JP4925545B2 - Adhesive material for skin application - Google Patents

Description

【００５４】
以下、表１及び図４と図５を参照しながら評価結果について考察する。
なお、図４（ａ）は、実施例１により得られた粘着部材の支持体表面を示す写真であり、図４（ｂ）は実施例５により得られた粘着部材の支持体表面を示す写真であり、図５（ａ）は比較例２により得られた粘着部材の支持体表面を示す写真であり、図５（ｂ）は比較例３により得られた粘着部材の支持体表面を示す写真である。図４（ａ）及び（ｂ）から、菱形または十文字の凹部のほぼ中央に、貫通孔が形成されている粘着剤が得られたことがわかる。一方、図５（ａ）には、菱形の凹部は形成されているが、貫通孔は形成されておらず、図５（ｂ）には、凹部も貫通孔も形成されていない粘着部材が形成されたことが分かる。
【００５５】
表１において、貫通孔を１〜２０個／１０ｍｍ²有する実施例１〜６のサンプルシートは、体内から発生した汗等を貫通孔から蒸散させることができたので、ムレを防止することができ、カブレの前兆である赤みが発生しておらず、皮膚刺激を感じなかった。また、貼着した６人全員が、角質剥離面積率は４０％以下であった。さらにまた、実施例１〜６のサンプルシートは、弾性率が低く、かつ応力緩和率も低いものであり、皮膚に貼着しても引張感が起こらなかった。さらに、実施例１〜６のサンプルシートは、十分な皮膚接着力を有しているものであり、皮膚接着力が１時間後でも６時間後でも同じで変化することはなかった。なお、実施例１〜６のサンプルシートは、凹部を有しており、手で切断することができ、特に、菱形の凹部を有する実施例１〜３のサンプルシートと、十文字形状の凹部を有する実施例５〜６のサンプルシートは、手で容易に切断することができた。したがって、本発明の皮膚貼着用粘着部材を使用すれば、ムレを防止することができ、角質の損傷を最小限に抑えることができるので、皮膚刺激に敏感な人、肌の弱い乳幼児、肌の弱っている老人、繰り返し同じ場所に粘着テープを貼着することが必要な患者等にも、安心して使用することができる。
【００５６】
一方、比較例１は、凹部は有するが貫通孔が形成されていないので、ムレが生じ、角質剥離面積率が４０％より大きくなってしまった。また、比較例２，３は、粘着剤層がゲル粘着剤ではなくアクリル系粘着であり、かつ、比較例１と同様に、貫通孔が形成されていないので、角質剥離面積率が５０％よりも大幅に大きかった。比較例３については、さらに、弾性率がやや大きいものとなっていた。比較例４は、２０個／１０ｍｍ²より多くの貫通孔が形成されているので、サンプルシートが脆くなり、また、接着力も低下して、しっかり固定することができなかった。また、比較例１〜３では、ムレにより水分が溜まり、さらに長時間貼着し続けると接着力が極端に低下することがあった。
【００５７】
【発明の効果】
以上述べたように、本発明によれば、皮膚にしっかりと貼着すると共に、体内から発生した汗等を皮膚と粘着テープとの間に閉じ込めることなく蒸発させることが可能で、かつ、皮膚に対する物理的刺激及び化学的刺激を低減することができる皮膚貼着用粘着部材を提供することができる。さらに、この皮膚貼着用部材は、確実に貫通孔が存在するので、ムレに起因する皮膚刺激を抑制してカブレ等の皮膚のトラブルを防ぐことができ、常に快適な環境下で使用できる。また、粘着部材の凹部の形状と面積、貫通孔の面積、凹部の面積と貫通孔の面積との割合等に着目して、これらを好適な範囲に設計することができるので、体内から発生した汗等を効率よく蒸散させ、ムレを生じさせず、角質損傷を引き起こさず、角質損傷による皮膚刺激を極力低減することができる。したがって、特に皮膚刺激に過敏な人に好適であり、例えば、老人、乳幼児、あるいは粘着テープを頻繁に利用する、透析患者や心臓疾患者、病弱な人等にも好適である。
【図面の簡単な説明】
【図１】（ａ）は本発明の第１の実施形態に係る皮膚貼着用部材の構成を示す平面図であり、（ｂ）は図１（ａ）における線Ａ−Ａ’で切断したときの断面図である。
【図２】本発明の皮膚貼着用粘着部材の層構成を示す断面図である。
【図３】（ａ）は本発明の第２の実施形態に係る皮膚貼着用部材の平面図であり、（ｂ）は本発明の第３の実施形態に係る皮膚貼着用粘着部材の平面図であり、（ｃ）は本発明の第４の実施形態に係る皮膚貼着用粘着部材の平面図である。
【図４】（ａ）は実施例１の粘着部材の支持体表面を示す写真であり、（ｂ）は実施例５の粘着部材の支持体表面を示す写真である。
【図５】（ａ）は比較例２の粘着部材の支持体表面を示す写真であり、（ｂ）は比較例３の粘着部材の支持体表面を示す写真である。
【符号の説明】
１ 支持体
１’ 最表面部分
２ 粘着剤層
３、１３、２３、３３ 凹部
３’ 底面部分
４、１４、２４、３４ 貫通孔
６ 背面層
７ 中間層
８ 接着層
１０ 粘着部材[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an adhesive member for skin application used in the medical field, sports field, and the like, and more particularly to an adhesive member for skin application used in medical wound adhesive plaster, hap material, dressing material, wound protection material and the like.
