JP4949007B2 - Fundus image processing apparatus, fundus photographing apparatus, and program - Google Patents

Description

  The present invention relates to a fundus image processing apparatus that processes a fundus image, a fundus imaging apparatus that captures and displays a fundus image, and a program that controls a computer that processes the fundus image, and particularly displays an analysis result of the fundus image. It is about technology.

  Glaucoma is a disease in which the optic nerve is damaged for some reason and the visual field is lost, and is known as one of the main causes of blindness. In glaucoma, the optic disc is depressed due to an increase in intraocular pressure, which results in the loss of blood supply to the optic nerve cell and the death of the optic nerve cell, and a visual field defect without an increase in intraocular pressure. There is a thing. Even in the latter case (normal tension glaucoma), depression occurs in the optic nerve head.

  In view of such a phenomenon, as an index for diagnosing glaucoma, a C / D ratio reflecting the depressed state of the optic disc has been widely used. In recent years, the R / D ratio has also been used.

  C / D ratio (cup-to-disc ratio) is defined as the ratio of the diameter of the outer edge of the optic disc capped region to the diameter of the outer edge of the optic disc (disc). The The ratio of diameters in the vertical direction (body axis direction of the subject) is called a vertical C / D ratio, and the ratio of diameters in the horizontal direction (direction perpendicular to the body axis direction) is called a horizontal C / D ratio. Yes (see, for example, Patent Document 1).

  The R / D ratio (rim-to-disc ratio) is defined as the ratio of the width of the rim region to the measurement position of the width and the nipple diameter passing through the nipple center. Here, the rim region means a region existing between the outer edge of the optic nerve head and the outer edge of the depression of the optic nerve head. The R / D ratio can be defined for each radial line group passing through the nipple center.

  In recent years, various methods for analyzing a fundus image and obtaining a C / D ratio have been developed (see, for example, Patent Documents 1 to 3). In such a conventional invention, the measured value of the C / D ratio is displayed on the display as it is. As for the C / D ratio, since the vertical C / D ratio and the horizontal C / D ratio are generally referred to, there is no particular problem even if only the measured values are displayed.

JP-A-11-151206 JP 2006-263127 A JP 2006-280411 A

  As described above, according to the conventional method, the fundus image can be analyzed to obtain and display the C / D ratio, but the R / D ratio cannot be automatically measured. In addition, if the conventional method is followed, the measured value of the R / D ratio can only be displayed as it is, and therefore when the R / D ratio is measured for a large number of parts, the measurement result is displayed with good visibility. I can't. As a result, a doctor who has little diagnostic experience may have a problem that the diagnosis takes a long time or a problem that the diagnosis cannot be easily performed.

  The present invention has been made to solve the above problems, and provides a fundus image processing apparatus, fundus photographing apparatus, and program capable of displaying an index obtained by analyzing a fundus image with high visibility. The purpose is to do.

  In order to achieve the above object, the invention according to claim 1 analyzes the image data of the fundus image, and the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region, and the optic nerve. An analysis unit that obtains a plurality of R / D ratios by calculating a ratio with the outer edge diameter of the nipple region for each of a plurality of portions of the rim region, a display unit, and the fundus image are displayed on the display unit. A fundus image processing apparatus comprising: control means for displaying image information representing a distribution of R / D ratio values acquired by the analyzing means on the fundus image.

  The invention according to claim 2 is the fundus image processing apparatus according to claim 1, wherein the control means classifies the plurality of R / D ratio values into a range of 2 or more, The image information is displayed in a different display mode.

  The invention according to claim 3 is the fundus image processing apparatus according to claim 2, wherein the control means displays each of the classifications by color as the different display modes.

  The invention according to claim 4 is the fundus image processing apparatus according to claim 1, wherein the control means displays the image information at an outer edge position of the optic disc area in the fundus image. It is characterized by.

  The invention according to claim 5 is the fundus image processing apparatus according to claim 1, further comprising an operation unit, wherein the control unit is configured such that the position on the displayed fundus image is determined by the operation unit. When designated, an R / D ratio value corresponding to the designated position is displayed on the display means.

  The invention according to claim 6 is the fundus image processing apparatus according to claim 1, further comprising an operation unit, wherein the analysis unit causes the region on the displayed fundus image to be displayed by the operation unit. When designated, the average value of the R / D ratio in the designated area is calculated, and the control means displays the calculated average value of the R / D ratio on the display means. And

  The invention according to claim 7 analyzes image data of two fundus images acquired at different dates and times for the same fundus, and for each fundus image, the outer edge of the optic nerve head region and the outer edge of the recessed region A plurality of R / D ratios are obtained by calculating a ratio between the width of the rim region sandwiched between the rim region and the diameter of the outer edge of the optic disc region for each of a plurality of portions of the rim region, and for each fundus image Analyzing means for calculating each difference of the acquired R / D ratios, display means, and displaying at least one of the two fundus images on the display means, and calculating the analyzing means by the analyzing means A fundus image processing apparatus comprising: control means for displaying difference image information representing a distribution of a plurality of difference values on the at least one fundus image.

  The invention according to claim 8 is the fundus image processing apparatus according to claim 7, wherein the control means classifies the plurality of difference values into two or more ranges, and displays each classification differently. The difference image information is displayed as an aspect.

  The invention according to claim 9 is the fundus image processing apparatus according to claim 7, wherein the control means is configured to obtain the plurality of R acquired for one fundus image of the two fundus images. Information representing a part corresponding to an R / D ratio equal to or lower than a predetermined threshold in the / D ratio is displayed on the other fundus image.

  The invention according to claim 10 analyzes the image data of the fundus image, and the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region, and the diameter of the outer edge of the optic nerve head region. Represents a plurality of R / D ratio values acquired by the analysis means, the display means, and the analysis means for calculating a plurality of R / D ratios for a plurality of portions of the rim region, respectively. A fundus image processing apparatus comprising: control means for displaying graph information on the display means together with the fundus image.

  The invention according to claim 11 is the fundus image processing apparatus according to claim 10, wherein the control means displays the graph information in which each value of the plurality of R / D ratios is expressed by a histogram. It is displayed.

  The invention according to claim 12 is the fundus image processing apparatus according to claim 10, wherein the control means classifies the plurality of R / D ratio values into a range of 2 or more, and The graph information is displayed as a different display mode.

  The invention according to claim 13 is the fundus image processing apparatus according to claim 12, wherein the control means displays the respective classifications in different colors as the different display modes.

  The invention according to claim 14 is the fundus image processing apparatus according to claim 10, wherein the control means associates designated part information indicating a part of a fundus image designated in advance with the graph information. It is displayed on the display means.

  The invention according to claim 15 is the fundus image processing apparatus according to claim 10, wherein the control means associates the plurality of R / D ratio values with the graph information to the display means. It is displayed.

  The invention according to claim 16 is the fundus image processing apparatus according to claim 10, further comprising an operation unit, wherein the analysis unit uses the operation unit to display information in the displayed graph information. When designated, the average value of the R / D ratio corresponding to the designated information is calculated, and the control means displays the calculated average value of the R / D ratio on the display means. It is characterized by.

  The invention according to claim 17 analyzes the image data of two fundus images acquired at different dates and times for the same fundus, and for each fundus image, the outer edge of the optic disc area and the outer edge of the recessed area A plurality of R / D ratios are obtained by calculating a ratio between the width of the rim region sandwiched between the rim region and the diameter of the outer edge of the optic disc region for each of a plurality of portions of the rim region, and for each fundus image Analysis means for calculating the respective differences of the acquired R / D ratios, display means, and difference graph information representing the values of the plurality of differences calculated by the analysis means, the two fundus images A fundus image processing apparatus comprising: a control unit configured to display the display unit together with at least one of the display unit.

  The invention according to claim 18 is the fundus image processing apparatus according to claim 17, wherein the control means classifies the plurality of difference values into two or more ranges, and displays each classification differently. The difference graph information is displayed as an aspect.

  The invention according to claim 19 is the fundus image processing apparatus according to claim 17, wherein the control means is configured to obtain the plurality of R acquired for one fundus image of the two fundus images. Information representing a part corresponding to an R / D ratio equal to or lower than a predetermined threshold in the / D ratio is displayed on the other fundus image.

  The invention according to claim 20 analyzes the image data of the fundus image, and the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region, and the diameter of the outer edge of the optic nerve head region. Represents a plurality of R / D ratio values acquired by the analysis means, the display means, and the analysis means for calculating a plurality of R / D ratios for a plurality of portions of the rim region, respectively. Fundus image processing, comprising: control means for displaying graph information on the display unit together with the fundus image and displaying image information representing the distribution of the R / D ratio values on the fundus image. Device.

  The invention according to claim 21 is the fundus image processing apparatus according to claim 20, further comprising operation means, wherein the control means is arranged such that the position on the displayed fundus image is determined by the operation means. When designated, the display mode of information in the graph information corresponding to the designated position is changed.

  The invention according to claim 22 is the fundus image processing apparatus according to claim 20, further comprising an operation unit, wherein the control unit is configured such that information in the displayed graph information is obtained by the operation unit. When designated, position information representing a position on the fundus image corresponding to the designated information is displayed on the display means.

  The invention according to claim 23 is the fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17 or claim 20, wherein the control means is the optic disc region. A nipple outer edge image representing the outer edge position and a recessed outer edge image representing the outer edge of the recessed area are displayed on the fundus image.

  The invention according to claim 24 is the fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17 or claim 20, wherein the analysis means The image data is analyzed to determine the center position of the optic nerve head region, and the R / D ratios at a plurality of sites at a fixed angular interval centered on the center position are obtained.

  The invention according to claim 25 is the fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17 or claim 20, wherein the control means is the R / D. An image representing the width of the rim region used for calculating the ratio and an image representing the diameter of the outer edge of the optic nerve head region are displayed on the fundus image.

  The invention according to claim 26 is the fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17 or claim 20, wherein the control means displays the displayed information. A scale image representing a distance on the fundus image is displayed together with the fundus image.

  The invention according to claim 27 is the fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17 or claim 20, wherein the analysis means Analyzing the image data, calculating the area of the optic disc region and the area of the rim region, the control means calculates the calculated value of the area of the optic disc region and the value of the area of the rim region It is displayed on the display means.

  The invention according to claim 28 is the fundus image processing apparatus according to claim 27, wherein the analyzing means calculates a ratio between the calculated area of the rim area and the area of the optic disc area. The control means is configured to display the calculated value of the area ratio on the display means.

  The invention according to claim 29 is the fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17 or claim 20, wherein the analysis means Analyzing the image data, calculating the ratio of the outer edge diameter of the recessed area and the outer edge diameter of the optic nerve head area to obtain a C / D ratio, and the control means obtains the obtained C / D ratio. The D ratio value is displayed on the display means.

  The invention according to claim 30 is the fundus image processing apparatus according to claim 29, wherein the analysis means uses the maximum diameter of the outer edge of the recessed region as the C / D ratio, and the optic nerve. A ratio with the maximum diameter of the outer edge of the nipple region is calculated.

