JP4787647B2 - Drug co-infusion device for medical containers - Google Patents

Description

  The present invention relates to a medicine co-infusion apparatus for medical containers using a prefilled syringe.

Prior to administering the infusion to the patient, various drugs such as vitamins, minerals, and antibiotics are required for the medicinal solution (infusion) filled in the medical container (specifically, the infusion container). It is performed according to. Such a medicine is blended by sucking a drug solution from a vial with a syringe and then injecting (mixing) the drug solution into an infusion container. However, the formulation of such a drug has a drawback that the operation is complicated and it takes a long time for the formulation and the administration. Thus, it has been proposed to employ a so-called prefilled syringe that is pre-filled with a chemical solution.
As a medicine filled in such a prefilled syringe for compounding, there is a medicine that should not be directly administered to a blood vessel (vein) without being diluted. Such a medicine must be a medical container ( It is administered after infusion / dilution in an infusion container. When working with prefilled syringes filled with such drugs, healthcare professionals use them with great care.
In addition, prefilled syringes filled with such drugs are designed to be distinguishable from prefilled syringes filled with other drugs at first glance, so that the filled drugs are not directly administered to the blood vessels without being diluted. Ingenuity has been devised.
The applicant has not found any related prior art.

Even if you pay enough attention or arouse attention, there are also factors such as urgency, and dilution of the drug filled into the side tube of the infusion circuit directly connected to the blood vessel or the three-way stopcock etc. There is no possibility of misadministration without being done at all.
Therefore, an object of the present invention is to provide administration by direct puncture to a living body, connection to a port of a side tube / three-way stopcock provided in the middle of an infusion circuit, and needleless provided in the middle of an infusion circuit Disclosed is a medicine co-infusion device for a medical container in which administration at a connecting portion is impossible and the possibility of administration without being mixed into an infusion container is extremely low.
Moreover, the protector which protects a normal needle part is mounted | worn with the chemical | medical agent mixed needle. The mixed injection needle has a plurality of outer surface ribs provided on the outer surface of the mixed injection needle, and the protector is provided on the inner surface of the protector and can be in contact with the outer surface rib of the mixed injection needle. There is something with. By rotating the protector, the outer surface rib and the inner surface rib of the mixed injection needle come into contact with each other, whereby the mixed injection needle is attached to the nozzle portion of the outer cylinder. Then, when the protector is attached, or when the co-infusion needle is loosened during operation, it may be necessary to reattach the protector once removed. However, since the inner rib of the protector and the outer rib of the co-injection needle cannot be confirmed when both of them are mounted, they often come into contact with each other during the operation, and the mounting operation is not always easy.
Then, the 2nd objective of this invention is providing the chemical | medical agent co-infusion apparatus to the medical container which can mount | wear with the protector to the co-injection needle very easily.
In addition, as described above, a protector that protects the normal needle portion is attached to the medicine mixed injection needle. The mixed injection needle has a plurality of outer surface ribs provided on the outer surface of the mixed injection needle, and the protector is provided on the inner surface of the protector and can be in contact with the outer surface rib of the mixed injection needle. There is something with. By rotating the protector, the outer surface rib and the inner surface rib of the mixed injection needle are brought into contact with each other, and the mixed injection needle is mounted on the nozzle portion of the outer cylinder by utilizing the rotational torque applied to the inner surface rib.
The hat for co-infusion during the operation is hated to loosen, and the co-injection needle may be excessively fastened to the nozzle portion of the outer cylinder by applying excessive torque via the protector. At the time of disposal or when the mixed injection needle is replaced, it may be necessary to remove the mixed injection needle from the outer cylinder. However, it is often difficult to remove the co-infusion needle easily when rotating with the co-injection needle held, so it is necessary to reattach the protector, and even if the protector is reattached, it may be difficult to remove it. .
Accordingly, a third object of the present invention is to provide a medicine co-infusion device for a medical container in which a co-injection needle is not excessively fastened to the nozzle portion of the outer cylinder.

The following objects are achieved.
(1) an outer cylinder main body, an outer cylinder provided with a nozzle portion provided at a distal end portion of the outer cylinder main body portion and having an open front end, a sealing member for sealing the nozzle portion, and a slide inside the outer cylinder. A gasket housed in a movable manner, a pusher attached to or attachable to the rear end of the gasket, a prefilled syringe comprising a medicine filled in the outer cylinder, and the seal member after the release A drug co-injection device for a medical container comprising a co-injection needle that can be attached to a nozzle part and can be pierced into a co-infusion port of a medical container containing a medical solution, wherein the nozzle part of the outer cylinder is the outer cylinder An inner cylinder projecting outward from the front end surface of the main body, an outer cylinder provided to enclose the inner cylinder, and an engagement outer rib provided on the outer surface of the outer cylinder And the difference between the outer diameter of the tip of the inner cylinder and the inner diameter of the tip of the outer cylinder is A .5Mm～1.5Mm, the inner diameter of the distal portion of the outer cylinder part is in 2~3mm or 6 to 10 mm, a normal medical female connection portion is unreachable form standard with 6% taper Further, the mixed injection needle is provided at a needle main body portion and a proximal end portion of the needle main body portion, and forms an intrusion and liquid-tight state between the outer cylinder portion and the inner cylinder portion of the nozzle portion. A middle tube portion that can be encased, a tubular portion that encloses the middle tube portion, and has an inner rib for engagement that can be engaged with or screwed with the outer rib for engagement of the nozzle portion on the inner surface, and the needle body parts and the puncture needle portion provided at a front end portion of the located 10~25mm proximal side of the distal end of the mixed injection needle, and a side hole communicating with the mixed injection needle inside and the outside, for the mixed injection Only when the needle is punctured into the mixed injection port of the medical container at least to the side hole position. Injection needle inside said through medical container interior and is communicating, that Do is possible to inject the drug agent mixture delivery instrument into the medical container.

Moreover, what achieves the said objective is as follows.
(2) an outer cylinder main body, an outer cylinder provided with a nozzle portion provided at the distal end of the outer cylinder main body and having an opening at the distal end; a gasket slidably accommodated in the outer cylinder; A medical device comprising a prefilled syringe comprising a pusher attached to or attachable to the rear end, and a mixed injection needle that can be attached to the nozzle part and can be punctured into a mixed injection port of a medical container containing a chemical solution. A medicine co-injection device for a container, wherein the nozzle part of the outer cylinder is provided so as to enclose the inner cylinder part and an inner cylinder part protruding outward from the distal end surface of the outer cylinder main body part. An outer cylinder part and an outer rib for engagement provided on the outer surface of the outer cylinder part are provided, and the difference between the outer diameter of the tip part of the inner cylinder part and the inner diameter of the tip part of the outer cylinder part is 0. a 5Mm～1.5Mm, the inner diameter of the distal portion of the outer cylindrical section, 2 to 3 mm or 6.0 In 0 mm, it has a normal medical female connection portion is unreachable form standard with 6% taper, further the mixed injection needle is provided a needle body portion, the proximal end of the needle main body portion An intermediate cylinder part that can penetrate between the outer cylinder part and the inner cylinder part of the nozzle part and can form a liquid-tight state; encloses the intermediate cylinder part; A cylindrical portion having an inner rib that can be engaged with or screwed with an outer rib, a puncture needle portion provided at the distal end portion of the needle body portion, and a position 10 to 25 mm proximal from the distal end of the mixed injection needle and, a side hole communicating with the mixed injection needle inside and the outside, the needle internal for the mixed injection only when the mixed injection needle is punctured into the mixture injection port of the medical container at least to the lateral hole position communication and internal medical container, that Do is possible to inject the drug agent to a medical container Note instrument.