[0002]
[Prior art]
Bandages have been used to protect and fix gauze on surgical sutures and scratches, but in recent years, adhesive tapes have been used instead of bandages. In addition, the adhesive tape may be used by being stuck to the same site for a long time, or may be used by being repeatedly applied to the same site for regular treatment. Such an adhesive tape is required to be gentle to the skin and does not irritate the skin.
[0003]
However, the conventional pressure-sensitive adhesive tape often gives a chemical stimulus to the sticking site or gives a physical stimulus when the pressure-sensitive adhesive tape is peeled off. This may be due to the adhesive component, or may be due to the adhesive strength of the adhesive tape or the hardness of the base material. It is because it often causes. For example, when an adhesive tape with low moisture permeability is applied, sweat, sebum, or the like that is shed from the body accumulates on the applied part, causing stuffiness, keratin damage, and fogging. In addition, the damaged keratin on the skin surface caused by the swelling may be peeled off when the adhesive tape is peeled off, and the keratin damage may be enlarged. Therefore, development of an adhesive tape having moisture permeability is underway.
[0004]
Non-woven fabric, polyvinyl chloride, ethylene-vinyl acetate copolymer, polyurethane, etc. are used as the base material, and some have water permeability. In addition, acrylic, rubber, and silicone adhesives have been developed as adhesives. In recent years, adhesives that have pursued moisture permeability, and oily adhesives that have a constant adhesive force immediately after sticking are used. Gel adhesives have also been developed. However, these alone cannot achieve an appropriate water permeability and satisfy the low irritation to the skin.
[0005]
In addition, there are adhesive tapes with holes and notches, and adhesive tapes have been developed that contribute to the prevention of stuffiness due to sweating. Since it was intended to improve the performance, it did not consider skin irritation caused by stuffiness. For this reason, there are no through-holes penetrating the pressure-sensitive adhesive layer, and many holes are clogged with the pressure-sensitive adhesive.
[0006]
[Problems to be solved by the invention]
The present invention has been made to solve the above-mentioned problems, and an object of the present invention is to firmly adhere to the skin and evaporate without confining sweat generated from the body between the skin and the adhesive tape. Another object of the present invention is to provide an adhesive member for attaching to the skin, which can be reduced and can reduce physical and chemical irritation to the skin.
[0007]
[Means for Solving the Problems]
The adhesive member for skin application of the present invention is an adhesive member for skin application having a support and an adhesive layer, and is 10 mm on the surface of the adhesive member for skin application. ² It has 1 to 20 through holes per one.
Here, the through hole has an area of 0.002 mm per piece. ² ~ 0.05mm ² Can be within the range of
Moreover, a recessed part can exist in the surface of the adhesive member for skin sticking.
Further, with respect to the recesses, 50% or more of the total number of recesses can have through holes.
In addition, the shape of the concave portion may be at least one selected from the group consisting of a rhombus, a square, an ellipse, a circle, a lattice, and a cross shape.
Moreover, the said recessed part is 10 mm of the adhesive member for skin sticking. ² The total area of the recesses is 0.1 mm ² ~ 6mm ² Can be.
Also, the stress relaxation rate can be 50% or less.
The exfoliated skin exfoliated area when the adhesive member for adhering to the skin is adhered to the skin surface for 6 hours or more and then peeled off may be 40% or less of the adhered skin area.
[0008]
In the present invention, the adhesive member to be adhered to the skin is designed so that the through-holes are surely present, and an appropriate number of through-holes necessary to prevent the sticking part from becoming stuffy is designed in mind. Therefore, it is possible to prevent stuffiness of the skin at the sticking part. Therefore, it is possible to prevent keratin exfoliation and reduce skin irritation even when exfoliating the sticking member without causing keratin damage to the skin.
[0009]
DETAILED DESCRIPTION OF THE INVENTION
The adhesive member for skin sticking of this invention is a laminated body which has a support body and an adhesive layer at least, and has a through-hole. However, the through hole is 10mm of the adhesive member for skin application. ² 1-20 pieces (1-20 pieces / 10mm ² ) Is provided. Adhesive member with through-hole attached to skin 10mm ² If the ratio is less than one, the moisture cannot be sufficiently evaporated, while the number of through holes is 10 mm. ² On the other hand, when the number is more than 20, the pressure-sensitive adhesive member may become brittle or the adhesive force may be reduced. The size of the through hole is 0.002 mm when the area of one hole is ² ~ 0.05mm ² It is preferable to be within the range. If the size of the through hole is within such a range, moisture such as sweat generated from the skin can be evaporated. In this way, the adhesive member for skin application having a through-hole can evaporate from the through-hole without confining sweat or the like generated from the body between the skin and the adhesive member. It is possible to keep the sticking site comfortable and to reduce keratin damage.
[0010]
When the adhesive member is attached to the skin for a long time (for example, 6 hours or more) and then peeled off, the area of the keratin that is peeled off and attached to the adhesive member is the attached skin area (the adhesive of the adhesive member) 40% or less of the layer area), and by adopting the above configuration, the exfoliated area of the stratum corneum can be suppressed to 1% to 35%. In addition, by providing the through hole, the elastic modulus of the support base material can be reduced, and the stress relaxation rate can also be reduced. Therefore, after sticking on the skin, the tensile stress of the adhesive member is relaxed, and the burden on the skin can be reduced.
