JP4361859B2 - Full thickness ablation device - Google Patents

Full thickness ablation device Download PDF

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JP4361859B2
JP4361859B2 JP2004506666A JP2004506666A JP4361859B2 JP 4361859 B2 JP4361859 B2 JP 4361859B2 JP 2004506666 A JP2004506666 A JP 2004506666A JP 2004506666 A JP2004506666 A JP 2004506666A JP 4361859 B2 JP4361859 B2 JP 4361859B2
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tissue
tissue stapling
cable
shaft
head assembly
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JP2005526568A (en
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ケー シャルマ サティシュ
アイ フリード デビッド
パトロニク ニコラス
エム ウェンドランド ジェフリー
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Boston Scientific Ltd Barbados
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/068Surgical staplers, e.g. containing multiple staples or clamps
    • A61B17/072Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
    • A61B17/07207Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously the staples being applied sequentially
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/28Surgical forceps
    • A61B17/29Forceps for use in minimally invasive surgery
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32Surgical cutting instruments
    • A61B17/320016Endoscopic cutting instruments, e.g. arthroscopes, resectoscopes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00353Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery one mechanical instrument performing multiple functions, e.g. cutting and grasping
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/068Surgical staplers, e.g. containing multiple staples or clamps
    • A61B17/072Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
    • A61B2017/07214Stapler heads
    • A61B2017/07221Stapler heads curved
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/068Surgical staplers, e.g. containing multiple staples or clamps
    • A61B17/072Surgical staplers, e.g. containing multiple staples or clamps for applying a row of staples in a single action, e.g. the staples being applied simultaneously
    • A61B2017/07214Stapler heads
    • A61B2017/0725Stapler heads with settable gap between anvil and cartridge, e.g. for different staple heights at different shots
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/28Surgical forceps
    • A61B17/29Forceps for use in minimally invasive surgery
    • A61B2017/2901Details of shaft
    • A61B2017/2905Details of shaft flexible

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Surgery (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Surgical Instruments (AREA)
  • Dental Preparations (AREA)

Abstract

A full thickness resection device comprises a control handle including an actuator wherein, when the device is in an operative position within a body lumen of a patient, the control handle remains outside the patient's body and a working head assembly coupled to a control handle by a flexible sheath, wherein, when the device is in the operative position; the working head assembly is located within a body lumen of the patient adjacent to a portion of tissue to be treated, the working head assembly including a tissue stapling mechanism including first and second tissue stapling members moveable relative to one another in combination with a first cable extending from the actuator through the flexible sheath to the first tissue stapling member so that, when the actuator is operated to draw the first cable proximally from the sheath, the first tissue stapling member is moved in a first direction relative to the second tissue stapling member.

Description

全層切除処置には、臓器の一部の全層を摘出すること、摘出によってできた穴を塞ぐこと、余分な組織を除去することを伴う。   A full-thickness resection procedure involves removing a full thickness of part of an organ, closing a hole created by the removal, and removing excess tissue.

様々な既存の全層切除装置及び処置は、内科医が臓器部位へアクセスし、装置を導くことを可能とするために、切除する臓器の近くで少なくとも一度、切開を要する。当業者は、切除処置に伴うこの切開が実質的に患者に不快感を与え、回復する時間を更に要することを理解する。   Various existing full thickness ablation devices and procedures require an incision at least once near the organ to be excised to allow the physician to access the organ site and guide the device. Those skilled in the art will appreciate that this incision associated with the ablation procedure is substantially uncomfortable for the patient and requires more time to recover.

(発明の要約)
本発明は、作動装置を含む制御ハンドルからなる全層切除装置であり、該装置が患者のボディ・ルーメン内で作動位置にある時、制御ハンドルは患者の体外にありワーキング・ヘッド・アセンブリは柔軟な覆いで制御ハンドルに接続され、装置が作動位置にある時、ワーキング・ヘッド・アセンブリは、治療される組織部位に隣接する患者のボディ・ルーメン内に配され、覆いを介して作動装置から第1組織ステープリング部材へ延長される第1トランスミッション部材と関連して互いに移動可能である第1及び第2組織ステープリング部材を含み、組織ステープリング装置を含むワーキング・ヘッド・アセンブリは、トランスミッション部材が操作される時、第1組織ステープリング部材が第2組織ステープリング部材に関連して第1方向へ移動する。
(Summary of the Invention)
The present invention is a full-thickness ablation device comprising a control handle including an actuating device, wherein the control handle is outside the patient's body and the working head assembly is flexible when the device is in the actuated position within the patient's body lumen. When the device is in the operative position with a protective covering and the device is in the activated position, the working head assembly is disposed within the patient's body lumen adjacent to the tissue site to be treated, and is connected to the actuator through the covering. A working head assembly including first and second tissue stapling members movable relative to each other in relation to a first transmission member extended to a tissue stapling member, wherein the transmission member includes When operated, the first tissue stapling member is in a first direction relative to the second tissue stapling member. Moving.

本発明は、2000年10月25日に出願された、発明の名称が「Method and Device for Full Thickness Resectioning of an Organ」である米国特許出願第09/694,894号と実質的に類似する多くの特徴を含むボディ・ルーメンの組織の全層切除のためのシステムからなり、前記特許は本明細書中「894出願」の表記で、参照として組み入れられる。
当業者は、下記のワーキング・ヘッド・アセンブリ2が、以下で特に詳細に記載する特徴を除いて「894出願」に記載される実施形態と実質的に一致して構成されることを理解する。
以下記載される各実施形態は、組織ステープリング器具の駆動装置を囲むために必要とされるワーキング・ヘッド・アセンブリの長さを縮小する。
The present invention is substantially similar to US patent application Ser. No. 09 / 694,894, filed Oct. 25, 2000, whose title is “Method and Device for Full Thickness Resectioning of an Organ”. A system for full-thickness resection of body lumen tissue, including the following features: the patent is hereby incorporated by reference under the designation “894 Application”.
Those skilled in the art will appreciate that the following working head assembly 2 is configured substantially in accordance with the embodiment described in the “894 Application” except for the features described in greater detail below.
Each of the embodiments described below reduces the length of the working head assembly required to enclose the drive device of the tissue stapling instrument.

図1から図3に示されるように、本発明の第1実施形態の器具は、ワーキング・ヘッド・アセンブリ2からなり、該ワーキング・ヘッド・アセンブリは好ましくは覆い4の遠端4aに接続される。覆い4の近端4bは、好ましくは、手術の間患者の体外にある制御ハンドル6に接続される。   As shown in FIGS. 1 to 3, the instrument of the first embodiment of the present invention comprises a working head assembly 2, which is preferably connected to the distal end 4 a of the cover 4. . The proximal end 4b of the cover 4 is preferably connected to a control handle 6 that is outside the patient's body during surgery.

手術中、図1及び図2に示すように装置全体は、制御ハンドル6、覆い4を通る内視鏡8を通すことで該内視鏡に取り付けられ、ワーキング・ヘッド・アセンブリ2において、該内視鏡は通路9を通る。
次に内視鏡8は、臓器の病斑を目視観測するように位置するために、ボディ・オリフィスを介して臓器に挿入される(通常は臓器を吸入する)。臓器は、例えば実質的に大腸のような管状の組織であることもある。一度病斑の位置を確認したならば、ワーキング・ヘッド・アセンブリ2及び覆い4は、病斑に隣接する望ましい場所に位置するまで、臓器内を内視鏡8に沿ってスライド可能なように前進する。
当業者は本発明の装置はまた、外科処置で作られる開口部を介してボディ・ルーメンに挿入することが可能である事を理解する。
During the operation, as shown in FIGS. 1 and 2, the entire device is attached to the endoscope by passing the endoscope 8 through the control handle 6 and the cover 4, and the working head assembly 2 The endoscope passes through the passage 9.
Next, the endoscope 8 is inserted into the organ through the body orifice (usually inhaling the organ) in order to be positioned so as to visually observe the lesion of the organ. The organ may be a tubular tissue, such as a substantially large intestine. Once the location of the lesion is confirmed, the working head assembly 2 and the cover 4 are slidably moved along the endoscope 8 in the organ until it is located at a desired location adjacent to the lesion. To do.
Those skilled in the art will appreciate that the device of the present invention can also be inserted into the body lumen through an opening made in a surgical procedure.

