JP4827384B2 - Purifying agent for inhibiting the formation of lipid peroxides in the body - Google Patents
Purifying agent for inhibiting the formation of lipid peroxides in the body Download PDFInfo
- Publication number
- JP4827384B2 JP4827384B2 JP2004087894A JP2004087894A JP4827384B2 JP 4827384 B2 JP4827384 B2 JP 4827384B2 JP 2004087894 A JP2004087894 A JP 2004087894A JP 2004087894 A JP2004087894 A JP 2004087894A JP 4827384 B2 JP4827384 B2 JP 4827384B2
- Authority
- JP
- Japan
- Prior art keywords
- fullerene
- ascorbic acid
- porous
- lipid peroxide
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 lipid peroxides Chemical class 0.000 title claims description 44
- 239000012629 purifying agent Substances 0.000 title claims description 18
- 230000002401 inhibitory effect Effects 0.000 title claims description 5
- 230000015572 biosynthetic process Effects 0.000 title claims description 3
- XMWRBQBLMFGWIX-UHFFFAOYSA-N C60 fullerene Chemical compound C12=C3C(C4=C56)=C7C8=C5C5=C9C%10=C6C6=C4C1=C1C4=C6C6=C%10C%10=C9C9=C%11C5=C8C5=C8C7=C3C3=C7C2=C1C1=C2C4=C6C4=C%10C6=C9C9=C%11C5=C5C8=C3C3=C7C1=C1C2=C4C6=C2C9=C5C3=C12 XMWRBQBLMFGWIX-UHFFFAOYSA-N 0.000 claims description 36
- 229910003472 fullerene Inorganic materials 0.000 claims description 33
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 32
- 239000011148 porous material Substances 0.000 claims description 20
- 238000000746 purification Methods 0.000 claims description 17
- 238000004519 manufacturing process Methods 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 12
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 claims description 12
- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 12
- 239000001267 polyvinylpyrrolidone Substances 0.000 claims description 12
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 12
- 235000019353 potassium silicate Nutrition 0.000 claims description 9
- NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims description 9
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 7
- 229910021536 Zeolite Inorganic materials 0.000 claims description 4
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 claims description 4
- 239000000123 paper Substances 0.000 claims description 4
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- 230000001413 cellular effect Effects 0.000 claims 1
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- 230000002292 Radical scavenging effect Effects 0.000 description 15
- 238000001179 sorption measurement Methods 0.000 description 11
- 238000000034 method Methods 0.000 description 9
- 150000002632 lipids Chemical class 0.000 description 8
- 210000004072 lung Anatomy 0.000 description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
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- 239000002516 radical scavenger Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 5
- 239000012752 auxiliary agent Substances 0.000 description 5
- 150000002978 peroxides Chemical class 0.000 description 5
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- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 4
- OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 4
- 239000003463 adsorbent Substances 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 4
- 239000012459 cleaning agent Substances 0.000 description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
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- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 4
- RWSOTUBLDIXVET-UHFFFAOYSA-N Dihydrogen sulfide Chemical compound S RWSOTUBLDIXVET-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
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- 239000007789 gas Substances 0.000 description 3
- 235000011187 glycerol Nutrition 0.000 description 3
- 229910000037 hydrogen sulfide Inorganic materials 0.000 description 3
- 238000011068 loading method Methods 0.000 description 3
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- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 2
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- ATLMFJTZZPOKLC-UHFFFAOYSA-N C70 fullerene Chemical compound C12=C(C3=C4C5=C67)C8=C9C%10=C%11C%12=C%13C(C%14=C%15C%16=%17)=C%18C%19=C%20C%21=C%22C%23=C%24C%21=C%21C(C=%25%26)=C%20C%18=C%12C%26=C%10C8=C4C=%25C%21=C5C%24=C6C(C4=C56)=C%23C5=C5C%22=C%19C%14=C5C=%17C6=C5C6=C4C7=C3C1=C6C1=C5C%16=C3C%15=C%13C%11=C4C9=C2C1=C34 ATLMFJTZZPOKLC-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 2
- 235000001815 DL-alpha-tocopherol Nutrition 0.000 description 2
- 239000011627 DL-alpha-tocopherol Substances 0.000 description 2
- 235000001809 DL-alpha-tocopherylacetate Nutrition 0.000 description 2
- 239000011626 DL-alpha-tocopherylacetate Substances 0.000 description 2
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 229920002125 Sokalan® Polymers 0.000 description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-N Sulfurous acid Chemical compound OS(O)=O LSNNMFCWUKXFEE-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000003213 activating effect Effects 0.000 description 2
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 2
- 229910021529 ammonia Inorganic materials 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 235000013793 astaxanthin Nutrition 0.000 description 2
- 239000001168 astaxanthin Substances 0.000 description 2
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 2
- 229940022405 astaxanthin Drugs 0.000 description 2
- 230000036952 cancer formation Effects 0.000 description 2
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- 231100000504 carcinogenesis Toxicity 0.000 description 2
- 231100000315 carcinogenic Toxicity 0.000 description 2
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 2
- 235000005487 catechin Nutrition 0.000 description 2
- 210000000170 cell membrane Anatomy 0.000 description 2
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- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
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- 229960002715 nicotine Drugs 0.000 description 2
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- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 2
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- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
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- 159000000003 magnesium salts Chemical class 0.000 description 1
- NGPNWUWGVIIIDG-LEJBHHMKSA-L magnesium;[(2r)-2-[(1s)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2h-furan-3-yl] phosphate Chemical compound [Mg+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1OP([O-])([O-])=O NGPNWUWGVIIIDG-LEJBHHMKSA-L 0.000 description 1
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- 150000003254 radicals Chemical class 0.000 description 1
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- NPCOQXAVBJJZBQ-UHFFFAOYSA-N reduced coenzyme Q9 Natural products COC1=C(O)C(C)=C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)C(O)=C1OC NPCOQXAVBJJZBQ-UHFFFAOYSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000029058 respiratory gaseous exchange Effects 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
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- 125000001424 substituent group Chemical group 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
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- 229950009883 tocopheryl nicotinate Drugs 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
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- 235000019163 vitamin B12 Nutrition 0.000 description 1
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- 229940046009 vitamin E Drugs 0.000 description 1
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- 239000011709 vitamin E Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000002023 wood Substances 0.000 description 1
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
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- JHSRBKFWAUSZQN-LEJBHHMKSA-L zinc;[(2r)-2-[(1s)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2h-furan-4-yl] phosphate Chemical compound [Zn+2].OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1O JHSRBKFWAUSZQN-LEJBHHMKSA-L 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
Landscapes
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Physics & Mathematics (AREA)
- Composite Materials (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Materials Engineering (AREA)
- Crystallography & Structural Chemistry (AREA)
- Disinfection, Sterilisation Or Deodorisation Of Air (AREA)
- Filtering Materials (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Description
この出願の発明は生体の過酸化脂質の生成抑制用の浄化剤に関するものである。 The invention of this application relates to a purifying agent for suppressing the production of lipid peroxide in a living body .
