JP4646671B2 - A topical skin preparation containing an activated carbon-treated plum extract - Google Patents
A topical skin preparation containing an activated carbon-treated plum extract Download PDFInfo
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- JP4646671B2 JP4646671B2 JP2005099937A JP2005099937A JP4646671B2 JP 4646671 B2 JP4646671 B2 JP 4646671B2 JP 2005099937 A JP2005099937 A JP 2005099937A JP 2005099937 A JP2005099937 A JP 2005099937A JP 4646671 B2 JP4646671 B2 JP 4646671B2
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- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 title claims description 62
- 239000000284 extract Substances 0.000 title claims description 44
- 238000002360 preparation method Methods 0.000 title claims description 28
- 230000000699 topical effect Effects 0.000 title description 3
- 235000013372 meat Nutrition 0.000 claims description 26
- 230000003020 moisturizing effect Effects 0.000 claims description 23
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 10
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 10
- 239000003795 chemical substances by application Substances 0.000 claims description 7
- 229920002683 Glycosaminoglycan Polymers 0.000 claims description 6
- 235000001014 amino acid Nutrition 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 229920005862 polyol Polymers 0.000 claims description 6
- 150000003077 polyols Chemical class 0.000 claims description 6
- 235000011187 glycerol Nutrition 0.000 claims description 5
- 150000003839 salts Chemical class 0.000 claims description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 4
- 229920002971 Heparan sulfate Polymers 0.000 claims description 4
- 239000003906 humectant Substances 0.000 claims description 3
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 2
- 229940058015 1,3-butylene glycol Drugs 0.000 claims description 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 claims description 2
- 239000004475 Arginine Substances 0.000 claims description 2
- 229920001287 Chondroitin sulfate Polymers 0.000 claims description 2
- 229920000045 Dermatan sulfate Polymers 0.000 claims description 2
- 239000004471 Glycine Substances 0.000 claims description 2
- HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 claims description 2
- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 claims description 2
- 229920000288 Keratan sulfate Polymers 0.000 claims description 2
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 2
- AHLPHDHHMVZTML-BYPYZUCNSA-N L-Ornithine Chemical compound NCCC[C@H](N)C(O)=O AHLPHDHHMVZTML-BYPYZUCNSA-N 0.000 claims description 2
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 2
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 2
- AHLPHDHHMVZTML-UHFFFAOYSA-N Orn-delta-NH2 Natural products NCCCC(N)C(O)=O AHLPHDHHMVZTML-UHFFFAOYSA-N 0.000 claims description 2
- UTJLXEIPEHZYQJ-UHFFFAOYSA-N Ornithine Natural products OC(=O)C(C)CCCN UTJLXEIPEHZYQJ-UHFFFAOYSA-N 0.000 claims description 2
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 2
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 2
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 2
- 239000004473 Threonine Substances 0.000 claims description 2
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 2
- 235000009697 arginine Nutrition 0.000 claims description 2
- 235000003704 aspartic acid Nutrition 0.000 claims description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 2
- 235000019437 butane-1,3-diol Nutrition 0.000 claims description 2
- 229940059329 chondroitin sulfate Drugs 0.000 claims description 2
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 2
- 235000018417 cysteine Nutrition 0.000 claims description 2
- AVJBPWGFOQAPRH-FWMKGIEWSA-L dermatan sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@H](OS([O-])(=O)=O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](C([O-])=O)O1 AVJBPWGFOQAPRH-FWMKGIEWSA-L 0.000 claims description 2
- 229940051593 dermatan sulfate Drugs 0.000 claims description 2
- 229940105990 diglycerin Drugs 0.000 claims description 2
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 claims description 2
- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 claims description 2
- 229960005150 glycerol Drugs 0.000 claims description 2
- 229960002897 heparin Drugs 0.000 claims description 2
