JP4013406B2 - Automatic synthesizer - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to an automatic synthesizer that automatically generates a synthetic compound, and more particularly to a technique for generating an analysis schedule in an analyzer for analyzing the generated synthetic compound.
[0002]
[Prior art]
A conventional automatic synthesizer used in research fields such as pharmaceuticals, life sciences, chemistry, and materials has a reaction block in which a large number of reaction vessels for performing a synthesis reaction are arranged, and is a preset synthesis procedure. Based on the synthesis protocol, reagents and solvents are dispensed into each reaction vessel, and the reaction block is heated and vibrated, for example, to promote the synthesis reaction in each reaction vessel and synthesize in each reaction vessel. It is configured to produce a compound. Furthermore, conventionally, in the above-described research field, as an integral inseparate operation after generating a synthetic compound, in order to examine whether the synthetic compound synthesized in each reaction vessel is made as desired, for example, Each of these synthetic compounds is analyzed with an analyzer.
[0003]
In order to analyze each synthetic compound with the analyzer, the operator first inputs various input information such as the analysis conditions of the synthetic compound, the control conditions of the analyzer, the sample name of the synthetic compound, and the name of the file to save the analysis results. Is created for each synthetic compound. Then, by applying each synthetic compound to the analyzer, the analyzer operates according to the analysis schedule and analyzes each synthetic compound.
[0004]
[Problems to be solved by the invention]
However, the conventional example having such a configuration has the following problems.
In other words, referring to the contents of the synthesis protocol used in conventional automatic synthesizers, various types of input information are entered into the analyzer for each synthetic compound, so input work increases as the types of synthetic compounds increase. As a result, the series of operations from automatic synthesis to analysis becomes increasingly complicated. For this reason, there is a problem that work efficiency from automatic synthesis to analysis is poor due to factors such as an operator's input mistake and time required for input work.
[0005]
The present invention has been made in view of such circumstances, and an object thereof is to provide an automatic synthesizing apparatus capable of improving the work efficiency from automatic synthesis to analysis.
[0006]
[Means for Solving the Problems]
In order to achieve such an object, the present invention has the following configuration.
The invention according to claim 1 is a reaction block in which a plurality of reaction vessels for performing a synthesis reaction are arranged, a dispensing means for dispensing a reaction solution into each reaction vessel of the reaction block, and the inside of the reaction vessel To perform the synthesis reaction Is the synthesis procedure set to And a synthesis protocol storage means for storing a synthesis protocol. Based on the synthesis protocol, a synthetic compound is generated in the reaction vessel by dispensing a plurality of types of reaction liquids in the reaction vessel and performing synthesis. In the automatic synthesizer, the synthesis protocol used to generate the synthetic compound in the reaction vessel is analyzed, and the first input information to be input to the analyzer for analyzing the generated synthetic compound is synthesized. A synthesis protocol analysis means for extracting from the protocol; an input information storage means for storing second input information that is input to the analyzer and not included in the synthesis protocol; and extracted from the synthesis protocol Based on the first input information and the second input information read from the input information storage means , The synthetic compound For analyzing Is data for operating the analyzer An analysis schedule generating means for generating an analysis schedule is provided.
[0007]
The invention according to claim 2 is the automatic synthesizer according to claim 1, further comprising input means for inputting the second input information, wherein the input information storage means is a first input by the input means. 2 input means are stored.
[0008]
The invention according to claim 3 is the automatic synthesizer according to claim 1 or 2, further comprising instruction means for indicating any reaction vessel in the reaction block, wherein the synthesis protocol analysis means is any The first input information for analyzing the synthetic compound generated in the reaction container is taken out from the synthesis protocol, and the analysis schedule generating means includes the first input information and the second input information. Based on the above, an analysis schedule for analyzing the synthetic compound generated in any reaction vessel instructed by the instruction means is generated.
[0009]
[Action]
The operation of the present invention is as follows.