図2に示される通り、ワーキング・ヘッド・アセンブリ2は、ハウジングの近端12bに接続される近接カップ14と共に、ハウジング12の遠端12aに接続される台部材10からなる。ステープル発射装置16は、遠端12aに取り付けられ、該発射装置から発射されるステープルは、台部材10に近い側面でステープル成形面10aに導かれる。
当業者は、いくつものワーキング・ヘッド・アセンブリ及び台の形状は、特定の適用のために組織のステープリング及び切断に望ましい形状に合せて採用することができることを理解する。
As shown in FIG. 2, the working head assembly 2 comprises a base member 10 connected to the distal end 12a of the housing 12 with a proximity cup 14 connected to the proximal end 12b of the housing. The staple firing device 16 is attached to the distal end 12 a, and the staples fired from the firing device are guided to the staple forming surface 10 a on the side surface close to the base member 10.
Those skilled in the art will appreciate that any number of working head assemblies and platform shapes can be employed to suit the desired shape for tissue stapling and cutting for a particular application.

駆動装置(以下、より詳細に記載される)は、所定の組織を受け入れる距離で、台部材10が遠端12aから分離される第1位置と、該組織を受け入れる距離よりも短い、望ましいステープリング距離で台部材10が遠端12aから分離される第2位置の間を、ステープル発射装置16と関連して台部材10を移動する。
当業者は、装置のボディ・ルーメンへの挿入及び該装置のボディ・ルーメンからの撤収のために、駆動装置は、遠端12aに関連して台部材10を完全に閉止する位置まで移動することが可能であり、該台部材10に近い側面は、遠端12aと接触することを理解する。
本発明の駆動装置は、ワーキング・ヘッド・アセンブリ2の軸長を縮小することが可能であり、従って装置の可動性を改良し、より大きな、可動性が小さいFTRD装置では届かない領域で装置を利用する事を可能とする。
The drive device (described in more detail below) is a desired stapling that is less than a first position where the platform member 10 is separated from the distal end 12a at a distance to receive a predetermined tissue and a distance to receive the tissue. The table member 10 is moved in relation to the staple firing device 16 between a second position at which the table member 10 is separated from the far end 12a.
Those skilled in the art will recognize that the drive moves to a position that fully closes the platform member 10 relative to the distal end 12a for insertion into and removal from the body lumen of the device. It is understood that the side surface close to the base member 10 contacts the far end 12a.
The drive device of the present invention is capable of reducing the axial length of the working head assembly 2, thus improving the mobility of the device and allowing the device to be reached in areas not reachable by larger, less mobile FTRD devices. It can be used.

特に図2で示される通り、台部材10が組織を受け入れる位置にある時、操作者が病斑を切除のために引き出すことを可能とする、十分に大きな隙間により、台部材10は遠端12aから分離される。切除される組織が台部材10と遠端12aの間の隙間の方に引き出される時、操作者は台部材10を望むステープリング位置へ移動するために駆動装置を作動させ、隙間により台部材10は遠端12aから分離され、該隙間の大きさは用いられるステープルの特徴に基づいて選択され、ステープルは操作者の望ましい形状に形成される。
従って、当業者は隙間の大きさが特定の適用に応じて変化し、装置は既存のステープル調整装置を利用する操作者により設計、又は調整が可能であることを理解する。図3a、図3bに示される他の実施形態において、最小の隙間の大きさは、ショルダー部材12cで制御され、該ショルダー部材は遠端12aから離れて突出する。
従って、台部材10が接近すると、表面10aを形成するステープルと遠端12aの間隔が望ましいステープリング間隔の時、該台部材の近接面はショルダー部材12cと接触する。この場合、ステープリング位置は完全に閉止した位置と同じである。
In particular, as shown in FIG. 2, when the pedestal member 10 is in a position to receive tissue, the pedestal member 10 has a far end 12a due to a sufficiently large gap that allows the operator to withdraw the lesion for excision. Separated from. When the tissue to be excised is pulled toward the gap between the platform member 10 and the distal end 12a, the operator operates the drive device to move the platform member 10 to the desired stapling position, and the platform member 10 is driven by the gap. Is separated from the distal end 12a, and the size of the gap is selected based on the characteristics of the staple used, and the staple is formed into the desired shape of the operator.
Accordingly, those skilled in the art will appreciate that the size of the gap will vary depending on the particular application, and that the device can be designed or adjusted by an operator utilizing an existing staple adjustment device. In another embodiment shown in FIGS. 3a and 3b, the minimum gap size is controlled by a shoulder member 12c that projects away from the far end 12a.
Accordingly, when the base member 10 approaches, the proximal surface of the base member comes into contact with the shoulder member 12c when the desired stapling interval is the distance between the staple forming the surface 10a and the far end 12a. In this case, the stapling position is the same as the fully closed position.

図2、図3a及び図3bに示されるように、第1実施形態の台部材10は、2本の取付軸28でハウジング12に接続され、該取付軸は、対応する取付軸通路30を通してスライド可能なように受け入れられる。
各軸28は延長される中央通路32を含み、その結果、圧縮スプリング34が、隣接して対応する、各軸通路30の近端に取り付けられるスプリング止め36の内部に受け入れられる。各スプリング34の遠端は、対応する中央通路32の遠端で内面に隣接する。
従って、圧縮スプリング34は台部材10を、ハウジング12の遠端12aから離れて一方に偏らせる。当業者は、中央通路32及びスプリング34の長さが、解放された時に台部材10が、少なくとも望んだ組織を受け入れる隙間と等しい距離を、遠端からスプリング34により離れて移動するように選択されることを理解する。
更に、図3c及び図3dに示されるように、台部材10が望んだ組織を受け入れる最大の隙間を越えて遠端12aから離れるのを防ぐため、ハウジング内でスプリング34に対応する軸通路30に向かって該スプリングに延びて対応する停止面40に接触するために、隣接する表面38を軸28の一方又は両方に形成することができる。
As shown in FIGS. 2, 3 a and 3 b, the base member 10 of the first embodiment is connected to the housing 12 by two mounting shafts 28, and the mounting shafts slide through corresponding mounting shaft passages 30. Accepted as possible.
Each shaft 28 includes an extended central passage 32 so that a compression spring 34 is received within an adjacent, corresponding spring stop 36 attached to the proximal end of each shaft passage 30. The distal end of each spring 34 is adjacent to the inner surface at the distal end of the corresponding central passage 32.
Accordingly, the compression spring 34 biases the base member 10 away from the far end 12a of the housing 12 to one side. One skilled in the art will select the length of the central passage 32 and the spring 34 such that when released, the platform member 10 moves away from the distal end by the spring 34 a distance at least equal to the gap for receiving the desired tissue. I understand that.
Further, as shown in FIGS. 3c and 3d, in order to prevent the base member 10 from moving away from the distal end 12a beyond the maximum clearance for receiving the desired tissue, the shaft passage 30 corresponding to the spring 34 in the housing Adjacent surfaces 38 can be formed on one or both of the shafts 28 to extend toward the springs and contact the corresponding stop surfaces 40.

台制御ケーブル42は、軸28の最初の1本の遠端から延びてループ状に形成され、該ループは対応する軸通路30及び中央通路32を貫通し、制御ハンドル6へ、覆い4を離れて通過するために覆い4の近くへワーキング・ヘッド・アセンブリ2を貫通して接続される。
ケーブル42のループは、軸28の遠端に接続するために対応軸通路30及び中央通路32を介して、ワーキング・ヘッド・アセンブリ2へ覆い4とは逆向きに延長される。
具体的には、台制御ケーブル42は台部材10に接続される制御軸28の各遠端に接続され、制御ハンドル6内の覆い4を貫通し、制御ケーブル作動装置(図示せず)を通るループとして通過する。
従って、制御ケーブル作動装置を作動することは、台制御ケーブル42のループを近くに引き、スプリング34の偏りに対する遠端12aに関連して台部材10を近くに引き寄せる。当業者は代わりに台制御ケーブル42のループが2本の分離したケーブル、又は同じ作動を行うための1本のケーブルとして形成されることを理解する。
更に当業者は望めば、台部材10が1本の軸28でハウジング12に接続されることを理解する。しかしながら、そのような設計は剛性を減少することがある。
The pedestal control cable 42 extends from the first distal end of the shaft 28 and is formed in a loop that passes through the corresponding shaft passage 30 and central passage 32 and leaves the cover 4 to the control handle 6. Is connected through the working head assembly 2 close to the cover 4 for passing through.
The loop of the cable 42 is extended in the opposite direction to the cover 4 to the working head assembly 2 via the corresponding shaft passage 30 and the central passage 32 for connection to the far end of the shaft 28.
Specifically, the pedestal control cable 42 is connected to each distal end of the control shaft 28 connected to the pedestal member 10, passes through the cover 4 in the control handle 6, and passes through a control cable operating device (not shown). Pass as a loop.
Thus, activating the control cable actuator pulls the loop of the pedestal control cable 42 closer and pulls the pedestal member 10 closer relative to the distal end 12a against the bias of the spring 34. Those skilled in the art will appreciate that the loop of the pedestal control cable 42 is instead formed as two separate cables or one cable for performing the same operation.
Further, those skilled in the art will appreciate that the base member 10 is connected to the housing 12 by a single shaft 28 if desired. However, such a design may reduce stiffness.

