JP4612417B2 - 眼の遺伝子治療 - Google Patents

眼の遺伝子治療 Download PDF

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Publication number
JP4612417B2
JP4612417B2 JP2004532124A JP2004532124A JP4612417B2 JP 4612417 B2 JP4612417 B2 JP 4612417B2 JP 2004532124 A JP2004532124 A JP 2004532124A JP 2004532124 A JP2004532124 A JP 2004532124A JP 4612417 B2 JP4612417 B2 JP 4612417B2
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JP
Japan
Prior art keywords
endostatin
pharmaceutical composition
individual
vector
formulated
Prior art date
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Expired - Fee Related
Application number
JP2004532124A
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English (en)
Japanese (ja)
Other versions
JP2006516112A5 (https=
JP2006516112A (ja
Inventor
ピーター アンソニー カンポチアロ，
マイケル カレコ，
Original Assignee
ノバルティス アーゲー
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Filing date
Publication date
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Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2006516112A publication Critical patent/JP2006516112A/ja
Publication of JP2006516112A5 publication Critical patent/JP2006516112A5/ja
Application granted granted Critical
Publication of JP4612417B2 publication Critical patent/JP4612417B2/ja
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts or implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2004532124A 2002-08-28 2003-08-27 眼の遺伝子治療 Expired - Fee Related JP4612417B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40647002P 2002-08-28 2002-08-28
PCT/EP2003/009497 WO2004020469A2 (en) 2002-08-28 2003-08-27 Ocular gene therapy

Publications (3)

Publication Number Publication Date
JP2006516112A JP2006516112A (ja) 2006-06-22
JP2006516112A5 JP2006516112A5 (https=) 2010-06-24
JP4612417B2 true JP4612417B2 (ja) 2011-01-12

Family

ID=31978303

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004532124A Expired - Fee Related JP4612417B2 (ja) 2002-08-28 2003-08-27 眼の遺伝子治療

Country Status (11)

Country Link
US (1) US20070104684A1 (https=)
EP (1) EP1534751B1 (https=)
JP (1) JP4612417B2 (https=)
CN (2) CN100526332C (https=)
AT (1) ATE464321T1 (https=)
AU (1) AU2003258675B2 (https=)
CA (1) CA2496820A1 (https=)
DE (1) DE60332122D1 (https=)
IL (1) IL166950A (https=)
NZ (1) NZ538958A (https=)
WO (1) WO2004020469A2 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100475270C (zh) * 2006-01-20 2009-04-08 清华大学 一种治疗肿瘤的药物及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6174861B1 (en) 1996-10-22 2001-01-16 The Children's Medical Center Corporation Methods of inhibiting angiogenesis via increasing in vivo concentrations of endostatin protein
CA2304983A1 (en) * 1997-09-24 1999-04-01 The Regents Of The University Of California Non-primate lentiviral vectors and packaging systems
US6106826A (en) * 1997-12-17 2000-08-22 Wisconsin Alumni Research Foundation Replication competent, avirulent Herpes simplex virus as a vector for neural and ocular gene therapy
US6670321B1 (en) * 1998-12-30 2003-12-30 The Children's Medical Center Corporation Prevention and treatment for retinal ischemia and edema
US6267954B1 (en) * 1999-11-24 2001-07-31 Universite De Paris V Rene-Descartes Intraocular transplantation of encapsulated cells
WO2001083729A2 (en) * 2000-05-01 2001-11-08 Novartis Ag Vectors for ocular transduction and use thereof for genetic therapy
AU2001272932A1 (en) * 2000-06-02 2001-12-17 Entremed, Inc Angiostatin and endostatin binding proteins and methods of use
AU2002224403A1 (en) * 2000-10-13 2002-04-22 Entremed, Inc Endostatin and pitslre protein kinases as angiogenesis-inhibiting peptides and method of use
EP1401480B1 (en) * 2001-02-22 2012-11-28 Novartis AG Viral vectors encoding endostatin in the treatment of ocular neovascularization
JP2005533485A (ja) * 2002-02-04 2005-11-10 ノバルティス アクチエンゲゼルシャフト 組換えウシ免疫不全ウイルスに基づく遺伝子導入システム
AU2003226349B2 (en) * 2002-04-11 2008-01-31 Children's Medical Center Corporation Methods for inhibiting vascular hyperpermeability
AU2003277910A1 (en) * 2002-09-27 2004-04-19 Novartis Ag Ocular gene therapy

Also Published As

Publication number Publication date
CN1708513A (zh) 2005-12-14
WO2004020469A3 (en) 2004-04-29
IL166950A (en) 2011-04-28
CA2496820A1 (en) 2004-03-11
ATE464321T1 (de) 2010-04-15
AU2003258675B2 (en) 2009-03-26
US20070104684A1 (en) 2007-05-10
DE60332122D1 (de) 2010-05-27
CN100526332C (zh) 2009-08-12
JP2006516112A (ja) 2006-06-22
WO2004020469A2 (en) 2004-03-11
AU2003258675A1 (en) 2004-03-19
EP1534751B1 (en) 2010-04-14
HK1077306A1 (en) 2006-02-10
EP1534751A2 (en) 2005-06-01
NZ538958A (en) 2006-09-29
CN101637611A (zh) 2010-02-03

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