  The invention according to claim 31 is the fundus image processing apparatus according to claim 29, wherein the analysis means uses the maximum diameter of the outer edge of the recessed region as the C / D ratio, and the maximum A ratio with a diameter of the outer edge of the optic disc region passing through the diameter is calculated.

  The invention according to claim 32 is the fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17 or claim 20, wherein the analysis means Analyzing the image data, calculating the area of the optic nerve head area and the area of the recessed area, the control means, the calculated value of the area of the optic nerve head area and the value of the area of the recessed area Is displayed on the display means.

  The invention according to claim 33 is the fundus image processing apparatus according to claim 32, wherein the analyzing means calculates a ratio between the calculated area of the recessed area and the area of the optic disc area. And the control means causes the display means to display the calculated value of the area ratio.

  The invention according to claim 34 is the fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17 or claim 20, further comprising an operation means, wherein the analysis means Calculates the width of the rim area and the diameter of the outer edge of the optic disc area based on the outer edge of the optic disc area and the outer edge of the recessed area specified on the displayed fundus image by the operation means It is characterized by.

  The invention according to claim 35 is characterized in that the acquisition means for acquiring the image data of the fundus image by photographing the fundus, analyzing the image data of the acquired fundus image, the outer edge of the optic disc area and the recessed area Analyzing means for obtaining a plurality of R / D ratios by calculating a ratio of the width of the rim region sandwiched between the outer edge of the rim and the diameter of the outer edge of the optic papilla region for each of a plurality of portions of the rim region; Display means; and control means for causing the display means to display the fundus image and displaying image information representing a distribution of R / D ratio values acquired by the analysis means on the fundus image. Is a fundus imaging apparatus characterized by the above.

  According to a thirty-sixth aspect of the present invention, there is provided acquisition means for photographing the fundus and acquiring image data of the fundus image, and image data of two fundus images acquired at different dates and times for the same fundus by the acquisition means. For each fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region is determined for each fundus image. To calculate a plurality of R / D ratios, and to calculate a difference between each of the plurality of R / D ratios acquired for each fundus image, a display unit, and the two fundus oculi At least one of the images is displayed on the display unit, and difference image information representing a distribution of the plurality of difference values calculated by the analysis unit is displayed on the at least one fundus image. And control means that presents a fundus photographing apparatus, characterized in that it comprises a.

  The invention according to claim 37 is characterized in that the acquisition means for acquiring the image data of the fundus image by photographing the fundus, the image data of the acquired fundus image is analyzed, and the outer edge and the recessed area of the optic disc area Analyzing means for obtaining a plurality of R / D ratios by calculating a ratio of the width of the rim region sandwiched between the outer edge of the rim and the diameter of the outer edge of the optic papilla region for each of a plurality of portions of the rim region; A fundus imaging apparatus comprising: display means; and control means for displaying graph information representing a plurality of R / D ratio values acquired by the analysis means together with the fundus image on the display means. .

  The invention according to claim 38 is characterized in that image data of a fundus image obtained by photographing the fundus is acquired, and image data of two fundus images acquired at different dates and times for the same fundus by the acquisition unit. For each fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region is determined for each fundus image. And calculating a plurality of R / D ratios and calculating a difference between the plurality of R / D ratios acquired for each fundus image, a display unit, and the analysis unit. Control means for causing the display means to display difference graph information representing the calculated values of the plurality of differences together with at least one of the two fundus images. It is an imaging apparatus.

  Further, the invention according to claim 39 is an acquisition means for photographing the fundus to acquire image data of the fundus image, and analyzing the acquired image data of the fundus image to obtain an outer edge and a recessed region of the optic nerve head region. Analyzing means for obtaining a plurality of R / D ratios by calculating a ratio of the width of the rim region sandwiched between the outer edge of the rim and the diameter of the outer edge of the optic papilla region for each of a plurality of portions of the rim region; Graph information representing a plurality of R / D ratio values acquired by the display means and the analyzing means is displayed on the display means together with the fundus image, and image information representing the distribution of the R / D ratio values is displayed. And a control means for displaying on the fundus image.

  The invention according to claim 40 is provided with a display means for displaying a fundus image, and a computer for processing the image data of the fundus image analyzes the image data of the fundus image to detect the outer edge of the optic nerve head region and the depression. Analysis means for obtaining a plurality of R / D ratios by calculating a ratio between the width of the rim region sandwiched between the outer edges of the region and the diameter of the outer edge of the optic disc region for each of a plurality of portions of the rim region. Causing the display to display the fundus image on the display unit, and to function as a control unit that displays on the fundus image image information representing a distribution of R / D ratio values acquired by the analysis unit. It is a featured program.

  The invention according to claim 41 is provided with display means for displaying a fundus image, and the computer for processing the image data of the fundus image has image data of two fundus images acquired for the same fundus at different dates and times. For each fundus image, the ratio of the width of the rim area sandwiched between the outer edge of the optic nerve head area and the outer edge of the recessed area and the diameter of the outer edge of the optic nerve head area is determined as a plurality of rim areas. A plurality of R / D ratios are calculated by calculating each of the regions, and the two fundus images are caused to function as an analysis unit that calculates respective differences of the plurality of R / D ratios acquired for the respective fundus images. And displaying the difference image information representing the distribution of the plurality of difference values calculated by the analyzing means on the at least one eye. And control means for displaying on the image to work with a program, characterized in that.

  Further, the invention according to claim 42 is provided with display means for displaying a fundus image, and a computer for processing the image data of the fundus image analyzes the image data of the fundus image, and the outer edge of the optic nerve head region and the depression Analysis means for obtaining a plurality of R / D ratios by calculating a ratio between the width of the rim region sandwiched between the outer edges of the region and the diameter of the outer edge of the optic disc region for each of a plurality of portions of the rim region. A program that functions to function as a control unit that causes the display unit to display graph information representing a plurality of R / D ratio values acquired by the analysis unit together with the fundus image.

  The invention according to claim 43 is provided with display means for displaying a fundus image, and the computer for processing the image data of the fundus image has image data of two fundus images acquired for the same fundus at different dates and times. For each fundus image, the ratio of the width of the rim area sandwiched between the outer edge of the optic nerve head area and the outer edge of the recessed area and the diameter of the outer edge of the optic nerve head area is determined as a plurality of rim areas. Each region is calculated to obtain a plurality of R / D ratios, and functions as an analysis unit that calculates the difference between the plurality of R / D ratios acquired for each fundus image. The difference graph information representing the plurality of difference values is displayed on the display unit together with at least one of the two fundus images. Which is a program which is characterized.

  The invention according to claim 44 is provided with a display means for displaying a fundus image, and a computer for processing the image data of the fundus image analyzes the image data of the fundus image, and the outer edge of the optic nerve head region and the depression Analysis means for obtaining a plurality of R / D ratios by calculating a ratio between the width of the rim region sandwiched between the outer edges of the region and the diameter of the outer edge of the optic disc region for each of a plurality of portions of the rim region. And displaying the graph information representing the plurality of R / D ratio values acquired by the analyzing means on the display means together with the fundus image, and displaying the image information representing the distribution of the R / D ratio values. It is a program characterized by functioning as control means for displaying on a fundus image.

  According to the present invention, image data of a fundus image is analyzed to obtain a plurality of R / D ratios, the fundus image is displayed, and image information representing the distribution of R / D ratio values is displayed on the fundus image. Since it is configured to display, the operator can intuitively grasp the value of the R / D ratio. Thus, according to the present invention, it is possible to display the index (R / D ratio) obtained by analyzing the fundus image with high visibility.

  In addition, according to the present invention, image data of two fundus images acquired at different dates and times for the same fundus are respectively analyzed to obtain a plurality of R / D ratios for each fundus image. And calculating at least one of the two fundus images on the display means, and displaying difference image information representing a distribution of a plurality of difference values on the fundus image. Therefore, the operator can intuitively grasp the change in the R / D ratio. Thus, according to the present invention, it is possible to display an index (change in R / D ratio) obtained by analyzing a fundus image with high visibility.

  In addition, according to the present invention, a plurality of R / D ratios are acquired by analyzing image data of the fundus image, and graph information representing the values of the plurality of R / D ratios is displayed together with the fundus image. Therefore, the operator can intuitively grasp the value of the R / D ratio. Thus, according to the present invention, it is possible to display the index (R / D ratio) obtained by analyzing the fundus image with high visibility.

  In addition, according to the present invention, image data of two fundus images acquired at different dates and times for the same fundus are respectively analyzed to obtain a plurality of R / D ratios for each fundus image. The difference graph information representing the plurality of difference values is displayed together with at least one of the two fundus images, so that the operator can calculate the difference between the R / D ratios. The change in ratio can be grasped intuitively. Thus, according to the present invention, it is possible to display an index (change in R / D ratio) obtained by analyzing a fundus image with high visibility.

  According to the present invention, the image data of the fundus image is analyzed to obtain a plurality of R / D ratios, and the graph information representing the values of the plurality of R / D ratios is displayed together with the fundus image. Since the image information representing the distribution of the R / D ratio value is displayed on the fundus image, the operator intuitively grasps the R / D ratio value from both the graph information and the image information. be able to. Thus, according to the present invention, it is possible to display the index (R / D ratio) obtained by analyzing the fundus image with high visibility.

  An example of a preferred embodiment of a fundus image processing apparatus, a fundus imaging apparatus, and a program according to the present invention will be described in detail with reference to the drawings.

<First Embodiment>
A first embodiment of the present invention will be described. In this embodiment, image data of a fundus image is analyzed to obtain an R / D ratio for a plurality of parts, and image information representing a distribution of values of the plurality of R / D ratios is displayed on the fundus image. By displaying the graph information representing the value of the R / D ratio, intuitive distribution of the R / D ratio distribution in the eye to be examined is promoted. Hereinafter, an example of an embodiment for realizing such a function will be described.

[Constitution]
An example of the configuration of the fundus image processing apparatus according to this embodiment is shown in FIGS. The fundus image processing apparatus 1 is connected to the ophthalmologic image database 2000 via a communication line such as a LAN (Local Area Network).

  The ophthalmic image database 2000 is a filing system that manages image data of images in the ophthalmic field. For example, a large-capacity storage device that stores digital image data and database software that manages data stored in the large-capacity storage device Including. The ophthalmic image database 2000 may include a filing system for other purposes such as an electronic medical record, in addition to a filing system for image data.

  Image data stored in the ophthalmic image database 2000 is acquired by the fundus imaging apparatus 1000. Although only one fundus photographing apparatus is shown in FIG. 1, it is possible to install two or more fundus photographing apparatuses.

  The fundus imaging apparatus 1000 is an apparatus that can acquire image data (digital data) G by capturing a fundus image of the eye to be examined. Image data G of the fundus image acquired by the fundus imaging apparatus 1000 is transmitted to and stored in the ophthalmic image database 2000 via a communication line such as a LAN. As the fundus imaging apparatus 1000, for example, any apparatus such as a fundus camera, an optical coherence tomography apparatus, or a scanning laser ophthalmoscope can be applied.