近年、化石燃料の大量消費、産業廃棄物や家庭ごみの大量廃棄などによる生活環境の近代化に伴い、生活空間に存在する微量な硫化水素、亜硫酸ガス、ニコチン、タール、活性酸素、ラジカル、ダイオキシン、花粉や粉塵等の有害物質に対する関心が高まっている。生活空間から、これらの微量の有害物質を除去して快適な生活環境を維持するために、流動体及び固体及び固体物質清浄器などの流動体及び固体及び固体物質の浄化装置や吸着剤、脱臭剤などが要求され、一般の家庭生活にも様々な有害物質吸着剤や分解除去剤等の浄化剤が使用されるようになってきている。これらの有害物質吸着剤、脱臭剤などは日常生活で使用されるものであるから次のような条件を満たすものであることが要求される。
（１）日常の生清空間に存在する微量な硫化水素、亜硫酸ガス、ニコチン、タール、活性酸素、ラジカル等の各種有害物質に対して優れた吸着性や解毒性能を有するものであること。
（２）安全性が高いものであること。
（３）取扱が容易なものであること。
In recent years, with the modernization of the living environment by mass consumption of fossil fuels, mass disposal of industrial waste and household waste, trace amounts of hydrogen sulfide, sulfurous acid gas, nicotine, tar, active oxygen, radicals, dioxins present in living spaces There is a growing interest in harmful substances such as pollen and dust. In order to remove these trace amounts of harmful substances from living space and maintain a comfortable living environment, fluid and solid and solid substance purifiers and adsorbents, deodorizers such as fluid and solid and solid substance purifiers Therefore, various cleaning agents such as adsorbents for toxic substances and decomposition / removal agents have been used in general household life. Since these harmful substance adsorbents and deodorizers are used in daily life, it is required to satisfy the following conditions.
(1) It has excellent adsorptivity and detoxification performance for various harmful substances such as minute amounts of hydrogen sulfide, sulfurous acid gas, nicotine, tar, active oxygen, radicals, etc. existing in daily living space.
(2) High safety.
(3) It must be easy to handle.
生活環境における有害物質の種類はかなり多いが、その大きな割合を占めるものの一つはタバコの煙等に多量に含まれているラジカル類、特にヒドロキシラジカル等の有害な活性酸素種である。一般的に、浄化剤としては活性炭がよく利用されている。活性炭は無極性吸着剤として極めて優れた吸着性を有する特異な材質で、殆どすべての微量のガス状物質に対して高い吸着性を示す。しかしながら、通常の活性炭では上記有害物質の中で活性酸素種、ラジカル類を十分に除去、解毒化することは困難である。 There are quite a lot of types of harmful substances in the living environment, but one of those that occupies a large proportion is radicals contained in large amounts in tobacco smoke, especially harmful active oxygen species such as hydroxy radicals. In general, activated carbon is often used as a purification agent. Activated carbon is a unique material having extremely excellent adsorptivity as a nonpolar adsorbent, and exhibits high adsorptivity to almost all trace amounts of gaseous substances. However, it is difficult for normal activated carbon to sufficiently remove and detoxify active oxygen species and radicals among the harmful substances.
また、浄化脱臭剤の一種として、硫酸鉄にアスコルビン酸を加えた製品も市販されている。この種のものは初期の有害ガス除去、脱臭性能は良好であるが持続的な能力はなく、直ぐにその能力が失われでしまうという欠点がる。その他にも化学脱臭剤として多数の提案や市販品もあるが、酸性やアルカリ性の強いものが多く、またラジカルに対してはほとんど除去・解毒作用はなく、更に吸湿または乾燥の影響を受け易い欠点を有するものが多い。たとえば、ベントナイトに無機の多塩基酸を吸着したもの（特許文献１）、ビタミンＢ１２の触媒作用によるもの（特許文献２）、金属フタロシアニンを使用するもの（特許文献３）等の他、有機系脱臭剤もあるが、いずれも耐熱性が低かったり、加工が困難で高価であったりして性能、コスト、生産の容易性などを勘案すると有効なものはほとんど見当たらないのが現状である。
また、一般にラジカル物質が生体や細胞に接触すると細胞膜や細胞質中の脂質が過酸化を受け、過酸化物質（過酸化脂質）が生成・増加するといわれている。この過酸化脂質は不安定であり、過酸化脂質ラジカルに変化しやすくこの過酸化脂質ラジカルや他のラジカルが新たな過酸化脂質を作り出すという悪循環が繰り返される。
ここで生み出された過酸化脂質ラジカルやその他のラジカルは、最終的には遺伝子に障害を与えることがあり、その結果として細胞をガン化させることがある。このラジカルが生体にとって危険である理由の一つである。生体の過酸化脂質の増加、ＴＢＡＲＳの測定法、ＴＢＡＲＳの量と発ガンとの関係については以下のような多くの公知文献がある（非特許文献１〜３参照）。
In general, it is said that when a radical substance comes into contact with a living body or a cell, lipids in the cell membrane and cytoplasm are peroxidized, and a peroxide substance (lipid peroxide) is generated and increased. This lipid peroxide is unstable and is easily converted into a lipid peroxide radical, and a vicious cycle in which the lipid peroxide radical and other radicals produce new lipid peroxide is repeated.
The lipid peroxide radicals and other radicals generated here can ultimately damage the gene, resulting in cancerous cells. This is one of the reasons why this radical is dangerous for the living body. There are many known literatures regarding the increase in lipid peroxides in the body, the TBARS measurement method, and the relationship between the amount of TBARS and carcinogenesis (see Non-Patent Documents 1 to 3).
そこで、この出願の発明は、以上のような背景から、人体内で発生する過酸化脂質の生成抑制作用に優れ、かつ安全性が高く取扱も容易で、長期間の間、過酸化脂質の生成を抑制する浄化能力を持続することのできる、新しい浄化剤を提供することを課題としている。 In view of the above, the invention of this application is excellent in suppressing the production of lipid peroxide generated in the human body, is safe and easy to handle, and produces lipid peroxide over a long period of time. It is an object to provide a new purifying agent capable of sustaining the purifying ability to suppress the above.
