JP4591245B2 - Laser diffraction / scattering particle size distribution analyzer - Google Patents
Laser diffraction / scattering particle size distribution analyzer Download PDFInfo
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- JP4591245B2 JP4591245B2 JP2005201597A JP2005201597A JP4591245B2 JP 4591245 B2 JP4591245 B2 JP 4591245B2 JP 2005201597 A JP2005201597 A JP 2005201597A JP 2005201597 A JP2005201597 A JP 2005201597A JP 4591245 B2 JP4591245 B2 JP 4591245B2
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- 239000007788 liquid Substances 0.000 claims description 53
- 239000011261 inert gas Substances 0.000 claims description 38
- 238000005259 measurement Methods 0.000 claims description 14
- 230000000903 blocking effect Effects 0.000 claims description 7
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 238000009792 diffusion process Methods 0.000 claims 1
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- 239000000523 sample Substances 0.000 description 35
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- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 230000003287 optical effect Effects 0.000 description 4
- 210000005056 cell body Anatomy 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
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- 238000001514 detection method Methods 0.000 description 2
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 238000013019 agitation Methods 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 238000012937 correction Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000007561 laser diffraction method Methods 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
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- 238000003908 quality control method Methods 0.000 description 1
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Description
本発明は、レーザ回折・散乱式粒度分布測定装置に関し、更に詳しくは試料液を空気に接触させずに測定可能なレーザ回折・散乱式粒度分布測定装置に関する。 The present invention relates to a laser diffraction / scattering particle size distribution measuring apparatus, and more particularly to a laser diffraction / scattering particle size distribution measuring apparatus capable of measuring a sample liquid without contacting it with air.
被測定粒子を分散させた媒液中の粒子の粒度分布を測定する測定装置の一つに、レーザ回折・散乱式粒度分布測定装置がある。この測定装置は、媒液中に被測定粒子を分散させた試料液を収容したセルにレーザ光を照射し、試料液中の被測定粒子群によって回折および散乱されたレーザ光をリングディテクタなどの光検出器によって検出し、粒度分布を求めるものである。 One of measuring devices for measuring the particle size distribution of particles in a liquid medium in which particles to be measured are dispersed is a laser diffraction / scattering particle size distribution measuring device. This measuring apparatus irradiates a cell containing a sample liquid in which particles to be measured are dispersed in a liquid medium with laser light, and diffracts and scatters the laser light diffracted by the particles to be measured in the sample liquid, such as a ring detector. The particle size distribution is obtained by detection with a photodetector.
すなわち、図５にこの種の測定装置の基本的な構成を模式的に示すように、測定対象となるセル１７内の試料液中の被測定粒子群Ｐに、レーザ光源１１からのレーザ光をコリメータ１２等を介して平行光束にして照射すると、レーザ光は被測定粒子群Ｐによって回折または散乱し、空間的な光強度分布パターンが生ずる。この回折・散乱光（以下、単に散乱光と称する）のうち、前方への散乱光は集光レンズ１３によって集光され、その焦点距離の位置にある検出面にリング状の散乱像を結ぶ。この前方への散乱光強度パターンは、互いに半径の異なるリング状の受光面を有する複数の光センサ素子を同心状に配置してなるリングディテクタ（前方散乱光センサ）１４によって検出される。また、側方および後方への散乱光は、側方散乱光センサ１５および後方散乱光センサ１６によってそれぞれ検出される。 That is, as schematically shown in FIG. 5 of the basic configuration of this type of measuring apparatus, the laser light from the laser light source 11 is applied to the measured particle group P in the sample liquid in the cell 17 to be measured. When irradiated as a parallel light beam through the collimator 12 or the like, the laser light is diffracted or scattered by the particle group P to be measured, and a spatial light intensity distribution pattern is generated. Of this diffracted / scattered light (hereinafter simply referred to as scattered light), the forward scattered light is collected by the condenser lens 13 and forms a ring-shaped scattered image on the detection surface located at the focal length. This forward scattered light intensity pattern is detected by a ring detector (forward scattered light sensor) 14 formed by concentrically arranging a plurality of optical sensor elements having ring-shaped light receiving surfaces having different radii. Side scattered light and backward scattered light are detected by the side scattered light sensor 15 and the back scattered light sensor 16, respectively.
