JP4491582B2 - 脳内血流測定デバイス - Google Patents
脳内血流測定デバイス Download PDFInfo
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- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6801—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be attached to or worn on the body surface
- A61B5/6813—Specially adapted to be attached to a specific body part
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- A61B5/0205—Simultaneously evaluating both cardiovascular conditions and different types of body conditions, e.g. heart and respiratory condition
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- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/40—Detecting, measuring or recording for evaluating the nervous system
- A61B5/4058—Detecting, measuring or recording for evaluating the nervous system for evaluating the central nervous system
- A61B5/4064—Evaluating the brain
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Description
Koizumi J, Yoshida Y, Nakazawa T, Ooneda G. Experimental studies of ischemicbrain edema, I: a new experimental model of cerebral embolism in rats in whichrecirculation can be introduced in the ischemic area. Jpn J Stroke. 1986;8:1-8 Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84-91 Schmid-Elsaesser R, Zausinger S, Hungerhuber E, Baethmann A, Reulen HJ. A critical reevaluation of the intraluminal thread model of focal cerebral ischemia: evidence of inadvertent premature reperfusion and subarachnoid hemorrhage in rats by laser-doppler flowmetory. Stroke. 1998;29:2162-70
血流計プローブを保持するプローブ保持部材を有して成り、脳内の血流を測定する際に、血流計プローブと共に用いるプローブ保持デバイスであって、
プローブ保持部材は、血流計プローブを保持した状態で、側頭骨に隣接してその外側に配置できることを特徴とするプローブ保持デバイスを提供する。
14,14’…プローブ保持部材、16…ブリッジ部分、
18,18’,20,20’…縁部、24,24’…導線、
26,26’…温度センサー、28,28’…導線、
30…光または音の照射および受容部、
32,32’,34,34’…開口部、
40…加熱要素配置領域(斜線部)、44…温度センサー。
上述の本発明のプローブ保持デバイスに血流計プローブを配置して血流測定デバイスを構成し、これを用いてラットのMCAOモデル実験を以下の要領で実施した。使用したデバイスは、図1および図2に示す保持デバイスであるが、1つのプローブ保持部材のみから成るものであった。即ち、血流計プローブ12およびプローブ保持部材14のみから構成されるものであった。尚、導線24を血流計に接続した。
イソフラン濃度5%の酸素を用いてラットを麻酔した。その後、気管挿入して30%の酸素および70%の窒素を含む混合ガスを用いて肺を人工呼吸させ、イソフランの呼気終末濃度を2.5%に下げた。表面加熱または冷却によって頭蓋周囲の温度を自動制御して37.0℃とした(モン・ア・サーム(Mon-a-therm)7000(マリンクロット社(Mallinckrodt Inc.)製)を使用)。ポリエチレンカテーテルを用いて尾骨動脈にカニュ−レを挿入した。後述のMCAOの間、動脈圧をモニターし、動脈血を間欠的にサンプリングして血液ガス、血糖値およびヘマトクリットをチェックした。
Zea-Longaらの方法に基づくMCAOのために全てのラットに手術を施した。手術用顕微鏡を使用して、中央線気管前切開(middle pretracheal incision)によって総頚動脈(CCA)を露出させた。そして、動脈から迷走神経および交感神経を注意して離した。総頚動脈の分岐点から脳側2mmの箇所で外頚動脈(ECA)を結紮した。内頚動脈を末梢側に剥離し翼口蓋動脈(PPA)の根部を露出させた。
右MCAの栄養領域であるの右脳の大脳皮質に関するMCAOの準備の前に、LDFの薄いプローブを配置した平坦な矩形シートである本発明の血流測定デバイスを、側頭筋と側頭骨との間に脳側に向かって超音波が照射されるように配置した。
全ての生理学的変量は、正常範囲内であった。実験を通じて2つのグループ間で血圧、動脈血ガスまたは血漿グルコース濃度に関して統計的に有意な相違は認められなかった。第1グループのラットの内、3匹は、MCAO後の48時間以内に死亡した(死亡率25%)。従って、これらのラットについては、組織病理学的な分析を実施しなかった。第2グループの全てのラットは、MCAO後48時間生存した。生存したラットについては、クモ膜下出血は認められなかったが、第1グループの死亡した3匹の内の2匹についてはクモ膜下出血が認められた。
図8に示すように、プローブ保持デバイス10のブリッジ部分16の領域40にジグザク状に線状の電気抵抗体を加熱要素として配置し、また、温度センサー44も配置し、これらをシリコーン樹脂で覆ってデバイスを得た。先と同様に、全身麻酔したラットの頭部の皮膚を切開して頭蓋骨を露出させ、側頭骨と側頭筋との間の両側のナチュラル・ポケットにプローブ保持部材を配置することによって、得られたデバイスをラットに取り付けた。
Claims (19)
