JP4417361B2 - Double emulsion microcapsule generator - Google Patents

Description

  The present invention relates to a method for producing a double emulsion / microcapsule, and relates to a technique for producing fine microspheres / emulsions / microcapsules using a plurality of liquids having low affinity such as aqueous solutions and oils.

The inventors of the present application have already filed a patent application as Patent Document 1 regarding the method and apparatus for producing emulsion microcapsules.
WO02 / 068104A1 page 6-7 FIG.

  The present invention further develops the above-described prior art and, with respect to the apparatus for producing double emulsion microcapsules, by combining crossing microchannels, various forms of double emulsion microcapsules can be easily and easily produced. An object of the present invention is to provide a double emulsion / microcapsule production apparatus.

In order to achieve the above object, the present invention provides
[1] In the double emulsion / microcapsule generating apparatus, a first cross-shaped intersection where the first dispersed phase intersects the first divided continuous phase and two directions downstream of the first cross-shaped intersection and a second cross-shaped cross-section having a path for discharging the first continuous phase, from the second downstream in two directions of cross-shaped cross-section and the third cross-shaped intersection where the second continuous phase crossing It has a double emulsion / microcapsule generating chip comprising microchannels.

[2] A first cross-shaped intersection where the first dispersed phase intersects the shunted first continuous phase, and a path for discharging the second continuous phase in two directions downstream of the first cross-shaped intersection A double-emulsion microcapsule comprising a micro-channel having a second cross-shaped intersection having a second cross- section and a third cross-shaped intersection intersecting with a second continuous phase diverted downstream of the second cross-shaped intersection A generation chip is provided.

  According to the present invention, double emulsion microcapsules of various modes can be easily and easily produced by combining intersecting microchannels.

The double emulsion microcapsule producing apparatus of the present invention includes a first cross-shaped intersection where the first dispersed phase intersects the first branched continuous phase, and two directions downstream of the first cross-shaped intersection. and a second cross-shaped cross-section having a path for discharging the first continuous phase, from the second downstream in two directions of cross-shaped cross-section and the third cross-shaped intersection where the second continuous phase crossing A double emulsion / microcapsule generating chip comprising microchannels.

Hereinafter, embodiments of the present invention will be described in detail.
FIG. 1 is an overall schematic diagram of a double emulsion / microcapsule generator showing a first reference example of the present invention, FIG. 2 is an enlarged view of part A (first intersection) in FIG. 1, and FIG. 3 is part B in FIG. It is a (2nd cross | intersection part) enlarged view.
In these drawings, the double emulsion / microcapsule generating apparatus includes a double emulsion / microcapsule generating chip 100, a supply port 102 of the first continuous phase 101, and a first continuous phase 101 supplied from the supply port 102. Microchannel 103, supply port 105 of first dispersed phase 104, second microchannel 106 to which first dispersed phase 104 is supplied from supply port 105, and first and second microchannels 103 and 106 intersect. 1 intersection (T-type intersection) 107, a third microchannel 109 to which the second dispersed phase 108 is supplied, a supply port 111 for the second continuous phase 110, and a fourth to which the second continuous phase 110 is supplied. Microchannel 112, a second intersection (three-way intersection) 113 where the third and fourth microchannels 109 and 112 intersect, Microchannels 115 Bull emulsion microcapsules 114 is supplied, consisting of the outlet 116 of the double emulsion-microcapsules 114.

Thus, in this reference example, the double emulsion microcapsule 114 is generated by combining the three-way microchannels 107 and 113.
For example, when the first microchannel 103 made of acrylic is used, W (water) / O (oil) is used at the first intersection 107 by using oil for the first continuous phase 101 and water for the first dispersed phase 104. ) Type emulsion is produced without the use of a surfactant. Of course, if a lipophilic surfactant (for example, lecithin) is added to the first continuous phase 101 side, it can be generated more stably.

