JP4816218B2 - Depressurized blood collection tube - Google Patents

Description

  The present invention relates to a reduced pressure blood collection tube. Specifically, the vacuum blood collection tube for collecting a blood sample includes a container body having an opening at an upper end and a lid member attached to the opening, and the lid member seals the opening. A plug body provided with an elastic member at least in the central part, and a barrier member provided on the upper part of the plug body, wherein at least the central part of the top surface of the plug body is separated from the central part of the lower surface of the barrier member. The present invention relates to a reduced pressure blood collection tube.

  Depressurized blood collection tubes and blood collection tube holders are widely used as medical instruments for collecting blood samples for testing blood components. As a general example of the decompression blood collection tube, those disclosed in Patent Documents 1 to 4 are exemplified and practiced as a business. However, these blood collection tubes have a problem that since the plug body is thick, the piercing resistance is high and the handling is difficult.

  As what solves the said subject, the film seal | sticker type currently disclosed by patent document 5 is implemented as a business. The film seal type includes a thin rubber stopper at the center of the film seal, and has a low piercing resistance and is easy to handle.

  However, in any of the above-described reduced-pressure blood collection tubes, a blood pool is formed on the surface of the stopper when the needle of the blood collection tube holder is pulled out after blood collection. A blood pool is formed when blood stored in a vacuum blood collection tube leaks through a puncture hole formed by piercing a needle to the plug body surface by capillary action.

  Furthermore, when the needle pierced through the stopper is pulled out, the blood adhering to the side wall of the needle is wiped off by the restoring force of the rubber, but the blood may remain at the needle tip. In particular, the puncture of the decompression blood collection tube through the stopper is achieved by a needle provided in the blood collection tube holder, and this needle is covered with a rubber member for the purpose of preventing needle puncture accidents. That is, if the rubber member is restored with blood remaining on the needle tip, the remaining blood may be scattered.

  There is a concern that the leaked or scattered blood described above may cause nosocomial infections.

Japanese Patent Laid-Open No. 02-041141 Japanese Patent Laid-Open No. 06-194280 JP 09-253074 A JP 2000-139882 A Japanese Patent Laid-Open No. 06-189944

  Accordingly, there is a need to provide a vacuum blood collection tube that prevents the formation of a blood pool on the surface of the plug body and the remaining of blood at the needle tip when the needle pierced through the plug body is pulled out.

The present invention
[1] A vacuum blood collection tube for collecting a blood sample,
A container body having an opening at the upper end, and a lid member attached to the opening,
The lid member includes a plug body that seals the opening and includes an elastic member at least in a central portion, and a barrier member that is provided in an upper portion of the plug body. A reduced pressure blood collection tube characterized by being spaced apart from the center of the lower surface of the barrier member,
[2] The reduced-pressure blood collection tube according to [1], wherein the lid member further includes a holding unit that holds the stopper and the barrier member.
[3] The reduced-pressure blood collection tube according to [1], wherein a central part of the top surface of the plug body has a concave recess at the bottom.
[4] The reduced-pressure blood collection tube according to [1], further comprising a spacer between the plug and the barrier member,
[5] The reduced pressure blood collection tube according to [1], wherein a distance between a central portion of the top surface of the stopper and a central portion of the lower surface of the barrier member is 1 mm or more.
[6] The reduced-pressure blood collection tube according to [1], wherein a distance between a central portion of the top surface of the stopper and a central portion of the bottom surface of the barrier member is 1 to 5 mm.
And [7] a vacuum blood collection tube for collecting a blood sample,
A container body having an opening at the upper end, and a lid member attached to the opening,
The lid member includes a plug body that seals the opening and includes an elastic member at least in a central portion, and a barrier member that is provided in an upper portion of the plug body. Provided is a vacuum blood collection tube in which a space is formed between the central portion of the lower surface of a barrier member.

  According to the reduced pressure blood collection tube of the present invention, when the needle of the blood collection tube holder is pulled out after blood collection, it is possible to prevent the formation of a blood pool on the surface of the stopper and the remaining blood at the needle tip. Thus, there is no risk of nosocomial infection, and the worker can safely perform blood sampling.