- 229920002674 hyaluronan Polymers 0.000 claims description 2
- 229960003160 hyaluronic acid Drugs 0.000 claims description 2
- 229960002591 hydroxyproline Drugs 0.000 claims description 2
- KXCLCNHUUKTANI-RBIYJLQWSA-N keratan Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@H](COS(O)(=O)=O)O[C@H]1O[C@@H]1[C@@H](O)[C@H](O[C@@H]2[C@H](O[C@@H](O[C@H]3[C@H]([C@@H](COS(O)(=O)=O)O[C@@H](O)[C@@H]3O)O)[C@H](NC(C)=O)[C@H]2O)COS(O)(=O)=O)O[C@H](COS(O)(=O)=O)[C@@H]1O KXCLCNHUUKTANI-RBIYJLQWSA-N 0.000 claims description 2
- 229930182817 methionine Natural products 0.000 claims description 2
- 229960003104 ornithine Drugs 0.000 claims description 2
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 claims description 2
- 239000002156 adsorbate Substances 0.000 claims 1
- 239000006286 aqueous extract Substances 0.000 claims 1
- 239000011148 porous material Substances 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 24
- 230000000694 effects Effects 0.000 description 11
- 238000001914 filtration Methods 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 235000013305 food Nutrition 0.000 description 5
- 239000006210 lotion Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- FYDIRKLRXHXXHY-UHFFFAOYSA-N Mumefural Chemical compound OC(=O)CC(O)(C(O)=O)CC(=O)OCC1=CC=C(C=O)O1 FYDIRKLRXHXXHY-UHFFFAOYSA-N 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 239000004909 Moisturizer Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 230000001333 moisturizer Effects 0.000 description 3
- 150000007524 organic acids Chemical class 0.000 description 3
- 235000005985 organic acids Nutrition 0.000 description 3
- 239000008213 purified water Substances 0.000 description 3
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000001630 malic acid Substances 0.000 description 2
- 235000011090 malic acid Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000012935 Averaging Methods 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
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- 238000004108 freeze drying Methods 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036449 good health Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000037311 normal skin Effects 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- -1 packs Substances 0.000 description 1
- 235000021018 plums Nutrition 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
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- 239000002904 solvent Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
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- 210000002784 stomach Anatomy 0.000 description 1
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- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Description
本発明は皮膚外用剤に関し、更に詳細には、活性炭を用いることによって、不溶分、着色成分、クエン酸やリンゴ酸などの有機酸を選択的に除去した活性炭処理梅肉エキスを配合した皮膚外用剤に関する。 The present invention relates to an external preparation for skin, and more specifically, external use for skin containing activated charcoal-treated plum meat extract that selectively removes insoluble matter, coloring components, and organic acids such as citric acid and malic acid by using activated carbon. It relates to the agent.
梅肉エキスは日本の特有の食品で、昔から健康に良いと愛用されている。梅肉エキスは、クエン酸、リンゴ酸やコハク酸などの有機酸類が多量に含まれており、食物繊維や鉄分などが含まれている。酸味が強く、これが昔から殺菌、疲労回復、胃の保護作用を持つといわれている。梅干や梅肉エキスには血圧を上げる酵素ACEの活性を抑制する働きがあり、梅肉エキスは梅干と異なり、食塩が全く含まれていないため、食塩の摂取を制限されている人も安心して食べることができる。特に最近の研究では、梅肉エキスの中にムメフラール （Ｍｕｍｅｆｕｒａｌ）という成分が血流改善に良い働きがあることが分った（Ｃｈｕｄａ Ｙ． ｅｔ ａｌ．、Ｊ． Ａｇｒｉｃ． Ｆｏｏｄ Ｃｈｅｍ．、４７、ｐ８２８−８３１、(１９９９)）。 Plum meat extract is a unique Japanese food and has long been loved for its good health. Plum meat extract contains a large amount of organic acids such as citric acid, malic acid and succinic acid, and contains dietary fiber and iron. It has a strong acidity and has long been said to have sterilization, fatigue recovery, and stomach protection. Umeboshi and plum extract have a function to suppress the activity of ACE, an enzyme that raises blood pressure. Unlike plums, plum extract does not contain salt at all, so people who are restricted from taking salt can rest assured. I can eat. Particularly in recent studies, it has been found that a component called Mumefural has a good effect on blood flow improvement in plum extract (Chuda Y. et al., J. Agric. Food Chem., 47, p828-831, (1999)).