このようにして測定部における複数の光センサにより測定された散乱光の空間強度分布パターンは、通常Ａ−Ｄ変換器によりディジタル化されて散乱光強度分布データとなってコンピュータに取り込まれる。そして得られた回折および散乱光の強度分布を、公知のフラウンホーファの回折理論ないしミーの散乱理論に基づいて演算処理を行い、サンプル粒子の粒度分布を求めている。 The spatial intensity distribution pattern of the scattered light measured by the plurality of optical sensors in the measurement unit in this manner is usually digitized by an A / D converter and taken into a computer as scattered light intensity distribution data. The intensity distribution of the obtained diffraction and scattered light is subjected to arithmetic processing based on the known Fraunhofer diffraction theory or Mie scattering theory to obtain the particle size distribution of the sample particles.
上記レーザ回折・散乱式粒度分布測定装置で試料を収容するのに用いられるセル１７は、フローセルと回分セルとに大別することができる。このうち、フローセルはセル１７に入口側および出口側の外部流路を接続して、外部流路上に設けたポンプを駆動することによってセル１７内に試料液を供給あるいは循環させるものである。このフローセルの場合には、セル１７内に試料液が強制的に供給、排出されるので、セル１７内に試料液を連続的に一定容量供給（循環）することができるだけの試料液量が必要となる。 The cell 17 used to store the sample in the laser diffraction / scattering particle size distribution measuring apparatus can be roughly classified into a flow cell and a batch cell. Among these, the flow cell connects an external flow path on the inlet side and the outlet side to the cell 17 and drives or feeds a sample solution into the cell 17 by driving a pump provided on the external flow path. In the case of this flow cell, the sample solution is forcibly supplied to and discharged from the cell 17, so that a sample solution amount that can supply (circulate) a constant volume of sample solution into the cell 17 is necessary. It becomes.
一方、回分セルは試料液を外部から連続的に供給するのではなく、セル１７内に一定容量の試料液を貯留した状態で測定を行う。したがって回分セルの場合は、セル容量程度の少量の試料液で測定することができる。例えば特許文献１にはフローセルを用いた例が記載され、特許文献２には回分セルを用いた例が記載されている。
On the other hand, the batch cell does not continuously supply the sample liquid from the outside, but performs measurement in a state where a predetermined volume of the sample liquid is stored in the cell 17. Therefore, in the case of a batch cell, measurement can be performed with a small amount of sample solution having a cell capacity. For example, Patent Document 1 describes an example using a flow cell, and
このレーザ回折・散乱法による粒度分布測定方式は、測定可能な粒径範囲が非常に広く、測定時間も短い上に、再現性にも優れていることなどから、粉体（粒子群）を原料や製品とする食料品・医薬品など各種の分野において、研究段階にある新規開発の評価や、製品の品質管理に汎用されている。 This particle size distribution measurement method using the laser diffraction / scattering method has a very wide measurable particle size range, a short measurement time, and excellent reproducibility. In various fields such as foods and pharmaceuticals used as products, it is widely used for evaluation of new development in the research stage and product quality control.
従来、レーザ回折・散乱式粒度分布測定装置を用いて試料液中の被測定粒子群の散乱光強度パターンの測定、すなわち湿式測定を行う場合、試料液を収容するのに一般にフローセルまたは回分セルが用いられているが、被測定粒子群自体もしくは被測定粒子群を分散させた試料液が空気に触れると粒子の形状変化を伴うような反応を起こす場合、どちらのセルを用いても試料液と空気が接触してしまうために、得られた測定結果は実際の粒子分布になるとは限らず、正確な評価・判定を行うことができないという問題がある。
本発明は、このような事情に鑑みてなされたものであって、被測定粒子群を分散した試料液を空気に接触させずに測定可能なレーザ回折・散乱式粒度分布測定装置を提供することを目的とする。
Conventionally, when measuring a scattered light intensity pattern of a group of particles to be measured in a sample liquid using a laser diffraction / scattering type particle size distribution measuring apparatus, that is, when performing wet measurement, a flow cell or a batch cell is generally used to contain the sample liquid. However, if the sample particle itself or the sample liquid in which the particle group to be measured is dispersed comes into contact with the air and causes a reaction that changes the shape of the particles, Since the air comes into contact, the obtained measurement result is not always an actual particle distribution, and there is a problem that accurate evaluation / determination cannot be performed.
The present invention has been made in view of such circumstances, and provides a laser diffraction / scattering particle size distribution measuring apparatus capable of measuring a sample liquid in which a group of particles to be measured is dispersed without contacting the air. With the goal.