[0011]
In this invention, it is preferable that the recessed part is formed in the support body side of the adhesive member for skin sticking, The recessed part is 10 mm of the adhesive member for skin sticking. ² Total area per unit is 0.1mm ² ~ 6mm ² It is preferable to be within the range. When the concave portion is provided on the surface of the support, it can be easily cut by hand. Further, the adhesive can be prevented from protruding, and the skin follow-up property is increased and the touch is improved due to the decrease in the elastic modulus.
Of the total number of recesses formed on the adhesive member for skin application, it is preferable that 50% or more of the recesses have through holes, and more preferably that each recess has at least one through hole. Here, the total area of the through holes is preferably smaller than the total area of the recesses, and the area of one through hole is preferably smaller than the area of one recess.
[0012]
The shape of the recess is not particularly limited and can be freely designed. For example, any shape such as a rhombus, square, rectangle, ellipse, circle, lattice, or cross shape can be selected. In order to cut the adhesive member by hand, the shape of the concave portion is preferably a polygonal shape rather than a circular shape, more preferably a lattice shape, and particularly preferably a cross shape.
[0013]
Arbitrary methods can be adopted to form through holes and recesses in the adhesive member to be attached to the skin. However, using a device or the like that can simultaneously form a regular pressing die and through holes, It is preferable to form a through hole and a recess in the wearing adhesive member. Examples thereof include a hot roll method, a hot needle punching method, a laser method, a discharge machining method, a microwave method, an ion irradiation method, a static electricity method, and the like. The hot needle drilling method can be suitably used because the formation rate of the through holes is high.
[0014]
In the hot needle punching method, an apparatus having a punching roll and a receiving roll is required. As the receiving roll, for example, a receiving roll made of NBR rubber, urethane resin, iron, stainless steel, aluminum or the like is used. The perforating roll has a pin for forming a hole in the object, and in order to form a through-hole in the object, the perforation roll has an appropriate length according to the thickness of the adhesive member to be attached to the skin as the object. Preferably, the pins are selected. For example, when the thickness of the support is 60 to 100 μm and the thickness of the pressure-sensitive adhesive layer is 20 to 100 μm, the length of the pin is preferably 0.1 mm to 0.9 mm, more preferably 0. 4 mm to 0.8 mm. As the shape of the pin of the perforating roll, an arbitrary shape such as a cone, a quadrangular pyramid, a triangular pyramid or the like can be selected, but a lattice shape is preferable.
[0015]
In the thermal perforation method, it is preferable that the perforation roll and the receiving roll maintain a predetermined temperature when forming the recess and the through hole. The temperature of the punch roll is preferably in the range of 80 ° C to 250 ° C, and more preferably in the range of 150 ° C to 220 ° C. If the temperature of the perforation roll is in the range of 150 ° C. to 220 ° C., uniform concave portions and uniform through holes can be formed. The temperature of the receiving roll is preferably in the range of 40 ° C to 130 ° C, and more preferably in the range of 75 ° C to 110 ° C.
[0016]
Hereinafter, embodiments of the present invention will be described in detail with reference to the drawings. The same constituent elements are denoted by the same reference numerals, and the description thereof is omitted.
Drawing 1 is a figure showing the adhesive member for skin sticking concerning a 1st embodiment of the present invention, (a) is the top view, and (b) is the sectional view. The adhesive member for skin application according to the present embodiment has a tape shape or a sheet shape, and is used by being directly attached to the skin. Here, the adhesive member for skin affixing having a tape shape will be described.
[0017]
As shown in FIGS. 1A and 1B, an adhesive tape 10 that is a skin sticking member according to this embodiment includes a support 1 and an adhesive layer 2 laminated on the support 1. Yes. In FIG. 1A, the adhesive tape 10 has six rhombus-shaped recesses 3 arranged in two rows of three, and one through hole 4 is formed inside each recess 3. Yes. A sectional view taken along line AA ′ in this figure is shown in FIG.
[0018]
In FIG. 1B, the bottom surface portion 3 ′ of the recess 3 indicates a position lower than the outermost surface portion 1 ′ of the support 1, and a recess space is formed in the support 1. A through hole 4 is formed in the center of the bottom surface portion 3 ′ of the recessed space so as to penetrate the support 1 and the adhesive layer 2. By having the predetermined number of through-holes, sweat and the like from the skin can be evaporated through the through-holes, so that discomfort due to stuffiness and keratin damage to the skin surface can be prevented.
[0019]
Here, the support 1 may be a single layer sheet, but may be a laminate of two or more layers. In FIG. 2, the layer structure of the adhesive member for skin sticking in case the support body 1 is a laminated body of a 3 layer structure is illustrated. In FIG. 2, the support 1 is composed of a back layer 6, an intermediate layer 7, and an adhesive layer 8. The adhesive member 10 for attaching to the skin has a configuration in which the adhesive layer 2 is provided on the surface of the adhesive layer 8 of the support 1.
[0020]
In the first embodiment shown in FIG. 1, an example of the adhesive member for skin application having a rhombus shape, six recesses, and one through hole in each recess, The adhesive member for skin sticking of the aspect from which the shape and number of a recessed part and a through-hole differ is demonstrated using Fig.3 (a)-(c) which illustrated the support body surface.
Fig.3 (a) is a top view which shows the adhesive member for skin sticking which concerns on the 2nd Embodiment of this invention, and has shown the example whose shape of a recessed part is a cross shape. In the present embodiment, six concave portions 13 are arranged in two rows of three, and one through hole 14 is formed in the approximate center of the cross-shaped concave portion 13. In this way, by making the shape of the concave portion a cross-shaped, the adhesive member can be easily cut only by hand without using a cutting tool such as scissors.