  The fundus camera is a device that irradiates illumination light toward the fundus, receives the fundus reflection light by a light receiving element such as a CCD (Charge Coupled Devices) image sensor, and acquires image data G of a fundus image. It is also possible to use a stereoscopic fundus camera (for example, refer to Japanese Patent Laid-Open No. 5-15499: referred to as a stereoscopic fundus camera) having left and right independent optical systems.

  An optical coherence tomography (OCT) device divides low-coherence light into two parts, irradiates one of the fundus, makes the backscattered light interfere with the other light, and receives it with a CCD image sensor or the like. It is an apparatus which acquires the image data G of this. As the optical coherence tomography apparatus, an apparatus of an arbitrary system such as a Fourier domain (also referred to as a frequency domain) system, a time domain (time domain) system, or a swept source system (swept source) system can be used ( For example, refer to JP 2006-184284 A).

  A scanning laser opthalmoscope (SLO) scans a light beam to irradiate the fundus and receives reflected light or fluorescence at a predetermined portion with a CCD or the like to acquire image data G of the fundus image. Device (see, for example, JP-A-11-197109).

  The image data G of the fundus image is associated with information such as patient information such as the patient ID and patient name of the patient to be imaged, the imaging date and time, the imaging magnification, and various imaging conditions such as left and right eyes, and is stored in the ophthalmic image database 2000. Saved. The operator of the fundus image processing apparatus 1 can read and observe a desired fundus image of a desired patient by designating a patient ID, a patient name, and the like.

  When the fundus image is a monochrome image, the image data G of the fundus image is data in which the coordinate value of the pixel forming the fundus image is associated with the luminance value of each pixel. When the fundus image is a color image, the image data G is data in which the coordinate values of the pixels forming the fundus image are associated with the RGB values (R value, G value, B value) of each pixel.

  Note that the fundus image processing apparatus according to the present invention is not limited to the configuration for reading the captured image stored in the ophthalmic image database 2000. For example, the fundus image processing apparatus directly receives an image captured by the fundus image capturing apparatus 1000. There may be. In addition, the fundus image processing apparatus according to the present invention may include a drive device that reads image data G recorded on a medium (recording medium) such as a CD-R or a DVD-R.

  Further, the image data G of the fundus image is image data of a (pseudo) three-dimensional fundus image generated based on the luminance value of the image data of the fundus image as described in Japanese Patent Application No. 2005-217876. There may be. The image data of the three-dimensional fundus image may be generated by the fundus photographing apparatus 1000 or may be generated by the fundus image processing apparatus 1.

[Hardware configuration]
First, the hardware configuration of the fundus image processing apparatus 1 according to this embodiment will be described. The fundus image processing apparatus 1 includes, for example, a general-purpose computer. As shown in FIG. 2, the fundus image processing apparatus 1 includes a microprocessor 200, a RAM 201, a nonvolatile storage device 202, a display 203, a keyboard 204, a mouse 205, and a communication interface (I / F) 206. .

  The microprocessor 200 is configured by an arbitrary microprocessor such as a CPU (Central Processing Unit) or an MPU (Micro Processing Unit) that executes various arithmetic processes and control processes.

  A RAM (Random Access Memory) 201 is a volatile storage device, and a program and data being executed by the microprocessor 200 are expanded.

  The nonvolatile storage device 202 includes a storage device (external storage device) such as a hard disk drive (Hard Disk Drive) or a ROM (Read Only Memory). The non-volatile storage device 202 stores a program P in advance. The microprocessor 200 executes processing characteristic of this embodiment by developing the program P on the RAM 201. In addition, image data G of the fundus image received from the ophthalmologic image database 2000 is stored in the nonvolatile storage device 202 (particularly, a hard disk drive). The program P corresponds to an example of the “program” of the present invention.

  When the computer constituting the fundus image processing apparatus 1 constitutes a client of a client-server system, the program P is stored in the server, and the process is executed by appropriately calling it. May be.

  In addition, the fundus image processing apparatus 1 includes a display 203, a keyboard 204, and a mouse 205 as in a normal computer.

  The display 203 includes an arbitrary display device such as an LCD (Liquid Crystal Display) or a CRT (Cathode Ray Tube) display. The display 203 constitutes the display unit 141 shown in FIG. The display unit 141 corresponds to an example of the “display unit” of the present invention.

  The keyboard 204 and the mouse 205 are used as input devices for inputting various types of information based on information such as images and screens displayed on the display 203, and as operation devices for instructing execution of a desired operation. Used. The keyboard 204 and the mouse 205 constitute the operation unit 142 shown in FIG. Note that the operation unit 142 is not limited to a keyboard and a mouse, and may include a trackball, a joystick, a dedicated control panel, and the like. The operation unit 142 corresponds to an example of the “operation means” of the present invention.

  The communication interface 206 performs data communication with other devices such as the ophthalmic image database 2000 via a communication line such as a LAN. The communication interface 206 includes a network adapter such as a LAN card, for example. Further, in the case where connection to a WAN (Wide Area Network) such as the Internet is possible, a communication device such as a modem for the connection is provided in the communication interface 206.

[Control system configuration]
Next, the configuration of the control system of the fundus image processing apparatus 1 will be described with reference to FIG. The fundus image processing apparatus 1 includes a control unit 10, an image reception unit 11, an image storage unit 12, an image analysis unit 13, and a user interface 14.

(Control part)
The control unit 10 functions as the center of the control system of the fundus image processing apparatus 1. The control unit 10 includes a microprocessor 200 that operates based on the program P. The control unit 10 performs operation control of each unit of the fundus image processing apparatus 1 and various arithmetic processes. Details of these processes will be described later. The control unit 10 functions as an example of the “control unit” of the present invention.

  The control unit 10 is provided with a position specifying unit 101 and a display control unit 102. The position specifying unit 101 associates the position on the fundus image with the position of the information in the R / D ratio graph information described above. That is, when the position on the fundus image is designated, the position specifying unit 101 specifies information in the graph information corresponding to the designated position. Further, when information in the graph information is designated, a position on the fundus image corresponding to the designated information is specified.

  The display control unit 102 displays various display screens, fundus images, and information on the display unit 141 (display 203). In particular, the display control unit 102 performs processing such as changing the display mode of the position specified by the position specifying unit 101. The specific processing contents of the position specifying unit 101 and the display control unit 102 will be described later.

(Image reception department)
For example, the image receiving unit 11 transmits information such as a patient ID specified by an operator of the fundus image processing apparatus 1 and a photographing date and time to the ophthalmic image database 2000, and the fundus transmitted from the ophthalmic image database 2000 based on this information. The image data G of the image is received and input to the control unit 10. The control unit 10 causes the image storage unit 12 to store the image data G input from the image receiving unit 11. The image receiving unit 11 includes a communication interface 206.

  As described above, when the image data G is received directly from the fundus imaging apparatus 1000, the image reception unit 11 includes a connection interface with the fundus imaging apparatus 1000.

(Image storage unit)
The image storage unit 12 stores image data G of a fundus image, and includes a nonvolatile storage device 202 (particularly a hard disk drive). The control unit 10 performs a process of writing the image data G to the image storage unit 12 and a process of reading the image data G stored in the image storage unit 12.

(Image Analysis Department)
The image analysis unit 13 performs various types of analysis processing based on the image data G of the fundus image, and includes a microprocessor 200 and the like. The image analysis unit 13 corresponds to an example of “analysis means” of the present invention. The image analysis unit 13 includes an R / D ratio calculation unit 131, an average value calculation unit 132, a C / D ratio calculation unit 133, an area calculation unit 134, and an area ratio calculation unit 135. Hereinafter, each of these units 131 to 135 will be described.

(R / D ratio calculator)
The R / D ratio calculation unit 131 analyzes the image data G of the fundus image and obtains the value of the R / D ratio. The processing of the R / D ratio calculation unit 131 will be described more specifically. In order to calculate the R / D ratio, as described above, the outer edge of the region corresponding to the optic nerve head (optic nerve head region) in the fundus image and the region corresponding to the rim (rim region) are determined. There is a need. Note that the rim region is defined as a region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region, so that the outer edge of the optic nerve region and the outer edge of the recessed region need to be determined. A method for determining these conditions will be described later.

  Reference is now made to FIG. FIG. 3 shows an example of a fundus image based on the image data G (also represented by the symbol G). Symbol D indicates the outer edge of the optic disc region, and symbol C indicates the outer edge of the recessed region. The symbol O indicates the center position of the optic disc area. The center position O is defined as the center position of the circle, the center position of the ellipse (intersection position of the major axis and the minor axis), and the center of gravity position, respectively, when the outer edge of the optic disc area is circular, elliptical, or otherwise. can do.

  The R / D ratio calculation unit 131 sets a measurement site on a straight line passing through the center position O at a predetermined angular interval. As an example, the R / D ratio calculation unit 131 sets 72 measurement sites at intervals of 5 degrees: for example, the left side of the fundus image G is 0 degrees, 0 degrees clockwise, 5 degrees, 10 degrees,. -The direction of 345 degrees, 350 degrees, and 355 degrees is set as the measurement site. Each measurement site is set to i = 1 to 72.

  Next, the R / D ratio calculation unit 131 obtains the rim region width φR (i) and the outer edge D diameter (optic nerve head diameter) φD (i) of each measurement site i. A specific example of this process will be described. As a first example, φR (i) can be calculated by acquiring the number of pixels lined up in the width direction of the rim region and multiplying this number by a distance per pixel (known). As a second example, when a distance (metric) is set on the fundus image G in advance, the width of the rim region can be obtained using this metric. The optic nerve head diameter φD (i) can be similarly calculated.

  Subsequently, for each measurement site i, the R / D ratio calculation unit 131 calculates the R / D ratio by dividing the rim region width φR (i) by the optic disc diameter φD (i): measurement site i R / D ratio R / D (i) = φR (i) / φD (i). Thereby, a plurality of (here 72) R / D ratio values are obtained.

(Average value calculator)
The average value calculation unit 132 calculates an average value of two or more values among the values of the plurality of R / D ratios R / D (i) obtained by the R / D ratio calculation unit 131. The average value to be calculated is, for example, the average value of the R / D ratio in the measurement region (i = 13 to 25) included in the range corresponding to 11:00 to 1 o'clock in the optic disc area, or 5 to 7 o'clock. An area that is important in diagnosis using the R / D ratio, such as an average value of the R / D ratio in the measurement region (i = 49 to 61) included in the corresponding range, is calculated. Further, an average value may be calculated for the measurement site included in the range manually designated by the operator of the fundus image processing apparatus 1.

(C / D ratio calculator)
The C / D ratio calculation unit 133 analyzes the image data G of the fundus image and obtains a C / D ratio value. The processing of the C / D ratio calculation unit 133 will be described more specifically. In order to calculate the C / D ratio, as described above, it is necessary to determine the outer edge of the optic disc area and the outer edge of the recessed area in the fundus image. A method for determining these conditions will be described later.