この出願は、上記の課題を解決するものとして、以下の発明を提供する。
[１] ポリビニルピロリドンとフラーレンとの複合体および水酸化フラーレンから選ばれる少なくとも１種を含有することを特徴とする生体の過酸化脂質の生成抑制用の浄化剤。
[２] ポリビニルピロリドンとフラーレンとの複合体および水酸化フラーレンから選ばれる少なくとも１種の含有量が多孔質物質に対して０．１〜３０重量％であることを特徴とする上記の生体の過酸化脂質の生成抑制用の浄化剤。
[３] 多孔質物質は、繊維、紙、活性炭、ゼオライト、珪藻土、多孔質樹脂、多孔質ゴム、および多孔質セラミックスのうちの少なくとも１種である上記の生体の過酸化脂質の生成抑制用の浄化剤。
[４] 多孔質物質は、水ガラス、多糖類、水溶性高分子、およびポリオール類のうちの少なくとも１種により表面処理されている上記の生体の過酸化脂質の生成抑制用の浄化剤。
This application provides the following invention as a solution to the above problems.
[1] A purifying agent for suppressing production of lipid peroxide in a living body, comprising at least one selected from a complex of polyvinylpyrrolidone and fullerene and fullerene hydroxide.
[2] A content of at least one selected from the complex of polyvinylpyrrolidone and fullerene and fullerene hydroxide is 0.1 to 30% by weight with respect to the porous material. A purifying agent for suppressing the formation of oxidized lipids.
[3] The porous substance is for suppressing the production of lipid peroxide in the living body, which is at least one of fiber, paper, activated carbon, zeolite, diatomaceous earth, porous resin, porous rubber, and porous ceramics. Purifier.
[4] The purification agent for suppressing production of lipid peroxide in the living body, wherein the porous material is surface-treated with at least one of water glass, polysaccharides, water-soluble polymers, and polyols.
この出願の発明の浄化剤は、日常の生活空間に存在する人体に有害なラジカルに対して優れた除去効果を有し、人体内で発生する過酸化物質の除去および生成抑制作用に優れ、かつ安全性が高く取扱も容易で、製造することも容易であり、また安定性に優れているため長期間の間、過酸化物質の除去および生成抑制する浄化能力を持続することができる。
このため、オフィス、車内、家庭等の生活空間におけるフィルター、微小なセル、邪魔板などの種々の形態で流動体および固体物質浄化装置に組み込み使用することができる。
The purifying agent of the invention of this application has an excellent removal effect on radicals harmful to the human body present in daily living space, is excellent in the action of removing and inhibiting the generation of peroxides generated in the human body, and It is safe, easy to handle, easy to manufacture, and excellent in stability, so that it can maintain a purification ability for removing and inhibiting peroxidation substances for a long period of time.
For this reason, it can be incorporated and used in a fluid and solid substance purification apparatus in various forms such as filters, minute cells, baffles and the like in living spaces such as offices, cars, and homes.
以下この出願の発明について詳しく説明する。 The invention of this application will be described in detail below.
まず、この出願の発明の生体の過酸化脂質の生成抑制用の浄化剤は、上記のとおりポリビニルピロリドンとフラーレンとの複合体および水酸化フラーレンから選ばれる少なくとも１種を含有する。 First, the biological cleansing agent for inhibiting production of lipid peroxide in the invention of this application contains at least one selected from the complex of polyvinylpyrrolidone and fullerene and fullerene hydroxide as described above.
この出願の発明に使用できるフラーレンとしては、フラーレンＣ６０、フラーレンＣ７０、およびこれらとカーボンナノチューブとの混合物が例示される。 Examples of fullerenes that can be used in the invention of this application include fullerene C60, fullerene C70, and mixtures of these with carbon nanotubes.
そして、これらのフラーレンやカーボンナノチューブについてはこれまでに公知とされたものを含めて各種の炭素構造をもつものが考慮されてよい。 And about these fullerene and carbon nanotube, what has various carbon structures including what was known until now may be considered.
この出願の発明に使用できる水酸化フラーレンとしては、フラーレンＣ６０、フラーレンＣ７０等の炭素数６０以上のフラーレンに置換基として水酸基を有するものが挙げられる。水酸基の数については一般的には２０以下であることが考慮される。Examples of the fullerene hydroxide that can be used in the invention of this application include those having a hydroxyl group as a substituent on a fullerene having 60 or more carbon atoms such as fullerene C60 and fullerene C70. It is considered that the number of hydroxyl groups is generally 20 or less.
この出願の発明においては、一般式（１）で表される構造を有するフラーレン類及びその誘導体（その塩を含む）を担持もしくは吸着（多孔質物質に対し、担持でも吸着でも良いので、この出願の発明では「担持・吸着」とした。）させる多孔質物質としては、たとえば活性炭、活性アルミナ、シリカゲル、ゼオライト等の無機多孔質物質、繊維、スポンジ、発泡樹脂などの有機多孔質物質が使用できる。この出願の発明において、浄化剤のための担体として使用される多孔質物質は、通常１ｇあたり１０ｍ2あるいはそれ以上の大きな表面積を有する材料が好ましく使用できる。たとえばその一例としては、活性炭があるが、該活性炭の原料としてヤシ穀、木材等の炭化物あるいは石炭からの活性炭などが使用されるが何れでもよい。また賦活法も水蒸気あるいは二酸化炭素により高温で賦活する方法、あるいは塩化亜鉛、リン酸、濃硫酸等の化学薬品で処理する方法等、多くの方法があるが、この出願の発明の担体としてはそのいづれの方法によって得られたものであってもよい。 In the invention of this application, fullerenes having a structure represented by the general formula (1) and derivatives thereof (including salts thereof) are supported or adsorbed (supported or adsorbed on a porous material). In the present invention, “supported / adsorbed” is used.) As the porous material to be used, for example, inorganic porous materials such as activated carbon, activated alumina, silica gel and zeolite, and organic porous materials such as fibers, sponges and foamed resins can be used. . In the invention of this application, as the porous substance used as a carrier for the cleaning agent, a material having a large surface area of usually 10 m 2 or more per gram can be preferably used. For example, as an example, activated carbon is used. As a raw material of the activated carbon, a carbonized material such as coconut cereal and wood, activated carbon from coal, or the like may be used. In addition, there are many activation methods such as a method of activating at a high temperature with water vapor or carbon dioxide, or a method of treating with chemicals such as zinc chloride, phosphoric acid, concentrated sulfuric acid, etc. It may be obtained by any method.