Further, by adding a hydrophilic surfactant (for example, sodium dodecyl sulfate; SDS) to the second continuous phase 110, W (water) / O (oil) / W (water ) Type emulsion (double emulsion) is stably produced.
Furthermore, since liquids having different wettability become droplets at the first intersection 107 and the second intersection 113, it is further facilitated by modifying the wettability of the microchannel surface including one of the intersections. Droplets can be generated. For example, in the case of using the above-mentioned acrylic microchannel, if the vicinity of the second intersection 113 is hydrophilized, W / O / W type double emulsion can be easily generated, and conversely the vicinity of the first intersection 107. If a hydrophilization treatment is carried out, O / W / O type double emulsion formation becomes easy.

Alternatively, a plurality of microchannels (106) or the like arranged in the horizontal direction may be arranged, and a plurality of intersections may be arranged.
4 is an overall schematic view of a double emulsion / microcapsule producing apparatus showing a modification of the first reference example of the present invention, FIG. 5 is an enlarged view of a portion C (first intersecting portion) in FIG. 4, and FIG. It is a D section (2nd crossing part) enlarged view of.

  In these drawings, 150 is a first double emulsion microcapsule generating chip, 151 is a first dispersed phase, 152 is a supply port of the first dispersed phase, 153 is a first microphase that supplies the first dispersed phase 151. 154 is a first continuous phase, 155 is a supply port of the first continuous phase 154, 156 is a second microchannel to which the first continuous phase 154 is supplied, and 157 is a first and second microchannel 153. 156 is a second disperse phase, 159 is a third microchannel to which the second disperse phase 158 is supplied, and 160 is a second disperse phase. , 161 is a connection flow path, 170 is a second double emulsion microcapsule generating chip, and 171 is connected to the discharge port 160 of the second dispersed phase via the connection flow path 161. 2 disperse phase supply port, 172 is a fourth microchannel to which the second disperse phase 158 is supplied, 173 is the second continuous phase, 174 is the second continuous phase supply port, and 175 is supplied by the second continuous phase 173 The fifth microchannel 176 is the second intersection (T-shaped intersection) where the fourth and fifth microchannels 172 and 175 intersect, 177 is the double emulsion microcapsule, 178 is the double emulsion The transport microchannel 179 of the microcapsule 177 is an outlet for the double emulsion microcapsule 177.

  In this reference example, a first double emulsion / microcapsule generating chip 150 having a first intersection (T-type intersection) 157 and a second double emulsion having a second intersection (T-type intersection) 176. By connecting the microcapsule generation chip 170 with the connection flow path 161 and combining the two T-type microchannels 157 and 176, a microchannel having two T-type microchannels can be easily constructed. .

7 is an overall schematic diagram of a double emulsion / microcapsule producing apparatus showing a second reference example of the present invention, FIG. 8 is an enlarged view of a portion E (first intersection) in FIG. 7, and FIG. 9 is a portion F in FIG. It is a (2nd cross | intersection part) enlarged view.
In these drawings, the double emulsion / microcapsule generating apparatus is supplied with a double emulsion / microcapsule generating chip 200, a supply port 202 of the first continuous phase 201, and a first continuous phase 201 diverted from the supply port 202. The first microchannel 203 and the second microchannel 204, the supply port 206 of the first dispersed phase 205, the third microchannel 207 to which the first dispersed phase 205 is supplied from the supply port 206, the first and second First micro-channels 203 and 204 and the third micro-channel 207 intersect with each other, a first intersection (cross-shaped intersection) 208, a fourth micro-channel 210 supplied with a second dispersed phase 209, and a second continuous phase 211, the fifth microchannel 213 to which the second continuous phase 211 is supplied, the fourth and fifth Microchannels 216 the second cross-section (T-type intersection) 214 microchannel 210 and 213 intersect, double emulsion-microcapsules 215 is transported, made from the discharge port 217 of the double emulsion-microcapsules 215.

Thus, in this reference example, a double emulsion microcapsule can be generated by combining the cross-shaped microchannel 208 and the T-shaped microchannel 214.
In this reference example, the first intersecting portion (cross-shaped intersecting portion) 208 and the second intersecting portion (T-shaped intersecting portion) 214 are interchanged, and the first intersecting portion is replaced with the T-type microchannel and the second intersecting portion. It is also possible to use cross-shaped microchannels at the intersections.

