JP4932760B2 - Decontamination method and decontamination system - Google Patents

Description

  The present invention provides a decontamination method for supplying a decontamination gas to a decontamination chamber, condensing the decontamination gas on the surface of the decontamination target in the decontamination chamber, and decontaminating the decontamination target, and The present invention relates to a decontamination system for decontaminating the decontamination object.

  Conventionally, decontamination chambers such as isolators, chambers, and clean rooms (sterile chambers) constituting decontaminated spaces are well known in pharmaceutical manufacturing plants and the like. Then, a decontamination gas such as hydrogen peroxide gas is supplied to the decontamination chamber, and the decontamination gas is condensed on the surface of the decontamination target placed in the decontamination chamber. It has also been proposed to decontaminate (see Patent Document 1). Here, decontamination includes chemical T-phase decontamination, sterilization, sterilization, sterilization, and the like.

  By the way, in order to reliably decontaminate the decontamination object, the surface of the decontamination object is always in contact with the decontamination gas, and a condensation film of the decontamination gas is formed on the surface. There is a need. On the other hand, even if the condensed film is formed on the surface of the object to be decontaminated, it is known that the condensed film evaporates from the surface of the object to be decontaminated and decomposes at the same time. For this reason, even if a condensation film is formed on the surface of the object to be decontaminated, it has been confirmed that the decontamination effect declines after a predetermined time. For this reason, conventionally, the decontamination chamber is made to flow the room air containing the decontamination gas at a constant wind speed so as to supply the decontamination gas component lost from the surface of the decontamination object. It was preventing the decline.

JP 2007-54447 A

  However, in the conventional decontamination method for maintaining the decontamination effect by flowing the room air at a constant wind speed, the external shape of the decontamination target contained in the decontamination chamber is a complicated shape. In addition, there is a case where a desired decontamination cannot be performed due to insufficient formation of a condensed film of the decontamination gas in the details of the outer shape.

  Then, this invention aims at providing the decontamination method and decontamination system which can solve the said subject.

In view of the above problems, the present inventors have invented the following configuration. The present invention supplies a decontamination gas to the decontamination chamber, and causes a room air containing the decontamination gas to flow in the decontamination chamber by a blower provided in the decontamination chamber. In the decontamination method of decontaminating the decontamination object by condensing the decontamination gas and condensing the decontamination gas on the surface of the decontamination object in the decontamination chamber, controlling the blower Accordingly, the wind speed of the indoor air flowing in the decontamination chamber, decontamination to an object in the condensed film is formed, after maintaining at a predetermined first wind speed, the second wind speed slower than the first wind speed The indoor air decelerating step for maintaining or growing the condensed film is performed by maintaining the air flow rate for a predetermined time or by stopping the air blower and setting the wind speed of the indoor air to 0 for a predetermined time. It is a dyeing method.

To restate, the main part of the present invention is to execute the indoor air deceleration step, and the indoor air deceleration step is performed after maintaining the wind speed of the indoor air at the first wind speed for a predetermined time, The wind speed is maintained for a predetermined time, or the wind speed of the room air is set to 0 for a predetermined time.
In such a configuration, the present inventor condenses the decontamination gas on the detailed surface of the decontamination object when the wind speed of the indoor air is changed from the first wind speed to the second wind speed or from the first wind speed to zero wind speed. Found to be promoted. Here, the present inventor considered the reason why the condensation of the decontamination gas is promoted as follows. Conventionally, indoor air containing decontamination gas is caused to flow at a constant wind speed for the reasons described above. In such a measure, while the decontamination gas is supplied to the surface of the object to be decontaminated, It was thought that the decontamination gas was removed from the surface of the decontamination object, preventing the formation of a condensed film. That is, when the influence of removal of the decontamination gas is large with respect to the supply of the decontamination gas to the object to be decontaminated, the condensation film is not sufficiently formed, the decontamination effect is reduced, and the decontamination is not performed. I thought it would be stable. Therefore, in the present invention, when the room air containing the decontamination gas is changed from the first wind speed to the second wind speed, or from the first wind speed to the wind speed 0, the decontamination gas quickly enters the room due to the first wind speed. The condensing film is easily maintained or grown by the second wind speed or zero wind speed, and the condensing film is stably formed on the detailed surface.