  Hereinafter, although this invention is demonstrated using drawing, this invention is not limited to these description.

  FIG. 1 shows an embodiment of the reduced-pressure blood collection tube of the present invention. The decompression blood collection tube of the present invention includes a container body 1 having an opening 11 at the upper end and a lid member 2 attached to the opening 11 of the container body 1.

  The container main body 1 is a bottomed container of a commercially available vacuum blood collection tube having an opening 11 at the upper end. Examples of the material used for the container body include polyethylene terephthalate, polypropylene, and polyethylene naphthalate. Among these, polyethylene terephthalate is preferable from the viewpoint of easy production and excellent transparency, but the present invention is not limited thereto. Moreover, the internal volume of a container main body can be suitably set according to the use of a market. For example, a size of 0.5 to 9.5 ml is practiced.

  Further, a blood anticoagulant or a blood coagulation promoter may be added to the inside of the container body 1. Examples of blood anticoagulants include heparin powder and EDTA-2K. Examples of the blood coagulation promoter include silica sand, crystalline silica, diatomaceous earth, glass fine powder, bentonite, protamine sulfate, and thrombin.

  The lid member 2 is a member that keeps the decompressed state inside the container body by being attached and sealed to the opening of the container body. The lid member 2 includes a plug body 21 that seals the opening 11 of the container body 1 and includes an elastic member at least in the center, and a barrier member 22 that is disposed above the plug body 21.

  The plug body 21 is provided with an elastic member that can be pierced by a needle at the center, and seals the opening 11 of the container body 1 and keeps the decompressed state inside the container body 11. The plug body 21 is not particularly limited as long as it has an elastic member at least in the center and is kept in a reduced pressure state in the container body 1. For example, a general rubber stopper in which all members disclosed in Patent Documents 1 to 4 are formed of elastic members, and a central portion disclosed in Patent Document 5 are formed of elastic members. Film seal type. Since the central portion of the plug body 21 is an elastic member, the blood adhering to the side wall of the needle can be wiped when the needle inserted through the plug body 21 is pulled out. However, a small amount (about 0.3 to 1 μl) of blood adhering to the needle tip leaks to the surface of the stopper 21 and forms a blood pool.

  The elastic member is not particularly limited as long as it is a rubber or elastomer having a restoring force capable of wiping blood adhering to the side wall of the needle when the needle pierced through the elastic member is pulled out. . Specifically, the same member as a rubber plug of a commercially available vacuum blood collection tube may be used, for example, natural rubber, isoprene rubber, chloroprene rubber, silicon rubber, butadiene rubber, styrene-butadiene-styrene block copolymer elastomer, etc. Is mentioned. Among these materials, butadiene rubber is preferable from the viewpoint of material cost.

  Moreover, it is preferable that the thickness of the elastic member at the center of the stopper 21 can keep the inside of the container body 1 airtight and has low piercing resistance. In other words, it is preferably smaller than the thickness (3 to 6 mm) of the central portion of the rubber plug in Patent Documents 1 to 4, for example, about 0.5 to 2 mm, preferably 0.8 to 1.5 mm. However, the present invention is not limited to these. Here, the “center portion” is a region within 1 mm from the center in the cross section perpendicular to the normal direction of the plug body 21 or a barrier member 22 described later, or a blood collection tube when a blood collection tube holder is attached to a decompression blood collection tube. This is a region where the needle provided in the holder penetrates the plug 21 of the vacuum blood collection tube or the barrier member 22 described later.