上記課題を解決するため、本発明は、被測定粒子群を媒液中に分散させた試料液にレーザ光を照射して得られる回折・散乱光の空間強度分布をリングディテクタを含む検出器により測定し、その測定データから被測定粒子群の粒度分布をミーの散乱理論ないしはフラウンホーファの回折理論に基づいて算出するレーザ回折・散乱式粒度分布測定装置において、試料液を収容する回分セルであって不活性ガス導入口と不活性ガス排気口が形成された回分セルを備え、測定時には前記不活性ガス導入口から不活性ガスを試料液上部の空間部に導入し、その不活性ガスを前記不活性ガス排気口から排気するよう流すことで試料液を空気から遮断する空気遮断手段を備えていることを特徴とする。
そして、前記回分セルは、試料液を収容する回分セル本体と、その回分セル本体に一体的に固着もしくは取外し可能に装着する試料液供給口を設けたセルキャップと、前記試料液供給口を開閉可能に覆うセルカバーにて構成し、前記不活性ガス導入口と前記不活性ガス排気口は前記セルカバーに設けるようにすることが好適である。
In order to solve the above problems, the present invention uses a detector including a ring detector to determine the spatial intensity distribution of diffraction / scattered light obtained by irradiating a sample liquid in which a group of particles to be measured are dispersed in a liquid medium. In a laser diffraction / scattering type particle size distribution measuring device that measures and calculates the particle size distribution of a group of particles to be measured based on Mie's scattering theory or Fraunhofer's diffraction theory from the measurement data, it is a batch cell that contains a sample liquid. A batch cell having an inert gas inlet and an inert gas outlet is provided. During measurement, an inert gas is introduced from the inert gas inlet into the space above the sample liquid, and the inert gas is introduced into the inert gas. An air blocking means for blocking the sample solution from the air by flowing the exhaust gas through the active gas exhaust port is provided .
The batch cell includes a batch cell main body for containing the sample liquid, a cell cap provided with a sample liquid supply port that is integrally fixed to or removable from the batch cell main body , and opens and closes the sample liquid supply port. It is preferable that the cell cover is configured to be covered , and the inert gas introduction port and the inert gas exhaust port are provided in the cell cover .
本発明のレーザ回折・散乱式粒度分布測定装置は、回分セル内に不活性ガスを充填することで試料液と空気との間に層をつくるので、空気に触れることによる被測定粒子（サンプル）の状態変化を防止することができる。これにより、測定誤差を生じさせないで測定精度の高く安定した測定が可能になる。 The laser diffraction / scattering type particle size distribution measuring apparatus of the present invention forms a layer between a sample liquid and air by filling an inert gas in a batch cell, so that a particle to be measured (sample) by touching the air It is possible to prevent a change in state. This enables stable measurement with high measurement accuracy without causing measurement errors.
本発明が提供するレーザ回折・散乱式粒度分布測定装置は次のような特徴を有している。第１の特徴は媒液中に分散させた被測定粒子群にレーザ光を照射して得られる回折・散乱光の空間強度分布を測定し、その測定データから被測定粒子群の粒度分布を算出するレーザ回折・散乱式粒度分布測定装置において、不活性ガスを導入して媒液および媒液中の被測定粒子を空気から遮断する空気遮断手段を具備した回分セルを備えた点にあり、第２の特徴は前記空気遮断手段を、試料液を収容する回分セル本体に一体的に固着もしくは取外し可能に装着する試料液供給口を設けたセルキャップと、前記試料液供給口を開閉するセルカバーにて構成されている点にあり、第３の特徴は前記セルカバーには不活性ガスを導入する不活性ガス導入口と不活性ガスを排気する不活性ガス排気口が形成されている点である。
したがって最良の形態の基本的な構成はこれら上記第１の特徴を備えた構成と、第２の特徴を備えた構成と、第３の特徴を具備するレーザ回折・散乱式粒度分布測定装置である。
The laser diffraction / scattering particle size distribution measuring apparatus provided by the present invention has the following characteristics. The first feature is to measure the spatial intensity distribution of the diffracted / scattered light obtained by irradiating the measured particle group dispersed in the liquid medium with laser light, and calculate the particle size distribution of the measured particle group from the measured data. The laser diffraction / scattering type particle size distribution measuring apparatus includes a batch cell equipped with an air blocking means for blocking the medium and particles to be measured in the medium from air by introducing an inert gas. The second feature is that a cell cap provided with a sample liquid supply port for attaching the air blocking means to a batch cell main body containing the sample liquid so as to be integrally fixed or removable, and a cell cover for opening and closing the sample liquid supply port The third feature is that the cell cover is formed with an inert gas inlet for introducing an inert gas and an inert gas outlet for exhausting the inert gas. is there.
