JP4356180B2 - Automatic synthesizer - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an automatic synthesizer that automatically generates a synthetic compound, and more particularly to a technique for setting a synthesis procedure (synthesis protocol) for performing a synthesis reaction.
[0002]
[Prior art]
A conventional automatic synthesizer used in research fields such as pharmaceuticals, life sciences, chemistry, and materials has a reaction block in which a large number of reaction vessels for performing a synthesis reaction are arranged, and is a preset synthesis procedure. Based on the synthesis protocol, each reaction vessel is dispensed with a reaction solution such as a reagent and a solvent, and the reaction block is heated and vibrated, for example, to promote the synthesis reaction in each reaction vessel. It is comprised so that a synthetic compound may be produced | generated in.
[0003]
To set the synthesis protocol, first, the operator displays a synthesis protocol creation screen on the monitor. Set the synthesis protocol directly by hand on the displayed synthesis protocol screen. Alternatively, the synthesis protocol set in the past is read and the part to be changed is directly set manually, or copied from another part and pasted on the changed part.
[0004]
[Problems to be solved by the invention]
However, the conventional example having such a configuration has the following problems.
In other words, the synthesis protocol includes various procedures such as procedures for dispensing reagents and solvents, procedures for heating and vibrating reaction blocks, etc., so it is set manually or copied and pasted. Setting a conventional synthesis protocol takes time. Therefore, it is a heavy burden on the operator, and the work efficiency up to the setting of the synthesis protocol is deteriorated. Moreover, the setting of the synthesis protocol including various procedures also causes an operator input setting error.
[0005]
This invention is made | formed in view of such a situation, Comprising: It aims at providing the automatic synthesizer which can set the synthetic | combination protocol for performing a synthetic reaction easily.
[0006]
[Means for Solving the Problems]
In order to achieve such an object, the present invention has the following configuration.
That is, the invention according to claim 1 is a reaction block in which a plurality of reaction vessels for performing a synthesis reaction are arranged, a dispensing means for dispensing a reaction solution into each reaction vessel of the reaction block, and the reaction A synthesis protocol storage means for storing a synthesis protocol for performing a synthesis reaction in a container, and based on the synthesis protocol, dispensing a plurality of types of reaction liquids in the reaction container, In an automatic synthesizer for generating a synthetic compound in the reaction vessel, (a) protocol display means for displaying a synthesis protocol read from the synthesis protocol storage means, and (b) synthesis displayed by the protocol display means A range setting means for setting a protocol range; and (c) a command for determining individual composition commands in the composition protocol based on the range setting means. Determining means; (d) parameter setting means for reading out and displaying the parameters of the composite command determined by the command determining means and changing the parameters of the composite command to set parameters; and (e) the parameter setting. Synthesis protocol changing means for changing the synthesis protocol based on the parameters of the synthesis command changed by the means The synthesis protocol changing unit collectively changes the synthesis protocol within the range set by the range setting unit, and at that time, the synthesis protocol in a portion other than the range is not changed. It is characterized by that.
[0007]
[Action]
The operation of the first aspect of the invention will be described.
According to the automatic synthesis apparatus of the present invention, the protocol display means displays the synthesis protocol based on the synthesis protocol stored in the synthesis protocol storage means. The range setting means sets the range of the synthesis protocol displayed by the protocol display means. The command determining means determines a composite command based on the range set by the range setting means for each procedure constituting the composite protocol, that is, the composite command. The parameter setting means displays the parameter that determines the element of the composite command and newly sets the parameter. The composition protocol changing means changes the displayed original composition protocol based on the parameter for which the setting has been changed. Thereby, the parameter determined by the command determination unit and the parameter setting unit is changed only for the synthesis protocol in the range set by the range setting unit.
[0008]
DETAILED DESCRIPTION OF THE INVENTION
An embodiment of the present invention will be described below with reference to the drawings.
FIG. 1 is a block diagram showing an overall configuration of an automatic organic synthesizer according to an embodiment of the present invention. FIG. 2 is a plan view showing the configuration of the reaction system of the example apparatus. FIG. 3 is a schematic diagram showing the main configuration of the reaction block of the example apparatus.
[0009]
As shown in FIG. 1, the automatic synthesizer of the embodiment includes a reaction system in which a synthesis reaction is actually performed and a control system that controls the movement of the reaction system. Hereinafter, the structure of the reaction system of the example apparatus will be described first.