従って、装置の近くからケーブル42を引き出すために制御ケーブル作動装置を作動し、一方ワーキング・ヘッド・アセンブリ2の位置を常に維持することは、ハウジング12の遠端12aの方へ台部材10の近くで引き出す。
当業者は軸通路30、中央通路32、ガイド軸30及びスプリング34の長さは、制御ケーブル42が最大の間隔に近い状態で引き出され、望んだ組織をステープリングする距離と等しい距離で台部材10及び遠端12aが分離されるまで、遠端12aの方へスプリング34に対して、台部材10が動かされるように選択されることを理解する。
代わりに、上記のようにこれら要素は、台部材10及びショルダー部材12cが互いに接触するまで(例えば、装置を挿入及び撤収するために完全に閉止した状態)、遠端12aの方へ引き出されるように設計される。
上記したように、この実施形態において、ステープリング位置と完全に閉止した位置は同じである。図2、図3a及び図3bで示されるように、ショルダー部材12cの厚さが、ステープリングの隙間のサイズを決める。
例えば、約0.070インチの隙間が採用される。しかしながら、当業者に理解されるように、(例えば、スプリング止め36を調節することにより)装置に隣接している分離する隙間を採用することができる。
更に当業者に理解されるように、ユーザは望んだ位置でケーブル42のロックを可能とし、台部材10及び遠端12aの望んだ幅での分離を保てるようにするために、制御ケーブル作動装置にロック装置(図示せず)を含むことも可能である。
Thus, operating the control cable actuator to pull the cable 42 from near the device, while always maintaining the position of the working head assembly 2, is near the platform member 10 toward the distal end 12a of the housing 12. Pull out with.
Those skilled in the art will appreciate that the length of the shaft passage 30, the center passage 32, the guide shaft 30 and the spring 34 is the same length as the distance that the control cable 42 is pulled out with the maximum spacing and stapling the desired tissue. It will be appreciated that the base member 10 is selected to be moved relative to the spring 34 toward the far end 12a until the 10 and the far end 12a are separated.
Instead, as described above, these elements are pulled toward the distal end 12a until the pedestal member 10 and shoulder member 12c contact each other (eg, fully closed to insert and withdraw the device). Designed to.
As described above, in this embodiment, the stapling position and the fully closed position are the same. As shown in FIGS. 2, 3a and 3b, the thickness of the shoulder member 12c determines the size of the stapling gap.
For example, a gap of about 0.070 inches is employed. However, as will be appreciated by those skilled in the art, a separate gap adjacent to the device can be employed (eg, by adjusting the spring stop 36).
As will be further appreciated by those skilled in the art, the control cable actuator can be used to allow the user to lock the cable 42 in the desired position and to maintain the desired width separation of the platform member 10 and the distal end 12a. It is also possible to include a locking device (not shown).

圧縮スプリング34は、好ましくはステンレス鋼(例えば、ミュージック・ワイヤー)で形成され、制御ケーブルの作動装置の解放において、台部材10の、望んだ組織の受け入れを確実にし、例えば、軸28及び/又はケーブル42の先端での移動を妨害する任意の抵抗を克服するための十分な偏り力を供給する。
例えば、総合力は約8から12ポンドであり、より好ましくは約10ポンドであり、0.75インチの組織を受け入れるのに十分である。従って、台部材10が組織ステープリング位置にある時、各スプリング34は、5ポンドの力がスプリング止め36と中央通路の遠端の間に適用される位置へ圧縮される。
スプリング34として用いるのに適切なスプリングは、例えば、市販のLee Spring LC-023-AB-14のような0.15インチの直径、1.50インチの自由長さのミュージック・ワイヤー・コイル・スプリングからなる。
The compression spring 34 is preferably formed of stainless steel (eg, music wire) to ensure receipt of the desired tissue of the platform member 10 upon release of the control cable actuator, eg, the shaft 28 and / or Provide sufficient biasing force to overcome any resistance that impedes movement at the tip of cable 42.
For example, the total force is about 8 to 12 pounds, more preferably about 10 pounds, sufficient to accept 0.75 inches of tissue. Thus, when the pedestal member 10 is in the tissue stapling position, each spring 34 is compressed into a position where a 5 pound force is applied between the spring stop 36 and the distal end of the central passage.
A suitable spring for use as the spring 34 is a 0.15 inch diameter, 1.50 inch free length music wire coil spring, such as the commercially available Lee Spring LC-023-AB-14. Consists of.

図4、図5a及び図5bに示されるように、本発明の第2実施形態のワーキング・ヘッド・アセンブリ2’は、下記の駆動装置を除いて前記実施形態と実質的に類似する。
ワーキング・ヘッド・アセンブリ2’は、該ワーキング・ヘッド・アセンブリの遠端12aに、上記図1から図3に対応する軸通路30内でワーキング・ヘッド・アセンブリ2’に受け入れられる2本の軸28で接続される台部材10を含む。
しかしながら、この実施形態において制御ケーブル・ループ46は、例えばネジ49で軸28に接続され、図1から図3に示される上記実施形態の制御ケーブル42に関連して、覆い4を貫通して制御ケーブル作動装置(図示せず)に延長される。
各制御ケーブル・ループ46は、下記に詳述するように、ワーキング・ヘッド・アセンブリ2’及び覆い4を制御ケーブル作動装置へ逆に移動させる滑車52の周りを、ネジ49から、対応する軸28を貫通して延長される。
各ケーブル・ループ46の端部は、対応する軸28へ接続するために、近接キャップ14及びケーブル・ルーティング・プレート51を通過する。
As shown in FIGS. 4, 5 a and 5 b, the working head assembly 2 ′ of the second embodiment of the present invention is substantially similar to the above embodiment except for the following driving device.
The working head assembly 2 'has two shafts 28 that are received by the working head assembly 2' at the distal end 12a of the working head assembly in an axial passage 30 corresponding to FIGS. It includes a base member 10 connected at
However, in this embodiment, the control cable loop 46 is connected to the shaft 28 with, for example, a screw 49 and is controlled through the cover 4 in connection with the control cable 42 of the above embodiment shown in FIGS. It is extended to a cable actuator (not shown).
Each control cable loop 46 extends from a screw 49 to a corresponding shaft 28 around a pulley 52 that moves the working head assembly 2 'and cover 4 back to the control cable actuator, as will be described in detail below. Is extended through.
The end of each cable loop 46 passes through the proximity cap 14 and the cable routing plate 51 for connection to the corresponding shaft 28.

図5a及び図5bに示されるように、制御ケーブル46は制御ケーブル作動装置(図示せず)から覆い4を、ワーキング・ヘッド・アセンブリ2’を貫通して延長され、ネジ49で軸28に接続される。制御ケーブル46はネジ49から軸28の外側に延長され、ワーキング・ヘッド・アセンブリ2’の外側を通過するために滑車52の周りを通過し、覆い4から制御ケーブル作動装置へ貫通する。
当業者に理解されるように、制御ケーブル作動装置は、作動装置が操作される時、滑車52の反対側のケーブル46の一部分が反対方向に移動するように設計される。各滑車52はポイントを離れて配され、ケーブル46は、制御ケーブルが移動する時に軸28から出て、ケーブル46はネジ49及び軸28を近くへ引き出し、台部材10はハウジング12の遠端12aに向かい、近くに移動する。
反対方向に制御ケーブル作動装置を操作することは、離れて制御ケーブル46及び対応するネジ49を引き出し、軸28及び台部材10が遠端12aから離れて移動するようにする。
As shown in FIGS. 5 a and 5 b, the control cable 46 extends from the control cable actuator (not shown) through the cover 4, through the working head assembly 2 ′, and is connected to the shaft 28 with screws 49. Is done. The control cable 46 extends from the screw 49 to the outside of the shaft 28, passes around the pulley 52 to pass outside the working head assembly 2 ', and passes from the cover 4 to the control cable actuator.
As will be appreciated by those skilled in the art, the control cable actuator is designed such that a portion of the cable 46 opposite the pulley 52 moves in the opposite direction when the actuator is operated. Each pulley 52 is spaced apart and the cable 46 exits the shaft 28 as the control cable moves, the cable 46 pulls the screw 49 and shaft 28 closer together, and the platform member 10 is the distal end 12a of the housing 12. Go to and move closer.
Operating the control cable actuator in the opposite direction pulls away the control cable 46 and the corresponding screw 49 so that the shaft 28 and the platform member 10 move away from the far end 12a.

