JP4845507B2 - Fluorescence observation system - Google Patents

Description

The present invention, when fluorescence observation by a fluorescence endoscope or the like by administering a fluorescent substance, regarding the fluorescent observation system to maintain good fluorescence state of the test object.

  In recent years, a fluorescent substance having an affinity for a lesion such as cancer is administered into the body of a subject to be examined in advance, and the fluorescence from the fluorescent substance accumulated in the lesion is detected by irradiating excitation light that excites the fluorescent substance. Diagnosis and treatment methods are attracting attention.

  For example, in Japanese Patent Laid-Open No. 10-201707, light generated by a lamp is converted into a wavelength range including excitation light in the infrared region and visible light by a band pass filter, and excited in the infrared region through a light guide fiber of an endoscope. In addition, an endoscope apparatus capable of diagnosing and treating a subject administered with a fluorescent indocyanine green derivative-labeled antibody and displaying a fluorescent image and a normal image by visible light on a monitor is disclosed. Has been.

Japanese translation of PCT publication No. 2000-507129 includes a scaled coding means such as a scaled rotary knob capable of setting a variable desired value, and a microcontroller programmed with a pharmacological model. Discloses a device for controlling intravenous injection that maintains a constant concentration of a drug fluid in blood or the like based on a pharmacological model when performing injection.
JP-A-10-201707 Special Table 2000-507129

  In general, when a fluorescent substance is intravenously administered and observed with a fluorescent endoscope or the like in an endoscope apparatus as disclosed in Patent Document 1 described above, the fluorescent substance has a predetermined time after administration. A peak of fluorescence intensity appears later, and thereafter, the fluorescent substance is metabolized, so that the fluorescence intensity gradually decreases. Since the fluorescence intensity of the fluorescent substance is extremely low, in order to observe a good fluorescence image, it is desirable to do this when the fluorescence intensity is at a peak. There is a problem that it is difficult to perform observation at the best timing in a stable manner.

  Moreover, in the device for controlling intravenous injection as disclosed in Patent Document 2 described above, even when the administration target is the same, the time at which the fluorescence intensity peaks due to the fluorescent substance varies due to the temporal variation in metabolism. Therefore, there is always a problem that it is difficult to stably observe at the best timing.

The present invention has been made in view of the above circumstances, and allows good stable fluorescence observed under fluorescence intensity near the peak, a fluorescence observation system which can shorten observation time and improve the diagnosis of The purpose is to provide.

Fluorescence observation system of the present onset bright aspect determines whether the elapsed time set in advance, and the administration start determining means for determining the start of administration of the fluorescent substance upon elapsed time set Me該予, the A dose setting means for setting at least one of the dose and the administration time of the fluorescent substance based on the dose information of the fluorescent substance set in advance after the start of administration is determined by the administration start determining means, and the dose setting Output means for displaying at least one of displaying the dose on the monitor means and administering the fluorescent substance from the automatic administration means based on the dose of the fluorescent substance set by the means; and detecting biological function information, and the biological information detecting means for sending biological function information to the dose setting means, the dosage control device having the fluorescent view to observe the object to be inspected portion of a living body lumen Characterized by comprising apparatus and, a.

According to the fluorescent observation system according to the invention allows a good stable fluorescence observed under fluorescence intensity near the peak, it is possible to shorten the observation time and the improvement of diagnostic property.

Hereinafter, embodiments of the present invention will be described with reference to the drawings.
1 to 5 show a first embodiment of the present invention. FIG. 1 is an explanatory diagram of the entire system when performing fluorescence observation with an endoscope using a dose control device. FIG. 2 is a dose control device. FIG. 3 is an explanatory diagram of a dose information map of a fluorescent substance, FIG. 4 is a flowchart of a dose control program, and FIG. 5 is an explanatory diagram of fluorescence intensity improvement obtained by dose control.

  In FIG. 1, reference numeral 1 indicates a subject to be examined such as a living body in which fluorescence observation is performed by the fluorescence endoscope system 2, and an indocyanine green derivative labeled antibody is dissolved in the subject 1 from the fluorescent substance administration system 3. A fluorescent substance such as a solution is administered intravenously.

