JP4325179B2 - Non-invasive biological component quantification device - Google Patents

Description

[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a quantification device for non-invasive biological component by utilizing the absorption of light in the near infrared region to analyze body fluid component concentration of a chemical component in a biological tissue or body fluids, specifically Relates to an apparatus for measuring blood glucose level by quantitative analysis of glucose concentration in skin tissue.
[0002]
[Prior art]
Since the glucose concentration in the skin tissue has a high correlation with the glucose concentration (blood glucose level) in the blood, it is used as a substitute value for determining the blood glucose level. As non-invasive measurement of the glucose concentration, light from a light source (near-infrared light) composed of a halogen lamp is focused by a condenser lens and irradiated on the subject 8, and the inside of the subject 8 is transmitted or diffusely reflected. In some cases, the obtained light is spectrally separated by a diffraction grating or the like, then received by a light receiving element unit, and the glucose concentration is calculated based on a biological signal obtained by the light receiving element unit. In this case, the reference light signal is obtained by irradiating the light from the light source onto a standard plate such as a ceramic plate and receiving the light reflected by the standard plate, and the glucose concentration changes based on the reference light signal and the biological signal. Analyzes trace changes in absorbance in the spectrum derived from it, and calculates the glucose concentration.
[0003]
For example, in the glucose concentration quantification method and apparatus disclosed in Japanese Patent Laid-Open No. 2000-131322 (Patent Document 1), as shown in FIG. 22, a light source 61 composed of a halogen lamp and light from the light source 61 are focused. The condensing lens 62, the optical fiber bundle probe 63 for irradiating the subject with the light passing through the condensing lens 62 and receiving the light transmitted through or diffusely reflected in the subject, and the light after the light is dispersed Glucose concentration based on a diffraction grating unit 64 containing a diffraction grating, an InGaAs array type light receiving element unit 65 for detecting light dispersed by the diffraction grating unit 64, and a signal obtained by the array type light receiving element unit 65 A unit composed of an arithmetic unit 66 that calculates the above is shown.
[0004]
In this case, at the time of spectrum measurement, the light from the light source 61 irradiates a standard plate such as a ceramic plate through the optical fiber bundle probe 63 and receives the light (reference light signal) reflected by the standard plate, and then touches it. Using a positioning jig for fixing the position, the sensing portion of the optical fiber bundle probe 63 is brought into contact with the skin surface at a contact pressure of 100 to 500 gf / cm ² and transmitted or diffusely reflected in the skin tissue ( (Biological signal) is received, and based on the obtained reference signal and biological signal, the calculation unit 66 analyzes the minute change in absorbance in the spectrum resulting from the glucose concentration change, and calculates the glucose concentration. At this time, generally, signals of all pixels (example 256 pixels) in the analysis wavelength range obtained by the multichannel detector are used.
[0005]
By the way, since the glucose concentration is as small as several tens to several hundreds mg / dl, in order to determine the glucose concentration based on the light (biological signal) transmitted or diffusely reflected through the skin tissue, the above light is used as S / N. It is important to capture well, and for this reason, it has the resolution that can correctly capture the spectral change according to the glucose concentration change while suppressing the absorbance baseline fluctuation as much as possible to increase the stability of the spectrum measurement It must be left as. Therefore, in the above configuration, a spectrum of 1000 nm to 2500 nm is used as the wavelength region (actually, it is assigned to the number of light receiving element arrays (example: 256 elements)), and the glucose concentration is quantitatively calculated and estimated by multivariate analysis. ing.
[0006]
[Patent Document 1]
JP 2000-131322 A
[Problems to be solved by the invention]
The above-mentioned system in which analysis for estimating the glucose concentration is performed after all signals within the analysis wavelength range obtained by the multi-channel detector are converted into absorbance is inevitably a system configuration. In addition, a light source that must generate continuous near-infrared light requires a halogen lamp or the like, and countermeasures against heat are difficult. In addition, a spectroscopic unit composed of a diffraction grating or the like for decomposing continuous light into a spectrum is required. In addition, the multi-channel detector, which is a light receiving element, may not be accurately reflected because the characteristics of each pixel are not uniform. This is a factor for obtaining good analysis accuracy in estimation.