図6に示されるように、本発明の第3実施形態のワーキング・ヘッド・アセンブリ2”は、ハウジング12の遠端12aに関連して台部材10を移動するための駆動装置を除いて前記実施形態に実質的に類似する。
具体的には、ワーキング・ヘッド・アセンブリ2”の駆動装置は、軸方向に柔軟であり、実質的に捩れに対して柔軟性がない駆動軸60を含み、該駆動軸は孔の開いた遠端60aを含み、該遠端は接合糸を第1軸28’に延長される通路64に通す。
第1軸28’は、ヨーク部材で第2軸28”に接続される。第1軸28’は、ハウジング12に関連する回転が、例えば、それぞれ軸通路30に切り欠けが適合する軸28’の突起により妨げられる。
従って、駆動軸60が第1軸28’に関連する第1方向において回転するにつれ、第1軸28’、ヨーク部材66及び第2軸28”はハウジング12へ離れて進み、台部材10は、遠端12aから離れて移動する。
駆動軸60が第1方向とは反対の第2方向に回転する時、第1軸28’、ヨーク部材66及び第2軸28”は、ハウジング12の近くに引き出され、台部材10は遠端12aの方向に引き寄せられる。
As shown in FIG. 6, the working head assembly 2 ″ of the third embodiment of the present invention is the same as that described above except for the driving device for moving the base member 10 in relation to the distal end 12a of the housing 12. Substantially similar in form.
In particular, the drive device of the working head assembly 2 ″ includes a drive shaft 60 that is axially flexible and substantially inflexible to torsion, the drive shaft being a perforated far end. Including the end 60a, the far end passes the joining thread through a passage 64 that extends to the first shaft 28 '.
The first shaft 28 ′ is connected to the second shaft 28 ″ with a yoke member. The first shaft 28 ′ is a shaft 28 ′ in which the rotation associated with the housing 12 is fitted, for example, with a notch in the shaft passage 30, respectively. It is obstructed by the protrusions.
Thus, as the drive shaft 60 rotates in the first direction relative to the first shaft 28 ', the first shaft 28', the yoke member 66 and the second shaft 28 "move away to the housing 12, and the platform member 10 is Move away from the far end 12a.
When the drive shaft 60 rotates in the second direction opposite to the first direction, the first shaft 28 ′, the yoke member 66 and the second shaft 28 ″ are pulled out near the housing 12, and the base member 10 is at the far end. It is drawn in the direction of 12a.

図7は、本発明の駆動装置の第4実施形態を示し、該実施形態はハウジング12の遠端12aに関連する台部材10を移動するための駆動装置を除いて前記実施形態に実質的に類似する。図7の駆動装置は、例えば、取り付けられるネジ部材(図示せず)を有する駆動軸60を含む。
ネジ部材は、共に回転するためのアイドラー・ギア72内に受け入れられる。アイドラー・ギア72は軸76を回転するためにギア74と噛み合わせる。各軸76は、ネジが形成された端部76aを含み、該端部は軸28の通路内で結合される(上記した、軸28’とネジ部60aのように)。
従って、駆動軸60の回転の際に、アイドラー・ギア72は、軸28及び台部材10をハウジング12の遠端12aに向けて行き来するためにギア74、軸76及びスレッド部76aを回転する。
FIG. 7 shows a fourth embodiment of the drive device of the present invention, which embodiment is substantially similar to the previous embodiment except for the drive device for moving the base member 10 associated with the distal end 12 a of the housing 12. Similar. The drive device of FIG. 7 includes, for example, a drive shaft 60 having a screw member (not shown) to be attached.
The screw member is received in an idler gear 72 for rotation together. Idler gear 72 meshes with gear 74 to rotate shaft 76. Each shaft 76 includes a threaded end 76a that is coupled within the passage of shaft 28 (as described above for shaft 28 'and threaded portion 60a).
Accordingly, when the drive shaft 60 rotates, the idler gear 72 rotates the gear 74, the shaft 76, and the sled portion 76a to move the shaft 28 and the base member 10 back and forth toward the far end 12a of the housing 12.

図8は、本発明の駆動装置の第5実施形態を示し、該実施形態はハウジング12の遠端12aに関連する台部材10を移動するための駆動装置を除いて前記実施形態に実質的に類似する。図8の駆動装置は、例えば、取り付けられるネジ部材(図示せず)を有する駆動軸60を含む。ネジ部材は、共に回転するための第1ギア80内に受け入れられる。
第1ギア80は第2ギア84を回転するためにアイドラー・ギア82と噛み合わせられる。第1ギア80及び第2ギア84の回転は対応する、取り付けられている軸86の内の1本を順番に回転する。各軸86は、ネジが形成された端部86aを含み、該端部は対応する軸28の内の1本の通路内で結合される(上記した、軸28と軸74のように)。
従って、駆動軸60の回転において、ネジ部材はギア80を回転し、その結果、アイドラー・ギア82及び第2ギア84を回転し、台部材10を遠端12a方に行き来するため、該回転は軸28内で軸86及びネジ部86aを回転する。
FIG. 8 shows a fifth embodiment of the drive device of the present invention, which embodiment is substantially similar to the previous embodiment except for the drive device for moving the base member 10 associated with the distal end 12a of the housing 12. FIG. Similar. 8 includes, for example, a drive shaft 60 having a screw member (not shown) to be attached. The screw member is received in a first gear 80 for rotation together.
The first gear 80 meshes with the idler gear 82 to rotate the second gear 84. The rotation of the first gear 80 and the second gear 84 rotates one of the corresponding attached shafts 86 in turn. Each shaft 86 includes a threaded end 86a that is coupled within a passage in the corresponding shaft 28 (as described above for shaft 28 and shaft 74).
Accordingly, in the rotation of the drive shaft 60, the screw member rotates the gear 80. As a result, the idler gear 82 and the second gear 84 are rotated, and the base member 10 is moved back and forth toward the far end 12a. The shaft 86 and the screw portion 86a are rotated within the shaft 28.

上記実施形態は、例示のみを目的としており、今後明らかとなるこれら実施形態の様々な修正は、本発明の技術の範囲内であり、本発明は請求項よってのみ制限される。   The above embodiments are for illustrative purposes only, and various modifications of these embodiments which will become apparent in the future are within the scope of the present invention, and the present invention is limited only by the claims.

本発明の第1実施形態の全層切除装置の斜視図を示す。The perspective view of the full-thickness excision apparatus of 1st Embodiment of this invention is shown. 図1の装置のワーキング・ヘッド・アセンブリの斜視図を示す。Figure 2 shows a perspective view of the working head assembly of the apparatus of Figure 1; 台部材が閉止位置にある図2のワーキング・ヘッド・アセンブリの断面図を示す。FIG. 3 shows a cross-sectional view of the working head assembly of FIG. 2 with the platform member in the closed position. 台部材が開き、組織を受け入れる位置にある、図2のワーキング・ヘッド・アセンブリの断面図を示す。FIG. 3 illustrates a cross-sectional view of the working head assembly of FIG. 2 with the pedestal member open and receiving tissue. 図3a及び図3bの取付軸の側面図を示す。Fig. 4 shows a side view of the mounting shaft of Figs. 3a and 3b. ハウジングの停止面をより詳細に示す、図3a及び図3bのワーキング・ヘッド・アセンブリの断面図の一部分を示す。Fig. 4 shows a portion of a cross-sectional view of the working head assembly of Figs. 本発明の第2実施形態の全層切除装置の斜視図を示す。The perspective view of the full-thickness excision apparatus of 2nd Embodiment of this invention is shown. 台部材が閉止位置にある図4のワーキング・ヘッド・アセンブリの断面図を示す。FIG. 5 shows a cross-sectional view of the working head assembly of FIG. 4 with the platform member in the closed position. 台部材が開き、組織を受け入れる位置にある、図4のワーキング・ヘッド・アセンブリの断面図を示す。FIG. 5 shows a cross-sectional view of the working head assembly of FIG. 4 with the pedestal member open and receiving tissue. 本発明の第3実施形態の全層切除装置の斜視図を示す。The perspective view of the full layer cutting device of 3rd Embodiment of this invention is shown. 本発明の第4実施形態の駆動装置の一部を示す。A part of drive device of a 4th embodiment of the present invention is shown. 本発明の第5実施形態の駆動装置の一部を示す。The drive device of 5th Embodiment of this invention is shown.