FIG. 10 is an overall schematic diagram of a double emulsion / microcapsule producing apparatus showing a modification of the second reference example of the present invention, FIG. 11 is an enlarged view of a G part (first intersecting part) in FIG. 10, and FIG. It is a H section (2nd crossing part) enlarged view.
In these drawings, 250 is a first double emulsion microcapsule generating chip, 251 is a first continuous phase, 252 is a supply port of the first continuous phase 251, and 253 is a first continuous phase 251 that is branched from the supply port 252. The first microchannel 254 is supplied, 254 is the second microchannel supplied with the first continuous phase 251 diverted from the supply port 252, 255 is the first dispersed phase, 256 is the first dispersed phase supply port, 257 is a third microchannel to which the first dispersed phase is supplied, 258 is a first intersection (cross-shaped) where the first and second microchannels 253 and 254 intersect with the third microchannel 257 259 is the second dispersed phase, 260 is the fourth microchannel to which the second dispersed phase 259 is supplied, 261 is the outlet of the second dispersed phase 259, and 262 is the contact The flow path, 270 is the second double emulsion microcapsule generating chip, 271 is the second dispersed phase supply port connected to the discharge port 261 of the second dispersed phase 259 via the connection flow path 262, and 272 is the first A fifth microchannel connected to the supply port 271 of the second disperse phase 259 and supplied with the second disperse phase 259, 274 is a supply port of the second continuous phase 273, and 275 is supplied with the second continuous phase 273. 6 microchannels, 276 is a second intersection (T-shaped intersection) where the fifth and sixth microchannels 272 and 275 intersect, 277 is a double emulsion microcapsule, and 278 is its double emulsion microcapsule 277 The conveying microchannel 279 is an outlet of the double emulsion microcapsule 277.

  In this reference example, a first double emulsion microcapsule generating chip 250 having a first intersection (cross-shaped intersection) 258 and a second double emulsion having a second intersection (T-shaped intersection) 276. By connecting the microcapsule generation chip 270 with the connection flow path 262, a microchannel combining a cross-shaped microchannel and a T-type microchannel of different modes can be easily constructed.

According to FIG. 4 and FIG. 10 described above, even when microchannels of different materials are used, double emulsion microcapsules can be generated by connecting with the connection flow paths 161 and 262.
For example, the first double emulsion / microcapsule generation chip 150, 250 is made of acrylic, and the second double emulsion / microcapsule generation chip 170, 270 is made of glass, so that a W / O / W type emulsion / microcapsule is formed. Can be generated.

FIG. 13 is an overall configuration diagram of a double emulsion / microcapsule generator showing a further modification of the second reference example of the present invention, FIG. 13 (a) is a top view thereof, and FIG. It is AA sectional view taken on the line of a).
In these drawings, 280 is a first double emulsion microcapsule generating chip, 281 is a first continuous phase, 282 is a supply port of the first continuous phase 281, and 283 is a first continuous phase 281 that is branched from the supply port 282. Is supplied to the first microphase, 284 is the second microchannel supplied with the first continuous phase 281 diverted from the supply port 282, 285 is the first dispersed phase, and 286 is the supply port of the first dispersed phase 285. Reference numeral 287 denotes a third microchannel to which the first dispersed phase 285 is supplied, and reference numeral 288 denotes a first intersection (cross-shaped intersection) where the first, second and third microchannels 283, 284 and 287 intersect. ) 289 is the second dispersed phase, 290 is the fourth microchannel to which the second dispersed phase 289 is supplied, 291 is the outlet of the second dispersed phase, 292 is the connection flow path, 29 Is a second double emulsion / microcapsule generating chip disposed at the lower part of the first double emulsion / microcapsule generating chip 280, and a second disperse phase 289 is supplied to the fifth double emulsion / microcapsule generating chip 294, which is supplied to the fifth disperse phase 289. , 295 is the second continuous phase, 296 is the supply port of the second continuous phase 295, 297 is the sixth microchannel to which the second continuous phase 295 is supplied, 298 is the fifth and sixth microchannels 294 , 297 intersects the second intersection (T-shaped intersection), 299A is a double emulsion microcapsule transport microchannel, and 299B is a double emulsion microcapsule outlet.

