachment part of the sensor body means that when the puncture needle is inserted into the through-hole, if the air passage is not formed, the tip part of the sensor body and the flow path forming body are in contact with each other. For example, when the flow path forming body is bonded to the sensor body by bonding or welding, the bonding portion is referred to, and when the flow path forming body is attached by insertion, the insertion portion is referred to. Accordingly, when the ventilation path is provided in the mounting portion, for example, a part of a surface on which the needle-integrated sensor body is mounted in the flow path forming body (hereinafter referred to as “sensor body mounting surface”) is formed as a flow path. When notching so as to communicate with the outside of the body, when providing a groove extending to the outer peripheral surface of the flow path forming body on the sensor body mounting surface, the sensor body mounting surface itself is made rough so that air can flow in and out. Cases. In addition, when the flow path forming body and the sensor body are attached by insertion, the flow through the wall surface of the flow path forming body, which is an outer fitting portion of the sensor main body, or in the case of loose fitting The ventilation path may be formed by a clearance between the path forming body and the sensor body.

  In the case where the air passage is provided in the attachment portion of the sensor body, the air passage is preferably provided so that the reaction portion entrance is located in the middle of the air passage or in the vicinity of the air passage entrance. Specifically, when the reaction part entrance is disposed in a through hole formed in the flow path forming body, the entrance of the air passage communicating with the through hole is more than the puncture needle. Also, it is preferable to arrange it so as to be close to the entrance of the reaction part. In addition, when the reaction part inlet is not disposed in the through hole, the vent path is arranged so that the reaction part inlet is disposed in the middle of the vent path from the through hole to the outside of the flow path forming body. Is preferably provided.

  It is preferable that a liquid outflow prevention mechanism is provided in the air passage. This is to prevent the liquid sample from leaking out of the flow path forming body through the air passage because the through hole serving as the liquid sample passage and the air passage are communicated with each other. As a liquid outflow prevention mechanism provided in the air passage, for example, a bent portion may be provided in the middle of the air passage, or a protective wall for preventing liquid outflow may be provided in the flow path forming body.

  In addition, it is preferable that the liquid sample passing through the through-hole is preferentially flowed into the reaction part rather than flowing through the ventilation path. This means that the through-hole is attached to the sensor body and further to the reaction part entrance. This is particularly required when it is provided in the vicinity. The preferential flow of the liquid sample into the reaction section over the ventilation path is achieved by appropriately setting the size of the ventilation path entrance and the reaction section entrance, the positional relationship between the ventilation path and the reaction section entrance, and the like. However, it is preferable that a surfactant is applied in the vicinity of the entrance of the reaction section. The application of the surfactant is not limited to the reaction part entrance, and may be applied to a part where the liquid sample is to flow preferentially.

  The needle-integrated sensor of the present invention includes a flow path forming body capable of guiding a liquid sample discharged by puncturing at a reaction portion entrance arranged away from the tip of a puncture needle, and the flow path forming The body is provided with an air passage that connects the through-hole serving as the flow path and the outside of the flow path forming body, so that it is possible to effectively introduce the liquid sample discharged by puncture into the reaction part. The amount of collected liquid sample can be reduced.

An embodiment of a needle integrated sensor of the present invention will be described with reference to the drawings.
FIG. 1 is a cross-sectional view of the needle integrated sensor of the present embodiment.
The needle-integrated sensor of the present embodiment has a needle-integrated sensor main body 10 in which the puncture needle 2 is fixed so that the tip of the puncture needle protrudes on one surface of a flat plate-like detection unit 1 as shown in FIG. A flow path forming body 20 as shown in FIG. 3 is attached, and the puncture needle 2 is inserted into the through hole 22 at the center of the flow path forming body 20.

  The flat plate detection unit 1 is obtained by bonding two electrically insulating substrates 1a and 1b with an adhesive or the like. 1 and 2, 1c is an adhesive part. At the tip of the detection unit 1, there is a rectangular portion to which no adhesive is applied, and this rectangular non-adhesive portion forms a reaction unit 3 that accommodates a liquid sample such as blood. In addition, there is a thin streaky adhesive non-applied part from the reaction part 3 to the side edge of the insulating substrate 1a. The adhesive non-applied part connects the reaction part 3 and the outside of the flat plate detection part 1 to each other. An air hole 3b that communicates is formed. In FIG. 2, 3 a is an entrance of the reaction unit 3.