Claims (8)

患者のボディ・ルーメン内で作動位置にある時、制御ハンドルが患者の体外にある作動装置を含む制御ハンドルと、
装置が作動位置にある時、治療される組織部位に隣接する患者のボディ・ルーメン内に配され、覆いを介して作動装置から第1組織ステープリング部材へ延長される第1トランスミッション部材に関連して互いが移動可能である第1及び第2組織ステープリング部材を含み、柔軟な覆いで制御ハンドルと接続されるワーキング・ヘッド・アセンブリと、
前記柔軟な覆いを貫通して作動装置から前記第1組織ステープリング部材へ延長され、作動装置が前記覆いから第1ケーブルを近くに引き出すため作動する時、第1組織ステープリング部材が、第2組織ステープリング部材に関連して第1方向へ移動するようにする第1ケーブルと、
第1組織ステープリング部材から制御ハンドルへ延長される第2ケーブルであって、前記覆いから近くに引き出される時、前記第1方向の反対の第2方向において、第1組織ステープリング部材が第2組織ステープリング部材に対して移動する第2ケーブルとを備え外科用装置。
A control handle including an actuating device when the control handle is outside the patient's body when in the operating position within the patient's body lumen;
Associated with a first transmission member disposed in the patient's body lumen adjacent to the tissue site to be treated and extending from the actuator to the first tissue stapling member through a covering when the device is in the activated position. A working head assembly including first and second tissue stapling members movable relative to each other and connected to the control handle with a flexible covering;
The first tissue stapling member is extended through the flexible covering from the actuating device to the first tissue stapling member and when the actuating device is activated to draw the first cable from the covering close to the first tissue stapling member. A first cable adapted to move in a first direction relative to the tissue stapling member;
A second cable extending from the first tissue stapling member to the control handle, wherein the first tissue stapling member is second in a second direction opposite the first direction when pulled proximally from the covering. surgical apparatus Ru and a second cable to move relative to the tissue stapling member.
力が第1ケーブルに適用されない時、第1組織ステープリング部材が第2組織ステープリング部材に関連して第2方向に動かされるように、前記第1方向の反対の第2方向に第2組織ステープリング部材に関連して前記第1組織ステープリング部材を動かす弾性部材から更になる請求項1の装置。When a force is not applied to the first cable, the second tissue in a second direction opposite the first direction so that the first tissue stapling member is moved in the second direction relative to the second tissue stapling member. The apparatus of claim 1, further comprising an elastic member that moves the first tissue stapling member relative to the stapling member. 第1組織ステープリング部材が台部材であり、第2組織ステープリング部材がステープル発射装置である請求項の装置。The apparatus of claim 2 , wherein the first tissue stapling member is a pedestal member and the second tissue stapling member is a staple firing device. 前記台がスライド可能なようにワーキング・ヘッド・アセンブリに接続される軸に取り付けられ、弾性部材が軸と前記ワーキング・ヘッド・アセンブリの間で接続されるバネであることを特徴とする請求項の装置。Claim 3 wherein the platform is attached to a shaft which is connected to the working head assembly to allow the slide, the resilient member being a spring connected between said working head assembly and axial Equipment. 前記第1組織ステープリング部材が台であり、前記第2組織ステープリング部材がステープル発射装置であり、前記第2ケーブルが前記台に接続するために滑車の周りを延長され、前記第2ケーブルが覆いの近くに引き出される時、前記台はステープル発射装置と相対的に離れて動かされる、請求項の装置。The first tissue stapling member is a pedestal, the second tissue stapling member is a staple firing device, the second cable is extended around a pulley to connect to the pedestal, and the second cable is when drawn near the cover, it said platform is moved away relative to the staple firing system, apparatus according to claim 1. 前記台がワーキング・ヘッド・アセンブリにスライド可能なように軸に取り付けられ、第2ケーブルが軸に接続されることを特徴とする請求項の装置。6. The apparatus of claim 5 , wherein the platform is slidably mounted on the shaft to the working head assembly and a second cable is connected to the shaft. ワーキング・ヘッド・アセンブリ内で、前記台が軸にスライド可能なように受け入れられて接続され、前記第1ケーブルが軸の遠端から覆いを貫通し作動装置へ延長され、覆いから近くへの第1ケーブルの引き出しは、ステープル発射装置と相対的に、台を近くに引き出すようにすることを特徴とする請求項の装置。Within the working head assembly, the platform is slidably received and connected to the shaft, and the first cable extends from the distal end of the shaft through the cover to the actuator, and the first cable from the cover to the vicinity. 6. The apparatus of claim 5 , wherein the pulling of one cable causes the platform to be pulled closer relative to the staple firing device. 操作者が第1及び第2組織ステープリング部材を、互いが望ましい位置においてロックすることを可能とする制御ハンドルのロッキング部材から更になる請求項1の装置。The apparatus of claim 1, further comprising a locking member of the control handle that allows an operator to lock the first and second tissue stapling members in a desired position relative to each other.
JP2004506666A 2002-05-24 2003-04-28 Full thickness ablation device Expired - Lifetime JP4361859B2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/156,293 US6685079B2 (en) 2002-05-24 2002-05-24 Full thickness resectioning device
PCT/US2003/013304 WO2003099138A2 (en) 2002-05-24 2003-04-28 Full thickness resectioning device

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Publication Number Publication Date
JP2005526568A JP2005526568A (en) 2005-09-08
JP4361859B2 true JP4361859B2 (en) 2009-11-11

