JP4282730B2 - Method for producing emulsified powder - Google Patents
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- JP4282730B2 JP4282730B2 JP2007117869A JP2007117869A JP4282730B2 JP 4282730 B2 JP4282730 B2 JP 4282730B2 JP 2007117869 A JP2007117869 A JP 2007117869A JP 2007117869 A JP2007117869 A JP 2007117869A JP 4282730 B2 JP4282730 B2 JP 4282730B2
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Description
本発明は油溶性物質の乳化粉末の製造方法に関する。本発明により得られる乳化粉末は打錠時の衝撃に対して油粒子を包むセルが破壊されにくく、油の滲みだし等がないので、錠剤化に適している。 The present invention relates to a method for producing an emulsified powder of an oil-soluble substance. The emulsified powder obtained according to the present invention is suitable for tableting because the cell surrounding the oil particles is not easily broken against the impact during tableting and the oil does not ooze out.
従来食用油脂類などの油溶性物質を含有する乳化粉末は、アラビアガムのような乳化剤、デキストリンのような賦形剤等を用いて油溶性物質を水に乳化分散させ、乳化液を噴霧乾燥、ドラム乾燥、ベルト乾燥、凍結乾燥など一般的な乾燥方法により乾燥することによって製造されている。また油溶性物質をグリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステルなどの合成界面活性剤を乳化剤として使用して、製造することも行われている。 Conventionally, an emulsified powder containing an oil-soluble substance such as edible oils and fats is obtained by emulsifying and dispersing an oil-soluble substance in water using an emulsifier such as gum arabic, an excipient such as dextrin, and the emulsion is spray-dried. It is manufactured by drying by a general drying method such as drum drying, belt drying, freeze drying and the like. In addition, oil-soluble substances are also produced using synthetic surfactants such as glycerin fatty acid esters, polyglycerin fatty acid esters, and sucrose fatty acid esters as emulsifiers.
アラビアガムを使用して製造された乳化粉末は、皮膜が強く比較的打錠に適しているものの、乳化粒子が微細化し難く、また油溶性物質の約２〜３倍量のアラビアガムが必要であるため油溶性物質の含有率に限界がある。 Although the emulsified powder produced using gum arabic has a strong film and is suitable for tableting, it is difficult to make the emulsified particles fine and about 2 to 3 times the amount of oil-soluble material is required. Therefore, the content of oil-soluble substances is limited.
合成界面活性剤は乳化性に優れているが、皮膜が弱く乾燥工程中に乳化セルが崩壊し、粉末表面に油の滲みだす割合が多く、油溶性物質の粉末化自体に適していない。 Synthetic surfactants are excellent in emulsifying properties, but the film is weak and the emulsifying cell collapses during the drying process, causing a large proportion of oil to ooze out on the powder surface, which is not suitable for pulverization of oil-soluble substances.
また乳化粉末化以外にゼラチンを使用したマイクロカプセル化による単核カプセルがあるが、ホルマリン処理等により表面を硬膜化させるため、皮膜部分の崩壊性が高く打錠時に崩壊するという欠点がある。 In addition to emulsification and powdering, there are mononuclear capsules by microencapsulation using gelatin. However, since the surface is hardened by a formalin treatment or the like, there is a drawback that the coating part is highly disintegratable and disintegrates during tableting.