[0021]
FIG.3 (b) is a top view which shows the adhesive member for skin sticking which concerns on the 3rd Embodiment of this invention. In this embodiment, the shape of the recesses 23 is a triangle, and three recesses 23 are arranged in two rows. One through hole 24 is formed in each recess 23 located in the lower part of the drawing, but two through holes 24 are formed in substantially equal positions in the upper recess 23. Thus, the number and position of the through holes can be set as appropriate.
[0022]
FIG.3 (c) is a top view which shows the adhesive member for skin sticking which concerns on the 4th Embodiment of this invention. In the present embodiment, the three concave portions are arranged in a line, and the shape of the concave portions is a star shape. The two concave portions 33 arranged on the left side are each formed with one rectangular through hole 34, but no through hole is formed in the concave portion 33 arranged on the right side. . Thus, although it is not necessary to form a through-hole in all the recessed parts, the number of through-holes is 1-20 pieces / 10mm. ² It must be designed to be
[0023]
The support constituting the adhesive member for skin application is preferably formed from a flexible and stretchable material, for example, preferably formed from a flexible and stretchable thermoplastic resin. Examples of such thermoplastic resins include ethylene-methacrylate resins, poly-α-olefin resins, ethylene-vinyl acetate resins, polyurethane resins, polyethylene resins such as low density polyethylene and linear low density polyethylene, and polypropylenes such as random polypropylene. Based resins and the like. In the present invention, in order to add flexibility, strength, and the like, different types of thermoplastic elastomers may be blended in the thermoplastic resin as a modifier. Further, in order to add flexibility, strength, etc., a plurality of layers made of resins having different crystallinity may be laminated, for example, a layer made of amorphous polyolefin resin and a layer made of polypropylene resin. May be laminated. For example, a layer made of an ethylene-propylene copolymer as the back layer in FIG. 2, a layer made of amorphous polyolefin as the intermediate layer, and an ethylene-propylene copolymer and an ethylene-butylene copolymer as the adhesive layer were blended. A three-layer structure of resin layers can be employed.
[0024]
As an amorphous polyolefin-based resin, propylene is atactically polymerized alone using a predetermined catalyst, and each monomer randomly arranges propylene and an α-olefin having 2 to 10 carbon atoms other than propylene. And those having a relatively low molecular weight. In particular, a copolymer of amorphous ethylene and amorphous propylene, a copolymer of amorphous butene-1 and amorphous propylene, or amorphous ethylene and amorphous butene A random copolymer of -1 and amorphous propylene is preferably used. In the case of a copolymer of propylene and an α-olefin other than propylene, the propylene content is 50% by weight or more, and the content of the α-olefin having 2 to 10 carbon atoms is 50% by weight or less. preferable.
[0025]
The amorphous polyolefin preferably has a number average molecular weight of 1,000 to 28,000, more preferably 1,500 to 25,000, and 2,000 to 20,000. Is particularly preferably used. As the amorphous polyolefin, those having a relatively low melt viscosity are preferably used. For example, those having a melt viscosity at 190 ° C. in the range of 100 to 100,000 Pa · s are preferable.
[0026]
Here, as the α-olefin having 2 to 10 carbon atoms, ethylene, butene-1, pentene-1, hexene-1, octene-1, nonene-1, decene-1, 4-methylpentene-1, 4 -Chain α-olefins such as methylhexene-1,4,4-dimethylpentene-1 or cyclic α-olefins such as cyclopentene. These α-olefins may be used alone, but two or more kinds may be used in appropriate combination.
[0027]
In the present invention, each layer constituting the support may contain, as necessary, commonly used additives within a range that does not impair the effects of the present invention. Additives include fillers such as talc, pigments, colorants, anti-aging agents, flame retardants, UV absorbers, antistatic agents, antioxidants, antibacterial agents, antifungal agents, lubricants, stabilizers, plasticizers Etc.
[0028]
The total thickness of the support is preferably in the range of 20 to 150 μm, more preferably 40 to 120 μm, and particularly preferably 60 to 100 μm. Further, the support preferably has a stress relaxation rate at 23 ° C. of 60% or less, and more preferably 40% or less. If the stress relaxation rate at 23 ° C. is 60% or less, the skin-adhesive adhesive member is applied to the skin, and then the skin is not pulled. If the stress relaxation rate is 40% or less, the skin irritation is prevented. No inconvenience to sensitive people.
[0029]
The pressure-sensitive adhesive layer provided on one surface of the support is preferably a layer having flexibility and viscoelasticity that can follow the attached skin, and is formed using a pressure-sensitive adhesive that is less irritating to the skin. It is preferred that In addition, the adhesive layer has an adhesive property that does not peel off from the skin surface during sticking. When peeling the pressure-sensitive adhesive member, the physical peel strength, that is, the force required for peeling from the skin. Is preferably small. This is because if the keratin on the skin surface is not damaged, it is not necessary to give an extra stimulus to the skin, and the occurrence of fog and the like can be minimized. As an adhesive, the adhesive generally used for a medical adhesive tape etc. can be used without being specifically limited. For example, an acrylic pressure-sensitive adhesive, a rubber-based pressure-sensitive adhesive, a vinyl ether-based pressure-sensitive adhesive, a urethane-based pressure-sensitive adhesive, a silicone-based pressure-sensitive adhesive or the like can be used alone or in combination of two or more. Further, as liquid components, saturated or unsaturated fatty acids obtained from natural fats and oils, monohydric or polyhydric alcohols, fatty acid esters obtained from these, fatty oil components such as aliphatic amines, etc. are mixed in an adhesive and obtained by crosslinking. The oily gel pressure-sensitive adhesive obtained can be preferably used. This oil-based gel pressure-sensitive adhesive is excellent in adhesion to the skin, and the pressure-sensitive adhesive immediately adapts to the unevenness of the skin, so that a large adhesion area can be secured immediately after application. Therefore, the adhesive force of the pressure-sensitive adhesive can be suppressed to a low level, and a certain sticking force is maintained from immediately after sticking to peeling, and a small force is required when peeling from the skin.