  Reference is now made to FIGS. First, the first calculation method of the C / D ratio will be described with reference to FIG. In this first calculation method, the maximum diameter ΨC (v) of the outer edge C of the recessed area and the maximum diameter ΨD (v) of the outer edge D of the optic nerve head area are obtained, and these ratios are defined as the C / D ratio. C / D (v1) = ΨC (v) / ΨD (v). Here, each maximum diameter ΨC (v) and ΨD (v) represents the maximum diameter in the vertical direction. The maximum diameter ΨD (v) passes through the center position O of the outer edge D of the optic nerve head region (when the shape of the outer edge is a circle, an ellipse, or left-right symmetry).

  Next, the second calculation method of the C / D ratio will be described with reference to FIG. In this second calculation method, the maximum diameter ΨC (v) of the outer edge C of the recessed area and the diameter ΩD (v) of the outer edge D of the optic papilla area passing through the measurement site of the maximum diameter ΨC (v) are calculated. C / D (v2) = ΨC (v) / ΩD (v) which is obtained and defined as the C / D ratio. Here, the maximum diameter ΨC (v) and the diameter ΩD (v) represent the diameter in the vertical direction. The maximum diameter ΩD (v) generally does not pass through the center position O of the outer edge D of the optic nerve head region.

  In the above, the C / D value in the vertical direction (that is, the vertical C / D ratio) C / D (v1) and C / D (v2) are defined, but the C / D ratio in the horizontal direction (that is, the horizontal direction) C / D ratio) can be defined similarly: C / D (h1) = ΨC (h) / ΨD (h); C / D (h2) = ΨC (h) / ΩD (h).

(Area calculation part)
The area calculation unit 134 analyzes the image data G of the fundus image and calculates the area S (D) of the optic disc area and the area S (R) of the rim area. Further, the area calculation unit 134 calculates the area S (C) of the recessed area. Here, the area S (D) of the optic nerve head region is the area of the region surrounded by the outer edge D of the optic nerve head region. Further, the area S (C) of the recessed area is an area of the area surrounded by the outer edge C of the recessed area. Further, the area S (R) of the rim region is an area obtained by subtracting the area S (C) of the recessed region from the area S (D) of the optic nerve head: S (R) = S (D) − S (C).

  A specific example of a method for calculating the areas S (D), S (C), and S (R) will be described. As a first calculation method, there is a method using Green's theorem. Green's theorem is a widely used formula for determining the area of a region surrounded by a closed curve. As a second calculation method, the area can be obtained by counting the number of pixels included in the area measurement target region and multiplying this number of pixels by the area per pixel (assumed to be known).

(Area ratio calculator)
The area ratio calculation unit 135 calculates a predetermined area ratio based on the areas S (D), S (C), and S (R) obtained by the area calculation unit 134. The area ratio to be calculated is, for example, the area ratio (R / D area ratio) S (R / D) = S (R) / S (D) between the rim area and the optic nerve head area, and the recessed area and the optic nerve. Area ratio with the nipple region (C / D area ratio) S (C / D) = S (C) / S (D).

(User interface)
The user interface 14 is a user interface (User Interface) of the fundus image processing apparatus 1. The user interface 14 is provided with the display unit 141 and the operation unit 142 described above. In this embodiment, the display means and the operation means are configured separately, but a user interface such as a touch panel display in which these are integrated can also be applied.

[Usage form]
A usage pattern of the fundus image processing apparatus 1 having the above configuration will be described. The flowchart shown in FIG. 6 represents an example of the usage pattern of the fundus image processing apparatus 1. 7 to 14 show examples of display screens displayed in this usage pattern. The display control unit 102 performs display processing of these display screens.

(Step 1: Patient selection)
First, the operator performs a predetermined operation to display the menu screen 3000 shown in FIG. When the mouse 205 is operated and the patient button 3001 is clicked, a patient list screen 3100 shown in FIG. 8 is displayed. A patient list display unit 3101 of the patient list screen 3100 displays a list of patient IDs. The operator operates the scroll bar, the previous button 3102, the next button 3103, and the like with the mouse 205, and clicks and selects a desired patient ID. Then, by clicking the patient selection button 3104, the selected patient (ID) is confirmed.

(Step 2: Selection of fundus image)
When a patient is selected, the display control unit 102 displays a list of fundus images acquired for the patient in the past (fundus image list screen; not shown). Examples of the fundus image list screen include those that display thumbnail images such as thumbnails of the fundus image side by side, those that display a list of fundus image shooting dates, and those that sequentially display the fundus image in a slide show format. Any display form capable of selecting an image can be adopted. In addition to the fundus image, various types of information attached to the fundus image, such as the examination date and time and the right and left eyes can be displayed together.

  The operator operates the operation unit 142 to select a desired fundus image. When the fundus image is selected, the operator clicks the 3D button 3002 on the menu screen 3000 in FIG. 7, for example. The 3D button 3002 is operated when observing a fundus image captured by a stereoscopic fundus camera. Hereinafter, a case where image data G of a fundus image captured by a stereoscopic fundus camera is used will be described. In addition, when using the image data obtained by the other fundus imaging apparatus 1000, the same processing can be performed except that there is a pair of left and right image data G.

(Step 3: Setting the optical value of the eyeball)
When the fundus image is selected, an eyeball optical value setting screen 3200 shown in FIG. 9 is displayed. The correction mode setting unit 3201 displays a list for selecting an eyeball optical correction mode. Here, a mode using the eyeball optical value of the model eye (Mode 1), a mode using the eyeball optical value of the eye to be examined (Mode 2), and a mode using only the refractive power of the eye to be examined are displayed. Yes. The operator operates the mouse 205 to select a desired mode.

  When the mode using the eyeball optical value of the model eye is selected, the eyeball optical value of the model eye stored in advance is automatically set. The eyeball optical values set here are, for example, standard values of the Gullstrand model eye: refractive power = 0 (D), radius of curvature of cornea = 7.7 (mm), axial length = 2.38 (mm) .

  When a mode using the eyeball optical value of the eye to be examined is selected, an eyeball optical value input unit 3202 shown in FIG. 9 is displayed on the eyeball optical value setting screen 3200. The eyeball optical value input unit 3202 inputs an input space for inputting refractive power, a check box for selecting the presence or absence of a correction lens, an input space for inputting the radius of curvature of the cornea, and an axial length. Input space. The operator operates the keyboard 204 and the mouse 205 to input these values.

  When a mode using only the refractive power of the eye to be examined is selected, an eyeball optical value input unit 3202 shown in FIG. 10 is displayed in the eyeball optical value setting screen 3200. In the eyeball optical value input unit 3202, the input space for the radius of curvature and the input space for the axial length are invalid (that is, a state in which no input is accepted). The operator operates the keyboard 204 and the mouse 205 to input refractive power and select the presence / absence of a correction lens.

  The operator clicks an OK button 3203 shown in FIGS. 9 and 10 to determine the eyeball optical value to be used. When the OK button 3203 is clicked, the eyeball optical value at that time is set as a correction value.

  When a mode using the eyeball optical value of the eye to be examined or a mode using only refractive power is selected, when the OK button 3203 is clicked without inputting a necessary value, the display control unit 102 Pop up a dialog with a message instructing you to enter a value. Thereby, a necessary value can be surely input, and in some cases, a mode can be changed.

(Step 4: Alignment of left and right fundus images)
When the setting of the eyeball optical value is completed, the left and right fundus images of the three-dimensional fundus image are aligned. This step 4 is necessary only when a three-dimensional fundus image is used.

  When the setting of the eyeball optical system is completed, a fundus image alignment screen 3300 shown in FIG. 11 is displayed. The fundus image alignment screen 3300 is a screen for aligning the left and right fundus images of the three-dimensional fundus image.

  On the fundus image alignment screen 3300, a fundus image GL photographed by the left optical system of the stereoscopic fundus camera and a fundus image GR photographed by the right optical system are displayed side by side. The operator inputs alignment frames FL and FR to the left and right fundus images GL and GR, respectively. The positions and sizes of the frames FL and FR are adjusted by dragging the mouse 205, for example.

  Note that the frames FL and FR are set so as to include regions corresponding to the optic nerve head in the fundus images GL and GR, respectively. When the setting of the frames FL and FR is completed, the operator clicks an OK button 3301 to determine the frames FL and FR.

(Step 5: Designation of optic disc area)
When the OK button 3301 is clicked, the display control unit 102 extracts the image areas surrounded by the frames FL and FR from the left and right fundus images GL and GR, respectively. Image regions extracted from the left and right fundus images GL and GR are also represented by the fundus images GL and GR.

  The display control unit 102 displays the extracted left and right fundus images GL and GR on the display unit 141 in a stereoscopically viewable manner. For example, the following stereoscopic display modes are available.

  First, there is a method in which an operator puts on glasses for stereoscopic viewing and alternately displays the left and right fundus images GL and GR at predetermined time intervals. The stereoscopic glasses operate so as to alternately shield the left and right visual fields of the operator at predetermined time intervals. This shielding operation can be realized by, for example, a configuration using polarized light or a configuration using a liquid crystal shutter. The switching interval between the left and right fundus images GL and GR and the switching interval between the left and right visual field shields are the same (synchronized). That is, when the left fundus image GL is displayed on the display unit 141, the right visual field is blocked, and when the right fundus image GR is displayed, the left visual field is blocked. Note that the left and right switching intervals are set to be sufficiently short. As a result, the operator visually recognizes the left fundus image GL with only the left eye and visually recognizes the right fundus image GR with only the right eye, and the left and right can be switched at a sufficiently high speed. The fundus can be grasped in three dimensions.

  It is also possible to use a general-purpose display that displays an image in a stereoscopic manner.

  If necessary, the operator moves the display positions of the fundus images GL and GR so that the image area corresponding to the optic nerve head is located near the center of the screen, for example, by dragging the mouse 205.

  Thus, in a state where the fundus images GL and GR are stereoscopically viewed, the operator operates the operation unit 142 to designate the optic disc area. A symbol D in the fundus image display screen 3400 shown in FIG. 12 represents the optic disc region (outer edge) designated on the stereoscopic fundus image GLR.

  A specific example of the designation mode of the optic nerve head region D will be described. The operator finds a position corresponding to the outer edge of the optic disc while observing the fundus image GLR, and inputs a plurality of points by clicking the mouse 205 on the position. The control unit 10 calculates an ellipse equation that passes through a plurality of input points or positions in the vicinity thereof. The display control unit 102 displays the ellipse on the fundus image GLR (for example, on each fundus image GL, GR). The optic disc area D of FIG. 12 shows this ellipse.

  In addition, the designation | designated aspect of the optic disc area | region D is not limited to this. For example, a closed curve passing through a plurality of points input on a position corresponding to the outer edge of the optic disc may be obtained and displayed. The closed curve may be a curve that can be differentiated at an arbitrary position, or may be a curve that cannot be differentiated at a certain position. Specifically, a spline curve, a Bezier curve, or the like can be used.

(Step 6: Specifying the recessed area)
When the designation of the optic disc area D is completed, the operator designates a recessed area in the optic disc area D. Designation of the recessed area can be performed by the same operation as in the optic nerve head area D.