According to the first aspect of the present invention, based on the synthesis protocol stored in the synthesis protocol storage means, the reaction solution is dispensed into each reaction vessel of the reaction block by the dispensing means to produce a synthetic compound. Thereby, for example, different types of synthetic compounds are generated in each reaction vessel. The synthesis protocol analyzing means analyzes the synthesis protocol used for generating the synthetic compound in the automatic synthesizer, and inputs it to the analyzer for analyzing the synthetic compound included in the synthesis protocol. Retrieve input information for. The input information storage means stores second input information that is input information not included in the synthesis protocol. The analysis schedule generation means operates the analysis apparatus to analyze each synthetic compound based on the first input information retrieved by the synthesis protocol analysis means and the second input information read from the input information storage means. An analysis schedule, which is data to be generated, is generated. The analyzer analyzes each synthesized compound according to the analysis schedule generated by the automatic synthesizer.
[0010]
According to the invention of claim 2, the second input information which is input information to be input to the analyzer and is not included in the synthesis protocol is input by the input means. The input information storage means stores the input second input information. The analysis schedule generation means is in a data format for operating the analyzer to analyze each synthetic compound based on the first input information extracted from the synthesis protocol and the input second input information. Generate an analysis schedule.
[0011]
According to the invention of claim 3, an arbitrary reaction vessel in the reaction block is indicated by the instruction means. The synthesis protocol analysis means extracts first input information for analyzing the synthetic compound in any reaction vessel from the synthesis protocol. The analysis schedule generating means generates an analysis schedule for analyzing the synthetic compound in any reaction vessel based on the first input information and the second input information.
[0012]
DETAILED DESCRIPTION OF THE INVENTION
An embodiment of the present invention will be described below with reference to the drawings.
FIG. 1 is a block diagram showing an overall configuration of an automatic organic synthesizer according to an embodiment of the present invention. FIG. 2 is a plan view showing the configuration of the reaction system of the example apparatus. FIG. 3 is a schematic diagram showing the main configuration of the reaction block of the example apparatus.
[0013]
As shown in FIG. 1, the automatic synthesis apparatus of the embodiment includes a reaction system in which a synthesis reaction is actually performed and a control system that controls the movement of the reaction system. Hereinafter, the structure of the reaction system of the example apparatus will be described first.
[0014]
The apparatus according to the embodiment includes a reaction block 1 in which a plurality of reaction vessels 2 for performing a synthesis reaction are arranged, and a plurality of types of reaction liquids such as reagents and solvents in a reaction vessel (reaction vessel) 2 according to a predetermined procedure. A liquid dispensing unit 3 for dispensing is provided. As shown in FIG. 2, each reaction vessel 2 is installed in the reaction block 1 in an arrangement of a vertical and horizontal matrix. The number of reaction vessels 2 installed in the reaction block 1 is not limited to a specific number, and for example, tens to hundreds of vessels such as 96 pieces and 384 pieces are exemplified. In the case of the embodiment apparatus, the reagent and the solvent are dispensed and supplied to the reaction vessel 2 by a common dispensing mechanism, but the reagent and the solvent are dispensed and supplied by separate dispensing mechanisms. There may be.
[0015]
The liquid dispensing unit 3 includes a syringe moving mechanism unit 5 that moves the syringe 4 and the syringe 4 left and right (X), front and rear (Y), and top and bottom (Z), and in accordance with a command signal from the control system side, the syringe moving mechanism unit 5 is actuated so that the syringe 4 is moved to the required position.
[0016]
On the other hand, by the side of the reaction block 1, a large frequent reagent container (frequent reagent vial) 6 in which a relatively large amount of chemical solution is stored and a small amount in which a relatively small amount of chemical solution is stored. The common reagent containers (common reagent vials) 7 are provided with a place for setting the required number of each. In addition, a place for setting the required number of solvent containers (gallon bins) 8 in which a solvent is stored is provided beside the reaction block 1, and each of the set solvent containers 8 is connected by a liquid feeding line 9. The syringe 4 is configured to be connectable. The operator sets the frequent reagent container 6, the regular reagent container 7, and the solvent container 8 to the apparatus. The reagents and solvents stored in these containers 6, 7, and 8 correspond to the reaction liquid in the present invention.