[0030]
As an acrylic adhesive, the homopolymer of (meth) acrylic-acid alkylester or the copolymer which has a (meth) acrylic-acid alkylester as a main component is mentioned. As a (meth) acrylic-acid alkylester, what has a C1-C18 alkyl group is preferable, and what has a C4-C12 alkyl group is still more preferable. Further, in the case of a copolymer mainly composed of (meth) acrylic acid alkyl ester, a copolymer obtained by copolymerizing another copolymerizable monomer within a range of 3 to 50% by weight, What is copolymerized within the range of 5 to 40% by weight is more preferable.
[0031]
Examples of the (meth) acrylic acid alkyl ester include butyl ester, hexyl ester, octyl ester, nonyl ester, decyl ester, lauryl ester, stearyl ester and the like. These ester chains may be linear or branched.
[0032]
Monomers copolymerizable with (meth) acrylic acid alkyl esters include unsaturated monomers containing carboxyl groups such as (meth) acrylic acid, maleic acid, fumaric acid, crotonic acid, and (meth) acrylic acid 2 -Hydroxyethyl esters, (meth) acrylic acid hydroxyalkyl esters such as (meth) acrylic acid 3-hydroxypropyl ester, (meth) acrylamides such as (meth) acrylamide and dimethyl (meth) acrylamide and their derivatives, N-butoxymethyl It contains acid amide groups such as (meth) acrylamide, N-alkoxyalkyl (meth) acrylamides such as N-ethoxymethyl (meth) acrylamide, (meth) acrylic acid N, N-alkylaminoalkyl esters, and N-vinylpyrrolidone. Functional monomers such as unsaturated monomers It is below. In addition to these functional monomers, non-functional monomers such as vinyl acetate, styrene and acrylonitrile can also be copolymerized. In addition, if necessary, an appropriate amount of a softening agent such as liquid polybutene, mineral oil, lanolin, liquid isoprene, aliphatic ester, a filler such as titanium oxide or zinc oxide, an antioxidant such as butylhydroxytoluene, Furthermore, you may mix | blend. However, when a softening agent is blended, it is preferably crosslinked with a polyfunctional polyisocyanate, a polyfunctional epoxy compound, an aluminum chelate compound, or the like.
[0033]
As rubber-based adhesive, natural rubber, polyisobutylene, polyisoprene, polybutene, styrene-isoprene block copolymer, styrene-butadiene block copolymer, etc. are used as the main polymer, and rosin resin as a tackifier , Terpene resins, coumarone-indene resins, terpene-phenol resins, petroleum resins and the like can be used. Also, as in the case of acrylic adhesives, if necessary, softening agents such as liquid polybutene, mineral oil, lanolin, liquid isoprene, aliphatic esters, fillers such as titanium oxide and zinc oxide, butylhydroxytoluene, etc. An appropriate amount of the antioxidant may be further added.
[0034]
Examples of the silicone pressure-sensitive adhesive include a pressure-sensitive adhesive mainly composed of dimethylpolysiloxane.
As an oil-based gel adhesive, the adhesive which has trioleic acid fatty acid ester as a main component is illustrated.
[0035]
In consideration of low skin irritation, it is preferable to use an acrylic pressure-sensitive adhesive. By forming an adhesive layer using an acrylic adhesive on a support having good stress relaxation properties, an adhesive member having excellent stress relaxation properties and low irritation to the skin can be realized. Moreover, when this adhesive member is perforated, the stress relaxation property is further improved, the apparent elastic modulus is reduced, and an adhesive member for skin application that easily fits the skin can be realized.
[0036]
In the present invention, the pressure-sensitive adhesive layer may be formed by directly applying the above-mentioned pressure-sensitive adhesive on a support using a solvent or the like, or by applying the pressure-sensitive adhesive to a release liner or the like, After the pressure-sensitive adhesive layer is formed in advance, this pressure-sensitive adhesive layer may be bonded to the support.
Further, the thickness of the pressure-sensitive adhesive layer is not particularly limited and can be arbitrarily set, but is generally preferably in the range of 10 to 200 μm, and preferably in the range of 20 to 100 μm. More preferably.
[0037]
The adhesive member for sticking to the skin is obtained in a sheet form, a tape form, etc., and can be stored, moved, etc., for example, wound in a roll form or with a separator overlaid on the adhesive layer. As this separator, those generally used for adhesive tapes affixed to the skin can be used. For example, the surface of high-quality paper, glassine paper, parchment paper, etc. is coated with a release material having release performance such as silicone. In addition, a surface of a high-quality paper coated with a resin anchor or a polyethylene laminated surface or the like coated with a release agent such as silicone can be used.