The indoor air deceleration process is repeated a plurality of times .

  Such a configuration further stabilizes the formation of the condensed film in the details of the complicated shape of the object to be decontaminated.

In the decontamination method, in the indoor air deceleration step, the decontamination gas is supplied into the decontamination chamber by a first supply amount during a time period maintained at the first wind speed, and is slower than the first wind speed. The decontamination gas is supplied in a second supply amount that is less than the first supply amount during the time that the second wind speed is maintained or the time that the wind speed of the room air is zero .

  By adopting such a configuration, it is possible to reduce the decontamination gas consumption as a whole as compared with the conventional one while maintaining the decontamination effect, and it is possible to suppress the cost for decontamination.

In addition, a decontamination chamber to which decontamination gas is supplied, a blower provided in the decontamination chamber for flowing room air containing the decontamination gas in the decontamination chamber, and controlling the blower to perform the decontamination. Blower control means for changing the wind speed of the indoor air flowing in the dyeing chamber, a condensation sensor for detecting that the decontamination gas has condensed on the surface of the object to be decontaminated, and supplying the decontamination gas to the decontamination chamber A decontamination gas supply device, and the air blower control means controls the air blower to flow the indoor air containing the decontamination gas supplied by the decontamination gas supply device in the decontamination chamber. The decontamination system distributes the decontamination gas into the decontamination chamber and condenses the decontamination gas on the surface of the decontamination target in the decontamination chamber to decontaminate the decontamination target, blower control means controls the blower, the condensing Nsa until detecting that the decontamination gas at the surface of the decontamination object is condensed, after the wind velocity of the indoor air flowing in the decontamination chamber is maintained at a predetermined first wind speed, the first wind speed Maintaining indoor air deceleration control contents to maintain or grow the condensed film by maintaining the slower second wind speed for a predetermined time or by stopping the blower and setting the wind speed of the indoor air to 0 for a predetermined time. A decontamination system can be proposed.

Such decontamination system, stably formed coagulation Chijimimaku, or maintain or grown can Rukoto.

Further, in the decontamination system, the blower control means includes a control content that repeats the indoor air deceleration control content a plurality of times .

  By setting it as this structure, formation of a condensation film | membrane is further stabilized in the detail of the complicated shape of a decontamination target object.

Further, in the configuration that includes a decontamination gas supply apparatus control means for changing the supply amount of the decontamination gas by controlling the decontamination gas supply apparatus, said blower control means the wind speed of the indoor air The decontamination gas supply device control means controls the decontamination gas supply device to supply the decontamination gas into the decontamination chamber by the first supply amount during the time maintained at the first wind speed, and controls the blower device. The decontamination gas supply device control means controls the decontamination gas supply device when the means maintains the wind speed of the room air at a second wind speed slower than the first wind speed or when the air speed of the room air is zero. Then, the decontamination gas is supplied in a second supply amount smaller than the first supply amount .

  By adopting such a configuration, it is possible to reduce the decontamination gas consumption as a whole as compared with the conventional case, and it is possible to suppress the cost for decontamination.

In the present invention, since the room air containing the decontamination gas enters and stays in the details of the decontamination object, the formation , maintenance or growth of the condensed film is promoted even in the details, and the decontamination effect is obtained. Will definitely improve.

Examples of the decontamination method and decontamination system according to the present invention will be described with reference to FIGS.
As shown in FIG. 1, the decontamination system 1 includes an isolator 2 as a decontamination chamber. Here, the internal space of the isolator 2 is airtightly blocked from the outdoor. Then, a hydrogen peroxide gas, which is a decontamination gas, is supplied into the isolator 2, and further a decontamination object such as a syringe (syringe) before being injected with a chemical solution, which is placed in the work space 20 in the isolator 2. The hydrogen peroxide gas is condensed on the surface of X, and the condensed state is maintained for a predetermined time to decontaminate the surface and the like.

A specific configuration of the isolator 2 will be described.
As shown in FIG. 1, a vertical partition plate 3 for partitioning a room is provided in the isolator 2. And the clearance gap formed between this partition plate 3 and the inner wall of the isolator 2 becomes the surrounding circuit 20A through which room air can pass. In addition, an opening 3A is provided at the lower end of the partition plate 3 to communicate the work space 20 disposed in the center of the isolator 2 with the peripheral circuit 20A.

