JP4751661B2 - 細胞に制御された炎症性応答を起こさせるための血管内装置 - Google Patents
細胞に制御された炎症性応答を起こさせるための血管内装置 Download PDFInfo
- Publication number
- JP4751661B2 JP4751661B2 JP2005225833A JP2005225833A JP4751661B2 JP 4751661 B2 JP4751661 B2 JP 4751661B2 JP 2005225833 A JP2005225833 A JP 2005225833A JP 2005225833 A JP2005225833 A JP 2005225833A JP 4751661 B2 JP4751661 B2 JP 4751661B2
- Authority
- JP
- Japan
- Prior art keywords
- aneurysm
- coil
- growth factor
- intravascular device
- biocompatible
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/1214—Coils or wires
- A61B17/1215—Coils or wires comprising additional materials, e.g. thrombogenic, having filaments, having fibers, being coated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/04—Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/30062—(bio)absorbable, biodegradable, bioerodable, (bio)resorbable, resorptive
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
- A61F2002/30003—Material related properties of the prosthesis or of a coating on the prosthesis
- A61F2002/3006—Properties of materials and coating materials
- A61F2002/3008—Properties of materials and coating materials radio-opaque, e.g. radio-opaque markers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0004—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof bioabsorbable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
Description
Claims (4)
- 動脈瘤の細胞に炎症性応答を起こさせて創傷の治癒作用を促すことにより動脈瘤の治療に使用するための血管内装置であって、
分離可能なコイルと、当該コイルと連結されていて当該コイルを動脈瘤中に配置する血管内配置装置とを備えてなり、
前記分離可能なコイルは、その少なくとも一部が、ポリグリコール酸とポリ−L−乳酸との共重合体、ポリカプロラクティブ、ポリヒドロキシブチレートとヒドロキシバレレートとの共重合体、ポリ−L−ラクチド、ポリジオキサノン、ポリカーボネートおよびポリ酸無水物からなる群から選択される少なくとも一種の生物適合性でかつ生物分解性の重合体で構成され、かつ、少なくとも一部に成長因子を有して構成されており、動脈瘤中に配置されたとき、動脈瘤の細胞に対する刺激により当該細胞に炎症性応答を起こさせてその創傷の治癒作用を続いて促すような制御された刺激を動脈瘤の細胞に与えるよう構成されている
ことを特徴とする血管内装置。 - 請求項1に記載の血管内装置において、
前記成長因子が血管内皮細胞成長因子、塩基性繊維芽細胞成長因子またはその混合物からなる群から選択される一つである
ことを特徴とする装置。 - 請求項1に記載の血管内装置において、
前記コイルが前記生物適合性でかつ生物分解性の重合体および前記成長因子を有して構成され、その上に放射線不透過性材料が配置されている
ことを特徴とする装置。 - 請求項1に記載の血管内装置において、
前記コイルが放射線不透過性材料で構成され、その上に前記生物適合性でかつ生物分解性の重合体および前記成長因子が配置されている
ことを特徴とする装置。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US1999/001790 WO1999044538A1 (en) | 1998-01-27 | 1999-01-27 | Biodegradable polymer/protein based coils for intralumenal implants |
USUS9901790 | 1999-01-27 |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000595611A Division JP2003524456A (ja) | 1999-01-27 | 1999-09-27 | 内腔移植体として用いる生物分解性重合体タンパク質ベースのコイル |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2006021052A JP2006021052A (ja) | 2006-01-26 |
JP4751661B2 true JP4751661B2 (ja) | 2011-08-17 |
Family
ID=22272061
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000595611A Pending JP2003524456A (ja) | 1999-01-27 | 1999-09-27 | 内腔移植体として用いる生物分解性重合体タンパク質ベースのコイル |
JP2004051278A Pending JP2004223268A (ja) | 1999-01-27 | 2004-02-26 | 生物吸収性重合体ベースのコイルによる血管内炎症性応答法 |
JP2005225833A Expired - Lifetime JP4751661B2 (ja) | 1999-01-27 | 2005-08-03 | 細胞に制御された炎症性応答を起こさせるための血管内装置 |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2000595611A Pending JP2003524456A (ja) | 1999-01-27 | 1999-09-27 | 内腔移植体として用いる生物分解性重合体タンパク質ベースのコイル |
