JP2007526051A - 薬剤の計時投薬の改良された方法 - Google Patents
薬剤の計時投薬の改良された方法 Download PDFInfo
- Publication number
- JP2007526051A JP2007526051A JP2007501157A JP2007501157A JP2007526051A JP 2007526051 A JP2007526051 A JP 2007526051A JP 2007501157 A JP2007501157 A JP 2007501157A JP 2007501157 A JP2007501157 A JP 2007501157A JP 2007526051 A JP2007526051 A JP 2007526051A
- Authority
- JP
- Japan
- Prior art keywords
- profile
- administration
- time
- dosing
- parameters
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/168—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body
- A61M5/172—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic
- A61M5/1723—Means for controlling media flow to the body or for metering media to the body, e.g. drip meters, counters ; Monitoring media flow to the body electrical or electronic using feedback of body parameters, e.g. blood-sugar, pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/0065—Inhalators with dosage or measuring devices
- A61M15/0068—Indicating or counting the number of dispensed doses or of remaining doses
- A61M15/0083—Timers
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B45/00—ICT specially adapted for bioinformatics-related data visualisation, e.g. displaying of maps or networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
- G16B5/30—Dynamic-time models
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H20/00—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance
- G16H20/10—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients
- G16H20/17—ICT specially adapted for therapies or health-improving plans, e.g. for handling prescriptions, for steering therapy or for monitoring patient compliance relating to drugs or medications, e.g. for ensuring correct administration to patients delivered via infusion or injection
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/50—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for simulation or modelling of medical disorders
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H50/00—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics
- G16H50/70—ICT specially adapted for medical diagnosis, medical simulation or medical data mining; ICT specially adapted for detecting, monitoring or modelling epidemics or pandemics for mining of medical data, e.g. analysing previous cases of other patients
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16H—HEALTHCARE INFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR THE HANDLING OR PROCESSING OF MEDICAL OR HEALTHCARE DATA
- G16H70/00—ICT specially adapted for the handling or processing of medical references
- G16H70/40—ICT specially adapted for the handling or processing of medical references relating to drugs, e.g. their side effects or intended usage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/01—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes specially adapted for anaesthetising
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
- A61M5/142—Pressure infusion, e.g. using pumps
- A61M2005/14208—Pressure infusion, e.g. using pumps with a programmable infusion control system, characterised by the infusion program
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Primary Health Care (AREA)
- Data Mining & Analysis (AREA)
- Biophysics (AREA)
- Evolutionary Biology (AREA)
- Biotechnology (AREA)
- Theoretical Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Databases & Information Systems (AREA)