  A pair of detection electrode patterns 4 are printed on the surface of the insulating substrate 1a on which the adhesive is applied, and the pattern is drawn so that each of the pair of electrodes 4 intersects the reaction part 3. It is. A reagent that reacts with a liquid sample such as blood is applied to the reaction unit 3. Therefore, the liquid sample accommodated in the reaction unit 3 reacts with the reagent, and the potential and current changes caused by the chemical change can be detected by the pair of electrodes 4. For example, when blood as a liquid sample is accommodated in the reaction unit 3, the potential change caused by the reaction with the reagent is detected by the electrode 4, and desired characteristics such as blood glucose level can be measured by the measurement unit. Yes.

  The puncture needle 2 is fixed by stacking the needle support substrate 5 on the surface of the substrate 1b to which the adhesive is not applied (sometimes referred to as “the outer surface of the insulating substrate”). As the puncture needle here, a hollow needle used for a general syringe, a solid needle having a sharp tip, a lancet needle, or the like can be used. Further, of the two substrates 1a and 1b of the flat plate detection unit 1, the needle-integrated sensor body 10 is attached to the measuring device on the outer surface of the insulating substrate 1a to which the puncture needle 2 is not attached. The mounting portion 6 is stacked.

  The flow path forming body 20 is composed of an elastic body or a viscoelastic body that can be deformed by a pressing force in the puncture direction and can be restored to its original shape by releasing the pressure. Specifically, natural rubber; synthetic rubber such as synthetic isoprene rubber, styrene rubber, nitrile rubber, chloroprene rubber and acrylic rubber; rubber-like elastic body such as silicone rubber and urethane rubber; heat such as ethylene-vinyl acetate copolymer Plastic elastomers; sponges such as polystyrene foam can be used.

  On the side of the flow path forming body 20 attached to the needle-integrated sensor main body 10, a fitting insertion portion 21 for fitting the tip of the sensor main body 10 is recessed. A through-hole 22 that penetrates from the bottom surface 21a of the insertion portion 21 to the subject contact surface 20a of the flow path forming body 20 is provided at the approximate center of the insertion portion 21 that is the sensor main body attachment portion. 22 stores the tip of the puncture needle 2. On the bottom surface 21a of the insertion portion, a groove 23a is formed in a radial direction from a position near the reaction portion entrance 3a, and a communication hole 23b penetrating the peripheral wall surface of the flow path forming body 20 at a position slightly above the groove 23a. Is perforated. The air passage 23 communicating with the outside of the flow path forming body 20 from the through hole 22 is formed by a combination of the groove 23a and the communication hole 23b, and a bending path in which the connection position of the groove 23a and the communication hole 23b is a bent portion. It has become.

  The needle-integrated sensor having the above-described configuration is attached to a measuring instrument 40 including a display unit 41, a measuring unit 42, a puncture spring 43, and a spring operation button 44 as shown in FIG. At the time of mounting, the puncture spring 43 is compressed by inserting the mounting portion 6 of the sensor integrated sensor body 10 into a setting portion (not shown) of the measuring instrument. Then, by pushing the spring operation button 44, the spring 43 is released from the compressed state, and accordingly, the needle-integrated sensor body 10 can be driven in the puncturing direction.

  In the compressed state (spring biased state) of the puncture spring, the bottom surface of the flow path forming body 20 is pressed against the subject's skin M, for example, a finger (see FIG. 5A), and the puncture needle 2 is held. When the button is operated in the direction in which the spring is extended, the needle-integrated sensor body 10 is pushed toward the skin M. Along with this, a pressure in the puncture direction is generated in the flow path forming body 20 attached to the tip of the needle-integrated sensor main body 10, and the flow path forming body 20 is deformed so as to be compressed in the puncture direction or expanded in the radial direction. . Since the puncture needle 2 attached to the distal end of the needle-integrated sensor body 10 is pushed out toward the skin M in the deformed state of the flow path forming body 20, the puncture is performed from the subject contact surface 20a of the flow path forming body 20. The needle 2 protrudes and punctures the skin M (see FIG. 5B).

  Next, when the urging by the spring is released, the puncture needle 2 is pulled out from the skin M by the restoring force of the flow path forming body 20 itself, and the puncture needle 2 is pulled out into the through hole 22. It is stored (see FIG. 5C). Then, blood B as a liquid sample discharged to the surface of skin M by puncture rises along the needle or along the inner wall surface of through-hole 22 (indicated by a thick arrow in FIG. 5C).