  In addition, a HEPA filter 4 for cleaning the indoor air of the isolator 2 is disposed horizontally in the upper portion of the isolator 2. Further, a rectifying plate 5 that regulates the airflow of room air is disposed directly below the HEPA filter 4.

  Further, in the isolator 2 and above the HEPA filter 4, three air blowers 15 that blow indoor air of the isolator 2 in one direction are installed side by side. In the present embodiment, the air blowing port 15a of each air blower 15 is installed so as to be directed downward and blow indoor air downward.

  With this configuration, the room air blown by the blower 15 passes through the HEPA filter 4, further passes through the current plate 5, and reaches the work space 20. Further, the room air enters the peripheral circuit 20A from the opening 3A of the partition plate 3, and ascends the peripheral circuit 20A. The room air reaches the installation space of the blower 15, is again blown downward by the blower 15, and circulates in the isolator 2. That is, the air blower 15 causes the indoor air in the isolator 2 to flow to form a one-way flow in the circulation system.

  Further, the decontamination system 1 includes a hydrogen peroxide gas generation and supply device 6. The hydrogen peroxide gas generation and supply device 6 includes a hydrogen peroxide solution tank 7 containing hydrogen peroxide solution, an evaporator 9 for evaporating the hydrogen peroxide solution, and a hydrogen peroxide solution in the hydrogen peroxide solution tank 7. And a hydrogen peroxide water supply pump 8 for supplying the water to the evaporator 9. Further, a hydrogen peroxide gas supply pipe 10 for guiding the hydrogen peroxide gas generated in the evaporator 9 to the vicinity of the air blowing port 15a of the air blowing device 15 is provided. The hydrogen peroxide gas generation and supply device 6 is preferably a known product. By the way, the hydrogen peroxide gas generation and supply device 6 constitutes the decontamination gas supply device of the present invention.

  In addition, an air supply circuit 21 including an air supply circuit HEPA filter 22 and an air supply device 23 is connected to the isolator 2. More specifically, the air supply circuit 21 is arranged with an air supply device 23 and an air supply circuit HEPA filter 22 in order from the outdoor side, with one end opened to the outside and the other end in the isolator 2. Communicate. When the air supply device 23 is driven, the outside air is supplied into the isolator 2 through the HEPA filter 22 for the air supply circuit.

  In addition, an exhaust circuit 24 including a catalyst 25, an adjustment valve 26, an exhaust circuit HEPA filter 27, and an exhaust device 28 is connected to the isolator 2. More specifically, the exhaust circuit 24 is arranged in order from the isolator 2 side with the catalyst 25, the adjustment valve 26, the exhaust circuit HEPA filter 27, and the exhaust device 28, and one end communicates with the isolator 2. The other end is open to the outdoors. When the exhaust device 28 is driven, the indoor air in the isolator 2 is decomposed by the catalyst 25, further cleaned by the exhaust circuit HEPA filter 27, and discharged outside the room. The adjustment valve 26 is used to adjust the exhaust amount of gas.

  The isolator 2 includes a condensation sensor 13. The condensation sensor 13 is configured such that the sensor unit 13a is disposed in the work space 20, and the hydrogen peroxide gas supplied to the work space 20 is condensed in the work space 20 or on the surface of the decontamination target X. Detect. As this condensation sensor 13, a well-known product is used suitably, For example, the structure described in PCT / JP / 03/05646 gazette is used. The condensation sensor 13 may be installed at an arbitrary position in the work space 20, but is preferably arranged at a so-called cold spot in the work space 20.

  The isolator 2 also measures a temperature sensor 12 that measures the room temperature of the work space 20, a humidity sensor 17 that measures humidity, a gas concentration meter 18 that measures the hydrogen peroxide gas concentration, and a wind speed of room air in the work space 20. An anemometer 19 is provided. As the temperature sensor 12, the humidity sensor 17, the gas concentration meter 18, and the anemometer 19, known products are preferably used.