[0008]
The present invention has been made in consideration of the above points, and an object of the present invention is to provide a non-invasive biological component quantification apparatus that is small and power-saving.
[0009]
[Means for Solving the Problems]
Accordingly, the present invention is a quantitative device that non-invasively quantifies biological components, a light source unit that sequentially emits light of a plurality of different wavelengths in the near-infrared wavelength region 1000 nm to 2500 nm, and the light to the living body. A probe unit that irradiates and receives reflected light from the living body or transmitted light that has passed through the living body, a light receiving unit that converts light that has entered the probe unit into an electrical signal, and the absorbance for each wavelength obtained by the light receiving unit The light source unit includes a light emitting diode array in which a plurality of light emitting diodes that output light having different wavelengths and a micro lens corresponding to each light emitting diode are arranged. The light source part and the light receiving part are arranged in close proximity, and the optical path from the light source part to the light receiving part through the probe part has a folded shape. Especially characterized parts and the respective parts while is integrated by connected by a light guide unit comprising a light guide plate and between the light receiving portion and the probe of the probe portion is formed as a single assembly unit Yes. By sequentially irradiating the subject with light of different wavelengths, a light emitting diode is used as the light source part, the light source part and the light receiving part are brought close to each other, the optical path is folded back, and an optical waveguide plate is used to make a small assembly It is formed as a unit.
[0010]
It is preferable that a reference light guiding unit that guides light of each wavelength to the light receiving unit without passing through the living body is used, and the absorbance of the reference light is used in calculating the biological component concentration.
[0012]
Light source unit and may be assumed with a light bending portion for bending the light between and between the light receiving portion and the probe of the probe portion.
[0013]
If the light output from the light source section is provided with a branching section that divides the light into two for biological measurement and reference light measurement, the reference light measurement is facilitated.
[0014]
The branching portion can be formed by an optical switch, or can be formed by a mirror that extracts a part of light output from the light source portion for reference light.
[0015]
The mirror at this time is a mirror for reflecting one side of the light from the probe unit to the light receiving unit, and the other side is a mirror for taking out part of the light output from the light source unit for reference light. A double-sided mirror can be used suitably, and a part of the light output from the light source unit is extracted for reference light and directed to the light receiving unit in the same direction as the light receiving unit that receives the light from the probe unit be able to. Further, a mirror may be formed by an optical switch that switches between an optical path for reflecting light from the probe unit to the light receiving unit and an optical path for extracting a part of the light output from the light source unit for reference light.
[0016]
Of course, it is preferable that the reference light guide portion is also incorporated in the assembly unit.
[0018]
The light guide unit disposed between the light emitting unit and the probe is preferably formed of an optical waveguide plate provided with an optical coupling waveguide that couples light inputs from the respective light emitting diodes into one light output.
[0019]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, the present invention will be described in detail based on an embodiment. FIG. 1 shows a quantitative device according to the present invention. The quantitative device formed as an assembly unit includes a light emitting / receiving unit 1, a light guide unit, and a light guide unit. The units 2 and 3, the probe unit 4, the light collecting units 5 and 6, and the reference light unit 7, and other units 1 to 6 except the reference light unit 7 configured as an adapter are integrated. Yes.
[0020]
As shown in FIG. 2A, the light receiving / emitting unit 1 corresponds to the light emitting diode array 10 in which a plurality (eight in the illustrated example) of light emitting diodes LD1 to LD8 are arranged, and to each of the light emitting diodes LD1 to LD8. A lens array 11 in which condensing microlenses are arranged, a single light receiving element 12 shown in FIG. 2 (c), and control of light reception and emission, and a biological component concentration is calculated based on the output of the light receiving element 12. Each of the above-described members is mounted on a circuit board 16 that is a three-dimensionally shaped circuit board. The circuit board 16 has a stepped portion. The light emitting diode array 10 and the lens array 11 are disposed on the upper stage side, and the light receiving element 12 and the microlens 13 are disposed on the lower stage side.
[0021]
The light emitting diodes LD1 to LD8 in the light emitting diode array 10 emit light having different wavelengths in the near infrared wavelength range of 1000 nm to 2500 nm. For example, LD1: 1300 nm, LD2: 1400 nm, LD3: 1500 nm, LD4: 1550 nm. , LD5: 1600 nm, LD6: 1700 nm, LD7: 1800 nm, LD8: 1900 nm. Note that the number of light-emitting diodes and the wavelength band allocation in the light-emitting diode array 10 are not limited to the above example, and are set according to the required accuracy. it can.
[0022]
Of the two light guide units 2 and 3, the light guide unit 2 combines an optical coupling waveguide 21 that combines eight optical inputs into one optical output, and an optical output coupled by the optical coupling waveguide 21. Is formed by an optical waveguide plate provided with a mirror 22 (see FIG. 2B) that deflects substantially at right angles, and the eight light inputs located on one end face in the longitudinal direction are the light receiving / emitting unit 1 The lens array 11 is connected to the light emitting / receiving unit 1 so as to face the eight microlenses.
[0023]
The probe unit 4 is disposed via a condensing unit 5 provided with a condensing lens immediately below the mirror 22 of the light guiding unit 2. As shown in FIGS. 2 (d) and 3, the probe unit 4 has a diameter of about the projection member 40 as well as concentrically arranged a plurality of which is constituted by a cylindrical resin or metallic tube of 200 [mu] m (12 present in the illustrated embodiment), with a cylindrical resin or metallic tube with a diameter of about 200 [mu] m at its center The light projecting / receiving unit 4a having the light receiving material 41 thus configured is provided, and a mirror 42 is provided immediately above the light receiving material 41 in the light projecting / receiving unit 4a. The distance L between the light projecting material 40 and the light receiving material 41 is suitably in the range of 0.2 mm to 2.0 mm, and is 650 μm in this example.
[0024]
The light guide unit 3 controls light guide between the light receiving element 12 in the light receiving and emitting unit 1 and the mirror 42 in the probe unit 4, and is formed of an optical waveguide plate like the light guide unit 2. A condensing unit 6 having a condensing lens is disposed between the probe unit 4 and the probe unit 4.
[0025]
The light guided from the light emitting diode array 10 of the light receiving / emitting unit 1 to the light guide unit 2 through the lens array 11 enters one end of the light projecting material 40 of the probe unit 4 via the mirror 22 and the light collecting unit 5 and projects. The light material 40 is emitted from the other end. Light entering the light receiving material 41 of the probe unit 4 from the other end side is guided through the micro lens 13 to the light receiving element 12 in the light receiving / emitting unit 1 through the mirror 42, the light collecting unit 6, and the light guiding unit 3. FIG. 4 is an explanatory diagram of the optical path.
[0026]
The reference light unit 7 configured as an adapter is detachably attached to the tip of the light projecting / receiving unit 4a of the probe unit 4, and reflects and emits light emitted from the other end of the light projecting material 40. A reflection surface that is incident on the other end of the material 41 is provided.
[0027]
In the above-described quantitative device configured as described above and formed as a small integrated assembly unit, the biological component is quantitatively determined as follows.
[0028]
First, the reference light unit 7 is set in the probe unit 4 and spectrum measurement of the reference light is started. At this time, the light emitting diodes LD1 to LD8 sequentially emit light in the order of, for example, LD1.fwdarw.LD2, .fwdarw.LD3.fwdarw.LD4.fwdarw.LD5.fwdarw.LD6.fwdarw.LD7.fwdarw.LD8 at intervals of about 1 second or less. This circulation switching signal is also transmitted to the single-element light receiving element 12, and also plays a role of resetting each time the light source is switched.
[0029]
The light from the light emitting diode LD1 passes through the lens array 11, the light guide unit 2, and the light collecting unit 5, reaches the probe unit 4, and is emitted from the light projecting material 40. The reference measurement light reflected by the reference light unit 7 is received by the light receiving material 41 and the mirror. 42 enters the light receiving element 12 through the light collecting unit 6, the light guiding unit 3, and the microlens 13. The output of the light receiving element 12 is A / D converted and stored in the calculation unit 15 as a reference photoelectric conversion signal Ref.
[0030]
Next, turning off the light emitting diode LD1 and resetting the single-element light receiving element 12 and then turning on the light emitting diode LD2 to obtain the reference photoelectric conversion signal Ref are repeated until the light emission of the light emitting diode LD8 is completed. . As a result, the calculation unit 15 stores the reference photoelectric conversion signal Ref corresponding to the eight wavelengths in the calculation unit 15.
[0031]
Thereafter, the reference light unit 7 is removed from the probe unit 4, the probe unit 4 is brought into contact with the skin surface of the living body, and measurement is started. At this time, the light emitting diodes LD1 to LD8 are sequentially caused to emit light in the same procedure as the reference light spectrum measurement, and the living body measurement light emitted from the light projecting material 40 and transmitted and diffused and reflected by the living body is used. The calculation unit 15 sequentially stores the biological photoelectric conversion signals Sig corresponding to the eight wavelengths.
[0032]
From the measured reference photoelectric signal Ref and bioelectric signal Sig, the absorbance Abs is
Abs = log ₁₀ (Ref / Sig)
Can be obtained. In this example, since measurement is performed using light of eight wavelengths, eight absorbance Abs can be measured.
[0033]
Abs1300nm = log ₁₀ (Ref / Sig)
Abs1400nm = log ₁₀ (Ref / Sig)
Abs1500nm = log ₁₀ (Ref / Sig)
Abs1550nm = log ₁₀ (Ref / Sig)
Abs1600nm ＝ log ₁₀ (Ref / Sig)
Abs1700nm ＝ log ₁₀ (Ref / Sig)
Abs1800nm = log ₁₀ (Ref / Sig)
Abs1900nm = log ₁₀ (Ref / Sig)
Based on these eight absorbance Abs information, the calculation unit 15 calculates a biological component concentration based on a biological component concentration calculation formula stored in advance, and outputs the calculation result to an external display device. Display. 12 to 16 show flowcharts for the above operation.
[0034]
FIG. 5 shows another example. This eliminates the need to attach or detach the reference light unit 7 as an adapter when measuring the reference light. The probe unit 4 has a light projecting / receiving part 4b configured similar to the light projecting / receiving part 4a adjacent to the light projecting / receiving part 4a. Are juxtaposed. The light projecting / receiving unit 4b includes a reflection plate 44 on the bottom surface that reflects light emitted from the light projecting material 40 to the light receiving material 41 side.
[0035]
The light guide unit 2 here includes an optical coupling waveguide 21 that uses eight optical inputs as one optical output, an optical switch 25 that selectively distributes one optical input into two optical outputs, An optical waveguide plate having mirrors 22 and 22, one mirror 22 guides one light distributed by the optical switch 25 to the light projecting / receiving unit 4 a of the probe unit 4, and the other mirror 22 is an optical switch 25. One of the distributed lights is guided to the light projecting / receiving unit 4b of the probe unit 4.
[0036]
The light guide unit 3 is reflected by the mirror 42 of the light projecting / receiving unit 4a of the probe unit 4 and passed through the light collecting unit 6 and reflected by the mirror 42 of the light projecting / receiving unit 4b of the probe unit 4 6 is formed of an optical coupling type optical waveguide plate that couples the light having passed through 6 and guides it to the light receiving element 12.
[0037]
As shown in the flow of FIGS. 17 to 21, the biological component is quantified by alternately measuring the biological measurement light and the reference light for each wavelength of light output from the light emitting diode array 10. At this time, for example, when measuring the biological measurement light and the reference light by the light of the wavelength output from the light emitting diode LD1, the light emitting diode LD1 is temporarily turned off, and the light receiving element 12 is reset and the optical switch 25 is switched. In addition, when switching the light emitting diode to emit light, the light receiving element 12 is reset and the optical switch 25 is switched. Since the reference light unit 7 is not required to be attached or detached, and the reference light can be measured while the probe unit 4 is pressed against the living body, the biological component can be quantified more quickly.
[0038]
7 and 8 show other examples. Although only the light projecting / receiving unit 4a is provided in the probe unit 4, the mirror 42 provided in the light projecting / receiving unit 4a uses a mirror with both surfaces being mirror surfaces, and the light collecting unit 6 'on the opposite side to the light guide unit 3. , A light guide unit 3 ′, and a light receiving unit 8. A part of the light output from the light emitting diode array 10 and entering the light projecting and receiving unit 4 a through the light guiding unit 2 and the light collecting unit 5 is reflected on the mirror 42. Thus, the light is reflected toward the light collecting unit 6 ′ and the light guide unit 3 ′ so as to be guided to the single element type light receiving element of the light receiving unit 8. Other configurations are substantially the same as those shown in FIG. The reference light can be measured simultaneously with the biological measurement light by the mirror 42 and the light receiving unit 8 which are double-sided mirrors. Moreover, since the light brightness at the time of measurement can be measured simultaneously, more accurate measurement is possible. A mirror other than the mirror 42 may be provided in the probe unit 4 so that a part of the light is guided to the light receiving unit 8.
[0039]
Further, as shown in FIG. 9, as a mirror 42, a part of the light from the light emitting diode array 10 is used in the same direction as the reflection direction of the light from the light receiving material 41, that is, the light receiving and emitting unit 1 of the light receiving and emitting unit 1. You may make it reflect in a direction. Even in this case, since the light intensity at the time of measurement can be measured at the same time, it is possible to measure with higher accuracy. It is advantageous. The mirror 42 may be composed of a plurality of mirrors instead of the integral symmetric mirror. In the illustrated example, two light receiving elements 12 and 12 are arranged in the light emitting / receiving unit 1 so as to receive the biological measurement light and the reference light, respectively, so that the biological measurement light and the reference light can be measured simultaneously. However, the light guide unit 3 may be an optical coupling type and may be received by a single light receiving element 12.
[0040]
Further, as shown in FIG. 10, an optical switch 45 is provided in place of the mirror 42 so that the light guided to the light receiving element 12 is a part of the light from the light emitting diode array 10 or the light from the light receiving material 41. You may make it switch. In this case, the optical path error at the time of measurement is reduced, and more accurate measurement is possible.
[0041]
FIG. 11 shows a blood glucose level measuring device 9 mainly composed of the above-described biological component quantification apparatus. In the blood glucose level measuring device 9 provided with a belt 91 for wearing on the wrist and a display unit 92 made of a liquid crystal display, the tip of the probe unit 4 comes into contact with the skin when the belt 91 is used for wearing on the wrist. If the measurement is started by operating the switch unit 93 in this state, the reference light and the biological measurement light with a plurality of wavelengths are measured by the sequential light emission of the light emitting diode array 10 as described above, The blood glucose level is calculated from the measurement result and displayed on the display unit 92. The display unit 92 is connected to the main body substrate 90 via a flexible printed circuit board, and is housed in a case in a state of being stacked on the main body substrate 90.
[0042]
【The invention's effect】
As described above, in the present invention, a light source unit that sequentially emits light having a plurality of different wavelengths in the near-infrared wavelength region 1000 nm to 2500 nm, and the reflected light from the living body A probe unit that receives transmitted light that has passed through a living body, a light receiving unit that converts light that has entered the probe unit into an electrical signal, and a biological component concentration that is calculated from the absorbance for each wavelength obtained by the light receiving unit. A light source is used for the purpose of receiving light by sequentially irradiating light of a plurality of different wavelengths, instead of spectrally analyzing light received by irradiating all near infrared light. Can be reduced in size and power consumption, and does not require a spectroscopic device on the light receiving side, and may be a single element type light receiving element for light reception, does not require a multi-channel type light receiving means, etc. As are those that can be of ultra-compact, lightweight, low power, yet the light source unit is a light emitting diode array in which a plurality of light emitting diodes for outputting lights of different wavelengths lined, micro lenses corresponding to the respective light emitting diodes The light source unit and the light receiving unit are arranged at close positions so that the optical path from the light source unit to the light receiving unit is folded back and between the light emitting unit and the probe unit. since the above-described sections while is integrated by connected by a light guide unit comprising a light guide plate between the light receiving portion and the probe are formed as a single assembly unit are those easy to handle small, especially The light source unit, the light receiving unit, and the probe can be easily integrated by the presence of the light guide unit made of the optical waveguide plate . Also, because of the remarkable progress in the development of ultra-bright light sources in this field, general-purpose infrared photodiodes, infrared phototransistors, etc. can be used as light-receiving elements from expensive InGaAs-type elements that require cooling. Since it is in the direction that can be produced, a small and inexpensive product can be obtained.
[0043]
If it has a reference light guiding part that guides light of each wavelength to the light receiving part without passing through the living body and uses the absorbance of the reference light in calculating the biological component concentration, the quantitative accuracy can be further increased. it can.
[0045]
Light directed to the light receiving portion by bending the light from the probe portion between the probe portion and the light receiving unit with a one having a light bending portion that bends the light from the light source portion between the light source portion and the probe portion those with a bent portion and a result, it is possible to reduce the whole than the optical path length, which is advantageous with respect to downsizing.
[0046]
If the light output from the light source unit is provided with a bifurcation unit that divides the light into two for biological measurement and reference light measurement, the reference light measurement can be easily performed.
[0047]
If the branch part is formed by an optical switch or a mirror that extracts part of the light output from the light source part for reference light, the reference light can be easily taken out.
[0048]
Further, the mirror is a mirror for reflecting one side of the light from the probe unit to the light receiving unit, and the other side is a mirror for taking out part of the light output from the light source unit for reference light. When a double-sided mirror is used, the reference light can be extracted without preparing a separate mirror.
[0049]
In addition, if a mirror that takes out part of the light output from the light source unit for reference light and directs it to the light receiving unit in the same direction as the light receiving unit that receives the light from the probe unit is measured, Can be performed on the light receiving unit side.
[0050]
In addition, if the mirror is formed by an optical switch that switches between the optical path for reflecting the light from the probe unit to the light receiving unit and the optical path for extracting a part of the light output from the light source unit for reference light as the mirror, a separate mirror is provided. The reference light can be taken out without preparation.
[0051]
Of course, it is preferable that the reference light guide portion is also incorporated in the assembly unit.
[0052]
When the light guide unit arranged between the light emitting section and the probe is formed of an optical waveguide plate having an optical coupling waveguide that combines light inputs from the respective light emitting diodes to produce one light output, the size is reduced. This is more advantageous.
[Brief description of the drawings]
FIG. 1 shows an example of an embodiment of the present invention, where (a) is a perspective view and (b) is an exploded perspective view.
FIGS. 2A, 2B, 2C, and 2D are perspective views of essential parts of the same. FIG.
FIG. 3 is an end view of a light projecting / receiving unit of the probe unit.
FIG. 4 is an optical path diagram of the above.
5A and 5B show another example, in which FIG. 5A is a perspective view, and FIG. 5B is an exploded perspective view.
FIG. 6 is a perspective view of the main part of the above.
FIG. 7 is an exploded perspective view of still another example.
FIG. 8 is an optical path diagram of the above.
FIG. 9 is an optical path diagram of another example.