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Families Citing this family (194)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1377222B1 (en) 2001-04-03 2011-10-19 Tyco Healthcare Group LP Surgical stapling device
US20070060952A1 (en) * 2005-09-02 2007-03-15 Roby Mark S Surgical stapling device with coated knife blade
EP2452636B1 (en) * 2001-10-05 2016-03-23 Covidien LP Surgical stapling apparatus
MXPA04003176A (en) * 2001-10-05 2004-07-08 Tyco Healthcare Tilt top anvil for a surgical fastener device.
US7261722B2 (en) * 2001-12-20 2007-08-28 Rex Medical, L.P. Apparatus and method for treating gastroesophageal reflux disease
US6685079B2 (en) * 2002-05-24 2004-02-03 Scimed Life Systems, Inc. Full thickness resectioning device
EP1572250B1 (en) 2002-07-31 2011-04-27 Tyco Healthcare Group LP Tool member cover and cover deployment device
WO2004032766A2 (en) 2002-10-04 2004-04-22 Tyco Healthcare Group Lp Surgical stapling device
WO2004112583A2 (en) * 2003-06-20 2004-12-29 Tyco Healthcare Group, Lp Surgical stapling device
US6959851B2 (en) * 2003-07-16 2005-11-01 Tyco Healthcare Group Lp Surgical stapling device with tissue tensioner
EP1680028B1 (en) 2003-10-17 2012-01-25 Tyco Healthcare Group LP Surgical stapling device
US8100822B2 (en) 2004-03-16 2012-01-24 Macroplata Systems, Llc Anoscope for treating hemorrhoids without the trauma of cutting or the use of an endoscope
US8181840B2 (en) 2004-03-19 2012-05-22 Tyco Healthcare Group Lp Tissue tensioner assembly and approximation mechanism for surgical stapling device
WO2005091986A2 (en) 2004-03-19 2005-10-06 Tyco Healthcare Group, Lp Anvil assembly with improved cut ring
US11291443B2 (en) * 2005-06-03 2022-04-05 Covidien Lp Surgical stapler with timer and feedback display
US7892244B2 (en) * 2006-03-09 2011-02-22 Niti Surgical Solutions Ltd. Surgical compression clips
US7635374B2 (en) * 2006-03-09 2009-12-22 Niti Surgical Solutions Ltd. Endoscopic full thickness resection using surgical compression clips
US8540132B2 (en) 2006-05-16 2013-09-24 Covidien Lp Tilt anvil assembly
ATE499048T1 (en) 2007-03-07 2011-03-15 Covidien Ag CLAPPER FOR MUCOSECTOMY
CA2691269C (en) * 2007-05-12 2016-04-12 Barosense, Inc. Devices and methods for stomach partitioning
US8011554B2 (en) 2008-01-09 2011-09-06 Tyco Healthcare Group, Lp Raised boss for staple guide
US8181838B2 (en) 2008-09-10 2012-05-22 Tyco Healthcare Group Lp Surgical stapling device
US8231042B2 (en) 2008-11-06 2012-07-31 Tyco Healthcare Group Lp Surgical stapler
US8281974B2 (en) 2009-01-14 2012-10-09 Tyco Healthcare, Group LP Surgical stapler with suture locator
US8453913B2 (en) 2009-02-06 2013-06-04 Covidien Lp Anvil for surgical stapler
US8827134B2 (en) 2009-06-19 2014-09-09 Covidien Lp Flexible surgical stapler with motor in the head
US8146790B2 (en) 2009-07-11 2012-04-03 Tyco Healthcare Group Lp Surgical instrument with safety mechanism
US8267301B2 (en) 2009-08-19 2012-09-18 Tyco Healthcare Group Lp Surgical stapler
WO2011041578A2 (en) * 2009-10-01 2011-04-07 Macroplata, Inc. Detachable balloon catheter
US8322590B2 (en) 2009-10-28 2012-12-04 Covidien Lp Surgical stapling instrument
US8430292B2 (en) 2009-10-28 2013-04-30 Covidien Lp Surgical fastening apparatus
US10531869B2 (en) 2009-12-16 2020-01-14 Boston Scientific Scimed, Inc. Tissue retractor for minimally invasive surgery
CA2783252A1 (en) 2009-12-16 2011-07-14 Macroplata Inc. A substantially rigid and stable endoluminal surgical suite for treating a gastrointestinal lesion
US8932211B2 (en) 2012-06-22 2015-01-13 Macroplata, Inc. Floating, multi-lumen-catheter retractor system for a minimally-invasive, operative gastrointestinal treatment
US10595711B2 (en) 2009-12-16 2020-03-24 Boston Scientific Scimed, Inc. System for a minimally-invasive, operative gastrointestinal treatment
US9565998B2 (en) 2009-12-16 2017-02-14 Boston Scientific Scimed, Inc. Multi-lumen-catheter retractor system for a minimally-invasive, operative gastrointestinal treatment
US10966701B2 (en) 2009-12-16 2021-04-06 Boston Scientific Scimed, Inc. Tissue retractor for minimally invasive surgery
US9186131B2 (en) 2009-12-16 2015-11-17 Macroplata, Inc. Multi-lumen-catheter retractor system for a minimally-invasive, operative gastrointestinal treatment
US10758116B2 (en) 2009-12-16 2020-09-01 Boston Scientific Scimed, Inc. System for a minimally-invasive, operative gastrointestinal treatment
USRE48850E1 (en) 2009-12-16 2021-12-14 Boston Scientific Scimed, Inc. Multi-lumen-catheter retractor system for a minimally-invasive, operative gastrointestinal treatment
CN105534566B (en) 2010-04-26 2019-11-05 科维迪恩公司 For influencing the device and method of at least one anatomical structure
US8632458B2 (en) 2011-10-26 2014-01-21 Macroplata Inc. Gentle hemorrhoid treatment offering a substantially painless healing
US8708212B2 (en) 2011-10-18 2014-04-29 Covidien Lp Tilt top anvil with torsion spring
US9016547B2 (en) 2011-10-26 2015-04-28 Covidien Lp EEA tilt top anvil with ratchet/locking mechanism
US9010605B2 (en) 2012-01-12 2015-04-21 Covidien Lp Sliding sleeve for circular stapling instrument reloads
US9022274B2 (en) 2012-02-15 2015-05-05 Covidien Lp Circular stapler with increased lumen diameter
US9351734B2 (en) 2012-06-19 2016-05-31 Covidien Lp Spring loaded anvil retainer
US10213205B2 (en) 2012-07-06 2019-02-26 Covidien Lp T-slot tilt anvil for circular stapling instrument
US9675359B2 (en) 2012-10-10 2017-06-13 Covidien Lp Surgical instrument with preload assembly
US9572572B2 (en) 2012-11-09 2017-02-21 Covidien Lp Circular stapler mechanical lockout
US9351724B2 (en) 2013-01-11 2016-05-31 Covidien Lp Circular stapling instrument
US9592056B2 (en) 2013-03-14 2017-03-14 Covidien Lp Powered stapling apparatus
CN104042292A (en) 2013-03-15 2014-09-17 柯惠Lp公司 Surgical anastomosis device comprising assemblies capable of being repeatedly utilized
US9532780B2 (en) 2013-06-12 2017-01-03 Covidien Lp EEA anvil snap ring activator
US9668740B2 (en) 2013-06-14 2017-06-06 Covidien Lp Anvil assembly with sliding sleeve
AU2013393223B2 (en) 2013-06-17 2018-10-25 Covidien Lp Surgical instrument with lockout mechanism
US9750503B2 (en) 2013-07-11 2017-09-05 Covidien Lp Methods and devices for performing a surgical anastomosis
US9693773B2 (en) 2013-09-11 2017-07-04 Covidien Lp Anvil assembly with sliding sleeve
US9517070B2 (en) 2013-11-13 2016-12-13 Covidien Lp Anvil assembly and delivery system
US9554802B2 (en) 2013-11-13 2017-01-31 Covidien Lp Anvil assembly with frangible retaining member
US9913643B2 (en) 2014-05-09 2018-03-13 Covidien Lp Interlock assemblies for replaceable loading unit
WO2015188347A1 (en) 2014-06-12 2015-12-17 Covidien Lp Surgical stapling apparatus
US9867619B2 (en) 2014-06-24 2018-01-16 Covidien Lp System for delivering an anvil assembly to a surgical site
US9861367B2 (en) 2014-06-24 2018-01-09 Covidien Lp Anvil assembly delivery systems
CN106659502B (en) 2014-07-04 2019-03-01 柯惠有限合伙公司 The load units with shipment component for surgical stapling device
US9757133B2 (en) 2014-07-09 2017-09-12 Covidien Lp Methods and devices for performing a surgical anastomosis
US10898196B2 (en) 2014-11-21 2021-01-26 Covidien Lp Cleaning apparatus for surgical instruments
US10085744B2 (en) 2014-12-08 2018-10-02 Covidien Lp Loading unit attachment band for surgical stapling instrument
US9855045B2 (en) 2014-12-09 2018-01-02 Covidien Lp Anvil assembly delivery system
WO2016090594A1 (en) 2014-12-11 2016-06-16 Covidien Lp Surgical stapling loading unit
CN107106180B (en) 2014-12-11 2020-04-21 柯惠有限合伙公司 Stapling device with automatic locking mechanism
WO2016095112A1 (en) 2014-12-17 2016-06-23 Covidien Lp Surgical stapling device with firing indicator
US10039549B2 (en) 2015-01-07 2018-08-07 Covidien Lp Loading unit retention clip for surgical stapling instrument
US10022126B2 (en) 2015-01-07 2018-07-17 Covidien Lp Loading unit locking collar
US10117656B2 (en) 2015-01-07 2018-11-06 Covidien Lp Loading unit locking collar
EP3256057B1 (en) 2015-02-15 2021-07-28 Covidien LP Surgical stapling device with firing indicator of unitary construction
US10881408B2 (en) 2015-04-22 2021-01-05 Covidien Lp Interlock assembly for replaceable loading units
US10426480B2 (en) 2015-04-29 2019-10-01 Covidien Lp Cutting ring assembly with rigid cutting member
US9987001B2 (en) 2015-06-12 2018-06-05 Covidien Lp Surgical anastomosis apparatus
US9974536B2 (en) 2015-07-02 2018-05-22 Covidien Lp Anvil assemblies and delivery systems
US10111668B2 (en) 2015-07-02 2018-10-30 Covidien Lp Anvil assembly with snap backup ring
US10117655B2 (en) 2015-07-22 2018-11-06 Covidien Lp Loading unit locking band for surgical stapling instrument
US10085756B2 (en) 2015-07-24 2018-10-02 Covidien Lp Anvil assembly and anvil assembly delivery system
US10117675B2 (en) 2015-07-28 2018-11-06 Covidien Lp Trocar tip protector
US9980730B2 (en) 2015-09-21 2018-05-29 Covidien Lp Loading unit locking collar with rotational actuated release
US10111684B2 (en) 2015-09-25 2018-10-30 Covidien Lp Adapter assembly including a removable trocar assembly
US10542992B2 (en) 2015-10-19 2020-01-28 Covidien Lp Loading unit with stretchable bushing
CN108348256B (en) 2015-10-20 2020-08-28 柯惠有限合伙公司 Circular stapler with tissue gap indicator assembly
CN108135616B (en) 2015-10-21 2022-04-15 柯惠有限合伙公司 Annular knife for surgical stapler
US10512466B2 (en) * 2015-11-05 2019-12-24 Covidien Lp Adapter assembly for surgical device
CN108289683B (en) 2015-11-13 2021-06-25 柯惠有限合伙公司 Circular stapler with audible indicator mechanism
EP3386401B1 (en) 2015-12-07 2020-08-26 Covidien LP Anvil assembly and delivery system
US10390835B2 (en) 2015-12-10 2019-08-27 Covidien Lp Surgical fastener apparatus with linear position sensor
US10524797B2 (en) 2016-01-13 2020-01-07 Covidien Lp Adapter assembly including a removable trocar assembly
US10874399B2 (en) 2016-02-04 2020-12-29 Covidien Lp Circular stapler with visual indicator mechanism
US10398439B2 (en) 2016-02-10 2019-09-03 Covidien Lp Adapter, extension, and connector assemblies for surgical devices
