JP4443229B2 - 動脈瘤修復のための方法 - Google Patents
動脈瘤修復のための方法 Download PDFInfo
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- JP4443229B2 JP4443229B2 JP2003574028A JP2003574028A JP4443229B2 JP 4443229 B2 JP4443229 B2 JP 4443229B2 JP 2003574028 A JP2003574028 A JP 2003574028A JP 2003574028 A JP2003574028 A JP 2003574028A JP 4443229 B2 JP4443229 B2 JP 4443229B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12099—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder
- A61B17/12109—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel
- A61B17/12113—Occluding by internal devices, e.g. balloons or releasable wires characterised by the location of the occluder in a blood vessel within an aneurysm
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B17/12131—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device
- A61B17/12181—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices
- A61B17/1219—Occluding by internal devices, e.g. balloons or releasable wires characterised by the type of occluding device formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices expandable in contact with liquids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/10—Polypeptides; Proteins
- A61L24/102—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/043—Proteins; Polypeptides; Degradation products thereof
- A61L31/044—Collagen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/146—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B2017/00831—Material properties
- A61B2017/00889—Material properties antimicrobial, disinfectant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/12—Surgical instruments, devices or methods, e.g. tourniquets for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels, umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
- A61B2017/1205—Introduction devices
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/36—Materials or treatment for tissue regeneration for embolization or occlusion, e.g. vaso-occlusive compositions or devices
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- Life Sciences & Earth Sciences (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Biomedical Technology (AREA)
- Reproductive Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Dispersion Chemistry (AREA)
- Materials Engineering (AREA)
- Neurosurgery (AREA)
- Medicinal Chemistry (AREA)
- Cardiology (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Materials For Medical Uses (AREA)
- Surgical Instruments (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Description
動脈瘤の修復のための方法が記載される。特に、送達デバイスからの押出しに際して迅速に拡張し、選択された部位を閉塞する発泡体または液体物質の使用が記載される。
動脈瘤は、破裂、凝固または解離に対する可能性から健康に危険を有する、血管の拡張(バルーンと同様)である。脳における動脈瘤の破裂は、脳卒中を引き起こし、腹部における動脈瘤の破裂は、ショックを引き起こす。大脳の動脈瘤は、通常、発作または出血の結果として患者において検出され、そして、有意な罹患率または死亡率をもたらし得る。
従って、本発明は、これまでに選択された血管を閉塞する目的のために使用されていない迅速に拡張する物質を用いて、選択された血管を閉塞する新規の方法を包含する。
本発明は、展開機構からの押出しに際して迅速に拡張し、長い時間さらに拡張しない物質(例えば、液体または発泡体)を用いて、被験体において選択された血管を閉塞する方法を包含する。この物質は、添加物質および/またはフィラー(例えば、放射線不透過性添加物質および/または生物活性物質(例えば、サイトカイン、増殖因子など))などを含み得る。本明細書中で使用される場合、用語「拡張する」とは、容積の任意の増加をいう。用語「迅速に拡張する」とは、例えば、押出しに際して、短い時間(数秒または1秒未満の単位で)内で拡張し、そしてこの最初の拡張の後、長い時間にわたってさらに拡張しない、任意の物質をいう。同様に、用語「硬化する」または「凝固する」とは、経時的にか、別の物質との接触に際してか、またはエネルギーの適用に際してかのいずれかによって、特定の拡張した容積を有する固形塊を形成する、任意の液体物質または流動性を有する物質をいう。さらに、用語「迅速に硬化する」とは、約1時間未満、好ましくは5分未満、そしてなおより好ましくは、約30秒未満で凝固するこれらの物質のいずれかをいう。従って、本明細書中に記載される迅速に拡張する物質は、数時間または数日単位をかけて拡張を停止し、そして、所望の強度の血餅を形成する物質で狭窄される。
