JP4854190B2 - Swelling feeling improver - Google Patents

Description

  The present invention relates to a swelling-improving agent that improves a spontaneous swelling feeling that occurs in daily life and a food for improving swelling feeling. In addition, the food / beverage products of this invention point out all the articles | goods ingested orally, and food, a pharmaceutical, a quasi-drug, etc. are contained.

  It is well known that standing or sitting for a long time in daily life generates a naturally occurring swelling that is not pathological. This swelling may sometimes be felt as if the local area of the body is swollen, but in many cases, it is accompanied by transient symptoms on the body, such as actually making it difficult for shoes to wear or clothing to bite into the skin. The cause of such spontaneous swelling is thought to be mainly due to fluid leakage from the capillary blood vessels and imbalance between fluid collection by veins and lymphatic system.

  As a method for improving such swelling, for example, a foot massage device (see Patent Literatures 1 to 3), a foot warmer (see Patent Literature 4), an adhesive (see Patent Literatures 5 and 6), a stocking ( Development of socks (see Patent Documents 7 and 9) and the like have been developed, but these all improve the feeling of swelling due to stimulation from outside the body. Moreover, as a method of improving the feeling of swelling by eating and drinking, for example, the development of a swelling improving agent (see Patent Documents 10 and 11), a food composition (see Patent Document 12) and the like have been carried out, but the effect, safety, and flavor are being developed. It has not been widely used due to restrictions such as.

Patent No. 2121830 JP-A-10-15025 JP-A-11-197209 JP-A-8-28966 JP-A-8-98868 JP-A-10-279473 JP-A-9-195104 JP-A-9-273002 JP-A-9-111504 JP-A-10-218777 JP 2004-35425 A JP 2002-330728 A

  An object of the present invention is to find and provide a plant extract having an effect of improving swelling.

  Therefore, the present inventors have focused on food materials that have been eaten and eaten for a long time and have studied variously using the effect on swelling feeling as an index. Hihatsu is excellent in improving the spontaneous swelling feeling caused by eating and drinking. As a result, the present invention has been completed.

  That is, the present invention provides a swelling sensation improving agent containing hihatsu and / or an extract of hihatsu as an active ingredient. Moreover, this invention provides the food / beverage for a feeling of swelling which contains a hihatsu and / or hihatsu extract as an active ingredient.

  As described above, according to the present invention, it is possible to improve the feeling of swelling by a simple method, and it is possible to provide a food for improving the feeling of swelling that is excellent in safety and flavor.

  Hibatsu used in the present invention has been used as a spice for a long time, but its use in Japan is about the level of gastrointestinal drugs, it is hardly used for foods, and there is no known improvement in the feeling of swelling due to eating and drinking. It was.

  Hihatsu is also called Naga pepper, and can use the fruit head portion of a plant derived from Pepper longum or Pipe retrofactum.

  Hibachi fruit ears may be used as they are, but may be used after performing operations such as pulverization and extraction as necessary. In the extraction of baboon, a solvent used for the extraction of food and drink can be used. For example, a hydrophilic organic solvent such as water or alcohol or a hydrophobic organic solvent such as hexane is used, and a conventional plant extract is manufactured. It is only necessary to perform the extraction operation.

  In order to use the cherries and / or cherries extract for the swelling feeling improving agent, the cherries and / or cherries are used alone or sugars such as glucose, fructose, sucrose, dextrin and starch; maltitol, erythritol Sugar alcohols such as xylitol; proteins such as gelatin, soybean protein and corn protein; amino acids such as glycine, alanine, glutamine and isoleucine; polysaccharides such as cellulose, carboxymethylcellulose, guar gum, chitin, chitosan and gum arabic; Formulate in any dosage form with optional auxiliaries, such as bean oil, rapeseed oil, oils such as medium chain fatty acid triglycerides, preferably before the occurrence of swelling, as soon as possible after the occurrence of swelling Ingested orally.

  Hihatsu and / or hihatsu extract or a formulation thereof may be added to any food or drink, and the hihatsu and / or hihatsu extract may be ingested simultaneously with food or drink.

  Foods and foods to be added with hihatsu and / or hihatsu extract are not particularly limited, but specific examples thereof include chewing gum, candy, tablet confectionery, snack confectionery, granules, powders, soft drinks, tea drinks, alcoholic beverages, etc. There is.

  The preferred intake of baboon for improving the feeling of swelling is about 15 mg to 1,000 mg, more preferably 50 mg to 500 mg in daily food and drink. In the case of a chickpea extract, it is about 15 mg to 1,000 mg, more preferably 50 mg to 500 mg, in terms of the amount of the raw baboon as a raw material.

