JP4292471B2 - チオールアルキル安息香酸誘導体 - Google Patents

チオールアルキル安息香酸誘導体 Download PDF

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JP4292471B2
JP4292471B2 JP2003500046A JP2003500046A JP4292471B2 JP 4292471 B2 JP4292471 B2 JP 4292471B2 JP 2003500046 A JP2003500046 A JP 2003500046A JP 2003500046 A JP2003500046 A JP 2003500046A JP 4292471 B2 JP4292471 B2 JP 4292471B2
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benzoic acid
mercaptoethyl
pharmaceutical composition
compound
disease
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JP2005503353A (ja
JP2005503353A5 (enExample
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尚 塚本
ストーマー，ドリス
ヴィザラナ，ディルルクシ
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エーザイ コーポレーション オブ ノース アメリカ
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/62—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
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    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
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    • A61P25/04—Centrally acting analgesics, e.g. opioids
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Transplantation (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
JP2003500046A 2001-05-30 2002-05-30 チオールアルキル安息香酸誘導体 Expired - Lifetime JP4292471B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US29403601P 2001-05-30 2001-05-30
US34274601P 2001-12-28 2001-12-28
PCT/US2002/016971 WO2002096866A2 (en) 2001-05-30 2002-05-30 Thiolalkyl benzoic acid derivatives

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2009011782A Division JP2009149657A (ja) 2001-05-30 2009-01-22 チオールアルキル安息香酸誘導体

Publications (3)

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JP2005503353A JP2005503353A (ja) 2005-02-03
JP2005503353A5 JP2005503353A5 (enExample) 2005-09-02
JP4292471B2 true JP4292471B2 (ja) 2009-07-08

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JP2003500046A Expired - Lifetime JP4292471B2 (ja) 2001-05-30 2002-05-30 チオールアルキル安息香酸誘導体
JP2009011782A Pending JP2009149657A (ja) 2001-05-30 2009-01-22 チオールアルキル安息香酸誘導体

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US (2) US6740777B2 (enExample)
EP (2) EP1406867B1 (enExample)
JP (2) JP4292471B2 (enExample)
AT (1) ATE419232T1 (enExample)
AU (1) AU2002310202B2 (enExample)
CA (1) CA2448089C (enExample)
CY (1) CY1108893T1 (enExample)
DE (1) DE60230624D1 (enExample)
DK (1) DK1406867T3 (enExample)
ES (1) ES2319509T3 (enExample)
MX (1) MXPA03010859A (enExample)
PT (1) PT1406867E (enExample)
WO (1) WO2002096866A2 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009149657A (ja) * 2001-05-30 2009-07-09 Eisai Corp Of North America チオールアルキル安息香酸誘導体

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001092273A2 (en) * 2000-05-30 2001-12-06 Guilford Pharmaceuticals Inc. Benzenedicarboxylic acid derivatives
WO2003057670A2 (en) * 2001-12-28 2003-07-17 Guilford Pharmaceuticals Inc. Indoles as naaladase inhibitors
WO2004078180A2 (en) * 2003-03-03 2004-09-16 Guilford Pharmaceuticals Inc. Naaladase inhibitors for treating opioid tolerance
US7125907B2 (en) * 2003-03-03 2006-10-24 Guilford Pharmaceuticals Inc. Thiolactones
WO2004101483A1 (ja) * 2003-05-14 2004-11-25 Riken 新規３置換ベンゼン誘導体、その製造方法、およびそれを含む医薬組成物
US8198328B2 (en) 2004-01-21 2012-06-12 New York University Treatment of cancer using benzoic acid derivatives
US7282590B2 (en) * 2004-02-12 2007-10-16 The Research Foundation Of State University Of New York Drug conjugates
CA2726987C (en) * 2008-06-04 2014-02-18 Baylor College Of Medicine Stat3 inhibitors