[0017]
In addition, as shown in FIG. 4, individual position addresses are assigned to the set positions of the containers 6, 7, 8 and the reaction container 2. FIG. 4 shows a case where six frequent reagent containers 6, 36 regular reagent containers 7, four solvent containers 8, and 96 reaction containers 2 can be set. And, for example, each container 6, 7, 8 and reaction container with alphabetical characters and numbers appended in the vertical and horizontal directions of the set location (α, β, γ, δ) for each type of container 6, 7, 8 The position address of each set location (α, β, γ, δ) for each of the two types is determined. Specifically, among the six set locations (α) of the frequent reagent container 6, the position address of the set location at the upper left in FIG. 4 is α (A, 1). Similarly, among the 36 set locations (β) of the regular reagent container 7, the position address of the lower right set location in FIG. 4 is β (D, 9), and the set location (γ) of the solvent container 8 is 4, the position address of the second set location from the top is γ (B, 1), and among the 96 set locations (δ) of the reaction vessel 2, the location address of the set location at the lower right of FIG. 4 is δ (H, 1).
[0018]
When the chemical solution is dispensed and supplied to the reaction container 2, the syringe 4 is moved to the position of the frequent reagent container 6 or the regular reagent container 7 in which the chemical solution to be dispensed is stored, as shown by the dotted line in FIG. After the reagent is sucked from the syringe needle 4a, the reagent in the syringe 4 is moved to the position of the reaction container 2 to be dispensed, and then the sucked reagent is injected from the syringe needle 4a into the reaction container 2.
[0019]
When the solvent is dispensed and supplied to the reaction container 2, the solvent is introduced into the syringe 4 from the solvent container 8 in which the solvent to be dispensed is stored via the liquid feeding line 9, and the syringe 4 is reacted to the solvent dispensing target. The solvent is moved to the position of the container 2 and the introduced solvent is injected into the reaction container 2 from the syringe needle 4a. Normally, as described above, the liquid is aspirated at the position of the frequent reagent container 6 or the common reagent container 7, and the syringe 4 is moved so as to inject the liquid at the position of the reaction container 2. In the case of the apparatus, conversely, the liquid can be sucked at the position of the reaction container 2 and the syringe 4 can be moved so as to inject the liquid at the position of the frequent reagent container 6 or the common reagent container 7. Yes.
[0020]
In the case of the reaction block 1 of the example apparatus, as shown in FIG. 3, the sheet-like common septum 10 that covers the injection port of each reaction vessel 2 and each reaction vessel 2 so as to close the bottom side inside of the reaction vessel 2. A pressure permeable filter 11 attached to each reaction vessel and a drain 12 connected to each reaction vessel 2 so as to communicate with the bottom of the reaction vessel 2 are provided, and a gas cylinder is provided on the inlet side of the reaction vessel 2. A gas introduction line 13 for introducing pressurized gas (for example, high-pressure inert gas) from GB is provided. Therefore, the syringe needle 4a penetrates through the common septum 10 and enters the reaction container 2 at the time of reagent injection or solvent injection. In addition, each reaction vessel 2 is provided with an appropriate amount of resin particles 14 for solid-phase reaction, and an open / close valve 15 is provided at the end of the gas introduction line 13. When the pressurized gas is introduced into the valve, the on-off valve 15 is closed.
[0021]
In addition, the example apparatus is provided with a vibration unit 16 that vibrates the reaction block 1 during the synthesis reaction and shakes the resin particles 14 in each reaction vessel 2, and in each reaction vessel 2 during the reaction process. A discharge tray 17 for discharging generated unnecessary materials, and a recovery block 18 for recovering the synthetic compound obtained in each reaction vessel 2 by the synthesis reaction for each reaction vessel 2 are also located at the lower position of the reaction block 1 respectively. It is arranged to be movable between standby positions.
[0022]
In the synthesis process in the automatic synthesizer of the example, a solid phase reaction proceeds in the resin particles 14 of each reaction vessel 2 to which necessary reagents and solvents are dispensed and supplied, and the target synthetic compound is obtained. After completion of the synthesis reaction, an extraction (acidic) chemical solution for taking out the compound produced in the resin particles 14 is fed from the injection port. When the compound is extracted, the pressurized gas of the gas cylinder GB is introduced from the gas introduction line 13, and the synthetic compound is allowed to pass through the pressurized liquid-permeable filter 11 together with the extraction chemical solution and is pushed from the drain 12 to the recovery block 18. .