JP2004051278A Pending JP2004223268A (ja) | 1999-01-27 | 2004-02-26 | 生物吸収性重合体ベースのコイルによる血管内炎症性応答法 |
Country Status (5)
Country | Link |
---|---|
EP (1) | EP1156759A4 (ja) |
JP (3) | JP2003524456A (ja) |
AU (1) | AU6402699A (ja) |
CA (1) | CA2323151C (ja) |
WO (1) | WO2000044306A1 (ja) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7070607B2 (en) | 1998-01-27 | 2006-07-04 | The Regents Of The University Of California | Bioabsorbable polymeric implants and a method of using the same to create occlusions |
US7018401B1 (en) | 1999-02-01 | 2006-03-28 | Board Of Regents, The University Of Texas System | Woven intravascular devices and methods for making the same and apparatus for delivery of the same |
US6368346B1 (en) | 1999-06-03 | 2002-04-09 | American Medical Systems, Inc. | Bioresorbable stent |
US20030004533A1 (en) * | 2001-05-04 | 2003-01-02 | Concentric Medical | Bioactive polymer vaso-occlusive device |
US6585754B2 (en) | 2001-05-29 | 2003-07-01 | Scimed Life Systems, Inc. | Absorbable implantable vaso-occlusive member |
CA2452412C (en) | 2001-06-29 | 2011-05-24 | Medgraft Microtech, Inc. | Biodegradable injectable implants and related methods of manufacture and use |
US8715312B2 (en) | 2001-07-20 | 2014-05-06 | Microvention, Inc. | Aneurysm treatment device and method of use |
US8252040B2 (en) | 2001-07-20 | 2012-08-28 | Microvention, Inc. | Aneurysm treatment device and method of use |
US7572288B2 (en) | 2001-07-20 | 2009-08-11 | Microvention, Inc. | Aneurysm treatment device and method of use |
US8845676B2 (en) | 2004-09-22 | 2014-09-30 | Micro Therapeutics | Micro-spiral implantation device |
WO2006032289A1 (de) | 2004-09-22 | 2006-03-30 | Dendron Gmbh | Medizinisches implantat |
US8864790B2 (en) | 2006-04-17 | 2014-10-21 | Covidien Lp | System and method for mechanically positioning intravascular implants |
US9895242B2 (en) | 2006-10-22 | 2018-02-20 | Idev Technologies, Inc. | Secured strand end devices |
JP5455633B2 (ja) | 2006-10-22 | 2014-03-26 | アイデブ テクノロジーズ インコーポレイテッド | ステント前進のためのデバイスおよび方法 |
JP5249249B2 (ja) | 2007-03-13 | 2013-07-31 | コヴィディエン リミテッド パートナーシップ | コイルと耐伸張性部材とが含まれているインプラント |
US9023094B2 (en) | 2007-06-25 | 2015-05-05 | Microvention, Inc. | Self-expanding prosthesis |
US9023095B2 (en) | 2010-05-27 | 2015-05-05 | Idev Technologies, Inc. | Stent delivery system with pusher assembly |
DE102011007134A1 (de) | 2011-04-11 | 2012-10-11 | Basf Se | Verfahren zur Herstellung eines Polyamids durch anionische Polymerisation |
WO2012155093A1 (en) | 2011-05-11 | 2012-11-15 | Microvention, Inc. | Device for occluding a lumen |
US9579104B2 (en) | 2011-11-30 | 2017-02-28 | Covidien Lp | Positioning and detaching implants |
US9011480B2 (en) | 2012-01-20 | 2015-04-21 | Covidien Lp | Aneurysm treatment coils |
US9687245B2 (en) | 2012-03-23 | 2017-06-27 | Covidien Lp | Occlusive devices and methods of use |