  Here, as described in PCT / WO96 / 23525, the exemplified indocyanine green derivative-labeled antibody has affinity for a lesion such as cancer. Accumulate in the lesion. Moreover, since it has a structure similar to that of indocyanine green (ICG) that has been conventionally used for liver function tests, it is highly safe for living bodies.

  The fluorescence endoscope system 2 includes at least a light source 4 that generates excitation light, an endoscope 5 that guides the excitation light to a living body lumen 1a and observes fluorescence generated from a lesioned part, and is incorporated in the endoscope 5. A camera control unit 7 for driving a color imaging device 6 to convert a fluorescent image of a lesioned part into a video signal, an image processor 8 for processing the video signal to easily recognize a lesioned part and a normal part, and an output of the image processor 8 And a monitor 9 for displaying the image as an image.

  The light source 4 incorporates a laser 10 such as an excimer that emits light in the blue or ultraviolet region, He—Cd, or argon.

  The endoscope 5 includes a light guide 11 that guides laser light emitted from a laser 10 to a living body lumen 1a, a concave lens 12 that diffuses and illuminates the laser light, and an objective that projects a fluorescent image of a lesion onto a color imaging device 6. The lens 13 and the optical filter 14 that transmits a specific wavelength in the fluorescent image from the objective lens 13 are mainly configured. Here, the optical filter 14 has a predetermined transmission characteristic.

  Although not shown, the light source 4 is provided with a xenon lamp that generates white light and a switching unit that switches the light of the laser and the xenon lamp and supplies the light to the light guide 11. The endoscope 5 has a built-in image sensor (not shown) that captures an image of white light.

  Therefore, in the fluorescence endoscope system 2 configured as described above, the laser light emitted from the laser 10 is incident on the light guide 11 built in the endoscope 5 and guided to the living body lumen 1a. The laser light is diffused by the concave lens 12 and applied to the living body lumen 1a. Fluorescence is emitted from the lesioned part and the surrounding normal part by this laser light, and this is projected onto the color imaging device 6 through the objective lens 13 and the optical filter 14, and the signal is output by the camera control unit 7 and the image processor 8. Process and display on the monitor 9 for fluorescence observation.

  The fluorescence endoscope system 2 is not limited to the one in the first embodiment, and may have another configuration.

  On the other hand, the fluorescent substance administration system 3 is fixedly installed in the middle of the support column 17 of the drip stand 16 and the drip container 19 suspended by the suspension member 18 on the upper portion of the support column 17 of the drip stand 16. An automatic administration device 20 as an automatic administration means for administering the fluorescent substance to the subject 1 to be examined, a dose control device 21 for controlling administration to the subject 1 from the automatic administration device 20, and a living body of the subject 1 to be examined It mainly includes a biological information detection unit 100 that detects functional information.

  The infusion container 19 is filled with a fluorescent substance such as a solution in which the above-mentioned indocyanine green derivative-labeled antibody is dissolved, and is connected to the automatic administration device 20 via an infusion tube 22. Supply into the syringe 23.

  The automatic administration device 20 is, for example, an automatic infusion device, and drops the fluorescent substance from the infusion container 19 in the syringe 23. Then, the fluorescent substance is administered from the syringe 23 via the infusion tube 25 to the vein of the subject 1 to be examined. At this time, the fluorescent substance with respect to the subject 1 to be examined is variably adjusted by the control signal from the dose control device 21 or the operation of the operator by the pressing force of the pressing member 24 provided at the end of the syringe 23. Intravenous administration at the target flow rate can be performed automatically or manually.

  The biological information detection unit 100 is a biological information detection unit, is disposed on the skin of the subject 1 to be examined, and is electrically connected to the dose control device 21. In addition, the biological information detection unit 100 detects biological function information of the subject 1 to be examined and transmits the biological function information to the dose control device 21. Here, the above-mentioned biological function information is information related to metabolic information such as heart rate, oxygen saturation, blood pressure, and the like, which can be detected through the skin of the subject 1 to be examined. When measuring biological function information, a known measuring instrument can be used as the biological information detection unit 100 as appropriate. For example, a measuring instrument such as a pulse oximeter is used for measuring oxygen saturation.