梅肉エキスの製造方法は、昔から伝統的に伝えられており、青梅の実をすりおろしてガーゼなどで果汁をろ過し、その後弱火で飴状になるまで長時間煮詰める。梅肉エキスは梅の実１ｋｇ分から20〜25gしか取れない。 The method of producing plum meat extract has been traditionally passed down, and the fruit of the ume is grated, the fruit juice is filtered with gauze, etc., and then boiled for a long time until it becomes a bowl-like shape on low heat. Plum meat extract can only take 20-25g from 1kg of plum fruit.
梅肉エキス中に含まれる血流改善作用を有するムメフラールは、生梅の状態では含まれておらず、梅肉エキス製造時の加熱処理によって、グルコース、フルクトースやスクロースなどの糖が脱水反応によって5−ヒドロキシメチル２−フルフラールを生成し、更にクエン酸がエステル縮合して生成することがわかっている。（我籐伸樹 他、ヘモレオロジー研究会誌、第3巻、ｐ８１−８７（２０００）） Mumefural, which has an effect of improving blood flow, contained in plum extract is not included in the state of raw plum, and sugars such as glucose, fructose and sucrose are dehydrated by heat treatment during the production of plum extract. It is known that -hydroxymethyl 2-furfural is produced, and citric acid is further produced by ester condensation. (Nobuki Iwatani et al., Journal of Hemorheology, Volume 3, p81-87 (2000))
ムメフラールの効能を発揮し、有機酸類を取り除く精製法としてカラムクロマトを用いる方法が提示されている（登録第２９７９３０５号）。しかし、カラムによる精製は単一成分にする能力は高いが処理に費用がかかり実用的でない。このようなことから、安価な方法で、酸味の主要因であるクエン酸を選択的に除き、ムメフラール含有比率の高いクエン酸低含有梅肉エキス組成物を製造する。 A method using column chromatography has been proposed as a purification method that demonstrates the efficacy of umefural and removes organic acids (Registration No. 2979305). However, purification by a column has a high ability to make a single component, but the processing is expensive and impractical. For this reason, citric acid, which is the main factor of acidity, is selectively removed by an inexpensive method, and a citric acid low-containing plum meat extract composition having a high content ratio of umefural is produced.
梅肉エキスは、このように食品への利用はされているが、皮膚外用剤への利用は、梅肉エキスの着色が強いこと、不溶性成分が多いこと、酸性度が強いことなどの問題点から使用には至っていないのが現状である。
解決しようとする問題点は、梅肉エキスの皮膚外用剤への配合であり、着色が強い、不溶性成分が多い、酸性度が強いを改善することによって、皮膚外用剤への配合ができ、皮膚への有効性が見出されることが望まれていた。更に、皮膚に対する有効性の確認し、皮膚外用剤への応用が望まれていた。 The problem to be solved is the blending of plum extract into a skin external preparation, which can be formulated into a skin external preparation by improving the strong coloring, many insoluble components and strong acidity, and the skin It has been desired to find effectiveness in Furthermore, the effectiveness for the skin was confirmed, and application to an external preparation for skin was desired.