In the case of this reference example, as described above, the first double emulsion / microcapsule generation chip 280 and the second double emulsion / microcapsule generation chip 293 are stacked one above the other.
4 and FIG. 10 show the case where the channels are connected in the horizontal direction, but this FIG. 13 shows the case where they are stacked one above the other, and the microchannels of different materials are the same as in FIG. 4 and FIG. May be used.

FIG. 14 is an overall schematic diagram of a double emulsion / microcapsule producing apparatus showing a third reference example of the present invention.
In this figure, 300 is a double emulsion microcapsule generating chip, 301 is a first continuous phase, 302 is a supply port for the first continuous phase 301, and 303 is a first microchannel to which the first continuous phase 301 is supplied. , 304 is the first dispersed phase (1), 305 is the supply port of the first dispersed phase (1) 304, 306 is the second microchannel to which the first dispersed phase (1) 304 is supplied, and 307 is the first 1, an intersection where the second microchannels 303 and 306 intersect (T-shaped intersection), 308 is a second dispersed phase (1) downstream from the intersection (T-shaped intersection) 307, 309 is the second The third microchannel to which the dispersed phase (1) 308 is supplied, 310 is the first dispersed phase (2), 311 is the supply port of the first dispersed phase (2) 310, and 312 is the first dispersed phase (2). The fourth supplied 310 Microchannel 313 is an intersection where the third and fourth microchannels 309 and 312 intersect (T-shaped intersection), 314 is a second dispersed phase (2) downstream from the intersection (T-shaped intersection) 313 315 is the fifth microchannel to which the second dispersed phase (2) 314 is supplied, 316 is the second continuous phase, 317 is the supply port of the second continuous phase 316, and 318 is supplied by the second continuous phase 316 The sixth microchannel 319 is the intersection where the fifth and sixth microchannels 315 and 318 intersect (T-shaped intersection), 320 is the double emulsion microcapsule produced, 321 is the double emulsion Conveyance microchannels 322 of the microcapsules 320 are discharge ports of the double emulsion microcapsules 320.

In this reference example, the number of dispersed phase supply ports is increased. That is, by increasing the flow rate of the first dispersed phase, the amount of liquid droplets contained in the double emulsion / microcapsule is increased.
FIG. 15 is an overall schematic diagram of a double emulsion / microcapsule producing apparatus showing a fourth reference example of the present invention.

  In this figure, 400 is a double emulsion microcapsule generating chip, 401 is a first continuous phase, 402 is a supply port of the first continuous phase 401, and 403 is a first microchannel to which the first continuous phase 401 is supplied. , 404 is a first dispersed phase, 405 is a supply port for the first dispersed phase 404, 406 is a second microchannel to which the first dispersed phase 404 is supplied, and 407 is a first and second microchannel 403. 408 is supplied with the second dispersed phase (1) 408 downstream of the intersection (T-type intersection) 407, and 409 is supplied with the second dispersed phase (1) 408. The third microchannel 410 is an intersection (second T-shaped intersection) of the third microchannel 409 and the third microchannel 409 to which the second dispersed phase (1) 408 is supplied. A is the remaining second disperse phase (2) which is not discharged, 411 is a part of the first continuous phase discharged from the intersection 410, 412 is a discharge microchannel of the first continuous phase 411, 413 is the first continuous phase The outlet of the phase 411, 414 is the fourth microchannel supplied with the remaining second dispersed phase (1) 408 that is not discharged, 415 is the second continuous phase, 416 is the supply port of the second continuous phase 415, 417 Is the fifth microchannel to which the second continuous phase 415 is supplied, 418 is the intersection where the fourth and fifth microchannels 414 and 417 intersect (T-shaped intersection), 419 is the double emulsion micro produced Capsule, 420 is a transport microchannel of the generated double emulsion microcapsule 419, and 421 is a discharge of the generated double emulsion microcapsule 419. It is a mouth.

Also in this reference example, as in the third reference example, the amount of liquid droplets contained in the double emulsion microcapsules is increased by decreasing the flow rate ratio of the first continuous phase with respect to the dispersed phase. .
FIG. 16 is an overall schematic view of a double emulsion / microcapsule generator showing a first embodiment of the present invention.