また活性炭としての形状は、破砕炭、造粒炭あるいは顆粒炭の何れでも効果は認められるが、圧損失や浄化剤の入替等、取扱いのし易さを考慮すると造粒炭または活性炭を多孔質物質担体に担持もしくは吸着したシート状吸着層が便利である。造粒炭は常法に従って、活性炭材料１００部に３０〜６０部の石油ピッチあるいはコールタール等をバインダーとして加え、混和し、成型後賦活して調製される。なお、活性炭以外の多孔質物質としては、たとえばゼオライト、アルミナ、シリカゲル、軽石、ウレタンフォーム、繊維、紙、布など、多孔質のものであれば広範囲に使用できる。これらの多孔質物質の形状は特に限定しないが、たとえば、粒状、粉末状の他に、繊維状、ハニカム状、シート状、布状、フェルト状あるいは粉末状多孔質物質をウレタンフォーム等に担持・吸着したもの、粉末状多孔質物質をコーティングした紙をコルゲート状にしてハニカム構造として取扱性を改善した流動体及び固体物質浄化用フィルターあるいはカートリッジ（この出願の発明においてはこれらフラーレン及びその誘導体を多孔質物質に担持し、これを成型したものを一括して「流動体及び固体物質浄化用フィルター」という。）が使用できる。 In addition, the activated carbon is effective for either crushed coal, granulated coal, or granulated coal. However, considering the ease of handling such as pressure loss and replacement of purifier, granulated coal or activated carbon is porous. A sheet-like adsorption layer supported or adsorbed on a substance carrier is convenient. Granulated coal is prepared by adding 30 to 60 parts of petroleum pitch or coal tar as a binder to 100 parts of activated carbon material as a binder, mixing, and activating after molding according to a conventional method. In addition, as a porous substance other than activated carbon, for example, a porous substance such as zeolite, alumina, silica gel, pumice, urethane foam, fiber, paper, and cloth can be used in a wide range. The shape of these porous materials is not particularly limited. For example, in addition to granules and powders, fibrous, honeycomb, sheet, cloth, felt or powdery porous materials are supported on urethane foam, etc. A fluid and solid substance purification filter or cartridge in which the adsorbed one, paper coated with a powdery porous substance is corrugated to improve the handleability as a honeycomb structure (in the invention of this application, these fullerenes and derivatives thereof are made porous. A material obtained by supporting a material and molding it can be collectively referred to as a “fluid and solid material purification filter”).
これらの多孔質物質の表面には水ガラス、ヒアルロン酸、澱粉、セルロース等の多糖類、カーボポール、ポリエチレングリコール、プロピレングリコール、ブチレングリコール、ポリアクリル酸等の水溶性高分子等やグリセリンから選択される単体またはその複合物のポリオール類を表面処理しこれらの物質中にこの出願の発明のフラーレン類やその誘導体を含有するとラジカルの反応性が高まりより効率的にラジカル類を消去できる。 The surface of these porous substances is selected from water glass, polysaccharides such as hyaluronic acid, starch and cellulose, water-soluble polymers such as carbopol, polyethylene glycol, propylene glycol, butylene glycol and polyacrylic acid, and glycerin. If the polyols of a simple substance or a composite thereof are surface-treated and the fullerenes or derivatives thereof of the invention of this application are contained in these substances, the reactivity of the radicals is increased and the radicals can be more efficiently eliminated.
多孔質物質に対するフラーレン類及びその誘導体の担持・吸着量は、好ましくは各々０．００１〜５０．０重量％、より好ましくは０．１〜３０重量％てある。担持・吸着量が０．１重量％より少ないとフラーレン類及びその誘導体の有害性物質の吸着・解毒性能が乏しく、また担持・吸着量が５０．０重量％を越えると多孔質物質の吸着性が阻害されるためである。 The amount of fullerenes and their derivatives supported and adsorbed on the porous material is preferably 0.001 to 50.0% by weight, more preferably 0.1 to 30% by weight. Adsorption / detoxification performance of harmful substances such as fullerenes and their derivatives is poor when the loading / adsorption amount is less than 0.1% by weight, and adsorption of porous materials when the loading / adsorption amount exceeds 50.0% by weight. It is because is inhibited.
また、この出願の発明の浄化剤には、ポリビニルピロリドンとフラーレンとの複合体および水酸化フラーレンから選ばれる少なくとも１種以外のラジカルスカベンジング剤を含有させるようにしてもよい。このようなラジカルスカベンジング剤としては、Ｌ−アスコルビン酸−２−リン酸エステルマグネシウム塩、Ｌ−アスコルビン酸−２−リン酸エステルナトリウム塩、Ｌ−アスコルビン酸−２−リン酸エステル亜鉛塩、Ｌ−アスコルビン酸−２−リン酸エステルカルシウム塩、Ｌ−アスコルビン酸−２−リン酸エステルカリウム塩、Ｌ−アスコルビン酸−２−リン酸エステルカリウムカルシウム塩、Ｌ−アスコルビン酸−２−リン酸エステルマグネシウムカリウム塩、Ｌ−アスコルビン酸−２−リン酸エステルアルミニウム塩、Ｌ−アスコルビン酸−２−リン酸エステルチタン塩、Ｌ−アスコルビン酸−２−ジリン酸エステルナトリウム塩、Ｌ−アスコルビン酸−２−トリリン酸エステルナトリウム塩、Ｌ−アスコルビン酸−２−グルコシド、Ｌ−アスコルビン酸−２−リン酸エステル−６−パルミテートマグネシウム塩、Ｌ−アスコルビン酸−２−リン酸エステル−６−パルミテートナトリウム塩、Ｌ−アスコルビン酸−２−グルコシド−６−パルミテート、Ｌ−アスコルビン酸−２−リン酸エステルナトリウムマグネシウム塩、Ｌ−アスコルビン酸−２−硫酸エステルナトリウム塩、Ｌ−アスコルビン酸−３−リン酸エステルマグネシウム塩、Ｌ−アスコルビン酸−３−リン酸エステルナトリウム塩、Ｌ−アスコルビン酸−３−リン酸エステル亜鉛塩、Ｌ−アスコルビン酸−３−リン酸エステルカルシウム塩、Ｌ−アスコルビン酸−３−リン酸エステルカリウム塩、Ｌ−アスコルビン酸−３−リン酸エステルカリウムカルシウム塩、Ｌ−アスコルビン酸−３−リン酸エステルマグネシヴムカリウム塩、Ｌ−アスコルビン酸−３−リン酸エステルアルミニウム塩、Ｌ−アスコルビン酸−３−リン酸エステルチタン塩、Ｌ−アスコルビン酸−３−ジリン酸エステルナトリウム塩、Ｌ−アスコルビン酸−３−トリリン酸エステルナトリウム塩、Ｌ−アスコルビン酸−３−グルコシド、Ｌ−アスコルビン酸−３−リン酸エステル−６−パルミテートマグネシウム塩、Ｌ−アスコルビン酸−３−リン酸エステル−６−パルミテートナトリウム塩、Ｌ−アスコルビン酸−３−グルコシド−６−パルミテート、Ｌ−アスコルビン酸−３−リン酸エステルナトリウムマグネシウム塩、Ｌ−アスコルビン酸−２，３，５，６−テトライソパルイトイル、Ｌ−アスコルビン酸−２，３，５，６−テトラパルイトイル、Ｌ−アスコルビン酸−３−硫酸エステルナトリウム塩、ｄｌ−α−トコフェロール、ｄｌ−α−トコフェロール酢酸エステル、ｄｌ−α−トコフェロールリン酸ナトリウム塩、カリウム塩、マグネシウム塩、カルシウム塩などの金属塩、ｄｌ−α−トコフェロール酢酸エステル、ビタミンＥニコチネート等のビタミンＥ及びその誘導体、ユビキノン、エリソルビン酸、茶抽出物、ポリフェノール類、エトキシキンなどの酸化防止剤、アスタキサンチン等のカロチノイド類、カテキン等のポリフェノール等から選択されるが、中でもカロチン、アスタキサンチン、ルテイン、ｄｌ−α−トコフニロール酢酸エステル、α−トコフェロール、ＳＯＤ、αリポ酸、システイン、グルタチオン、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、没食子酸プロピル、キカテキン類またはこれら全てのナトリウム、カリウム、マグネシウム、カルシウム等のアルカリ金属、アルカリ土類金属塩から選択される一種以上の物質等が挙げられる。 