  The dose control device 21 receives an automatic administration start time, an administration end condition, and the like by an operator, biological function information is input by the biological information detection unit 100, and is administered by a dosage information map according to a dosage control program to be described later. Set the dose according to the time. When the administration time is reached, the dosage control device 21 outputs an output signal corresponding to the dosage to the automatic administration device 20 (when automatic administration is performed by the automatic administration device 20), and the dosage and administration. The time or the like is displayed on the monitor unit 21g as a monitor means.

  Further, during the automatic administration by the automatic administration device 20, the dosage control device 21 determines the dosage or administration timing of the fluorescent substance when the biological function information of the test subject 1 detected by the biological information detection unit 100 fluctuates. to correct.

  In order to realize such a function, for example, as shown in FIG. 2, the dose control device 21 includes a timekeeping unit 21a, a dose data storage unit 21b, a biological information reference value storage unit 21c, a dose data correction unit 21d, The administration end condition determination unit 21e, the main control unit 21f, and the monitor unit 21g are mainly configured.

  The timer unit 21a is a so-called timer, and the main controller 21f reads the elapsed time as necessary.

  The dose data storage unit 21b stores necessary doses obtained in advance through experiments, theoretical calculations, and the like as a map (dose information map) according to time. For example, as shown in FIG. 3A, this dose information map is continuously set so as to decrease linearly with the elapsed time after the administration start time T1. Note that the dose information map may have a non-linear characteristic as shown in FIG. 3 (b), and this characteristic is obtained as appropriate by experiments and theoretical calculations in advance. . The dose information map stored in the dose data storage unit 21b is read as necessary by the dose data correction unit 21d. The dose information map is not limited to the above-described form. For example, the dose information map is not continuous so as to decrease according to the elapsed time, but is continuously administered at a constant dose, or increased or decreased as time elapses. It may be continuous. Moreover, it does not decrease according to the elapsed time as shown in FIG. 3A, but increases linearly according to the elapsed time after the administration start time T1, for example, as shown in FIG. 3C. It may be set continuously. Similarly, FIG. 3B does not decrease according to the elapsed time. For example, as shown in FIG. 3D, after the administration start time T1, it has a non-linear characteristic, and according to the elapsed time. You may set continuously so that it may increase.

  In the biological information reference value storage unit 21c, general biological function information such as heart rate is stored as a biological function information reference value for each body weight, age, sex, and the like. The data correction unit 21d reads the data as necessary.

  When the automatic administration device 20 is functioning, the dose data correction unit 21d always receives the biological function information of the subject 1 to be examined from the biological information detection unit 100. Then, the dose data correction unit 21d compares the input biological function information with the biological function information reference value stored in the biological information reference value storage unit 21c, and determines whether the dosage and the administration time are appropriate. To do. If it is determined that it is not appropriate, the dose data correction unit 21d corrects at least one of the dose and the administration time. For example, correction such as increasing the administration time when the heart rate becomes faster and decreasing the administration time when the heart rate becomes slower is made. The dose and administration time correction signals are transmitted from the dose data correction unit 21d to the automatic administration device 20. The automatic administration device 20 adjusts the administration of the fluorescent substance based on the correction signal. A series of these processes is performed a predetermined number of times within the time when the fluorescent substance is administered.

  The administration end condition determination unit 21e determines whether or not the administration end condition is input by the operator and satisfies the administration end condition, and outputs a signal to the main control unit 21f when satisfied. Here, the administration end condition is, for example, the total time during which the fluorescent substance is automatically administered, the total dose of the fluorescent substance, forced OFF of automatic administration (switch operation by the operator), etc., and any one of these conditions When even one condition is satisfied, a signal indicating completion of automatic administration is output to the main control unit 21f.

  The main control unit 21f receives an automatic administration start time T1 by the operator. Then, the main control unit 21f determines that the automatic administration start time T1 has been reached, and thereafter sets the fluorescent substance dose according to the time according to the dose information map of the dose data storage unit 21b. When the automatic administration device 20 is functioning (when the automatic administration device 20 is ON), the main control unit 21f outputs a signal corresponding to the dosage to the automatic administration device 20, and the dosage to the monitor unit 21g. And display the administration time. On the other hand, when the automatic administration device 20 is not functioning (when the automatic administration device 20 is OFF), the monitor unit 21g displays that the automatic administration device 20 is OFF, and displays the dosage and administration time. I do. Further, when the administration end signal is input from the administration end condition determining unit 21e, the automatic administration is terminated.