  Further, as shown in FIG. 2, the decontamination system 1 includes a control device 30. The control device 30 includes a central control device CPU 40, a storage device ROM 41 and a storage device RAM 42 connected to the central control device CPU 40, respectively. Here, the central control unit CPU 40 executes a predetermined program. The storage device ROM 41 stores an operation program and data used for arithmetic processing. The storage device RAM 42 can read and write data at any time.

  Further, the control device 30 includes a hydrogen peroxide gas generation and supply device 6, a blower 15, a temperature sensor 12, a condensation sensor 13, a humidity sensor 17, a gas concentration meter 18, an anemometer 19, an air supply device 23, and an exhaust. Each device 28 is connected. Here, a blowing control command signal is output from the control device 30 to the blowing device 15, the air supply device 23, and the exhaust device 28. In response to the command signal, the fans inside the devices 15, 23, and 28 are driven at various rotational speeds (for example, times per minute [rpm]). Measurement data is transmitted from the temperature sensor 12, the condensation sensor 13, the humidity sensor 17, the gas concentration meter 18, and the anemometer 19 to the control device 30 as needed, and the measurement value is displayed on a measurement value display unit (not shown). Is done. In addition, the said control apparatus 30 provided with the program which controls the air blower 15 comprises the air blower control means which concerns on this invention. Further, the control device 30 having a program for controlling the hydrogen peroxide gas generation and supply device 6 constitutes a decontamination gas supply device control means according to the present invention.

Next, an outline of the decontamination method having the above configuration will be described.
First, the control device 30 controls the air supply device 23 to introduce an appropriate amount of air into the isolator 2 and outputs a control command signal to the blower device 15 to cause the indoor air in the isolator 2 to flow to cause the isolator 2 to flow. A unidirectional flow is formed in 2. Further, a gas supply control command signal is output to the hydrogen peroxide gas generation and supply device 6 to generate hydrogen peroxide gas, and a predetermined amount of hydrogen peroxide gas is introduced into the isolator 2 through the hydrogen peroxide gas supply pipe 18. Is supplied for a predetermined time. Then, the indoor air containing hydrogen peroxide gas circulates in the isolator 2, and the hydrogen peroxide gas reaches the isolator 2. Further, the control device 30 receives the measurement data of the temperature sensor 12, the condensation sensor 13, the humidity sensor 17, and the gas concentration meter 18, and displays the measurement values as needed. When the supply state of the hydrogen peroxide gas is maintained for a predetermined time in this way, the hydrogen peroxide gas is saturated in the isolator 2, and the hydrogen peroxide gas begins to condense on the surface of the decontamination target X, and the removal is performed. A condensed film is formed on the surface of the dyed object X. Further, this condensed film formation state is maintained for a predetermined time (condensed film formation maintaining step).

  When the condensation film maintenance time, which is a predetermined time for maintaining the formation of the condensation film, has elapsed, the control device 30 stops the supply of the hydrogen peroxide gas and controls the exhaust device 28 to perform the oxidation. Indoor air containing hydrogen gas is cleaned and exhausted out of the isolator 2 (aeration process). And decontamination of the decontamination target object X is completed.

Next, the main part of the present invention will be described. Specifically, the condensed film formation maintaining step will be described in detail.
In the condensed film formation maintaining step, the air blower 15 is controlled by the control device 30 to maintain the wind speed of the indoor air flowing in the isolator 2 at a predetermined first wind speed α for a predetermined time. Then, the room air is changed to a second wind speed β that is slower than the first wind speed α, and is maintained at the second wind speed β for a predetermined time. More specifically, as shown in FIG. 3, the indoor wind speed is set to the first wind speed α for a predetermined first wind speed maintaining time Tx1 until a condensation film is formed on the decontamination target X. Then, when the condensed film is formed and the first wind speed maintenance time Tx1 ends, the blower 15 is controlled to change the indoor wind speed to the second wind speed β, and the state of the second wind speed β is changed to a predetermined second wind speed. Only the maintenance time Tx2 is maintained.

  As described above, the decontamination system 1 of the present invention executes the contents of the indoor air deceleration control in which the control device 30 maintains the room air at the first wind speed α for a predetermined time and then maintains the room air at the second wind speed β for a predetermined time. It is a thing. The decontamination system 1 can execute an indoor air deceleration process in which the second wind speed β is maintained for a predetermined time after the first wind speed α is maintained for a predetermined time.

