JP4560081B2 - 薬剤の計時投薬の改良された方法 - Google Patents
薬剤の計時投薬の改良された方法 Download PDFInfo
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- JP4560081B2 JP4560081B2 JP2007501157A JP2007501157A JP4560081B2 JP 4560081 B2 JP4560081 B2 JP 4560081B2 JP 2007501157 A JP2007501157 A JP 2007501157A JP 2007501157 A JP2007501157 A JP 2007501157A JP 4560081 B2 JP4560081 B2 JP 4560081B2
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
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- A—HUMAN NECESSITIES
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- A61M15/00—Inhalators
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- A61M15/0083—Timers
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- G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
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- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
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- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/01—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes specially adapted for anaesthetising
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
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- Heart & Thoracic Surgery (AREA)
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- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
1) 投与すべき薬剤の特定物質用パラメータ(102)。典型的な特定物質用パラメータは、例えば、親油性、ヒト血清アルブミンに対する結合定数及び/又は他の血漿たんぱく質に対する結合定数、非結合血漿分画、水緩衝液又は腸液内の溶解度、分子の大きさ(分子量又は分子容で表現)、肝クリアランス及び/又は腎クリアランス、例えば、人工又は生物学的膜をまたぐ透過係数と血漿(血液)と種々の器官の間の平衡分配係数等の物理化学パラメータである。
2) 問題の患者の特徴を示す特定種用の生理学的、解剖学的、生化学的及び/又は遺伝学的入力パラメータ(103)。これらの型式のパラメータは、特に、体重、全身体積に対する個々の器官の体積成分、個々の器官の血流速度、個々の器官の水、脂肪及び脂質成分と、代謝活性酵素(特に肝臓と腸内の)の発現及び機能又は細胞膜を通る分子の活性輸送のためのたんぱく質の発現及び機能を特徴付けるパラメータを含む。これらのパラメータが、直接測定されるか、又は、年齢、性別、体重と除脂肪体重等の容易に決定できる患者パラメータで特定の母集団に対して相関付けられる(P.S. Price, R.B. Conolly, C.F. Chaisson, E.A. Gross, J.S. Young, E.T. Mathis, D.R. Tedder「ヒトのPBPKモデルで使用される生理学的因子の相互間変動のモデリング」Crit. Rev. Toxicol. 33, 469-503 (2003))。これらの間の個々のパラメータ又はいくつかのパラメータは、本発明の方法で使用してもよい。
3) 時間の関数として投与された投与量を記載する投薬プロファイル(104)。
以下のことも指定される。
4) 血漿、血液又は直接、目標器官の生化学目標において投与すべき薬剤の意図する濃度−時間プロファイル、又は意図する効果−時間プロファイル("SETPOINT"プロファイル105)。この目標プロファイルは、特定徴候用であると共に、問題の薬剤に依存する。多くの医療的に関連する場合、例えば、麻酔薬の投与において、最大限に急勾配の矩形の効果プロファイルが望ましい、即ち、意図する効果(ここでは、麻酔)が起こり、次に、所定の時間に渡りできるだけ一定に保たれて、次に、処置の最後に再び急激に落下するべきである。時間プロファイルは時間Z(t)の単純な関数であるか、又は、公差範囲が交互に又は更に指定されてもよい(最大値Zmax(t)と最小値Zmin(t)の間の間隔として定義される)。
102 特定物質用入力パラメータ
103 患者データ
104 投薬時間プロファイル
105 "SETPOINT"プロファイル
106 "ACTUAL"プロファイル
Claims (1)
- 時間の関数として薬剤を制御投薬するように、投薬装置を制御する方法において、
指定手段が、所望の濃度−時間プロファイル又は所望の効果−時間プロファイルを示す、適応依存及び物質依存目標プロファイルを指定するステップa)と、シュミレーション手段が、治療すべき個人の身体の解剖学的、生理学的及び/又は遺伝学的パラメータと、投与すべき薬剤の特定物質用入力パラメータとに基づいて、時間変動投与プロファイルによる生理学ベースの薬物動態及び/又は薬力学シュミレーションをするステップb)と、適合手段が、シュミレートされた時間プロファイルが所定の目標プロファイルと一致するまで、投与プロファイルを反復数値適合するステップc)と、制御手段が、ステップc)の結果に基づいて投薬装置を制御するステップd)とを備える方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200410010516 DE102004010516A1 (de) | 2004-03-04 | 2004-03-04 | Verbessertes Verfahren zur zeitlichen Dosierung von Arzneistoffen |
PCT/EP2005/001745 WO2005084731A2 (de) | 2004-03-04 | 2005-02-19 | Verbessertes verfahren zur zeitlichen dosierung von arzneistoffen |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007526051A JP2007526051A (ja) | 2007-09-13 |
JP2007526051A5 JP2007526051A5 (ja) | 2007-11-29 |