  As described above, the dose control device 21 is configured to include the functions of the administration start determination unit, the dose setting unit, and the output unit.

  Next, the dose control program executed by the dose control device 21 will be described with reference to the flowchart of FIG. First, in step (hereinafter abbreviated as “S”) 101, the automatic administration start time T1 input by the operator is read, and it proceeds to S102 to determine whether or not the automatic administration start time T1 has been reached.

  If it is determined in S102 that the automatic administration start time T1 has been reached, the process proceeds to S103, and the dose is set with reference to a map (dose information map) set in advance based on the time from the start of automatic administration. Do.

  Then, it progresses to S104 and it is determined whether the automatic administration apparatus 20 is ON. If the result of this determination is ON, the process proceeds to S105, where the biological information detection unit 100 detects the biological function information of the subject 1 to be examined and transmits the biological function information to the dose data correction unit 21d.

  Then, the process proceeds to S106, and the dose data correction unit 21d determines whether or not the dose of the fluorescent substance is appropriate based on the biological function information. As a result, if appropriate, the process proceeds to S107, a signal corresponding to the dose set in S103 is output to the automatic administration apparatus 20, and the process proceeds to S110. On the other hand, if it is not appropriate, the process proceeds to S108, where the dose data correction unit 21d corrects at least one of the dose and the administration time, and outputs a signal corresponding to the corrected dose / administration time, and S110. Proceed to

  On the other hand, in the above-described S104, if the automatic administration device 20 is OFF, the process proceeds to S109, displays that the automatic administration device 20 is OFF on the monitor unit 21g, and proceeds to S110.

  When the process proceeds from S107, S108, or S109 to S110, the dose and the administration time are displayed on the monitor unit 21g. When the dose and the administration time are displayed on the monitor unit 21g when the automatic administration device 20 is OFF, the operator administers the fluorescent substance himself.

  And it progresses to S111, it is determined whether the administration end condition is satisfied, and when the administration end condition is not satisfied, the processing from S103 is repeated, and when the administration end condition is satisfied, Proceeding to S112, each data (time measured, etc.) is cleared, proceeding to S113, displaying the end of administration on the monitor unit 21g, and exiting the program.

  That is, conventionally, as shown by the broken line in FIG. 5, a peak of the fluorescence intensity appears after a predetermined time Tp from the initial administration, and thereafter, the fluorescent substance is metabolized, and the fluorescence intensity gradually decreases. However, when the fluorescent substance is administered using the dose control device 21 according to the first embodiment, as shown by the solid line in FIG. 5, the fluorescence intensity close to the peak for a while after reaching the peak. Can be maintained.

  For this reason, even if the fluorescence intensity at a strict peak cannot be obtained due to individual differences of the subject 1 to be inspected, it is possible to perform a good fluorescence observation with a fluorescence intensity close to the peak flexibly.

  In addition, since the situation where the fluorescence intensity is close to the peak can be maintained for a long time, it is not necessary to strictly grasp the time when the fluorescence intensity reaches the peak, so that the observation can be afforded and stable observation can be performed. .

  In addition, it is not necessary to divide the observation into a plurality of times aiming at the peak of the fluorescence intensity, and observation with very little load is possible for the observer and the subject 1 to be examined.

  When the automatic administration device 20 is functioning, the dose data correction unit 21d can repeatedly correct the dose and the administration time of the fluorescent substance based on the biological function information of the subject 1 to be examined. . As a result, an optimal dose of the fluorescent substance can be administered from the automatic administration device 20 to the subject 1 according to the temporal variation of the metabolism of the subject 1 to be examined.

  Next, FIG. 6 to FIG. 8 show a second embodiment of the present invention, FIG. 6 is a functional block diagram of the dose control device, FIG. 7 is an explanatory diagram of the dose information map correction of the fluorescent substance, and FIG. It is a flowchart of a dosage control program. Note that the second embodiment is different from the first embodiment in that the dose information map in the dose control device can be corrected according to the metabolic information, and other constituent actions are the same as in the first embodiment. Therefore, the same components are denoted by the same reference numerals and description thereof is omitted.