Moreover, you may make it contain the radical scavenging agent other than at least 1 sort (s) chosen from the composite_body | complex of polyvinylpyrrolidone and fullerene, and the fullerene hydroxide in the purification agent of invention of this application. Examples of such radical scavenging agents include L-ascorbic acid-2-phosphate magnesium salt, L-ascorbic acid-2-phosphate sodium salt, L-ascorbic acid-2-phosphate zinc salt, L -Ascorbic acid-2-phosphate calcium salt, L-ascorbic acid-2-phosphate potassium salt, L-ascorbic acid-2-phosphate potassium calcium salt, L-ascorbic acid-2-phosphate magnesium Potassium salt, L-ascorbic acid-2-phosphate aluminum salt, L-ascorbic acid-2-phosphate titanium salt, L-ascorbic acid-2-diphosphate sodium salt, L-ascorbic acid-2-trilin Acid ester sodium salt, L-ascorbic acid-2-glucoside L-ascorbic acid-2-phosphate-6-palmitate magnesium salt, L-ascorbic acid-2-phosphate-6-palmitate sodium salt, L-ascorbic acid-2-glucoside-6-palmitate, L -Ascorbic acid-2-phosphate sodium magnesium salt, L-ascorbic acid-2-sulfate sodium salt, L-ascorbic acid-3-phosphate magnesium salt, L-ascorbic acid-3-phosphate sodium salt L-ascorbic acid-3-phosphate zinc salt, L-ascorbic acid-3-phosphate calcium salt, L-ascorbic acid-3-phosphate potassium salt, L-ascorbic acid-3-phosphate Potassium calcium salt, L-ascorbic acid-3-phosphate ester Nesivum potassium salt, L-ascorbic acid-3-phosphate aluminum salt, L-ascorbic acid-3-phosphate titanium salt, L-ascorbic acid-3-diphosphate sodium salt, L-ascorbic acid-3-trilin Acid ester sodium salt, L-ascorbic acid-3-glucoside, L-ascorbic acid-3-phosphate-6-palmitate magnesium salt, L-ascorbic acid-3-phosphate-6-palmitate sodium salt, L-ascorbic acid-3-glucoside-6-palmitate, L-ascorbic acid-3-phosphate sodium magnesium salt, L-ascorbic acid-2,3,5,6-tetraisopalitoyl, L-ascorbic acid -2,3,5,6-tetrapalitoyl, L-ascorbic acid-3 -Sulfate ester sodium salt, dl-α-tocopherol, dl-α-tocopherol acetate ester, dl-α-tocopherol phosphate sodium salt, potassium salt, magnesium salt, calcium salt and other metal salts, dl-α-tocopherol acetate ester Vitamin E and derivatives thereof such as vitamin E nicotinate, ubiquinone, erythorbic acid, tea extract, polyphenols, antioxidants such as ethoxyquin, carotenoids such as astaxanthin, polyphenols such as catechin, etc. , Astaxanthin, lutein, dl-α-tocofrolol acetate, α-tocopherol, SOD, α lipoic acid, cysteine, glutathione, dibutylhydroxytoluene, butylhydroxyanisole, propyl gallate, key Catechins or sodium all of these, potassium, magnesium, alkali metals such as calcium, one or more substances selected from alkaline earth metal salts.
一般にラジカル物質が、生体や細胞に接触すると細胞膜や細胞質中の脂質が過酸化を受け、過酸化脂質が生成・増加するといわれている。この過酸化脂質は不安定であり、過酸化脂質ラジカルに変化しやすくこの過酸化脂質ラジカルや他のラジカルが新たな過酸化脂質を作り出すという悪循環が繰り返される。ここで生み出された過酸化脂質ラジカルやその他のラジカルは、最終的には遺伝子に障害を与えることがあり、その結果として細胞をガン化させることがある。このラジカルが生体にとって危険である理由の一つである。生体の過酸化脂質の増加、ＴＢＡＲＳの測定法、ＴＢＡＲＳの量と発ガンとの関係については以下のような多くの公知文献がある（非特許文献１〜３）。 In general, when a radical substance comes into contact with a living body or a cell, lipids in the cell membrane and cytoplasm are peroxidized, and lipid peroxide is generated and increased. This lipid peroxide is unstable and is easily converted into a lipid peroxide radical, and a vicious cycle in which the lipid peroxide radical and other radicals produce new lipid peroxide is repeated. The lipid peroxide radicals and other radicals generated here can ultimately damage the gene, resulting in cancerous cells. This is one of the reasons why this radical is dangerous for the living body. There are many well-known literatures regarding the increase in lipid peroxide in the body, the TBARS measurement method, and the relationship between the amount of TBARS and carcinogenesis (Non-Patent Documents 1 to 3) .
したがって流動体及び固体物質中のラジカルの影響を調べるためには、生物体内の過酸化物の量を測定することにより調べることができ、一般的には流動体及び固体物質の影響を最も受けやすい肺の組織中の過酸化物の量をＴＢＡＲＳの測定によって追跡することができると考えられる。つまり、環境流動体及び固体物質中のラジカルの量が増えれば肺呼吸を行っている生物の肺組織中のＴＢＡＲＳの量を追跡することにより、環境流動体及び固体物質中のラジカルの量を追跡できると考えられる。 Therefore, in order to investigate the influence of radicals in fluids and solid substances, it can be examined by measuring the amount of peroxide in the organism, and is generally most susceptible to influences of fluids and solid substances. It is believed that the amount of peroxide in the lung tissue can be followed by measuring TBARS. In other words, if the amount of radicals in the environmental fluid and solid material increases, the amount of radicals in the environmental fluid and solid material is tracked by tracking the amount of TBARS in the lung tissue of the organism that is breathing lungs. It is considered possible.