[0010]
The apparatus of the embodiment includes a reaction block 1 in which a plurality of reaction vessels 2 for performing a synthesis reaction are arranged, and a plurality of types of reaction liquids such as reagents and solvents in a reaction vessel (reaction vessel) 2 according to a predetermined procedure. A liquid dispensing unit 3 for dispensing is provided. As shown in FIG. 2, each reaction vessel 2 is installed in the reaction block 1 in an arrangement of a vertical and horizontal matrix. The number of reaction containers 2 installed in the reaction block 1 is not limited to a specific number, and for example, the number of containers of several tens to several hundreds such as 96 or 384 is exemplified. In the case of the embodiment apparatus, the reagent and the solvent are dispensed and supplied to the reaction vessel 2 by a common dispensing mechanism, but the reagent and the solvent are dispensed and supplied by separate dispensing mechanisms. There may be.
[0011]
The liquid dispensing unit 3 includes a syringe 4 and a syringe moving mechanism unit 5 that moves the syringe 4 left and right (X), front and rear (Y), and top and bottom (Z), and moves the syringe according to a command signal from the control system side. The mechanism unit 5 is actuated so that the syringe 4 is moved to a necessary position.
[0012]
On the other hand, by the side of the reaction block 1, a large frequent reagent container (frequent reagent vial) 6 in which a relatively large amount of chemical solution is stored and a small amount in which a relatively small amount of chemical solution is stored. The common reagent containers (common reagent vials) 7 are provided with a place for setting the required number of each. In addition, a place for setting the required number of solvent containers (gallon bins) 8 in which a solvent is stored is provided beside the reaction block 1, and each of the set solvent containers 8 is connected by a liquid feeding line 9. The syringe 4 is configured to be connectable. The operator sets the frequent reagent container 6, the regular reagent container 7, and the solvent container 8 to the apparatus. The reagents and solvents stored in these containers 6, 7, and 8 correspond to the reaction liquid in the present invention.
[0013]
When the chemical solution is dispensed and supplied to the reaction container 2, the syringe 4 is moved to the position of the frequent reagent container 6 or the regular reagent container 7 in which the chemical solution to be dispensed is stored, as shown by the dotted line in FIG. After the reagent is sucked from the syringe needle 4a, the reagent in the syringe 4 is moved to the position of the reaction container 2 to be dispensed, and then the sucked reagent is injected from the syringe needle 4a into the reaction container 2.
[0014]
When the solvent is dispensed and supplied to the reaction container 2, the solvent is introduced into the syringe 4 from the solvent container 8 in which the solvent to be dispensed is stored via the liquid feeding line 9, and the syringe 4 is reacted to the solvent dispensing target. The solvent is moved to the position of the container 2 and the introduced solvent is injected into the reaction container 2 from the syringe needle 4a. Normally, as described above, the liquid is aspirated at the position of the frequent reagent container 6 or the common reagent container 7, and the syringe 4 is moved so as to inject the liquid at the position of the reaction container 2. In the case of the apparatus, conversely, the liquid can be sucked at the position of the reaction container 2 and the syringe 4 can be moved so as to inject the liquid at the position of the frequent reagent container 6 or the common reagent container 7. Yes.
[0015]
In the case of the reaction block 1 of the example apparatus, as shown in FIG. 3, the sheet-like common septum 10 that covers the injection port of each reaction vessel 2 and each reaction vessel 2 so as to close the bottom side inside of the reaction vessel 2. A pressure permeable filter 11 attached to each reaction vessel and a drain 12 connected to each reaction vessel 2 so as to communicate with the bottom of the reaction vessel 2 are provided, and a gas cylinder is provided on the inlet side of the reaction vessel 2. A gas introduction line 13 for introducing pressurized gas (for example, high-pressure inert gas) from GB is provided. Therefore, the syringe needle 4a penetrates through the common septum 10 and enters the reaction container 2 at the time of reagent injection or solvent injection. In addition, each reaction vessel 2 is provided with an appropriate amount of resin particles 14 for solid-phase reaction, and an open / close valve 15 is provided at the end of the gas introduction line 13. When the pressurized gas is introduced into the valve, the on-off valve 15 is closed.