このように従来技術により製造された油溶性物質の乳化粉末を使用して錠剤等を作る場合、油溶性物質の含有量の多い乳化粉末では打錠による油の滲みだしが多く起こるためその添加量が限定され、低い含有量の乳化粉末では乳化粉末を多量に使用することを要するが、錠剤構成上その添加量には限度があるので、結果として油溶性物質の含有量の高い錠剤が得られないというのが現状である。健康食品等として油溶性物質を錠剤形態で多量に摂取しようとする場合には、油溶性物質の含有量の高い錠剤が求められるので、打錠時に油の滲みだしのない油溶性物質乳化粉末の出現が強く期待されている。 Thus, when making tablets etc. using emulsified powders of oil-soluble substances produced by conventional techniques, the amount of oil added by emulsified powders with a high content of oil-soluble substances is often exuded by tableting. However, it is necessary to use a large amount of the emulsified powder in the case of the emulsified powder having a low content. However, the amount of the emulsified powder is limited due to the tablet structure, and as a result, a tablet having a high content of oil-soluble substances can be obtained. There is no current situation. When taking a large amount of oil-soluble substances in the form of tablets as health foods, etc., tablets with a high content of oil-soluble substances are required. Therefore, an oil-soluble substance emulsified powder that does not exude oil during tableting is required. The appearance is strongly expected.
本発明は、油溶性物質を含み、しかも衝撃に対して油粒子を含むセルが安定であり、打錠時に油の滲みだしのない乳化粉末を提供することを目的とする。 An object of the present invention is to provide an emulsified powder that contains an oil-soluble substance and that is stable in cells containing oil particles against impact and does not ooze oil during tableting.
本発明者等は上記課題の解決に向けて鋭意努力した結果、食用油脂類のような油溶性物質の芯物質を化工澱粉により乳化し、得られた乳化分散物を通常の手段を用いて乾燥することにより崩壊性の少ない乳化粉末が得られることを見いだし本発明を完成するに至った。そしてさらに、油溶性物質を乳化性に優れた化工澱粉と皮膜性に優れた植物ガムで被覆すると一層品質の優れた乳化粉末が得られることを見い出した。 As a result of diligent efforts to solve the above problems, the present inventors emulsified a core substance of an oil-soluble substance such as edible fats and oils with a modified starch, and dried the resulting emulsified dispersion using conventional means. As a result, it was found that an emulsified powder with less disintegration was obtained, and the present invention was completed. Furthermore, it has been found that when an oil-soluble substance is coated with a modified starch having an excellent emulsifying property and a plant gum having an excellent film property, an emulsified powder having further excellent quality can be obtained.
従って本発明は、油溶性物質および化工澱粉を水に加えて乳化し、乳化液を乾燥することを特徴とする乳化粉末の製造方法よりなる。 Accordingly, the present invention comprises a method for producing an emulsified powder characterized in that an oil-soluble substance and a modified starch are added to water to emulsify and the emulsion is dried.
さらに本発明は、油溶性物質、化工澱粉および植物ガムを水に加えて乳化し、乳化液を乾燥することを特徴とする乳化粉末の製造方法よりなる。 Furthermore, the present invention comprises a method for producing an emulsified powder, characterized in that an oil-soluble substance, a modified starch and a vegetable gum are added to water to emulsify and the emulsion is dried.
本発明によれば、打錠の衝撃による乳化の崩壊が少ない油溶性物質乳化粉末が得られる。油溶性物質乳化粉末を錠剤化したものは、取り扱い、計量、摂取などが容易であり、飲食品、医薬品等幅広い分野で利用される。 According to the present invention, an oil-soluble substance emulsified powder with little disruption of emulsification due to the impact of tableting can be obtained. Tablets of oil-soluble substance emulsified powder are easy to handle, measure, ingest, etc., and are used in a wide range of fields such as foods and drinks and pharmaceuticals.
本発明における乳化粉末は、芯物質である油溶性物質が化工澱粉等により被覆された粒子（セル）が多数凝集したものであり、その粒子径は５０〜５００ミクロンが適当である。乳化粉末が水に乳化したときの粒子径は２ミクロン以下が好ましい。 The emulsified powder in the present invention is a product in which a large number of particles (cells) in which an oil-soluble substance, which is a core substance, is coated with a modified starch or the like is aggregated, and the particle diameter is suitably 50 to 500 microns. The particle size when the emulsified powder is emulsified in water is preferably 2 microns or less.