[0038]
The adhesive member for skin application of the present invention is used as a medical tape or sheet such as a wound adhesive bandage (surgical tape), a dressing material, or a wound adhesive bandage. For example, the adhesive member for skin application is cut to an appropriate size to form an adhesive bandage, or a covering material for covering the wound part, a post-surgical patch, a catheter needle insertion part, a cover material for gauze, etc. A medical tape or sheet can be formed, or a medical product such as a fixing tape or an instrument holding tape can be formed by combining an adhesive sheet with another substrate. Moreover, since the adhesive member for skin application of the present invention can prevent stuffiness and minimize keratinous damage to the skin, it can be used as an adhesive member for transdermal absorption preparations that require long-time application. Is also effective.
[0039]
【Example】
Examples of the present invention will be described below and will be described in more detail. However, the present invention is not limited to these examples, and various applications are possible without departing from the technical idea of the present invention. In the following, “part” means “part by weight”, and “%” means “% by weight”.
[0040]
Example 1
<Production of support>
A resin composition comprising 100% ethylene-propylene copolymer was used as the back layer, and a 50% mixture of amorphous poly α-olefin and 50 parts polypropylene homopolymer was used as the intermediate layer, and talc 40 % And a composition obtained by mixing 10% of a hydrogenated styrene-butadiene random copolymer and blending 80% of an ethylene-propylene copolymer and 20% of an ethylene-butylene copolymer as an adhesive layer. Was used. Each composition of the back layer, the intermediate layer, and the adhesive layer was put into a T-die extruder to form a laminate having a three-layer structure of back layer / intermediate layer / adhesive layer. That is, each composition of the back layer, the intermediate layer, and the adhesive layer is put into a three-layer T-die extruder, melted and mixed in each cylinder of the T-die extruder, and then cooled while being extruded from the cylinder in a three-layer state. A three-layer laminate was formed in contact with the roll. Next, this three-layer laminate was uniaxially stretched using a stretching roll, and then contacted with a cooling roll again to form a three-layer support having a thickness of 80 μm, which was wound on a roll. However, the cylinder of the T-die extruder was adjusted so that the temperature was in the range of 150 ° C to 220 ° C. Further, the thickness of the support was adjusted to 80 μm by adjusting the number of rotations of the two stretching rolls.
<Production of adhesive sheet>
On the adhesive layer surface of the obtained support, 100 parts of an acrylic resin comprising 5 parts of acrylic acid and 95 parts of isooctyl acrylate ester, 60 parts of trioleic acid fatty acid ester, D, L-α-tocopherol acetate 1.33 parts and 0.14 parts of trifunctional polyisocyanate as a cross-linking agent (referred to as “Gel 1”) are applied to form a pressure-sensitive adhesive layer having a thickness of 48 μm to form a pressure-sensitive adhesive sheet. Produced.
<Formation of recesses, etc.>
A concave portion and a through hole were formed on the support surface of the obtained pressure-sensitive adhesive sheet to produce a pressure-sensitive adhesive member. That is, a perforated roll having pins having a length of 0.4 mm to 0.8 mm is heated in a temperature range of 150 ° C. to 220 ° C., and an aluminum receiving roll is heated in a temperature range of 75 ° C. to 110 ° C. Then, the pressure-sensitive adhesive sheet obtained was sandwiched between the punch roll and the receiving roll to form a recess and a through hole. However, the length of the pin used, the temperature of the punch roll, and the temperature of the receiving roll are set as shown in Table 1, and the shape and area of the recesses and the number and area of the through holes are also set as shown in Table 1. I went there.
[0041]
Examples 2-4
In Example 1, the shape and area of the recesses and the number and area of the through holes were changed to the values shown in Table 1, except that the thickness of the pins of the punching roll and the shape of the punching extrusion part were changed. In the same manner as above, concave portions and through holes were formed on the surface of the support, and pressure-sensitive adhesive members of Examples 2 to 4 were obtained.
[0042]
Examples 5-6
In Example 1, the pressure-sensitive adhesive layer was changed to the following oil-based gel pressure-sensitive adhesive (referred to as “gel 2”), and the shape and area of the recesses and the number and area of the through holes were as shown in Table 1. In the same manner as in Example 1 except that the thickness of the pin of the perforating roll and the shape of the perforated extrusion part were changed, a concave portion and a through hole were formed on the support surface to obtain the adhesive members of Examples 5 and 6. It was.
Composition of oily gel adhesive (Gel 2):
・ 60 parts triglyceryl caprylate
・ Acrylic copolymer (isononyl acrylate / 2-methoxyethyl acrylate)
100 / part of acrylic acid / acrylic acid = 65/30/5)
・ Trifunctional isocyanate compound 0.1 parts
[0043]
Comparative Example 1
In Example 1, the shape and area of the recesses and the number and area of the through holes were changed to the values shown in Table 1, except that the thickness of the pins of the punching roll and the shape of the punching extrusion part were changed. In the same manner as described above, only the concave portion was formed on the support surface, and the adhesive member of Comparative Example 1 was formed.
[0044]
Comparative Example 2
Comparative Example 1 except that the composition of the pressure-sensitive adhesive layer in Comparative Example 1 was changed to a pressure-sensitive adhesive consisting only of an acrylic resin consisting of 5 parts of acrylic acid and 95 parts of isooctyl acrylate (referred to as “acrylic”). In the same manner, an adhesive member was formed.