[0016]
In addition, the example apparatus is provided with a vibration unit 16 that vibrates the reaction block 1 during the synthesis reaction and shakes the resin particles 14 in each reaction vessel 2, and in each reaction vessel 2 during the reaction process. A discharge tray 17 for discharging generated unnecessary materials, and a recovery block 18 for recovering the synthetic compound obtained in each reaction vessel 2 by the synthesis reaction for each reaction vessel 2 are also located below the reaction block 1 respectively. It is arranged to be movable between standby positions.
[0017]
In the synthesis process in the automatic synthesizer of the example, a solid phase reaction proceeds in the resin particles 14 of each reaction vessel 2 to which necessary reagents and solvents are dispensed and supplied, and the target synthetic compound is obtained. After completion of the synthesis reaction, an extraction (acidic) chemical solution for taking out the compound produced in the resin particles 14 is fed from the injection port. When the compound is extracted, the pressurized gas of the gas cylinder GB is introduced from the gas introduction line 13, and the synthetic compound is allowed to pass through the pressurized liquid-permeable filter 11 together with the extraction chemical solution and is pushed from the drain 12 to the recovery block 18. .
[0018]
Next, the configuration of the control system of the embodiment apparatus will be described. In the case of the automatic synthesizing apparatus of the embodiment, a video display monitor 19 that displays various screens necessary for the operation of the apparatus and a control unit 20 that executes various controls necessary for the operation of the apparatus in a timely manner are provided. In addition to having input operation devices such as a keyboard (operating console) 21 and a mouse (pointing device) 22 connected, for example, a composite protocol range for storing (reading) and reading a composite protocol to be described later is set. It has a characteristic configuration for setting parameters, changing a synthesis protocol, and the like. Hereinafter, this characteristic configuration will be specifically described.
[0019]
The control unit 20 of the embodiment apparatus has a screen display unit 23 that displays a screen necessary for the operation of the apparatus on the video display monitor 19 and a synthesis that stores a synthesis protocol that is input and set in advance by an input operation device such as the keyboard 21 and the mouse 22. A protocol storage unit 24, and a dispensing control unit 25 for sending a command signal for executing a dispensing operation according to a dispensing procedure in the synthesis protocol stored in the synthesis protocol storage unit 24 to the liquid dispensing unit 3. A range setting unit 26 that sets the range of the synthesis protocol displayed by the screen display unit 23 based on an input operation; a command determination unit 27 that determines individual synthesis commands in the synthesis protocol based on the range setting unit 26; The parameters of the composite command determined by the command determination unit 27 are read and displayed, and the parameters of the composite command are displayed. A parameter setting unit 28 for setting parameters by changing the data based on the input operation, and a synthesis protocol changing unit 29 for changing the synthesis protocol based on the parameters of the synthesis command changed by the parameter setting unit 28. ing.
[0020]
The screen display unit 23 appropriately displays various screens such as a composite protocol setting screen for an operator to set a composite protocol and a wizard-type screen such as a parameter change setting screen for changing and setting parameters. The synthetic protocol setting screen displayed on the screen display unit 23 corresponds to the protocol display means in the present invention.
[0021]
The synthesis protocol storage unit 24 stores the synthesis protocol set using the keyboard 21 and the mouse 22 in accordance with the synthesis protocol setting screen displayed on the video display monitor 19. In this synthesis protocol, steps to be performed when performing a plurality of types of synthesis reactions, an execution order of each step, a detailed procedure of each step, and the like are set. For example, these processes include a dispensing process for dispensing a predetermined chemical solution into a predetermined reaction container 2, a stirring process for shaking the reaction block 1 to stir the reaction container 2, the reaction container 2 and the syringe 4 and the like. A draining process for draining the solution of the solution, a purging process for purging the solution in the syringe 4, a container washing process for washing each container, a standby process for waiting for the apparatus, a temperature adjusting process for raising or lowering the temperature of the reaction block 1, etc. There is a process. For example, in a certain stirring process, a procedure is set such that the electric motor is rotated at 900 rpm and the reaction block 1 is swung for one hour. Similarly, the control procedure of the apparatus according to the process is set also in each other process. In this way, a synthesis protocol is configured by setting parameters necessary for each of these steps. The synthesis protocol storage unit 24 corresponds to the synthesis protocol storage unit in the present invention.