  With this configuration, the hydrogen peroxide gas easily enters and stays on the surface of the complicated shape of the decontamination target X. For this reason, the supply of hydrogen peroxide gas is sufficient, and the condensed film is stably formed in the details, and further, the condensed film is stably maintained or grown. Here, the first wind speed maintenance time Tx1 is a time for the purpose of forming a condensed film by spreading the hydrogen peroxide gas in the isolator 2 in a short time, and the second wind speed maintenance time Tx2 is formed. This is a time for the purpose of maintaining or growing the condensed film formed on the detailed surface of the decontamination object X or the like.

The first wind speed maintenance time Tx1 when the wind speed of the indoor air is the first wind speed α is controlled by the hydrogen peroxide gas generation and supply device 6 so that the hydrogen peroxide gas is supplied into the isolator 2 by a predetermined first supply amount. In the second wind speed maintenance time Tx2, a second supply amount of hydrogen peroxide gas smaller than the first supply amount is supplied into the isolator 2 .

  By adopting such a configuration, the supply amount of hydrogen peroxide gas can be reduced, so that the consumption of hydrogen peroxide gas can be suppressed without reducing the decontamination effect as a whole, and the cost for decontamination can be reduced. Is possible.

  The first wind speed α is appropriately changed depending on the measurement environment (the width of the work space 20, the appearance shape of the decontamination target X, room temperature, humidity, hydrogen peroxide gas concentration, etc.), but is 0.2 (m / It is desirable to set in the range of s) to 0.3 (m / s). Furthermore, it is desirable that the second wind speed β is decelerated to at least less than 0.2 (m / s). The second wind speed maintenance time Tx2 is preferably 12 minutes or longer if the so-called D value is 6D for bacteria having a so-called D value of 2 minutes. In addition, as for setting of this 2nd wind speed maintenance time Tx2, it is desirable to confirm about the decontamination effect beforehand using BI (biological indicator). The end timing of the first wind speed maintenance time Tx1 is preferably set to the timing at which the condensation film starts to be formed on the surface of the decontamination object X. The time until the formation is started may be calculated, and the end timing of the first wind speed maintenance time Tx1 may be programmed in the control device 30 in advance, or the condensation sensor 13 and the blower device 15 are linked, When the condensation sensor 13 detects condensation, the blower 15 may change the wind speed from the first wind speed α to the second wind speed β. In addition, even if it is the structure which programmed the completion | finish timing of 1st wind speed maintenance time Tx1 beforehand, in order to confirm condensation by the said condensation sensor 13, it is preferable to use auxiliary.

Moreover, the following structure is proposed as a modification.
In the condensed film maintaining step according to the present invention, after maintaining the wind speed of the indoor air flowing in the isolator 2 at a predetermined first wind speed α for a predetermined time, the wind speed is set to 0 and this state is maintained for a predetermined time. More specifically, as shown in FIG. 4, the air blower 15 is stopped after a predetermined first wind speed maintenance time Ty1 has elapsed at the first wind speed α until a condensed film is formed on the decontamination target X. Then, the wind speed of the indoor air (including hydrogen peroxide gas) in the work space 20 is set to 0, and is maintained for a predetermined wind speed 0 maintenance time Ty2.

  As described above, even in the indoor air deceleration process in which the wind speed of the room air is changed from the first wind speed α to 0, the hydrogen peroxide gas easily enters and stays on the surface of the complicated shape of the decontamination target X. As a result, the hydrogen peroxide gas is sufficiently supplied, and the condensed film is stably formed in the details, and further maintained or grown. In such a configuration, the control device 30 is provided with the indoor air deceleration control content in which the wind speed of the room air is set to 0 from the first wind speed α.

Also in this modification, the first wind speed maintenance time Ty1 supplies the hydrogen peroxide gas into the isolator 2 by a predetermined first supply amount, and the wind speed 0 maintenance time Ty2 is equal to the second supply amount. configuration for supplying hydrogen peroxide gas into the isolator 2 is desirable.

