JP4916866B2 - Blood collection device - Google Patents

Description

  The present invention relates to a blood collection device for collecting blood in a blood bag from a needle punctured by a donor, and in particular, a blood collection device having a blood collection chamber on which the blood bag is placed and a decompression means for decompressing the blood collection chamber About.

  When blood is collected from a needle punctured by a donor into a blood collection bag, a blood collection device having a blood collection chamber on which the blood collection bag is placed so that blood is easily collected and a decompression unit for decompressing the blood collection chamber is used. (For example, refer to Patent Document 1 and Patent Document 2). By using such a blood collection device, the blood collection chamber becomes negative pressure, so that blood can easily flow even if the blood collection bag is not at a low position, and blood collection is easy.

  On the other hand, after collecting whole blood from a donor, the collected blood is separated into three types of blood products for blood transfusion, namely red blood cell concentrate (CRC), concentrated platelet (PC) and platelet poor plasma (PPP) by centrifugation. Bag systems are known.

  In such blood products for blood transfusion, in order to prevent various post-transfusion side effects induced by the contamination of leukocytes, leukocytes are removed from the blood for transfusion that has been separated and stored immediately before transfusion to the patient. Has been done.

  In addition, blood obtained by blood donation improves the quality of the blood product for transfusion by removing leukocytes before separation and storage. Therefore, in order to enable the removal of leukocytes before such separation and storage of blood, a pre-storage leukocyte removal bag system (in-line filter) in which a blood collection bag and a circuit including a leukocyte removal filter are connected and integrated is provided. Has been developed. In the pre-storage leukocyte removal bag system, blood is first collected in a blood collection bag, and then the blood from which the white blood cells and platelets have been removed from the blood collection bag through a leukocyte removal filter is introduced into the collection bag by opening a predetermined opening / closing means.

Japanese Patent Publication No. 5-54993 Japanese Examined Patent Publication No. 6-53158

  By the way, in the pre-storage leukocyte removal filter system, it is preferable that a predetermined amount of gas (air or the like) is sealed in advance in the collection bag so that blood can be easily led to the leukocyte removal filter and the collection bag after blood collection. This sealed gas acts to push the internal blood toward the leukocyte removal filter and collection bag, and almost no blood remains in the collection bag without any blood remaining in the leukocyte removal filter or tube in the middle. It can be transferred and is suitable.

  However, the gas sealed in the blood collection bag works favorably when extracting the collected blood, but conversely inhibits the introduction of blood to some extent during blood collection. That is, since a predetermined amount of gas is introduced into the blood collection bag in advance, the internal pressure is likely to increase due to the introduction of blood, the blood collection speed is slowed, and the blood collection time is prolonged.

  In addition, it is necessary to keep the blood collection chamber at a sufficiently low pressure (a negative pressure with a large absolute value) so that the collected blood does not flow backward when the pressure in the blood collection bag becomes high. In this case, the tip of the punctured needle may be attracted to the blood vessel wall, and the blood collection speed will be slow. That is, it is preferable to set the pressure in the blood collection chamber to a pressure suitable for blood collection, and when the blood starts to flow backward due to an unexpected situation, the phenomenon is detected quickly and a predetermined response process is performed.

  The present invention has been made in consideration of such problems, and an object of the present invention is to provide a blood collection device that easily collects blood even when the pressure in the blood collection bag increases.

  Another object of the present invention is to provide a blood collection apparatus that can quickly and easily detect the phenomenon when blood starts to flow backward during blood collection.

  A blood collection device according to the present invention is a blood collection device for collecting blood into a blood bag from a needle punctured by a donor, a blood collection chamber in which the blood bag is placed, a decompression means for decompressing the blood collection chamber, A pressure detecting means for detecting a negative pressure in the blood collecting chamber; a blood collecting amount detecting means for detecting a blood collecting amount collected in the blood bag; and the pressure reducing means based on the blood collecting amount obtained from the blood collecting amount detecting means. A control unit that controls and adjusts the negative pressure, and the control unit holds a threshold value that is set so that an absolute value increases in response to an increase in the blood sampling amount, and sets the negative pressure The decompression means is controlled so that the value is equal to or greater than the threshold value.