  In this figure, 500 is a double emulsion microcapsule generating chip, 501 is a first continuous phase, 502 is a supply port of the first continuous phase 501, and 503 is supplied by a first continuous phase 501 divided from the supply port 502. The first microchannel 504, the second microchannel 504 supplied with the first continuous phase 501 diverted from the supply port 502, 505 the first dispersed phase, 506 the supply port of the first dispersed phase 505, Reference numeral 507 denotes a third microchannel to which the first dispersed phase 505 is supplied, and reference numeral 508 denotes a first intersection (cross-shaped intersection) where the first, second, and third microchannels 503, 504, and 507 intersect. ), 509 is the second dispersed phase (1), 510 is the fourth microchannel supplied with the second dispersed phase (1) 509, 511 is the second intersection (cross-shaped intersection), 5 2 is a first discharge microchannel from which a part of the first continuous phase 501 in the second dispersed phase (1) 509 is discharged, 513 is a first discharge port of the first continuous phase 501 514 is the first A second discharge microchannel from which a part of the continuous phase 501 is discharged, 515 is a discharge port of the first continuous phase 501, 516 is a remaining second dispersed phase (not discharged) connected to the second intersection 511 ( 1) The fifth microchannel to which 509 is supplied, 517 is the first second continuous phase, 518 is the supply port of the first second continuous phase 517, and 519 is the first second continuous phase 517. The sixth microchannel, 520 is the second second continuous phase, 521 is the supply port of the second second continuous phase 520, and 522 is the seventh microchannel to which the second second continuous phase 520 is supplied. 523 is the third intersection (cross-shaped intersection), 524 is Double Emulsion microcapsules form, 525 transport microchannels double emulsion-microcapsules 524 produced, 526 are outlet double emulsion-microcapsules 524 generated.

FIG. 17 is an overall schematic view of a double emulsion / microcapsule producing apparatus showing a second embodiment of the present invention.
In this figure, 600 is a double emulsion microcapsule generating chip, 601 is a first continuous phase, 602 is a supply port of the first continuous phase 601, and 603 is supplied with a first continuous phase 601 that is branched from the supply port 602. 604 is a second microchannel supplied with a first continuous phase 601 diverted from a supply port 602, 605 is a first dispersed phase, 606 is a supply port for the first dispersed phase 605, 607 Is a third microchannel to which the first dispersed phase 605 is supplied, and 608 is a first intersection (cross-shaped intersection) where the first, second and third microchannels 603, 604 and 607 intersect. , 609 is the second dispersed phase, 610 is the fourth microchannel to which the second dispersed phase 609 is supplied, 611 is the second intersection (cross-shaped intersection), and 612 is the second dispersed phase. A first discharge microchannel from which a portion of 09 is discharged, 613 is a first discharge port of the second dispersed phase 609, and 614 is a second discharge microchannel from which a portion of the second dispersed phase 609 is discharged. 615 is a second outlet of the second disperse phase 609, 616 is a fifth microchannel to which the remaining second disperse phase 609 that is not discharged is connected to the second intersection 611, 617 is the first Two continuous phases, 618 is a supply port of the second continuous phase 617, 619 is a sixth microchannel to which the second continuous phase 617 is divided and supplied, and 620 is a seventh microchannel to which the second continuous phase 617 is divided and supplied. 621 is a third intersection (cross-shaped intersection), 622 is a generated double emulsion microcapsule, and 623 is a transfer emulsion of the generated double emulsion microcapsule 622. Rochaneru, 624 is a discharge port of the double emulsion-microcapsules 622 generated.

  FIG. 18 is a view showing the produced W / O / W type double emulsion showing an example of the present invention, and is an acrylic cross-shaped microchannel (dispersed phase side 40 μm × 40 μm, continuous phase side 100 μm × 100 μm) and glass. It is an example of a double emulsion microcapsule produced by a T-type microchannel (dispersed phase side 40 μm × 40 μm, continuous phase side 100 μm × 100 μm). The flow rate is 0.01 ml / h for the first dispersed phase, 0.5 ml / h for the first continuous phase, and 25 ml / h for the second continuous phase.