On the other hand, not only can the atmosphere flow from the outside of the flow path forming body 20 by opening or restoring the air passage 23 by the recovery of the flow path forming body 20, but also the air in the through hole 22 is exhausted as the blood B rises. (Indicated by a broken line arrow in FIG. 5C). The blood that has risen along the puncture needle 2 or the blood that has risen along the wall surface of the through hole 22 rises to the bottom surface 21a of the insertion portion, and then flows toward the groove 23a along the air flow. The flow of blood B passes through the reaction part inlet 3a and is accommodated in the reaction part 3 from the inlet 3a.
In addition, since the ventilation path 23 is a curved path, the flow of a liquid having a higher viscosity than air is prevented at the bent portion. Therefore, it can be expected that blood that has risen through the wall surface of the through hole 22 near the groove 23a is also prevented from flowing out from the air passage 23 and flows toward the reaction portion inlet 3a.

  As described above, in the needle-integrated sensor of the present embodiment, the discharged blood is effectively transferred to the reaction unit 3 even though the puncture needle 2 and the reaction unit entrance 3a are arranged at a separated position. Since it can be introduced, only the minimum blood required for the measurement need be drained. Therefore, the portion where the skin is pierced with the puncture needle can be shallow, and the pain of the subject can be reduced as compared with the conventional lancet type measurement device in which the puncture needle is driven separately from the sensor body. .

  In the above embodiment, the air passage 23 is formed by the groove 23a provided in the bottom surface 21a of the insertion portion and the communication hole 23b drilled in the peripheral wall portion that becomes the outer fitting portion of the sensor body in the flow path forming body 20. Although comprised, the ventilation path formed in a sensor main body attachment part is not limited to this. For example, instead of the groove 23a, a part of the bottom surface 21a of the insertion portion may be cut out to allow the through hole 22 and the communication hole 23b to communicate with each other, or air may pass through the bottom surface 21a of the insertion portion. You may only roughen as much as possible. Further, instead of the communication hole 23b, the clearance of the fitting portion may be increased so that the air passage provided on the fitting portion bottom surface 21a communicates with the outside of the flow path forming body. For example, in the flow path forming body 20 ′ used in the needle-integrated sensor shown in FIG. 6, air can pass through the fitting insertion portion bottom surface 21′a in the fitting insertion portion 21 ′ serving as the sensor body attachment portion. By providing a narrow groove and designing the insertion of the sensor body 10 into a loose fit state, an air passage that connects the through hole 22 and the outside of the flow path forming body 20 ′ is formed.

Further, in the embodiment shown in FIG. 1, the sensor body 10 and the flow path forming body 20 are fitted with substantially no clearance by notching the tip portion of the mounting portion 6 at the portion corresponding to the bent portion of the air passage 23. However, the notch of the mounting portion 6 is not essential in forming a bent air passage. On the other hand, the mounting portion 6 is cut out above the insertion portion 21 so that the groove 23a formed on the bottom surface 21a of the insertion portion and the cutout portion of the mounting portion 6 communicate with the outside of the flow path forming body 20. An air passage may be formed.

  Furthermore, in the embodiment shown in FIG. 1, the air hole 3 b is provided above the reaction unit 3. However, in the needle integrated sensor of the present invention, the liquid sample rising through the through-hole 22 is preferentially introduced into the reaction unit entrance. As long as it has the structure introduced into 3a, the air hole 3b may not be provided. As a configuration in which the liquid sample that has risen through the through hole 22 is preferentially introduced toward the reaction portion inlet 3a, a bent portion may be provided in the air passage so that the liquid does not flow easily even if air flows. In addition, a surfactant may be simply applied near the entrance of the reaction part.

  Moreover, in the said embodiment, although it was the fitting type flow path formation body attached by fitting to a sensor main body, the flow path formation body used by this invention is not limited to this. For example, as shown in FIG. 7, a cylindrical flow path forming body 25 having a through-hole 22 serving as a flow path provided in the center may be attached to the tip of the sensor body 10 by being fixed with an adhesive or the like. Good. In the flow path forming body 25, the air passage is a groove 26 extending in the radial direction on the sensor body mounting surface 25a.

  Furthermore, in the said embodiment, although the reaction part inlet_port | entrance communicated directly with the through-hole, you may communicate with the through-hole used as a flow path by arrange | positioning the reaction part inlet_port | entrance in the middle of a ventilation path. In this case, the liquid sample flowing through the ventilation path is more preferentially flowed from the reaction section inlet into the reaction section than flowing out of the flow path formation body after flowing in the ventilation path. At the entrance of the reaction part, a liquid outflow prevention mechanism such as a bent part is provided in the air passage part extending from the flow path to the outside of the flow path forming body, or the liquid sample is preferentially flowed into the reaction part rather than flowing through the air passage. A surfactant may be applied in the vicinity.