  Further, the indoor air deceleration process described so far may be executed a plurality of times. By adopting such a configuration, the second wind speed maintenance time Tx2 (or the wind speed 0 maintenance time Ty2) comes multiple times, the maintenance or growth of the condensed film is stabilized, and the decontamination effect is improved. .

  Note that the embodiments described so far can be modified as appropriate. The configuration in which each device is controlled by the control device 30 may be realized by another configuration. For example, an operator may operate each device to control the decontamination environment. Further, the condensation of the hydrogen peroxide gas may be intentionally formed by intentionally changing the room temperature or the room humidity in the isolator 2. In addition, the optimum amount of condensation may be maintained by adjusting the room temperature or the room humidity.

1 is a schematic longitudinal sectional view of a decontamination system 1. FIG. 3 is a block circuit diagram of a control device 30. FIG. It is a timing chart figure of the decontamination method concerning this invention. It is a timing chart figure of the decontamination method concerning a modification.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Decontamination system 2 Isolator 6 Hydrogen peroxide gas generation supply device 15 Blower device 30 Control device X Decontamination target object α First wind speed β Second wind speed

Claims (2)

The decontamination gas is supplied to the decontamination chamber, and the room air containing the decontamination gas is caused to flow in the decontamination chamber by a blower provided in the decontamination chamber, so that the decontamination gas is supplied into the decontamination chamber. In the decontamination method of decontaminating the decontamination object by condensing the decontamination gas on the surface of the decontamination object in the decontamination chamber,
By controlling the blower,
The wind speed of the indoor air flowing in the decontamination chamber, until condensed film decontamination object is formed, after maintaining at a predetermined first wind speed, predetermined slow second wind speed than the first wind speed Maintaining or growing the condensed film by maintaining the air for a certain period of time or stopping the air blower and setting the wind speed of the room air to 0 for a predetermined period of time ;
In the indoor air deceleration process,
In the time maintained at the first wind speed, the decontamination gas is supplied into the decontamination chamber by the first supply amount,
Supplying the decontamination gas in a second supply amount less than the first supply amount in a time of maintaining a second wind speed slower than the first wind speed or a time in which the wind speed of the room air is zero,
The decontamination method , wherein the indoor air deceleration step is repeated a plurality of times . A decontamination chamber to which decontamination gas is supplied;
An air blower that is provided in the decontamination chamber and flows indoor air containing a decontamination gas in the decontamination chamber;
A blower control means for controlling the blower to change the wind speed of the indoor air flowing in the decontamination chamber ;
A condensation sensor that detects that the decontamination gas has condensed on the surface of the object to be decontaminated;
A decontamination gas supply device for supplying the decontamination gas to the decontamination chamber ,
The blower control means controls the blower to cause the indoor air containing the decontamination gas supplied by the decontamination gas supply device to flow in the decontamination chamber to flow the decontamination gas into the decontamination chamber. As well as
In the decontamination system for decontaminating the decontamination object by condensing the decontamination gas on the surface of the decontamination object in the decontamination chamber,
The blower control means is
The air speed of the room air flowing in the decontamination chamber is controlled at a predetermined first wind speed until the blower is controlled and the condensation sensor detects that the decontamination gas has condensed on the surface of the decontamination object. after maintaining, the slow second wind speed than the first wind speed to maintain a predetermined time or the velocity of the indoor air blower device is stopped by a predetermined time by 0, maintains the condensate film or The room air deceleration control content to grow ,
Furthermore, in the configuration comprising decontamination gas supply device control means for controlling the decontamination gas supply device and changing the supply amount of the decontamination gas,
The decontamination gas supply device control means controls the decontamination gas supply device so that the decontamination gas is supplied to the first supply amount during the time when the blower control means maintains the wind speed of the room air at the first wind speed. Only fed into the decontamination chamber,
The decontamination gas supply device control means performs the decontamination gas during the time when the air blower control means maintains the wind speed of the room air at the second wind speed slower than the first wind speed or when the air speed of the room air is zero. Controlling the supply device to supply the decontamination gas in a second supply amount less than the first supply amount;
The blower control means is
A decontamination system comprising a control content for repeating the indoor air deceleration control content a plurality of times .

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