FIG. 19 is a schematic view of an apparatus for controlling the droplet diameter and the number of droplets contained in the first double emulsion microcapsule of the reference example of the present invention.
In this figure, a double emulsion / microcapsule generating device includes a double emulsion / microcapsule generating chip 700, a supply port 702 of a first continuous phase 701, and a first micro to which a first continuous phase 701 is supplied from the supply port 702. The channel 703, the supply port 705 of the first dispersed phase 704, the second microchannel 706 to which the first dispersed phase 704 is supplied from the supply port 705, and the first and second microchannels 703 and 706 intersect with each other. 1 intersection (the first T-type microchannel 707, the third microchannel 709 supplied with the second dispersed phase 708, the supply port 711 of the second continuous phase 710, the first continuous phase 710 supplied 4 microchannels 712, and a second intersection (second T) where the third and fourth microchannels 712 and 709 intersect. Micro Channel) 713, the transport microchannel 715 double emulsion-microcapsules 714 is supplied, consisting of the outlet 716 of the double emulsion-microcapsules 714.

The first variable flow rate pump 723 is provided in the path of the supply port 702 of the first continuous phase 701, and the second variable flow rate pump 724 is provided in the path of the supply port 705 of the first dispersed phase 704, and the second continuous phase. A third flow rate variable pump 725 is connected to the path of the supply port 711 of 710.
Further, in the particle diameter / production number measuring device 726, the particle diameter / production number measurement at the first intersection (first T-type microchannel) 707 is performed. The particle diameter and the number of generations are measured at the second intersection (first T-type microchannel) 713, respectively. The information from the particle size / production number measuring devices 726, 727 is taken into the controller 722, and the first flow rate variable so that the predetermined particle size / production number preset by the computer (PC) 721 is obtained. The pump 723, the second variable flow rate pump 724, and the third variable flow rate pump 725 are controlled.

Thus, FIG. 19 shows the measurement of the droplet diameter and the number of droplets contained in the double emulsion microcapsule with a camera, capacitance, etc., and the first flow variable pump 723 and the second flow variable pump 724. To control. Further, the droplet diameter and the number of droplets are also counted at the second intersection 713 to control the third flow rate variable pump 725.
FIG. 20 is a schematic view of an apparatus for controlling the droplet diameter and the number of droplets contained in the second double emulsion microcapsule of the reference example of the present invention.

  In this figure, 800 is a double emulsion microcapsule generating chip, 801 is a first continuous phase, 802 is a supply port of the first continuous phase 801, and 803 is a first microchannel to which the first continuous phase 801 is supplied. , 804 is the first dispersed phase, 805 is the supply port of the first dispersed phase 804, 806 is the third microchannel to which the first dispersed phase 801 is supplied, 807 is the first and second microchannels 803 and 806 is a first intersection (T-shaped intersection), 808 is a third microchannel supplied with a first continuous phase 801 connected to the first intersection 807, and 809 is a second intersection ( 810 is a microchannel branched from the third microchannel 808 and a part of the first continuous phase 801 is discharged; 811 is an outlet of the first continuous phase 801; 81 Is the second continuous phase, 813 is the supply port of the second continuous phase 812, 814 is the fifth microchannel to which the second dispersed phase 812 is supplied, 815 is the third and fifth microchannels 808 and 814 The third intersection (T-shaped intersection), 816 is a double emulsion microcapsule generated from the third intersection 815, 817 is a generation microchannel of the double emulsion 816, and 818 is the double emulsion microcapsule 816. It is a discharge port.

Further, the first variable flow rate pump 823 is provided in the path of the supply port 802 of the first continuous phase 801, and the second variable flow rate pump 824 is provided in the path of the supply port 805 of the first dispersed phase 804, and the second continuous phase. A third variable flow rate pump 825 is connected to the path of the supply port 813 812, and a variable flow rate valve 828 is connected to the path of the discharge port 811 of the first continuous phase.
Further, in the particle diameter / production number measuring device 826, the particle diameter / production number measurement at the first intersection (T-type intersection) 807 is performed. The particle diameter and the number of generations are measured at the intersection (T-type intersection) 815, respectively. The information from the particle size / production number measuring devices 826, 827 is taken into the controller 822, and the first flow rate variable so that the predetermined particle size / production number preset by the computer (PC) 821 is obtained. The pump 823, the second variable flow rate pump 824, the third variable flow rate pump 825, and the variable flow rate valve 828 are controlled.