本発明者らは、皮膚外用剤への梅肉エキス配合を可能とするべく鋭意検討を行った結果、梅肉エキスの水溶性部分を取り出し、活性炭にまず吸着させ、水性アルコールを用いることによって、活性炭に吸着した成分を抽出することによって、着色・匂いが少なく、不溶分及びクエン酸等の酸が少なく、ムメフラールの含有比率が高い活性炭処理梅肉エキスを製造できることを見出し、その抽出液に保湿効果が見られ、更に、その他の保湿剤と併用することによって保湿効果が向上することを見出し、本発明を完成した。 As a result of intensive studies to enable the ume meat extract to be incorporated into the skin external preparation, the present inventors have taken out the water-soluble part of the ume meat extract, first adsorbed on activated carbon, and using aqueous alcohol, By extracting the components adsorbed on the activated carbon, we found that it is possible to produce an activated carbon-treated plum extract with a low content of scent, odor, acid such as citric acid and high content of umefural, and moisturizing the extract. The present invention was completed by finding that the effect was seen and that the moisturizing effect was improved by using it together with other moisturizing agents.
即ち、本発明は、活性炭処理梅肉エキスと保湿剤を含有する皮膚外用剤を提供するものである。 That is, this invention provides the skin external preparation containing an activated carbon treatment ume meat extract and a moisturizer.
本発明の活性炭処理梅肉エキスは、着色が少なく、酸度が低いため処方系への影響が少ない。そして、保湿性に優れた皮膚外用剤を提供することができる。更に、他の保湿剤と併用することによって、更に優れた保湿性効果が期待できる。 The activated carbon-treated plum meat extract of the present invention is less colored and has a low acidity and therefore has little effect on the prescription system. And the skin external preparation excellent in moisture retention can be provided. Furthermore, by using together with other moisturizing agents, a further excellent moisturizing effect can be expected.
本発明皮膚外用剤の成分である活性炭処理梅肉エキスは、既に食品への利用が検討され、クエン酸濃度を低減させたものが造られている。クエン酸を低減した梅肉エキスは、例えば次の方法により製造することができる。 The activated carbon-treated plum meat extract, which is a component of the external preparation for skin of the present invention, has already been studied for use in foods and has been produced with a reduced citric acid concentration. The plum extract with reduced citric acid can be produced, for example, by the following method.
即ち、市販の梅肉エキスに精製水を加え、よく分散後、遠心分離またはろ過を行い、梅肉エキス水抽出液を得る。次いで、活性炭を加え、しばらく放置後、ろ過を行い、活性炭をる。活性炭を集め、５０%エタノールで抽出を行い、活性炭処理梅肉エキスを得ることができる。 That is, purified water is added to a commercially available ume meat extract, and after well dispersing, centrifugation or filtration is performed to obtain an extract solution of ume meat extract. Next, activated carbon is added, and after standing for a while, filtration is performed to obtain activated carbon. Activated carbon is collected and extracted with 50% ethanol to obtain an activated carbon-treated plum meat extract.
本発明皮膚外用剤における活性炭処理梅肉エキスの含有量は、好ましくは乾燥固形分として０.０００１〜１０重量％（以下単に「％」で示す）であり、より好ましくは０.０１〜５％である。 抽出液を使用する場合は、溶質である乾燥固形分の含有量が上記範囲内であれば、その抽出液濃度等は何ら限定されるものではない。
この活性炭処理梅肉エキスの含有量が０.０００１％より少ないと十分な効果が得られないことがあり、また、１０％を越えて配合してもそれ以上の効果の増大は見られない。
The content of the activated carbon-treated plum meat extract in the skin external preparation of the present invention is preferably 0.0001 to 10% by weight (hereinafter simply referred to as “%”) as a dry solid content, and more preferably 0.01 to 5%. It is. In the case of using an extract, the concentration of the extract is not limited as long as the content of dry solid content as a solute is within the above range.
If the content of this activated carbon-treated plum extract is less than 0.0001%, a sufficient effect may not be obtained, and even if it exceeds 10%, no further increase in effect is observed.
一方、併用される保湿剤としては、アミノ酸、ポリオールまたはムコ多糖類が挙げられる。 On the other hand, the humectant used in combination includes an amino acid, a polyol or a mucopolysaccharide.