  In this way, by controlling the decompression means so that the set value of the negative pressure in the blood collection chamber is equal to or greater than the threshold set so that the absolute value increases in response to the increase in the amount of blood collected, Even when the pressure increases, blood is easily collected.

  In this case, an alarm is generated when it is detected that the blood collection amount obtained from the blood collection amount detecting means is decreasing, and / or the backflow blocks the part of the tube connecting the needle and the blood bag. You may have a judgment part.

  The threshold value may be set to 0 when the blood collection amount is smaller than a predetermined value.

  If the absolute value of the threshold value is set larger than the pressure in the blood bag corresponding to the blood collection volume, blood backflow can be prevented more reliably.

  The threshold value can more reliably prevent the backflow of blood, whose absolute value is set to be greater than the compensation pressure than the pressure in the blood bag corresponding to the blood collection volume.

  The present invention is a blood collection device for collecting blood into a blood bag from a needle punctured by a donor, the blood collection chamber on which the blood bag is placed, a decompression means for decompressing the blood collection chamber, and the blood bag A blood collection amount detecting means for detecting the collected blood collection amount, a control section for adjusting the negative pressure by controlling the decompression means based on the blood collection amount obtained from the blood collection amount detection means, and the blood collection amount detection means And a backflow determination unit that issues a warning when it is detected that the amount of blood collected obtained from is reduced and / or closes a part of a tube connecting the needle and the blood bag. And

  Thus, according to the backflow determination unit, it is possible to quickly and easily detect that the blood has started to flow back at the time of blood collection based on the decrease in the amount of blood collected. Necessary processing can be performed quickly.

  According to the blood collection device of the present invention, blood is controlled by controlling the decompression means so that the negative pressure in the blood collection chamber is equal to or greater than a threshold set so that the absolute value increases in response to an increase in the amount of blood collected. Even when the pressure in the bag increases, blood is easily collected.

  In addition, according to the blood collection apparatus of the present invention, it is possible to quickly and easily detect that blood has started to flow backward during blood collection based on the decrease in the amount of blood collected, such as an alarm or a tube blockage. The necessary processing can be performed quickly.

  Hereinafter, embodiments of the blood collection device according to the present invention will be described with reference to FIGS.

  As shown in FIG. 1, a blood collection device 10 according to the present embodiment collects blood using a blood collection processing set 12.

  First, the blood collection processing set 12 will be described. The blood collection processing set 12 is a so-called pre-storage leukocyte removal bag system.

  As shown in FIG. 2, the blood collection processing set 12 includes a blood collection needle 14 for puncturing a donor, and a blood collection bag (blood bag) 18 connected to the blood collection needle 14 through a blood collection tube 16. The blood collection tube 16 is provided with a hub 22 for connecting the blood collection needle 14. The blood collection bag 18 is a bag for temporarily storing blood collected from the blood collection needle 14, and an anticoagulant is enclosed therein.

  The blood collection processing set 12 includes a leukocyte removal filter 24 having one end connected to the blood collection bag 18 via the processing tube 20, and blood connected to the other end of the leukocyte removal filter 24 via the tube 26. And a processing tool 28. The blood processing instrument 28 is used for separating blood into a plurality of blood components and collecting a desired blood component in a bag from among them, and a first processing bag (red blood cell bag) for storing the blood components. 30, a second processing bag (plasma bag) 32, and a third processing bag (red blood cell storage solution containing bag) 34.

  The first processing bag 30 is connected to the leukocyte removal filter 24 via the tube 26. The tube 36 having one end connected to the first processing bag 30 is bifurcated through the branch connector 38 at the other end, and the second processing bag 32 and the third processing bag 34 are connected in parallel.

  The leukocyte removal filter 24 may be replaced with a filter that removes a macroaggregate (fine aggregate), virus, endotoxin, bacteria, prion, pathogen, or the like, or may be connected in series.