  The rate of addition of hihatsu and / or hihatsu extract to the food and drink can be appropriately selected in consideration of the preferred intake of the hihatsu and / or hihatsu extract and the amount of food and drink normally consumed.

  Hereinafter, the present invention will be described with reference to examples.

[Example 1]
100 g of dried Hibachi fruit ears were immersed in 1 liter of water and heated under reflux for 2 hours. Thereafter, it was filtered and the residue was again treated with 1 liter of water in the same manner. The extracts obtained by the above two treatments were combined and concentrated under reduced pressure to obtain 12.6 g of a hot water extract.

[Example 2]
100 g of dried ground crumbs of Hibatsu were immersed in 1 liter of ethanol and heated under reflux for 2 hours. Thereafter, the residue was filtered and the residue was again treated with 1 liter of ethanol in the same manner. The extracts obtained by the above two treatments were combined and concentrated under reduced pressure to obtain 9.9 g of an ethanol extract.

[Example 3]
For four subjects in their twenties to thirties (height 154 ± 2 cm) who usually feel swollen, placebo 150 days with dextrin 150 mg of water and hihatsu day with hihatsu hot water extract. An amount of 150 mg in terms of conversion was orally administered at 1 pm with 100 ml of water.

The measurement of swelling was evaluated by measuring the volume from the subject's foot to 15 cm below the upper knee.

  The subjects performed lower limb volume measurement twice a day at 9:00 am and 5:00 pm, and the morning volume and the lower limb volume were compared. At that time, we also asked about swelling. These trials were conducted multiple times per person.

[Table 1] Changes in lower limb volume and swelling body sensitivity (Subject A)
Test zone Volume at 9:00 am Volume at 5:00 pm Volume increase / decrease Volume increase / decrease rate
(Cm ³ ) (cm ³ ) (cm ³ ) (%)
1st placebo 2386.80 2545.92 159.12 106.7
Second placebo 2545.92 2545.92 0.00 100.0
Placebo third time 2426.58 2506.14 79.56 103.3
1st Hihatsu 2466.36 2466.36 0.00 100.0
Second Hibatsu 2585.70 2506.14 -79.56 96.9
Hihatsu 3rd 2466.36 2426.58 -39.78 98.4

  As a result of the interview, the first placebo feels very swollen, the second placebo feels somewhat swollen, the third placebo feels swollen, the first time in the hihatsu feels somewhat swollen, and the second time in the hihatsu has a lot of socks. I felt that there was no swelling, and I didn't feel any swelling in the third Hihatsu.

[Table 2] Changes in lower limb volume and swelling body sensitivity (Subject B)
Test zone Volume at 9:00 am Volume at 5:00 pm Volume increase / decrease Volume increase / decrease rate
(Cm ³ ) (cm ³ ) (cm ³ ) (%)
1st placebo 1949.22 2108.34 159.12 108.2
Second placebo 2148.12 2148.12 0.00 100.0
Placebo third time 2068.56 2068.56 0.00 100.0
1st Hihatsu 2227.68 2148.12 -79.56 96.4
2nd Hihatsu 2267.46 2187.90 -79.56 96.5
Hihatsu 3rd 2267.46 2267.46 0.00 100.0

  As a result of the interview, the placebo feels swelling in the 1st and 2nd place, does not feel so much in the 3rd placebo, does not feel so much in the 1st time of the hihatsu, feels not swollen in the 2nd time of the hihatsu, and not much swelling in the 3rd time of the hihatsu. I didn't feel it.

[Table 3] Changes in lower limb volume and swelling body sensitivity (Subject C)
Test zone Volume at 9:00 am Volume at 5:00 pm Volume increase / decrease Volume increase / decrease rate
(Cm ³ ) (cm ³ ) (cm ³ ) (%)
1st placebo 1869.66 1989.00 119.34 106.4
Second placebo 1949.22 2108.34 159.12 108.2
3rd placebo 1989.00 1949.22 -39.78 98.0
Hihatsu 1st 2028.78 2068.56 42.78 102.0
2nd Hibatsu 2187.90 2108.34 -79.56 96.4
3rd Hihatsu 2108.34 2028.78 -79.56 96.2

  As a result of the interview, I felt swelling in the first and second placebos, less swelling in the third placebo, a little swelling in the first hihatsu, and less swelling in the second and third.