Claims (16)
- 被験体において、選択された部位を閉塞するためのシステムであって、該システムは以下:
該選択された部位にアクセスするための手段;
該選択された部位に、液体、ペーストまたは発泡体の形態の、流動性であり、迅速に拡張し、迅速に硬化する組成物を投与し、それによって、該部位を閉塞するための手段
を備え、
該選択された部位が動脈瘤である、システム。 - 前記組成物が1つ以上の発泡体を含む、請求項1に記載のシステム。
- 前記発泡体がポリウレタンを含む、請求項2に記載のシステム。
- 前記組成物が水分との接触に際して迅速に拡張する、請求項1〜3のいずれかに記載のシステム。
- 前記組成物が、圧力の減少に際して迅速に拡張する、請求項1〜3のいずれかに記載のシステム。
- 前記組成物が互いに接触して迅速に拡張する2つの物質を含む、請求項1〜3のいずれかに記載のシステム。
- 前記投与するための手段が、前記流動性である組成物をカテーテルから押し出すための手段を備える、請求項1〜6のいずれかに記載のシステム。
- 前記組成物がさらなる物質との接触に際して迅速に拡張し、ここで該接触が、前記カテーテルの先端部においてである、請求項7に記載のシステム。
- 前記組成物が、前記カテーテルからの押出しの圧力の減少に応答して迅速に拡張する、請求項7に記載のシステム。
- 1つ以上の生物活性物質を投与するための手段をさらに備える、請求項1〜9のいずれかに記載のシステム。
- 前記生物活性物質が前記組成物の前に投与される、請求項10に記載のシステム。
- 前記生物活性物質が前記組成物と同時に投与される、請求項10に記載のシステム。
- 前記生物活性物質が前記組成物に続いて投与される、請求項10に記載のシステム。
- 前記生物活性物質が、サイトカイン;微量金属、抗生物質およびそれらの組み合せからなる群から選択される、請求項10に記載のシステム。
- 前記組成物が脱水発泡体を含む、請求項4に記載のシステム。
- 前記脱水発泡体がコラーゲンを含む、請求項15に記載のシステム。
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/093,264 US20030171773A1 (en) | 2002-03-06 | 2002-03-06 | Methods for aneurysm repair |
PCT/US2003/006985 WO2003075746A2 (en) | 2002-03-06 | 2003-03-06 | Methods for aneurysm repair |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006174428A Division JP2006247433A (ja) | 2002-03-06 | 2006-06-23 | 動脈瘤修復のための方法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2005528934A JP2005528934A (ja) | 2005-09-29 |
JP2005528934A5 JP2005528934A5 (ja) | 2006-08-10 |
JP4443229B2 true JP4443229B2 (ja) | 2010-03-31 |
Family
ID=27804201
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2003574028A Expired - Fee Related JP4443229B2 (ja) | 2002-03-06 | 2003-03-06 | 動脈瘤修復のための方法 |
JP2006174428A Withdrawn JP2006247433A (ja) | 2002-03-06 | 2006-06-23 | 動脈瘤修復のための方法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2006174428A Withdrawn JP2006247433A (ja) | 2002-03-06 | 2006-06-23 | 動脈瘤修復のための方法 |
Country Status (6)
Country | Link |
---|---|
US (1) | US20030171773A1 (ja) |
EP (1) | EP1482858A4 (ja) |
JP (2) | JP4443229B2 (ja) |
AU (1) | AU2003217985A1 (ja) |
CA (1) | CA2477256A1 (ja) |
WO (1) | WO2003075746A2 (ja) |
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-
2002
- 2002-03-06 US US10/093,264 patent/US20030171773A1/en not_active Abandoned
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2003
- 2003-03-06 AU AU2003217985A patent/AU2003217985A1/en not_active Abandoned
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- 2003-03-06 EP EP03713963A patent/EP1482858A4/en not_active Withdrawn
- 2003-03-06 JP JP2003574028A patent/JP4443229B2/ja not_active Expired - Fee Related
- 2003-03-06 CA CA002477256A patent/CA2477256A1/en not_active Abandoned
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EP1482858A2 (en) | 2004-12-08 |
AU2003217985A8 (en) | 2003-09-22 |
CA2477256A1 (en) | 2003-09-18 |
WO2003075746A3 (en) | 2004-03-25 |
JP2005528934A (ja) | 2005-09-29 |
US20030171773A1 (en) | 2003-09-11 |
JP2006247433A (ja) | 2006-09-21 |
WO2003075746A2 (en) | 2003-09-18 |
AU2003217985A1 (en) | 2003-09-22 |
EP1482858A4 (en) | 2007-05-30 |
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