本発明における油溶性物質としては、ビタミンＡ、ビタミンＥ、ビタミンＡアセテート、ビタミンＥアセテート等の油溶性ビタミン類、ＤＨＡ（ドコサヘキサエン酸）、ＥＰＡ（エイコサペンタエン酸）等の高級不飽和脂肪酸類、オレンジ油、レモン油、ペパーミント油のような油溶性香味料等を使用することができる。 Examples of the oil-soluble substance in the present invention include oil-soluble vitamins such as vitamin A, vitamin E, vitamin A acetate, and vitamin E acetate, higher unsaturated fatty acids such as DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid), orange Oil-soluble flavors such as oil, lemon oil, and peppermint oil can be used.
本発明で使用される化工澱粉とは、米国官報ＣＦＲ（FDA）172.89 (d), 1995 に“Food starch-modified”として記載されている、澱粉と有機酸とのエステルであって乳化作用を有するものをいう。上記有機酸の例としてはコハク酸、酢酸、アジピン酸またはこれらのアルキルもしくはアルケニル誘導体、例えばオクテニルコハク酸があげられる。化工澱粉としては、澱粉とオクテニルコハク酸との半エステル（米国特許第3,971,852参照）であるオクテニルコハク酸澱粉またはその塩が特に好ましく、その例としてエマルスター３０Ａ（松谷化学株式会社製の商品名)、カプシュール（ナショナルスターチ社の商品名）などが挙げられる。 The modified starch used in the present invention is an ester of starch and an organic acid, which is described as “Food starch-modified” in the US Gazette CFR (FDA) 172.89 (d), 1995, and has an emulsifying action. Say things. Examples of the organic acid include succinic acid, acetic acid, adipic acid or alkyl or alkenyl derivatives thereof such as octenyl succinic acid. As the modified starch, octenyl succinic acid starch or a salt thereof, which is a half ester of starch and octenyl succinic acid (see US Pat. No. 3,971,852), and its salt are particularly preferable. (National Starch's trade name).
本発明における植物ガムとしては、アラビアガム、キサンタンガム、グアガム等のほか、プルラン、ペクチンも使用することができる。 In addition to gum arabic, xanthan gum, guar gum and the like, pullulan and pectin can also be used as the plant gum in the present invention.
本発明の方法を実施するに際しては、先ず、水１５０〜２００部（重量部、以下同じ）、化工澱粉１〜９０部、所望によりさらに植物ガム１〜５０部の混合物に油溶性物質１０〜６０部を加え、温度１０〜６０℃、ホモミキサー回転数5000〜15000回／分で５〜２０分間攪拌することにより油溶性物質の乳化液を調製する。打錠時に於ける崩壊性を少なくするためには、好ましくは、２ミクロン以下の乳化粒子径とするのが望ましい。このとき使用する乳化機はより強い剪断力をもつ高速攪拌乳化機例えばクレアミックス（エムテクニック社製の商品名）かホモゲナイザーなどの高圧乳化機が適切であるが、これらの装置に限定されるものではない。かくして得られた乳化液をそのまま噴霧乾燥、ドラム乾燥、ベルト乾燥、凍結乾燥など適当な手段で乾燥することにより打錠性能に優れた乳化粉末を得ることができる。本発明の方法により得られた乳化粉末は、水分散性もよく又流動性にも優れている。 In carrying out the method of the present invention, first, oil-soluble substances 10-60 in a mixture of water 150-200 parts (parts by weight, the same shall apply hereinafter), modified starch 1-90 parts, optionally further plant gum 1-50 parts. An emulsion of an oil-soluble substance is prepared by stirring for 5 to 20 minutes at a temperature of 10 to 60 ° C. and a homomixer rotation speed of 5000 to 15000 times / minute. In order to reduce disintegration during tableting, it is desirable that the emulsified particle diameter is preferably 2 microns or less. As the emulsifier used at this time, a high-speed agitating emulsifier having a stronger shearing force, for example, CLEAMIX (trade name manufactured by M Technique Co., Ltd.) or a high-pressure emulsifier such as a homogenizer is suitable, but is limited to these devices. is not. The emulsion thus obtained can be directly dried by a suitable means such as spray drying, drum drying, belt drying or freeze drying to obtain an emulsified powder excellent in tableting performance. The emulsified powder obtained by the method of the present invention has good water dispersibility and fluidity.