(3) The medicine co-infusion apparatus according to (1) or (2), wherein the engagement outer rib is a spiral rib.
(4) The medicine co-injection device according to any one of (1) to (3), wherein the engagement inner rib is the plurality of discontinuous short ribs.
(5) The medicine co-injection device according to any one of (1) to (4), wherein the inner cylinder portion of the nozzle portion has no taper or a cylindrical shape having a taper of 5.5% or less .
( 6 ) The mixed injection device according to any one of (1) to (5), wherein the mixed injection needle includes a plurality of the side holes.
( 7 ) The needle body portion of the mixed injection needle has a first region having an acute taper angle that forms a puncture end from the distal end side, and has a gentle taper angle or taper angle that is continuous with the first region. A second region that is not continuous, a third region that is continuous with the second region and has a taper angle larger than the taper angle of the second region, and a continuous taper angle or taper angle that is continuous with the third region. (1) thru | or the medicine co-infusion apparatus in any one of ( 6 ) which has a 4th area | region which is not.
( 8 ) The medicine co-infusion device according to ( 7 ), wherein the side hole is provided at a distal end portion of the third region or the fourth region.

( 9 ) The mixed medicine injection device includes a protector attached to the mixed injection needle, the mixed injection needle includes a plurality of outer surface ribs provided on an outer surface of the mixed injection needle, and the protector includes the protector, A plurality of inner surface ribs provided on the inner surface of the protector and capable of coming into contact with the outer surface rib of the mixed injection needle, and a marker portion provided on the outer surface of the protector for recognizing a non-arranged portion of the inner surface rib. (1) thru | or the medicine co-infusion apparatus in any one of ( 8 ).

  According to the medicine co-injection device for the medical container of the present invention, since the injection needle cannot be connected to the outer cylinder, it is impossible to puncture the living body and is provided in the middle of the infusion circuit. Since it cannot be connected to the side tube / three-way stopcock port, and also to the needleless connection part provided in the middle of the infusion circuit, the drug in the syringe can be administered without being diluted. In addition, the filled medicine is safe because it is used for the mixed injection operation to the infusion solution in the infusion container using the dedicated mixed injection needle.

A medicine co-infusion apparatus for a medical container of the present invention will be described with reference to an embodiment shown in the drawings.
FIG. 1 is an external view of a medicine mixed injection device of the present invention. FIG. 2 is an external view of the medicine co-infusion apparatus of the present invention in a state where co-infusion is possible. FIG. 3 is a front view of an outer cylinder of a prefilled syringe used in the medicine co-infusion apparatus of the present invention. FIG. 4 is a cross-sectional view of the outer cylinder of FIG. FIG. 5 is a right side view of the outer cylinder shown in FIG. FIG. 6 is a front view of a co-injection needle used in the drug co-infusion apparatus of the present invention. FIG. 7 is an external view of the mixed injection needle of FIG. 6 in a state where the needle is rotated by a predetermined angle. FIG. 8 is a right side view of the mixed injection needle shown in FIG. 6. FIG. 9 is a left side view of the mixed injection needle shown in FIG. 10 is a cross-sectional view taken along line AA in FIG. 11 is a cross-sectional view taken along line BB in FIG. 12 is a cross-sectional view taken along the line CC of FIG.

An explanation will be given by using the drug mixed injection device of the embodiment illustrating the drug mixed injection device to the medical container of the present invention.
The medicine co-injection device 1 includes an outer cylinder main body 21, an outer cylinder 2 including a nozzle portion 22 provided at a distal end portion of the outer cylinder main body portion 21, and a sealing member 4 that seals the nozzle portion 22. The prefilled syringe 10 is composed of a gasket 5 slidably accommodated in the outer cylinder 2, a pusher 6 attached to or attachable to the rear end of the gasket, and a medicine 8 filled in the outer cylinder 2. And a mixed injection port having a pierceable plug body made of rubber or elastomer of a medical container (for example, an infusion container) that can be attached to the nozzle portion 22 after the sealing member 4 is detached. And a co-injection needle 3 that can be punctured.

The plug body incorporated in the co-infusion port usually has an area having a diameter of about 1 to 5 cm as an piercing portion, and the thickness of the area is about 0.5 to 1.5 cm. Therefore, the needle main body 31 of the mixed injection needle 3 to be described later has a length of 0.5 cm or more, preferably 1.5 cm or more, on the proximal side from the side holes 36a, 36b, 36c.
And the nozzle part 22 of the outer cylinder 2 includes an inner cylinder part 23 protruding outward from the front end surface of the outer cylinder main body part 21, an outer cylinder part 24 provided so as to enclose the inner cylinder part 23, The outer rib 25 for engagement provided on the outer surface of the outer cylinder part 24 is provided, and the difference between the outer diameter of the tip part of the inner cylinder part 23 and the inner diameter of the tip part of the outer cylinder part 24 is 0.5 mm to 1.. It is 5 mm, and the inner diameter of the distal end portion of the outer cylinder portion 24 is 2 to 3 mm or 6 to 10 mm, so that a normal medical female connection portion cannot be connected.

As shown in FIGS. 6 to 12, the mixed injection needle 3 is provided at the needle body portion 31 and the proximal end portion of the needle body portion 31, and enters between the outer cylinder portion 24 and the inner cylinder portion 23 of the nozzle portion 22. A cylindrical shape having a middle tube portion 38 capable of forming a liquid-tight state, and an inner rib portion 37a, 37b for engaging the outer rib 25 for engagement of the nozzle portion 22 on the inner surface while enclosing the middle tube portion 38. Part 33, a puncture needle part 32 provided at the distal end of the needle main body 31, and a side which is located 10 to 25 mm proximal to the distal end of the mixed injection needle 3 and communicates with the internal 42 of the mixed injection and the outside Holes 36a, 36b, and 36c are provided.
As shown in FIGS. 6 to 9, the needle body 31 of the mixed injection needle 3 includes a first region 32 having an acute taper angle forming the puncture needle portion 32 from the distal end side, and the first region 32. A second region 52 that is continuous and has a gentle taper angle or substantially no taper angle, and a third region 53 that is continuous with the second region 52 and has a taper angle larger than the taper angle of the second region 52 by a predetermined angle. It is preferable to have a fourth region 54 that is continuous with the third region and has no gentle taper angle or substantially no taper angle.