Therefore, the basic configuration of the best mode is a configuration having the first feature, a configuration having the second feature, and a laser diffraction / scattering particle size distribution measuring device having the third feature. .
以下、図面を参照しつつ本発明の実施例の形態について述べる。図１は本発明のレーザ回折・散乱式粒度分布測定装置に使用される回分セルを斜め上方向から見た斜視図、図２は回分セルの構成を示す正面図（Ａ）とそのＡ−Ａ断面図（Ｂ）である。本レーザ回折・散乱式粒度分布測定装置は、空気遮断状態で媒液および被測定粒子を注入する注入手段と、空気遮断状態で媒液中の被測定粒子を攪拌する攪拌手段を備えており、回分セル１は、被測定粒子群Ｐを分散させた媒液、すなわち試料液を収容する内空間を形成した例えば石英ガラス製の回分セル本体２と、該回分セル本体２に接着等による一体的固着もしくは取外し可能に装着され、被測定粒子群Ｐおよび媒液を注入するための試料液供給口３ａを開口したセルキャップ３と、前記試料液供給口３ａを開閉するためのセルカバー４と、前記回分セル本体２内の試料液を攪拌する攪拌棒５から構成されている。
Hereinafter, embodiments of the present invention will be described with reference to the drawings. FIG. 1 is a perspective view of a batch cell used in the laser diffraction / scattering particle size distribution measuring apparatus of the present invention as viewed obliquely from above, and FIG. 2 is a front view (A) showing the configuration of the batch cell and its AA. It is sectional drawing (B). The laser diffraction / scattering type particle size distribution measuring apparatus includes an injection unit that injects the liquid medium and the particles to be measured in an air-blocked state, and an agitation unit that stirs the particles to be measured in the liquid medium in an air-blocked state. The batch cell 1 is composed of, for example, a batch cell
前記セルキャップ３の長手方向の両外側面に側溝３ｂ、前記セルカバー４の両内側面に前記側溝３ｂに嵌合する突起部４ａが形成されており、突起部４ａを側溝３ｂに嵌合させてセルカバー４をセルキャップ３上をスライドさせることにより前記試料液供給口３ａが開閉される。また前記セルカバー４の上面には前記攪拌棒５を通す長孔４ｂが形成され、窒素ガスなどの不活性ガスを導入する不活性ガス導入口（以後、ガス導入口と称す）４ｃ及び不活性ガス排気口（以後、ガス排気口と称す）４ｄが設けられている。このガス排気口４ｄには、不活性ガスあるいは試料液の揮発成分を含んだ不活性ガスの測定装置内での漏れを防ぐために外部排気用のチューブ（図示省略）が接続されている。また、前記攪拌棒５の下部先端には攪拌プレート５ａが直交する方向に固着されており、モータ(図示省略)等により攪拌棒５を上下方向に移動させることにより攪拌プレート５ａで試料液が攪拌される。
図３は回分セル１の上面図で媒液注入時の状態（Ａ）と測定時（Ｂ）の状態を示すものである。媒液を注入するには図３（Ａ）に示すように前記セルカバー４を図における左方にスライドして長孔４ｂから媒液を注入する。注入完了後、セルカバー４を右方に移動して図３（Ｂ）に示すように長孔４ｂを閉じ、不活性ガスをガス導入口４ｃより回分セル本体２内に充填する。そして回分セル１内に不活性ガスが充填されたところで、媒液注入時のようにセルカバー４を少し左にスライドし、長孔４ｂから注射器等を用いて被測定粒子群Ｐを含んだ懸濁液を注入し、セルカバー４を閉じてモータ(図示省略)を駆動することにより、攪拌棒５を上下方向に移動させて攪拌し、媒液中に被測定粒子を分散させる。
FIG. 3 is a top view of the batch cell 1 and shows a state (A) at the time of liquid injection and a state (B) at the time of measurement. In order to inject the liquid medium, as shown in FIG. 3A, the cell cover 4 is slid leftward in the figure to inject the liquid medium from the
図４は、本レーザ回折・散乱式粒度分布測定装置の光学系の構成と電気的構成を模式的に表した構成図である。半導体レーザ等を用いたレーザ光源１１の出力光は、集光レンズ１２ａ、空間フィルタ１２ｂおよびコリメータ１２からなる照射光学系により平行光束に成形された後、回分セル１に照射される。 FIG. 4 is a configuration diagram schematically showing the configuration and electrical configuration of the optical system of the laser diffraction / scattering particle size distribution measuring apparatus. The output light of the laser light source 11 using a semiconductor laser or the like is formed into a parallel light beam by an irradiation optical system including the condenser lens 12a, the spatial filter 12b, and the collimator 12, and then irradiated to the batch cell 1.