[Table 4] Lower limb volume change and swelling body sensitivity (Subject D)
Test zone Volume at 9:00 am Volume at 5:00 pm Volume increase / decrease Volume increase / decrease rate
(Cm ³ ) (cm ³ ) (cm ³ ) (%)
First placebo 1989.00 1989.00 0.00 100.0
Second placebo 1989.00 2068.56 79.56 104.0
Placebo 3rd 1989.00 2028.78 39.78 102.0
1st Hihatsu 2068.56 2148.12 79.56 103.8
Hihatsu 2nd 2068.56 2028.78 -39.78 98.1
3rd Hihatsu 2108.34 2027.78 -80.56 96.2

  As a result of the interview, the first placebo felt no swelling, the placebo 2 and 3 experienced swelling, the hihatsu first felt swelling, and the second and thirds did not feel swelling.

[Example 4]
For one subject in her 30s who feels swelling everyday (height 153.5 cm), 150 mg of dextrin 150 mg water 100 ml on the placebo day, and 150 mg in terms of hihatsu ethanol extract as raw material hihatsu on hihatsu day. This amount was orally administered at 1 pm with 100 ml of water.

  The measurement of swelling was evaluated by measuring the volume from the subject's foot to 15 cm below the upper knee.

  The subjects performed lower limb volume measurement twice a day at 9:00 am and 5:00 pm, and the morning volume and the lower limb volume were compared. At that time, we also asked about swelling. These trials were conducted multiple times per person.

[Table 5] Lower limb volume change and swelling body sensitivity (Subject E)
Test zone Volume at 9:00 am Volume at 5:00 pm Volume increase / decrease Volume increase / decrease rate
(Cm ³ ) (cm ³ ) (cm ³ ) (%)
1st placebo 1909.44 1989.00 79.56 104.2
Second placebo 1909.44 1989.00 79.56 104.2
1st Hihatsu 1949.22 1949.22 0.00 100.0
2nd Hihatsu 1949.22 1868.66 -79.56 98.1

  As a result of the interview, I felt swelling in the first and second placebos, did not feel swelling in the first one, and did not feel swelling in the second one.

[Example 5]
Gum base 25g
50g sugar
Fructose 15g
Minamata 9g
Lemon flavor 0.5g
Hihatsu hot water extract 0.5g
The said raw material was processed by the conventional method of chewing gum manufacture, and the chewing gum which has a swelling feeling improvement effect was manufactured.

[Example 6]
50g sugar
Minamata 34g
Citric acid 1g
Hihatsu ethanol extract 0.2g
15g of water
The said raw material was processed by the conventional method of candy manufacture, and the candy which has a swelling feeling improvement effect was manufactured.

[Example 7]
Maltitol 73g
Dextrin 6g
Glycerin fatty acid ester 4g
Hihatsu hot water extract 17g
The above raw materials were mixed and tableted to produce a tablet confection having an effect of improving swelling.

[Example 8]
43g beet oligosaccharide
Erythritol 33g
Citric acid 3g
Glycerin fatty acid ester 1g
Hihatsu ethanol extract 20g
The above raw materials were mixed and granulated to produce granules having an effect of improving swelling.

[Example 9]
Fructose dextrose liquid sugar 12g
Vitamin C 0.5g
Citric acid 0.5g
Lemon flavor 0.1g
Hihatsu hot water extract 0.3g
100g of water
The said raw material was melt | dissolved in water and the drink which has a swelling feeling improvement effect was manufactured.

[Example 10]
4g green tea
Black tea 55g
Oolong tea 5g
Hihatsu ethanol extract 35g
Chamomile 1g
The above raw materials were mixed to produce tea bag tea having an effect of improving swelling.

Claims (4)

To improve the spontaneous swelling of the lower limbs that occurs in daily life due to the increase in lower limb volume resulting from fluid leakage from capillaries and the imbalance of fluid collection by the veins and lymphatic system , which contains hihatsu as the active ingredient A swelling improving agent characterized by. Improves spontaneous swelling of the lower limbs that occurs in everyday life due to increased fluid volume from the blood vessels leaking from the capillaries and the imbalance of fluid collection by the veins and lymphatic system, which uses Hihatsu extract as an active ingredient A swelling improving agent characterized by.   The swelling improvement agent according to any one of claims 1 to 2, which improves the feeling of swelling of the lower limbs caused by standing or sitting for a long time in daily life.   4. The swelling feeling improving agent according to claim 3, which improves the swelling feeling of the lower limb from the toes to 15 cm below the upper knee.