以下実施例により本発明をさらに具体的に説明する。
〔実施例１〕
水１５０ｇに化工澱粉（松谷化学株式会社製；商品名「エマルスター３０Ａ」）２０ｇ、乳糖３０ｇ及びアラビアガム２０ｇを加えて溶解し、８５〜９０℃で１５分加熱殺菌する。これを４０℃以下に冷却し、ビタミンＥ３０ｇを添加し、混合した後ＴＫ−ホモミキサー（特殊機化工業製）で乳化した。乳化粒子をより微細化するためクレアミックス（エムテクニック社製乳化機の商品名）で再乳化を行った。この乳液を噴霧乾燥機（大川原化工機製）を使用して、入口温度１４０℃、排風温度９０℃にて噴霧乾燥し、ビタミンＥ乳化粉末（本発明品１）９０ｇを得た。
Hereinafter, the present invention will be described more specifically with reference to examples.
[Example 1]
To 150 g of water, 20 g of modified starch (manufactured by Matsutani Chemical Co., Ltd .; trade name “Emulstar 30A”), 30 g of lactose and 20 g of gum arabic are added and dissolved, and sterilized by heating at 85 to 90 ° C. for 15 minutes. This was cooled to 40 ° C. or less, 30 g of vitamin E was added and mixed, and then emulsified with a TK-homomixer (manufactured by Tokushu Kika Kogyo). In order to make the emulsified particles finer, re-emulsification was performed with CLEARMIX (trade name of an emulsifier manufactured by MTechnic Co., Ltd.). This emulsion was spray-dried at an inlet temperature of 140 ° C. and an exhaust air temperature of 90 ° C. using a spray dryer (manufactured by Okawahara Kako) to obtain 90 g of vitamin E emulsified powder (Product 1 of the present invention).
〔実施例２〕
脱気水１５０ｇに化工澱粉（ナショナルスターチ社製；商品名「カプシュール」）３０ｇ、乳糖１４ｇ、アラビアガム２５ｇを加えて溶解し、８５〜９０℃で１５分加熱殺菌する。これを４０℃以下に冷却し、ＤＨＡオイル３０ｇ、ビタミンＥ１ｇを添加混合した後ＴＫ−ホモミキサーで乳化した。乳化粒子をより微細化するためクレアミックス（エムテクニック社製乳化機の商品名）で再乳化を行った。この溶液を噴霧乾燥機（大川原化工機製）を使用して、入口温度１４０℃、排風温度９０℃にて噴霧乾燥し、ＤＨＡ乳化粉末（本発明品２）９０ｇを得た。
[Example 2]
To 150 g of deaerated water, 30 g of modified starch (manufactured by National Starch; trade name “Capsule”), 14 g of lactose and 25 g of gum arabic are added and dissolved, and sterilized by heating at 85 to 90 ° C. for 15 minutes. This was cooled to 40 ° C. or lower, 30 g of DHA oil and 1 g of vitamin E were added and mixed, and then emulsified with a TK-homomixer. In order to make the emulsified particles finer, re-emulsification was performed with CLEARMIX (trade name of an emulsifier manufactured by MTechnic Co., Ltd.). This solution was spray-dried at an inlet temperature of 140 ° C. and an exhaust air temperature of 90 ° C. using a spray dryer (manufactured by Okawahara Kako) to obtain 90 g of DHA emulsified powder (Product 2 of the present invention).