前記回分セル１には媒液中に被測定粒子群Ｐを分散させた試料液が充填されるとともに、試料液上部の空間部には例えば窒素ガスなどの不活性ガスボンベ２２から２ｃｃ／ｍｉｎ程度の不活性ガス２１が供給され、試料液と外部空気との接触は不活性ガス２１により遮断される。 The batch cell 1 is filled with a sample liquid in which the particle group P to be measured is dispersed in a liquid medium, and the space above the sample liquid is about 2 cc / min from an inert gas cylinder 22 such as nitrogen gas. The inert gas 21 is supplied, and the contact between the sample liquid and the external air is blocked by the inert gas 21.
レーザ光の照射によって被測定粒子群Ｐから生じる回折・散乱光のうち、前方散乱光はリングディテクタ１４、９０°方向は側方散乱光センサ１５、それ以上は後方散乱光センサ１６によって検出される。これらの各センサ群からの出力は、それぞれに対応するアンプ、アンプ出力を切り替えるマルチプレクサおよびＡ−Ｄ変換器からなるデータサンプリング回路１８を介して増幅およびディジタル化された後、回折・散乱強度分布データとしてコンピュータ１９に取り込まれる。 Of the diffracted / scattered light generated from the particle group P to be measured by laser light irradiation, the forward scattered light is detected by the ring detector 14, the 90 ° direction is detected by the side scattered light sensor 15, and the further scattered light is detected by the back scattered light sensor 16. . The output from each of these sensor groups is amplified and digitized via a data sampling circuit 18 comprising an amplifier corresponding to each sensor, a multiplexer for switching the amplifier output, and an A-D converter, and then the diffraction / scattering intensity distribution data. As a computer 19.
前記コンピュータ１９は、ＣＰＵ、ＲＯＭ、ＲＡＭ等を主体として構成されており、公知の手法であるミーの散乱理論ないしはフラウンホーファ回折理論に基づく演算を行うためのプログラムのほか集光レンズ１３の収差と光路上での減衰に起因する誤差の補正を行うためのプログラム等が書き込まれており、これらの補正が行われた上で回折・散乱光強度分布データから被測定粒子群Ｐの粒度分布へ変換するための演算が行われる。その結果は、コンピュータ１９に表示され、あるいはプリンタ２０にプリントアウトされる。 The computer 19 is composed mainly of a CPU, a ROM, a RAM, and the like. In addition to a program for performing calculations based on the Mie scattering theory or Fraunhofer diffraction theory, which are well-known methods, the aberration and light of the condenser lens 13 are calculated. A program for correcting an error caused by attenuation on the road is written, and after these corrections are performed, the diffraction / scattered light intensity distribution data is converted to the particle size distribution of the particle group P to be measured. The operation for this is performed. The result is displayed on the computer 19 or printed out on the printer 20.
本発明は、上記実施例に示すように回分セル１内に不活性ガスを充填させることにより、不活性ガスと空気との間に層を形成して測定対象となる被測定粒子群Ｐを含む試料液と空気との接触を無くするようにしたものでその構成は上記実施例に限定されるものではなく、例えばガス導入口４ｃおよびガス排気口４ｄをセルキャップ３側に設けるようにしてもよい。 The present invention includes a measured particle group P to be measured by forming a layer between an inert gas and air by filling the batch cell 1 with an inert gas as shown in the above embodiment. The contact between the sample liquid and air is eliminated, and the configuration is not limited to the above embodiment. For example, the gas inlet 4c and the gas outlet 4d may be provided on the cell cap 3 side. Good.
本発明はレーザ回折・散乱式の粒度分布測定装置に利用される。 The present invention is used in a laser diffraction / scattering type particle size distribution measuring apparatus.
