JP4719911B2 - 診断薬 - Google Patents
診断薬 Download PDFInfo
- Publication number
- JP4719911B2 JP4719911B2 JP2008528786A JP2008528786A JP4719911B2 JP 4719911 B2 JP4719911 B2 JP 4719911B2 JP 2008528786 A JP2008528786 A JP 2008528786A JP 2008528786 A JP2008528786 A JP 2008528786A JP 4719911 B2 JP4719911 B2 JP 4719911B2
- Authority
- JP
- Japan
- Prior art keywords
- diagnostic agent
- pigment
- wall
- present
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/006—Biological staining of tissues in vivo, e.g. methylene blue or toluidine blue O administered in the buccal area to detect epithelial cancer cells, dyes used for delineating tissues during surgery
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/42—Detecting, measuring or recording for evaluating the gastrointestinal, the endocrine or the exocrine systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B1/00—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor
- A61B1/273—Instruments for performing medical examinations of the interior of cavities or tubes of the body by visual or photographical inspection, e.g. endoscopes; Illuminating arrangements therefor for the upper alimentary canal, e.g. oesophagoscopes, gastroscopes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Surgery (AREA)
- Medical Informatics (AREA)
- Biodiversity & Conservation Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Description
0.4重量%インジゴカルミン水溶液(第一製薬株式会社製)25mlと1.5重量%酢酸水溶液15mlを混合して本発明の診断薬を得た。得られた診断薬は、インジゴカルミンの濃度が5.3mmol/Lであり、酢酸の濃度が0.1mol/Lであり、pHが3.0であった。
68才の男性患者の胃内に上部消化管内視鏡電子スコープを挿入して内視鏡検査を行ったところ、図1で示されるように病変の存在を明瞭に確認することができなかった。0.4重量%インジゴカルミン水溶液(第一製薬株式会社製)のみを胃の内壁に散布したところ、図2で示されるように疑わしい病変部位は観察されたが、病変部位の明確な同定はできなかった。上記胃の内壁を注射用蒸留水を用いて洗い流した後に、上記方法により得られた本発明の診断薬を胃の内壁に散布したところ、図3で示されるように青色に着色された正常粘膜を背景にして赤色の陥凹病変部位が明確に観察された。この病変部位を内視鏡的粘膜下層剥離術により摘出したところ、高分化型腺癌が確認された。
29才の男性患者の胃内に上部消化管内視鏡電子スコープを挿入して内視鏡検査を行ったところ、図4で示されるように病変の存在を明瞭に確認することができなかった。0.4重量%インジゴカルミン水溶液(第一製薬株式会社製)のみを胃の内壁に散布したところ、図5で示されるように疑わしい病変部位は観察されたが、病変部位の明確な同定はできなかった。上記胃の内壁を注射用蒸留水を用いて洗い流した後に、上記方法により得られた本発明の診断薬を胃の内壁に散布したところ、図6で示されるように青色に着色された線状の陥凹で囲まれた病変部位が明確に観察された。この病変部位を外科的切除により摘出したところ、印鑑細胞癌が確認された。内視鏡を用いた診断により印鑑細胞癌の伸長範囲を特定することは非常に困難であることから、本発明の診断薬が非常に有用であることが分かる。
Claims (3)
- 内視鏡で観察する際に消化器の内壁に散布するための診断薬であって、インジゴカルミン(食用青色2号)、クチナシ青色素又はカラメル色素から選択される色素を含有するpH2〜4の酢酸水溶液からなることを特徴とする診断薬。
- 前記色素がインジゴカルミン(食用青色2号)である請求項1記載の診断薬。
- 前記酢酸の濃度が0.01〜1mol/Lである請求項1又は2記載の診断薬。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2008528786A JP4719911B2 (ja) | 2006-08-08 | 2007-07-31 | 診断薬 |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2006215437 | 2006-08-08 | ||
JP2006215437 | 2006-08-08 | ||
JP2008528786A JP4719911B2 (ja) | 2006-08-08 | 2007-07-31 | 診断薬 |
PCT/JP2007/065012 WO2008018327A1 (fr) | 2006-08-08 | 2007-07-31 | Agent de diagnostic |
Publications (2)
Publication Number | Publication Date |
---|---|
JPWO2008018327A1 JPWO2008018327A1 (ja) | 2009-12-24 |
JP4719911B2 true JP4719911B2 (ja) | 2011-07-06 |
Family
ID=39032861
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008528786A Expired - Fee Related JP4719911B2 (ja) | 2006-08-08 | 2007-07-31 | 診断薬 |
Country Status (5)
Country | Link |
---|---|
US (2) | US20090246135A1 (ja) |
EP (1) | EP2050469B1 (ja) |
JP (1) | JP4719911B2 (ja) |
KR (1) | KR101429576B1 (ja) |
WO (1) | WO2008018327A1 (ja) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0503738D0 (en) | 2005-02-23 | 2005-03-30 | Optinose As | Powder delivery devices |
WO2010018723A1 (ja) * | 2008-08-12 | 2010-02-18 | マイラン製薬株式会社 | 液状インジゴカルミン製剤 |
US10463229B2 (en) * | 2010-10-22 | 2019-11-05 | Fukuoka University | Endoscopic observation method and composition for improving diagnostic performance involving applying useful white opaque substance to diagnosis of gastric epithelial tumors (adenoma or gastric cancer) |
AU2015212418B2 (en) * | 2014-01-29 | 2020-01-23 | Cosmo Technologies Limited | Liquid composition in the form of emulsion or microemulsion for rectal administration containing at least one dye, and its use in a diagnostic endoscopic procedure of sigmoid colon and/or rectum |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3251186B2 (ja) | 1997-01-10 | 2002-01-28 | 宗明 佐野 | 手術用生体マーキング製剤 |
JP3943008B2 (ja) * | 2002-08-28 | 2007-07-11 | 日本電信電話株式会社 | オゾンガスの検知素子および検出装置ならびに検出方法 |
-
2007
- 2007-07-31 US US12/310,019 patent/US20090246135A1/en not_active Abandoned
- 2007-07-31 KR KR1020097004745A patent/KR101429576B1/ko not_active IP Right Cessation
- 2007-07-31 EP EP07791696.3A patent/EP2050469B1/en not_active Expired - Fee Related
- 2007-07-31 WO PCT/JP2007/065012 patent/WO2008018327A1/ja active Search and Examination
- 2007-07-31 JP JP2008528786A patent/JP4719911B2/ja not_active Expired - Fee Related
-
2011
- 2011-08-04 US US13/137,295 patent/US8388934B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20090246135A1 (en) | 2009-10-01 |
JPWO2008018327A1 (ja) | 2009-12-24 |
WO2008018327A1 (fr) | 2008-02-14 |
KR101429576B1 (ko) | 2014-08-12 |
EP2050469B1 (en) | 2014-05-28 |
EP2050469A1 (en) | 2009-04-22 |
US20110293523A1 (en) | 2011-12-01 |
EP2050469A4 (en) | 2011-04-06 |
KR20090053805A (ko) | 2009-05-27 |
US8388934B2 (en) | 2013-03-05 |
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