JP4560081B2 true JP4560081B2 (ja) | 2010-10-13 |
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Application Number | Title | Priority Date | Filing Date |
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JP2007501157A Active JP4560081B2 (ja) | 2004-03-04 | 2005-02-19 | 薬剤の計時投薬の改良された方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9095653B2 (ja) |
EP (1) | EP1722839B1 (ja) |
JP (1) | JP4560081B2 (ja) |
AU (1) | AU2005218736B2 (ja) |
CA (1) | CA2558452C (ja) |
DE (1) | DE102004010516A1 (ja) |
DK (1) | DK1722839T3 (ja) |
ES (1) | ES2443651T3 (ja) |
WO (1) | WO2005084731A2 (ja) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005028080A1 (de) * | 2005-06-17 | 2006-12-21 | Bayer Technology Services Gmbh | Verfahren zur zeitlich gesteuerten intravenösen Verabreichung des Narkosemittels Propofol |
US8163270B2 (en) * | 2006-04-25 | 2012-04-24 | Huntington Medical Research Institutes | Methods of diagnosing and treating migraine |
DE102006028232A1 (de) * | 2006-06-20 | 2007-12-27 | Bayer Technology Services Gmbh | Vorrichtung und Verfahren zur Berechnung und Bereitstellung einer Medikamentendosis |
WO2008064134A2 (en) * | 2006-11-17 | 2008-05-29 | Aardex Ltd. | Medication dosing monitor |
JP5227189B2 (ja) * | 2006-12-27 | 2013-07-03 | 株式会社根本杏林堂 | 薬液注入装置および薬液注入方法 |
WO2008099356A2 (en) * | 2007-02-15 | 2008-08-21 | Koninklijke Philips Electronics N.V. | Drug delivery device |
CA3058773C (en) * | 2010-01-04 | 2023-08-08 | Craig L. Hocum | Erythropoietic stimulating agent (esa) dosage determination |
WO2014173558A1 (en) | 2013-04-24 | 2014-10-30 | Fresenius Kabi Deutschland Gmbh | Method of operating a control device for controlling an infusion device |
DE102014105058A1 (de) * | 2014-04-09 | 2015-10-15 | Stephanie Ittstein | Vorrichtung zu einer Herstellung und/oder zu einer Verabreichung |
US10478544B2 (en) * | 2014-09-25 | 2019-11-19 | Nxstage Medical, Inc. | Medicament preparation and treatment devices, methods, and systems |
US10534895B2 (en) * | 2015-01-20 | 2020-01-14 | Icpd Technologies, Llc | System and method for ranking options for medical treatments |
US11227680B2 (en) * | 2015-01-20 | 2022-01-18 | Prxcision Llc | System and method for ranking options for medical treatments |
JP7091240B2 (ja) | 2015-09-25 | 2022-06-27 | シー・アール・バード・インコーポレーテッド | モニタリング能力を含むカテーテルアセンブリ |
EA201892347A1 (ru) | 2016-04-15 | 2019-04-30 | Баксалта Инкорпорейтед | Способ и устройство для предоставления фармакокинетической схемы дозирования лекарственных препаратов |
WO2018012246A1 (ja) * | 2016-07-12 | 2018-01-18 | 国立大学法人熊本大学 | 薬物動態解析方法、薬物動態解析装置及びプログラム |
US10896749B2 (en) | 2017-01-27 | 2021-01-19 | Shire Human Genetic Therapies, Inc. | Drug monitoring tool |
EP3349217B1 (de) * | 2017-09-20 | 2021-06-30 | Siemens Healthcare GmbH | Verfahren und datenverarbeitungseinheit zum ermitteln eines patientenspezifischen pharmakokinetischen parameters |
JP2023509521A (ja) | 2020-01-07 | 2023-03-08 | バード・アクセス・システムズ,インコーポレーテッド | 感温血管デバイスを含む診断システムおよび方法 |
CO2022007433A1 (es) | 2022-05-29 | 2022-06-30 | Bioin Soluciones S A S | Sistema y método implementado por computador para control de fluidos anestésicos mediante control fuzzy |
Family Cites Families (16)
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US4533346A (en) * | 1979-06-26 | 1985-08-06 | Pharmacontrol Corporation | System for automatic feedback-controlled administration of drugs |