  In the needle-integrated sensor of the present invention, the position where the air passage is provided is not limited to the sensor body mounting portion. It is only necessary that the through hole serving as the flow path communicates with the outside of the flow path forming body. For example, even though the communication hole is formed by drilling the peripheral wall of the flow path forming body at a position in the middle of the through hole. Good.

  In addition, the air passage may be formed on the subject contact surface of the flow path forming body, and may be provided so that the through hole communicates with the outside of the flow path forming body in contact with the subject. . When a ventilation path is provided on the contact surface of the subject, it is preferable to include a liquid outflow prevention mechanism that prevents the liquid sample discharged on the subject surface from leaking out of the flow path formation body from the ventilation path. . In the above embodiment, by providing a bent portion in the middle of the air passage, the liquid is prevented from flowing out of the flow path forming body, but the protective wall for preventing the liquid outflow is a peripheral wall that forms a through hole. May be provided separately. Examples of the flow path forming body having such a configuration include a flow path forming body 30 having a double wall structure as shown in FIGS. 8 and 9.

  The flow path forming body 30 has a double wall structure of an inner wall 30 a constituting the through hole 22 that becomes a flow path and an outer wall 30 b that is a protective wall for liquid outflow and a peripheral wall of the flow path forming body 30. The surface of the inner wall 30a on the subject contact side is slightly lower than the surface of the outer wall 30b on the subject contact side, so that the flow path forming body 30 is simply placed on the subject (indicated by a one-dot chain line in FIG. 9). In this state, the surface on the subject contact side of the outer wall 30b becomes the subject contact surface, and a gap S is formed between the inner wall 30a and the subject. In a state where the notch 31 is notched in the subject contact surface of the outer wall 30b and the flow path forming body 30 is in contact with the subject, the notch 31 and the inner wall 30a and the subject contact surface are in contact with each other. The through-hole 22 communicates with the outside of the flow path forming body 30 through a gap S formed therebetween. That is, the air passage is constituted by the notch 31, the valley 30c between the inner wall 30a and the outer wall 30b, and the gap S formed between the inner wall 30a and the subject contact surface. In the needle integrated sensor provided with such a flow path forming body 30, the flow path forming body 30 is compressed by pressurization in the puncturing direction, and the tip of the puncture needle protrudes from the through hole 22 to pierce the skin. In such a state, the subject-side surface of the inner wall 30a is in contact with the subject, and the through hole 22 is in a substantially sealed state. By releasing the applied pressure, the flow path forming body 30 is restored, a gap S is formed between the inner wall 30a and the subject, and the through hole 22 and the air passage are in communication with each other. In such a state, air can flow in and out between the outside of the flow path forming body 30 and the through hole 22 through the ventilation path. The inflow of air from the subject contact surface can be expected to promote blood discharge when the puncture needle is pulled out from the subject by returning the flow path forming body 22 to atmospheric pressure. The blood discharged to the skin surface can be guided to the reaction portion inlet 3a through the inner peripheral surface of the inner wall 30a that is the peripheral wall of the puncture needle 2 and the through hole 22. At this time as well, it can be expected that blood will rise in the through hole 22 due to the inflow and outflow of air through the air passage, particularly the inflow of air from the subject contact surface. On the other hand, the blood discharged to the skin surface is prevented from flowing out of the flow path forming body 30 by the outer wall 30b. In the case where a vent path is provided on the subject contact surface side, not only a liquid outflow prevention mechanism is provided, but also a surfactant in the vicinity of the subject-side opening of the inner wall 30a that serves as the entrance to the through hole 22. May be applied so that the liquid sample preferentially flows into the through hole 22 rather than the trough 30c.

  In the needle-integrated sensor of the present invention, the number of air passages provided in the flow path forming body is not limited to one, and a plurality of different air paths can be used as long as the liquid sample discharged by puncture can be effectively stored in the reaction unit. An air passage may be provided. For example, in the flow path forming body 30, apart from the air flow path provided on the subject contact surface side, as shown in the embodiment of FIG.