  The barrier member 22 is a member that can be pierced by a needle and that prevents leakage of a blood pool formed on the top surface of the stopper 21 to the outside. The material of the barrier member 22 is, for example, the same material as that of the plug body 21, that is, rubber such as natural rubber, isoprene rubber, chloroprene rubber, silicon rubber, butadiene rubber, styrene-butadiene-styrene block copolymer elastomer, etc. Examples thereof include film materials such as polyethylene films, polyvinyl acetate films, polyvinyl chloride films, ethylene-ethyl acetate copolymer films, and ethylene-tetrafluoroethylene copolymer films. Furthermore, plastics such as polypropylene, polycarbonate, polytetrafluoroethylene, polyacrylamide, and polyethylene terephthalate may be used. In addition, the film seal type disclosed in Patent Document 5 may be used.

  Among the materials listed above, it is preferable that the material does not crack at the time of piercing, and has a piercing resistance that makes it easy to protrude the needle of the blood collection tube holder from the covering of the rubber material. Therefore, rubber materials such as natural rubber, isoprene rubber, chloroprene rubber, silicon rubber, butadiene rubber, and styrene-butadiene-styrene block copolymer elastomer are preferable. Further, butadiene rubber is preferable from the viewpoint of the cost of the material, but the present invention is not limited to these materials.

  The thickness of the barrier member 22 is appropriately set depending on the selected material, and is not particularly limited. For example, when a rubber material such as natural rubber, isoprene rubber, chloroprene rubber, silicon rubber, butadiene rubber, styrene-butadiene-styrene block copolymer elastomer is selected as the material of the barrier member 22, it is about 0.5 to 6 mm. , Preferably 2 to 4 mm. For example, when a film material such as a polyethylene film, a polyvinyl acetate film, a polyvinyl chloride film, an ethylene-ethyl acetate copolymer film, and an ethylene-tetrafluoroethylene copolymer film is selected as the material of the barrier member 22, It is about 25-300 micrometers, Preferably it is 50-200 micrometers. Furthermore, when using plastics, such as a polypropylene, a polycarbonate, a polytetrafluoroethylene, a polyacrylamide, and a polyethylene terephthalate, as a material of the barrier member 22, it is about 500 micrometers-3 mm, Preferably it is 750 micrometers-2 mm.

  The plug body 21 and the barrier member 22 described above are preferably held by the holding means 3. The holding means 3 is a member that forms the lid member 2 and that holds the plug body 21 and the barrier member 22. By providing the lid member 2 with the holding means 3, blood is not scattered even if the lid member 2 is detached from the container body 1 after blood collection. Moreover, the material which comprises the holding means 3 will not be specifically limited if it can be used for the overcap type of what is called a commercial decompression blood collection tube. Examples thereof include plastics such as polypropylene, polycarbonate, polytetrafluoroethylene, polyacrylamide, and polyethylene terephthalate. Among these materials, polypropylene is preferable from the viewpoint of easy molding and low manufacturing costs. The method of holding the plug body 21 and the barrier member 22 by the holding means 3 may be in accordance with a method for manufacturing a commercially available overcap type lid member 2, and is not particularly limited. This is achieved by welding by means of, and holding by the holding means 3. It is preferable to hold | maintain by joining with an adhesive agent from a viewpoint which can hold | maintain especially firmly.

  The decompression blood collection tube of the present invention is characterized in that at least the central portion of the top surface of the plug 21 is separated from the central portion of the lower surface of the barrier member 22. In other words, at least a region within 1 mm from the center of the top surface of the plug body 21 in a cross section perpendicular to the normal direction does not contact the lower surface of the barrier member 22. The distance is not particularly limited as long as it is at least 1 mm or more, but it is about 1 to 5 mm, preferably about 1 to 3 mm apart, considering that the piercing is accurately performed in the normal direction. Just do it. This prevents the blood pool formed on the top surface of the plug body 21 from leaking outside. In the present invention, a space formed by at least the center portion of the top surface of the plug body 21 being separated from the center portion of the lower surface of the barrier member 22 is referred to as a space portion 4. At least the center of the top surface of the plug body 21 is separated from the center of the lower surface of the barrier member 22, and in the operation of pulling out the needle that has penetrated the plug body 21, the reaction when the needle tip reaches the space portion 4, A small amount of blood adhering to the needle tip is shaken off on the surface of the stopper 21, and blood no longer leaks to the surface of the barrier member 22.