  In the third processing bag 34, an erythrocyte preservation solution is sealed in advance. This erythrocyte preservation solution is usually a liquid, and examples thereof include a SAGM solution, an OPTISOL solution, and a MAP solution. The amount of the red blood cell storage solution in the third processing bag 34 is set to an appropriate amount according to the planned blood collection amount.

  A clamp 37 is provided in the middle of the tube 26 to close the tube 26. The blood collection processing set 12 is sterilized in advance using γ rays or the like.

  In such a blood collection processing set 12, first, after collecting blood in the blood collection bag 18 using the blood collection device 10, the blood collection tube 16 is closed by a predetermined method, and the clamp 37 is opened, whereby the blood collection bag 18. The blood inside is removed through the leukocyte removal filter 24 to remove leukocytes and platelets and collected in the blood processing device 28. At this time, it is preferable that all the blood in the blood collection bag 18 is introduced into the blood processing instrument 28, and for this reason, the processing tube 20 and the leukocyte removal filter 24 need to be replaced with air. Therefore, a gas (air or the like) corresponding to the volumes of the processing tube 20 and the leukocyte removal filter 24 is enclosed in the blood collection bag 18 in advance.

  Next, the blood collection device 10 will be described. In the following description, in order to facilitate understanding, the pressure and the set value thereof will be described based on absolute values of both positive pressure and negative pressure. In other words, when the pressure is close to vacuum, the pressure (negative pressure) is expressed as high. In comparison between negative pressures, the pressure close to the vacuum (high negative pressure) is assumed to be high. Boosting and vice versa. 6 and 8 which will be described later also show that the pressure (negative pressure) is higher from the origin to the upper side.

  As shown in FIGS. 1 and 3, the blood collection device 10 has a box shape and includes a main body 50 and a transparent cover 52 that opens and closes the upper surface of the main body 50. A power switch 54 is provided in the lower front portion of the main body 50, and an operation panel 62 is provided in the upper front portion. Inside the main body 50 (see FIG. 4), a mechanism unit 58, a control unit 60, and a decompression pump (decompression unit) 61 are provided.

  The operation panel 62 includes a start switch 62a for starting blood collection, a stop switch 62b for stopping blood collection, a mixing switch 62c for mixing, a blood collection selection switch 62d for selecting a blood collection volume, a monitor 62e for displaying the blood collection volume, and the like. Yes.

  On the upper surface of the main body 50, a blood collection processing set 12, that is, a tray 64 on which the blood collection bag 18, the leukocyte removal filter 24 and the blood treatment instrument 28 are placed is provided. The tray 64 is provided with a lever 64a for stably mounting the blood processing instrument 28.

  The place where the tray 64 is provided becomes a substantially closed space when the cover 52 is closed, and constitutes a blood collection chamber 66. The tray 64 is set slightly smaller than the blood collection chamber 66 in plan view.

  A seal 68 is provided around the upper surface of the main body 50 at a position where it abuts on the lower surface of the cover 52, and the blood collection chamber 66 is configured to be substantially airtight when the cover 52 is closed.

  Above the operation panel 62 in the main body 50, a lock mechanism 69 that engages with the handle portion 52 a of the cover 52, a tube passage 72 through which the blood collection tube 16 passes, and a clamp 74 that closes the blood collection tube 16 in the tube passage 72. And a clamp lever 76 for closing the clamp 74 and a clamp release lever 78 for opening the clamp 74 in the closed state.

  As shown in FIG. 4, the mechanism portion 58 is provided below the tray 64 in the blood collection chamber 66. The mechanism unit 58 includes a motor block 80 and a swing block 82. The motor block 80 includes a motor 84 as a drive unit composed of a stepping motor, and a motor pulley 86 fixed to the rotation shaft of the motor 84.

  The swing block 82 includes an eccentric shaft 92 pivotally supported by a bearing 90, a drive pulley 94 fixed to the eccentric shaft 92, an XY swing portion 96 provided on the upper portion of the eccentric shaft 92, and the XY swing. And a parallel link member 98 connected to the upper part of the moving part 96. A timing belt 100 is wound around the motor pulley 86 and the drive pulley 94, and the drive pulley 94 is driven to rotate under the rotating action of the motor pulley 86. The parallel link member 98 is connected to the XY swing part 96 by a bracket 98a at one end and is connected to the tray 64 by a bracket 98b at the other end.