[0022]
Note that the synthesis protocol stored in the synthesis protocol storage unit 24 is read by the keyboard 21 and the mouse 22 and further displayed on the synthesis protocol setting screen of the video display monitor 19 by the screen display unit 23. For example, as shown in FIG. 4, by clicking the “Open” icon on the toolbar 19a of the synthesis protocol setting screen 19A, the synthesis protocol stored in the synthesis protocol storage unit 24 (specifically, the file name of the synthesis protocol). And a directory in which the synthesis protocol is stored) is designated, the designated synthesis protocol is read from the synthesis protocol storage unit 24 and displayed as the synthesis protocol 19b. In addition to the method of using the toolbar 19a described above, the file can be opened by clicking on the “file” in the menu bar 19c with the mouse 22 or by using a shortcut key (eg, “Ctrl” key and “ The method is not particularly limited as long as it is a method of opening a file from the screen by a generally well-known means, such as a method of typing and opening the “O” key at the same time).
[0023]
As shown in FIG. 4, the read synthesis protocol 19b has row numbers assigned to the left section Lb in the order of the composition protocol in the vertical direction, and instructions for executing each procedure, that is, synthesis commands, are assigned to the right section Rb. Are displayed vertically corresponding to the row numbers. For example, the execution command “250 μL of solvent used = solvent 3 (syringe 3)” from the dispensing frequent reagent rack / 3A to the reaction rack 5A is displayed on the right side of “line number 37”. Here, the “common reagent rack” indicates the frequent reagent container (common reagent vial) 6, the “reaction rack” indicates the reaction container 2, and the “used solvent” indicates the used solvent in the solvent container (gallon bottle) 8. The above “syringe” indicates the syringe 4 for the solvent used for inhaling and injecting the solvent used. Further, in this embodiment, the frequent reagent is constituted by a block composed of six frequent reagent containers (frequent reagent vials) 6 (not shown), and (1, 2, 3) rows in the row direction and column directions. (A, B) columns are arranged. The “frequent reagent rack 3 / A” indicates a container in 3 rows and A columns among the six blocks of the frequent reagent container (frequent reagent vial) 6. Similarly, in this embodiment, the reaction vessel (reaction rack) is constituted by a block of 96 reaction vessels 2 (not shown), and (1, 2,..., 11, 12) rows in the row direction. , (A, B, C, D, E, F, G, H) are arranged in columns. The “reaction rack 5A” indicates a container in 5 rows and A columns among the 96 blocks of the reaction container 2. Similarly, in this embodiment, there are a total of four solvent containers (gallon bins) 8, and the “solvent 3” indicates the third solvent container (gallon bin) 8. There are four syringes 4 in total, and the above “syringe 3” indicates the third syringe 4. Therefore, the above execution command of “Row No. 37” is the third solvent used for the 250 μL of the frequent reagent from the frequent reagent container (common reagent vial) 6 in the third row A column to the reaction container 2 in the fifth row A column. A dispensing process is shown in which injection is performed using the working solvent in the syringe 4 and the third solvent container (gallon bottle) 8.
[0024]
The dispensing control unit 25 transmits a command signal corresponding to the dispensing process included in the synthesis protocol to the liquid dispensing unit 3. In addition, command signals corresponding to other steps included in the synthesis protocol are also sent to corresponding mechanisms on the reaction system side. And the synthetic compound according to each condition is each produced | generated by each reaction container 2 by performing each process included in a synthetic protocol.
[0025]
The range setting unit 26 sets the range of the composition protocol 19b displayed on the composition protocol setting screen 19A of the video display monitor 19 by the screen display unit 23 based on the input setting using the keyboard 21 and the mouse 22. . For example, when the range of the composition protocol 19b to be changed is from “line number 36” to “line number 59”, the operator clicks the start point “line number 36” with the mouse 22 and then drags to the end point “line number 59”. Perform the operation. The method of setting the range is not limited to the method of performing a drag operation with the mouse 22, and after clicking the start point “line number 36” with the mouse 22, the end point is reached with the mouse 22 while pressing the “Shift” key on the keyboard 21. The method is not particularly limited as long as it is a method of setting a range from the screen by a generally well-known means such as a method of clicking “line number 59”. Of course, as described above, not only a range in which a range to be changed is continuous, but also a plurality of non-continuous portions can be set as a range to be changed. For example, when the range of the synthesis protocol 19b to be changed is from “line number 36” to “line number 38” and from “line number 60” to “line number 62”, the start point “line number 36” is clicked with the mouse 22 After that, drag to the end point “line number 38”, click the start point “line number 60” with the mouse 22 while holding down the “Ctrl” key on the keyboard 21, and then drag to the end point “line number 62”. By doing so, it is possible to set a plurality of non-consecutive portions. Note that the range of the composition protocol 19b set by the range setting unit 26 is reversed with respect to the screen color as a range 19d as shown in FIG. In addition, since the range 19d of the synthesis protocol to be changed is determined by the range setting unit 26, the range to be changed and the range not to be changed can be instantaneously distinguished. This range setting unit 26 corresponds to the range setting means in the present invention.