  That is, as shown in FIG. 6, in the dose control device 31, an automatic administration start time, administration end condition, metabolic information (described later) and the like are input by the operator, and biological function information is input by the biological information detection unit 100. In accordance with a dose control program to be described later, a dose or the like corresponding to the administration time is set by a dose information map that is set by correction with metabolic information. When the administration time is reached, the dosage control device 31 outputs an output signal corresponding to the dosage to the automatic administration device 20 (when automatic administration is performed by the automatic administration device 20), and the dosage and administration. The time or the like is displayed on the monitor unit 21g as a monitor means.

  Further, during the automatic administration by the automatic administration device 20, the dose control device 31 determines the dose or administration timing of the fluorescent substance when the biological function information of the test subject 1 detected by the biological information detection unit 100 fluctuates. to correct.

  Here, the above-mentioned metabolic information is obtained in advance by blood concentration test or the like for the subject 1 to be examined. For example, γ-GTP (γ-glutamyl transpeptidase), GOT (glutamic acid) in blood It is obtained from the enzyme concentration observed when the onset of an enzyme such as cathepsin B, cathepsin L, uPA (urokinase-type plasminogen activator) such as oxaloacetate transaminase).

  And in order to implement | achieve the function of the above-mentioned dose control, as shown in FIG. 6, for example, the dose control apparatus 31 is the time measuring part 21a, the administration end condition judgment part 21e, the monitor part 21g, and dosage data storage. It is mainly configured by including a unit 31b, a biological information reference value storage unit 31c, a dose data correction unit 31d, and a main control unit 31f.

  The dose data storage unit 31b is a map (dose information) that shows the required dose corresponding to the above-mentioned metabolic information reference value and biological function information reference value obtained in advance by experiments or theoretical calculations. Map). For example, as shown by the solid line in FIG. 7, this dose information map is continuously set so as to decrease linearly according to the elapsed time after the administration start time T1. The dose information map stored in the dose data storage unit 31b is read as necessary by the dose data correction unit 31d.

  The biological information reference value storage unit 31c stores general metabolic information of the above-described enzyme and biological function information such as heart rate for each body weight, age, sex, etc., as a metabolic information reference value and a biological function information reference value, respectively. The metabolic information reference value and the biological function information reference value are read as necessary by the dose data correction unit 31d.

  The dose data correction unit 31d receives the metabolic information of the subject 1 to be examined by the operator, the biological function information from the biological information detection unit 100, and the metabolic information reference value and the biological information reference value storage unit 31c. A biological function information reference value is input, and a dose information map is input from the dose data storage unit 31b.

  Then, the dose data correction unit 31d compares the metabolic information of the subject 1 to be examined with the metabolic information reference value to determine whether it is large or small. For example, the metabolic information of the subject 1 to be examined is the metabolic information reference value. If it is 10% larger, the administration time of the fluorescent substance is corrected by 10% longer. Conversely, when the metabolic information of the subject 1 to be examined is 10% smaller than the metabolic information reference value, the administration time of the fluorescent substance is corrected so as to be shortened by 10%. This correction example is indicated by a broken line in FIG. The correction example shown here is merely an example, and may be another correction example (for example, the ratio of the time for increasing correction and the time for decreasing correction is different). Instead of decreasing the dose with the passage of time as shown in FIG. 7, the dose correction data unit 31d may correct the dose so as to increase the rate and increase or decrease the rate. Further, by combining the above correction methods, the dose correction data unit 31d may correct the dose so as to increase / decrease the dose, change its end time, or increase / decrease the rate of increase.

  In addition, when the automatic administration device 20 is functioning, the dose data correction unit 31d always receives the biological function information of the subject 1 to be examined from the biological information detection unit 100. Then, the dose data correction unit 31d compares the input biological function information with the biological function information reference value stored in the biological information reference value storage unit 31c, and determines whether the dosage and the administration time are appropriate. To do. When it is determined that it is not appropriate, the dose data correction unit 31d corrects at least one of the dose and the administration time. For example, correction such as increasing the administration time when the heart rate becomes faster and decreasing the administration time when the heart rate becomes slower is made. The dose and administration time correction signals are transmitted from the dose data correction unit 31d to the automatic administration device 20. The automatic administration device 20 adjusts the administration of the fluorescent substance based on the correction signal. A series of these processes is performed a predetermined number of times within the time when the fluorescent substance is administered.