- Pathology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Pharmacology & Pharmacy (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
1) 投与すべき薬剤の特定物質用パラメータ(102)。典型的な特定物質用パラメータは、例えば、親油性、ヒト血清アルブミンに対する結合定数及び/又は他の血漿たんぱく質に対する結合定数、非結合血漿分画、水緩衝液又は腸液内の溶解度、分子の大きさ(分子量又は分子容で表現)、肝クリアランス及び/又は腎クリアランス、例えば、人工又は生物学的膜をまたぐ透過係数と血漿(血液)と種々の器官の間の平衡分配係数等の物理化学パラメータである。
2) 問題の患者の特徴を示す特定種用の生理学的、解剖学的、生化学的及び/又は遺伝学的入力パラメータ(103)。これらの型式のパラメータは、特に、体重、全身体積に対する個々の器官の体積成分、個々の器官の血流速度、個々の器官の水、脂肪及び脂質成分と、代謝活性酵素(特に肝臓と腸内の)の発現及び機能又は細胞膜を通る分子の活性輸送のためのたんぱく質の発現及び機能を特徴付けるパラメータを含む。これらのパラメータが、直接測定されるか、又は、年齢、性別、体重と除脂肪体重等の容易に決定できる患者パラメータで特定の母集団に対して相関付けられる(P.S. Price, R.B. Conolly, C.F. Chaisson, E.A. Gross, J.S. Young, E.T. Mathis, D.R. Tedder「ヒトのPBPKモデルで使用される生理学的因子の相互間変動のモデリング」Crit. Rev. Toxicol. 33, 469-503 (2003))。これらの間の個々のパラメータ又はいくつかのパラメータは、本発明の方法で使用してもよい。
3) 時間の関数として投与された投与量を記載する投薬プロファイル(104)。
以下のことも指定される。
4) 血漿、血液又は直接、目標器官の生化学目標において投与すべき薬剤の意図する濃度−時間プロファイル、又は意図する効果−時間プロファイル("SETPOINT"プロファイル105)。この目標プロファイルは、特定徴候用であると共に、問題の薬剤に依存する。多くの医療的に関連する場合、例えば、麻酔薬の投与において、最大限に急勾配の矩形の効果プロファイルが望ましい、即ち、意図する効果(ここでは、麻酔)が起こり、次に、所定の時間に渡りできるだけ一定に保たれて、次に、処置の最後に再び急激に落下するべきである。時間プロファイルは時間Z(t)の単純な関数であるか、又は、公差範囲が交互に又は更に指定されてもよい(最大値Zmax(t)と最小値Zmin(t)の間の間隔として定義される)。
102 特定物質用入力パラメータ
103 患者データ
104 投薬時間プロファイル
105 "SETPOINT"プロファイル
106 "ACTUAL"プロファイル
Claims (10)
- 時間の関数として薬剤を制御投薬する方法において、
所望の濃度−時間プロファイル又は所望の効果−時間プロファイルを示す、適応依存及び物質依存目標プロファイルを指定するステップa)と、治療すべき個人の身体の解剖学的、生理学的及び/又は遺伝学的パラメータと、投与すべき薬剤の特定物質用入力パラメータとを考慮に入れて、時間変動投与プロファイルによる生理学ベースの薬物動態及び/又は薬力学シュミレーションをするステップb)と、シュミレートされた時間プロファイルが所定の目標プロファイルと一致するまで、投与プロファイルを反復数値適合するステップc)と、ステップc)の結果に基づいて投薬装置を制御するステップd)とを備える方法。 - 薬剤の投薬がヒト又は動物に実行される請求項1に記載の方法。
- 投与の型式が、以下の型式:静脈内投与、動脈内投与、腹膜内投与、筋肉内投与、皮下投与、局所投与、経口投与又は吸入投与の内のいずれかである請求項1に記載の方法。
- 考慮に入れるべき患者個人のパラメータが、以下:個々の器官の血流速度、体積と組成(水分、脂肪とプロテイン成分)、代謝活性酵素又は活性トランスポーターの遺伝子発現データから選択される請求項1に記載の方法。
- 考慮に入れるべき特定物質用パラメータが、以下の親油性、血漿プロテインに対する結合定数、遊離血漿分画、溶解度(水性系又は人工腸液における)、透過係数、モル質量、分子容、器官/結晶又は器官/血液分配係数から選択される請求項1に記載の方法。
- 投与プロファイルを適合する方法として、以下の数値最適化方法:特に準ニュートン法又はニュートン法における勾配法、ネスト間隔等の非勾配法とモンテカルロ法等の確率論的方法のいずれかが使用される請求項1に記載の方法。
- 投薬装置が、電子制御注入ポンプ、吸入器又は経口投与用の電子制御放出カプセルである請求項1に記載の方法。
- 解剖学的、生理学的及び/又は遺伝学的パラメータの1個以上が時間変動する請求項4に記載の方法。
- 解剖学的、生理学的及び/又は遺伝学的パラメータの1個以上が、投与中にリアルタイムで測定される請求項4に記載の方法。
- 治療の成功が、1個以上の適当な測定プローブによって追加的にオンラインで監視されると共に、投薬装置を制御するために、測定プローブの測定信号が共用される請求項1に記載の方法。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE200410010516 DE102004010516A1 (de) | 2004-03-04 | 2004-03-04 | Verbessertes Verfahren zur zeitlichen Dosierung von Arzneistoffen |
PCT/EP2005/001745 WO2005084731A2 (de) | 2004-03-04 | 2005-02-19 | Verbessertes verfahren zur zeitlichen dosierung von arzneistoffen |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2007526051A true JP2007526051A (ja) | 2007-09-13 |
JP2007526051A5 JP2007526051A5 (ja) | 2007-11-29 |
JP4560081B2 JP4560081B2 (ja) | 2010-10-13 |
Family
ID=34877345
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2007501157A Active JP4560081B2 (ja) | 2004-03-04 | 2005-02-19 | 薬剤の計時投薬の改良された方法 |
Country Status (9)
Country | Link |
---|---|
US (1) | US9095653B2 (ja) |
EP (1) | EP1722839B1 (ja) |
JP (1) | JP4560081B2 (ja) |
AU (1) | AU2005218736B2 (ja) |
CA (1) | CA2558452C (ja) |
DE (1) | DE102004010516A1 (ja) |
DK (1) | DK1722839T3 (ja) |
ES (1) | ES2443651T3 (ja) |
WO (1) | WO2005084731A2 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018012246A1 (ja) * | 2016-07-12 | 2018-01-18 | 国立大学法人熊本大学 | 薬物動態解析方法、薬物動態解析装置及びプログラム |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102005028080A1 (de) * | 2005-06-17 | 2006-12-21 | Bayer Technology Services Gmbh | Verfahren zur zeitlich gesteuerten intravenösen Verabreichung des Narkosemittels Propofol |