更に詳しくは、アミノ酸は、セリン、プロリン、ヒドロキシプロリン、スレオニン、メチオニン、グリシン、システイン、アスパラギン酸、アルギニン、オルニチンなどが挙げられる。 More specifically, examples of amino acids include serine, proline, hydroxyproline, threonine, methionine, glycine, cysteine, aspartic acid, arginine, ornithine and the like.
ポリオールは、グリセリン、1,3-ブチレングリコール、ジグリセリンが挙げられる。 Examples of the polyol include glycerin, 1,3-butylene glycol, and diglycerin.
ムコ多糖類は、ヒアルロン酸、コンドロイチン硫酸、デルマタン硫酸、ヘパラン硫酸、ヘパリン及びケラタン硫酸並びにこれらの塩類が挙げられる。 Examples of the mucopolysaccharide include hyaluronic acid, chondroitin sulfate, dermatan sulfate, heparan sulfate, heparin and keratan sulfate, and salts thereof.
上記の併用成分である保湿剤の本発明の皮膚外用剤への配合量は、保湿剤の種類により相違するが、以下に示す範囲とすることが好ましい。 The blending amount of the moisturizing agent, which is the above-mentioned combination component, into the external preparation for skin of the present invention varies depending on the type of moisturizing agent, but is preferably in the following range.
更にまた、保湿剤であるアミノ酸及び／又はポリオール及び／又はムコ多糖類の本発明皮膚外用剤中の配合量は、アミノ酸及び／又はムコ多糖に関しては、一般には０.０００１％〜５％、好ましくは０.００１〜１％である。 これらの含有量が０.０００１％より少ない場合は、十分な効果が得られないことがあり、また、５％を超えて配合してもそれ以上の効果の増大は見られない。ポリオールに関しては、一般には０．１％〜２０％、好ましくは１〜５％である。
これらの含有量が０．１％より少ない場合は、十分な効果が得られないことがあり、また、２０％を超えて配合してもそれ以上の効果の増大は見られないばかりか、皮膚刺激となる場合もある。
Furthermore, the amount of the moisturizing amino acid and / or polyol and / or mucopolysaccharide in the skin external preparation of the present invention is generally 0.0001% to 5%, preferably about amino acid and / or mucopolysaccharide. Is 0.001 to 1%. When these contents are less than 0.0001%, a sufficient effect may not be obtained, and even when the content exceeds 5%, no further increase in the effect is observed. Regarding the polyol, it is generally 0.1% to 20%, preferably 1 to 5%.
When these contents are less than 0.1%, a sufficient effect may not be obtained, and even if the content exceeds 20%, no further increase in the effect is observed, and the skin It can be a stimulus.
本発明の皮膚外用剤は、常法に従い、必須成分である活性炭処理梅肉エキスと保湿剤とを通常の皮膚外用剤として知られる種々の形態の基剤に配合して調製することができる。 The skin external preparation of the present invention can be prepared by blending the activated carbon-treated plum meat extract and the humectant, which are essential components, with various forms of bases known as normal skin external preparations according to a conventional method.
皮膚外用剤の形態の例としては、特に限定されず、例えば、乳液、クリーム、化粧水、パック、分散液、洗浄料等の化粧品や、軟膏剤、クリーム剤、外用液剤等の医薬品などとすることができ、外用剤の基剤としては、これら外用剤の形態に応じた基剤、例えば、精製水、低級アルコール、多価アルコール、油脂、界面活性剤、紫外線吸収剤、増粘剤、色素、防腐剤、香料等を用いることができる。 Examples of the form of the external preparation for skin are not particularly limited, and include, for example, cosmetics such as emulsions, creams, lotions, packs, dispersions, cleaning agents, and pharmaceuticals such as ointments, creams, and external preparations. As a base for external preparations, bases according to the form of these external preparations, for example, purified water, lower alcohols, polyhydric alcohols, oils and fats, surfactants, ultraviolet absorbers, thickeners, dyes Preservatives, fragrances and the like can be used.