  The main control unit 31f receives an automatic administration start time T1 from the operator. Then, the main control unit 31f determines that the automatic administration start time T1 has been reached, and thereafter sets the dose of the fluorescent substance according to the time according to the dose information map corrected by the dose data correction unit 31d. . When the automatic administration device 20 is functioning (when the automatic administration device 20 is ON), the main control unit 31f outputs a signal corresponding to the dosage to the automatic administration device 20, and the dosage to the monitor unit 21g. And display the administration time. On the other hand, when the automatic administration device 20 is not functioning (when the automatic administration device 20 is OFF), the monitor unit 21g displays that the automatic administration device 20 is OFF, and displays the dosage and administration time. I do. Further, when the administration end signal is input from the administration end condition determining unit 21e, the automatic administration is terminated.

  As described above, the dose control device 31 is configured to include the functions of the administration start determination unit, the dose setting unit, and the output unit.

  Next, a dose control program executed by the dose control device 31 will be described with reference to the flowchart of FIG. First, in S201, the automatic administration start time T1 input by the operator is read, and it proceeds to S202 to determine whether or not the automatic administration start time T1 has been reached.

  If it is determined in S202 that the automatic administration start time T1 has been reached, the process proceeds to S203, and metabolic information is read.

  Next, in S204, the metabolic information reference value is read from the database (dose data storage unit 31b).

  In step S205, the metabolic information read in step S203 is compared with the metabolic information reference value read in step S204 to determine a correction value for the administration time, that is, how long the correction is made or how much is corrected. Calculate.

  Thereafter, the process proceeds to S206, and a map (dose information map) set in advance is corrected based on the correction value calculated in S205.

  Next, the process proceeds to S207, and the dose is set with reference to the dose information map corrected in S206 based on the time from the start of automatic administration.

  Then, it progresses to S208 and it is determined whether the automatic administration apparatus 20 is ON. As a result of this determination, if it is ON, the process proceeds to S209, where the biological information detection unit 100 detects the biological function information of the subject 1 to be examined, and transmits the biological function information to the dose data correction unit 31d.

  In S210, the dose data correction unit 31d determines whether or not the dose of the fluorescent substance is appropriate based on the biological function information. As a result, if appropriate, the process proceeds to S211 and a signal corresponding to the dose set in S207 is output to the automatic administration apparatus 20, and the process proceeds to S214. On the other hand, if it is not appropriate, the process proceeds to S212, in which the dose data correction unit 31d corrects at least one of the dose and the administration time, and outputs a signal corresponding to the corrected dose / administration time to output S214. Proceed to

  On the other hand, if the automatic administration device 20 is OFF in the above-described S208, the process proceeds to S213 to display on the monitor unit 21g that the automatic administration device 20 is OFF, and the process proceeds to S214.

  When the process proceeds from S211, S212, or S213 to S214, the dose and the administration time are displayed on the monitor unit 21g. When the dose and the administration time are displayed on the monitor unit 21g when the automatic administration device 20 is OFF, the operator administers the fluorescent substance himself.

  Then, the process proceeds to S215, where it is determined whether or not the administration end condition is satisfied. When the administration end condition is not satisfied, the processing from S207 is repeated, and when the administration end condition is satisfied, Proceeding to S216, each data (time measured, etc.) is cleared, proceeding to S217, displaying the end of administration on the monitor unit 21g, and exiting the program.

  As described above, according to the second embodiment, the effect described in the first embodiment can be obtained, and the dose information map is corrected and set by the metabolic information. It is possible to keep the peak of the fluorescence intensity more stably and accurately for a long time without being affected by individual differences and metabolic time fluctuations, and fluorescence observation can be easily performed.

  Next, FIGS. 9 to 11 show a third embodiment of the present invention, FIG. 9 is a functional block diagram of a dose control device, FIG. 10 is an explanatory diagram of a dose information table of a fluorescent substance, and FIG. It is a flowchart of a quantity control program. The third embodiment is different from the first embodiment in that the administration of the fluorescent substance in the dose control device is performed at preset time intervals, and the other constituent actions are the same as the first embodiment. Therefore, the same components are denoted by the same reference numerals, and description thereof is omitted.