  The XY swinging part 96 is a mechanism for swinging the parallel link member 98 in the XY direction as the eccentric shaft 92 rotates, and moves in the Y-axis direction with respect to the swinging base 102 and the swinging base 102. A Y-axis slider 104 that moves and an X-axis slider 106 that moves in the X-axis direction.

  The parallel link member 98 is formed in a shape that can be slightly deformed by the weight of the blood as blood is collected in the blood collection bag 18, and a strain gauge (blood collection amount detecting means) is provided at the deformed portion. ) 108 is provided. In the vicinity of the drive pulley 94, there is provided a rotation sensor 110 for detecting a part of the drive pulley 94 protruding in the radial direction in a non-contact manner. A pressure sensor 112 that detects the pressure in the blood collection chamber 66 is provided in the vicinity of the mechanism unit 58. Since the blood collection chamber 66 has a negative pressure, the pressure sensor 112 is of a type capable of detecting a negative pressure.

  According to such a mechanism portion 58, the tray 64 performs an arc motion with a radius E to the extent that the tray 64 does not hit the wall surface of the blood collection chamber 66 under the rotating action of the motor 84. The bracket 98b fixed at the right side surface portion of the parallel link member 98 has a function of absorbing vibration by finely moving up and down while maintaining a horizontal state.

  A control chamber 122 is formed below the partition plate 120 below the blood collection chamber 66. In the control chamber 122, a control unit 60 and a decompression pump 61 are provided. The decompression pump 61 is connected to the blood collection chamber 66 by a conduit 124 and can be operated under the action of the control unit 60 to decompress the blood collection chamber 66. The conduit 124 is provided with an exhaust solenoid (pressure reducing means) 126. Under the action of the exhaust solenoid 126, air is introduced into the conduit 124 and the blood collection chamber 66 which are in a negative pressure to reduce the pressure. Can be made.

  As shown in FIG. 5, the control unit 60 is connected to the strain gauge 108, the rotation sensor 110 and the pressure sensor 112, and the blood collection amount W in the blood collection bag 18 placed on the tray 64 and the eccentric shaft 92. The rotational speed N and the negative pressure P in the blood collection chamber 66 can be detected. The control unit 60 is further connected to the decompression pump 61, the exhaust solenoid 126, the clamp 74 and the motor 84 via drivers 130, 132, 134 and 136.

  With such a connection configuration, the control unit 60 operates the decompression pump 61 to further increase the negative pressure P based on the blood collection amount W and the negative pressure P, or operates the exhaust solenoid 126 to operate the negative pressure P. Can be stepped down. The negative pressure P is adjusted by comparing the value of the negative pressure P detected by the pressure sensor 112 with the control pressure Pc by the blood collection chamber pressure control unit 140, and turning the driver 130 and the driver 132 on and off by the control unit 60. This is done by controlling the decompression pump 61 and the exhaust solenoid 126.

  The drive of the decompression pump 61 may be an on / off operation or a proportional operation by control such as PWM. The exhaust solenoid 126 may be replaced with a predetermined proportional valve to perform proportional opening control.

  Further, the control unit 60 can appropriately rotate the eccentric shaft 92 while referring to the rotation speed N obtained from the rotation sensor 110, swing the tray 64, and mix the blood and the anticoagulant. Furthermore, the control unit 60 can stop the blood collection by operating the clamp 74 to close the blood collection tube 16 as necessary. That is, the clamp 74 is configured to be automatically operated from the control unit 60 and to be manually operated by the clamp lever 76 and the clamp release lever 78.

  The control unit 60 is connected to the operation panel 62, and can input an operator's operation and reflect it in the control of the decompression pump 61 and the like, and can display information such as the blood collection amount W on the monitor 62e. The control unit 60 is connected to the buzzer 138, and can buzz the buzzer 138 in various patterns as required.