- 血流計プローブを保持するプローブ保持部材を有して成り、脳内の血流を測定する際に、血流計プローブと共に用いるプローブ保持デバイスであって、プローブ保持部材は、血流計プローブを保持した状態で、側頭骨に隣接してその外側に配置できることを特徴とするプローブ保持デバイス。
- 2つのプローブ保持部材を有して成り、これらのプローブ保持部材を橋渡しして一体に保持するブリッジ部分を更に有して成る請求項1に記載のデバイス。
- プローブ保持部材およびブリッジ部分はそれぞれシート状形体であり、ブリッジ部分の各縁部に沿って各プローブ保持部材の縁部が一体に接続された状態に形成されている請求項1または2に記載のデバイス。
- デバイスは断面U字形状を有し、ブリッジ部分がU字の底部に対応し、プローブ保持部材はU字の底部の両端から上向きに延在する脚部に対応する請求項1〜3のいずれかに記載のデバイス。
- シート材料を屈曲することによって断面U字形状を有するようにした請求項1〜4のいずれかに記載のデバイス。
- プラスチック材料でできている請求項1〜5のいずれかに記載のデバイス。
- プローブ保持部材は、プローブを嵌め込むことができる、プローブの形状と相補的な凹部を有する請求項1〜6のいずれかに記載のデバイス。
- プローブ保持部材は、温度センサーをも保持できる請求項1〜7のいずれかに記載のデバイス。
- 血流計プローブは、レーザードップラー血流計のプローブである請求項1〜8のいずれかに記載のデバイス。
- 血流計プローブは、超音波ドップラー血流計のプローブである請求項1〜8のいずれかに記載のデバイス。
- プローブ保持部材は、側頭筋と側頭骨との間に配置できる寸法を有する請求項1〜10のいずれかに記載のデバイス。
- ラットまたはマウスの側頭筋と側頭骨との間に配置できる寸法を有する請求項1〜11のいずれかに記載のデバイス。
- ブリッジ部分は、加熱要素を更に有して成る、請求項2〜12のいずれかに記載のデバイス。
- (1)請求項1〜13のいずれかに記載のプローブ保持デバイス、および
(2)血流計プローブ
を有して成る、血流測定デバイス。 - 血流計プローブは、レーザードップラー血流計または超音波ドップラー血流計のプローブまたはである請求項14に記載の血流測定デバイス。
- プローブ保持部材は、温度センサーを更に有して成る請求項15に記載の血流測定デバイス。
- 請求項1〜13のいずれかに記載のプローブ保持デバイスに用いるプローブ保持部材の製造方法であって、
血流の測定を実施すべき動物の側頭筋と側頭骨との間に形成される空間に対応する原型を得、
得られた原型に基づいてプラスチック材料を成形することによってプローブ保持部材を得る
ことを特徴とする製造方法。 - 原型は、側頭筋と側頭骨との間に形成される空間に硬化性材料を注入して、その空間内で硬化性材料を硬化させることによって得る請求項17に記載の製造方法。
- 硬化性材料は、シリコーン樹脂である請求項18に記載の製造方法。
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PCT/JP2004/018364 WO2005055826A1 (ja) | 2003-12-12 | 2004-12-09 | 脳内血流測定デバイス |
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JP4726547B2 (ja) * | 2005-06-07 | 2011-07-20 | 株式会社 資生堂 | 肌性格の検査方法 |
WO2010041206A1 (en) * | 2008-10-07 | 2010-04-15 | Orsan Medical Technologies Ltd. | Diagnosis of acute strokes |
US9770360B2 (en) * | 2010-06-29 | 2017-09-26 | Renato Rozental | Therapeutic brain cooling system and spinal cord cooling system |
WO2016202955A1 (en) * | 2015-06-16 | 2016-12-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Detecting apparatus and associated imaging method |
EP3513714A4 (en) * | 2016-09-16 | 2020-05-27 | Alps Alpine Co., Ltd. | BIOMETRIC INFORMATION MEASURING DEVICE |
GB2557915B (en) * | 2016-12-16 | 2020-06-10 | Calderon Agudo Oscar | Method of and apparatus for non invasive medical imaging using waveform inversion |
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US4947853A (en) * | 1985-09-26 | 1990-08-14 | Hon Edward H | Sensor support base and method of application |
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WO1998030176A1 (en) * | 1997-01-08 | 1998-07-16 | Clynch Technologies, Inc. | Method for producing custom fitted medical devices |
US6743196B2 (en) * | 1999-03-01 | 2004-06-01 | Coaxia, Inc. | Partial aortic occlusion devices and methods for cerebral perfusion augmentation |
AU5659400A (en) * | 1999-09-21 | 2001-03-22 | Fisher & Paykel Healthcare Limited | Breathing assistance apparatus |
US6547737B2 (en) * | 2000-01-14 | 2003-04-15 | Philip Chidi Njemanze | Intelligent transcranial doppler probe |
US6421837B1 (en) * | 2001-09-06 | 2002-07-23 | Melinda Pearcy | Headband |
JP2003079626A (ja) * | 2001-09-10 | 2003-03-18 | Japan Science & Technology Corp | 超音波ドプラー法を応用した脳機能解析方法及びその脳機能解析システム |
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