EP2013626A2 (en) * | 2006-04-25 | 2009-01-14 | Huntington Medical Research Institutes | Methods of diagnosing and treating migraine |
DE102006028232A1 (de) * | 2006-06-20 | 2007-12-27 | Bayer Technology Services Gmbh | Vorrichtung und Verfahren zur Berechnung und Bereitstellung einer Medikamentendosis |
WO2008064134A2 (en) * | 2006-11-17 | 2008-05-29 | Aardex Ltd. | Medication dosing monitor |
WO2008081830A1 (ja) * | 2006-12-27 | 2008-07-10 | Nemoto Kyorindo Co., Ltd. | 薬液注入装置および薬液注入方法 |
WO2008099356A2 (en) * | 2007-02-15 | 2008-08-21 | Koninklijke Philips Electronics N.V. | Drug delivery device |
AU2011203456B2 (en) | 2010-01-04 | 2014-07-31 | Mayo Foundation For Medical Education And Research | Erythropoietic Stimulating Agent (ESA) dosage determination |
WO2014173558A1 (en) | 2013-04-24 | 2014-10-30 | Fresenius Kabi Deutschland Gmbh | Method of operating a control device for controlling an infusion device |
DE102014105058A1 (de) * | 2014-04-09 | 2015-10-15 | Stephanie Ittstein | Vorrichtung zu einer Herstellung und/oder zu einer Verabreichung |
EP3197518B1 (en) * | 2014-09-25 | 2019-07-24 | NxStage Medical, Inc. | Medicament preparation and treatment devices and systems |
US10534895B2 (en) * | 2015-01-20 | 2020-01-14 | Icpd Technologies, Llc | System and method for ranking options for medical treatments |
US11227680B2 (en) * | 2015-01-20 | 2022-01-18 | Prxcision Llc | System and method for ranking options for medical treatments |
EP3346913A4 (en) | 2015-09-25 | 2019-01-16 | C.R. Bard Inc. | CATHETER ASSEMBLY COMPRISING MONITORING CAPABILITIES |
MY197302A (en) | 2016-04-15 | 2023-06-12 | Takeda Pharmaceuticals Co | Method and apparatus for providing a pharmacokinetic drug dosing regimen |
US10896749B2 (en) | 2017-01-27 | 2021-01-19 | Shire Human Genetic Therapies, Inc. | Drug monitoring tool |
EP3349217B1 (de) * | 2017-09-20 | 2021-06-30 | Siemens Healthcare GmbH | Verfahren und datenverarbeitungseinheit zum ermitteln eines patientenspezifischen pharmakokinetischen parameters |
JP2023509521A (ja) | 2020-01-07 | 2023-03-08 | バード・アクセス・システムズ,インコーポレーテッド | 感温血管デバイスを含む診断システムおよび方法 |
CO2022007433A1 (es) | 2022-05-29 | 2022-06-30 | Bioin Soluciones S A S | Sistema y método implementado por computador para control de fluidos anestésicos mediante control fuzzy |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4533346A (en) * | 1979-06-26 | 1985-08-06 | Pharmacontrol Corporation | System for automatic feedback-controlled administration of drugs |
US20020173729A1 (en) * | 2001-05-18 | 2002-11-21 | Hanna Viertio-Oja | Closed loop drug administration method and apparatus using eeg complexity for control purposes |
JP2003531691A (ja) * | 2000-05-03 | 2003-10-28 | アスペクト メディカル システムズ,インク. | 即応性薬物運搬システムと方法 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5597377A (en) * | 1994-05-06 | 1997-01-28 | Trustees Of Boston University | Coronary sinus reperfusion catheter |
US5687208A (en) * | 1995-10-06 | 1997-11-11 | Bhb General Partnership | Method of and apparatus for predicting computed tomography contrast enhancement with feedback |
DK0866711T3 (da) * | 1995-10-24 | 2006-11-27 | Gruenenthal Gmbh | Anvendelse af 6-methyl-5-oxo-3-thiomorpholinylcarbonyl-L-histidyl-L-prolinamid til fremstilling af et farmaceutisk præparat til modvirkning af sövnapnö |
US5944680A (en) * | 1996-06-26 | 1999-08-31 | Medtronic, Inc. | Respiratory effort detection method and apparatus |