FIG. 10 is an optical path diagram of still another example.
11A and 11B show a blood glucose level measuring device equipped with a quantitative device according to the present invention, in which FIG. 11A is a perspective view and FIG. 11B is a perspective view of internal components.
FIG. 12 is a flowchart of an operation according to an example of the embodiment of the present invention.
FIG. 13 is a flowchart of the above.
FIG. 14 is a flowchart of the above.
FIG. 15 is a flowchart of the above.
FIG. 16 is a flowchart of the above.
FIG. 17 is a flowchart of operation in another example of the embodiment of the present invention;
FIG. 18 is a flowchart of the above.
FIG. 19 is a flowchart of the above.
FIG. 20 is a flowchart of the above.
FIG. 21 is a flowchart of the above.
FIG. 22 is a block diagram of a conventional example.
[Explanation of symbols]
DESCRIPTION OF SYMBOLS 1 Light emitting / receiving unit 2 Light guide unit 3 Light guide unit 4 Probe unit 10 Light emitting diode array 12 Light receiving element 15 Calculation part

Claims (11)

A quantitative apparatus for non-invasively quantifying biological components, a light source unit that sequentially emits light having a plurality of different wavelengths in the near-infrared wavelength range of 1000 nm to 2500 nm, and irradiating the light toward the biological body A probe unit that receives light reflected from or transmitted through a living body, a light receiving unit that converts light that has entered the probe unit into an electrical signal, and a living body that is calculated from the absorbance at each wavelength obtained by the light receiving unit It consists of a calculation unit that calculates the component concentration ,
The light source unit is formed of a light emitting diode array in which a plurality of light emitting diodes that output light having different wavelengths are arranged, and a lens array in which microlenses corresponding to the respective light emitting diodes are arranged,
The light source unit and the light receiving unit are arranged in close proximity, and the optical path from the light source unit through the probe unit to the light receiving unit has a folded shape, and between the light emitting unit and the probe unit and between the light receiving unit and the probe A noninvasive living body component quantification apparatus, wherein the above-mentioned parts are formed as one assembly unit by being integrated by connection by a light guide unit comprising an optical waveguide plate .   The reference light guide unit that guides the light of each wavelength to the light receiving unit without passing through the living body, and uses the absorbance of the reference light in calculating the biological component concentration. Noninvasive biological component quantification device. 3. The noninvasive living body component quantification apparatus according to claim 1, further comprising a light bending portion that bends light between the light source portion and the probe portion and between the light receiving portion and the probe . 3. The noninvasive living body component quantification apparatus according to claim 2, further comprising a branching unit that splits the light output from the light source unit into two for biological measurement and for reference light measurement . The non-invasive biological component quantification device according to claim 4, wherein the branching portion is an optical switch . 5. The noninvasive living body component quantification apparatus according to claim 4, wherein the branching unit is a mirror that extracts part of the light output from the light source unit for reference light . The mirror is a double-sided mirror in which one side is a mirror for reflecting light from the probe unit to the light receiving unit, and the other side is a mirror for taking out part of the light output from the light source unit for reference light The noninvasive living body component quantification device according to claim 6 characterized by things. 7. The mirror according to claim 6, wherein a part of the light output from the light source part is extracted for reference light and directed to the light receiving part in the same direction as the light receiving part for receiving the light from the probe part. Non-invasive biological component quantification device. 7. The mirror is formed by an optical switch that switches between an optical path for reflecting light from the probe section to the light receiving section and an optical path for extracting a part of the light output from the light source section for reference light. The noninvasive biological component quantification apparatus as described. The noninvasive living body component quantification device according to claim 2, wherein the reference light guide is incorporated in the assembly unit . The light guide unit disposed between the light emitting unit and the probe is formed of an optical waveguide plate provided with an optical coupling waveguide that couples light inputs from the respective light emitting diodes into one light output. The noninvasive living body component quantification device according to any one of claims 1 to 10 .

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