  The control unit 60 includes a CPU, ROM, RAM, input / output interface, timer, and the like (not shown), and various operations are performed by software processing in which the CPU reads and executes a program from a predetermined storage unit.

  Examples of the software processing of the control unit 60 include a blood collection chamber pressure control unit 140, a swing control unit 142, a flow rate calculation unit 144, a backflow determination unit 146, and a threshold determination unit 148.

  The blood collection chamber pressure control unit 140 sets a control pressure Pc that is a target command value of the negative pressure P based on the blood collection amount W and the blood collection speed V, and controls the decompression pump 61 and the exhaust solenoid 126 via the drivers 130 and 132. Then, the negative pressure P is adjusted. Specifically, at the start of blood collection, the control pressure Pc is increased to a predetermined pressure, and then lowered or raised appropriately based on the blood collection speed V.

  That is, when the blood collection speed V is smaller than the predetermined value V0, the control pressure Pc and the negative pressure P are set higher than appropriate values for the donor, and blood is sucked excessively. It is considered that the tip is close to or stuck to the blood vessel wall and the suction resistance is increased. Therefore, in such a state, the exhaust solenoid 126 is opened, the control pressure Pc is slightly lowered, and the blood collection speed V is optimized. In the blood collection chamber pressure control unit 140, for example, the control pressure Pc is controlled based on the blood collection speed V so as to become the pressure P1, the pressure P2, and the pressure P3 in descending order of absolute values (see FIG. 6). The pressure P1 is a maximum pressure in a range suitable for promoting blood collection, and is set to, for example, about −24 kPa.

  In the blood collection device 10, by making the inside of the blood collection chamber 66 negative in this way, blood is easily introduced into the blood collection bag 18 even when the height difference between the blood collection location and the blood collection device 10 is small, and the blood collection time is reduced. Can be shortened.

  The swing control unit 142 adjusts the rotational speed N of the eccentric shaft 92 based on the signal from the rotation sensor 110.

  The flow rate calculation unit 144 calculates a blood collection speed V that causes the blood collection volume W to flow into the blood collection bag 18 or to flow backward from a change every predetermined minute time. The backflow determination unit 146 generates an alarm sound from the buzzer 138 and displays a warning on the monitor 62e when it detects that the blood collection speed V is negative and the blood collection amount W is decreasing. At the same time, the clamp 74 is driven to close the blood collection tube 16 and the decompression pump 61 and the motor 84 are stopped to stop the blood collection chamber pressure control and the tray 64 swing control.

  The threshold determination unit 148 is a functional unit that prevents backflow of blood. Specifically, the threshold determination unit 148 corrects the control pressure Pc during blood collection according to an increase in the pressure (negative pressure) Pb in the blood collection bag 18, The negative pressure P that is the suction pressure has a function of maintaining a pressure that does not become lower than the pressure Pb and the drop pressure.

  The threshold determination unit 148 compares the value of the threshold data 148a corresponding to the blood collection amount W with the control pressure Pc, and when the control pressure Pc is lower than the threshold T, the threshold T is substituted for the control pressure Pc. The decompression pump 61 is controlled by the blood collection chamber pressure control unit 140. The threshold data 148a is set corresponding to the blood collection amount W and is represented by a map format or an empirical formula.

  As shown in FIG. 6, the threshold value T is set so that the absolute value increases in response to the increase in the blood collection amount W, and is 0 when the blood collection amount W is smaller than a predetermined value W0. The pressure is set to be larger than the pressure Pb in the blood collection bag 18 according to the blood collection amount W. Specifically, the pressure Pb is higher than the pressure Pb at the time of the predetermined value W0 and the blood collection amount We at the end by the compensation pressure Pw. It is set as a straight line. The compensation pressure Pw is set to a value at which blood can be continuously collected even when the device is arranged at the same height as the puncture site of the donor or at a certain level.

  At the start of blood collection, the pressure Pb in the blood collection bag 18 is almost zero, but since the gas is enclosed in the blood collection bag 18, the gas is compressed as the blood collection amount W increases, Pb gradually increases from the predetermined value W0.