多孔質物質に対するこの出願の発明のフラーレン類及びその誘導体以外のラジカルスカベンジング剤の担持・吸着量は、好ましくは各々０．００１〜５０．０重量％、より好ましくは０．１〜３０重量％である。担持・吸着量が０．１重量％より少ないとその効果が乏しく、また担持・吸着量が５０．０重量％を越えると多孔質物質の吸着性が阻害されるため流動体及び固体物質の浄化剤としての有害物質の除去・吸着性能が落ちる。この出願の発明の流動体及び固体物質の浄化剤には、流動体及び固体物質の浄化剤に通常添加される副剤を同時に一つまたは複数添加することもできる。この出願の発明に添加できる副剤とは以下の物があげられるが、通常多孔質材料に対し０．０００１〜５０重量％の割合で添加することができる。 The loading / adsorption amount of radical scavenging agents other than the fullerenes of the invention of this application and derivatives thereof with respect to the porous material is preferably 0.001 to 50.0% by weight, more preferably 0.1 to 30% by weight, respectively. It is. If the supported / adsorbed amount is less than 0.1% by weight, the effect is poor. If the supported / adsorbed amount exceeds 50.0% by weight, the adsorptivity of the porous material is hindered, so the fluid and solid materials are purified. The performance of removing and adsorbing harmful substances as agents is reduced. In the fluid and solid substance purifying agent of the invention of this application, one or more auxiliary agents that are usually added to the fluid and solid substance purifying agent can be added simultaneously. Examples of the auxiliary agent that can be added to the invention of this application include the following, and it can be usually added at a ratio of 0.0001 to 50% by weight based on the porous material.
この出願の発明で使用できる副剤としては、たとえば、のり、メチルセルロース、接着樹脂などの接着剤、エリソルビンサンなどの安定剤、バラベン、イソフタロニトリル誘導体などの抗菌剤、水ガラス、ポリアクリル酸ソーダなどのバインダー、シリカ、珪藻土などの増量剤、青色６号などの着色剤、次亜塩素酸ソーダなどの脱色剤、ＳＤＳなどの界面活性剤、グリセリンなどの保湿剤などである。 Examples of the auxiliary agent that can be used in the invention of this application include glue, methylcellulose, adhesives such as adhesive resins, stabilizers such as erythorbin sun, antibacterial agents such as baraben and isophthalonitrile derivatives, water glass, and sodium polyacrylate. Binders such as silica and diatomaceous earth, colorants such as blue No. 6, decolorizing agents such as sodium hypochlorite, surfactants such as SDS, and humectants such as glycerin.
この出願の発明の生体の過酸化脂質の生成抑制用の浄化剤を調製するには、ポリビニルピロリドンとフラーレンとの複合体および水酸化フラーレンから選ばれる少なくとも１種と必要に応じてその他のラジカルスカベンジング剤とを予め多孔質物質に所定量担持もしくは吸着しておき、その後所定量の副剤を担持・吸着するのがよい。具体的にはポリビニルピロリドンとフラーレンとの複合体および水酸化フラーレンから選ばれる少なくとも１種を吸着法や振りかけ法で多孔体に担持・吸着させ、その後これに副剤を振りかけて所定量担持・吸着した後、これを１００℃以上の温度で乾燥して調製できる。これらの流動体及び固体物質の浄化剤単独でまたはこれに新しい活性炭を混合することにより、この出願の発明の浄化剤が得られる。いずれの方法によってポリビニルピロリドンとフラーレンとの複合体および水酸化フラーレンから選ばれる少なくとも１種を多孔質物質に担持・吸着した浄化剤も、ラジカル物質に対して充分な除去・吸着性能を示す。この浄化剤を１２０℃にまで加熱しても、ポリビニルピロリドンとフラーレンとの複合体および水酸化フラーレンの分解はみられず、ラジカルの除去・吸着性能の低下も認められなかった。 In order to prepare the cleaning agent for suppressing production of lipid peroxide in the living body of the invention of this application, at least one selected from a complex of polyvinylpyrrolidone and fullerene and fullerene hydroxide and other radical scavenges as necessary It is preferable to carry or adsorb a predetermined amount of a bonding agent on the porous material in advance, and then carry and adsorb a predetermined amount of the auxiliary agent. Specifically, at least one selected from a complex of polyvinyl pyrrolidone and fullerene and fullerene hydroxide is supported and adsorbed on the porous material by an adsorption method or a sprinkling method, and then a predetermined amount is supported and adsorbed by sprinkling the adjunct. Then, it can be prepared by drying at a temperature of 100 ° C. or higher. The purification agent of the invention of this application can be obtained by using these fluid and solid substance purification agents alone or by mixing them with fresh activated carbon. The purifying agent that supports and adsorbs at least one selected from the complex of polyvinylpyrrolidone and fullerene and the fullerene hydroxide on the porous material by any method exhibits sufficient removal and adsorption performance for the radical material. Even when this cleaning agent was heated to 120 ° C., the decomposition of the complex of polyvinyl pyrrolidone and fullerene and the fullerene hydroxide was not observed, and no reduction in radical removal / adsorption performance was observed.
オフィス、家庭等生活空間の室内では、タバコを吸う人がいる時にはラジカルが多い傾向にあるが、それ以外にも室内の流動体及び固体物質中に含まれている有害物質としてはラジカルの他、アンモニア、ホルマリン等がある。この出願の発明の流動体及び固体物質の浄化剤には一般式（１）で表される構造を有するフラーレン及びその誘導体やラジカルスカベンジング剤を担持・吸着した多孔質物質の他に、これに活性炭を混合した流動体及び固体物質の浄化剤とすることもできるため、有害成分のアンモニア、ホルマリン、炭化水素、硫化水素等の成分に対する吸着・除去も可能であり、流動体及び固体物質の浄化剤として優れた機能を持っている。この出願の発明の流動体及び固体物質の浄化剤はオフィス、車内、家庭等の生活空間に含まれている殆ど全ての有害物質の除去・吸着性に優れ、また吸着速度も早いため、フィルター、微小なセル、邪魔板などの流動体及び固体物質浄化用フィルターとして、種々な形態で流動体及び固体物質浄化装置に組み込み、流動体及び固体物質浄化に使用することができる。また、これらの流動体及び固体物質浄化用フィルターは、当然据え置きタイプ、カートリッジ式等あらゆる流動体及び固体物質浄化用フィルターに応用可能であり、これらの流動体及び固体物質浄化用フィルターを内蔵したエアコン、流動体及び固体物質浄化機、ドラフト、換気扇等に応用することができる。 In the indoor space of offices, homes, etc., there is a tendency for radicals to be high when there are people who smoke, but in addition to radicals as other harmful substances contained in indoor fluids and solid substances, There are ammonia and formalin. In addition to the porous material carrying and adsorbing fullerene having a structure represented by the general formula (1) and its derivatives and radical scavenging agents, the fluid and solid material purifying agent of the invention of this application include: Because it can be used as a fluid and solid substance purification agent mixed with activated carbon, it can also adsorb and remove harmful components such as ammonia, formalin, hydrocarbons, hydrogen sulfide, etc. Has an excellent function as an agent. The fluid and solid substance purifying agent of the invention of this application is excellent in the removal and adsorption of almost all harmful substances contained in living spaces such as offices, cars, and homes, and has a high adsorption speed. As filters for purifying fluids and solid substances such as minute cells and baffle plates, they can be incorporated into fluid and solid substance purification devices in various forms and used for purification of fluids and solid substances. In addition, these fluid and solid substance purification filters can naturally be applied to any fluid and solid substance purification filters such as stationary types and cartridge types, and air conditioners incorporating these fluids and solid substance purification filters. It can be applied to fluid and solid substance purifiers, drafts, ventilation fans and the like.