The taper angle (taper spread angle) of the first region 32 is preferably 0 ° to 90 °, and the length is preferably 2.0 to 5.0 mm. The taper angle (taper divergence angle) of the second region 52 is preferably 0 ° to 10 °, and the length is preferably 5.0 to 20.0 mm. The taper angle (taper spread angle) of the third region 53 is preferably 20 ° to 90 °, the length is preferably 2.0 to 5.0 mm, and the start end of the third region 53 is the mixed injection needle 3. It is preferable that it is 10-25 mm base end side from the front-end | tip. In addition, the taper angle (taper spread angle) of the fourth region 54 is preferably 0 ° to 10 °, and the length is preferably 10 to 20 mm.
And it is preferable that the side hole 36 is provided in the front-end | tip part of a 3rd area | region or a 4th area | region.
As described above, by having the third region 53 having a taper angle larger than that of the front and rear portions in the middle thereof, erroneous puncture to the side tube port and the needleless connection portion provided in the middle of the infusion circuit is surely avoided. be able to. Furthermore, the outer diameter of the fourth region is preferably 3.5 to 7.0 mm, and particularly preferably 4.0 to 5.0 mm. By doing in this way, erroneous puncture prevention becomes more effective while maintaining the piercing property to the mixed injection port.

The medicine mixed injection device 1 includes a prefilled syringe 10 and a mixed injection needle 3.
The prefilled syringe 10 is slidably accommodated in the outer cylinder 2, a sealing member 4 (specifically, a removable cap) that seals the nozzle portion 22 of the outer cylinder 2, and the outer cylinder 2. It comprises a gasket 5, a pusher 6 attached or attachable to the rear end of the gasket, and a medicine 8 filled in the outer cylinder 2.
The outer cylinder 2 is a cylindrical body formed of a transparent or translucent material, if necessary, with a material having low oxygen permeability and water vapor permeability.
The outer cylinder 2 includes an outer cylinder main body portion 21, a nozzle portion 22 provided at the distal end portion of the outer cylinder main body portion 21, and a flange 26 provided at the rear end portion of the outer cylinder main body portion 21.
The outer cylinder main body portion 21 is a substantially cylindrical portion that accommodates the gasket 5 in a liquid-tight and slidable manner, and the nozzle portion 22 is a cylindrical portion having a smaller diameter than the outer cylinder main body portion 21. Further, the distal end portion (shoulder portion) of the outer cylinder main body portion 21 is tapered toward the nozzle portion 22 in a tapered shape.

As shown in FIGS. 3, 4, and 6, the flange 26 is an elliptical donut-shaped disk portion formed so as to protrude in the vertical direction from the entire rear end circumference of the outer cylinder main body portion 21. The flange 26 includes two gripping portions that are wide and facing each other, and a plurality of ribs are formed on the tip surface side of the gripping portion. In addition, the rear end surface of the flange 26 has a concave portion at the peripheral edge and the outer cylinder rear end portion other than the rib portion.
As shown in FIGS. 3, 4, and 13, the nozzle portion 22 is provided so as to enclose the inner cylinder portion 23 and an inner cylinder portion 23 that protrudes outward from the distal end surface of the outer cylinder main body portion 21. The outer cylinder part 24 and the engaging outer rib 25 provided on the outer surface of the outer cylinder part 24 are provided.

The nozzle part 22 does not have a 6% taper, and the space 27 between the outer cylinder part 24 and the inner cylinder part 23 is formed narrow, so that a normal standard female female connection part having a 6% taper ( For example, the needle hub and the three-way stopcock port) cannot be connected. The standard medical female connection is ISO 594-1: 1986, “Matching joints with 6% (approximately 3.43 °) taper of syringe barrels, needles and other medical devices-Part 1 : General requirements ”.
The end of the medical female connection part of the standard (ordinary standard) defined in ISO594-1: 1986 has an inner diameter of 4.270 mm to 4.315 mm and an outer diameter of 6.73 mm at the maximum. And in the medicine mixed injection device 1 of the present invention, the difference between the outer diameter of the distal end portion of the inner cylindrical portion and the inner diameter of the distal end portion of the outer cylindrical portion and the inner diameter of the distal end portion of the outer cylindrical portion are as described above. Therefore, the penetration into the space 27 between the outer cylinder part 24 and the inner cylinder part 23 of the nozzle part 22 of the medicine co-infusion apparatus of the present invention of the medical female connection part of the standard prescribed in the above-mentioned ISO594-1: 1986. To prevent.

Specifically, the inner cylinder portion 23 has a cylindrical shape that does not substantially have a taper. Having substantially no taper is a concept including one having a taper of about 0 to 5.5% (0 to about 3.15 °). Similarly, the outer cylinder portion 24 has a cylindrical shape substantially without a taper. Having substantially no taper is a concept including one having a taper of about 0 to 5.5% (0 to about 3.15 °). The difference between the outer diameter of the inner cylinder part 23 and the inner diameter of the outer cylinder part 24 of the nozzle part 22 is preferably 0.5 to 1.5 mm, and more preferably 0.6 to 1.0 mm. Is preferred. By doing in this way, the penetration | invasion to 27 between the outer cylinder part 24 and the inner cylinder part 23 of a medical female type | mold connection part is prevented. Further, it is preferable that the tip of the inner cylinder part 23 slightly protrudes from the tip of the outer cylinder part 24. The protrusion length is preferably 1.5 mm or less. Further, the axial length of the inner cylinder portion 23 is preferably about 6.5 to 9.0 mm.
And the outer side rib 25 for engagement is provided in the outer surface of the outer cylinder part. In this embodiment, it is a spiral rib. Specifically, it has two spiral shapes.

The nozzle portion 22 of the outer cylinder 2 is sealed with a sealing member. In this embodiment, a removable cap 4 is used as a sealing member. In addition, as a sealing member, the peelable film-like thing which seals the front end surface of the inner cylinder part 23 of the nozzle part 22 may be sufficient.
Examples of the material for forming the outer cylinder 2 include polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly- (4-methylpentene-1), acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate. Various resins such as polyester and cyclic polyolefin can be used, and among them, resins such as polypropylene and cyclic polyolefin are preferable because they are easy to mold and have heat resistance. In addition, as a material for forming the outer cylinder 2, it is preferable to use a resin having a relatively higher hardness than the cap 4 in order to improve sealing performance. If it does in this way, when attaching the cap to a nozzle, a cap will stick to a nozzle with screwing operation, and it can improve sealability more.