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US3053890A (en) * 1960-03-31 1962-09-11 California Research Corp Reaction products of formaldehyde and o-mercaptomethylbenzoic acid
US4318846A (en) * 1979-09-07 1982-03-09 Syva Company Novel ether substituted fluorescein polyamino acid compounds as fluorescers and quenchers
US5089388A (en) 1983-04-19 1992-02-18 Syntex (U.S.A.) Inc. Antibodies for salicylate and their preparation
US5314918A (en) * 1987-06-24 1994-05-24 Smithkline Beecham Corporation Leukotriene antagonists
US5204358A (en) 1987-11-25 1993-04-20 Merck Frosst Canada, Inc. Hetaryl styryl quinolines as leukotriene inhibitors
US5258551A (en) 1991-12-18 1993-11-02 Shionogi & Co., Ltd. Process for producing α-ketoamide derivative
US5409780A (en) 1992-02-13 1995-04-25 Chemtrak, Inc. Aniline analogs for hydrogen peroxide detection
US5316887A (en) 1992-07-31 1994-05-31 Polaroid Corporation Thermally developable photosensitive material
US5453502A (en) 1994-03-16 1995-09-26 Eli Lilly And Company 1,3,4 substituted and bicyclic derivatives of 2-azetidinones and processes for preparation thereof
AR006793A1 (es) 1996-04-26 1999-09-29 Ishihara Sangyo Kaisha Compuestos pirazol o sus sales y herbicidas conteniendo los mismos
US6025344A (en) * 1996-06-17 2000-02-15 Guilford Pharmaceuticals Inc. Certain dioic acid derivatives useful as NAALADase inhibitors
IL120531A (en) 1997-03-26 2006-12-31 Yissum Res Dev Co Nitric oxide donors and pharmaceutical compositions containing them
US6265609B1 (en) 1998-07-06 2001-07-24 Guilford Pharmaceuticals Inc. Thio-substituted pentanedioic acid derivatives
EP1093453B1 (en) * 1998-07-06 2005-09-28 Guilford Pharmaceuticals Inc. Naaladase inhibitors useful as pharmaceutical compounds and compositions
US6479470B1 (en) * 1999-04-28 2002-11-12 Georgetown University Ligands for metabotropic glutamate receptors and inhibitors of NAALAdase
AU6661901A (en) * 2000-05-30 2001-12-11 Guilford Pharm Inc Naaladase inhibitors for treating retinal disorders and glaucoma
WO2001091738A2 (en) * 2000-05-30 2001-12-06 Guilford Pharmaceuticals Inc. Naaladase inhibitors for treating amyotrophic lateral sclerosis
WO2001092273A2 (en) * 2000-05-30 2001-12-06 Guilford Pharmaceuticals Inc. Benzenedicarboxylic acid derivatives
PT1406867E (pt) * 2001-05-30 2009-02-25 Eisai Corp North America Derivados do ácido tiolalquilbenzóico

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009149657A (ja) * 2001-05-30 2009-07-09 Eisai Corp Of North America チオールアルキル安息香酸誘導体

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Publication number Publication date
PT1406867E (pt) 2009-02-25
EP1406867A2 (en) 2004-04-14
US20040198824A1 (en) 2004-10-07
MXPA03010859A (es) 2004-02-17
AU2002310202B2 (en) 2008-05-15
EP2025666A2 (en) 2009-02-18
EP2025666A3 (en) 2010-03-31
WO2002096866A2 (en) 2002-12-05
WO2002096866A3 (en) 2004-01-15
ES2319509T3 (es) 2009-05-08
JP2009149657A (ja) 2009-07-09
DE60230624D1 (en) 2009-02-12
CY1108893T1 (el) 2014-07-02
EP1406867B1 (en) 2008-12-31
CA2448089A1 (en) 2002-12-05
JP2005503353A (ja) 2005-02-03
US7138543B2 (en) 2006-11-21
CA2448089C (en) 2010-10-19
ATE419232T1 (de) 2009-01-15
DK1406867T3 (da) 2009-04-06
US20030100607A1 (en) 2003-05-29
US6740777B2 (en) 2004-05-25

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