１ 回分セル
２ 回分セル本体
３ セルキャップ
３ａ 試料液供給口
３ｂ 側溝
４ セルカバー
４ａ 突起部
４ｂ 長孔
４ｃ 不活性ガス導入口（ガス導入口）
４ｄ 不活性ガス排気口（ガス排気口）
５ 攪拌棒
５ａ 攪拌プレート
１１ レーザ光源
１２ コリメータ
１２ａ 集光レンズ
１２ｂ 空間フィルタ
１３ 集光レンズ
１４ リングディテクタ
１５ 側方散乱光センサ
１６ 後方散乱光センサ
１７ セル
１８ データサンプリング回路
１９ コンピュータ
２０ プリンタ
２１ 不活性ガス
２２ 不活性ガスボンベ
Ｐ 被測定粒子群
1
4d Inert gas exhaust port (gas exhaust port)
5 Stirring bar 5a Stirring plate 11 Laser light source 12 Collimator 12a Condensing lens 12b Spatial filter 13 Condensing lens 14 Ring detector 15 Side scattered light sensor 16 Back scattered light sensor 17 Cell 18 Data sampling circuit 19 Computer 20 Printer 21 Inert gas 22 Inert gas cylinder P Particles to be measured
Claims (2)
試料液を収容する回分セルであって不活性ガス導入口と不活性ガス排気口が形成された回分セルを備え、測定時には前記不活性ガス導入口から不活性ガスを試料液上部の空間部に導入し、その不活性ガスを前記不活性ガス排気口から排気するよう流すことで試料液を空気から遮断する空気遮断手段を備えていることを特徴とするレーザ回折・散乱式粒度分布測定装置。 The spatial intensity distribution of the diffracted / scattered light obtained by irradiating the sample liquid with the measured particle group dispersed in the medium is measured by a detector including a ring detector, and the measured particle group is obtained from the measured data. In a laser diffraction / scattering type particle size distribution measuring device that calculates the particle size distribution of a particle based on Mie's scattering theory or Fraunhofer's diffraction theory ,
A batch cell for storing a sample liquid, which is provided with a batch cell formed with an inert gas inlet and an inert gas outlet. During measurement, the inert gas is introduced into the space above the sample liquid from the inert gas inlet. introduced, a laser diffraction and diffusion particle size distribution measuring apparatus, characterized in that the sample liquid e Bei air blocking means for blocking the air flowing to the exhaust the inert gas from the inert gas outlet.
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Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6165138A (en) * | 1984-09-07 | 1986-04-03 | Olympus Optical Co Ltd | Optical reaction testing cell |
| JPH01213548A (en) * | 1988-02-22 | 1989-08-28 | Shimadzu Corp | Preparation of dispersion medium liquid for measuring grain size distribution |
| JPH02124447A (en) * | 1988-11-02 | 1990-05-11 | Dan Kagaku:Kk | Light scattering type grain counter for reactive gas |
| JPH0331744A (en) * | 1989-06-29 | 1991-02-12 | Shimadzu Corp | Instrument for measuring adsorbed quantity |
| JPH06174724A (en) * | 1992-12-04 | 1994-06-24 | Kowa Co | Immunologically measuring apparatus |
| JPH07198722A (en) * | 1993-12-28 | 1995-08-01 | Tokuyama Corp | Reagent for immunological agglutination reaction and its carrier |
| JP2501938Y2 (en) * | 1990-12-28 | 1996-06-19 | 株式会社島津製作所 | Particle size distribution measuring device |
| JP2001133385A (en) * | 1999-11-05 | 2001-05-18 | Shimadzu Corp | Laser diffraction/scatter type particle-size distribution measuring device |
-
2005
- 2005-07-11 JP JP2005201597A patent/JP4591245B2/en active Active
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6165138A (en) * | 1984-09-07 | 1986-04-03 | Olympus Optical Co Ltd | Optical reaction testing cell |
| JPH01213548A (en) * | 1988-02-22 | 1989-08-28 | Shimadzu Corp | Preparation of dispersion medium liquid for measuring grain size distribution |
| JPH02124447A (en) * | 1988-11-02 | 1990-05-11 | Dan Kagaku:Kk | Light scattering type grain counter for reactive gas |
| JPH0331744A (en) * | 1989-06-29 | 1991-02-12 | Shimadzu Corp | Instrument for measuring adsorbed quantity |
| JP2501938Y2 (en) * | 1990-12-28 | 1996-06-19 | 株式会社島津製作所 | Particle size distribution measuring device |
| JPH06174724A (en) * | 1992-12-04 | 1994-06-24 | Kowa Co | Immunologically measuring apparatus |
| JPH07198722A (en) * | 1993-12-28 | 1995-08-01 | Tokuyama Corp | Reagent for immunological agglutination reaction and its carrier |
| JP2001133385A (en) * | 1999-11-05 | 2001-05-18 | Shimadzu Corp | Laser diffraction/scatter type particle-size distribution measuring device |
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