JP4367791B1 - Method for producing a drug in which the time until the start of the action in the administration of an antihypertensive agent into the abdominal cavity is delayed - Google Patents

Abstract

The present invention provides a method for delaying the action by intraperitoneal administration of a pharmaceutical agent.
A rice flour is kneaded with distilled water and a ball is 10 mm. After creating a hole toward the center and sealing the blood pressure medicine etc. in this hole, the hole is closed with the same material and rounded, and the action of the blood pressure agent in intraperitoneal administration is delayed Method. Spheres administered into the abdominal cavity take 3 to 4 hours, and the exposed drug starts to dissolve and acts.
[Selection] Figure 4

Description

This application lowers blood pressure in hypertensive patients, made for the purpose of stabilizing the everyday life, and, except that forms in a state of wrapping produced medicine rice flour, and H ₂ blocker proton pump agent of gastric acid secretion inhibitor such as Encapsulating drugs for the purpose of inhibiting gastric acid secretion, such as “drugs for lowering blood pressure” and “antihypertensive agents” and H ₂ blockers and proton pumps. Regarding the method.

  This is a method of delaying the action by intraperitoneal administration of pharmaceuticals.

(1) [Patent 40658810] A method for producing an attached raw capsule.
(2) [Special Table 2005-515320]
A method for producing a pharmaceutical agent comprising an active cushioning component.
(3) [Japanese Patent Publication No. 5194294] Die press-molded capsule and method for producing the same.

JP2007-143451A Conventionally, in the intraperitoneal administration of medicines, there have been methods of taking hard-to-drink medicines with a bitter taste in capsules or in capsule form.

  In addition, there are drugs that have been devised so that they do not dissolve until they reach the stomach by mixing bandits and the like at the pharmaceutical stage.

  Unlike the conventional methods, the present application has developed a method for delaying the action of a drug that is devised so that the drug administered into the abdominal cavity does not immediately dissolve but starts to dissolve after 3 to 4 hours.

Describe the method in a bulleted list.
1. Batter of rice flour with distilled water or the like, consolidate Ku round to spherical (through ≒ 10mm).
2. While soft, make a hole (hole) toward the center with a stick or the like.
3. Put this ball in boiling water and boil for 1-2 hours.
Dry for 4.5 minutes to 1 hour.
5. The desired medicine is contained in the hole, and the hole is covered.
6). It is formed by rounding and further drying.

  Although Patent Document 1 was referred to, as an invention close to the present application, there were few examples and it was a very strict choice. As long as this invention deals with epilepsy and hypertension in claim 18, this invention is inevitable. In the invention, glucomannan and koji, which are the main components of konjac, are completely different from the present invention, and are food improvers. It is characterized by containing the desired medicine in rice flour.

  There is no prior application that seems to be close to the present invention, and there is a method of wrapping in the above-mentioned oblate, or processing into a capsule, or using a bandit or a curing agent. However, these are treatments for different purposes and reaching the stomach.

Specifically, the manufacturing process is described in a cylindrical book.
1. Neri easily formed rice flour with distilled water or the like, solidifying Ku round spherical diameter 10 mm.
The process of forming round by hand.
2. A process of making a hole with a diameter of 7 mm toward the center with a punch or the like between soft holes.
3. The process of hardening this ball in boiling water for 1-2 minutes.
Dry for 4.5 minutes to 1 hour by natural drying or drying.
5. A step of putting a tablet such as a target drug (antihypertensive agent) into the hole (1).
6). After this, the stopper is packed, and the stopper is made of a material that has been cut out in advance.

  The rice powder was formed in a round shape and a hole (1) was made in the center to solve various problems. For example, when the drug is boiled in a contained state, it heats up, so the drug dissolves or is less effective I avoided the problem of becoming.

  Chemicals that are chemically produced in 1-2 minutes begin to dissolve and even their components change, so we want to avoid this.

Means for solving the problem

I encountered the above difficulties at the time of molding, but found a solution, threshed rice flour particles with water, kneaded with water, solidified into a clay shape and then shaped into a sphere, but with a diameter of 10 mm toward the center The hole (1) is provided, and this state is made by filling the hole with medicine after 5 minutes to 1 hour of drying, and forming a round shape with a lid .

  After forming the rice flour round, open the hole (1) and boil in that state, currently there is no number in the rice flour, and the number indicating the state of the particles is not consistent and unified by the manufacturing plant That is the situation.

  It is important to dry for 5 minutes to 1 hour, and then enclose the medicine (3) in the hole (1), close the hole with the same rice flour, and close with the same component rice flour.

By doing so, spheres are uniformly formed and the dissolution starts smoothly even after intraperitoneal administration.

The invention's effect

The effect is now complete. The effect is that the drug (3) is mainly administered intraperitoneally. The most required thing is that when it is administered intraperitoneally, the round spherical balls of rice flour are gradually digested. confirmed. The blood pressure drops and keeps stable as intended.

From the above-mentioned kneading, the intraperitoneal administration is performed through the final process, and the drug starts to dissolve after 3 to 4 hours. (The rice flour does not dissolve for a long time when it hardens).

So to clarify why I thought, the inventor is suffering from high blood pressure, and the medicine prescribed by the clinician only increases or decreases that amount.

Under these conditions, it is very difficult to control blood pressure. For a long time, it seemed that the attending physician also threw a spoon.

However, the attending physician is trying to do something without giving up at a considerable effort. However, this also does not lead to stable blood pressure.

Therefore, the applicant felt that they had to think a little, and decided on a method of medication.

The first thing I came up with was delaying the action.

And this came to the application, that is, rice flour (harmless to the human body) was formed in a round shape, opened a hole (1) toward the center, and then sealed the blood pressure medicine (3) and closed the hole (1) again. .

Applicants are sick and often go to bed at about 9pm, but if they say they should drink before going to bed, they are required to drink at that time.

This is not good. If you go to bed at 9pm, you won't last long if you take the medicine until 6:00 am. However, a drop in blood pressure cannot be expected with this application alone, and it must be a medication that includes this application.

As a result of various considerations, the present invention was reached, and it was administered intraperitoneally, or when the applicant himself tried drinking it, the blood pressure was considerably high for 5 or 10 years.

When you start drinking, it drops to about 140-160 and keeps that value.

The present application defined as rice flour is not in time for other flours. I realized a subtle difference in manufacturing and was drowned in the excellence of this material. But if you can't force it, you can use flour.

When it is made of flour, it is sticky and difficult to mold. In addition, problems such as short digestion time in the abdominal cavity arise. That's why I avoided flour.

Rice flour is kneaded into a spherical shape and processed perspective view (diameter about 10mm or less) Illustration before encapsulating medicine A state in which a hole is made in a hardened spherical sphere (block diagram) The state of closing the hole.

1. Ball hole Block (use the punched out place)
3. Medicine (not limited to shape)
4). Balloon (just after boiling)

Claims (1)

Process comprising the steps of making a sphere (5) having a diameter of 1 0 m m in rice flour, a hole (1) for encapsulating drugs (3) on the sphere (5), open towards the center of the sphere (5) A step of boiling the bulb (5) for 1-2 minutes, a step of drying the bulb (5) for about 1 hour, a drug for lowering blood pressure in the hole (1), and H ₂ blocker proton pump agent, a step of encapsulating the gastric acid secretion inhibitor, etc. (3) closing the hole (1) is the sphere (5) the same material as (2), round the sphere (5) and forming method of a medicament which is adapted to delay the time until the start of in acting on the given antihypertensive agent projecting into the peritoneal cavity, characterized in that performing in this order.

Images