  In order to make at least the central portion of the top surface of the plug body 21 to be separated from the central portion of the lower surface of the barrier member 22, a concave recess 211 is provided in the central portion of the top surface of the plug body 21, as shown in FIG. The disk-like barrier member 22 may be arranged on the upper side, but the embodiment is not limited to this.

  For example, conversely to FIG. 1, even if the top surface of the plug body 21 is flat as shown in FIG. 2, at least the plug body of the barrier member 22 by the annular leg portion 221 extending downward from the barrier member 22. The center portion of the top surface of 21 can be separated from the center portion of the lower surface of the barrier member 22.

  As another modification, for example, as shown in FIG. 3, the stopper 21 and the barrier member 22 are held by the holding means 3 so that at least the center of the top surface of the stopper 21 is separated from the center of the lower surface of the barrier member 22. The form to hold | maintain is also mentioned.

  Preferably, as shown in FIG. 4, if the cover member 2 in FIG. 1 is provided with the holding means 3, the barrier member 22 is firmly fixed, so that a moderate piercing resistance can be applied to the barrier member 22. Due to the piercing resistance, the needle of the blood collection tube holder can easily protrude from the coating of the rubber material, so that the piercing to the barrier member 22 can be performed stably.

  Further, as another modified example of the present invention, a mode in which a spacer is provided so as to separate the plug body 21 and the barrier member 22 as shown in FIGS. The spacer refers to an auxiliary member that acts to separate at least the center of the top surface of the plug body 21 from the center of the bottom surface of the barrier member 22. Examples thereof include an O-ring 51 as shown in FIG. 5 and an annular rib 52 provided on the inner wall of the holding means 3 as shown in FIG. Further, the spacer is not limited to the O-ring 51 and the annular rib 52 as long as it does not affect the piercing with the needle, and a porous absorbent article such as sponge or cotton may be selected.

  When the material of the barrier member 22 and the holding means 3 is the same, that is, when plastics such as polypropylene, polycarbonate, polytetrafluoroethylene, polyacrylamide, and polyethylene terephthalate are selected, the barrier as shown in FIG. If the member 22 and the holding means 3 are integrally formed, the manufacturing cost can be suppressed.

  FIG. 8 is a more preferred modification of FIG. 7 and is a top view of a vacuum blood collection tube. Since the above-described plastic is a relatively hard material, it may be difficult to pierce. Here, as shown in FIG. 8, piercing is facilitated by providing the fragile portion 222 that can be pierced at the piercing location (the center portion of the top surface of the barrier member 22).

  The manufacturing method of the decompression blood collection tube of the present invention explained above may use the conventional manufacturing method, for example, the manufacturing method of the commercially available decompression blood collection tube which is indicated by patent documents 1-4. That is, the lid member 2 may be plugged into the container body 1 under a reduced pressure atmosphere.

  Examples of the present invention will be described below, but the present invention is not limited thereto.

Example 1
The vacuum blood collection tube of FIG. 1 includes a container body 1 (inner diameter of about 13 mm) made of polyethylene terephthalate and a lid member 2. The container body 1 contains heparin powder as a blood anticoagulant, and a reduced pressure state is maintained. The opening 11 of the container body 1 is sealed by the lid member 2. A region 4 mm from the center of the top surface of the plug body 21 is provided with a concave recess 211 having a depth of about 6 mm. The thickness of the piercing part (center part) of the plug 21 is about 3 mm. A disc-shaped barrier member 22 is disposed on the top of the plug body 21. The thickness of the barrier member 22 is about 2 mm. Here, the top surface other than the concave depression 211 of the plug body 21 and the lower surface of the barrier member 22 are in contact with each other by an acrylic adhesive. Thus, a cylindrical space 4 having an outer diameter of about 8 mm and a height of about 6 mm is formed by the recess 211 of the plug body 21 and the lower surface of the barrier member 22.