As shown in FIG. 1, the gasket 5 includes a main body portion extending with substantially the same outer diameter, and a plurality of annular ribs provided on the main body portion (in this embodiment, two, two or more liquid-tight These ribs are in fluid-tight contact with the inner surface of the outer cylinder 2. Further, the front end surface of the gasket 5 has a shape corresponding to the inner surface of the front end of the outer cylinder 2 so as not to form a gap as much as possible when contacting the inner surface of the front end of the outer cylinder 2.
The material for forming the gasket 5 includes elastic rubber (for example, butyl rubber, latex rubber, silicone rubber, styrene butadiene rubber), synthetic resin (for example, styrene elastomer such as SBS elastomer and SEBS elastomer, ethylene-α olefin copolymer). It is preferable to use an olefin elastomer such as a polymer elastomer).

The gasket 5 is provided with a recess extending inward from the rear end thereof. The recess has a female screw shape, and is a male screw portion formed on the outer surface of the protruding portion formed at the tip of the pusher 6. And can be screwed together. The pusher 6 is not detached from the gasket 5 by screwing them together. The pusher 6 may be removed and attached at the time of use.
As described above, the pusher 6 includes a protruding portion that protrudes in a cylindrical shape at the tip, and a male screw is formed on the outer surface of the protruding portion. The pusher 6 includes a main body portion extending in the axial direction having a cross-shaped cross section, a pressing disk portion provided at the rear end portion, and a rib provided in the middle of the main body portion.
The drugs 8 filled in the outer cylinder include nitroglycerin, cyclosporine, benzodiazepine drugs, high-concentration sodium chloride injection, vitamins, minerals, antibiotics and other chemicals, vitamins (general vitamins), various amino acids Antithrombotic agents such as heparin, insulin, antitumor agents, analgesics, cardiotonic agents, intravenous anesthetics, antiparkinsonian agents, ulcer treatment agents, corticosteroid agents, arrhythmic agents, correction electrolytes, antiviral agents, Any substance such as an immunostimulant may be used, but it is particularly effective when it is a drug that may cause serious health damage when rapidly administered into a vein.

Next, the mixed injection needle 3 will be described.
FIG. 6 is a front view of a co-injection needle used in the drug co-infusion apparatus of the present invention. FIG. 7 is an external view of the mixed injection needle of FIG. 6 in a state where the needle is rotated by a predetermined angle. FIG. 8 is a right side view of the mixed injection needle shown in FIG. 6. FIG. 9 is a left side view of the mixed injection needle shown in FIG. 10 is a cross-sectional view taken along line AA in FIG. 11 is a cross-sectional view taken along line BB in FIG. 12 is a cross-sectional view taken along the line CC of FIG. FIG. 13 is an explanatory diagram for explaining a state in which a mixed injection needle is attached to the nozzle portion of the outer cylinder.
As shown in FIG. 2, the mixed injection needle 3 can be liquid-tightly attached to the nozzle portion 22 of the outer cylinder 2. As shown in FIGS. 6 to 12 and 18, the mixed injection needle 3 is provided at the proximal end of the hollow needle main body 31 with the distal end closed and the nozzle main body 31. The middle cylinder part 38 that can penetrate between the cylinder part 24 and the inner cylinder part 23 and form a liquid-tight state, encloses the middle cylinder part 38, and engages the outer rib 25 for engagement of the nozzle part 22 on the inner surface. A cylindrical portion 33 having engagement inner ribs 37 a and 37 b and a puncture needle portion 32 provided at the distal end portion of the needle main body portion 31 are provided.

The mixed injection needle 3 is provided at a position 10 to 25 mm proximal from the distal end, and includes side holes 36a, 36b, and 36c that allow the mixed injection needle interior 42 to communicate with the outside. Furthermore, the mixed injection needle 3 includes groove portions 35a, 35b, and 35c that are provided on the side surface and communicate with the side holes 36a, 36b, and 36c and extend to the distal end portion of the needle body portion 31.
Therefore, in this mixed injection needle 3, if the mixed injection needle is not a part that can be punctured at least to the side hole position (specifically, a mixed injection port of a medical container), even if punctured, the puncture needle (in other words, Since it does not communicate with the inside of the prefilled syringe), no medicine is injected. For this reason, the tip of the needle hits the internal depth part of the side tube port or the like, and the side hole is assumed to have been able to puncture the side tube port or the so-called needleless system, which may be directly injected into the vein. Since the position does not reach the position where injection is possible, injection of the drug is impossible.

Further, the mixed injection needle hits the side tube port or the rubber partition wall of the closed system by the third region 53 and prevents the side hole near the third region 53 from being punctured to a position where injection is possible. Even a device of a type having a deep internal depth such as a drug cannot be injected.
Specifically, the middle tube portion 38 of the mixed injection needle 3 has a substantially cylindrical shape without a taper. Having substantially no taper is a concept including one having a taper of about 0 to 5.5% (0 to about 3.15 °). Similarly, the cylindrical portion 33 has a substantially cylindrical shape without a taper. Having substantially no taper is a concept including one having a taper of about 0 to 5.5% (0 to about 3.15 °). The middle cylinder portion 38 is formed in a form that can enter the inner cylinder portion 23 of the nozzle portion 22 and be in close contact with the liquid-tight body. Further, the base end of the middle cylinder portion 38 is shorter than the base end of the cylindrical portion 33 by a predetermined distance. The distance between the proximal end of the middle tubular portion 38 and the proximal end of the tubular portion 33 is preferably 2.5 to 3.5 mm.
Further, the tubular portion 33 has engagement inner ribs 37a and 37b that engage with the engagement outer rib 25 of the nozzle portion 22 formed on the inner surface at a position a predetermined distance from the base end. In this embodiment, the engaging inner ribs 37a and 37b are a plurality of short ribs that are provided and are not continuous. Specifically, as shown in FIGS. 9 and 10, the engagement inner ribs 37 a and 37 b are short ribs extending in the inner circumferential direction formed in two opposite positions. Further, the cylindrical portion 33 is provided with window portions 34 a and 34 b so that the outer cylindrical portion of the nozzle portion 22 can be visually recognized when the cylindrical portion 33 is attached to the outer cylinder 2.

The mixed injection needle 3 includes a groove that includes a side hole and extends in the axial direction.
Specifically, as shown in FIGS. 6 to 8, 11, and 12, the co-injection needle 3 has a start end at a position that is a base end side by a predetermined distance from the tip, and a plurality of grooves 35 a extending a predetermined length. , 35b, 35c. In this embodiment, the plurality of grooves 35 a, 35 b, and 35 c are arranged at an equal angle with respect to the central axis of the mixed injection needle 3. In this embodiment, the three grooves are arranged at substantially equal angles. The starting end position of the groove is preferably a position that is about 5 to 20 mm from the tip end to the base end side. Moreover, it is preferable that the terminal of a groove | channel is a side hole formation position. The length of the groove is preferably about 2 to 20 mm. Further, the plurality of side holes 36a, 36b, 36c are located in each groove, and are therefore arranged at an equal angle with respect to the central axis of the mixed injection needle 3. As shown in FIG. 12, a plurality of ribs 43 a, 43 b, 43 c extending in the axial direction are formed on the inner surface of the mixed injection needle 3. This rib extends a predetermined distance from the position between the side holes of the plurality of side holes 36a, 36b, 36c to the proximal end side of the mixed injection needle. By providing such ribs 43a, 43b, and 43c, the external force applied to the side hole portion is dispersed, the physical strength against breakage and the like is improved, and the mixed injection needle 3 is further improved from the side holes 36a, 36b, and 36c. The interference of the liquid flowing into the interior 42 is prevented, and a good liquid flow is formed. The mixed injection needle 3 includes ribs 39 a and 39 b extending from the distal end of the cylindrical portion 33 toward the distal end side. The ribs 39a and 39b can be engaged with a rib 73 formed on the inner surface of the base end portion of the protector 7 to be described later, and the mixed injection needle 3 with the protector attached to the outer cylinder 2 is attached. Easy to put on and take off.