  On the other hand, the control pressure Pc may be lowered to the pressure P2 or P3 under the action of the blood collection chamber pressure control unit 140. For example, as shown in FIG. 6, when P = P2, P (= P2) < When the pressure in the blood collection bag 18 becomes higher than the control pressure Pc (see the hatched portion 150 in FIG. 6), the suction force due to the negative pressure P does not act. Even if the set value of the control pressure Pc in the blood collection chamber 66 is P2 and P (= P2)> Pb, the pressure in the blood collection bag 18 increases as Pb increases and the blood collection speed V decreases. As a result, the negative pressure P, which is the actual suction pressure, decreases to P <Pb (see the cross-hatching portion 152 in FIG. 6), and the substantial suction force may not work.

  In such a case, there is a concern that the pressure in the blood collection bag 18 flows backward depending on the difference in height between the blood collection location and the blood collection device 10. Therefore, in order to prevent the backflow of blood, the control pressure Pc is adjusted under the action of the threshold value determination unit 148, and control is performed so as not to become smaller than the threshold value T.

  Note that the threshold value T is not limited to a linear value, and may be set in a stepped manner with predetermined values W0 and W1 as in the threshold value T1, may be in a multi-stepped shape, or set in a curved shape. May be. The pressure Pb in the blood collection bag 18 can be obtained by experiments, calculations, simulations, or the like, and the threshold T is preferably set to a value (T> Pd + Pw) that is at least greater than the pressure Pb by the compensation pressure Pw. Further, since the control pressure Pc is controlled in the range from the pressure P1 to the pressure P3, the threshold T is set to a value smaller than the pressure P1.

  Next, the operation of the blood collection apparatus 10 configured as described above will be described with reference to FIGS. Prior to processing in the blood collection device 10 of FIG. 7, predetermined preparations are made. That is, the blood collection bag 18, the leukocyte removal filter 24, and the blood processing instrument 28 are placed on the tray 64, the blood collection tube 16 is passed through the tube passage 72, the cover 52 is closed and the lock mechanism 69 is locked, and the blood collection chamber 66 is hermetically sealed. The blood collection needle 14 is punctured into the donor's blood vessel.

  First, in step S1 of FIG. 7, the power switch 54 is turned on to perform predetermined initial processing. That is, the input / output interface and the drivers 130, 132, 134, 136 are initialized, and the operation conditions such as the target blood collection amount We are read from the operation panel 62.

  In step S2, the blood collection process is started by pressing the start switch 62a. That is, the motor 84 is driven to start swinging the tray 64, the control pressure Pc is set to the pressure P1, and the decompression pump 61 is driven so that the negative pressure P in the blood collection chamber 66 becomes the pressure P1. Set and control (see line 160 in FIG. 8).

  In step S <b> 3, the blood collection amount W introduced into the blood collection bag 18 is detected based on the signal obtained from the strain gauge 108. As a unit of blood collection amount W, weight [g], volume [cc] or the like may be used.

  In step S4, the blood collection speed V is calculated from the amount of change of the obtained blood collection volume W every minute time.

  In step S5, the backflow is detected based on the fact that the blood collection speed V is negative and the blood collection amount W is decreasing. When the backflow is detected, the process proceeds to step S6, and when it is not detected, the process proceeds to step S7.

  In step S6, an alarm sound is emitted from the buzzer 138, and the clamp 74 is driven to close the blood collection tube 16. Blood collection may be stopped by this process, or blood collection may be resumed from an appropriate location after a predetermined return process by the operator.

  As described above, based on the decrease in the blood collection amount W, it is possible to quickly and easily detect that the blood has started to flow backward during the blood collection, and necessary processing such as an alarm or blockage of the tube (step S6). ) Can be done quickly.

  In step S7, the blood collection speed V is compared with a predetermined value V0. If V <V0, the process proceeds to step S8, and if V ≧ V0, the process proceeds to step S9.

  In step S8, the control pressure Pc is set one step lower. That is, when the set pressure is the pressure P1, the pressure is reduced to the pressure P2 (see the line 162 in FIG. 8), and when the set pressure is the pressure P2, the pressure is lowered to the pressure P3 (see the line 164 in FIG. 8). When the set pressure is the pressure P3, the state is maintained as it is.