  The recessed area C shown in FIG. 12 is represented by a smooth closed curve passing through a plurality of points input by the operator, unlike the optic disc area D approximated by an ellipse. Although an approximate ellipse can be used for the recessed area, the method shown in FIG. 12 is considered desirable in order to more accurately reflect the shape of the recessed area.

  Note that a two-dimensional coordinate system (xy coordinate system) is set in advance for the fundus image GLR (fundus images GL, GR). The control unit 10 acquires the coordinate value of the optic disc area D specified in step 5 and the coordinate value of the recessed area C specified in step 6.

(Step 7: Calculation of C / D ratio)
When the optic disc area D and the recessed area C are designated in the fundus image GLR, the C / D ratio calculation unit 133 of the image analysis unit 13 performs the vertical C / D ratio C / D (v1) as described above. , C / D (v2) and horizontal C / D ratios C / D (h1) and C / D (h2) are calculated, respectively.

(Step 8: Calculation of R / D ratio)
Further, the R / D ratio calculation unit 131 of the image analysis unit 13 calculates a plurality of R / D ratios R / D (i) (for example, 72 at intervals of 5 degrees) as described above.

  In addition, the average value calculation unit 132 includes an average value of R / D ratios in a measurement part included in a range corresponding to 5:00 to 7:00 in the optic nerve head region D and a measurement part included in a range corresponding to 11:00 to 1:00. The average value of the R / D ratio at is calculated.

(Step 9: Calculation of area and area ratio)
In addition, the area calculating unit 134 of the image analyzing unit 13 calculates the area S (D) of the optic nerve head region, the area S (C) of the recessed region, and the area S (R) of the rim region as described above.

  Further, the area ratio calculation unit 135 calculates the C / D area ratio S (C / D) and R / D based on these areas S (D), S (C), and S (R) as described above. The area ratio S (R / D) is calculated.

(Step 10: Display of measurement results)
The display control unit 102 calculates C / D (v1), C / D (v2), C / D (h1), and C / D (h2) calculated in step 7 and R calculated in step 8. / D (i) and the areas S (D), S (C), S (R) and area ratios S (C / D), S (R / D) calculated in step 10 are displayed.

  A measurement result display screen 3500 shown in FIG. 13 represents an example of a screen that displays these values together with the fundus oculi image GLR. At the bottom of the measurement result display screen 3500, a plurality of operation buttons 3530 for performing various processes are provided. The operator can perform a desired operation by selectively clicking a desired operation button.

  The symbol D (i) in the measurement result display screen 3500 represents the optic disc diameter for a certain i (for example, i = 1 to 72), and the symbol R (i) represents the width of the rim region at this i. Yes. The length of the optic disc diameter D (i) corresponds to the aforementioned optic disc diameter φD (i) (see FIG. 3). The length of the rim region width R (i) corresponds to the rim region width φR (i) described above. Therefore, the ratio of the length of the rim region width R (i) to the length of the optic disc diameter D (i) corresponds to the R / D ratio R / D (i) at i.

  Symbol C (v) represents the maximum diameter of the recessed region C in the vertical direction, and symbol D (V) represents the maximum diameter of the optic disc region D in the vertical direction. The length of the maximum diameter C (v) in the vertical direction of the recessed area C corresponds to the maximum diameter (outer edge) ΨC (v) of the recessed area (see FIG. 4). The length of the maximum diameter D (V) in the vertical direction of the optic nerve head region D corresponds to the maximum diameter (outer edge) ΨD (v) of the aforementioned optic nerve head region. Therefore, the ratio between the length of the maximum diameter C (v) of the recessed area C and the length of the maximum diameter D (V) of the optic nerve head area D is the first C / D ratio C / D (v1) in the vertical direction. ).

  Further, the symbol D (v) represents the vertical diameter of the optic papilla region D passing through the maximum vertical diameter C (v) of the recessed region C. The length of the diameter D (v) corresponds to the (outer edge) diameter ΩD (v) of the optic nerve region described above. Therefore, the ratio between the length of the maximum diameter C (v) of the recessed area C and the length of the diameter D (v) of the optic nerve head area D is the second C / D ratio C / D (v2) in the vertical direction. It corresponds to.

  Symbol C (h) represents the maximum diameter of the recessed region C in the horizontal direction, and symbol D (H) represents the maximum diameter of the optic nerve head region D in the horizontal direction. The length of the maximum horizontal diameter C (h) of the recessed region C corresponds to the maximum diameter (outer edge) ψC (h) of the recessed region described above. Further, the length of the horizontal maximum diameter D (H) of the optic nerve head region D corresponds to the maximum diameter (outer edge) ΨD (h) of the above-mentioned optic nerve head region. Therefore, the ratio between the length of the maximum diameter C (h) of the recessed area C and the length of the maximum diameter D (H) of the optic nerve head area D is the first C / D ratio C / D (h1) in the horizontal direction. ).

  Further, the symbol D (h) represents the horizontal diameter of the optic papilla region D that passes through the maximum horizontal diameter C (h) of the recessed region C. The length of the diameter D (h) corresponds to the (outer edge) diameter ΩD (h) of the optic milk region described above. Therefore, the ratio between the length of the maximum diameter C (h) of the recessed region C and the length of the diameter D (h) of the optic disc region D is the second horizontal C / D ratio C / D (h2). It corresponds to.

  On the fundus image GLR of the measurement result display screen 3500, an image representing the outer edge D of the optic nerve head region (papillary outer edge image) and an image representing the outer edge C of the recessed region (recessed outer edge image), as well as the width R of the rim region. An image representing (i) and at least one of diameters D (i), D (v), D (V), D (h), D (H), C (v), and C (h) An image to be represented (linear image) or the like is displayed.

  The measurement value display unit 3510 of the measurement result display screen 3500 displays the eyeball optical value input in step 3, the measurement value calculated in the calculation processing in steps 7 to 9, and the like. More specifically, the measurement value display unit 3510 displays the following information: refractive power of the subject eye (Refractive Error [D]), average corneal curvature (Mean Corne Curve [mm]), Axial length (Axial Length [mm]), area of optic disc area D (Disc Area [mm2]), area of recessed area C (Cup Area [mm2]), area of rim area (Rim Area [mm2]) , The area ratio between the recessed area C and the optic nerve head area D (C / D Area Ratio), the area ratio between the rim area and the optic nerve head area D (R / D Area Ratio), the first vertical C / D ratio ( Vertical C / D Ratio 1), second vertical C / D ratio (Vertical C / D Ratio 2), first water Flat C / D ratio (Horizontal C / D Ratio 1), second horizontal C / D ratio (Horizontal C / D Ratio 2).

  In addition, in the “R / D Ratio” column of the measurement value display unit 3510, any one of the plurality of R / D ratios R / D (i) calculated in step S8 is displayed. An example of the display mode of the R / D value will be described. First, the operator designates a desired position in the optic disc region D by clicking the mouse 205 or the like. The position specifying unit 101 of the control unit 10 specifies the measurement position (angle) of the R / D ratio that is closest to the designated position. The display control unit 102 displays an image (linear image) indicating the specified measurement position on the fundus image GLR. Further, the display control unit 102 acquires the measurement result R / D (i) of the R / D ratio at the specified measurement position from the R / D ratio calculation unit 131 and causes the measurement value display unit 3510 to display it. According to such a display mode, it is possible to easily grasp the value of the R / D ratio at the measurement position closest to the position arbitrarily designated by the operator.

  When the operator designates a desired histogram in an R / D ratio graph 3520 described later by clicking the mouse 205 or the like, the control unit 10 performs the R corresponding to the designated histogram in the same manner as described above. The value of the / D ratio is displayed on the measurement value display unit 3510. It should be noted that this function may be omitted when the R / D ratio value is displayed beside each histogram as described later.

  Next, a display mode of graph information representing values of a plurality of R / D ratios R / D (i) will be described. The R / D ratio graph 3520 of the measurement result display screen 3500 is a graph in which the R / D ratios R / D (i) calculated in Step 8 are displayed in a histogram.

  A character string displayed beside each histogram will be described (only the uppermost histogram will be described). The character string “@ 000” indicates that this histogram represents the value of the R / D ratio at a position (left position) at an angle of 0 degrees. The character string “0.216” represents the R / D ratio value indicated by the histogram. In FIG. 13, 72 histograms are arranged and displayed at intervals of 5 degrees. In this way, the display control unit 102 operates to display a plurality of R / D ratio values R / D ratios (i) in association with the corresponding histograms.

  Here, the histogram of the predetermined range is displayed in a display mode different from the other histograms. In FIG. 13, histograms in the ranges of 60 to 120 degrees and 240 to 300 degrees are displayed in different display modes. As a display mode of this histogram, for example, the display color can be changed (that is, color-coded display), the display density can be changed, or the display pattern (design) can be changed. Generally, the display control unit 102 operates to classify a plurality of R / D ratio values R / D (i) into two or more ranges and display a plurality of histograms in a display mode for each classification.

  The display result of the measurement result will be further described with reference to FIG. The measurement result display screen 3600 shown in FIG. 14 is different from the case of FIG. 13 in which a plurality of designated positions are approximated by an ellipse, and is a closed curve such as a spline curve passing through a plurality of points input on a position corresponding to the outer edge of the optic disc. It is an example of a display screen in the case of using (see the description of step 5).

  On the fundus image GLR on the measurement result display screen 3600, an image representing the outer edge D of the optic nerve head region, an image representing the outer edge C of the recessed region, an image representing the width R (i) of the rim region, and a diameter D ( i), D (v), D (V), D (h), D (H), C (v), and an image (linear image) representing at least one of C (h) are displayed. Is done.

  The measurement result display screen 3600 displays scale images 3640v and 3640h representing the distance on the fundus image GLR. The scale image 3640v represents the distance in the vertical direction. The scale image 3640h represents the distance in the horizontal direction. The operator can change the display position of each of the scale images 3640v and 3640h by a drag operation of the mouse 205. Thereby, the length of a desired part on the fundus image GLR and the distance between two points can be measured.

  Further, on the fundus image GLR on the measurement result display screen 3600, image information representing the distribution of the plurality of R / D ratio values R / D (i) calculated in step S8 is displayed. This image information represents at least the positional distribution of the value of the R / D ratio, and also represents the magnitude of the value of the R / D ratio.

  This image information is displayed on the optic disc area (outer edge) R in particular. First, the position on the optic nerve head region D corresponding to the measurement site where the R / D ratio value R / D (i) is equal to or less than the predetermined threshold is displayed in a display mode different from the other positions. In this display mode, image information of a display color, display density, or display pattern different from other positions is displayed. Moreover, you may make it display the linear image of the thickness different from another position.

  In FIG. 14, R / D ratio = 0.1 is applied as a predetermined threshold, and image information d1 is displayed at a position on the optic disc region D corresponding to a range of angles 305 degrees to 325 degrees, and the angle Image information d2 is displayed at a position corresponding to a measurement position of 340 degrees.

  In FIG. 14, the image information d3 is displayed at a position on the optic disc region D corresponding to 11:00 to 1 o'clock, and the image information d4 is displayed at a position corresponding to 5 o'clock to 7 o'clock.