  FIG. 20 described above is a case where the number of droplets contained in the double emulsion microcapsule is controlled more precisely. The control of the number of droplets is performed more precisely by discharging the first continuous phase through the variable flow rate valve 828. The third intersecting portion 815 counts the droplet diameter and the number of droplets to control the third variable flow rate pump 825. In some cases, the first and second variable flow rate pumps 823 and 824 are also controlled.

In each of the above examples, there was one microchannel through which the double emulsion microcapsules were discharged. Therefore, it is necessary to provide a plurality of individual microchannel devices for mass production.
In order to avoid this and achieve mass production, it is configured as follows.
FIG. 21 is a schematic diagram of a first mass production type double emulsion microcapsule producing apparatus (device) of a reference example of the present invention.

In this figure, 900 is a device for producing double emulsion microcapsules, 901 and 902 are supply ports for the first continuous phase, 903 is a supply port for the dispersed phase, 904 and 905 are the first intersections, and 906 and 907 are the first intersections. Two continuous-phase supply ports, 908 and 909 are second intersections, and 910 is a double emulsion / microcapsule recovery port.
FIG. 22 is a schematic view of a second mass production type double emulsion microcapsule producing apparatus (device) of a reference example of the present invention.

In this figure, 950 is a device for generating double emulsion microcapsules, 951 is a supply port for the first continuous phase, 952 is a supply port for the dispersed phase, 953 and 954 are the first intersection, and 955 and 956 are the second continuous port. Phase supply ports, 957 and 958 are second intersections, and 959 is a double emulsion emulsion / microcapsule recovery port.
In the above embodiment, T-type intersection is merely a described as an example of a three-way intersection.

In the present invention, double emulsion microcapsules of various embodiments can be easily and easily produced by combining intersecting microchannels. For example, microspheres and emulsion microcapsules can be prepared using a plurality of liquids having low affinity such as aqueous solutions and oils.
In addition, this invention is not limited to the said Example, A various deformation | transformation is possible based on the meaning of this invention, and these are not excluded from the scope of the present invention.

  The double emulsion / microcapsule producing apparatus of the present invention can be used to easily and easily produce various forms of double emulsion / microcapsules.

BRIEF DESCRIPTION OF THE DRAWINGS It is a whole schematic diagram of the double emulsion microcapsule production | generation apparatus which shows the 1st reference example of this invention. It is the A section (1st crossing part) enlarged view of FIG. It is the B section (2nd crossing part) enlarged view of FIG. It is a whole schematic diagram of the double emulsion microcapsule production | generation apparatus which shows the modification of the 1st reference example of this invention. It is the C section (1st crossing part) enlarged view of FIG. It is the D section (2nd crossing part) enlarged view of FIG. It is a whole schematic diagram of the double emulsion microcapsule production | generation apparatus which shows the 2nd reference example of this invention. It is the E section (1st crossing part) enlarged view of FIG. It is the F section (2nd crossing part) enlarged view of FIG. It is a whole schematic diagram of the double emulsion microcapsule production | generation apparatus which shows the modification of the 2nd reference example of this invention. It is the G section (1st cross | intersection part) enlarged view of FIG. It is the H section (2nd crossing part) enlarged view of FIG. It is a whole block diagram of the double emulsion microcapsule production | generation apparatus which shows the further modification of the 2nd reference example of this invention. It is a whole schematic diagram of the double emulsion microcapsule production | generation apparatus which shows the 3rd reference example of this invention. It is a whole schematic diagram of the double emulsion microcapsule production | generation apparatus which shows the 4th reference example of this invention. BRIEF DESCRIPTION OF THE DRAWINGS It is the whole schematic diagram of the double emulsion microcapsule production | generation apparatus which shows 1st Example of this invention. It is a whole schematic diagram of the double emulsion microcapsule production | generation apparatus which shows 2nd Example of this invention. It is a figure which shows the produced | generated W / O / W type double emulsion microcapsule which shows the Example of this invention. It is a schematic diagram of the apparatus for controlling the droplet diameter of the 1st double emulsion microcapsule of the reference example of this invention, and the droplet number contained inside. It is a schematic diagram of the apparatus for controlling more precisely the droplet diameter and the number of droplets contained in the second double emulsion microcapsule of the reference example of the present invention. It is a schematic diagram of the production | generation apparatus (device) of the 1st mass production type double emulsion microcapsule of the reference example of this invention. It is a schematic diagram of the production | generation apparatus (device) of the 2nd mass-production type double emulsion microcapsule of the reference example of this invention.