[0026]
The command determination unit 27 reads the range of the synthesis protocol determined by the range setting unit 26 and determines a synthesis command corresponding to the range. For example, as shown in FIG. 5, a range 19d from “line number 36” to “line number 59” set by the range setting unit 26 is a process related to the dispensing process. Accordingly, the command determination unit 27 determines “injection”, “injection amount”, “use solvent”, and the like of the injection destination of the reaction vessel 2 which are the respective commands constituting the dispensing process in the range 19d. When the range 19d is clicked with the right button of the mouse 22, the above-mentioned commands “injection”, “injection amount” and “solvent used” determined by the command determination unit 27 are superimposed and displayed as a pull-down menu 19e. In addition, “time” and “rotation speed” for stirring in the stirring process, “time” for draining in the draining process, designated “compartment” and “valve” for the reaction vessel 2 for draining, It is determined by the command determination unit 27 and is similarly displayed as a pull-down menu 19e when the right button of the mouse 22 is clicked. Note that the method of displaying the determined command is not limited to the method of clicking with the right button of the mouse 22, but the method of displaying the command by clicking "edit" on the menu bar 19c in FIG. The method is not particularly limited as long as it is a method of displaying from the screen by means that are usually well known. The command determination unit 27 corresponds to command determination means in the present invention.
[0027]
The parameter setting unit 28 reads out the parameters of the composite command determined by the command determination unit 27 and displays them on the parameter change setting screen of the video display monitor 19, and further, based on the input settings using the keyboard 21 and the mouse 22. Change the parameters of the compositing command and set the parameters. For example, as shown in FIG. 5, when the “injection amount” of the pull-down menu 19e displayed in a superimposed manner is selected by dragging with the right button of the mouse 22, the parameter for determining the element of the injection amount, ie, the injection amount “250 μL” is selected. Is read out. At this time, the color of the range 19d is further inverted to return to the same color as the screen color. The read parameters are superimposed and displayed as a parameter change setting screen 19f as shown in FIG. Further, the current injection amount “250 μL” before the change is displayed in the “present” stage of the parameter change setting screen 19f. Further, “change” is displayed in the lower part of the “current”, and the parameter value to be changed can be manually input by the keyboard 21 or the like. For example, when it is desired to change the current injection amount from “250 μL” to “230 μL”, the parameter can be set by manually inputting “230” in the “change” stage. It is changed from “250 μL” to “230 μL” manually by the “OK” button in the lower part of the parameter change setting screen 19 f. If it is not changed, it can be canceled by the “cancel” button at the lower stage of the parameter change setting screen 19f even after the manual input operation. Of course, if a command other than “injection amount” is selected, the parameter displayed on the parameter change setting screen 19 f changes according to the selected parameter. The method of setting the parameters is not limited to the method of clicking with the right button of the mouse 22, but as described above, the command is displayed by clicking “Edit” on the menu bar 19c of FIG. 4 with the mouse 22. The method is not particularly limited as long as it is a method of setting from the screen by a generally well-known means, such as a method of clicking a composite command such as “injection amount” and setting parameters of the composite command. By this parameter setting unit 28, the parameter of the synthesis command before the change can be instantaneously distinguished from the parameter to be changed and set. The parameter setting unit 28 corresponds to parameter setting means in the present invention.
[0028]
The synthesis protocol changing unit 29 changes the original synthesis protocol based on the parameters of the synthesis command changed by the parameter setting unit 28. For example, when the “injection amount” is changed from “250 μL” to “230 μL” as described above, the range 19d in FIG. 5 is simultaneously converted into the range 19D as shown in FIG. That is, the injection amount “250 μL” is collectively replaced with “230 μL”. Of course, portions other than the range 19d set by the range setting unit 26 remain unchanged. The synthesis protocol changing unit 29 corresponds to the synthesis protocol changing means in the present invention.
[0029]
The configuration of the control system of the above-described embodiment apparatus is built around a personal computer and software (computer program). The synthesis protocol storage unit 24 in the control unit 20 is configured by a storage device such as a RAM or a ROM, and includes a screen display unit 23, a dispensing control unit 25, a range setting unit 26, a command determination unit 27, a parameter setting unit. 28, the processing control unit such as the synthesis protocol changing unit 29 is configured by a CPU that executes a program for performing these processes.
[0030]
Next, the processing of the characteristic part of the present invention in the embodiment apparatus having the above configuration will be described with reference to the flowchart shown in FIG.
[0031]
Step S1 (Display of synthesis protocol)
The operator operates the keyboard 21 and the mouse 22 to display a composite protocol setting screen 19A as shown in FIG. Step S1 corresponds to the function of the protocol display means in the present invention.
[0032]
Step S2 (Composition protocol range setting)
The operator uses the keyboard 21 and the mouse 22 to set the range of the synthesis protocol 19b displayed on the synthesis protocol setting screen 19A. As shown in FIG. 5, the set range of the composition protocol 19b is reversed with respect to the screen color as a range 19d. By this inversion, the range to be changed and the range not to be changed can be instantaneously distinguished. Step S2 corresponds to the function of the range setting means in the present invention.
[0033]
Step S3 (Determination of composite command)
Based on the range 19d set in step S2, each command composing the range 19d is determined. Each determined command is displayed in a superimposed manner on a screen such as a pull-down menu 19e as shown in FIG. Step S3 corresponds to the function of the command determining means in the present invention.
[0034]
Step S4 (Composition command parameter setting)
The operator selects a composite command to be changed from a screen such as a pull-down menu 19e as shown in FIG. As shown in FIG. 6, the parameter of the selected compositing command is displayed superimposed on the parameter change setting screen 19f or the like. The parameter to be changed is set manually or the like from the parameter change setting screen 19f. Further, by displaying a list of the parameters of the composite command before the change and the parameters to be changed on the parameter change setting screen 19f, the parameters of the composite command before the change and the parameters to be changed can be instantaneously distinguished. . Furthermore, even after manual input, it can be canceled with the “cancel” button on the parameter change setting screen 19f, so that it is possible to prevent operator input setting errors. Step S4 corresponds to the function of the parameter setting means in the present invention.
[0035]
Step S5 (change of synthesis protocol)
As shown in FIG. 7, the range 19d of the parameter change setting screen 19f is converted into the range 19D all at once according to the parameters of the synthesis command set in step S4, and the portions other than the selected range 19d are changed. Without any change. By completing the steps up to step S5, the setting of one composition protocol is completed. Also, by changing only the part to be changed at once, the work efficiency up to the setting of the synthesis protocol is improved. Step S5 corresponds to the function of the synthesis protocol changing means in the present invention.
[0036]
Step S6 (composition protocol setting determination)
If there are still synthesis protocols that need to be set, the process returns to step S2 to start setting the next synthesis protocol. If there is no synthesis protocol that must be set, the setting operation ends.
[0037]
The synthesis protocol set in steps S1 to S6 described above is written again in the synthesis protocol storage unit 24 in preparation for changing the synthesis protocol. Further, based on the above synthesis protocol, the example apparatus performs a synthesis reaction.
[0038]
As described in detail above, according to the automatic synthesizing device of the embodiment, the range setting unit 26 can instantaneously distinguish between a range to be changed and a range not to be changed. In addition, the parameter setting unit 28 displays a list of the parameters of the composite command before the change and the parameter to be changed on the parameter change setting screen 19f, so that the parameter of the composite command before the change and the parameter to be changed are set. The parameter can be distinguished instantaneously. Further, even after manual input, it can be canceled by the “cancel” button on the parameter change setting screen 19f, so that an operator's input setting error can be prevented in advance. In addition, since the previously created synthesis protocol can be reused and changed at once by the synthesis protocol changing unit 29, the work efficiency up to the setting of the synthesis protocol is improved.
