JP4451059B2 - 分泌及び膜貫通ポリペプチドとそれをコードする核酸 - Google Patents

分泌及び膜貫通ポリペプチドとそれをコードする核酸 Download PDF

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Publication number
JP4451059B2
JP4451059B2 JP2002529483A JP2002529483A JP4451059B2 JP 4451059 B2 JP4451059 B2 JP 4451059B2 JP 2002529483 A JP2002529483 A JP 2002529483A JP 2002529483 A JP2002529483 A JP 2002529483A JP 4451059 B2 JP4451059 B2 JP 4451059B2
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JP
Japan
Prior art keywords
acid sequence
pro
amino acid
seq
antibody
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Expired - Lifetime
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JP2002529483A
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English (en)
Japanese (ja)
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JP2004526412A5 (enExample
JP2004526412A (ja
Inventor
ベーカー，ケビン，ピー．
イートン，ダン，エル．
フィルバロッフ，エレン
ゴッダード，オードリー
グリマルディ，ジェー．クリストファー
ガーニー，オースティン，エル．
スミス，ヴィクトリア
ステファン，ジーン−フィリップ
ワタナベ，コリン，ケー．
ウッド，ウィリアム，アイ．
チャン，ツオーミン
フォン，シャーマン
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ジェネンテック インコーポレイテッド
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Priority claimed from PCT/US2000/030873 external-priority patent/WO2001040465A2/en
Priority claimed from PCT/US2001/006520 external-priority patent/WO2001068848A2/en
Priority claimed from PCT/US2001/017092 external-priority patent/WO2001092331A2/en
Priority claimed from PCT/US2001/017800 external-priority patent/WO2001093983A1/en
Priority claimed from PCT/US2001/019692 external-priority patent/WO2002000690A2/en
Priority claimed from PCT/US2001/021066 external-priority patent/WO2002008288A2/en
Priority claimed from PCT/US2001/021735 external-priority patent/WO2002008284A2/en
Application filed by ジェネンテック インコーポレイテッド filed Critical ジェネンテック インコーポレイテッド
Publication of JP2004526412A publication Critical patent/JP2004526412A/ja
Publication of JP2004526412A5 publication Critical patent/JP2004526412A5/ja
Publication of JP4451059B2 publication Critical patent/JP4451059B2/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2002529483A 2000-09-01 2001-08-29 分泌及び膜貫通ポリペプチドとそれをコードする核酸 Expired - Lifetime JP4451059B2 (ja)

Applications Claiming Priority (23)

Application Number Priority Date Filing Date Title
US22989600P 2000-09-01 2000-09-01
US23062100P 2000-09-05 2000-09-05
US23514700P 2000-09-22 2000-09-22
PCT/US2000/030873 WO2001040465A2 (en) 1999-11-30 2000-11-10 Compositions and methods for the treatment of immune related diseases
US26187801P 2001-01-12 2001-01-12
US26191001P 2001-01-16 2001-01-16
US26215001P 2001-01-16 2001-01-16
US26193901P 2001-01-16 2001-01-16
US26439501P 2001-01-25 2001-01-25
US26642101P 2001-02-02 2001-02-02
US26762301P 2001-02-09 2001-02-09
PCT/US2001/006520 WO2001068848A2 (en) 2000-03-01 2001-02-28 Secreted and transmembrane polypeptides and nucleic acids encoding the same
US27439901P 2001-03-09 2001-03-09
US28098201P 2001-04-03 2001-04-03
US28219901P 2001-04-04 2001-04-04
US28212901P 2001-04-04 2001-04-04
US29058901P 2001-05-09 2001-05-09
PCT/US2001/017092 WO2001092331A2 (en) 2000-05-30 2001-05-25 Compositions and methods for the treatment of immune related diseases
PCT/US2001/017800 WO2001093983A1 (en) 2000-06-02 2001-06-01 Secreted and transmembrane polypeptides and nucleic acids encoding the same
PCT/US2001/019692 WO2002000690A2 (en) 2000-06-23 2001-06-20 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
PCT/US2001/021066 WO2002008288A2 (en) 2000-07-20 2001-06-29 Secreted and transmembrane polypeptides and nucleic acids encoding the same
PCT/US2001/021735 WO2002008284A2 (en) 2000-07-20 2001-07-09 Compositions and methods for the diagnosis and treatment of disorders involving angiogenesis
PCT/US2001/027099 WO2002024888A2 (en) 2000-09-01 2001-08-29 Secreted and transmembrane polypeptides and nucleic acids encoding the same