  That is, in FIG. 9, reference numeral 41 denotes a dose control device according to the third embodiment. This dose control device 41 is input with an automatic administration start time, an administration end condition, etc. by an operator, and will be described later. In accordance with the dose control program, the dose is set for each time interval (number of times of administration) set in advance by the dose information table, and at the time of administration, an output signal corresponding to the dose is output to the automatic administration device 20 ( When automatic administration is performed by the automatic administration device 20, the dose, administration time, and the like are displayed on the monitor unit 21g as a monitor means.

  And in order to implement | achieve the function of the above-mentioned dosage control, the dosage control apparatus 41, as shown in FIG. 9, for example, the time measuring part 21a, the administration end condition judgment part 21e, the monitor part 21g, and the dosage data storage It is mainly configured with a part 41a and a main control part 41b.

  In the dose data storage unit 41a, necessary doses obtained in advance by experiments or theoretical calculations are stored as a table (dose information table) corresponding to each time interval (every number of administrations). It is. For example, as shown in FIG. 10, the dose based on this dose information table is set so as to gradually decrease every time after the administration start time T1. The dose information table stored in the dose data storage unit 41a is read as necessary by the main control unit 41b.

  The main control unit 41b receives an automatic administration start time T1 from the operator. Then, the main control unit 41b determines that the automatic administration start time T1 has been reached, and thereafter, every set time interval (every number of administrations) according to the dose information table stored in the dose data storage unit 41a. Set the dose of the fluorescent substance. When the automatic administration device 20 is functioning (when the automatic administration device 20 is ON), the main control unit 41b outputs a signal corresponding to the dosage to the automatic administration device 20, and the dosage to the monitor unit 21g. And display the administration time. On the other hand, when the automatic administration device 20 is not functioning (when the automatic administration device 20 is OFF), the monitor unit 21g displays a display indicating that the automatic administration device 20 is OFF, and the dosage and administration time. Let Further, when the administration end signal is input from the administration end condition determining unit 21e, the automatic administration is terminated.

  Thus, the dose control device 41 is configured to include the functions of the administration start determination unit, the dose setting unit, and the output unit. As shown in FIG. 10, instead of decreasing the dose every time interval, a dose information table that increases or decreases the dose is stored in the dose data storage unit 41a, and the main control unit You may make it read by 41b.

  Next, a dose control program executed by the dose control device 41 will be described with reference to the flowchart of FIG. First, in S301, the automatic administration start time T1 input by the operator is read, and it proceeds to S302 and determines whether or not the automatic administration start time T1 has been reached.

  If it is determined in S302 that the automatic administration start time T1 has been reached, the process proceeds to S303, and a dose is determined with reference to a preset table (dose information table) based on the value of the automatic administration frequency counter CT. Set. The automatic administration number counter CT is a counter for counting the number of administrations, and the initial value is set to zero.

  Next, the process proceeds to S304, where it is determined whether or not the automatic administration number counter CT is 0 (initial). If the automatic administration number counter CT is 0 (initial), the process proceeds to S306 to administer the fluorescent substance as it is. .

  If the automatic administration number counter CT is not 0 (first time), the process proceeds to S305, where it is determined whether the set time Tc has elapsed since the previous administration, and when it has elapsed, the process proceeds to S306 to administer the fluorescent substance. Proceed with

  Then, when the process proceeds to S306 to administer the fluorescent substance, it is determined whether or not the automatic administration apparatus 20 is ON. If it is ON, the process proceeds to S307 and the dosage set in S303 for the automatic administration apparatus 20 is determined. Output a signal according to. Then, the process proceeds to S308, the automatic administration number counter CT is incremented (CT = CT + 1) for the next administration, and the process proceeds to S310.

  On the contrary, when the automatic administration device 20 is OFF, the process proceeds to S309 to display on the monitor unit 21g that the automatic administration device 20 is OFF, and then the process proceeds to S310.

  When the process proceeds from S308 or S309 to S310, the dose and the administration time are displayed on the monitor unit 21g. When the dose and the administration time are displayed on the monitor unit 21g when the automatic administration device 20 is OFF, the operator administers the fluorescent substance himself.

  And it progresses to S311 and it is determined whether the administration end condition is satisfied, and when the administration end condition is not satisfied, the processing from S303 is repeated, and when the administration end condition is satisfied, Proceeding to S312, each data (time measured, automatic administration number counter CT, etc.) is cleared, proceeding to S313, displaying the end of administration on the monitor unit 21g and exiting the program.