  Furthermore, the display aspect regarding a R / D ratio graph is demonstrated, referring FIG. The histogram included in the R / D ratio graph 3620 shown in FIG. 14 includes the R / D ratio value R / D (i) equal to or less than a predetermined threshold (= 0.1) and a predetermined range (11:00 to 1 o'clock). (A range corresponding to 5 o'clock to 7 o'clock) and those other than that. Here, the former is given priority for those that are equal to or smaller than the predetermined threshold and are included in the predetermined range.

  The display control unit 102 displays these three classifications in different display modes. For example, a histogram below a predetermined threshold is displayed in red, a histogram included in a predetermined range is displayed in yellow, and other histograms are displayed in green. Here, reference numerals 3620a and 3620b indicate histograms having a predetermined threshold value or less. Thus, by changing the display mode of the histogram, the operator can easily grasp the histogram (measurement position) to be noted.

  A mark display field in which a mark (for example, a black circle) indicating that the R / D ratio value R / D (i) is equal to or less than a predetermined threshold is displayed at a further horizontal position of the character string next to the R / D ratio graph 3620. 3650 is provided. The display control unit 102 extracts the R / D ratio value R / D (i) that is equal to or less than a predetermined threshold value, and displays the mark in the corresponding field in the mark display field 3650. Thereby, the operator can easily grasp a particularly noteworthy histogram (measurement position), that is, a measurement position having a small R / D ratio.

  In a further horizontal position of the mark display field 3650, another mark display field 3660 for displaying a mark (star) indicating the range of the preset measurement position is provided. The display of the mark in the mark display field 3660 is executed by the display control unit 102. In FIG. 14, marks are displayed at measurement positions in a range corresponding to 11:00 to 1 o'clock and measurement positions in a range corresponding to 5 o'clock to 7 o'clock. As a result, it is possible to easily grasp the measurement region of the attention range set in advance. The mark displayed in the mark display field 3660 corresponds to an example of “designated part information” representing a part of a fundus image designated in advance. It should be noted that the part for displaying the designated part information may be a default part or may be designated manually by the operator.

  In each range where the R / D ratio value R / D (i) is less than or equal to a predetermined threshold value, a mark 3670 indicating the measurement position having the smallest value within the range is displayed at the right end of the screen. In FIG. 14, marks 3670 are displayed at a measurement position with an angle of 315 degrees and a measurement position with an angle of 340 degrees.

  Further, a mark 3680 indicating the measurement position having the smallest value among all the calculated R / D ratio values R / D (i) is also displayed at the right end of the screen. In FIG. 14, the character string “Min” is displayed as the mark 3680.

  Next, display control in which the fundus image GLR and the R / D ratio graph 3620 are linked will be described. First, when the operator designates a position on the fundus image GLR by clicking the mouse 205 or the like, the position specifying unit 101 obtains the measurement position of the R / D ratio that is closest to the designated position. And the display control part 102 changes the display mode of the histogram corresponding to the calculated | required measurement position. For example, the display mode is changed by inverting the display color or changing it to a predetermined display color.

  On the other hand, when the operator designates a histogram in the R / D ratio graph 3620 by clicking the mouse 205 or the like, position information indicating the position on the fundus image GLR corresponding to the designated histogram is displayed. As this position information, image information such as a dot-like image indicating the position or an image on a line can be used. When a plurality of histograms are designated, for example, linear image information indicating the designated range can be displayed.

  Finally, the average value of the R / D ratio will be described. When the operator specifies a range on the fundus image GLR by dragging the mouse 205 or the like (R / D ratio measurement site range), the position specifying unit 101 specifies a measurement site included in the specified range. The average value calculator 132 calculates the average value of the R / D ratio values R / D (i) calculated by the R / D ratio calculator 131 for the specified measurement site. The display control unit 102 displays the calculated average value on the measurement result display screen 3600.

  When the operator designates a histogram in the R / D ratio graph 3620 by clicking the mouse 205 or the like, the average value computing unit 132 calculates the R calculated by the R / D ratio computing unit 131 for the designated measurement site. The average value of the values / D ratio R / D (i) is calculated. The display control unit 102 displays the calculated average value on the measurement result display screen 3600.

[Action / Effect]
The operation and effect of the fundus image processing apparatus 1 as described above will be described.

  The fundus image processing apparatus 1 analyzes the image data of the fundus image, and the ratio between the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region (ie R / D ratio) is calculated. At this time, the R / D ratio is acquired for each of a plurality of parts of the rim region. Furthermore, the fundus image processing apparatus 1 operates to display the fundus image and display image information representing the distribution of the plurality of acquired R / D ratio values on the fundus image.

  According to the fundus image processing apparatus 1 as described above, since the image information indicating the distribution of the plurality of R / D ratio values is displayed on the fundus image, the operator can set the R / D ratio value. Can be intuitively grasped. Therefore, it is possible to display an index (R / D ratio) obtained by analyzing the fundus image with high visibility.

  Further, the fundus image processing apparatus 1 is configured to classify a plurality of R / D ratio values into two or more ranges and display image information with each classification as a different display mode. Specifically, a plurality of R / D ratio values are classified into those having a predetermined threshold value or less and those included in a predetermined range set in advance, and each classification is displayed in a different display mode (for example, color-coded display). It is supposed to be displayed. Therefore, it is possible to display the R / D ratio obtained by analyzing the fundus image with high visibility. In particular, by displaying the image information at the outer edge position of the optic disc area, the R / D ratio can be displayed with good visibility.

  Further, when the position on the displayed fundus image is designated by the operator, the fundus image processing apparatus 1 can display the R / D ratio value corresponding to the designated position. The measurement result of the R / D ratio at the position can be easily grasped.

  The fundus image processing apparatus 1 can calculate and display the average value of the R / D ratio in the designated region when the region on the displayed fundus image is designated by the operator. The average value of the R / D ratio in a desired range can be easily grasped.

  The fundus image processing apparatus 1 analyzes the image data of the fundus image, and the ratio between the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region (ie R / D ratio) is acquired for a plurality of parts of the rim region, and graph information representing the values of the plurality of R / D ratios is displayed together with the fundus image.

  According to such a fundus image processing apparatus 1, it is possible to display graph information representing measurement results of a plurality of R / D ratios, so that an operator can intuitively understand a plurality of R / D ratio values and their distribution. Can be grasped. Therefore, it is possible to display an index (R / D ratio) obtained by analyzing the fundus image with high visibility.

  Further, the fundus image processing apparatus 1 displays graph information in which each value of a plurality of R / D ratios is represented by a histogram, so that the operator can display the distribution of the values of the plurality of R / D ratios. It can be grasped intuitively.

  Further, the fundus image processing apparatus 1 classifies a plurality of R / D ratio values into a range of 2 or more, and displays graph information with each classification as a different display mode. Specifically, a plurality of R / D ratio values are classified into those having a predetermined threshold value or less and those included in a predetermined range set in advance, and each classification is displayed in a different display mode (for example, color-coded display). It is supposed to be displayed. Therefore, it is possible to display a plurality of R / D ratios obtained by analyzing the fundus image with high visibility.

  Further, according to the fundus image processing apparatus 1, the designated part information indicating the part of the fundus image designated in advance can be displayed in association with the graph information, so that the operator can easily obtain information on the part designated in advance. Can be specified.

  In addition, the fundus image processing apparatus 1 can display a plurality of acquired R / D ratio values in association with graph information. Specifically, a character string indicating the measurement site and a value of the R / D ratio are displayed in the horizontal position of the graph information (R / D ratio graph). According to such a configuration, the operator can easily grasp the measurement result (measurement value) corresponding to the graph information.

  In addition, when the information (histogram) in the displayed graph information is designated by the operator, the fundus image processing apparatus 1 calculates and displays the average value of the R / D ratio corresponding to the designated information. Therefore, the operator can easily grasp the average value of the R / D ratio in a desired range.

  Further, according to the fundus image processing apparatus 1, when the position on the displayed fundus image is designated by the operator, the display mode of the information (histogram) in the graph information corresponding to the designated position is changed. Since it acts, the operator can easily grasp the information in the graph information corresponding to the desired position.

  Further, according to the fundus image processing apparatus 1, when information (histogram) in the displayed graph information is designated by the operator, position information indicating a position on the fundus image corresponding to the designated information is displayed. Therefore, the operator can easily grasp the position on the fundus image corresponding to the desired information in the graph information.

  Further, according to the fundus image processing apparatus 1, various types of information usable for diagnosis can be obtained and displayed. The displayed information includes the nipple outer edge image, the recessed outer edge image, the image representing the width of the rim area, the image representing the outer edge diameter of the optic nerve head area, the scale image, the area of the optic nerve head area, the area of the recessed area, There are an area of the rim region, an area ratio of the rim region and the optic disc region, an area ratio of the recessed region and the optic disc region, a C / D ratio, and the like.

[Modification]
A modification of the fundus image processing apparatus 1 according to this embodiment will be described.

  In the above embodiment, histograms of measurement results of a plurality of R / D ratios are displayed as graph information. However, in the fundus image processing apparatus according to the present invention, other types of graph information can be displayed. it can. For example, a graph in which measurement results of a plurality of R / D ratios are plotted, a line graph formed by connecting a plurality of R / D ratio measurement results, and the like can be displayed.

  In the above-described embodiment, the measurement results of a plurality of R / D ratios are classified into those that are equal to or less than a predetermined threshold value, those that correspond to parts that are designated in advance, etc., but any other classification is possible. It can be carried out.

  In addition, it is possible to configure so that the outer edge of the optic disc area and the outer edge of the recessed area that have been set can be appropriately corrected. For example, the position of the outer edge can be corrected by dragging with the mouse 205 a part of the outer edge that has already been set and displayed. When the position of the outer edge is corrected, the C / D ratio, the R / D ratio, the area, the area ratio, and the like can be calculated again based on the new outer edge position, and the calculation result can be displayed. . In addition, graph information and image information can be obtained and displayed again. Note that such correction is started by clicking the correction button among the operation buttons 3530 and 3630 shown in FIGS.

  In the above embodiment, the image information is displayed on the fundus image and the graph information is displayed. However, a configuration in which only one of them is displayed can be applied. . It is also possible to configure so that one or both of image information and graph information can be switched and displayed as appropriate.

  In the above-described embodiment, the operator manually designates the outer edge of the optic disc area and the outer edge of the recessed area, but it is configured so that it is automatically designated by any method similar to the conventional one. It is also possible to do.

<Second Embodiment>
A second embodiment of the fundus image processing apparatus according to the present invention will be described. The fundus image processing apparatus according to this embodiment is suitably used when two fundus images acquired at different dates and times are compared, for example, during follow-up observation.

  The fundus image processing apparatus according to this embodiment has the same configuration as that of the first embodiment. FIG. 15 shows an example of the configuration of the fundus image processing apparatus 1 ′ according to this embodiment. The fundus image processing apparatus 1 ′ is provided with a difference calculation unit 136. Although the position specifying unit 101 and the average value calculating unit 132 are not illustrated in FIG. 15, the fundus image processing apparatus 1 ′ may include the position specifying unit 101 and the average value calculating unit 132.