  As described above, when the blood collection speed V is lower than the predetermined value V0, it is considered that the suction resistance at the tip of the blood collection needle 14 is large. Therefore, the exhaust solenoid 126 is opened to slightly lower the control pressure Pc. Therefore, it is possible to optimize the blood collection speed V. Thereafter, the process proceeds to step S11.

  In step S9, the blood collection speed V is compared with the predetermined value V1, and when V> V1, the process proceeds to step S10, and when V ≦ V1, the process proceeds to step S11. The predetermined value V1 is slightly larger than the predetermined value V0, and an operation hysteresis is obtained.

  In step S10, the control pressure Pc is set one step higher. That is, when the set pressure is the pressure P3, the pressure is increased to the pressure P2 (see the two-dot chain line 166 in FIG. 8), and when the set pressure is the pressure P2, the pressure is increased to the pressure P1 (see the two-dot chain line 168 in FIG. 8). When the set pressure is the pressure P1, the state is maintained as it is.

  As described above, when the blood collection speed V is higher than the predetermined value V1, it is considered that the suction resistance is small. Therefore, the decompression pump 61 is driven to slightly increase the control pressure Pc, and the blood collection speed V is increased. The blood collection time is shortened by raising the blood collection time.

  In step S11, a threshold T corresponding to the blood collection amount W at that time is obtained. That is, the threshold value T is obtained by referring to the threshold value data 148a using the blood collection amount W as a parameter.

  In step S12, the control pressure Pc is compared with the threshold value T. When P <T, the process proceeds to step S13, and when P ≧ T, the process proceeds to step S14.

  In step S13, the control pressure Pc is set / restricted to the threshold value T.

  According to such processing, when the blood collection amount W is W <W0, the control pressure Pc is not affected and maintains the value. When the blood collection amount W is W0 ≦ W <W1 and the negative pressure P is set to the pressure P3, the control pressure Pc is limited by the threshold T. Further, when the blood collection amount W is W1 ≦ W <We and the control pressure Pc is set to the pressure P3 or P2, the control pressure Pc is limited by the threshold T.

  Therefore, the control pressure Pc is set lower than the pressure Pb in the blood collection bag 18 by at least the compensation pressure Pw. Even if the negative pressure P, which is the actual suction pressure, decreases, the state of P> Pb The blood backflow from the blood collection bag 18 can be prevented.

  In step S14, it is confirmed whether or not a predetermined blood collection amount We (for example, 200 cc or 400 cc) has been obtained. When the blood collection amount We has not been obtained, the process returns to step SS3 to continue blood collection, and when it has been obtained, the process proceeds to step S15.

  In step S15, blood collection termination processing is performed. That is, the clamp 74 is driven to close the blood collection tube 16, the motor 84 and the decompression pump 61 are stopped, and a buzzer 138 emits a sound indicating the end.

  Thereafter, the blood collection needle 14 is removed from the donor, the blood collection needle 14 is inserted into the hub 22, and the blood collection tube 16 is closed by a predetermined closing means. The closing means may be provided on the hub 22. Further, the cover 52 is opened, the blood collection processing set 12 is taken out, and the clamp 37 is opened. As a result, the blood collected in the blood collection bag 18 passes through the processing tube 20 and the leukocyte removal filter 24, and the leukocytes and platelets are removed and introduced into the blood processing instrument 28. Since a predetermined amount of gas is sealed in the blood collection bag 18 in advance, the blood led out of the processing tube 20 and the leukocyte removal filter 24 is replaced with the gas, and almost all blood is blood processing equipment. 28.

  As described above, according to the blood collection device 10 according to the present embodiment, the control pressure Pc, which is the target command value of the negative pressure P in the blood collection chamber 66, increases in absolute value in response to the increase in the blood collection amount W. By controlling the decompression pump 61 so as to be equal to or higher than the threshold value T set to do so, blood is easily collected even when the pressure Pb in the blood collection bag 18 is increased.