Example 2
The vacuum blood collection tube in FIG. 2 includes a container body 1 (inner diameter of about 13 mm) made of polyethylene terephthalate and a lid member 2. The container body 1 contains heparin powder as a blood anticoagulant, and a reduced pressure state is maintained. The opening 11 of the container body 1 is sealed by the lid member 2. The top surface of the plug body 21 is a flat surface, and the thickness of the piercing portion (center portion) of the plug body 21 is about 3 mm. A barrier member 22 is disposed on the top of the plug body 21. A region 4 mm from the center of the lower surface of the barrier member 22 includes an annular leg 222 by forming a recess that is concave above a height of about 6 mm. The thickness of the piercing portion (center portion) of the barrier member 22 is about 2 mm. Here, the portion where the top surface of the plug body 21 and the wall surface and the bottom surface of the leg portion 222 of the barrier member 22 are in contact with each other is joined by an acrylic adhesive. Thus, a columnar space 4 having an outer diameter of about 8 mm and a height of about 6 mm is formed by the top surface of the plug body 21, the wall surface of the leg portion 222 of the barrier member 22, and the lower surface of the barrier member 22.

Example 3
The vacuum blood collection tube of FIG. 3 includes a container body 1 (inner diameter of about 13 mm) made of polyethylene terephthalate and a lid member 2. The container body 1 contains heparin powder as a blood anticoagulant, and a reduced pressure state is maintained. The opening 11 of the container body 1 is sealed by the lid member 2. The top surface of the plug body 21 is a flat surface, and the thickness of the piercing portion (center portion) is about 3 mm. A disc-shaped barrier member 22 is disposed on the top of the plug body 21. The thickness of the barrier member 22 is about 2 mm. The plug body 21 and the barrier member 22 are held by a polypropylene holding means 3 (inner diameter of about 17 mm). The holding is performed in a state in which the distance between the top surface of the plug body 21 and the lower surface of the barrier member 22 is about 1 mm, and the side wall of the plug body 21 and the inner wall of the holding means 3 are in contact with each other. 3 This is achieved by joining the portions in contact with the inner wall with an acrylic adhesive. Thus, a columnar space 4 having an outer diameter of about 17 mm and a height of about 1 mm is formed by the top surface of the plug body 21, the lower surface of the barrier member 22, and the inner wall of the holding means 3.

Example 4
The vacuum blood collection tube of FIG. 4 includes a container body 1 (inner diameter of about 13 mm) made of polyethylene terephthalate and a lid member 2. The container body 1 contains heparin powder as a blood anticoagulant, and a reduced pressure state is maintained. The opening 11 of the container body 1 is sealed by the lid member 2. A region 4 mm from the center of the top surface of the plug body 21 is provided with a recess 211 having a depth of about 6 mm. The thickness of the piercing portion (center portion) of the plug body 21 is about 3 mm. A disc-shaped barrier member 22 is disposed on the top of the plug body 21. The thickness of the barrier member 22 is about 2 mm. The plug body 21 and the barrier member 22 are held by a polypropylene holding means 3 (inner diameter of about 17 mm). The holding is achieved by joining a portion where the side wall of the stopper 21 and the inner wall of the holding means 3 are in contact with each other and a portion where the side wall of the barrier member 2 and the inner wall of the holding means 3 are contacted with an acrylic adhesive. Thus, a cylindrical space 4 having an outer diameter of about 8 mm and a height of about 6 mm is formed by the recess 211 of the plug body 21 and the lower surface of the barrier member 22.