  In the above embodiment, the flow path forming body is composed of an elastic body or a viscoelastic body, and the needle is pierced and pulled out by utilizing the deformation and restoration of the flow path forming body. The needle integrated sensor is not limited to this. You may comprise a flow-path formation body with a rigid body. In this case, in order to allow the puncture needle to appear and disappear from the flow path forming body, the measuring instrument to which the needle integrated sensor is attached has a drive mechanism for driving the needle integrated sensor body in the puncture direction and a drive mechanism for pulling back the needle. It may be provided.

  In the above embodiments, the puncture needle is attached to the outside of the reaction part. However, in the needle integrated sensor of the present invention, for example, as shown in FIG. 10, the puncture needle is attached to the reaction part 3 ′. It may be mounted and fixed inside. In the flow path forming body 20 ″ used in the needle integrated sensor shown in FIG. 10, the air passage 23 ′ is provided in the middle of the through hole 22.

  Furthermore, in the embodiment shown in FIG. 1, the electrode is provided on the insulating substrate to which the needle is not attached. However, in the needle integrated sensor of the present invention, the positional relationship between the needle attachment position and the electrode substrate is Not limited. Electrodes may be provided on the substrate on the needle mounting side, and it is not necessary that the positive electrode and the negative electrode are provided on the same substrate. One substrate may be provided with a positive electrode and the other substrate may be provided with a negative electrode. In addition, the detection unit has a configuration in which two substrates are bonded together. For example, as disclosed in International Publication No. 2005-010519, a pair of electrodes is arranged on one substrate, and the electrodes are on the inside. You may comprise by bending in this way. Moreover, the shape of the detection unit is not limited to a flat plate shape, and may be a cylindrical shape, and the reaction unit may be a cylindrical shape.

It is sectional drawing which shows the structure of the needle | hook integrated sensor of one Embodiment of this invention. It is the top view (a) and sectional drawing (b) which show an example of the detection part used for the needle | hook integrated sensor shown in FIG. It is a perspective view which shows the structure of the flow-path formation body used for the needle | hook integrated sensor of one Embodiment of this invention. It is the schematic which shows the structure of one Example of the measuring apparatus with which the needle | hook integrated sensor of this embodiment was mounted | worn. It is a figure for demonstrating the usage method of the needle | hook integrated sensor of this embodiment. It is sectional drawing which shows other embodiment of the needle | hook integrated sensor of this invention. It is sectional drawing which shows other embodiment of the needle | hook integrated sensor of this invention. It is a figure which shows other embodiment of the flow-path formation body used for the needle | hook integrated sensor of this invention. It is sectional drawing which shows the structure of the needle | hook integrated sensor which attached the flow-path formation body shown in FIG. It is sectional drawing which shows other embodiment of the needle | hook integrated sensor of invention. It is a figure which shows the structure of the conventional lancet integrated sensor.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Detection part 2 Puncture needle 3,3 'Reaction part 3a Reaction part entrance 10 Sensor main body 20,20', 20 ", 25,30 Flow path formation body 21,21 'Insertion part 22 Through-hole 23,23', 26 Airway

Claims (7)

Puncturing needle for discharging the liquid sample from the subject, wherein the reaction unit in which the liquid sample is accommodated, and Rutotomoni includes a detector for detecting the result of the reaction portion integrally, the puncture needle, the reaction section, And a needle-integrated sensor main body provided so that the detection unit is integrally movable ,
A needle integrated sensor provided with a flow path forming body in which a through hole serving as a flow path from the contact portion of the subject to the reaction section is provided, and the puncture needle is inserted into the through hole; There,
A needle-integrated sensor in which an air passage that communicates the through hole and the outside of the flow path forming body is provided in the flow path forming body. The said flow path formation body is comprised with the elastic body or viscoelastic body which changes the puncture direction length of the said through-hole by deformation | transformation, and enables the said puncture needle to protrude and retract from the said through-hole. Needle integrated sensor. The needle integrated sensor according to claim 1 or 2, wherein the air passage is provided in a mounting portion of the needle integrated sensor main body. The needle integrated sensor according to claim 3, wherein the air passage is provided so that the reaction portion entrance is located in the middle of the air passage or in the vicinity of the air passage entrance. The needle integrated sensor according to any one of claims 1 to 4, wherein a liquid outflow prevention mechanism is provided in the air passage. The needle integrated sensor according to claim 5, wherein the liquid outflow prevention mechanism is a bent portion provided in the middle of the air passage. The needle integrated sensor according to any one of claims 1 to 6, wherein a surfactant is applied at least in the vicinity of the entrance of the reaction part.

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