[0023]
Next, the configuration of the control system of the embodiment apparatus will be described. In the case of the automatic synthesizing apparatus of the embodiment, a video display monitor 19 that displays various screens necessary for the operation of the apparatus and a control unit 20 that executes various controls necessary for the operation of the apparatus in a timely manner are provided. In addition to being connected to input operation devices such as a keyboard (operating console) 21 and mouse (pointing device) 22 for input, functions such as liquid chromatography and mass spectrometry are provided based on a synthesis protocol described later. It has a characteristic configuration for generating an analysis schedule composed of input information for analyzing a synthetic compound by an analyzer. Hereinafter, this characteristic configuration will be specifically described.
[0024]
The control unit 20 of the embodiment apparatus has a screen display unit 23 that is displayed on a screen and a video display monitor 19 necessary for the operation of the apparatus, and a composition that stores a composition protocol that is input and set in advance by an input operation device such as a keyboard 21 and a mouse 22. A protocol storage unit 24, and a dispensing control unit 25 for sending a command signal for executing a dispensing operation according to a dispensing procedure in the synthesis protocol stored in the synthesis protocol storage unit 24 to the liquid dispensing unit 3. A synthesis protocol analysis unit 26 that analyzes a synthesis protocol used to generate a synthetic compound and extracts input information to be input to the analyzer from the synthesis protocol; and input information to be input to the analyzer An input information storage unit 27 that stores input information not included in the synthesis protocol, and input information extracted from the synthesis protocol. And a analysis schedule generation unit 28 that generates a composed analysis schedule input information to be input to the analyzer on the basis of the input information read from the fine input information storage unit 27.
[0025]
The screen display unit 23 is a synthesis protocol setting screen for an operator to set a synthesis protocol, an analysis method setting screen for setting an analysis method in an analyzer, a protocol analysis screen for displaying analysis contents of a synthesis protocol, Various screens such as a wizard-type screen for inputting input information necessary for the analyzer are displayed as appropriate.
[0026]
The synthesis protocol storage unit 24 stores the synthesis protocol set using the keyboard 21 and the mouse 22 in accordance with the synthesis protocol setting screen displayed on the video display monitor 19. In this synthesis protocol, steps to be performed when performing a plurality of types of synthesis reactions, an execution order of each step, a detailed procedure of each step, and the like are set. For example, these processes include a dispensing process for dispensing a predetermined chemical solution into a predetermined reaction container 2, a stirring process for shaking the reaction rack 1 to stir the reaction container 2, the reaction container 2 and the syringe 4 and the like. A draining process for draining the solution of the solution, a purging process for purging the solution in the syringe 4, a container washing process for washing each container, a standby process for waiting the apparatus, a temperature adjusting process for raising or lowering the temperature of the reaction rack 1, etc. There is a process. For example, in the dispensing process, from the container 6, 7, 8 set at the position address of which set location (α, β, γ), to what position address (δ) of which reaction vessel 2 is set, how much Information on whether to dispense a reagent or a solvent of a certain amount is included. For example, in a certain dispensing step, 1 to 4 cc of the normal reagent from the normal reagent container 7 set in the setting place β (B, 5) of the normal reagent container 7 and the setting place δ (B, 7) to the reaction container 2 are set. Dispense into the reaction vessel 2 set at (E, 7), and set the solvent vessel 8 or solvent set at the setting location γ (C, 1) of the solvent vessel 8 by 2 cc to the setting location δ (B, 7 ) To (E, 7), the procedure of dispensing into the reaction container 2 set is set. Moreover, in a certain stirring process, the procedure which rotates an electric motor at 900 rpm and shakes the reaction rack 1 for 1 hour is set. Similarly, the control procedure of the apparatus according to the process is set also in each other process. In this way, a synthesis protocol is configured by setting parameters necessary for each of these steps.
[0027]
The dispensing control unit 25 transmits a command signal corresponding to the dispensing process included in the synthesis protocol to the liquid dispensing unit 3. In addition, command signals corresponding to other steps included in the synthesis protocol are also sent to corresponding mechanisms on the reaction system side. And the synthetic compound according to each condition is each produced | generated by each reaction container 2 by performing each process included in a synthetic protocol.