Example 5
The vacuum blood collection tube of FIG. 5 includes a container body 1 (inner diameter of about 13 mm) made of polyethylene terephthalate and a lid member 2. The container body 1 contains heparin powder as a blood anticoagulant, and a reduced pressure state is maintained. The opening 11 of the container body 1 is sealed by the lid member 2. The top surface of the plug body 21 is a flat surface, and the thickness of the piercing portion (center portion) is about 3 mm. A disc-shaped barrier member 22 is disposed above the plug body 21 with an O-ring 51 having a height of about 2 mm and a hollow outer diameter of about 11 mm interposed therebetween. Moreover, the thickness of the barrier member 22 is about 2 mm. The plug body 21, the O-ring 51 and the barrier member 22 are held by the holding means 3 made of polypropylene. The holding is achieved by joining the part where the side wall of the stopper 21 and the inner wall of the holding means 3 are in contact with each other and the part where the side wall of the barrier member 2 and the inner wall of the holding means 3 are in contact with each other with an acrylic adhesive. Thus, a cylindrical space 4 having an outer diameter of about 11 mm and a height of about 2 mm is formed by the top surface of the plug body 21, the lower surface of the barrier member 22, and the inner wall of the O-ring 51 cavity.

Example 6
The vacuum blood collection tube in FIG. 6 includes a container body 1 (inner diameter of about 13 mm) made of polyethylene terephthalate and a lid member 2. The container body 1 contains heparin powder as a blood anticoagulant, and a reduced pressure state is maintained. The opening 11 of the container body 1 is sealed by the lid member 2. The top surface of the plug body 21 is a flat surface, and the thickness of the piercing portion (center portion) is about 3 mm. A disc-shaped barrier member 22 is disposed on the top of the plug body 21. The thickness of the barrier member 22 is about 2 mm. The plug body 21 and the barrier member 22 are held by the holding means 3 made of polypropylene. An annular rib 52 having a height of about 2 mm and a thickness of about 2 mm is provided on the inner wall of the holding means 3 so that the distance between the top surface of the rubber plug 21 and the bottom surface of the barrier member 22 is about 2 mm. Retained. The holding is achieved by joining the part where the side wall of the stopper 21 and the inner wall of the holding means 3 are in contact with each other and the part where the side wall of the barrier member 2 and the inner wall of the holding means 3 are in contact with each other with an acrylic adhesive. Thus, a cylindrical space 4 having an outer diameter of about 11 mm and a height of about 2 mm is formed by the top surface of the plug body 21, the lower surface of the barrier member 22, and the inner wall of the annular rib 52 of the holding means 3. .

  According to the reduced pressure blood collection tube of the present invention, when the needle of the blood collection tube holder is pulled out after blood collection, it is possible to prevent the formation of a blood pool on the surface of the stopper and the remaining blood at the needle tip. Thus, there is no risk of nosocomial infection, and the worker can safely perform blood sampling.

It is a figure which shows the Example of the vacuum blood collection tube of this invention. It is a figure which shows the modification of the decompression blood collection tube of this invention. It is a figure which shows the other modification different from FIG. 2 of the decompression blood-collecting tube of this invention. It is a figure which shows the other modified example different from FIG. 2 and 3 of the vacuum blood collection tube of this invention. It is a figure which shows the other modification different from FIGS. 2-4 of the decompression blood-collecting tube of this invention. It is a figure which shows the other modification different from FIGS. 2-5 of the decompression blood-collecting tube of this invention. It is a figure which shows the other modification different from FIGS. 2-5 of the decompression blood-collecting tube of this invention. It is a top view of the decompression blood collection tube in FIG.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Container main body 11 Opening 2 Lid member 21 Plug body 211 Concave hollow 22 Barrier member 221 Leg part 222 Fragile part 3 Holding means 4 Space part 51 O-ring 52 Annular rib

Claims (2)

A vacuum blood collection tube for collecting a blood sample,
A container body having an opening at the upper end, and a lid member attached to the opening,
The lid member includes a plug body that seals the opening and includes an elastic member at least in a central portion, and a barrier member that is provided in an upper portion of the plug body. It is spaced apart from the center of the lower surface of the barrier member ,
The plug is made of natural rubber, isoprene rubber, chloroprene rubber, silicon rubber, butadiene rubber or styrene-butadiene-styrene block copolymer elastomer,
The reduced pressure blood collection tube, wherein the barrier member is made of the same material as the plug . The reduced-pressure blood collection tube according to claim 1, wherein the lid member further includes holding means for holding the stopper and the barrier member.

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