この出願の発明では、以上のことから、上記の浄化剤、これを用いた浄化フィルター、そして浄化パネル等を用いての配送用の装置、機器またはそれらの部材が提供されることになる。たとえば、これらの装置、機器、部材としては、プロペラ、扇風機、送風機、ドライヤー、配送ダクト、パイプ、煙突、ノズル、蛇口、サイクロン、エアコン、ダンパー、バルブ、ポンプ等が例示される。 In the invention of this application, the above-described purifying agent, a purifying filter using the purifying agent, a device for delivery using a purifying panel and the like, or members thereof are provided. For example, examples of these devices, devices, and members include propellers, fans, blowers, dryers, delivery ducts, pipes, chimneys, nozzles, faucets, cyclones, air conditioners, dampers, valves, pumps, and the like.
そこで以下に実施例を示し、さらに詳しく説明する。もちろん以下の例によって発明が限定されることはない。 Therefore, an example will be shown below and will be described in more detail. Of course, the invention is not limited by the following examples.
（フィルターＡの製造）
５０ｃｃの精製水に、ミックスフラーレン（Ｃ６０を６０％重量以上、Ｃ７０を１０％以上含有する混合物）をＰＶＰ（ポリビニルピロリドン）９９％重量に対して１％重量の割合で分散させたもの（以下ＭＦという）３％を溶解する。次に４０ｃｍ×４０ｃｍの不織布にＭＦの３％溶液５０ｃｃを均一に噴霧し、同様にして同じ物を３枚作り、これを乾燥後、三枚重ねにする。市販エアコンの交換用フィルターを取り出し既についている不織布をはずし、上記で作成したＭＦ含有不織布を均一に貼りつけ、これをフィルターとした。これをエアコンに取り付け、この出願の発明の生体の過酸化脂質の生成抑制用の浄化剤のフィルター付エアコンとした。
(Manufacture of filter A)
Mixed fullerene (mixture containing 60% by weight or more of C60 and 10% or more of C70) in 50 cc of purified water at a ratio of 1% by weight to 99% by weight of PVP (polyvinylpyrrolidone) (hereinafter referred to as MF) 3% is dissolved. Next, 50 cc of a 3% solution of MF is uniformly sprayed onto a 40 cm × 40 cm non-woven fabric to produce three identical products in the same manner, and after drying, three layers are stacked. A replacement filter for a commercial air conditioner was taken out and the nonwoven fabric already attached was removed, and the MF-containing nonwoven fabric created above was uniformly applied, and this was used as a filter. This was attached to an air conditioner to provide an air conditioner with a filter of a purifying agent for suppressing production of lipid peroxide in the living body of the invention of this application.
（フィルターＢの製造）
５０ｃｃの精製水に、ＭＦ３％及びラジカルスカベンジング剤としてｄｌ−α−トコフェロールリン酸ナトリウム１％とエピガロカテキンガレート０．０１％及び副剤の保湿剤としてグリセリン１％を溶解する。次に４０ｃｍ×４０ｃｍの不織布にＭＦなどの溶液５０ｃｃを均一に噴霧し、同様にして同じ物を３枚作り、これを乾燥後、三枚重ねにする。市販エアコンの交換用フィルターを取り出し既についている不織布をはずし、上記で作成したＭＦ含有不織布を均一に貼りつけ、これをフィルターとした。これをエアコンに取り付け、この出願の発明の生体の過酸化脂質の生成抑制用の浄化剤のフィルター付エアコンとした。
(Manufacture of filter B)
In 50 cc of purified water, 3% of MF, 1% of dl-α-tocopherol sodium phosphate and 0.01% of epigallocatechin gallate as a radical scavenging agent, and 1% of glycerin as a humectant as an auxiliary agent are dissolved. Next, 50 cc of a solution such as MF is uniformly sprayed onto a 40 cm × 40 cm non-woven fabric, and three identical products are made in the same manner. A replacement filter for a commercial air conditioner was taken out and the nonwoven fabric already attached was removed, and the MF-containing nonwoven fabric created above was uniformly applied, and this was used as a filter. This was attached to an air conditioner to provide an air conditioner with a filter of a purifying agent for suppressing production of lipid peroxide in the living body of the invention of this application.
（実施例１）ウェスター系ラット雄３０匹を１０匹ずつ２対照区（１区及び２区）と２試験区（３区及び４区）の４群に分け、そのゲージはそれぞれ別々に三菱電機（株）製エアコン（商品名：「霧が峰」）が設置された縦３．５ｍ×横２．８ｍ×高さ３．１ｍの室内に置かれた。エアコンのフィルターとして、試験区３区には上記のように製造されたフィルターＡを取り付け、試験区４区には上記のように製造されたフィルターＢを取りつけた。２つの対照区（１区及び２区）にはＭＦが担持・吸着されていない同型のフィルターを取り付けた。このエアコンで送風のみを行い、１週間に亙って連続運転した。この間対照区１区、試験区３区及び試験区４区には一日当たり２０本の喫煙を成人男性がこの室内に入って行った。対照区２区のみ契煙を行わなかった。毎日１回エアコンフィルターを同じ物と交換し、ラットの餌、水は自由給餌させた。１週間後ラットの肺を取り出しMasugi and Nakamuraの方法により肺のＴＢＡＲＳ（過酸化物価）を測定しその平均値を求めた。その結果を以下の表１に示す。 (Example 1) Thirty Wester rats were divided into 4 groups of 2 control groups (1 and 2) and 2 test groups (3 and 4), each of which had 10 male rats. It was placed in a room 3.5 m long × 2.8 m wide × 3.1 m high where an air conditioner manufactured by Denki Co., Ltd. (trade name: “Kirigamine”) was installed. As an air conditioner filter, the filter A manufactured as described above was attached to the test section 3, and the filter B manufactured as described above was attached to the test section 4. Two control groups (1st and 2nd) were equipped with the same type of filter on which MF was not supported or adsorbed. Only air was blown with this air conditioner, and continuous operation was performed for one week. During this time, adult males smoked 20 cigarettes per day in the control zone 1, the test zone 3 and the test zone 4 ward. Only the control ward 2 did not smoke. The air conditioner filter was replaced with the same one once a day, and the rats were allowed to freely feed food and water. One week later, the lungs of the rat were taken out, and the lung TBARS (peroxide value) was measured by the method of Masugi and Nakamura, and the average value was obtained. The results are shown in Table 1 below.