Examples of the material for forming the mixed injection needle 3 include polypropylene, polyethylene, polystyrene, polyamide, polycarbonate, polyvinyl chloride, poly- (4-methylpentene-1), acrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene. Polyester such as terephthalate, cyclic olefin resin, polyether ether ketone, polybutylene terephthalate, polycarbonate, polyamide, polyacetal, modified polyphenylene ether, polyester resin, fluorine resin, polysulfone, polyetherimide, polyethersulfone, polyetherketone , Polyether lactone, thermoplastic resin such as liquid crystal polyester, or epoxy resin, unsaturated polyester resin, phenol resin, urea resin, melamine Resins, such as thermosetting resin of the polyurethane resin.
Furthermore, the mixed injection needle forming material preferably contains reinforcing fibers. The reinforcing fiber is preferably a long fiber, but may be a short fiber. Moreover, although the addition amount of the fiber with respect to the resin material in a forming material changes with combinations of resin and fiber to be used, about 10-80 volume% is preferable based on the whole needle for co-infusion, More preferably, it is 30-80 volume. %, Particularly preferably 40 to 70% by volume.
The reinforcing fibers include carbon fibers, whiskers, glass fibers, graphite fibers, aramid fibers, polyethylene fibers, wholly aromatic polyester fibers, polyimide fibers, polamideimide fibers, heterocyclic high-performance fibers, polyamide fibers, Polyarylate fibers and the like are suitable.

As shown in FIGS. 1 and 18, a protector 7 is attached to the mixed injection needle 3.
As shown in FIGS. 1 and 18, the protector 7 encloses the mixed injection needle 3 to prevent the puncture needle portion from being exposed, and to attach and detach the mixed injection needle 3 from the nozzle portion of the outer cylinder 2. Is to assist.
FIG. 14: is a front view of the protector for mixed injection needles used for the chemical injection device of this invention. 15 is a cross-sectional view taken along the line DD of FIG. 16 is a right side view of the mixed needle protector of FIG. FIG. 17 is a left side view of the mixed needle protector of FIG. FIG. 18 is a cross-sectional view of a mixed injection needle with a mixed injection needle protector attached thereto.
As shown in FIGS. 14 to 18, the protector is located on the proximal end side of the cylindrical main body portion 70 that can accommodate the needle main body portion 31 including the puncture needle portion 32 of the mixed injection needle 3, and It is a cylindrical body having an enlarged diameter portion 72 that accommodates the formation site of the ribs 39a and 39b. And the front-end | tip part of the main-body part 70 is a closed end, and also on the outer surface of the main-body part 70, as shown in FIG.14 and FIG.16, several rib 71a, 71b, 71c, which extends in an axial direction. 71d, 71e, 71f are provided. This rib functions as a slip stopper when the protector is rotated. Further, as shown in FIGS. 15 and 17, ribs 39 a and 39 b that extend from the distal end of the cylindrical portion 33 of the mixed injection needle 3 to the distal end side when the protector 7 is rotated are provided on the inner surface of the enlarged diameter portion 72. And a plurality of ribs 73 to be engaged. By engaging both ribs, the rotation applied to the protector 7 is transmitted to the mixed injection needle 3, and the mixed injection needle 3 also rotates. For this reason, the mixed injection needle 3 can be attached to the nozzle portion of the outer cylinder while the protector 7 is attached. In this embodiment, four ribs 73 are provided so as to be substantially equiangular with respect to the central axis of the protector.
In the above description, the sealing member that seals the nozzle portion and the medicine mixed injection device of the embodiment in which the medicine is stored in the outer cylinder have been described. However, as the medicine mixed injection device, a tool that does not include them. It may be a medicine co-infusion device.

  Moreover, the medicine mixed injection device of all the embodiments described above includes a protector 7 attached to the mixed injection needle 3, and the mixed injection needle 3 includes a plurality of outer surface ribs 39 a and 39 b provided on the outer surface of the mixed injection needle 3. The protector 7 is provided on the inner surface of the protector 7 and has a plurality of inner surface ribs 73 that can come into contact with the outer surface ribs 39a and 39b of the mixed injection needle 3, and the protector 7 It may be provided on the outer surface and provided with marker portions 74a and 74b for recognizing the non-arranged portion of the inner surface rib 73.

Next, a drug mixed injection device according to another embodiment of the present invention will be described.
The drug mixed injection device of this embodiment has substantially the same configuration as the above-described drug mixed injection device 1. As shown in FIG. 19, the only difference is that marker portions 74 a and 74 b are provided on the outer surface of the protector 7 to recognize the non-arranged portions of the inner surface rib 73. 19 and 20 are explanatory diagrams for explaining a protector used in a medicine mixed injection device according to another embodiment of the present invention.
As shown in FIGS. 1 to 18 and described above, the medicine co-infusion device includes an outer cylinder main body 21 and an outer nozzle section 22 provided at the distal end of the outer cylinder main body 21 and having an open front end. A cylinder 2, a sealing member 4 for sealing the nozzle portion 22, a gasket 5 slidably accommodated in the outer cylinder 2, and a pusher 6 attached to or attachable to the rear end of the gasket, A prefilled syringe 10 composed of a medicine 8 filled in the outer cylinder 2, a mixed injection needle 3 that can be attached to the nozzle portion 22 of the outer cylinder 2 and can be punctured into a mixed injection port of a medical container containing a chemical solution, and mixed injection And a protector 7 attached to the needle 3.

In this medicine mixed injection device, the nozzle portion 22 of the outer cylinder 2 includes an engagement rib 25 provided on the outer surface of the nozzle portion 22, and the mixed injection needle 3 engages with the engagement rib 25 of the nozzle portion 22. Alternatively, the inner ribs 37a and 37b that can be screwed together and a plurality of outer surface ribs 39a and 39b provided on the outer surface of the mixed injection needle are provided. The protector 7 is provided on the inner surface of the protector 7, and is provided on the outer surface of the protector 7 with a plurality of inner surface ribs 73 that can come into contact with the outer surface ribs 39 a and 39 b of the mixed injection needle 3. Marking parts 74a and 74b for recognizing the arrangement part are provided.
The outer cylinder 2 and the mixed injection needle 3 are the same as those described above, and the above description should be referred to.
And in this chemical | medical agent mixed injection instrument, as shown in FIG. 19, it is provided in the outer surface of the protector 7, and is equipped with the marker parts 74a and 74b for making the non-arrangement | positioning part of the inner surface rib 73 recognized. As shown in FIG. 19, the inner ribs are not arranged in the marker portions 74 a and 74 b.