〔実施例３〕
実施例２のＤＨＡオイル３０ｇの代わりにペパーミント油３０ｇを使用する以外は実施例２と同様の操作を行いペパーミント油乳化粉末９０ｇを得た。
Example 3
90 g of peppermint oil emulsified powder was obtained by performing the same operation as in Example 2 except that 30 g of peppermint oil was used instead of 30 g of DHA oil of Example 2.
〔実施例４〕
水１５０ｇに実施例１で使用した化工澱粉２０ｇ及びデキストリン（ＤＥ１０）５０ｇを加えて溶解殺菌した後、ビタミンＥ３０ｇを添加し、実施例１と同様の操作を行いビタミンＥ乳化粉末（本発明品４）９０ｇを得た。
Example 4
After adding 20 g of the modified starch and 50 g of dextrin (DE10) used in Example 1 to 150 g of water and dissolving and sterilizing it, 30 g of vitamin E was added, and the same operation as in Example 1 was performed to prepare a vitamin E emulsified powder (Product 4 of the present invention). ) 90 g was obtained.
〔実施例５〕
脱気水１５０ｇに実施例２で使用した化工澱粉３０ｇ及びデキストリン(ＤＥ１０）３９ｇを加えて溶解殺菌した後、ＤＨＡオイル３０ｇ、ビタミンＥ１ｇを添加し、実施例１と同様の操作を行いＤＨＡ乳化粉末（本発明品５）９０ｇを得た。
Example 5
30 g of modified starch and 39 g of dextrin (DE10) used in Example 2 were added to 150 g of degassed water and dissolved and sterilized. Then, 30 g of DHA oil and 1 g of vitamin E were added, and the same operation as in Example 1 was performed. (Invention product 5) 90 g was obtained.
〔実施例６〕
化工澱粉（松谷化学(株)製；エマルスター３０Ａ）５kgを精製水１５kgに溶解した。これにビタミンＥアセテート（エーザイ(株)製）５kgを添加しＴＫ−ホモミキサーと加圧乳化機により乳化した。この乳化液をスプレードライヤー（大川原化工機製）により入口温度１６０℃、排風温度８０℃で噴霧乾燥し、ビタミンＥ粉末を得た。このビタミンＥ粉末９９０ｇに流動化剤として含水二酸化ケイ素（富士シリシア製；サイリシア３５５）を１０ｇ加え混合しビタミンＥ粉末（本発明品６）を得た。
Example 6
5 kg of modified starch (Matsutani Chemical Co., Ltd .; Emulster 30A) was dissolved in 15 kg of purified water. To this was added 5 kg of vitamin E acetate (manufactured by Eisai Co., Ltd.), and the mixture was emulsified with a TK-homomixer and a pressure emulsifier. This emulsion was spray-dried with a spray dryer (manufactured by Okawara Chemical Co., Ltd.) at an inlet temperature of 160 ° C. and an exhaust air temperature of 80 ° C. to obtain vitamin E powder. To 990 g of this vitamin E powder, 10 g of hydrous silicon dioxide (manufactured by Fuji Silysia; Silysia 355) was added and mixed as a fluidizing agent to obtain vitamin E powder (product 6 of the present invention).
〔参考例１〕
実施例４の化工澱粉の代わりにアラビアガムを同量使用する以外は、実施例４と同様の操作を行いビタミンＥ乳化粉末（参考品１）９０ｇを得た。
[Reference Example 1]
90 g of vitamin E emulsified powder (Reference product 1) was obtained by performing the same operation as in Example 4 except that the same amount of gum arabic was used in place of the modified starch of Example 4.
〔参考例２〕
実施例５の化工澱粉の代わりにアラビアガムを同量使用する以外は、実施例５と同様の操作を行いＤＨＡ乳化粉末（参考品２）９０ｇを得た。
[Reference Example 2]
The same operation as in Example 5 was performed except that the same amount of gum arabic was used in place of the modified starch of Example 5, to obtain 90 g of DHA emulsified powder (Reference product 2).