100, 200, 300, 400, 500, 600, 700, 800 Double emulsion microcapsule generation chip 101,154,201,251,281,301,308,401,408,411,501,601,701,801 1 continuous phase 102, 155, 202, 252, 282, 302, 402, 502, 602, 702, 802, 901, 902, 951 First continuous phase supply port 103, 106, 109, 112, 115, 153, 156 , 158, 172, 175, 178, 203, 204, 207, 210, 213, 216, 253, 254, 257, 260, 272, 275, 278, 283, 284, 287, 290, 294, 297, 299A, 303 , 306, 309, 312, 315, 318, 321 03,406,409,412,414,417,420,503,504,507,510,512,514,516,519,522,525,603,604,607,610,612,614,616,619, 620, 623, 703, 706, 709, 712, 715, 803, 806, 808, 810, 814, 817 Microchannel 104, 151, 205, 255, 285, 304, 404, 505, 605, 704, 804 1st Dispersed phase 105, 152, 206, 256, 286, 305, 405, 506, 606, 705, 805 First dispersed phase supply port 107, 157, 208, 258, 288, 508, 608, 707, 807, 904 905, 953, 954 First intersection 108, 159, 209, 259 , 289, 310, 408A, 509, 609, 708 Second dispersed phase 110, 173, 211, 273, 295, 316, 415, 517, 520, 617, 710, 812 Second continuous phase 111, 174, 212, 274 , 296, 317, 416, 518, 521, 618, 711, 813, 906, 907, 955, 956 Second continuous phase supply port 113, 176, 214, 276, 298, 511, 611, 713, 809, 908 , 909, 957, 958 Second intersection 114, 177, 215, 277, 320, 419, 524, 622, 714 Double emulsion microcapsule 116, 179, 217, 279, 299B, 322, 421, 526, 624 , 716 Double emulsion microcapsule outlet 150 250, 280 First double emulsion / microcapsule generation chip 160, 261, 291 Second dispersed phase outlet 161, 262, 292 Connection flow path 170, 270, 293 Second double emulsion / microcapsule generation chip 171 271, 311 Second disperse phase supply port 307, 313, 319, 407, 408, 410, 418 Intersection 413, 811 First continuous phase discharge port 513 First continuous phase first discharge port 515 First continuous Phase second outlet 523,621,815 Third intersection 613 First continuous phase first outlet 615 First continuous phase second outlet 721,821 Computer 722,822 Controller 723,823 First variable flow pump 724, 824 Second variable flow pump 725, 825 Third flow possible Pump 726, 727, 826, 827 Measuring device for particle size and number of generation 816 Double emulsion microcapsule 818 Double emulsion microcapsule outlet 828 Variable flow valve 900,950 Double emulsion microcapsule generator 903,952 1 Disperse phase supply port 910,959 Double emulsion / microcapsule recovery port

Claims (2)

A first cruciform intersection where the first dispersed phase intersects the diverted first continuous phase, and a path that discharges the first continuous phase in two directions downstream of the first cruciform intersection. Double emulsion microcapsule generation chip comprising a microchannel having two cross-shaped intersections and a third cross-shaped intersection where the second continuous phase intersects from two directions downstream of the second cross-shaped intersection A double emulsion / microcapsule producing apparatus comprising: A first cruciform intersection where the first dispersed phase intersects the diverted first continuous phase, and a path for discharging the second continuous phase in two directions downstream of the first cruciform intersection. A double-emulsion microcapsule generating chip comprising a microchannel having two cross-shaped intersections and a third cross-shaped intersection where the second continuous phase that is divided downstream of the second cross-shaped intersection intersects A double emulsion / microcapsule producing apparatus comprising:

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