AU747465B2 (en) * | 1998-07-07 | 2002-05-16 | University Of Sheffield, The | Inhalers |
BR0010316A (pt) * | 1999-05-11 | 2004-04-27 | Ortho Mcnell Pharmaceutical In | Método e sistema para obtenção de regimes de dosagem otimizados de epo para uma resposta farmacodinâmica/farmacocinética desejada em um paciente |
DE20005004U1 (de) * | 2000-03-17 | 2000-06-08 | B. Braun Melsungen Ag, 34212 Melsungen | Narkoseregler |
WO2002004016A1 (fr) * | 2000-07-11 | 2002-01-17 | Shionogi & Co., Ltd. | Preparations enteriques contenant des peptides physiologiquement actifs |
US20050010193A1 (en) * | 2002-05-06 | 2005-01-13 | Laurent Philippe E. | Novel methods for administration of drugs and devices useful thereof |
DE10160270A1 (de) | 2001-12-07 | 2003-06-26 | Bayer Ag | Computersystem und Verfahren zur Berechnung von ADME-Eigenschaften |
DE10345837A1 (de) | 2003-10-02 | 2005-04-21 | Bayer Technology Services Gmbh | Verfahren zur Bestimmung einer Wirkstoffdosierung |
DE10345836A1 (de) | 2003-10-02 | 2005-04-21 | Bayer Technology Services Gmbh | Verfahren zur Simulation der Wechselwirkung von chemischen Substanzen mit lebenden Organismen |
DE102005028080A1 (de) * | 2005-06-17 | 2006-12-21 | Bayer Technology Services Gmbh | Verfahren zur zeitlich gesteuerten intravenösen Verabreichung des Narkosemittels Propofol |
-
2004
- 2004-03-04 DE DE200410010516 patent/DE102004010516A1/de not_active Withdrawn
-
2005
- 2005-02-19 US US10/598,416 patent/US9095653B2/en active Active
- 2005-02-19 AU AU2005218736A patent/AU2005218736B2/en active Active
- 2005-02-19 EP EP05715413.0A patent/EP1722839B1/de active Active
- 2005-02-19 CA CA2558452A patent/CA2558452C/en active Active
- 2005-02-19 JP JP2007501157A patent/JP4560081B2/ja active Active
- 2005-02-19 ES ES05715413.0T patent/ES2443651T3/es active Active
- 2005-02-19 WO PCT/EP2005/001745 patent/WO2005084731A2/de active Application Filing
- 2005-02-19 DK DK05715413.0T patent/DK1722839T3/en active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4533346A (en) * | 1979-06-26 | 1985-08-06 | Pharmacontrol Corporation | System for automatic feedback-controlled administration of drugs |
JP2003531691A (ja) * | 2000-05-03 | 2003-10-28 | アスペクト メディカル システムズ,インク. | 即応性薬物運搬システムと方法 |
US20020173729A1 (en) * | 2001-05-18 | 2002-11-21 | Hanna Viertio-Oja | Closed loop drug administration method and apparatus using eeg complexity for control purposes |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018012246A1 (ja) * | 2016-07-12 | 2018-01-18 | 国立大学法人熊本大学 | 薬物動態解析方法、薬物動態解析装置及びプログラム |
Also Published As
Publication number | Publication date |
---|---|
AU2005218736A1 (en) | 2005-09-15 |
US20070196479A1 (en) | 2007-08-23 |
AU2005218736B2 (en) | 2011-09-08 |
DK1722839T3 (en) | 2014-02-17 |
EP1722839B1 (de) | 2013-12-11 |
CA2558452A1 (en) | 2005-09-15 |
DE102004010516A1 (de) | 2005-09-22 |
ES2443651T3 (es) | 2014-02-20 |
JP4560081B2 (ja) | 2010-10-13 |
WO2005084731A2 (de) | 2005-09-15 |
CA2558452C (en) | 2013-04-23 |
EP1722839A1 (de) | 2006-11-22 |
US9095653B2 (en) | 2015-08-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
JP4560081B2 (ja) | 薬剤の計時投薬の改良された方法 | |
AU2006257418B2 (en) | Device for the time-controlled intravenous administering of the anesthetic propofol | |
Cesarovic et al. | Isoflurane and sevoflurane provide equally effective anaesthesia in laboratory mice | |
LeSage et al. | Nicotine self-administration in the rat: effects of hypocretin antagonists and changes in hypocretin mRNA | |
España et al. | Circadian-dependent and circadian-independent behavioral actions of hypocretin/orexin | |