In the embodiment shown in FIG. 19, the protector 7 has a plurality of outer surface ribs 71 provided on the outer surface and extending in the axial direction, and the marker portion 74 is a rib having a rib interval wider than other rib intervals. It is comprised by the separation part.
Specifically, as shown in FIG. 19, the protector 7 includes a plurality of (specifically, six) ribs 71a to 71f extending in the axial direction. The outer ribs are divided into a first group including ribs 71a, 71b, and 71c and a second group including ribs 71d, 71e, and 71f. The rib interval in each group is substantially the same. However, it is widely formed between the groups, and rib spacing portions 74a and 74b facing each other are formed. In particular, in the case shown in FIG. 19, ribs are formed at the apexes of a regular polygon (specifically, regular octagons), and ribs are not formed only at a pair of apexes facing each other. It is in the form provided. And the inner surface of the protector of the area | region used as the rib separation part 74a, 74b is a rib non-formation part. For this reason, a rib non-formation part can be recognized by recognizing a rib separation part. Therefore, when the protector is attached to the mixed injection needle 3, the outer rib 73 and the inner rib 71 are brought into contact with each other by inserting the outer rib 73 of the mixed injection needle 3 so as to be in the region of the marker portions 74a and 74b. A protector can be attached to the mixed injection needle 3 without contact.

Moreover, the form of the labeling part is not limited to the above. For example, as shown in FIG. 20, the protector 7 a may include an outer surface rib 71 provided on the outer surface and extending in the axial direction, and the marker portion may be configured by the rib 71.
Specifically, in the protector 7a shown in FIG. 20, ribs 71b and 71e are provided so as to face the outer surfaces of the facing portions that are the inner rib non-forming portions. In this case, contrary to the above-described embodiment, the ribs 71b and 71e constitute a sign portion.
Furthermore, as the marking part, the protector has a surface area having a surface state different from that of the other part partially formed on the outer surface, and the marking part is configured by a surface area having a surface condition different from that of the other part. It may be a thing.
For example, it is conceivable that surface areas having different surface states are rough areas. As the form of the rough surface, an embossed surface, a small protrusion forming surface, a groove forming surface and the like are preferable. Conversely, the entire outer surface of the protector may be a rough surface, and surface regions having different surface states constituting the marker portion may be formed by a smooth surface.

Moreover, the medicine mixed injection device of all the embodiments described above includes a protector 7 attached to the mixed injection needle 3, and the mixed injection needle 3 includes a plurality of outer surface ribs 39 a and 39 b provided on the outer surface of the mixed injection needle 3. The protector 7 is provided on the inner surface of the protector 7 and has a plurality of inner surface ribs 83 that can come into contact with the outer surface ribs 39a and 39b of the mixed injection needle 3, and a mixed injection needle as in the embodiments described later. 3 and the inner rib 83 of the protector 70 are provided with an inner rib of the protector 70 when a torque equal to or greater than a predetermined torque is applied to the protector 70 in a direction in which the mixed injection needle 3 is fastened to the nozzle portion 22 of the outer cylinder 2. 83 may be able to get over the outer surface ribs 39a and 39b of the mixed injection needle 3.
Furthermore, in the medicine mixed injection devices of all the embodiments described above, the outer surface ribs 39a and 39b of the mixed injection needle 3 and the inner surface rib 83 of the protector 70 are moved over the outer surface ribs 39a and 39b of the inner surface rib 83 to the protector 70. When rotational torque is applied in a direction in which the mixed injection needle 3 is relaxed from the nozzle portion 22 of the outer cylinder 2, the inner rib 83 of the protector 70 comes into contact with the outer ribs 39 a and 39 b of the mixed injection needle 3. It may be possible to rotate the outer cylinder 2 in the direction of relaxation from the nozzle portion 22.

Next, a drug mixed injection device according to another embodiment of the present invention will be described.
The drug mixed injection device of this embodiment has substantially the same configuration as the above-described drug mixed injection device 1. The substantial difference is only the torque transmission mechanism by the inner surface rib 83 of the protector 70 and the outer surface rib 39 of the mixed injection needle 3.
Similarly to the embodiment described above with reference to FIGS. 1 to 18, the medicine co-infusion device includes an outer cylinder main body 21 and an outer cylinder 2 provided with a nozzle portion 22 provided at the distal end of the outer cylinder main body 21 and having an open front end. A sealing member 4 for sealing the nozzle portion 22, a gasket 5 slidably housed in the outer cylinder 2, a pusher 6 attached to or attachable to the rear end of the gasket, and an outer cylinder A prefilled syringe 10 composed of a medicine 8 filled in 2, a mixed injection needle 3 that can be attached to the nozzle portion 22 of the outer cylinder 2, and can be punctured into a mixed injection port of a medical container containing a chemical solution; It consists of a protector attached to the needle 3.

And also in this chemical | medical agent mixed injection instrument, the nozzle part 22 of the outer cylinder 2 is provided with the rib 25 for engagement provided in the outer surface of the nozzle part 22 similarly to the Example mentioned above, and the mixed injection needle 3 is a nozzle part. 22 are provided with inner ribs 37a and 37b that can be engaged with or engaged with the engagement ribs 25, and a plurality of outer ribs 39a and 39b provided on the outer surface of the mixed injection needle. The protector 7 includes a plurality of inner surface ribs 83 that are provided on the inner surface of the protector 7 and that can come into contact with the outer surface ribs 39a and 39b of the mixed injection needle 3.
In the medicine mixed injection device, as shown in FIGS. 21 to 26, the outer surface rib of the mixed injection needle 3 and the inner surface rib 83 of the protector 70 are connected to the protector 70 and the mixed injection needle 3 to the nozzle portion 22 of the outer cylinder 2. When a torque equal to or greater than a predetermined torque is applied in the fastening direction, the inner rib 83 of the protector 70 can get over the outer ribs 39a and 39b of the mixed injection needle 3.

FIG. 21 is a front view of a needle package for mixed injection used in a drug mixed injection device of another embodiment of the present invention. 22 is a front view showing a state where a cap member is removed from the mixed injection needle package shown in FIG. 21. FIG. 23 is a cross-sectional view of FIG. 24 is an enlarged left side view of the protector of the mixed injection needle package shown in FIG. FIG. 25 is an enlarged sectional view taken along the line DD of FIG. FIG. 26 is an explanatory view for explaining the medicine mixed injection device of this embodiment.
The outer ribs 39a and 39b of the mixed injection needle 3 and the inner rib 83 of the protector 70 are passed over the outer ribs 39a and 39b of the inner rib 83, and the mixed injection needle 3 is inserted into the protector 70 at the nozzle portion 22 of the outer cylinder 2. When rotational torque is applied in a more relaxed direction, the inner rib 83 of the protector 70 comes into contact with the outer ribs 39a and 39b of the mixed injection needle 3 and relaxes from the nozzle portion 22 of the outer cylinder 2 of the mixed injection needle 3. It is preferable that the rotation is possible.

As shown in FIG. 21, in the medicine mixed injection device of this embodiment, a mixed injection needle package is used, and the mixed injection needle package covers the mixed injection needle 3 and the needle portion side of the mixed injection needle 3. A protector 70 for wrapping and a cap member 9 for covering the base side of the mixed injection needle are provided. The mixed injection needle 3 is the same as described above, and the above description is referred to.
As shown in FIG. 24, the protector 70 includes a plurality of inner surface ribs 83 that can come into contact with the outer surface ribs 39 a and 39 b of the mixed injection needle 3. The inner rib 83 in this embodiment is an inclined rib having a low counterclockwise side in FIG. 24 and a high clockwise side. That is, the front end surface of the inner surface rib 83 is an inclined surface 83a that increases in the clockwise direction in FIG. Then, as shown in FIG. 25, when the protector 70 is rotated in the direction (arrow direction) in which the mixed injection needle 3 is fastened to the nozzle portion 22 of the outer cylinder 2, the corner portion of the outer surface rib 39a of the mixed injection needle 3 Comes into contact with the inclined surface 83 a of the inner rib, and the mixed injection needle 3 rotates together with the protector 70 and is fastened to the nozzle portion 22. After the mixed injection needle 3 is fastened to the nozzle portion 22, when a torque greater than a predetermined torque is applied to the protector 70, the inclined surface 83 a of the inner surface rib 83 of the protector 70 causes the outer ribs 39 a and 39 b of the mixed injection needle 3. The state shown in FIG. 26 is obtained. For this reason, excessive torque is not given to the mixed injection needle 3, and there is no excessive fastening of the mixed injection needle 3 to the nozzle portion 22 of the outer cylinder. In this embodiment, the inner rib 83 of the protector 70 is low on the fastening direction side and high on the relaxation direction side.

Further, in the state where the inner rib 83 of the protector 70 of FIG. 26 has passed over the outer ribs 39a and 39b of the mixed injection needle 3, the protector 70 causes the mixed injection needle 3 to relax from the nozzle portion 22 of the outer cylinder 2 (see FIG. When the rotational torque (in the direction of the arrow 26) is applied, the side surface portion of the most protruding vertex 83b of the inner surface rib 83 of the protector 70 comes into contact with the outer surface ribs 39a and 39b of the mixed injection needle 3. For this reason, torque can be sufficiently transmitted to the outer ribs, and the mixed injection needle 3 can be relaxed from the nozzle portion 22 of the outer cylinder 2.
As shown in FIGS. 25 and 26, the corners of the outer ribs 39a and 39b of the mixed injection needle 3 that are in contact with the side surfaces of the apex 83b of the inner rib 83 of the protector 70 are not chamfered. preferable. By doing in this way, torque can be more reliably transmitted to the outer surface rib.

In addition, the torque transmission mechanism by the inner surface rib 83 of a protector and the outer surface rib 39 of a co-injection needle | hook is not limited to the form mentioned above. For example, it may be as shown in FIGS. FIG. 27 and FIG. 28 are explanatory views for explaining a medicine mixed injection device according to another embodiment of the present invention. In the embodiment described above, the inner rib of the protector has an inclined surface, but in this embodiment, the outer surface ribs 38a and 39b of the mixed injection needle 3a are provided with an inclined surface 39c. The outer surface ribs 39a and 39b of the mixed injection needle 3a have an inclined surface 39c that is high on the fastening direction side and low on the relaxation direction side.
As shown in FIG. 27, when the protector 70a is rotated in a direction (arrow direction) in which the mixed injection needle 3a is fastened to the nozzle portion 22 of the outer cylinder 2, the corner portion of the inner rib 83 of the protector 70a is mixed. The mixed injection needle 3 a rotates together with the protector 70 a and is fastened to the nozzle portion 22 by coming into contact with the inclined surface 39 c of the outer surface rib 39 a of the needle 3 a. However, after the mixed injection needle 3 a is fastened to the nozzle portion 22, the inner rib 83 of the protector 70 a is further exposed to the outer ribs 39 a and 39 b of the mixed injection needle 3 when a torque greater than a predetermined torque is applied to the protector 70 a. 28, the state shown in FIG. 28 is obtained. For this reason, excessive torque is not given to the mixed injection needle 3a, and there is no excessive fastening of the mixed injection needle 3a to the nozzle portion 22 of the outer cylinder.

Further, in the state where the inner rib 83 of the protector 70a shown in FIG. 28 gets over the outer ribs 39a and 39b of the mixed injection needle 3, the protector 70a causes the mixed injection needle 3a to relax from the nozzle portion 22 of the outer cylinder 2 ( When the rotational torque in the direction of the arrow in FIG. 26 is applied, the inner surface rib 83 of the protector 70a comes into contact with the side surface portion of the most protruding vertex 39d of the outer surface ribs 39a and 39b of the mixed injection needle 3. Therefore, torque can be sufficiently transmitted to the outer surface ribs 39a and 39b, and the mixed injection needle 3a can be relaxed from the nozzle portion 22 of the outer cylinder 2.
And it is preferable that the corner | angular part of the inner surface rib 83 of the protector 70a used as the part contact | abutted with the side part of the vertex 39d of the outer surface rib of the mixed injection needle 3 is not chamfered. By doing in this way, torque can be more reliably transmitted to the outer surface rib.