US10603042B2 (en) 2016-02-10 2020-03-31 Covidien Lp Flexible circular stapler
CN108697477B (en) 2016-03-04 2021-07-06 柯惠Lp公司 Robotic surgical assembly
US10595871B2 (en) 2016-05-10 2020-03-24 Covidien Lp Insertion instrument, adapter assemblies and protector assemblies for a flexible circular stapler
US11141162B2 (en) 2016-07-08 2021-10-12 Covidien Lp Loading unit locking collar with linearly actuated release
US11452522B2 (en) 2016-08-15 2022-09-27 Covidien Lp Circular stapling device with articulating anvil retainer assembly
US10426470B2 (en) 2016-11-04 2019-10-01 Covidien Lp Stapling device with releasable knife carrier
US10499922B2 (en) 2016-11-04 2019-12-10 Covidien Lp Stapling device with self-releasing knife carrier pusher
WO2018096625A1 (en) * 2016-11-24 2018-05-31 オリンパス株式会社 Medical manipulator
CN110087526B (en) 2016-12-30 2022-01-14 波士顿科学国际有限公司 System for minimally invasive treatment inside body cavity
US11241232B2 (en) 2017-01-24 2022-02-08 Covidien Lp Surgical stapling device with resettable anvil assembly
EP3573543A4 (en) 2017-01-25 2021-03-03 Covidien LP Circular stapling device and method of use
US10542993B2 (en) 2017-02-24 2020-01-28 Covidien Lp Anvil assembly of circular stapling device including alignment splines
AU2017403146A1 (en) 2017-03-09 2019-08-01 Covidien Lp Surgical stapling device with audible indicator mechanism
WO2018161301A1 (en) 2017-03-09 2018-09-13 Covidien Lp End effector assembly for circular stapler apparatus
US11241560B2 (en) 2017-03-18 2022-02-08 Boston Scientific Scimed, Inc. System for a minimally-invasive treatment within a body lumen
CN110461253B (en) 2017-03-23 2023-03-10 柯惠有限合伙公司 Circular suturing device with aligned splines
US10342534B2 (en) 2017-03-23 2019-07-09 Covidien Lp Surgical stapling device with releasable knife carrier
US10881409B2 (en) 2017-05-02 2021-01-05 Covidien Lp Rotation assembly for a surgical device
US11045199B2 (en) 2017-06-09 2021-06-29 Covidien Lp Handheld electromechanical surgical system
US10932784B2 (en) 2017-06-09 2021-03-02 Covidien Lp Handheld electromechanical surgical system
US11596400B2 (en) 2017-06-09 2023-03-07 Covidien Lp Handheld electromechanical surgical system
US10987107B2 (en) 2017-07-05 2021-04-27 Covidien Lp Surgical stapling device
US11090054B2 (en) 2017-08-07 2021-08-17 Covidien Lp Stapling device with resettable tilt anvil assembly
US10828026B2 (en) 2017-08-08 2020-11-10 Covidien Lp Tiltable anvil assembly
US10695069B2 (en) 2017-08-23 2020-06-30 Covidien Lp Circular stapling device with offset spline tip
CN111107796B (en) 2017-09-01 2023-06-30 柯惠有限合伙公司 Circular suturing device with positioning ribs
US11324507B2 (en) 2017-11-03 2022-05-10 Covidien Lp Device and method for attachment of a stomal sleeve
US11497501B2 (en) 2018-03-26 2022-11-15 Covidien Lp Circular stapling device with A-frame splines
US11000286B2 (en) 2018-03-28 2021-05-11 Covidien Lp Surgical anvil assemblies for surgical stapling instruments
US10952734B2 (en) 2018-04-23 2021-03-23 Covidien Lp Stapling device with cut ring biasing member
US11197676B2 (en) 2018-06-28 2021-12-14 Covidien Lp Tie-down method for anvil assembly delivery system
US11241234B2 (en) 2018-08-14 2022-02-08 Covidien Lp Anvil assembly with self-retaining backup member
CN112584780A (en) 2018-08-24 2021-03-30 柯惠有限合伙公司 Electric circular nailing device
US10973544B2 (en) 2018-10-02 2021-04-13 Covidien Lp Retaining mechanism for trocar assembly
US11141163B2 (en) 2018-10-04 2021-10-12 Covidien Lp Circular stapling device with anvil rotation locking structure
US11065005B2 (en) 2018-11-07 2021-07-20 Covidien Lp Reload assembly for a circular stapling device
US11147561B2 (en) 2018-11-28 2021-10-19 Covidien Lp Reload assembly for a circular stapling device
US11389263B2 (en) 2018-12-13 2022-07-19 Covidien Lp Lockout mechanisms for surgical instruments
US11166728B2 (en) 2019-02-08 2021-11-09 Covidien Lp Reload assembly for a circular stapling device
US11529144B2 (en) 2019-02-22 2022-12-20 Covidien Lp Encapsulated plug assembly for electromechanical surgical devices
US11547411B2 (en) 2019-02-22 2023-01-10 Covidien Lp Anastomosis wound protector
US11331782B2 (en) 2019-03-01 2022-05-17 Covidien Lp Reload assembly for a circular stapling device
US11337701B2 (en) 2019-03-01 2022-05-24 Covidien Lp Devices and methods for assembling adapter assemblies
US11457921B2 (en) 2019-03-26 2022-10-04 Covidien Lp Anvil assembly for surgical stapling instrument
US11596410B2 (en) 2019-04-05 2023-03-07 Covidien Lp Surgical stapling device
US11534164B2 (en) 2019-04-05 2022-12-27 Covidien Lp Strain gauge stabilization in a surgical device
US11317945B2 (en) 2019-04-16 2022-05-03 Covidien Lp Trocar assemblies for adapter assemblies for surgical stapling instruments
US11419631B2 (en) 2019-04-16 2022-08-23 Covidien Lp Trocar assemblies for adapter assemblies for surgical stapling instruments
US11660116B2 (en) 2019-04-16 2023-05-30 Covidien Lp Trocar assemblies for adapter assemblies for surgical stapling instruments
US11344330B2 (en) 2019-04-16 2022-05-31 Covidien Lp Trocar assemblies for adapter assemblies for surgical stapling instruments
US11839378B2 (en) 2019-04-19 2023-12-12 Covidien Lp Circular stapling instruments
US11399838B2 (en) 2019-04-22 2022-08-02 Covidien Lp Reload assembly for circular stapling devices
US11246599B2 (en) 2019-04-25 2022-02-15 Covidien Lp End effector for circular stapling instrument
US11896233B2 (en) 2019-05-31 2024-02-13 Covidien Lp Circular stapling device
US11690624B2 (en) 2019-06-21 2023-07-04 Covidien Lp Reload assembly injection molded strain gauge
US11446035B2 (en) 2019-06-24 2022-09-20 Covidien Lp Retaining mechanisms for trocar assemblies
US11123101B2 (en) 2019-07-05 2021-09-21 Covidien Lp Retaining mechanisms for trocar assemblies
US11357509B2 (en) 2019-07-11 2022-06-14 Covidien Lp Reload assembly for a circular stapling device
US11192227B2 (en) 2019-07-16 2021-12-07 Covidien Lp Reload assembly for circular stapling devices
US11253255B2 (en) 2019-07-26 2022-02-22 Covidien Lp Knife lockout wedge
US11464510B2 (en) 2019-07-26 2022-10-11 Covidien Lp Reload assembly with knife carrier lockout
US11399825B2 (en) 2019-10-28 2022-08-02 Covidien Lp Reload assembly with knife carrier lockout
WO2021118958A1 (en) 2019-12-13 2021-06-17 Boston Scientific Scimed, Inc. Devices, systems, and methods for minimally invasive surgery in a body lumen
US11553918B2 (en) 2019-12-16 2023-01-17 Covidien Lp Reload assembly with knife carrier lockout
US11517317B2 (en) 2020-01-06 2022-12-06 Covidien Lp Trocar release assemblies for a surgical stapler
US11730481B2 (en) 2020-01-06 2023-08-22 Covidien Lp Assemblies for retaining a trocar assembly
US11911038B2 (en) 2020-01-13 2024-02-27 Covidien Lp Cut optimization for excessive tissue conditions
US11523828B2 (en) 2020-01-28 2022-12-13 Covidien Lp Sealed reload assembly for stapling device
US11622767B2 (en) 2020-02-19 2023-04-11 Covidien Lp Sealed trocar assembly for stapling device
US11547438B2 (en) 2020-02-24 2023-01-10 Covidien Lp Tip protector for ensuring trocar insertion
US11382630B2 (en) 2020-02-25 2022-07-12 Covidien Lp Surgical stapling device with two part knife assembly
US11779343B2 (en) 2020-02-26 2023-10-10 Covidien Lp Staple reload assembly with releasable knife
US11298152B2 (en) 2020-02-28 2022-04-12 Covidien Lp Trocar retaining mechanism including band support
US11272998B2 (en) 2020-03-04 2022-03-15 Covidien Lp Strain gage fixation in tension
US11426169B2 (en) 2020-03-24 2022-08-30 Covidien Lp Retaining mechanisms for trocar assemblies
US11350939B2 (en) 2020-03-24 2022-06-07 Covidien Lp Retaining mechanisms for trocar assemblies
US11426170B2 (en) 2020-03-24 2022-08-30 Covidien Lp Retaining mechanisms for trocar assemblies
US11653925B2 (en) 2020-05-21 2023-05-23 Covidien Lp Tissue relaxation monitoring for optimized tissue stapling
US11547405B2 (en) 2020-05-22 2023-01-10 Covidien Lp Surgical stapling device
US11553921B2 (en) 2020-07-15 2023-01-17 Covidien Lp Surgical stapling device with flexible shaft
US11547412B2 (en) 2020-07-22 2023-01-10 Covidien Lp Surgical instruments and methods of assembly
US11877744B2 (en) 2020-08-14 2024-01-23 Covidien Lp Low-cost powered stapler with end stop selection
US11627966B2 (en) 2020-08-26 2023-04-18 Covidien Lp Surgical stapling device
US11801054B2 (en) 2020-09-22 2023-10-31 Covidien Lp Surgical stapler with oval tool assembly
US11712509B2 (en) 2020-10-02 2023-08-01 Covidien Lp Seal assembly for circular stapling instrument
US11627967B2 (en) 2020-11-23 2023-04-18 Covidien Lp Trans-anastomotic insertion device
US11877750B2 (en) 2021-01-21 2024-01-23 Covidien Lp Surgical stapler with powered and manual functions
US11986187B2 (en) 2021-01-29 2024-05-21 Covidien Lp Circular stapling device with integrated visualization device
US11786241B2 (en) 2021-02-16 2023-10-17 Covidien Lp Surgical stapling device including a hydraulic staple formation mechanism
US11553920B2 (en) 2021-05-03 2023-01-17 Covidien Lp Trocar retainer assembly for surgical stapler
US11490894B1 (en) 2021-05-12 2022-11-08 Covidien Lp Surgical device with grease filter
US11642131B2 (en) 2021-05-17 2023-05-09 Covidien Lp Devices and methods for shortening a rectal stump during a lower anterior resection procedure
US11612400B2 (en) 2021-05-24 2023-03-28 Covidien Lp Trocar assembly with bearing assembly for load sharing
US11744592B2 (en) 2021-08-05 2023-09-05 Covidien Lp Handheld electromechanical stapler with tissue thickness detection
US11737759B2 (en) 2021-08-05 2023-08-29 Covidien Lp Surgical stapling device accommodating prolapsed tissue
US11819208B2 (en) 2021-08-05 2023-11-21 Covidien Lp Handheld electromechanical surgical device with strain gauge drift detection
US11883028B2 (en) 2021-09-08 2024-01-30 Covidien Lp Systems and methods for post-operative anastomotic leak detection
US11717299B2 (en) 2021-10-12 2023-08-08 Covidien Lp Surgical stapling device with probiotics