[0028]
The synthesis protocol analysis unit 26 reads out the synthesis protocol stored in the synthesis protocol storage unit 24 and used to generate the synthetic compound to be analyzed by the analyzer, and is included in the input of the synthesis protocol for inputting to the analyzer. Information is taken out.
[0029]
The input information storage unit 27 displays an analysis method setting screen for setting an analysis method in the analysis device displayed on the video display monitor 19, a protocol analysis screen for displaying analysis contents of the synthesis protocol, and input information necessary for the analysis device. For storing input information such as information set using the keyboard 21 and mouse 22 in accordance with a wizard-type input screen for setting parameters, and initial values of various parameters stored in advance according to the analyzer It is.
[0030]
The analysis schedule generation unit 28 generates an analysis schedule in a table format for input to the analysis apparatus based on the input information extracted by the synthesis protocol analysis unit 26 and the input information stored in the input information storage unit 27. To do. This analysis schedule is data in a table format in which input information such as a sample name, a file name in which an analysis method is stored, and an analysis result storage destination file name are set for each synthetic compound. The input information extracted by the synthesis protocol analysis unit 26 corresponds to the first input information in the present invention, and the input information read from the input information storage unit 27 corresponds to the second input information in the present invention.
[0031]
The configuration of the control system of the above-described embodiment apparatus is built around a personal computer and software (computer program). The synthesis protocol storage unit 24, the input information storage unit 27, and the like in the control unit 20 are configured by a storage device such as a RAM or a ROM, and include a screen display unit 23, a dispensing control unit 25, a synthesis protocol analysis unit 26, an analysis. The process control unit such as the schedule generation unit 28 includes a CPU that executes a program for performing these processes. The keyboard 21 or mouse 22 corresponds to the input means or instruction means in the present invention. The synthesis protocol analysis unit 26 corresponds to the synthesis protocol analysis unit in the present invention, the input information storage unit 27 corresponds to the input information storage unit in the present invention, and the analysis schedule generation unit 28 corresponds to the analysis schedule generation unit in the present invention.
[0032]
Next, the processing of the characteristic part of the present invention in the embodiment apparatus having the above configuration will be described with reference to the flowchart shown in FIG.
[0033]
Step S1 (Protocol Analysis Screen Display)
The operator operates the keyboard 21 and the mouse 22 to display a protocol analysis screen 60 as shown in FIG. 6 on the video display monitor 19. The protocol analysis screen 60 includes a matrix display area 61 having a mode corresponding to each reaction vessel 2 of the reaction block 1, a synthesis protocol used for a predetermined reaction vessel 2, a generated analysis schedule, and an analysis result. And the like, and a tag display area 62 displayed with each tag. Hereinafter, a case where the synthesis protocol is displayed in the tag display area 62 is referred to as a synthesis protocol display area 63, and a case where the analysis schedule is displayed in the tag display area 62 is referred to as an analysis schedule display area 64.
[0034]
Step S2 (Analysis schedule generation range is set)
In order to analyze the synthetic compound produced in any reaction container 2 of the reaction block 1, the operator designates the area on the matrix display area 61 corresponding to the arbitrary reaction container 2 with the keyboard 21 or the mouse 22. To do. Thereby, the production | generation range of the analysis schedule for analyzing the synthetic compound produced | generated in the reaction container 2 corresponding to the area | region can be set. Specifically, a mouse cursor (not shown) is operated with the keyboard 21 or the mouse 22, and an area surrounded by, for example, (B, 7) to (E, 10) on the matrix display area 61 is designated with the mouse cursor. When an area corresponding to an arbitrary reaction vessel 2 is designated in this way, the protocol analysis unit 26 reads the synthesis protocol used for the arbitrary reaction vessel 2 from the synthesis protocol storage unit 24, and determines the synthesis protocol. The information is displayed in the synthesis protocol display area 63. If the entire matrix display area 61 is indicated, the entire synthesis protocol is displayed, and if a single reaction vessel 2 is selected, the synthesis protocol used for that reaction vessel 2 is displayed. Step S2 corresponds to the function of the instruction means in the present invention.