  The fundus image processing apparatus 1 ′ receives from the ophthalmologic image database 2000 image data G <b> 1 and G <b> 2 of two fundus images acquired at different dates and times for the same fundus. Here, it is assumed that the fundus image G1 is acquired before the fundus image G2.

  As described above, each fundus image is stored in association with incidental information such as the patient ID, the left and right eyes, and the shooting date and time. The fundus image processing apparatus 1 ′ refers to the accompanying information and recognizes that the image data is for the same fundus and also recognizes that the image data is acquired at different dates and times. Note that “different date and time” means that at least one of date and time is different.

  The R / D ratio calculation unit 131 analyzes each of the fundus images (image data thereof) G1 and G2, and calculates a plurality of R / D ratio values in the same manner as in the first embodiment. Here, for each fundus image G1, G2, the R / D ratio is acquired for the same measurement site. Hereinafter, for each measurement site i (for example, i = 1 to 72), the R / D ratio value in the fundus image G1 is represented by R / D1 (i), and the R / D ratio value in the fundus image G2 is represented by R / D2. It will be represented by (i).

  The difference calculation unit 136 calculates a difference between each of the plurality of R / D ratio values R / D1 (i) and R / D2 (i) acquired for each fundus image G1, G2: difference ΔR / D ( i) = ΔR / D2 (i) −ΔR / D1 (i). According to the definition of this difference, when the value of ΔR / D (i) is positive, it means that the value of the R / D ratio has increased, and when the value of ΔR / D (i) is 0 Means that the value of the R / D ratio has not changed, and if the value of ΔR / D (i) is negative, it means that the value of the R / D ratio has decreased.

  It is also possible to define the difference ΔR / D (i) ′ = ΔR / D1 (i) −ΔR / D2 (i). In this case, the meaning of the difference value is opposite to the above definition.

  The display control unit 102 displays the fundus image G2 on the display unit 141, and displays difference image information representing the distribution of a plurality of difference values ΔR / D (i) calculated by the difference calculation unit 136 on the fundus image G2. Display.

  The difference image information is displayed together with an image representing the outer edge D of the optic disc area or an image representing the outer edge C of the recessed area as shown in FIG. 14, for example, and the difference value ΔR / D (i) is Image information that represents a measurement site that is a negative value (referred to as first image information), or image information that represents a measurement site for which the difference value ΔR / D (i) is less than or equal to a predetermined negative value (second image information) Called image information).

  Here, the first image information represents a portion where the value of the R / D ratio has decreased between the acquisition date and time of the fundus image G1 and the acquisition date and time of the fundus image G2. The second image information represents a portion where the R / D ratio value has decreased by a predetermined value or more between the acquisition date and time of the fundus image G1 and the acquisition date and time of the fundus image G2. These pieces of image information are particularly useful for observation of glaucoma.

  According to such a fundus image processing apparatus 1 ′, the operator can intuitively grasp the distribution of changes in the value of the R / D ratio, and therefore an index (R / D) obtained by analyzing the fundus image. Ratio change) can be displayed with good visibility.

  The display control unit 102 can classify a plurality of difference values ΔR / D (i) into two or more ranges, and display the difference image information with each classification as a different display mode. For example, the first image information can be displayed in yellow, the second image information can be displayed in red, and the other measurement site (the outer edge D of the optic nerve head region) can be displayed in green. With this configuration, it is possible to display a change in the R / D ratio with high visibility.

  It is also possible to display the difference image information on the previous fundus image G1. Alternatively, both fundus images G1 and G2 may be displayed simultaneously, and difference image information may be displayed on one or both of them. Furthermore, it is also possible to configure these display modes to be switchable.

  The display control unit 102 selects a part corresponding to an R / D ratio equal to or less than a predetermined threshold (for example, 0.1) among a plurality of R / D ratio values R / D1 (i) acquired for the fundus image G1. Information to be displayed can be displayed on the later fundus image G2. According to this, the operator can easily grasp the part on the fundus image G2 after corresponding to the part where the value of the R / D ratio was small at the previous photographing date and time, which is convenient for follow-up observation and the like. is there.

  In addition, the display control unit 102 displays information representing a part corresponding to an R / D ratio that is equal to or less than a predetermined threshold among a plurality of R / D ratio values R / D2 (i) acquired for the subsequent fundus image G2. It can be displayed on the previous fundus image G1. According to this, the operator can easily grasp the part on the fundus image G1 corresponding to the part where the value of the R / D ratio becomes small at a later photographing date and time, which is convenient for follow-up observation and the like. is there.

  Furthermore, the display control unit 102 can display difference graph information representing a plurality of difference values ΔR / D (i) calculated by the difference calculation unit 136 together with the fundus image G1 and the fundus image G2.

  The difference graph information may be, for example, a histogram for each measurement region as shown in FIG. 13 or FIG. 14, or a graph or a line graph in which the difference value ΔR / D (i) of each measurement region is plotted. It may be.

  According to such a fundus image processing apparatus 1 ′, the operator can intuitively grasp a plurality of R / D ratio difference values and their distributions, and therefore an index obtained by analyzing the fundus image. (R / D ratio difference) can be displayed with good visibility.

  The display control unit 102 can also classify the plurality of difference values ΔR / D (i) into two or more ranges, and display the difference graph information with each classification as a different display mode. For example, the histogram corresponding to the first image information described above can be displayed in yellow, the histogram corresponding to the second image information can be displayed in red, and the histograms corresponding to other measurement parts can be displayed in green. . With this configuration, it is possible to display a change in the R / D ratio with high visibility.

  In the above embodiment, the difference image information is displayed on the fundus image and the difference graph information is displayed. However, a configuration in which only one of these is displayed can be applied. It is. In addition, one or both of the difference image information and the difference graph information can be appropriately switched and displayed.

  In addition, any configuration or operation described in the first embodiment can be appropriately applied to the second embodiment.

<About fundus photography device>
The fundus imaging apparatus according to the present invention is an apparatus capable of capturing a fundus image of a subject's eye and acquiring image data (digital data) as in the fundus imaging apparatus 1000 of the first embodiment. It is an apparatus including a computer having functions of the fundus image processing apparatus 1 according to the embodiment and the fundus image processing apparatus 1 ′ according to the second embodiment.

  The configuration for capturing the image data by capturing the fundus image functions as the “acquisition means” of the present invention, and is similar to, for example, a general fundus camera, an optical coherence tomography device, a scanning laser ophthalmoscope, It has a configuration.

<About the program>
The program according to the present invention is a computer program that includes display means for displaying a fundus image and causes a computer that processes image data of the fundus image to function as the above-described fundus image processing apparatus 1 or fundus image processing apparatus 1 ′. (See the description of the above embodiment for the function).

  The program according to the present invention can be recorded on any recording medium that can be read by a drive device of a computer. For example, a recording medium such as an optical disk, a magneto-optical disk (CD-ROM / DVD-RAM / DVD-ROM / MO, etc.), a magnetic storage medium (hard disk / floppy (registered trademark) disk / ZIP, etc.) can be used. is there. It can also be stored in a storage device such as a hard disk drive or memory. Further, this program can be transmitted through a network such as the Internet or a LAN.

It is a schematic block diagram showing an example of composition of a 1st embodiment of a fundus image processing device concerning this invention. It is a schematic block diagram showing an example of composition of a 1st embodiment of a fundus image processing device concerning this invention. It is a schematic explanatory drawing for demonstrating an example of the measurement aspect of R / D ratio by 1st Embodiment of the fundus image processing apparatus concerning this invention. It is a schematic explanatory drawing for demonstrating an example of the measurement aspect of C / D ratio by 1st Embodiment of the fundus image processing apparatus concerning this invention. It is a schematic explanatory drawing for demonstrating an example of the measurement aspect of C / D ratio by 1st Embodiment of the fundus image processing apparatus concerning this invention. It is a flowchart showing an example of the usage pattern of 1st Embodiment of the fundus image processing apparatus according to the present invention. It is the schematic showing an example of the display screen displayed by 1st Embodiment of the fundus-image processing apparatus concerning this invention. It is the schematic showing an example of the display screen displayed by 1st Embodiment of the fundus-image processing apparatus concerning this invention. It is the schematic showing an example of the display screen displayed by 1st Embodiment of the fundus-image processing apparatus concerning this invention. It is the schematic showing an example of the display screen displayed by 1st Embodiment of the fundus-image processing apparatus concerning this invention. It is the schematic showing an example of the display screen displayed by 1st Embodiment of the fundus-image processing apparatus concerning this invention. It is the schematic showing an example of the display screen displayed by 1st Embodiment of the fundus-image processing apparatus concerning this invention. It is the schematic showing an example of the display screen displayed by 1st Embodiment of the fundus-image processing apparatus concerning this invention. It is the schematic showing an example of the display screen displayed by 1st Embodiment of the fundus-image processing apparatus concerning this invention. It is a schematic block diagram showing an example of composition of a 2nd embodiment of a fundus oculi image processing device concerning this invention.

Explanation of symbols

1, 1 ′ fundus image processing apparatus 10 control unit 101 position specifying unit 102 display control unit 11 image receiving unit 12 image storage unit 13 image analyzing unit 131 R / D ratio calculating unit 132 average value calculating unit 133 C / D ratio calculating unit 134 Area Calculation Unit 135 Area Ratio Calculation Unit 136 Difference Calculation Unit 14 User Interface 141 Display Unit 142 Operation Unit 200 Microprocessor 201 RAM
202 Nonvolatile storage device 203 Display 204 Keyboard 205 Mouse 206 Communication interface 1000 Fundus photographing device 2000 Ophthalmic image database P Program

Claims (44)