US5597377A (en) * | 1994-05-06 | 1997-01-28 | Trustees Of Boston University | Coronary sinus reperfusion catheter |
US5687208A (en) * | 1995-10-06 | 1997-11-11 | Bhb General Partnership | Method of and apparatus for predicting computed tomography contrast enhancement with feedback |
AU714270B2 (en) * | 1995-10-24 | 1999-12-23 | Gruenenthal Gmbh | Method of inhibiting sleep apnea |
US5944680A (en) * | 1996-06-26 | 1999-08-31 | Medtronic, Inc. | Respiratory effort detection method and apparatus |
WO2000001434A1 (en) * | 1998-07-07 | 2000-01-13 | The University Of Sheffield | Inhalers |
HUP0300333A3 (en) * | 1999-05-11 | 2009-01-28 | Ortho Mcneil Pharm Inc | Pharmacokinetic and pharmacodynamic modeling of erythropoietin administration |
DE20005004U1 (de) * | 2000-03-17 | 2000-06-08 | Braun Melsungen Ag | Narkoseregler |
US6599281B1 (en) * | 2000-05-03 | 2003-07-29 | Aspect Medical Systems, Inc. | System and method for adaptive drug delivery |
JP4812225B2 (ja) * | 2000-07-11 | 2011-11-09 | 塩野義製薬株式会社 | 生理活性ペプチド含有腸溶性製剤 |
US6631291B2 (en) * | 2001-05-18 | 2003-10-07 | Instrumentarium Corp. | Closed loop drug administration method and apparatus using EEG complexity for control purposes |
US20050010193A1 (en) * | 2002-05-06 | 2005-01-13 | Laurent Philippe E. | Novel methods for administration of drugs and devices useful thereof |
DE10160270A1 (de) | 2001-12-07 | 2003-06-26 | Bayer Ag | Computersystem und Verfahren zur Berechnung von ADME-Eigenschaften |
DE10345837A1 (de) | 2003-10-02 | 2005-04-21 | Bayer Technology Services Gmbh | Verfahren zur Bestimmung einer Wirkstoffdosierung |
DE10345836A1 (de) | 2003-10-02 | 2005-04-21 | Bayer Technology Services Gmbh | Verfahren zur Simulation der Wechselwirkung von chemischen Substanzen mit lebenden Organismen |
DE102005028080A1 (de) * | 2005-06-17 | 2006-12-21 | Bayer Technology Services Gmbh | Verfahren zur zeitlich gesteuerten intravenösen Verabreichung des Narkosemittels Propofol |
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2004
- 2004-03-04 DE DE200410010516 patent/DE102004010516A1/de not_active Withdrawn
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2005
- 2005-02-19 JP JP2007501157A patent/JP4560081B2/ja active Active
- 2005-02-19 US US10/598,416 patent/US9095653B2/en active Active
- 2005-02-19 WO PCT/EP2005/001745 patent/WO2005084731A2/de active Application Filing
- 2005-02-19 EP EP05715413.0A patent/EP1722839B1/de active Active
- 2005-02-19 DK DK05715413.0T patent/DK1722839T3/en active
- 2005-02-19 ES ES05715413.0T patent/ES2443651T3/es active Active
- 2005-02-19 CA CA2558452A patent/CA2558452C/en active Active
- 2005-02-19 AU AU2005218736A patent/AU2005218736B2/en active Active
Also Published As
Publication number | Publication date |
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ES2443651T3 (es) | 2014-02-20 |
AU2005218736B2 (en) | 2011-09-08 |
DE102004010516A1 (de) | 2005-09-22 |
EP1722839A1 (de) | 2006-11-22 |
AU2005218736A1 (en) | 2005-09-15 |
JP2007526051A (ja) | 2007-09-13 |
CA2558452C (en) | 2013-04-23 |
EP1722839B1 (de) | 2013-12-11 |
US20070196479A1 (en) | 2007-08-23 |
WO2005084731A2 (de) | 2005-09-15 |
US9095653B2 (en) | 2015-08-04 |
DK1722839T3 (en) | 2014-02-17 |
CA2558452A1 (en) | 2005-09-15 |
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