[0035]
Step S3 (Set input information of analyzer)
The operator displays a schedule creation wizard screen 70 as shown in FIG. 7 in order to input the input information of the analyzer that cannot be extracted from the above-described synthesis protocol. In the schedule creation wizard screen 70, a storage file name in which an analysis method is stored is set, and data processing such as LC (liquid chromatography) quantitative calculation and MS (mass spectrometry) quantitative calculation is set. The schedule creation wizard screen 70 is composed of a plurality of types of screens (not shown). In these screens, for example, in addition to the items shown in FIG. And a screen for setting sample names of synthetic compounds. These screens can be arbitrarily displayed by clicking the button 71 or 72. When the operator sets input information of necessary items, the operator clicks the completion button 73 on the schedule creation wizard screen 70. When the completion button 73 is clicked, the synthesis protocol analysis unit 26 temporarily stores the input information set on the schedule creation wizard screen 70 in the input information storage unit 27. Step S3 corresponds to the function of the input means in the present invention.
[0036]
Step S4 (analysis of synthesis protocol)
When the above-described completion button 73 is clicked, the synthesis protocol analysis unit 26 further analyzes the synthesis protocol of each reaction vessel 2 corresponding to the area designated in the matrix display area 61 and is necessary for creating an analysis schedule. The correct input information. The input information extracted from the synthesis protocol is information such as the number of synthetic compounds to be analyzed, for example. Step S4 corresponds to the function of the synthesis protocol analysis means in the present invention.
[0037]
Step S5 (generation of analysis schedule)
When the analysis by the synthesis protocol analysis unit 26 is finished, the analysis schedule generation unit 28 generates a table format analysis schedule based on the extracted input information and the input information stored in the input information storage unit 27. . As shown in the analysis schedule display area 64 shown in FIG. 8, this analysis schedule has the number of rows corresponding to, for example, the number of synthetic compounds, for example, 16 which is input information extracted from the synthesis protocol. The data in the table format in which the row direction is the number of columns for other input information to be input to the analyzer. Step S5 corresponds to the function of the analysis schedule generation means in the present invention.
[0038]
Specifically, the analysis schedule generation unit 28 associates the sample name, analysis method file, dilution rate, and analysis result stored in the input information storage unit 27 with the first synthetic compound to be analyzed. Writes various input information such as saved file names in the line direction. In addition, in the lower row of each first input information, various input information such as sample name, analysis method file, dilution rate, analysis result storage file name, etc. corresponding to the second synthetic compound Is written in the row direction. Similarly, a table-type analysis schedule is generated by sequentially writing each input information in the row direction for each synthetic compound to be analyzed while sequentially changing the rows. When the analysis schedule generation for all the synthetic compounds is completed, the analysis schedule generation unit 28 stores the analysis schedule in a file with a predetermined file name and displays it in the analysis schedule display area 64. Step S5 is ended. Note that FIG. 8 shows a case in which each piece of input information in the column direction has the same value, but the present invention is not limited to this, and each piece of input information in the column direction can have a different value.
[0039]
The analysis schedule generated in steps S1 to S5 described above is read out by an analysis device connected through a network, for example. The analyzer analyzes each synthetic compound according to the read analysis schedule.
[0040]
As described in detail above, according to the automatic synthesis apparatus of the embodiment, based on the input information included in the synthesis protocol used when the synthetic compound is generated and the input information stored in the input information storage unit 27. Since a table-type analysis schedule is generated, a series of processes from synthesis to analysis is more efficient than in the case where the operator manually inputs each piece of input information for each synthetic compound on the analyzer side. Can be done well. In addition, since the schedule creation wizard screen 70 is used when setting the input information, the number of input information to be set can be reduced and input errors can be prevented.
[0041]
The present invention is not limited to the above-described embodiment, and can be modified as follows.
(1) In the above-described embodiment, the screens of the modes shown in FIGS. 6 to 8 are used. However, the present invention is not limited to this. It can also be configured to display in a window.
[0042]
(2) In the above-described embodiment, the case where the analysis schedule is generated after the synthetic compound is generated has been described. However, the present invention is not limited to this. For example, before the synthetic compound is generated, the analysis schedule will be used. An analysis schedule can be generated in advance by using a synthesis protocol.