次に参考例及び実施例を挙げて本発明を更に詳細に説明するが、本発明はこれらになんら制約されるものではない。 Next, although a reference example and an Example are given and this invention is demonstrated in detail, this invention is not restrict | limited at all to these.
〔製造例１〕活性炭処理梅肉エキスの製造方法
市販の梅肉エキス（梅丹製）１５０ｇに精製水５０００ｍＬを加え、よく分散後、ろ過を行い、梅肉エキス水抽出液を得た。抽出液５０００ｍＬに活性炭（太閤FC）を液量に対して０．５%にあたる２５ｇを加え、時々攪拌し１５分間放置した。ろ過を行い、未吸着液を捨て、次いで、ろ過残分（活性炭）に１５００ｍLの水で洗浄した。ろ過残分（活性炭）に、５０%エタノール５０００ｍＬ順次加え、溶出を行った。溶出液を減圧下溶媒の除去を行い、最終凍結乾燥を行い、約９ｇの活性炭処理梅肉エキスを得る。
[Production Example 1] Method for producing activated carbon-treated ume meat extract To 150 g of commercially available ume meat extract (made by Umedan), 5000 mL of purified water was added and well dispersed, followed by filtration to obtain an extract of ume meat extract. To 5000 mL of the extract, 25 g of activated carbon (Dazai FC) corresponding to 0.5% of the liquid amount was added, and stirred occasionally and left for 15 minutes. Filtration was performed, the unadsorbed liquid was discarded, and then the filtration residue (activated carbon) was washed with 1500 mL of water. To the filtration residue (activated carbon), 5000 mL of 50% ethanol was sequentially added for elution. The solvent is removed from the eluate under reduced pressure, and final lyophilization is performed to obtain about 9 g of activated carbon-treated plum meat extract.
〔実験例１〕活性炭処理梅肉エキス単独での保湿効果
試料として活性炭処理梅肉及びグリセリンの25％水溶液を作成し，約0.10gを正確にφ=25mmのガラスフィルターをセットした容器に滴下した。人工的に設定した温度30℃，２Lの密閉容器中で０％（シリカゲル），約40%（K2CO3），約80%（（NH4）2SO4）において試料を放置した。経時的にそれぞれの試料の重量変化を測定し，減少分を水分の蒸散として，水分残存率を求めた。測定は，同一試料につき３検体ずつ行い平均した。
[Experimental example 1] Moisturizing effect of activated charcoal-treated ume meat extract alone A 25% aqueous solution of activated charcoal-treated ume meat and glycerin was prepared as a sample, and about 0.10 g was dropped into a container in which a glass filter of φ = 25 mm was accurately set. . Samples were left at 0% (silica gel), about 40% (K 2 CO 3 ), and about 80% ((NH 4 ) 2 SO 4 ) in an artificially set temperature of 30 ° C in a 2 L sealed container. The change in the weight of each sample over time was measured, and the remaining amount of water was calculated using the decrease as the transpiration of water. The measurement was performed by averaging three samples for the same sample.
図１、２、３から分かるように、本試験法で高い保湿作用を示すグリセリンと比較して、勝ってはいないが、それに迫る保湿作用を有することが分かった。 As can be seen from FIGS. 1, 2, and 3, it was found that the present test method has a moisturizing effect approaching that of glycerin, which is not as good as glycerin, which exhibits a high moisturizing effect.