US9655999B2 (en) | 2013-03-12 | 2017-05-23 | Carnegie Mellon University | Coated vaso-occlusive device for treatment of aneurysms |
US9713475B2 (en) | 2014-04-18 | 2017-07-25 | Covidien Lp | Embolic medical devices |
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US5843156A (en) * | 1988-08-24 | 1998-12-01 | Endoluminal Therapeutics, Inc. | Local polymeric gel cellular therapy |
US4994069A (en) * | 1988-11-02 | 1991-02-19 | Target Therapeutics | Vaso-occlusion coil and method |
US5464650A (en) * | 1993-04-26 | 1995-11-07 | Medtronic, Inc. | Intravascular stent and method |
US5549624A (en) * | 1994-06-24 | 1996-08-27 | Target Therapeutics, Inc. | Fibered vasooclusion coils |
NO962336L (no) * | 1995-06-06 | 1996-12-09 | Target Therapeutics Inc | Vaso-okklusiv spiral |
US5624461A (en) * | 1995-06-06 | 1997-04-29 | Target Therapeutics, Inc. | Three dimensional in-filling vaso-occlusive coils |
US5853418A (en) * | 1995-06-30 | 1998-12-29 | Target Therapeutics, Inc. | Stretch resistant vaso-occlusive coils (II) |
DK0754435T3 (da) * | 1995-06-30 | 2000-11-27 | Target Therapeutics Inc | Strækningsmodstandsdygtige karokklusionsspiraler |
CA2186768C (en) * | 1995-09-29 | 2000-12-12 | Pete Phong Pham | Anatomically shaped vasoocclusive devices |
US5830879A (en) * | 1995-10-02 | 1998-11-03 | St. Elizabeth's Medical Center Of Boston, Inc. | Treatment of vascular injury using vascular endothelial growth factor |
US6007573A (en) * | 1996-09-18 | 1999-12-28 | Microtherapeutics, Inc. | Intracranial stent and method of use |
US5891192A (en) * | 1997-05-22 | 1999-04-06 | The Regents Of The University Of California | Ion-implanted protein-coated intralumenal implants |
JP4355038B2 (ja) * | 1997-09-01 | 2009-10-28 | 株式会社カネカメディックス | 血管塞栓用具 |
WO1999044538A1 (en) * | 1998-01-27 | 1999-09-10 | The Regents Of The University Of California | Biodegradable polymer/protein based coils for intralumenal implants |
US5935145A (en) * | 1998-02-13 | 1999-08-10 | Target Therapeutics, Inc. | Vaso-occlusive device with attached polymeric materials |
US6015424A (en) * | 1998-04-28 | 2000-01-18 | Microvention, Inc. | Apparatus and method for vascular embolization |
-
1999
- 1999-09-27 WO PCT/US1999/022420 patent/WO2000044306A1/en active Search and Examination
- 1999-09-27 EP EP99951622A patent/EP1156759A4/en not_active Ceased
- 1999-09-27 CA CA002323151A patent/CA2323151C/en not_active Expired - Lifetime
- 1999-09-27 JP JP2000595611A patent/JP2003524456A/ja active Pending
- 1999-09-27 AU AU64026/99A patent/AU6402699A/en not_active Abandoned
-
2004
- 2004-02-26 JP JP2004051278A patent/JP2004223268A/ja active Pending
-
2005
- 2005-08-03 JP JP2005225833A patent/JP4751661B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP1156759A4 (en) | 2002-11-20 |
CA2323151A1 (en) | 2000-08-03 |
JP2003524456A (ja) | 2003-08-19 |
CA2323151C (en) | 2007-04-10 |
WO2000044306A1 (en) | 2000-08-03 |
AU6402699A (en) | 2000-08-18 |
JP2004223268A (ja) | 2004-08-12 |
JP2006021052A (ja) | 2006-01-26 |
EP1156759A1 (en) | 2001-11-28 |
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