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2006024604A Division JP2006223304A (ja) 2000-09-01 2006-02-01 分泌及び膜貫通ポリペプチドとそれをコードする核酸

Publications (3)

Publication Number Publication Date
JP2004526412A JP2004526412A (ja) 2004-09-02
JP2004526412A5 JP2004526412A5 (enExample) 2010-01-28
JP4451059B2 true JP4451059B2 (ja) 2010-04-14

Family

ID=27585542

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2002529483A Expired - Lifetime JP4451059B2 (ja) 2000-09-01 2001-08-29 分泌及び膜貫通ポリペプチドとそれをコードする核酸
JP2006024604A Pending JP2006223304A (ja) 2000-09-01 2006-02-01 分泌及び膜貫通ポリペプチドとそれをコードする核酸

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2006024604A Pending JP2006223304A (ja) 2000-09-01 2006-02-01 分泌及び膜貫通ポリペプチドとそれをコードする核酸

Country Status (5)

Country Link
EP (1) EP1341814A2 (enExample)
JP (2) JP4451059B2 (enExample)
AU (2) AU2002216610A1 (enExample)
CA (2) CA2421056A1 (enExample)
WO (1) WO2002024888A2 (enExample)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6395511B1 (en) 1998-11-27 2002-05-28 Darwin Discovery, Ltd. Nucleic acids encoding a novel family of TGF-β binding proteins from humans
US20040009535A1 (en) 1998-11-27 2004-01-15 Celltech R&D, Inc. Compositions and methods for increasing bone mineralization
EP1686134A3 (en) * 1999-12-01 2006-08-09 Genentech, Inc. Secreted and transmembrane polypeptides and nucleic acids encoding the same
WO2001098491A2 (en) * 2000-06-19 2001-12-27 F. Hoffmann-La Roche Ag Osteolevin gene polymorphisms
US7268223B2 (en) 2000-09-22 2007-09-11 Wyeth Isolated nucleic acid molecules which encode a soluble IL-TIF receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof
US7094570B2 (en) 2003-03-11 2006-08-22 Ludwig Institute For Cancer Research Isolated nucleic acid molecules which encode a soluble IL-TIF/IL-22 receptor or binding protein which binds to IL-TIF/IL-22, and uses thereof
JP2004533811A (ja) 2001-01-12 2004-11-11 ジェネティクス インスティテュート，エルエルシー ２型サイトカインレセプターおよび２型サイトカインレセプターをコードする核酸
AU2002325333B2 (en) * 2001-07-19 2008-04-03 Innate Pharma NTB-A, a surface molecule involved in natural killer cells activity
AU2003276430A1 (en) 2002-06-14 2003-12-31 Stowers Institute For Medical Research Wise/sost nucleic acid sequences and amino acid sequences
US7893218B2 (en) 2003-06-16 2011-02-22 Stowers Institute For Medical Research Antibodies that specifically bind SOST peptides
US7585501B2 (en) 2002-06-14 2009-09-08 Stowers Institute For Medical Research Compositions and methods for treating kidney disease
FR2844713A1 (fr) * 2002-09-25 2004-03-26 Exonhit Therapeutics Sa Nouvelle cible de l'angiogenese et utilisations
AU2003269557A1 (en) * 2002-10-18 2004-05-04 Lg Life Sciences Ltd. Gene families associated with cancers
NZ544618A (en) 2003-06-16 2009-02-28 Celltech R & D Inc Antibodies specific for sclerostin and methods for increasing bone mineralization
US7592429B2 (en) 2005-05-03 2009-09-22 Ucb Sa Sclerostin-binding antibody
US8003108B2 (en) 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
CL2008002775A1 (es) 2007-09-17 2008-11-07 Amgen Inc Uso de un agente de unión a esclerostina para inhibir la resorción ósea.
US8921058B2 (en) 2009-10-26 2014-12-30 Externautics Spa Prostate tumor markers and methods of use thereof
US10288617B2 (en) 2009-10-26 2019-05-14 Externautics Spa Ovary tumor markers and methods of use thereof
EP2383578A1 (en) * 2010-04-30 2011-11-02 Externautics S.p.A. Tumor marker and methods of use thereof
SMT202000095T1 (it) 2010-05-14 2020-03-13 Amgen Inc Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
JP2014509588A (ja) 2011-03-01 2014-04-21 アムジエン・インコーポレーテツド 二特異性結合剤
WO2012135035A1 (en) 2011-03-25 2012-10-04 Amgen Inc. Anti - sclerostin antibody crystals and formulations thereof
SI2739311T1 (en) 2011-08-04 2018-07-31 Amgen Inc. Method for the treatment of bone defect defects
ES2813524T3 (es) 2011-12-28 2021-03-24 Amgen Inc Método para tratar la pérdida de hueso alveolar mediante el uso de anticuerpos antiesclerostina
WO2014006100A1 (en) 2012-07-05 2014-01-09 Ucb Pharma S.A. Treatment for bone diseases
UY35148A (es) 2012-11-21 2014-05-30 Amgen Inc Immunoglobulinas heterodiméricas
CN107880126B (zh) 2012-12-21 2021-03-30 西雅图基因公司 抗ntb-a抗体及相关组合物和方法
MA41142A (fr) 2014-12-12 2017-10-17 Amgen Inc Anticorps anti-sclérostine et utilisation de ceux-ci pour traiter des affections osseuses en tant qu'élements du protocole de traitement
GB201604124D0 (en) 2016-03-10 2016-04-27 Ucb Biopharma Sprl Pharmaceutical formulation
CN112166120B (zh) 2018-03-30 2024-09-10 安姆根有限公司 C末端抗体变体