  Further, according to the blood collection device 10, it is possible to quickly and easily detect that the blood has started to flow backward at the time of blood collection based on the decrease in the blood collection amount W, and it is necessary to provide an alarm or a tube blockage. Can be performed quickly.

  The blood collection device according to the present invention is not limited to the above-described embodiment, and it is needless to say that various configurations can be adopted without departing from the gist of the present invention.

It is a perspective view of the blood collection apparatus which concerns on this Embodiment. It is a top view of a blood collection processing set. It is a perspective view of the blood collection apparatus with which the blood collection processing set was mounted. It is a schematic sectional side view of a blood collection device. It is a block block diagram of a blood collection device. It is a graph which shows the relationship between blood collection volume and negative pressure. It is a flowchart which shows the procedure of the blood collection process performed with a blood collection apparatus. It is explanatory drawing which shows the state in which a negative pressure is restrict | limited based on a threshold value in the blood collection process performed with a blood collection apparatus.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 ... Blood collection apparatus 12 ... Blood collection processing set 14 ... Blood collection needle 16 ... Blood collection tube 18 ... Blood collection bag 24 ... Leukocyte removal filter 28 ... Blood treatment instrument 30, 32, 34 ... Processing bag 60 ... Control part 61 ... Pressure reduction pump 64 ... Tray 66 ... Blood collection chamber 74 ... Clamp 110 ... Rotation sensor 112 ... Pressure sensor 126 ... Exhaust solenoid 140 ... Blood collection chamber pressure control unit 142 ... Swing control unit 144 ... Flow rate calculation unit 146 ... Backflow judgment unit 148 ... Threshold judgment unit 148a ... Threshold data P ... Negative pressure Pb ... Pressure in blood bag Pc ... Control pressure Pw ... Compensation pressure T, T1 ... Threshold value W ... Blood sampling volume

Claims (6)

A blood collection device for collecting blood into a blood bag from a needle punctured by a donor,
A blood collection chamber in which the blood bag is placed;
Decompression means for decompressing the blood collection chamber;
Pressure detecting means for detecting a negative pressure in the blood collection chamber;
A blood collection amount detecting means for detecting a blood collection amount collected in the blood bag;
A control unit that controls the decompression unit based on the blood collection amount obtained from the blood collection amount detection unit to adjust the negative pressure;
Have
The control unit holds a threshold set so that an absolute value increases in response to an increase in the blood collection amount when the blood collection amount is equal to or greater than a predetermined value greater than zero , and the set value of the negative pressure is A blood collecting apparatus that controls the decompression means so as to be equal to or greater than the threshold value. The blood collection device according to claim 1, wherein
A backflow determination unit that issues a warning when detecting that the blood collection amount obtained from the blood collection amount detecting means is decreasing and / or closes a part of a tube connecting the needle and the blood bag; A blood collection apparatus comprising: The blood collection device according to claim 1 or 2,
The threshold value, blood collection device, characterized in that it is set to 0 when the blood amount is smaller than the predetermined value. The blood collection device according to any one of claims 1 to 3,
The blood collecting apparatus according to claim 1, wherein the threshold value is set to have an absolute value larger than a pressure in the blood bag corresponding to the blood collection amount. The blood collection device according to any one of claims 1 to 4,
The blood collecting apparatus according to claim 1, wherein the threshold value is set such that the absolute value is greater than the compensation pressure than the pressure in the blood bag corresponding to the blood collection amount. A blood collection device for collecting blood into a blood bag from a needle punctured by a donor,
A blood collection chamber in which the blood bag is placed;
Decompression means for decompressing the blood collection chamber;
A blood collection amount detecting means for detecting a blood collection amount collected in the blood bag;
A control unit for adjusting the negative pressure by controlling the decompression unit based on the blood collection amount obtained from the blood collection amount detection unit;
A backflow determination unit that issues a warning when detecting that the blood collection amount obtained from the blood collection amount detecting means is decreasing, and / or closes a part of a tube connecting the needle and the blood bag; ,
A blood collection device comprising:

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