（実施例２）
実施例１のＭＦ３％水溶液をチューブの内面に１ｇ／１０平方センチの密度でスプレー、乾燥させラジカルスカベンジング用流動体及び固体チューブとした。
（実施例３）
実施例１のＭＦ３％水溶液をダクトの内面に１ｇ／10平方センチの密度でスプレー、乾燥させラジカルスカベンジング用流動体及び固体ダクトとした。
（実施例４）
実施例１のＭＦ３％水溶液をプロペラの両面に１ｇ／１０平方センチの密度でスプレして乾燥させラジカルスカベンジング用流動体及び固体プロペラとした。
（実施例５）
実施例１のＭＦを水ガラスに３％重量濃度で均一に分散させこれを焼却炉煙突の内側に１ｇ／１０平方センチの密度でコーティングしてラジカルスカベンジング用排煙煙突とした。
（実施例６）
実施例１のＭＦを水ガラスに３％重量濃度で均一に分散させこれを直径５ｍｍ、長さ２０ｃｍのステンレス製細間パイプの内側に０．１ｇ／１０平方センチの密度でコーティングしこれを５０本束ねてステンレスパイプに納めラジカルスカベンジング用水道管用フィルターとした。
（実施例７）
実施例１のＭＦを水ガラスに３％重量濃度で均一に分散させこれを流動体及び固体噴出ノズルの内側に１ｇ／１０平方センチの密度でコーティングしてラジカルスカベンジング用流動体及び固体噴出ノズルとした。
（実施例８）
実施例１のＭＦを水ガラスに３％重量濃度で均一に分散させこれを熱交換パネルの表面に１ｇ／10平方センチの密度でコーティングしてラジカルスカベンジング用熱交換パネルとした。
（実施例９）
実施例１のＭＦを水ガラスに３％重量濃度で均一に分散させこれをシャワーノズルの内側に１ｇ／１０平方センチの密度でコーティングしてラジカルスカベンジング用シャワーノズルとした。
（実施例１０）
実施例９において、ＭＦに代えて、水酸化フラーレンＣ６０（平均分子量９５８．７／粉体（水溶性固体）、水酸化率１４ＯＨ基／molecule）を用いてコーティングしてラジカルスカンベンジング用シャワーノズルとした。
（実施例１１）
実施例６において、実施例９で用いた水酸化フラーレンでコーティングし、水道管用フィルターとした。
(Example 2)
The aqueous MF 3% solution of Example 1 was sprayed on the inner surface of the tube at a density of 1 g / 10 square centimeter and dried to obtain a radical scavenging fluid and a solid tube.
(Example 3)
The MF3% aqueous solution of Example 1 was sprayed on the inner surface of the duct at a density of 1 g / 10 square centimeter and dried to obtain a radical scavenging fluid and a solid duct.
Example 4
The MF3% aqueous solution of Example 1 was sprayed on both sides of the propeller at a density of 1 g / 10 cm 2 and dried to obtain a radical scavenging fluid and a solid propeller.
(Example 5)
The MF of Example 1 was uniformly dispersed in water glass at a concentration of 3% by weight, and this was coated on the inside of the incinerator chimney at a density of 1 g / 10 square centimeters to obtain an exhaust chimney for radical scavenging.
(Example 6)
The MF of Example 1 was uniformly dispersed in water glass at a concentration of 3% by weight, and this was coated at a density of 0.1 g / 10 square centimeter on the inside of a stainless steel narrow pipe having a diameter of 5 mm and a length of 20 cm. This bundle was bundled into a stainless steel pipe and used as a water pipe filter for radical scavenging.
(Example 7)
The MF of Example 1 was uniformly dispersed in water glass at a concentration of 3% by weight, and this was coated on the inside of the fluid and solid ejection nozzles at a density of 1 g / 10 square centimeters to provide a radical scavenging fluid and solid ejection nozzles. It was.
(Example 8)
The MF of Example 1 was uniformly dispersed in water glass at a concentration of 3% by weight, and this was coated on the surface of the heat exchange panel at a density of 1 g / 10 square centimeters to obtain a heat exchange panel for radical scavenging.
Example 9
The MF of Example 1 was uniformly dispersed in water glass at a concentration of 3% by weight, and this was coated on the inside of the shower nozzle at a density of 1 g / 10 square centimeter to obtain a shower nozzle for radical scavenging.
(Example 10)
In Example 9, instead of MF, a shower nozzle for radical scavenging coated with hydroxylated fullerene C60 (average molecular weight 958.7 / powder (water-soluble solid), hydroxylation rate 14OH group / molecule). It was.
(Example 11)
In Example 6, it coated with the hydroxylation fullerene used in Example 9, and it was set as the filter for water pipes.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004087894A JP4827384B2 (en) | 2004-03-24 | 2004-03-24 | Purifying agent for inhibiting the formation of lipid peroxides in the body |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004087894A JP4827384B2 (en) | 2004-03-24 | 2004-03-24 | Purifying agent for inhibiting the formation of lipid peroxides in the body |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2005270804A JP2005270804A (en) | 2005-10-06 |
| JP4827384B2 true JP4827384B2 (en) | 2011-11-30 |
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| JP2004087894A Expired - Lifetime JP4827384B2 (en) | 2004-03-24 | 2004-03-24 | Purifying agent for inhibiting the formation of lipid peroxides in the body |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7537695B2 (en) * | 2005-10-07 | 2009-05-26 | Pur Water Purification Products, Inc. | Water filter incorporating activated carbon particles with surface-grown carbon nanofilaments |
| US20070258879A1 (en) * | 2005-12-13 | 2007-11-08 | Philip Morris Usa Inc. | Carbon beads with multimodal pore size distribution |
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| DE4419981A1 (en) * | 1994-06-08 | 1995-12-14 | Hoechst Ag | Process for the preparation of fullerene inclusion compounds |
| JPH08164309A (en) * | 1994-12-14 | 1996-06-25 | Mitsubishi Heavy Ind Ltd | Air purifying filter, device and method thereof |
| JP2000288387A (en) * | 1999-04-05 | 2000-10-17 | Showa Denko Kk | Air cleaning agent and air cleaning tool |
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