FIG. 1 is an external view of a medicine mixed injection device of the present invention. FIG. 2 is an external view of the medicine co-infusion apparatus of the present invention in a state where co-infusion is possible. FIG. 3 is a front view of an outer cylinder of a prefilled syringe used in the medicine co-infusion apparatus of the present invention. FIG. 4 is a cross-sectional view of the outer cylinder of FIG. FIG. 5 is a right side view of the outer cylinder shown in FIG. FIG. 6 is a front view of a co-injection needle used in the drug co-infusion apparatus of the present invention. FIG. 7 is an external view of the mixed injection needle of FIG. 6 in a state where the needle is rotated by a predetermined angle. FIG. 8 is a right side view of the mixed injection needle shown in FIG. 6. FIG. 9 is a left side view of the mixed injection needle shown in FIG. 10 is a cross-sectional view taken along line AA in FIG. 11 is a cross-sectional view taken along line BB in FIG. 12 is a cross-sectional view taken along the line CC of FIG. FIG. 13 is an explanatory diagram for explaining a state in which a mixed injection needle is attached to the nozzle portion of the outer cylinder. FIG. 14: is a front view of the protector for mixed injection needles used for the chemical injection device of this invention. 15 is a cross-sectional view taken along the line DD of FIG. 16 is a right side view of the mixed needle protector of FIG. FIG. 17 is a left side view of the mixed needle protector of FIG. FIG. 18 is a cross-sectional view of a mixed injection needle with a mixed injection needle protector attached thereto. FIG. 19 is an explanatory diagram for explaining a protector used in a medicine mixed injection device according to another embodiment of the present invention. FIG. 20 is an explanatory view for explaining a protector used in a medicine mixed injection device according to another embodiment of the present invention. FIG. 21 is a front view of a needle package for mixed injection used in a drug mixed injection device of another embodiment of the present invention. 22 is a front view showing a state where a cap member is removed from the mixed injection needle package shown in FIG. 21. FIG. 23 is a cross-sectional view of FIG. 24 is an enlarged left side view of the protector of the mixed injection needle package shown in FIG. FIG. 25 is an enlarged sectional view taken along the line DD of FIG. FIG. 26 is an explanatory view for explaining the medicine mixed injection device of this embodiment. FIG. 27 is an explanatory diagram for explaining a drug mixed injection device according to another embodiment of the present invention. FIG. 28 is an explanatory view for explaining a drug mixed injection device according to another embodiment of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Drug mixed injection instrument 2 Outer cylinder 3 Mixed injection needle 4 Sealing member 5 Gasket 6 Pusher 7 Protector 10 Prefilled syringe 21 Outer cylinder main body part 22 Nozzle part 23 Inner cylinder part 24 Outer cylinder part 38 Middle cylinder part 33 Cylindrical part 32 Puncture needle (first area)
36a, 36b, 36c Side hole 52 Second region 53 Third region 54 Fourth region

Claims (9)

An outer cylinder provided with an outer cylinder main body, a nozzle provided at the distal end of the outer cylinder main body and having an opening at the tip, a sealing member for sealing the nozzle, and slidable within the outer cylinder A stored gasket, a pusher attached to or attachable to the rear end of the gasket, a prefilled syringe made of a medicine filled in the outer cylinder, and the nozzle portion after the sealing member is detached A drug co-injection device for a medical container comprising a co-infusion needle that can be mounted and pierced into a co-infusion port of a medical container containing a medical solution,
The nozzle portion of the outer cylinder includes an inner cylinder portion that protrudes outward from a front end surface of the outer cylinder main body portion, an outer cylinder portion that is provided so as to enclose the inner cylinder portion, comprising a engagement outer ribs provided on the outer surface, and the difference of the inner diameter of the distal end portion of the outer diameter of the distal end portion of the inner cylinder portion and the outer cylindrical portion is 0.5 mm to 1.5 mm, the outer The inner diameter of the distal end portion of the tube portion is 2 to 3 mm or 6 to 10 mm , and a normal standard female female connection portion having a taper of 6% is not connectable . A needle main body, a middle cylinder provided at a proximal end of the needle main body, and capable of entering between the outer cylinder and the inner cylinder of the nozzle and forming a liquid-tight state; and the middle cylinder A cylindrical portion having an inner rib for engagement that can be engaged with or screwed with the outer rib for engagement of the nozzle portion on the inner surface, and the needle Comprising the puncture needle portion provided at a front end portion of the body, located in 10~25mm proximal side of the distal end of the mixed injection needle, and a side hole communicating with the mixed injection needle inside and the outside, the mixed injection communicating said needle interior for mixed injection and the inside of the medical container is only when the use needle is punctured into the mixture injection port of the medical container at least to the lateral hole position, and wherein Rukoto Do allow injection of drugs Drug co-injection device for medical containers. An outer cylinder provided with an outer cylinder main body, a nozzle provided at the tip of the outer cylinder main body and having an opening at the tip; a gasket slidably housed in the outer cylinder; and a rear end of the gasket To a medical container comprising a prefilled syringe comprising an attached or attachable pusher, and a mixed injection needle that can be attached to the nozzle portion and can be pierced into a mixed injection port of a medical container containing a medical solution. A medicine co-infusion device,
The nozzle portion of the outer cylinder includes an inner cylinder portion that protrudes outward from a front end surface of the outer cylinder main body portion, an outer cylinder portion that is provided so as to enclose the inner cylinder portion, comprising a engagement outer ribs provided on the outer surface, and the difference of the inner diameter of the distal end portion of the outer diameter of the distal end portion of the inner cylinder portion and the outer cylindrical portion is 0.5 mm to 1.5 mm, the outer The inner diameter of the distal end of the cylindrical portion is 2 to 3 mm or 6.0 to 10 mm , and a normal standard female female connecting portion having a taper of 6% cannot be connected . Further, the mixed injection needle Is provided at the proximal end portion of the needle main body portion, a middle cylinder portion capable of entering between the outer cylinder portion and the inner cylinder portion of the nozzle portion and forming a liquid-tight state, A cylindrical portion that encloses the cylindrical portion and has an inner rib that can be engaged or screwed with the outer rib for engagement of the nozzle portion on the inner surface, and the needle book Parts and the puncture needle portion provided at a front end portion of the located 10~25mm proximal side of the distal end of the mixed injection needle, and a side hole communicating with the mixed injection needle inside and the outside, for the mixed injection needle through the communicating said needle interior for mixed injection and the inside of the medical container is only when punctured mixture injection port of the medical container at least to the lateral hole position, characterized Rukoto Do allow injection of drugs Drug co-injection device for medical containers. The drug mixed injection device according to claim 1 or 2, wherein the engaging outer rib is a spiral rib. The medicine co-infusion device according to any one of claims 1 to 3, wherein the engaging inner ribs are the plurality of discontinuous short ribs. The medicine co-injection device according to any one of claims 1 to 4, wherein the inner tube portion of the nozzle portion has no taper or a cylindrical shape having a taper of 5.5% or less . The medicine mixture injection device according to any one of claims 1 to 5, wherein the mixture injection needle includes a plurality of the side holes. The needle body portion of the mixed injection needle has a first region having an acute taper angle that forms a puncture end from the distal end side, and a second taper that is continuous with the first region and has no gentle taper angle or taper angle. A region that is continuous with the second region and has a taper angle larger than the taper angle of the second region by a predetermined angle, and a fourth region that is continuous with the third region and has no gentle taper angle or taper angle. The medicine co-infusion device according to any one of claims 1 to 6 , which has a region. The said side hole is a chemical | medical agent co-infusion device of Claim 7 provided in the front-end | tip part of the said 3rd area | region or the said 4th area | region. The mixed medicine injection device includes a protector attached to the mixed injection needle, the mixed injection needle has a plurality of outer surface ribs provided on an outer surface of the mixed injection needle, and the protector includes an inner surface of the protector. And a plurality of inner surface ribs that can come into contact with the outer surface ribs of the mixed injection needle, and a marker unit that is provided on the outer surface of the protector and recognizes a non-arranged portion of the inner surface ribs. Item 9. A drug co-infusion device according to any one of Items 1 to 8 .

Images