[0045]
Comparative Examples 3-4
In Comparative Example 2, the pressure-sensitive adhesive member of Comparative Example 3 was formed in the same manner as Comparative Example 2 except that no recess was formed. Further, in Comparative Example 2, comparison was made except that the shape and area of the recesses and the number and area of the through holes were changed to the values shown in Table 1, except that the thickness of the pins of the perforating roll and the shape of the perforated extrusion part were changed. In the same manner as in Example 2, recesses and through holes were formed on the surface of the support, and the adhesive member of Comparative Example 4 was formed.
[0046]
The adhesive members obtained in Examples 1 to 6 and Comparative Examples 1 to 4 were each 2.5 cm × 5 cm (12.5 cm). ² ) To obtain a sample sheet. Each sample sheet of Examples 1 to 6 and Comparative Examples 1 to 4 was evaluated as follows. The results are shown in Table 1.
[0047]
<< Evaluation and Test >>
(1) Measurement of elastic modulus
Using a tensile tester “Autograph AGS-100D” manufactured by Shimadzu Corporation, the sample sheet was stretched at a tensile rate of 300 mm / min under the conditions of room temperature 23 ° C. and relative humidity 65% RH, and tensile stress. Was measured to prepare an elongation-stress curve. In the created elongation-stress curve, the slope of a straight line connecting two points of elongation of 0 mm and 2 mm was determined. The unit is N / mm ² It is.
[0048]
(2) Measurement of stress relaxation rate
Using a tensile tester “Autograph AGS-100D” manufactured by Shimadzu Corporation under the conditions of room temperature 23 ° C. and relative humidity 65% RH, the sample sheet has a tensile rate of 300 mm / min and an elongation of 10%. I pulled it to the point. The tensile stress value over time was measured, and the stress relaxation rate was determined based on the following formula. However, the initial tensile stress is shown as the maximum tensile stress value from the start of tension to 10% elongation.
Stress relaxation rate (%) = (tensile stress after 5 minutes / initial tensile stress) × 100
[0049]
(3) Evaluation of skin adhesion
A sample sheet was attached to the back of six healthy individuals by reciprocating a 1 kg roller, and the skin adhesive force was measured after a predetermined time. The predetermined time was measured for two types of 1 hour and 6 hours. However, the measurement of skin adhesive force was performed using a tensile tester “Autograph AGS-100D” manufactured by Shimadzu Corporation under conditions of a room temperature of 23 ° C. and a relative humidity of 65% RH, and a peeling speed of 300 mm / min. The tensile stress (N / 25 mm width) was measured at an angle of 180 degrees. Skin adhesion was shown as an average of 6 people.
[0050]
(4) Evaluation of exfoliation amount
Using the sample sheet after peeling used in the measurement of skin adhesive force, the amount of exfoliation was measured. That is, the sample sheet peeled from the back is immersed in keratin staining solution (Gentian Violet 1%, Brilliant Green 1%, distilled water 98%) manufactured by Wako Pure Chemical Industries, Ltd. for about 30 minutes to stain the skin keratin. went. Thereafter, the sample sheet was sufficiently washed with distilled water and then dried for 24 hours. The pressure-sensitive adhesive layer surface of the dried sample sheet was observed using a microscope, image analysis was performed, and the keratin exfoliation area ratio was calculated based on the following equation. The average value is shown in Table 1. The pressure-sensitive adhesive layer was not dyed with the dyeing solution.
Skin exfoliation area ratio (%) = (area of stained skin keratin / 12.5) × 100
[0051]
(5) Evaluation of skin irritation
The sample sheet was affixed to the inside of the lower arm of the six healthy subjects (sites susceptible to rash), left for 24 hours, and then peeled off. Whether or not the subject felt skin irritation during sticking and peeling, the state of the skin after peeling was visually observed, and a five-step evaluation was performed. The evaluation criteria are “1” when the skin after peeling is considerably reddish, and when the skin is affixed and peeled off, and when the skin is reddish and irritation is felt. “2”, “3” when slightly reddish and slightly irritated, “4” when no irritation but no irritation when peeling, “4”, no redness In addition, the case where no irritation was felt at the time of sticking or peeling was indicated by “5”.
[0052]
(6) Evaluation of hand cutting
The sample sheet was cut by hand, and the degree of cutting at that time was evaluated in four stages. In other words, the symbol “」 ”indicates that the sensor can be cut sensuously and linearly, and the symbol“ ◯ ”indicates that the substrate is smooth but partially cut in a wavy pattern. The symbol “Δ” indicates a case where it is completely cut, and the symbol “X” indicates a case where the support is extended and cut into pieces.
[0053]
[Table 1]

[0054]
Hereinafter, the evaluation results will be considered with reference to Table 1 and FIGS. 4 and 5.