〔実験例２〕他の保湿剤と組み合わせた実使用における保湿効果
実施例１〜３及び比較例１〜４ 化粧水表１に示す組成化粧水を調製し、その保湿実感及び皮膚状態を評価した。
（評価方法）２６〜５２才の女性４２名をパネルとし、各６名を１群として、毎日朝と夜の２回、８週間にわたって洗顔後に被験化粧水の適量を顔面に塗布した。塗布による保湿実感及び皮膚状態を下の評価基準によって評価した。６名の評価の平均値を表２に示す。
[Experimental Example 2] Moisturizing effect in actual use in combination with other moisturizing agents Examples 1 to 3 and Comparative Examples 1 to 4 Skin lotions Composition lotions shown in Table 1 were prepared and their moisturizing feeling and skin condition were evaluated.
(Evaluation method) 42 women aged 26 to 52 years old were used as panels, and each group of 6 people was applied as a group to the face with an appropriate amount of the test skin lotion every day for 8 weeks. The moisturizing feeling and skin condition by application were evaluated according to the following evaluation criteria. Table 2 shows the average values of the evaluations of six people.
保湿実感スコア：
［スコア］ ［ 状 態 ］
１ 保湿感が低い。
２ 保湿感やや低い。
３ 中程度の保湿感。
４ 保湿感がやや高い。
５ 保湿感が高く。
Moisturizing feeling score:
[Score] [State]
1 Low moisturizing feeling.
2 Moisturizing feeling is slightly low.
3 Medium moisturizing feeling.
4 Moisturizing feeling is slightly high.
5 High moisturizing feeling.
肌状態スコア：
［スコア］ ［ 状 態 ］
１ 肌の皮溝が不鮮明であり、角質のはがれが認められる。
２ 肌の皮溝がやや不鮮明であるかまたは一方向性が強い。
３ 肌の皮溝は認められるが、浅いかまたは一方向性が強い。
４ 肌の皮溝が認められるかまたはやや網目状である。
５ 肌の皮溝がはっきり認められるかまたはきれいな網目状である。
Skin condition score:
[Score] [State]
1 Skin gaps are unclear and exfoliation of the skin is observed.
2 The skin groove is slightly unclear or strong in one direction.
3 Skin crevices are observed, but shallow or unidirectional.
4 Skin crevices are observed or are somewhat reticulated.
5 Skin gaps are clearly visible or have a fine mesh.
表２のように従来の保湿剤単独及び活性炭処理梅肉エキス単独よりも保湿剤と活性炭処理梅肉エキスを併用した化粧水を塗布した群の方が、保湿実感及び肌状態の評価ともに優れていた。 As shown in Table 2, both the moisturizing effect and skin condition evaluation were superior in the group applied with lotion containing a moisturizer and activated carbon-treated plum extract, compared to conventional moisturizer and activated carbon-treated plum extract alone. It was.
本発明の活性炭処理梅肉エキスを配合した皮膚外用剤は、活性炭処理梅肉エキス自体の着色が少なく、酸度の低いため処方系への影響が少ないため、種々の剤型に応用ができる。そして、保湿性に優れているため、広く化粧料に応用が期待できる。 The topical skin preparation containing the activated carbon-treated ume meat extract of the present invention has little coloration of the activated carbon-treated ume meat extract itself and has a low acidity and therefore has little influence on the prescription system, and therefore can be applied to various dosage forms. And since it is excellent in moisture retention, it can be widely applied to cosmetics.
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| JPH11228561A (en) * | 1998-02-13 | 1999-08-24 | Natl Food Res Inst | Hydroxymethyl furfural derivative and its use |
| JP2005289940A (en) * | 2004-04-05 | 2005-10-20 | Hiroko Ito | Free radical scavenger |
| JP2006061032A (en) * | 2004-08-25 | 2006-03-09 | Irie Shoji | Method for producing ume flesh extract |
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| JPH11228561A (en) * | 1998-02-13 | 1999-08-24 | Natl Food Res Inst | Hydroxymethyl furfural derivative and its use |
| JP2005289940A (en) * | 2004-04-05 | 2005-10-20 | Hiroko Ito | Free radical scavenger |
| JP2006061032A (en) * | 2004-08-25 | 2006-03-09 | Irie Shoji | Method for producing ume flesh extract |
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