〔比較例１〕
下記に示す処方物を常法により打錠して錠剤を作成した。作成した錠剤をポリ袋にいれ４０℃にて１週間保存した。
[Comparative Example 1]
The formulation shown below was tableted by a conventional method to prepare tablets. The prepared tablets were placed in a plastic bag and stored at 40 ° C. for 1 week.
上述の錠剤の表面を顕微鏡観察するとともに、錠剤１個（1.5ｇ）を３０ｇの水に溶解させた後、乳化粒子の顕微鏡観察を行った。その結果、本発明品１及び２を配合したNO.１及びNO.２は、錠剤表面にオイルの滲みだしは認められず、また顕微鏡観察でも水に分散後の乳化粒子は最大３ミクロン程度で、打錠による乳化粒子の崩壊は観察されなかった。本発明品４または５を配合したNO.３またはNO.５は、錠剤表面にオイルの滲みだしがわずかに観察され、乳化粒子の崩壊も一部みられたが、実用に十分耐えるものであった。一方参考品１または２を配合したNO.４またはNO.６は、錠剤表面に一部オイルの滲みだしが認められ、水に分散後の顕微鏡観察でも合一した乳化粒子が観察された。また上述の錠剤を４０℃にて１週間保管した後、専門パネラー１０名にて香味の官能評価を行った。その結果、本発明品１及び２を配合したNO.１及びNO.２は、保存に於ける劣化臭が認められないと判定した。一方参考品１または参考品２を配合したNO.４またはNO.６は、専門パネラー全員が保存に於ける著しい劣化臭が認められると判定した。打錠前の配合物を上記と同じ方法で評価したところ、NO.１〜NO.６に於ける有意差は認められなかった。上記の結果から保存に於ける劣化臭は、打錠時の乳化粒子の崩壊が原因とみられる。 While the surface of the above-mentioned tablet was observed with a microscope, one tablet (1.5 g) was dissolved in 30 g of water, and then the emulsion particles were observed with a microscope. As a result, NO.1 and NO.2 blended with the products 1 and 2 of the present invention showed no oil oozing on the tablet surface, and the emulsion particles after dispersion in water had a maximum size of about 3 microns even under microscopic observation. No disintegration of the emulsified particles due to tableting was observed. No. 3 or NO. 5 containing the product 4 or 5 of the present invention showed a slight oil oozing on the tablet surface and some disintegration of the emulsified particles. It was. On the other hand, in the case of NO.4 or NO.6 blended with the reference product 1 or 2, part of the oil was oozed out on the tablet surface, and the emulsified particles were also observed by microscopic observation after dispersion in water. Moreover, after storing the above-mentioned tablet at 40 ° C. for 1 week, sensory evaluation of flavor was performed by 10 professional panelists. As a result, it was determined that NO.1 and NO.2 containing the products 1 and 2 of the present invention did not show a deterioration odor during storage. On the other hand, NO.4 or NO.6 in which Reference product 1 or Reference product 2 was blended was judged by all the specialized panelists to have a noticeable odor during storage. When the composition before tableting was evaluated by the same method as described above, no significant difference was found in NO.1 to NO.6. From the above results, the deterioration odor during storage seems to be caused by the collapse of the emulsified particles during tableting.
このことから、化工澱粉及び植物ガムにて被覆した粉末は、打錠時に崩壊が少なく打錠性に優れた効果を発揮し、極めて有用であることがわかる。 From this, it can be seen that the powder coated with the modified starch and the plant gum is very useful because it exhibits an excellent tableting property with little disintegration during tableting.
Claims (11)
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| JP2007117869A JP4282730B2 (en) | 1997-10-07 | 2007-04-27 | Method for producing emulsified powder |
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| KR101805200B1 (en) * | 2009-02-11 | 2017-12-05 | 디에스엠 아이피 어셋츠 비.브이. | High concentrated pufa emulsions |
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