4A is a photograph showing the support surface of the adhesive member obtained in Example 1, and FIG. 4B is a photograph showing the support surface of the adhesive member obtained in Example 5. 5 (a) is a photograph showing the support surface of the adhesive member obtained in Comparative Example 2, and FIG. 5 (b) is a photograph showing the support surface of the adhesive member obtained in Comparative Example 3. It is. 4 (a) and 4 (b), it can be seen that a pressure-sensitive adhesive having a through-hole formed at substantially the center of the rhombus or cross-shaped recess is obtained. On the other hand, in FIG. 5A, a diamond-shaped recess is formed, but no through hole is formed, and in FIG. 5B, an adhesive member in which neither a recess nor a through hole is formed is formed. You can see that
[0055]
In Table 1, 1 to 20 through-holes per 10 mm ² Since the sample sheets of Examples 1 to 6 were able to evaporate sweat and the like generated from the body from the through-hole, it was possible to prevent stuffiness, and redness that was a precursor of fog was not generated, I did not feel skin irritation. Moreover, all the six people who adhered were keratin exfoliation area ratios of 40% or less. Furthermore, the sample sheets of Examples 1 to 6 had a low elastic modulus and a low stress relaxation rate, and did not cause a tensile feeling even when adhered to the skin. Furthermore, the sample sheets of Examples 1 to 6 have sufficient skin adhesive force, and the skin adhesive force was the same after 1 hour and after 6 hours. In addition, the sample sheet of Examples 1-6 has a recessed part, can be cut | disconnected by hand, and has the sample sheet of Examples 1-3 which has a diamond-shaped recessed part, and a cross-shaped recessed part especially. The sample sheets of Examples 5 to 6 could be easily cut by hand. Therefore, if the adhesive member for skin application according to the present invention is used, stuffiness can be prevented and keratin damage can be minimized, so that people who are sensitive to skin irritation, infants with weak skin, It can be used with peace of mind for weakened elderly people and patients who need to apply adhesive tape to the same place repeatedly.
[0056]
On the other hand, Comparative Example 1 had a recess but no through-holes, so that stuffiness occurred and the exfoliated area ratio was greater than 40%. In Comparative Examples 2 and 3, the pressure-sensitive adhesive layer is not a gel pressure-sensitive adhesive but an acrylic pressure-sensitive adhesive, and, similarly to Comparative Example 1, no through-holes are formed. Was also significantly larger. In Comparative Example 3, the elastic modulus was slightly higher. Comparative Example 4 is 20 pieces / 10 mm ² Since more through-holes were formed, the sample sheet became brittle and the adhesive force was also lowered, so that it could not be firmly fixed. Further, in Comparative Examples 1 to 3, moisture accumulated due to the swelling, and the adhesive force may be extremely lowered when the sticking is continued for a long time.
[0057]
【Effect of the invention】
As described above, according to the present invention, while firmly sticking to the skin, it is possible to evaporate the sweat generated from the body without being trapped between the skin and the adhesive tape, and to the skin. It is possible to provide an adhesive member for skin application that can reduce physical stimulation and chemical stimulation. Furthermore, since this skin sticking member has a through-hole reliably, it can suppress skin irritation caused by stuffiness and prevent skin troubles such as blurring and can always be used in a comfortable environment. Also, paying attention to the shape and area of the concave part of the adhesive member, the area of the through hole, the ratio of the area of the concave part and the area of the through hole, etc. It can efficiently evaporate sweat and the like, does not cause stuffiness, does not cause keratin damage, and can reduce skin irritation caused by keratin damage as much as possible. Therefore, it is particularly suitable for people who are sensitive to skin irritation, and is also suitable for, for example, elderly people, infants, or dialysis patients, heart patients, sick people, etc. who frequently use adhesive tapes.
[Brief description of the drawings]
FIG. 1A is a plan view showing the configuration of a skin sticking member according to a first embodiment of the present invention, and FIG. 1B is a cross-sectional view taken along line AA ′ in FIG. FIG.
FIG. 2 is a cross-sectional view showing the layer structure of the adhesive member for skin application of the present invention.
3A is a plan view of a skin sticking member according to a second embodiment of the present invention, and FIG. 3B is a plan view of a skin sticking adhesive member according to a third embodiment of the present invention. (C) is a top view of the adhesive member for skin sticking which concerns on the 4th Embodiment of this invention.
4A is a photograph showing the support surface of the adhesive member of Example 1, and FIG. 4B is a photograph showing the support surface of the adhesive member of Example 5. FIG.
5A is a photograph showing the support surface of the adhesive member of Comparative Example 2, and FIG. 5B is a photograph showing the support surface of the adhesive member of Comparative Example 3. FIG.
[Explanation of symbols]
1 Support
1 'outermost part
2 Adhesive layer
3, 13, 23, 33 Recess
3 'bottom part
4, 14, 24, 34 Through hole
6 Back layer
7 middle class
8 Adhesive layer
10 Adhesive members

Claims (6)

A pressure-sensitive adhesive member for skin application having a support and an adhesive layer, wherein the support is formed by laminating layers of resins having different crystallinity , and the support is at least an amorphous polyolefin. a layer formed by using the system resin, and a layer made using a polypropylene resin, have recesses provided on the support surface, have the recess the support inside the bottom portion is included cage, the shape of the recess is, rhombic, tetragonal Katachi及 beauty is at least one selected from the group consisting of cross-shaped, to the skin sticking adhesive member, have a 10 mm ² per 1 to 20 of the through hole And the adhesive member for skin sticking characterized by the above-mentioned penetration hole being formed in this crevice. ^2. The adhesive member for skin application according to claim 1, wherein an area per one through hole is in a range of 0.002 mm ^{2 to} 0.05 mm ² .   The adhesive member for skin sticking according to claim 1 or 2, wherein 50% or more of the total number of the concave portions have through holes. The recess, 10 mm ² per skin sticking adhesive material, the skin sticking adhesive member of any one of claims 1 to 3, wherein the total area of the recess is 0.1mm ² ~6mm ² .   The adhesive member for skin application according to any one of claims 1 to 4, wherein the stress relaxation rate is 50% or less.   6. The skin exfoliation area when the adhesive member for skin application is applied to the skin surface for 6 hours or more and then peeled off is 40% or less of the applied skin area. The adhesive member for skin sticking of any one of Claims.

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