Analyzing the image data of the fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region Analyzing means for calculating a plurality of R / D ratios by respectively calculating
Display means;
Control means for displaying the fundus image on the fundus image while displaying the fundus image on the display means, and displaying image information representing a distribution of R / D ratio values acquired by the analysis means;
A fundus image processing apparatus comprising: The control means classifies the plurality of R / D ratio values into a range of 2 or more, and displays the image information with each classification as a different display mode.
The fundus image processing apparatus according to claim 1. The control means displays the classifications in different colors as the different display modes.
The fundus image processing apparatus according to claim 2. The control means displays the image information at an outer edge position of the optic disc area in the fundus image.
The fundus image processing apparatus according to claim 1. Further comprising an operating means,
The control means causes the display means to display a value of an R / D ratio corresponding to the designated position when the position on the displayed fundus image is designated by the operation means.
The fundus image processing apparatus according to claim 1. Further comprising an operating means,
The analysis unit calculates an average value of the R / D ratio in the designated region when the region on the displayed fundus image is designated by the operation unit;
The control means displays the average value of the calculated R / D ratio on the display means.
The fundus image processing apparatus according to claim 1. Analyzing the image data of two fundus images acquired at different dates and times for the same fundus, and for each fundus image, the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region, The ratio of the outer rim diameter of the optic nerve head region is calculated for each of a plurality of parts of the rim region to obtain a plurality of R / D ratios, and the plurality of R / D ratios obtained for the respective fundus images An analysis means for calculating each difference;
Display means;
Control means for displaying at least one of the two fundus images on the display means, and displaying difference image information representing the distribution of the plurality of difference values calculated by the analysis means on the at least one fundus image. When,
A fundus image processing apparatus comprising: The control means classifies the plurality of difference values into two or more ranges, and displays the difference image information with each classification as a different display mode.
The fundus image processing apparatus according to claim 7. The control means displays information representing a part corresponding to an R / D ratio that is equal to or lower than a predetermined threshold among the plurality of acquired R / D ratios for one fundus image of the two fundus images. Display on top,
The fundus image processing apparatus according to claim 7. Analyzing the image data of the fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region Analyzing means for calculating a plurality of R / D ratios by respectively calculating
Display means;
Control means for displaying graph information representing a plurality of R / D ratio values acquired by the analyzing means on the display means together with the fundus image;
A fundus image processing apparatus comprising: The control means displays the graph information representing each value of the plurality of R / D ratios by a histogram;
The fundus image processing apparatus according to claim 10. The control means classifies the plurality of R / D ratio values into a range of 2 or more, and displays the graph information with each classification as a different display mode.
The fundus image processing apparatus according to claim 10. The control means displays the classifications in different colors as the different display modes.
The fundus image processing apparatus according to claim 12. The control means causes the display means to display designated part information indicating a part of a fundus image designated in advance in association with the graph information.
The fundus image processing apparatus according to claim 10. The control means causes the display means to display the plurality of R / D ratio values in association with the graph information.
The fundus image processing apparatus according to claim 10. Further comprising an operating means,
The analysis means calculates an average value of the R / D ratio corresponding to the designated information when the information in the displayed graph information is designated by the operation means,
The control means displays the average value of the calculated R / D ratio on the display means.
The fundus image processing apparatus according to claim 10. Analyzing the image data of two fundus images acquired at different dates and times for the same fundus, and for each fundus image, the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region, The ratio of the outer rim diameter of the optic nerve head region is calculated for each of a plurality of parts of the rim region to obtain a plurality of R / D ratios, and the plurality of R / D ratios obtained for the respective fundus images An analysis means for calculating each difference;
Display means;
Control means for causing the display means to display difference graph information representing the values of the plurality of differences calculated by the analyzing means together with at least one of the two fundus images;
A fundus image processing apparatus comprising: The control means classifies the plurality of difference values into two or more ranges, and displays the difference graph information with each classification as a different display mode.
The fundus image processing apparatus according to claim 17. The control means displays information representing a part corresponding to an R / D ratio that is equal to or lower than a predetermined threshold among the plurality of acquired R / D ratios for one fundus image of the two fundus images. Display on top,
The fundus image processing apparatus according to claim 17. Analyzing the image data of the fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region Analyzing means for calculating a plurality of R / D ratios by respectively calculating
Display means;
Graph information representing a plurality of R / D ratio values acquired by the analyzing means is displayed on the display means together with the fundus image, and image information representing the distribution of the R / D ratio values is displayed on the fundus image. Control means to be displayed on,
A fundus image processing apparatus comprising: Further comprising an operating means,
The control means changes a display mode of information in the graph information corresponding to the designated position when the position on the displayed fundus image is designated by the operation means.
The fundus image processing apparatus according to claim 20. Further comprising an operating means,
The control means causes the display means to display position information indicating a position on the fundus image corresponding to the designated information when information in the displayed graph information is designated by the operation means. ,
The fundus image processing apparatus according to claim 20. The control means displays a nipple outer edge image representing an outer edge position of the optic nerve head region and a depressed outer edge image representing an outer edge of the depressed region on the fundus image.
The fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17, or claim 20. The analysis means analyzes the image data of the fundus image to determine the center position of the optic nerve head region, and acquires R / D ratios at a plurality of sites at a constant angular interval centered on the center position.
The fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17, or claim 20. The control means displays an image representing the width of the rim region used for the calculation of the R / D ratio and an image representing the diameter of the outer edge of the optic nerve head region on the fundus image.
The fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17, or claim 20. The control means displays a scale image representing a distance on the displayed fundus image together with the fundus image.
The fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17, or claim 20. The analysis means analyzes the image data of the fundus image, calculates the area of the optic disc area and the area of the rim area,
The control means causes the display means to display the calculated area value of the optic disc area and the area value of the rim area.
The fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17, or claim 20. The analysis means calculates a ratio between the calculated area of the rim region and the area of the optic disc region,
The control means causes the display means to display a value of the calculated area ratio;
The fundus image processing apparatus according to claim 27. The analysis means analyzes the image data of the fundus image, calculates a ratio between the outer edge diameter of the recessed area and the outer edge diameter of the optic nerve head area, and obtains a C / D ratio;
The control means causes the display means to display the acquired value of the C / D ratio.
The fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17, or claim 20. The analysis means calculates, as the C / D ratio, a ratio between the maximum diameter of the outer edge of the recessed area and the maximum diameter of the outer edge of the optic disc area,
30. The fundus image processing apparatus according to claim 29. The analysis means calculates, as the C / D ratio, a ratio between the maximum diameter of the outer edge of the recessed area and the diameter of the outer edge of the optic disc area passing through the maximum diameter.
30. The fundus image processing apparatus according to claim 29. The analysis means analyzes the image data of the fundus image, calculates the area of the optic disc area and the area of the recessed area,
The control means causes the display means to display the calculated area value of the optic disc area and the area value of the recessed area.
The fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17, or claim 20. The analysis means calculates a ratio between the calculated area of the recessed region and the area of the optic nerve head region,
The control means causes the display means to display a value of the calculated area ratio;
The fundus image processing apparatus according to claim 32, wherein: Further comprising an operating means,
The analysis means, based on the outer edge of the optic papilla region and the outer edge of the recessed area specified on the displayed fundus image by the operation means, the width of the rim area and the diameter of the outer edge of the optic nerve head area And
The fundus image processing apparatus according to claim 1, claim 7, claim 10, claim 17, or claim 20. Obtaining means for photographing the fundus and obtaining image data of the fundus image;
Analyzing the image data of the acquired fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region An analysis means for calculating a plurality of R / D ratios by calculating each of a plurality of parts of the region;
Display means;
Control means for displaying the fundus image on the fundus image while displaying the fundus image on the display means, and displaying image information representing a distribution of R / D ratio values acquired by the analysis means;
A fundus photographing apparatus comprising: Obtaining means for photographing the fundus and obtaining image data of the fundus image;
Image data of two fundus images acquired at different dates and times for the same fundus by the acquiring unit is analyzed, and for each fundus image, a rim region sandwiched between the outer edge of the optic disc region and the outer edge of the recessed region The ratio between the width and the diameter of the outer edge of the optic papilla region is calculated for each of a plurality of portions of the rim region to obtain a plurality of R / D ratios, and the plurality of R acquired for each fundus image An analysis means for calculating each difference of the / D ratio;
Display means;
Control means for displaying at least one of the two fundus images on the display means, and displaying difference image information representing the distribution of the plurality of difference values calculated by the analysis means on the at least one fundus image. When,
A fundus photographing apparatus comprising: Obtaining means for photographing the fundus and obtaining image data of the fundus image;
Analyzing the image data of the acquired fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region An analysis means for calculating a plurality of R / D ratios by calculating each of a plurality of parts of the region;
Display means;
Control means for displaying graph information representing a plurality of R / D ratio values acquired by the analyzing means on the display means together with the fundus image;
A fundus photographing apparatus comprising: Obtaining means for photographing the fundus and obtaining image data of the fundus image;
Image data of two fundus images acquired at different dates and times for the same fundus by the acquiring unit is analyzed, and for each fundus image, a rim region sandwiched between the outer edge of the optic disc region and the outer edge of the recessed region The ratio between the width and the diameter of the outer edge of the optic papilla region is calculated for each of a plurality of portions of the rim region to obtain a plurality of R / D ratios, and the plurality of R acquired for each fundus image An analysis means for calculating each difference of the / D ratio;
Display means;
Control means for causing the display means to display difference graph information representing the values of the plurality of differences calculated by the analyzing means together with at least one of the two fundus images;
A fundus photographing apparatus comprising: Obtaining means for photographing the fundus and obtaining image data of the fundus image;
Analyzing the image data of the acquired fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region An analysis means for calculating a plurality of R / D ratios by calculating each of a plurality of parts of the region;
Display means;
Graph information representing a plurality of R / D ratio values acquired by the analyzing means is displayed on the display means together with the fundus image, and image information representing the distribution of the R / D ratio values is displayed on the fundus image. Control means to be displayed on,
A fundus photographing apparatus comprising: A computer comprising display means for displaying a fundus image and processing image data of the fundus image;
Analyzing the image data of the fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region Each functioning as an analysis means for obtaining a plurality of R / D ratios,
Displaying the fundus image on the display unit, and functioning as a control unit for displaying image information representing a distribution of R / D ratio values acquired by the analysis unit on the fundus image;
A program characterized by that. A computer comprising display means for displaying a fundus image and processing image data of the fundus image;
Analyzing the image data of two fundus images acquired at different dates and times for the same fundus, and for each fundus image, the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region, The ratio of the outer rim diameter of the optic nerve head region is calculated for each of a plurality of parts of the rim region to obtain a plurality of R / D ratios, and the plurality of R / D ratios obtained for the respective fundus images Function as an analysis means to calculate each difference,
Control means for displaying at least one of the two fundus images on the display means, and displaying difference image information representing the distribution of the plurality of difference values calculated by the analysis means on the at least one fundus image. Make it work,
A program characterized by that. A computer comprising display means for displaying a fundus image and processing image data of the fundus image;
Analyzing the image data of the fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region Each functioning as an analysis means for obtaining a plurality of R / D ratios,
Causing the display means to display graph information representing a plurality of R / D ratio values acquired by the analysis means together with the fundus image;
A program characterized by that. A computer comprising display means for displaying a fundus image and processing image data of the fundus image;
Analyzing the image data of two fundus images acquired at different dates and times for the same fundus, and for each fundus image, the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region, The ratio of the outer rim diameter of the optic nerve head region is calculated for each of a plurality of parts of the rim region to obtain a plurality of R / D ratios, and the plurality of R / D ratios obtained for the respective fundus images Function as an analysis means to calculate each difference,
Causing difference graph information representing the values of the plurality of differences calculated by the analysis means to function as a control means for displaying on the display means together with at least one of the two fundus images;
A program characterized by that. A computer comprising display means for displaying a fundus image and processing image data of the fundus image;
Analyzing the image data of the fundus image, the ratio of the width of the rim region sandwiched between the outer edge of the optic nerve head region and the outer edge of the recessed region and the diameter of the outer edge of the optic nerve head region Each functioning as an analysis means for obtaining a plurality of R / D ratios,
Graph information representing a plurality of R / D ratio values acquired by the analyzing means is displayed on the display means together with the fundus image, and image information representing the distribution of the R / D ratio values is displayed on the fundus image. Function as a control means to display
A program characterized by that.

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