[0039]
The present invention is not limited to the above-described embodiment, and can be modified as follows.
[0040]
(1) In the above-described embodiment, as shown in FIG. 4, the synthesis protocol set in the past is read and the setting of the synthesis protocol is changed. However, the present invention is not limited to this. It is also possible to create a new synthesis protocol by clicking the “create new” icon on the toolbar 19a of the screen 19A, and then change the setting of the synthesis protocol. Of course, a method for creating a new synthesis protocol is not limited to the method using the toolbar 19a described above, but can be created by clicking the “file” on the menu bar 19c with the mouse 22 or by using a shortcut key (for example, “ Type “Ctrl” key and “N” key at the same time), or create directly from the synthesis protocol setting screen 19A without reading other files. There is no particular limitation as long as it is a method for creating a new file.
[0041]
(2) In the automatic synthesizer of the above-described embodiment, the reaction system is one set, but a device having a configuration in which two identical reaction systems controlled by one set of control systems are provided is a modified example. As mentioned.
[0042]
(3) The example apparatus was an organic automatic synthesizer, and the compound was synthesized by solid-phase reaction. However, the apparatus of the present invention may be an inorganic automatic synthesizer or a liquid phase. An apparatus configured to synthesize a compound by reaction may be used.
[0043]
【The invention's effect】
As described above in detail, according to the automatic synthesizing apparatus according to the first aspect of the present invention, the synthesis protocol changing means can reuse the synthesis protocol created previously and can change it all at once. Work efficiency up to protocol setting is improved. The protocol display means and the range setting means display a list of synthesis protocols and the range of the synthesis protocol to be changed is determined, so that the range to be changed and the range not to be changed can be instantaneously distinguished. Further, the command determination means and the parameter setting means can instantaneously distinguish the composite command parameter before the change and the parameter to be changed and set. By these, an operator's input setting mistake can be prevented.
[Brief description of the drawings]
FIG. 1 is a block diagram illustrating an overall configuration of an automatic synthesis apparatus according to an embodiment.
FIG. 2 is a plan view showing a configuration of a reaction system of the example apparatus.
FIG. 3 is a schematic view showing a main configuration of a reaction block of the example apparatus.
FIG. 4 is a diagram illustrating a synthesis protocol setting screen of the embodiment apparatus.
FIG. 5 is a diagram illustrating a synthesis protocol setting screen from setting a range to setting parameters.
FIG. 6 is a diagram showing a parameter change setting screen.
FIG. 7 is a diagram illustrating a composition protocol setting screen after setting change.
FIG. 8 is a flowchart showing a flow from reading a synthesis protocol to changing the setting of the synthesis protocol.
[Explanation of symbols]
1 ... Reaction block
2… Reaction vessel
3 ... Liquid dispensing part
19 ... Video display monitor
21 ... Keyboard
22 ... Mouse
23 ... Screen display section
24 ... Synthesis protocol storage unit
25 ... Dispensing control unit
26 ... Range setting section
27 ... Command determination part
28 ... Parameter setting section
29 ... Synthesis protocol change part

Claims (1)

A reaction block in which a plurality of reaction vessels for performing a synthesis reaction are arranged, a dispensing means for dispensing a reaction solution into each reaction vessel of the reaction block, and a synthesis protocol for performing a synthesis reaction in the reaction vessel And a synthesis protocol storage means for storing a compound, and based on the synthesis protocol, a plurality of types of reaction liquids are dispensed into the reaction vessel to perform synthesis, thereby automatically generating a synthetic compound in the reaction vessel. In the synthesizing apparatus, (a) protocol display means for displaying the synthesis protocol read from the synthesis protocol storage means, (b) range setting means for setting the range of the synthesis protocol displayed by the protocol display means, (C) command determining means for determining individual composite commands in the composite protocol based on the range setting means; and (d) the command Parameter setting means for reading and displaying the parameters of the composite command determined by the determination means and changing the parameters of the composite command to set parameters; and (e) the parameters of the composite command changed by the parameter setting means. based on, a synthesizing protocol changing means for changing the synthetic protocol,
The synthesis protocol changing means collectively changes the synthesis protocol within the range set by the range setting means,
At that time, the synthesis protocol in the portion other than the range is not changed .

Images