  Thus, even when the fluorescent substance is administered at set time intervals as in the third embodiment, the same effect as in the first embodiment can be obtained.

  In the first to third embodiments described above, a fluorescent drug (fluorescent agent, fluorescent substance) is administered intravenously, but the present invention is not limited to this, and the subject to be examined is orally or sprayed in the body. 1 may be administered. In the case of oral administration, the monitor unit 21g displays the administration timing for oral administration of the fluorescent agent. The subject 1 to be inspected takes a predetermined amount of a fluorescent drug in accordance with the displayed administration timing. Further, in the case of spraying in the body, the infusion tube 25 is inserted through a treatment instrument insertion channel (not shown) provided in the endoscope 5 by the fluorescence endoscope system 2 which is an in-vivo medical device. According to this configuration, the fluorescent agent dripped from the infusion container 19 of the automatic administration device 20 is distributed to the living body lumen 1 a of the subject 1 to be examined from the vicinity of the distal end of the endoscope 5 through the infusion tube 25.

  In each of the above-described embodiments, a fluorescent substance such as a solution in which an indocyanine green derivative-labeled antibody is dissolved has been described as an example. However, it goes without saying that the present invention can be applied to other fluorescent substances.

Explanatory drawing of the whole system at the time of performing fluorescence observation by an endoscope using the dosage control apparatus by 1st Embodiment of this invention Same as above, functional block diagram of dose control device Same as above, explanatory diagram of dose information map of fluorescent substance Same as above, flowchart of dose control program Same as above, explanatory diagram of fluorescence intensity improvement obtained by dose control Functional block diagram of the dose control device according to the second embodiment of the present invention Same as above, explanatory diagram of dose information map correction of fluorescent substance Same as above, flowchart of dose control program Functional block diagram of a dose control device according to a third embodiment of the present invention Same as above, explanatory diagram of dose information table of fluorescent substance Same as above, flowchart of dose control program

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Test object 2 Fluorescence endoscope system 3 Fluorescent substance administration system 5 Endoscope 19 Drip container 20 Automatic administration apparatus (automatic administration means)
21, 31, 41 Dose control device (administration start determination means, dose setting means, output means)
21a Timekeeping unit 21b, 31b, 41a Dose data storage unit 21c, 31c Biological information reference value storage unit 21d, 31d Dose data correction unit 21e Administration end condition determination unit 21f, 31f, 41b Main control unit 21g Monitor unit (monitoring means) )
100 Biological information detection unit (biological information detection means)

Claims (8)

Determining whether a preset time has elapsed, and administration start determining means for determining the start of administration of the fluorescent substance when the preset time has elapsed;
A dose setting means for setting at least one of the dose and the administration time of the fluorescent substance based on the dose information of the fluorescent substance set in advance, after determining the administration start by the administration start determination means;
Based on the dose of the fluorescent substance set by the dose setting means, an output means for displaying at least one of displaying the dose on the monitor means and causing the fluorescent substance to be administered from the automatic administration means,
Biological information detecting means for detecting biological function information to be examined and sending the biological function information to the dose setting means;
A dose control device comprising:
A fluorescence observation apparatus for observing a region to be examined in a living body lumen;
A fluorescence observation system comprising:   2. The fluorescence observation system according to claim 1, wherein the dose information is set continuously at least once or more according to an elapsed time after the administration start determination means determines that the administration is started.   2. The fluorescence observation system according to claim 1, wherein the preset dose information of the fluorescent substance is continuously set so as to decrease in accordance with an elapsed time after the start of the administration.   The dose information of the fluorescent substance set in advance is administered at a preset time interval after the start of the administration, and is gradually set to a smaller dose. Fluorescence observation system.   The fluorescence observation system according to any one of claims 1 to 4, wherein the preset dose information of the fluorescent substance can be corrected according to metabolic information acquired in advance. .   6. The fluorescence observation system according to claim 1, wherein the automatic administration unit administers the fluorescent substance intravenously.   The fluorescence observation system according to any one of claims 1 to 6, wherein the monitor means displays an administration timing for administering the fluorescent substance. In the fluorescence observation system according to any one of claims 1 to 7,
The fluorescence observation device is characterized in that the fluorescent material is dispersed in a living body lumen.

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