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4576167A (en) * 1981-09-03 1986-03-18 United States Surgical Corporation Surgical stapler apparatus with curved shaft
US4488523A (en) * 1982-09-24 1984-12-18 United States Surgical Corporation Flexible, hydraulically actuated device for applying surgical fasteners
US4671445A (en) * 1984-08-09 1987-06-09 Baxter Travenol Laboratories, Inc. Flexible surgical stapler assembly
US4893622A (en) * 1986-10-17 1990-01-16 United States Surgical Corporation Method of stapling tubular body organs
GR920100358A (en) * 1991-08-23 1993-06-07 Ethicon Inc Surgical anastomosis stapling instrument.
US5197649A (en) * 1991-10-29 1993-03-30 The Trustees Of Columbia University In The City Of New York Gastrointestinal endoscoptic stapler
US5383880A (en) * 1992-01-17 1995-01-24 Ethicon, Inc. Endoscopic surgical system with sensing means
US5271543A (en) * 1992-02-07 1993-12-21 Ethicon, Inc. Surgical anastomosis stapling instrument with flexible support shaft and anvil adjusting mechanism
US5507773A (en) * 1994-02-18 1996-04-16 Ethicon Endo-Surgery Cable-actuated jaw assembly for surgical instruments
US5868760A (en) * 1994-12-07 1999-02-09 Mcguckin, Jr.; James F. Method and apparatus for endolumenally resectioning tissue
US6119913A (en) * 1996-06-14 2000-09-19 Boston Scientific Corporation Endoscopic stapler
US5960776A (en) * 1996-11-21 1999-10-05 Siemens Canada Limited Exhaust gas recirculation valve having a centered solenoid assembly and floating valve mechanism
US6601749B2 (en) * 1998-06-19 2003-08-05 Scimed Life Systems, Inc. Multi fire full thickness resectioning device
US6126058A (en) * 1998-06-19 2000-10-03 Scimed Life Systems, Inc. Method and device for full thickness resectioning of an organ
US6517565B1 (en) * 1999-06-02 2003-02-11 Power Medical Interventions, Inc. Carriage assembly for controlling a steering wire steering mechanism within a flexible shaft
DE19951940C2 (en) * 1999-10-28 2001-11-29 Karlsruhe Forschzent Clamping device that can be used endoscopically
US6685079B2 (en) * 2002-05-24 2004-02-03 Scimed Life Systems, Inc. Full thickness resectioning device

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CA2454160C (en) 2010-04-13
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US6685079B2 (en) 2004-02-03
US20040118896A1 (en) 2004-06-24
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US6938814B2 (en) 2005-09-06
US20030218047A1 (en) 2003-11-27
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US20050263561A1 (en) 2005-12-01
WO2003099138A2 (en) 2003-12-04
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US7559451B2 (en) 2009-07-14
AU2003234288B2 (en) 2008-12-18
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