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5707829A (en) * 1995-08-11 1998-01-13 Genetics Institute, Inc. DNA sequences and secreted proteins encoded thereby
US5824504A (en) * 1996-09-26 1998-10-20 Elshourbagy; Nabil A. Human 7-transmembrane receptor and DNA
CA2283299A1 (en) * 1997-03-07 1998-09-11 Human Genome Sciences, Inc. 186 human secreted proteins
EP0998490A2 (en) * 1997-03-25 2000-05-10 Genetics Institute, Inc. Secreted proteins and polynucleotides encoding them
DE19817557A1 (de) * 1998-04-09 1999-10-21 Metagen Gesellschaft Fuer Genomforschung Mbh Menschliche Nukleinsäuresequenzen aus Ovartumorgewebe
IL139686A0 (en) * 1998-06-02 2002-02-10 Genentech Inc Secreted and transmembrane polypeptides and nucleic acids encoding the same
AU3395900A (en) * 1999-03-12 2000-10-04 Human Genome Sciences, Inc. Human lung cancer associated gene sequences and polypeptides
JP2004522402A (ja) * 1999-06-02 2004-07-29 ジェネンテック・インコーポレーテッド 同一のものをコードする分泌及び膜貫通ポリペプチドと核酸

Also Published As

Publication number Publication date
CA2632702A1 (en) 2002-03-28
JP2006223304A (ja) 2006-08-31
AU1661002A (en) 2002-04-02
WO2002024888A3 (en) 2003-07-03
WO2002024888A2 (en) 2002-03-28
JP2004526412A (ja) 2004-09-02
AU2002216610A1 (en) 2002-04-02
EP1341814A2 (en) 2003-09-10
CA2421056A1 (en) 2002-03-28

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