[0043]
(3) In the automatic synthesizer of the above-described embodiment, the reaction system is one set, but a device having a configuration in which two sets of the same reaction system controlled by one control system are provided is a modification. As mentioned.
[0044]
(4) The example apparatus was an organic automatic synthesizer, and the compound was synthesized by solid phase reaction. However, the apparatus of the present invention may be an inorganic automatic synthesizer, or a liquid phase An apparatus configured to synthesize a compound by reaction may be used.
[0045]
【The invention's effect】
As is clear from the above description, the present invention has the following effects.
That is, according to the first aspect of the invention, the analysis schedule is based on the first input information obtained by analyzing the synthesis protocol and the second input information stored in the input information storage means. Therefore, a series of processes from generation to analysis of a synthetic compound can be performed efficiently. Furthermore, since the first input information is extracted from the synthesis protocol used at the time of generating the synthetic compound, it is possible to eliminate input mistakes in the first input information.
[0046]
According to the second aspect of the invention, since the second input information is input by the input means, it is possible to cope with various input information for input to the analyzer.
[0047]
Further, according to the invention described in claim 3, since the analysis schedule is generated for the synthetic compound generated in an arbitrary reaction vessel instructed by the instruction means, only the synthetic compound that needs to be analyzed can be analyzed. As a result, processing from synthesis to analysis can be performed more efficiently.
[Brief description of the drawings]
FIG. 1 is a block diagram illustrating an overall configuration of an automatic synthesis apparatus according to an embodiment.
FIG. 2 is a plan view showing a configuration of a reaction system of the example apparatus.
FIG. 3 is a schematic view showing a main configuration of a reaction block of the example apparatus.
FIG. 4 is a diagram showing a position address of a setting place of each container.
FIG. 5 is a flowchart for generating an analysis schedule.
FIG. 6 is a diagram showing a protocol analysis screen.
FIG. 7 is a diagram showing a schedule creation wizard screen.
FIG. 8 is a diagram illustrating a state in which an analysis schedule is displayed on a protocol analysis screen.
[Explanation of symbols]
1 ... Reaction block
2… Reaction vessel
3 ... Liquid dispensing part
19 ... Video display monitor
21 ... Keyboard
22 ... Mouse
23 ... Screen display section
24 ... Synthesis protocol storage unit
25 ... Dispensing control unit
26 ... Synthesis protocol analyzer
27 ... Input information storage unit
28… Analysis schedule generator

Claims (3)

A reaction block in which a plurality of reaction vessels for performing a synthesis reaction are arranged, a dispensing means for dispensing a reaction solution into each reaction vessel of the reaction block, and a reaction set in order to perform a synthesis reaction in the reaction vessel Synthesis protocol storage means for storing a synthesis protocol that is a synthesis procedure to be performed, and based on the synthesis protocol, a plurality of types of reaction liquids are dispensed into the reaction vessel to perform synthesis, In the automatic synthesizer for generating a synthetic compound in the first step, a synthesis protocol used for generating the synthetic compound in the reaction vessel is analyzed and input to an analyzer for analyzing the generated synthetic compound. A synthesis protocol analysis means for extracting input information from the synthesis protocol; and a second input that is input to the analyzer and not included in the synthesis protocol. An input information storage means for storing information, a first input information retrieved from the synthetic protocol, based on the second input information read from the input information storage means, said to analyze the synthetic compound An automatic synthesizing apparatus comprising: an analysis schedule generating means for generating an analysis schedule which is data for operating the analysis apparatus.   2. The automatic synthesizing apparatus according to claim 1, further comprising an input unit for inputting the second input information, wherein the input information storage unit stores the second input unit input by the input unit.   3. The automatic synthesizer according to claim 1 or 2, further comprising an instruction means for instructing an arbitrary reaction container in the reaction block, wherein the synthesis protocol analysis means First input information for analysis is extracted from the synthesis protocol, and the analysis schedule generation unit is instructed by the instruction unit based on the first input information and the second input information. An automatic synthesizer that generates an analysis schedule for analyzing a synthetic compound produced in any reaction vessel.

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