Beths et al. | Evaluation and optimisation of a targetcontrolled infusion system for administering propofol to dogs as part of a total intravenous anaesthetic technique during dental surgery | |
Reeves et al. | Early postnatal chronic intermittent hypoxia modifies hypoxic respiratory responses and long-term phrenic facilitation in adult rats | |
Teske et al. | Role of the locus coeruleus in enhanced orexin A-induced spontaneous physical activity in obesity-resistant rats | |
McCarren et al. | Assessing changes in volatile general anesthetic sensitivity of mice after local or systemic pharmacological intervention | |
Bellei et al. | The use of fentanyl‐patch in dogs undergoing spinal surgery: plasma concentration and analgesic efficacy | |
Loweth et al. | Inhibition of CaMKII in the nucleus accumbens shell decreases enhanced amphetamine intake in sensitized rats | |
Guo et al. | Dopamine transporter in the ventral tegmental area modulates recovery from propofol anesthesia in rats | |
Fonseca et al. | Orexin in the toad Rhinella schneideri: the location of orexinergic neurons and the role of orexin in ventilatory responses to hypercarbia and hypoxia | |
Rasys et al. | A systematic study of injectable anesthetic agents in the brown anole lizard (Anolis sagrei) | |
Wu et al. | Transcription factor ΔFosB acts within the nucleus of the solitary tract to increase mean arterial pressure during exposures to intermittent hypoxia | |
Sidorova et al. | Ecological and physiological assessment of animal anesthesia methods | |
Dimet et al. | A protocol for measuring cue reactivity in a rat model of cocaine use disorder | |
Karrenbauer et al. | Time-dependent effects of striatal interleukin-2 on open field behaviour in rats | |
Brandes et al. | REM sleep‐like episodes of motoneuronal depression and respiratory rate increase are triggered by pontine carbachol microinjections in in situ perfused rat brainstem preparation | |
Nakamura et al. | Intrathecal cocaine delivery enables long-access self-administration with binge-like behavior in mice | |
Kamerling et al. | Models for assessing the relationship between drug concentration and drug effect in performance horses | |
Rupniak et al. | Colorectal and bladder prokinetic activity of [Lys5, MeLeu9, Nle10]-NKA (4–10) after intranasal or sublingual delivery in dogs | |
Grahame et al. | Intravenous self‐administration of ethanol in mice | |
Revillo et al. | Odor-avoidance or odor-preference induced by amphetamine in the infant rat depending on the dose and testing modality | |
Khoo | The orexins and appetitive motivation in the rat |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071011 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071011 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20100209 |
|
A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100412 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100706 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100723 |
|
R150 | Certificate of patent or registration of utility model |
Ref document number: 4560081 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130730 Year of fee payment: 3 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130730 Year of fee payment: 3 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130730 Year of fee payment: 3 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313113 |
|
R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D02 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |